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Entry version 194 (13 Feb 2019)
Sequence version 3 (23 Jan 2002)
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Protein

Nuclear transcription factor Y subunit gamma

Gene

NFYC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-380994 ATF4 activates genes
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
R-HSA-9614657 FOXO-mediated transcription of cell death genes

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13952

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear transcription factor Y subunit gamma
Alternative name(s):
CAAT box DNA-binding protein subunit C
Nuclear transcription factor Y subunit C
Short name:
NF-YC
Transactivator HSM-1/2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFYC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000066136.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7806 NFYC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605344 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13952

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4802

Open Targets

More...
OpenTargetsi
ENSG00000066136

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31611

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NFYC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20137773

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002182461 – 458Nuclear transcription factor Y subunit gammaAdd BLAST458

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13952

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13952

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13952

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13952

PeptideAtlas

More...
PeptideAtlasi
Q13952

PRoteomics IDEntifications database

More...
PRIDEi
Q13952

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59772
59773 [Q13952-2]
59774 [Q13952-3]
59775 [Q13952-4]
59776 [Q13952-5]
59777 [Q13952-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13952

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13952

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000066136 Expressed in 236 organ(s), highest expression level in epithelium of mammary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13952 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13952 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055011

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110868, 70 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1956 CCAAT-binding factor complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q13952

Protein interaction database and analysis system

More...
IntActi
Q13952, 58 interactors

Molecular INTeraction database

More...
MINTi
Q13952

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000396620

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N1JX-ray1.67B27-120[»]
4AWLX-ray3.08C27-120[»]
4CSRX-ray1.50B27-120[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q13952

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13952

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13952

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NFYC/HAP5 subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1657 Eukaryota
COG5208 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155689

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231074

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002885

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13952

KEGG Orthology (KO)

More...
KOi
K08066

Database of Orthologous Groups

More...
OrthoDBi
1558176at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13952

TreeFam database of animal gene trees

More...
TreeFami
TF354207

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
IPR027170 NFYC/HAP5_su

The PANTHER Classification System

More...
PANTHERi
PTHR10252:SF8 PTHR10252:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113 SSF47113, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q13952-1) [UniParc]FASTAAdd to basket
Also known as: DS2.8

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK
60 70 80 90 100
IMKLDEDVKM ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND
110 120 130 140 150
IAMAITKFDQ FDFLIDIVPR DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ
160 170 180 190 200
QPTAVQVQGQ QQGQQTTSST TTIQPGQIII AQPQQGQTTP VTMQVGEGQQ
210 220 230 240 250
VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP VQLNAGQLQY
260 270 280 290 300
IRLAQPVSGT QVVQGQIQTL ATNAQQGQRN ASQGKPRRCL KETLQITQTE
310 320 330 340 350
VQQGQQQFSQ FTDGQRNSVQ QARVSELTGE AEPREVKATG NSTPCTSSLP
360 370 380 390 400
TTHPPSHRAG ASCVCCSQPQ QSSTSPPPSD ALQWVVVEVS GTPNQLETHR
410 420 430 440 450
ELHAPLPGMT SLSPLHPSQQ LYQIQQVTMP AGQDLAQPMF IQSANQPSDG

QAPQVTGD
Length:458
Mass (Da):50,302
Last modified:January 23, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB17B2C7F622653B9
GO
Isoform 1 (identifier: Q13952-2) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.
     316-419: Missing.

Show »
Length:335
Mass (Da):37,194
Checksum:iD83635C1773C3895
GO
Isoform 2 (identifier: Q13952-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.

Show »
Length:439
Mass (Da):48,150
Checksum:iE3FED3512983A402
GO
Isoform 4 (identifier: Q13952-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-97: Missing.
     277-295: Missing.
     316-419: Missing.

Note: No experimental confirmation available.
Show »
Length:297
Mass (Da):32,828
Checksum:i6E5693FBF9D838ED
GO
Isoform 5 (identifier: Q13952-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-419: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):39,346
Checksum:i80887376BB8125F3
GO
Isoform 6 (identifier: Q13952-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-219: Missing.
     277-295: Missing.
     316-419: Missing.

Note: No experimental confirmation available.
Show »
Length:301
Mass (Da):33,702
Checksum:i1BC4774E7E20894A
GO
Isoform 7 (identifier: Q13952-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.
     315-315: Missing.
     316-419: Missing.

Note: No experimental confirmation available.
Show »
Length:334
Mass (Da):37,066
Checksum:i685A01326BF0FFB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T6K5Q5T6K5_HUMAN
Nuclear transcription factor Y subu...
NFYC
313Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T6K7Q5T6K7_HUMAN
Nuclear transcription factor Y subu...
NFYC
129Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQR2E9PQR2_HUMAN
Nuclear transcription factor Y subu...
NFYC
60Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI99E9PI99_HUMAN
Nuclear transcription factor Y subu...
NFYC
141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL11E9PL11_HUMAN
Nuclear transcription factor Y subu...
NFYC
95Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJA8E9PJA8_HUMAN
Nuclear transcription factor Y subu...
NFYC
52Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MT00A0A0A0MT00_HUMAN
Nuclear transcription factor Y subu...
NFYC
179Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y803H0Y803_HUMAN
Nuclear transcription factor Y subu...
NFYC
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92212 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52M → I in CAA99055 (PubMed:9332362).Curated1
Sequence conflicti90D → N in BAA14051 (PubMed:10446203).Curated1
Sequence conflicti155V → L in AAC50816 (PubMed:8910521).Curated1
Sequence conflicti158Q → H in BAA14051 (PubMed:10446203).Curated1
Sequence conflicti171T → N in BAA14051 (PubMed:10446203).Curated1
Sequence conflicti175P → A in AAC50816 (PubMed:8910521).Curated1
Sequence conflicti179I → F in BAA14051 (PubMed:10446203).Curated1
Sequence conflicti198G → S in BAA12818 (PubMed:10446203).Curated1
Sequence conflicti198G → S in BAA14051 (PubMed:10446203).Curated1
Sequence conflicti202Q → K in BAA12818 (PubMed:10446203).Curated1
Sequence conflicti216 – 217QS → HN in BAA14051 (PubMed:10446203).Curated2
Sequence conflicti248L → V in AAC50816 (PubMed:8910521).Curated1
Sequence conflicti271A → V in AAC50816 (PubMed:8910521).Curated1
Sequence conflicti451Q → K in BAA14051 (PubMed:10446203).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035702165Q → H in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04334860 – 97Missing in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_043349186 – 219Missing in isoform 6. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_000851277 – 295Missing in isoform 1, isoform 2, isoform 4, isoform 6 and isoform 7. 8 PublicationsAdd BLAST19
Alternative sequenceiVSP_046350315Missing in isoform 7. 1 Publication1
Alternative sequenceiVSP_000852316 – 419Missing in isoform 1, isoform 4, isoform 5, isoform 6 and isoform 7. 8 PublicationsAdd BLAST104

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U62296 mRNA Translation: AAC50816.1
U78774 mRNA Translation: AAC51669.1
Z74792 mRNA Translation: CAA99055.1
D85425 mRNA Translation: BAA12818.1
D89986 mRNA Translation: BAA14051.1
AF191744 mRNA Translation: AAG28389.1
AK000346 mRNA Translation: BAA91100.1
AK127677 mRNA Translation: BAG54549.1
AK300774 mRNA Translation: BAG62438.1
AK301385 mRNA Translation: BAG62925.1
BT020081 mRNA Translation: AAV38884.1
AB208975 mRNA Translation: BAD92212.1 Different initiation.
AL031289 Genomic DNA No translation available.
AC119677 Genomic DNA No translation available.
AL354914 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07198.1
CH471059 Genomic DNA Translation: EAX07201.1
CH471059 Genomic DNA Translation: EAX07202.1
CH471059 Genomic DNA Translation: EAX07203.1
BC005003 mRNA Translation: AAH05003.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44120.1 [Q13952-5]
CCDS44121.1 [Q13952-7]
CCDS44122.1 [Q13952-6]
CCDS44123.1 [Q13952-4]
CCDS455.1 [Q13952-2]
CCDS81305.1 [Q13952-1]
CCDS81306.1 [Q13952-3]

NCBI Reference Sequences

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RefSeqi
NP_001136059.1, NM_001142587.1 [Q13952-7]
NP_001136060.1, NM_001142588.1 [Q13952-5]
NP_001136061.1, NM_001142589.1 [Q13952-4]
NP_001136062.1, NM_001142590.1 [Q13952-6]
NP_001295043.1, NM_001308114.1 [Q13952-1]
NP_001295044.1, NM_001308115.1 [Q13952-3]
NP_055038.2, NM_014223.4 [Q13952-2]
XP_005270951.1, XM_005270894.1 [Q13952-1]
XP_005270952.3, XM_005270895.3
XP_006710721.2, XM_006710658.2 [Q13952-3]
XP_006710723.2, XM_006710660.2 [Q13952-5]
XP_006710724.1, XM_006710661.1 [Q13952-3]
XP_006710725.2, XM_006710662.2
XP_011539818.1, XM_011541516.1 [Q13952-1]
XP_016856854.1, XM_017001365.1 [Q13952-1]
XP_016856856.1, XM_017001367.1 [Q13952-5]
XP_016856857.1, XM_017001368.1 [Q13952-2]
XP_016856858.1, XM_017001369.1 [Q13952-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.713051

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000308733; ENSP00000312617; ENSG00000066136 [Q13952-1]
ENST00000372651; ENSP00000361734; ENSG00000066136 [Q13952-2]
ENST00000372652; ENSP00000361736; ENSG00000066136 [Q13952-3]
ENST00000372653; ENSP00000361737; ENSG00000066136 [Q13952-6]
ENST00000372654; ENSP00000361738; ENSG00000066136 [Q13952-2]
ENST00000425457; ENSP00000396620; ENSG00000066136 [Q13952-5]
ENST00000427410; ENSP00000408315; ENSG00000066136 [Q13952-4]
ENST00000440226; ENSP00000414299; ENSG00000066136 [Q13952-2]
ENST00000447388; ENSP00000404427; ENSG00000066136 [Q13952-2]
ENST00000456393; ENSP00000408867; ENSG00000066136 [Q13952-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4802

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4802

UCSC genome browser

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UCSCi
uc001cfx.6 human [Q13952-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62296 mRNA Translation: AAC50816.1
U78774 mRNA Translation: AAC51669.1
Z74792 mRNA Translation: CAA99055.1
D85425 mRNA Translation: BAA12818.1
D89986 mRNA Translation: BAA14051.1
AF191744 mRNA Translation: AAG28389.1
AK000346 mRNA Translation: BAA91100.1
AK127677 mRNA Translation: BAG54549.1
AK300774 mRNA Translation: BAG62438.1
AK301385 mRNA Translation: BAG62925.1
BT020081 mRNA Translation: AAV38884.1
AB208975 mRNA Translation: BAD92212.1 Different initiation.
AL031289 Genomic DNA No translation available.
AC119677 Genomic DNA No translation available.
AL354914 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07198.1
CH471059 Genomic DNA Translation: EAX07201.1
CH471059 Genomic DNA Translation: EAX07202.1
CH471059 Genomic DNA Translation: EAX07203.1
BC005003 mRNA Translation: AAH05003.1
CCDSiCCDS44120.1 [Q13952-5]
CCDS44121.1 [Q13952-7]
CCDS44122.1 [Q13952-6]
CCDS44123.1 [Q13952-4]
CCDS455.1 [Q13952-2]
CCDS81305.1 [Q13952-1]
CCDS81306.1 [Q13952-3]
RefSeqiNP_001136059.1, NM_001142587.1 [Q13952-7]
NP_001136060.1, NM_001142588.1 [Q13952-5]
NP_001136061.1, NM_001142589.1 [Q13952-4]
NP_001136062.1, NM_001142590.1 [Q13952-6]
NP_001295043.1, NM_001308114.1 [Q13952-1]
NP_001295044.1, NM_001308115.1 [Q13952-3]
NP_055038.2, NM_014223.4 [Q13952-2]
XP_005270951.1, XM_005270894.1 [Q13952-1]
XP_005270952.3, XM_005270895.3
XP_006710721.2, XM_006710658.2 [Q13952-3]
XP_006710723.2, XM_006710660.2 [Q13952-5]
XP_006710724.1, XM_006710661.1 [Q13952-3]
XP_006710725.2, XM_006710662.2
XP_011539818.1, XM_011541516.1 [Q13952-1]
XP_016856854.1, XM_017001365.1 [Q13952-1]
XP_016856856.1, XM_017001367.1 [Q13952-5]
XP_016856857.1, XM_017001368.1 [Q13952-2]
XP_016856858.1, XM_017001369.1 [Q13952-2]
UniGeneiHs.713051

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N1JX-ray1.67B27-120[»]
4AWLX-ray3.08C27-120[»]
4CSRX-ray1.50B27-120[»]
ProteinModelPortaliQ13952
SMRiQ13952
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110868, 70 interactors
ComplexPortaliCPX-1956 CCAAT-binding factor complex
CORUMiQ13952
IntActiQ13952, 58 interactors
MINTiQ13952
STRINGi9606.ENSP00000396620

PTM databases

iPTMnetiQ13952
PhosphoSitePlusiQ13952

Polymorphism and mutation databases

BioMutaiNFYC
DMDMi20137773

Proteomic databases

EPDiQ13952
jPOSTiQ13952
MaxQBiQ13952
PaxDbiQ13952
PeptideAtlasiQ13952
PRIDEiQ13952
ProteomicsDBi59772
59773 [Q13952-2]
59774 [Q13952-3]
59775 [Q13952-4]
59776 [Q13952-5]
59777 [Q13952-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4802
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308733; ENSP00000312617; ENSG00000066136 [Q13952-1]
ENST00000372651; ENSP00000361734; ENSG00000066136 [Q13952-2]
ENST00000372652; ENSP00000361736; ENSG00000066136 [Q13952-3]
ENST00000372653; ENSP00000361737; ENSG00000066136 [Q13952-6]
ENST00000372654; ENSP00000361738; ENSG00000066136 [Q13952-2]
ENST00000425457; ENSP00000396620; ENSG00000066136 [Q13952-5]
ENST00000427410; ENSP00000408315; ENSG00000066136 [Q13952-4]
ENST00000440226; ENSP00000414299; ENSG00000066136 [Q13952-2]
ENST00000447388; ENSP00000404427; ENSG00000066136 [Q13952-2]
ENST00000456393; ENSP00000408867; ENSG00000066136 [Q13952-7]
GeneIDi4802
KEGGihsa:4802
UCSCiuc001cfx.6 human [Q13952-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4802
DisGeNETi4802
EuPathDBiHostDB:ENSG00000066136.19

GeneCards: human genes, protein and diseases

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GeneCardsi
NFYC
HGNCiHGNC:7806 NFYC
HPAiHPA055011
MIMi605344 gene
neXtProtiNX_Q13952
OpenTargetsiENSG00000066136
PharmGKBiPA31611

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1657 Eukaryota
COG5208 LUCA
GeneTreeiENSGT00940000155689
HOGENOMiHOG000231074
HOVERGENiHBG002885
InParanoidiQ13952
KOiK08066
OrthoDBi1558176at2759
PhylomeDBiQ13952
TreeFamiTF354207

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-380994 ATF4 activates genes
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
R-HSA-9614657 FOXO-mediated transcription of cell death genes
SIGNORiQ13952

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NFYC human
EvolutionaryTraceiQ13952

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NFYC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4802

Protein Ontology

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PROi
PR:Q13952

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000066136 Expressed in 236 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiQ13952 baseline and differential
GenevisibleiQ13952 HS

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
IPR027170 NFYC/HAP5_su
PANTHERiPTHR10252:SF8 PTHR10252:SF8, 1 hit
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFYC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13952
Secondary accession number(s): B4DUS6
, B4DW63, D3DPV9, F8VWM3, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: February 13, 2019
This is version 194 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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