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Protein

Nuclear transcription factor Y subunit gamma

Gene

NFYC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-380994 ATF4 activates genes
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
SIGNORiQ13952

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transcription factor Y subunit gamma
Alternative name(s):
CAAT box DNA-binding protein subunit C
Nuclear transcription factor Y subunit C
Short name:
NF-YC
Transactivator HSM-1/2
Gene namesi
Name:NFYC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000066136.19
HGNCiHGNC:7806 NFYC
MIMi605344 gene
neXtProtiNX_Q13952

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4802
OpenTargetsiENSG00000066136
PharmGKBiPA31611

Polymorphism and mutation databases

BioMutaiNFYC
DMDMi20137773

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182461 – 458Nuclear transcription factor Y subunit gammaAdd BLAST458

Proteomic databases

EPDiQ13952
MaxQBiQ13952
PaxDbiQ13952
PeptideAtlasiQ13952
PRIDEiQ13952
ProteomicsDBi59772
59773 [Q13952-2]
59774 [Q13952-3]
59775 [Q13952-4]
59776 [Q13952-5]
59777 [Q13952-6]

PTM databases

iPTMnetiQ13952
PhosphoSitePlusiQ13952

Expressioni

Gene expression databases

BgeeiENSG00000066136 Expressed in 236 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiQ13952 baseline and differential
GenevisibleiQ13952 HS

Organism-specific databases

HPAiHPA055011

Interactioni

Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110868, 70 interactors
ComplexPortaliCPX-1956 CCAAT-binding factor complex
CORUMiQ13952
IntActiQ13952, 58 interactors
MINTiQ13952
STRINGi9606.ENSP00000396620

Structurei

Secondary structure

1458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13952
SMRiQ13952
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13952

Family & Domainsi

Sequence similaritiesi

Belongs to the NFYC/HAP5 subunit family.Curated

Phylogenomic databases

eggNOGiKOG1657 Eukaryota
COG5208 LUCA
GeneTreeiENSGT00530000063560
HOGENOMiHOG000231074
HOVERGENiHBG002885
InParanoidiQ13952
KOiK08066
OrthoDBiEOG091G0HN1
PhylomeDBiQ13952
TreeFamiTF354207

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
IPR027170 NFYC/HAP5_su
PANTHERiPTHR10252:SF8 PTHR10252:SF8, 1 hit
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q13952-1) [UniParc]FASTAAdd to basket
Also known as: DS2.8

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK
60 70 80 90 100
IMKLDEDVKM ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND
110 120 130 140 150
IAMAITKFDQ FDFLIDIVPR DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ
160 170 180 190 200
QPTAVQVQGQ QQGQQTTSST TTIQPGQIII AQPQQGQTTP VTMQVGEGQQ
210 220 230 240 250
VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP VQLNAGQLQY
260 270 280 290 300
IRLAQPVSGT QVVQGQIQTL ATNAQQGQRN ASQGKPRRCL KETLQITQTE
310 320 330 340 350
VQQGQQQFSQ FTDGQRNSVQ QARVSELTGE AEPREVKATG NSTPCTSSLP
360 370 380 390 400
TTHPPSHRAG ASCVCCSQPQ QSSTSPPPSD ALQWVVVEVS GTPNQLETHR
410 420 430 440 450
ELHAPLPGMT SLSPLHPSQQ LYQIQQVTMP AGQDLAQPMF IQSANQPSDG

QAPQVTGD
Length:458
Mass (Da):50,302
Last modified:January 23, 2002 - v3
Checksum:iB17B2C7F622653B9
GO
Isoform 1 (identifier: Q13952-2) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.
     316-419: Missing.

Show »
Length:335
Mass (Da):37,194
Checksum:iD83635C1773C3895
GO
Isoform 2 (identifier: Q13952-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.

Show »
Length:439
Mass (Da):48,150
Checksum:iE3FED3512983A402
GO
Isoform 4 (identifier: Q13952-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-97: Missing.
     277-295: Missing.
     316-419: Missing.

Note: No experimental confirmation available.
Show »
Length:297
Mass (Da):32,828
Checksum:i6E5693FBF9D838ED
GO
Isoform 5 (identifier: Q13952-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-419: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):39,346
Checksum:i80887376BB8125F3
GO
Isoform 6 (identifier: Q13952-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-219: Missing.
     277-295: Missing.
     316-419: Missing.

Note: No experimental confirmation available.
Show »
Length:301
Mass (Da):33,702
Checksum:i1BC4774E7E20894A
GO
Isoform 7 (identifier: Q13952-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.
     315-315: Missing.
     316-419: Missing.

Note: No experimental confirmation available.
Show »
Length:334
Mass (Da):37,066
Checksum:i685A01326BF0FFB1
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T6K5Q5T6K5_HUMAN
Nuclear transcription factor Y subu...
NFYC
313Annotation score:
Q5T6K7Q5T6K7_HUMAN
Nuclear transcription factor Y subu...
NFYC
129Annotation score:
E9PQR2E9PQR2_HUMAN
Nuclear transcription factor Y subu...
NFYC
60Annotation score:
E9PI99E9PI99_HUMAN
Nuclear transcription factor Y subu...
NFYC
141Annotation score:
E9PL11E9PL11_HUMAN
Nuclear transcription factor Y subu...
NFYC
95Annotation score:
E9PJA8E9PJA8_HUMAN
Nuclear transcription factor Y subu...
NFYC
52Annotation score:
A0A0A0MT00A0A0A0MT00_HUMAN
Nuclear transcription factor Y subu...
NFYC
179Annotation score:
H0Y803H0Y803_HUMAN
Nuclear transcription factor Y subu...
NFYC
186Annotation score:

Sequence cautioni

The sequence BAD92212 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52M → I in CAA99055 (PubMed:9332362).Curated1
Sequence conflicti90D → N in BAA14051 (PubMed:10446203).Curated1
Sequence conflicti155V → L in AAC50816 (PubMed:8910521).Curated1
Sequence conflicti158Q → H in BAA14051 (PubMed:10446203).Curated1
Sequence conflicti171T → N in BAA14051 (PubMed:10446203).Curated1
Sequence conflicti175P → A in AAC50816 (PubMed:8910521).Curated1
Sequence conflicti179I → F in BAA14051 (PubMed:10446203).Curated1
Sequence conflicti198G → S in BAA12818 (PubMed:10446203).Curated1
Sequence conflicti198G → S in BAA14051 (PubMed:10446203).Curated1
Sequence conflicti202Q → K in BAA12818 (PubMed:10446203).Curated1
Sequence conflicti216 – 217QS → HN in BAA14051 (PubMed:10446203).Curated2
Sequence conflicti248L → V in AAC50816 (PubMed:8910521).Curated1
Sequence conflicti271A → V in AAC50816 (PubMed:8910521).Curated1
Sequence conflicti451Q → K in BAA14051 (PubMed:10446203).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035702165Q → H in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04334860 – 97Missing in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_043349186 – 219Missing in isoform 6. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_000851277 – 295Missing in isoform 1, isoform 2, isoform 4, isoform 6 and isoform 7. 8 PublicationsAdd BLAST19
Alternative sequenceiVSP_046350315Missing in isoform 7. 1 Publication1
Alternative sequenceiVSP_000852316 – 419Missing in isoform 1, isoform 4, isoform 5, isoform 6 and isoform 7. 8 PublicationsAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62296 mRNA Translation: AAC50816.1
U78774 mRNA Translation: AAC51669.1
Z74792 mRNA Translation: CAA99055.1
D85425 mRNA Translation: BAA12818.1
D89986 mRNA Translation: BAA14051.1
AF191744 mRNA Translation: AAG28389.1
AK000346 mRNA Translation: BAA91100.1
AK127677 mRNA Translation: BAG54549.1
AK300774 mRNA Translation: BAG62438.1
AK301385 mRNA Translation: BAG62925.1
BT020081 mRNA Translation: AAV38884.1
AB208975 mRNA Translation: BAD92212.1 Different initiation.
AL031289 Genomic DNA No translation available.
AC119677 Genomic DNA No translation available.
AL354914 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07198.1
CH471059 Genomic DNA Translation: EAX07201.1
CH471059 Genomic DNA Translation: EAX07202.1
CH471059 Genomic DNA Translation: EAX07203.1
BC005003 mRNA Translation: AAH05003.1
CCDSiCCDS44120.1 [Q13952-5]
CCDS44121.1 [Q13952-7]
CCDS44122.1 [Q13952-6]
CCDS44123.1 [Q13952-4]
CCDS455.1 [Q13952-2]
CCDS81305.1 [Q13952-1]
CCDS81306.1 [Q13952-3]
RefSeqiNP_001136059.1, NM_001142587.1 [Q13952-7]
NP_001136060.1, NM_001142588.1 [Q13952-5]
NP_001136061.1, NM_001142589.1 [Q13952-4]
NP_001136062.1, NM_001142590.1 [Q13952-6]
NP_001295043.1, NM_001308114.1 [Q13952-1]
NP_001295044.1, NM_001308115.1 [Q13952-3]
NP_055038.2, NM_014223.4 [Q13952-2]
XP_005270951.1, XM_005270894.1 [Q13952-1]
XP_005270952.3, XM_005270895.3
XP_006710721.2, XM_006710658.2 [Q13952-3]
XP_006710723.2, XM_006710660.2 [Q13952-5]
XP_006710724.1, XM_006710661.1 [Q13952-3]
XP_006710725.2, XM_006710662.2
XP_011539818.1, XM_011541516.1 [Q13952-1]
XP_016856854.1, XM_017001365.1 [Q13952-1]
XP_016856856.1, XM_017001367.1 [Q13952-5]
XP_016856857.1, XM_017001368.1 [Q13952-2]
XP_016856858.1, XM_017001369.1 [Q13952-2]
UniGeneiHs.713051

Genome annotation databases

EnsembliENST00000308733; ENSP00000312617; ENSG00000066136 [Q13952-1]
ENST00000372651; ENSP00000361734; ENSG00000066136 [Q13952-2]
ENST00000372652; ENSP00000361736; ENSG00000066136 [Q13952-3]
ENST00000372653; ENSP00000361737; ENSG00000066136 [Q13952-6]
ENST00000372654; ENSP00000361738; ENSG00000066136 [Q13952-2]
ENST00000425457; ENSP00000396620; ENSG00000066136 [Q13952-5]
ENST00000427410; ENSP00000408315; ENSG00000066136 [Q13952-4]
ENST00000440226; ENSP00000414299; ENSG00000066136 [Q13952-2]
ENST00000447388; ENSP00000404427; ENSG00000066136 [Q13952-2]
ENST00000456393; ENSP00000408867; ENSG00000066136 [Q13952-7]
GeneIDi4802
KEGGihsa:4802
UCSCiuc001cfx.6 human [Q13952-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62296 mRNA Translation: AAC50816.1
U78774 mRNA Translation: AAC51669.1
Z74792 mRNA Translation: CAA99055.1
D85425 mRNA Translation: BAA12818.1
D89986 mRNA Translation: BAA14051.1
AF191744 mRNA Translation: AAG28389.1
AK000346 mRNA Translation: BAA91100.1
AK127677 mRNA Translation: BAG54549.1
AK300774 mRNA Translation: BAG62438.1
AK301385 mRNA Translation: BAG62925.1
BT020081 mRNA Translation: AAV38884.1
AB208975 mRNA Translation: BAD92212.1 Different initiation.
AL031289 Genomic DNA No translation available.
AC119677 Genomic DNA No translation available.
AL354914 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07198.1
CH471059 Genomic DNA Translation: EAX07201.1
CH471059 Genomic DNA Translation: EAX07202.1
CH471059 Genomic DNA Translation: EAX07203.1
BC005003 mRNA Translation: AAH05003.1
CCDSiCCDS44120.1 [Q13952-5]
CCDS44121.1 [Q13952-7]
CCDS44122.1 [Q13952-6]
CCDS44123.1 [Q13952-4]
CCDS455.1 [Q13952-2]
CCDS81305.1 [Q13952-1]
CCDS81306.1 [Q13952-3]
RefSeqiNP_001136059.1, NM_001142587.1 [Q13952-7]
NP_001136060.1, NM_001142588.1 [Q13952-5]
NP_001136061.1, NM_001142589.1 [Q13952-4]
NP_001136062.1, NM_001142590.1 [Q13952-6]
NP_001295043.1, NM_001308114.1 [Q13952-1]
NP_001295044.1, NM_001308115.1 [Q13952-3]
NP_055038.2, NM_014223.4 [Q13952-2]
XP_005270951.1, XM_005270894.1 [Q13952-1]
XP_005270952.3, XM_005270895.3
XP_006710721.2, XM_006710658.2 [Q13952-3]
XP_006710723.2, XM_006710660.2 [Q13952-5]
XP_006710724.1, XM_006710661.1 [Q13952-3]
XP_006710725.2, XM_006710662.2
XP_011539818.1, XM_011541516.1 [Q13952-1]
XP_016856854.1, XM_017001365.1 [Q13952-1]
XP_016856856.1, XM_017001367.1 [Q13952-5]
XP_016856857.1, XM_017001368.1 [Q13952-2]
XP_016856858.1, XM_017001369.1 [Q13952-2]
UniGeneiHs.713051

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N1JX-ray1.67B27-120[»]
4AWLX-ray3.08C27-120[»]
4CSRX-ray1.50B27-120[»]
ProteinModelPortaliQ13952
SMRiQ13952
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110868, 70 interactors
ComplexPortaliCPX-1956 CCAAT-binding factor complex
CORUMiQ13952
IntActiQ13952, 58 interactors
MINTiQ13952
STRINGi9606.ENSP00000396620

PTM databases

iPTMnetiQ13952
PhosphoSitePlusiQ13952

Polymorphism and mutation databases

BioMutaiNFYC
DMDMi20137773

Proteomic databases

EPDiQ13952
MaxQBiQ13952
PaxDbiQ13952
PeptideAtlasiQ13952
PRIDEiQ13952
ProteomicsDBi59772
59773 [Q13952-2]
59774 [Q13952-3]
59775 [Q13952-4]
59776 [Q13952-5]
59777 [Q13952-6]

Protocols and materials databases

DNASUi4802
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308733; ENSP00000312617; ENSG00000066136 [Q13952-1]
ENST00000372651; ENSP00000361734; ENSG00000066136 [Q13952-2]
ENST00000372652; ENSP00000361736; ENSG00000066136 [Q13952-3]
ENST00000372653; ENSP00000361737; ENSG00000066136 [Q13952-6]
ENST00000372654; ENSP00000361738; ENSG00000066136 [Q13952-2]
ENST00000425457; ENSP00000396620; ENSG00000066136 [Q13952-5]
ENST00000427410; ENSP00000408315; ENSG00000066136 [Q13952-4]
ENST00000440226; ENSP00000414299; ENSG00000066136 [Q13952-2]
ENST00000447388; ENSP00000404427; ENSG00000066136 [Q13952-2]
ENST00000456393; ENSP00000408867; ENSG00000066136 [Q13952-7]
GeneIDi4802
KEGGihsa:4802
UCSCiuc001cfx.6 human [Q13952-1]

Organism-specific databases

CTDi4802
DisGeNETi4802
EuPathDBiHostDB:ENSG00000066136.19
GeneCardsiNFYC
HGNCiHGNC:7806 NFYC
HPAiHPA055011
MIMi605344 gene
neXtProtiNX_Q13952
OpenTargetsiENSG00000066136
PharmGKBiPA31611
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1657 Eukaryota
COG5208 LUCA
GeneTreeiENSGT00530000063560
HOGENOMiHOG000231074
HOVERGENiHBG002885
InParanoidiQ13952
KOiK08066
OrthoDBiEOG091G0HN1
PhylomeDBiQ13952
TreeFamiTF354207

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-380994 ATF4 activates genes
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
SIGNORiQ13952

Miscellaneous databases

ChiTaRSiNFYC human
EvolutionaryTraceiQ13952
GeneWikiiNFYC
GenomeRNAii4802
PROiPR:Q13952
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000066136 Expressed in 236 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiQ13952 baseline and differential
GenevisibleiQ13952 HS

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
IPR027170 NFYC/HAP5_su
PANTHERiPTHR10252:SF8 PTHR10252:SF8, 1 hit
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNFYC_HUMAN
AccessioniPrimary (citable) accession number: Q13952
Secondary accession number(s): B4DUS6
, B4DW63, D3DPV9, F8VWM3, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: November 7, 2018
This is version 191 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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