Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 186 (07 Oct 2020)
Sequence version 2 (01 Nov 1997)
Previous versions | rss
Add a publicationFeedback
Protein

Core-binding factor subunit beta

Gene

CBFB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q13951

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8877330, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-8878166, Transcriptional regulation by RUNX2
R-HSA-8931987, RUNX1 regulates estrogen receptor mediated transcription
R-HSA-8934593, Regulation of RUNX1 Expression and Activity
R-HSA-8935964, RUNX1 regulates expression of components of tight junctions
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939242, RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8939245, RUNX1 regulates transcription of genes involved in BCR signaling
R-HSA-8939246, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-HSA-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling
R-HSA-8939256, RUNX1 regulates transcription of genes involved in WNT signaling
R-HSA-8939902, Regulation of RUNX2 expression and activity
R-HSA-8940973, RUNX2 regulates osteoblast differentiation
R-HSA-8941284, RUNX2 regulates chondrocyte maturation
R-HSA-8941326, RUNX2 regulates bone development
R-HSA-8941332, RUNX2 regulates genes involved in cell migration
R-HSA-8941333, RUNX2 regulates genes involved in differentiation of myeloid cells
R-HSA-8941858, Regulation of RUNX3 expression and activity
R-HSA-8949275, RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8951911, RUNX3 regulates RUNX1-mediated transcription
R-HSA-8951936, RUNX3 regulates p14-ARF
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9616222, Transcriptional regulation of granulopoiesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13951

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Core-binding factor subunit beta
Short name:
CBF-beta
Alternative name(s):
Polyomavirus enhancer-binding protein 2 beta subunit
Short name:
PEA2-beta
Short name:
PEBP2-beta
SL3-3 enhancer factor 1 subunit beta
SL3/AKV core-binding factor beta subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CBFB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000067955.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1539, CBFB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
121360, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13951

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei165 – 166Breakpoint for translocation to form CBF-beta-MYH11 oncogene in AML, subtype M4EO2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
865

MalaCards human disease database

More...
MalaCardsi
CBFB

Open Targets

More...
OpenTargetsi
ENSG00000067955

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98829, Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26114

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13951, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1615386

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CBFB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2498753

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000583011 – 182Core-binding factor subunit betaAdd BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q13951-2)
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei173PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13951

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13951

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q13951

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13951

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13951

PeptideAtlas

More...
PeptideAtlasi
Q13951

PRoteomics IDEntifications database

More...
PRIDEi
Q13951

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59770 [Q13951-1]
59771 [Q13951-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13951

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q13951

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13951

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000067955, Expressed in epithelium of mammary gland and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13951, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13951, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000067955, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with RUNX1, RUNX2 and RUNX3.

Interacts with COPRS.

Found in a complex with PRMT5 and RUNX1.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
107313, 37 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q13951

Database of interacting proteins

More...
DIPi
DIP-36772N

Protein interaction database and analysis system

More...
IntActi
Q13951, 35 interactors

Molecular INTeraction database

More...
MINTi
Q13951

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000415151

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q13951

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13951, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q13951

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13951

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13951

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CBF-beta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4785, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018132

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_074992_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13951

Identification of Orthologs from Complete Genome Data

More...
OMAi
PGKVHIK

Database of Orthologous Groups

More...
OrthoDBi
1254153at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13951

TreeFam database of animal gene trees

More...
TreeFami
TF314675

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.250.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003417, CBF_beta
IPR036552, CBF_bsu_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10276, PTHR10276, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02312, CBF_beta, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50723, SSF50723, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13951-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QARFQNACRD
60 70 80 90 100
GRSEIAFVAT GTNLSLQFFP ASWQGEQRQT PSREYVDLER EAGKVYLKAP
110 120 130 140 150
MILNGVCVIW KGWIDLQRLD GMGCLEFDEE RAQQEDALAQ QAFEEARRRT
160 170 180
REFEDRDRSH REEMEVRVSQ LLAVTGKKTT RP
Length:182
Mass (Da):21,508
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20FB1CC05FBFE4FB
GO
Isoform 2 (identifier: Q13951-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-182: VRVSQLLAVTGKKTTRP → ARRQQDPSPGSNLGGGDDLKLR

Show »
Length:187
Mass (Da):21,991
Checksum:i277B13D2A2ED18E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTD8J3KTD8_HUMAN
Core-binding factor subunit beta
CBFB
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSC0H3BSC0_HUMAN
Core-binding factor subunit beta
CBFB
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS23J3KS23_HUMAN
Core-binding factor subunit beta
CBFB
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRT0J3KRT0_HUMAN
Core-binding factor subunit beta
CBFB
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0A9A0A494C0A9_HUMAN
Core-binding factor subunit beta
CBFB
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036226100P → A in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1280921900Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036044166 – 182VRVSQ…KTTRP → ARRQQDPSPGSNLGGGDDLK LR in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF294326 mRNA Translation: AAG01553.1
BT006862 mRNA Translation: AAP35508.1
AK290462 mRNA Translation: BAF83151.1
CH471092 Genomic DNA Translation: EAW83067.1
CH471092 Genomic DNA Translation: EAW83068.1
BC018509 mRNA Translation: AAH18509.1
L20298 mRNA Translation: AAA02868.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10827.1 [Q13951-1]
CCDS45508.1 [Q13951-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A56840
I59579

NCBI Reference Sequences

More...
RefSeqi
NP_001746.1, NM_001755.2 [Q13951-1]
NP_074036.1, NM_022845.2 [Q13951-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290858; ENSP00000290858; ENSG00000067955 [Q13951-1]
ENST00000412916; ENSP00000415151; ENSG00000067955 [Q13951-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
865

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:865

UCSC genome browser

More...
UCSCi
uc002era.4, human [Q13951-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294326 mRNA Translation: AAG01553.1
BT006862 mRNA Translation: AAP35508.1
AK290462 mRNA Translation: BAF83151.1
CH471092 Genomic DNA Translation: EAW83067.1
CH471092 Genomic DNA Translation: EAW83068.1
BC018509 mRNA Translation: AAH18509.1
L20298 mRNA Translation: AAA02868.1
CCDSiCCDS10827.1 [Q13951-1]
CCDS45508.1 [Q13951-2]
PIRiA56840
I59579
RefSeqiNP_001746.1, NM_001755.2 [Q13951-1]
NP_074036.1, NM_022845.2 [Q13951-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CL3NMR-A4-141[»]
1E50X-ray2.60B/D/F/H2-135[»]
1H9DX-ray2.60B/D2-135[»]
4N9FX-ray3.300/6/F/L/N/R/a/c/i/k/o/u1-170[»]
6NILelectron microscopy3.90B/E/H/K1-151[»]
6P59X-ray2.94A/C1-165[»]
BMRBiQ13951
SMRiQ13951
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107313, 37 interactors
CORUMiQ13951
DIPiDIP-36772N
IntActiQ13951, 35 interactors
MINTiQ13951
STRINGi9606.ENSP00000415151

Chemistry databases

BindingDBiQ13951
ChEMBLiCHEMBL1615386

PTM databases

iPTMnetiQ13951
MetOSiteiQ13951
PhosphoSitePlusiQ13951

Polymorphism and mutation databases

BioMutaiCBFB
DMDMi2498753

Proteomic databases

EPDiQ13951
jPOSTiQ13951
MassIVEiQ13951
MaxQBiQ13951
PaxDbiQ13951
PeptideAtlasiQ13951
PRIDEiQ13951
ProteomicsDBi59770 [Q13951-1]
59771 [Q13951-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
15619, 396 antibodies

The DNASU plasmid repository

More...
DNASUi
865

Genome annotation databases

EnsembliENST00000290858; ENSP00000290858; ENSG00000067955 [Q13951-1]
ENST00000412916; ENSP00000415151; ENSG00000067955 [Q13951-2]
GeneIDi865
KEGGihsa:865
UCSCiuc002era.4, human [Q13951-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
865
DisGeNETi865
EuPathDBiHostDB:ENSG00000067955.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CBFB
HGNCiHGNC:1539, CBFB
HPAiENSG00000067955, Low tissue specificity
MalaCardsiCBFB
MIMi121360, gene
neXtProtiNX_Q13951
OpenTargetsiENSG00000067955
Orphaneti98829, Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
PharmGKBiPA26114

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4785, Eukaryota
GeneTreeiENSGT00390000018132
HOGENOMiCLU_074992_1_0_1
InParanoidiQ13951
OMAiPGKVHIK
OrthoDBi1254153at2759
PhylomeDBiQ13951
TreeFamiTF314675

Enzyme and pathway databases

PathwayCommonsiQ13951
ReactomeiR-HSA-8877330, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-8878166, Transcriptional regulation by RUNX2
R-HSA-8931987, RUNX1 regulates estrogen receptor mediated transcription
R-HSA-8934593, Regulation of RUNX1 Expression and Activity
R-HSA-8935964, RUNX1 regulates expression of components of tight junctions
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939242, RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8939245, RUNX1 regulates transcription of genes involved in BCR signaling
R-HSA-8939246, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-HSA-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling
R-HSA-8939256, RUNX1 regulates transcription of genes involved in WNT signaling
R-HSA-8939902, Regulation of RUNX2 expression and activity
R-HSA-8940973, RUNX2 regulates osteoblast differentiation
R-HSA-8941284, RUNX2 regulates chondrocyte maturation
R-HSA-8941326, RUNX2 regulates bone development
R-HSA-8941332, RUNX2 regulates genes involved in cell migration
R-HSA-8941333, RUNX2 regulates genes involved in differentiation of myeloid cells
R-HSA-8941858, Regulation of RUNX3 expression and activity
R-HSA-8949275, RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8951911, RUNX3 regulates RUNX1-mediated transcription
R-HSA-8951936, RUNX3 regulates p14-ARF
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9616222, Transcriptional regulation of granulopoiesis
SIGNORiQ13951

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
865, 82 hits in 894 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CBFB, human
EvolutionaryTraceiQ13951

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CBFB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
865
PharosiQ13951, Tchem

Protein Ontology

More...
PROi
PR:Q13951
RNActiQ13951, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000067955, Expressed in epithelium of mammary gland and 242 other tissues
ExpressionAtlasiQ13951, baseline and differential
GenevisibleiQ13951, HS

Family and domain databases

Gene3Di2.40.250.10, 1 hit
InterProiView protein in InterPro
IPR003417, CBF_beta
IPR036552, CBF_bsu_sf
PANTHERiPTHR10276, PTHR10276, 1 hit
PfamiView protein in Pfam
PF02312, CBF_beta, 1 hit
SUPFAMiSSF50723, SSF50723, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEBB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13951
Secondary accession number(s): A8K347, Q13124, Q9HCT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 7, 2020
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again