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Entry version 140 (12 Aug 2020)
Sequence version 2 (10 Jan 2006)
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Protein

Protein CASP

Gene

CUX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in intra-Golgi retrograde transport.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000170275-MONOMER

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q13948

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6811438, Intra-Golgi traffic

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q13948

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein CASP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CUX1
Synonyms:CUTL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000257923.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2557, CUX1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
116896, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13948

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 619CytoplasmicSequence analysisAdd BLAST619
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei620 – 640Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini641 – 678LumenalSequence analysisAdd BLAST38

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi624Y → L: Retained in the endoplasmic reticulum. 1 Publication1
Mutagenesisi629H → L: No effect on subcellular location. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1523

MalaCards human disease database

More...
MalaCardsi
CUX1

Open Targets

More...
OpenTargetsi
ENSG00000257923

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382924

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13948, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CUX1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85681028

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000717901 – 678Protein CASPAdd BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei586PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13948

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13948

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13948

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13948

PeptideAtlas

More...
PeptideAtlasi
Q13948

PRoteomics IDEntifications database

More...
PRIDEi
Q13948

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
32483
59765 [Q13948-1]
59766 [Q13948-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13948

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000257923, Expressed in secondary oocyte and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13948, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13948, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000257923, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.

Interacts with GOLGA5.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
107903, 76 interactors

Protein interaction database and analysis system

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IntActi
Q13948, 13 interactors

Molecular INTeraction database

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MINTi
Q13948

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13948

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili67 – 450Sequence analysisAdd BLAST384
Coiled coili502 – 556Sequence analysisAdd BLAST55

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CASP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159751

KEGG Orthology (KO)

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KOi
K09313

Database of Orthologous Groups

More...
OrthoDBi
181575at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012955, CASP_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08172, CASP_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 11 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 11 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q13948-1) [UniParc]FASTAAdd to basket
Also known as: CASP

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR
60 70 80 90 100
EFKKNTPEDL RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP
110 120 130 140 150
DPVPALDLGQ QLQLKVQRLH DIETENQKLR ETLEEYNKEF AEVKNQEVTI
160 170 180 190 200
KALKEKIREY EQTLKNQAET IALEKEQKLQ NDFAEKERKL QETQMSTTSK
210 220 230 240 250
LEEAEHKVQS LQTALEKTRT ELFDLKTKYD EETTAKADEI EMIMTDLERA
260 270 280 290 300
NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE
310 320 330 340 350
VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLSAKNSTLK
360 370 380 390 400
QLEEKLKGQA DYEEVKKELN ILKSMEFAPS EGAGTQDAAK PLEVLLLEKN
410 420 430 440 450
RSLQSENAAL RISNSDLSGR CAELQVRITE AVATATEQRE LIARLEQDLS
460 470 480 490 500
IIQSIQRPDA EGAAEHRLEK IPEPIKEATA LFYGPAAPAS GALPEGQVDS
510 520 530 540 550
LLSIISSQRE RFRARNQELE AENRLAQHTL QALQSELDSL RADNIKLFEK
560 570 580 590 600
IKFLQSYPGR GSGSDDTELR YSSQYEERLD PFSSFSKRER QRKYLSLSPW
610 620 630 640 650
DKATLSMGRL VLSNKMARTI GFFYTLFLHC LVFLVLYKLA WSESMERDCA
660 670
TFCAKKFADH LHKFHENDNG AAAGDLWQ
Length:678
Mass (Da):77,455
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE587F222825EA47E
GO
Isoform 11 (identifier: P39880-9) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:632
Mass (Da):72,024
GO
Isoform 1 (identifier: P39880-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,505
Mass (Da):164,187
GO
Isoform 2 (identifier: P39880-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,483
Mass (Da):161,650
GO
Isoform 3 (identifier: P39880-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,516
Mass (Da):165,688
GO
Isoform 5 (identifier: P39880-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,403
Mass (Da):153,364
GO
Isoform 6 (identifier: P39880-5) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,449
Mass (Da):157,895
GO
Isoform 7 (identifier: P39880-6) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,347
Mass (Da):147,072
GO
Isoform 8 (identifier: Q13948-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     288-289: Missing.

Show »
Length:676
Mass (Da):77,198
Checksum:i727AC64B50C59153
GO
Isoform 9 (identifier: Q13948-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-58: Missing.
     288-289: Missing.

Show »
Length:639
Mass (Da):72,841
Checksum:i92BB146A2065C5CE
GO
Isoform 10 (identifier: Q13948-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-73: Missing.

Show »
Length:662
Mass (Da):75,644
Checksum:iCBAF60CA80A21247
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y852A0A2R8Y852_HUMAN
Homeobox protein cut-like
CUX1
1,460Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDI1A0A2R8YDI1_HUMAN
Homeobox protein cut-like
CUX1
1,358Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y8D0A0A2R8Y8D0_HUMAN
Protein CASP
CUX1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti407N → S in AAH25422 (PubMed:15489334).Curated1
Sequence conflicti455I → V in BAG64254 (PubMed:14702039).Curated1
Sequence conflicti525L → V in BAG64254 (PubMed:14702039).Curated1
Sequence conflicti551I → V in BAD96552 (Ref. 3) Curated1
Sequence conflicti613S → P in BAG54140 (PubMed:14702039).Curated1
Sequence conflicti657F → L in AAA35654 (PubMed:9332351).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024923464A → T2 PublicationsCorresponds to variant dbSNP:rs803064Ensembl.1
Natural variantiVAR_036285490S → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024924545I → V1 PublicationCorresponds to variant dbSNP:rs2230103Ensembl.1
Natural variantiVAR_036286609R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1287689842Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04559322 – 58Missing in isoform 9. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_04592758 – 73Missing in isoform 10. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_040094288 – 289Missing in isoform 8 and isoform 9. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L12579 mRNA Translation: AAA35654.1
AK125076 mRNA Translation: BAG54135.1
AK125097 mRNA Translation: BAG54140.1
AK303151 mRNA Translation: BAG64254.1
AK222832 mRNA Translation: BAD96552.1
AC005072 Genomic DNA No translation available.
AC005086 Genomic DNA Translation: AAP22331.1
AC005088 Genomic DNA No translation available.
AC005096 Genomic DNA Translation: AAS07410.1
AC005103 Genomic DNA Translation: AAS07388.1
AC092788 Genomic DNA Translation: AAS07523.1
CH471197 Genomic DNA Translation: EAW50227.1
BC025422 mRNA Translation: AAH25422.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47672.1 [Q13948-2]
CCDS56500.1 [Q13948-10]
CCDS5720.1 [Q13948-1]
CCDS59071.1 [Q13948-9]

NCBI Reference Sequences

More...
RefSeqi
NP_001189473.1, NM_001202544.2 [Q13948-10]
NP_001189474.1, NM_001202545.2
NP_001189475.1, NM_001202546.2 [Q13948-9]
NP_001904.2, NM_001913.4 [Q13948-1]
NP_852477.1, NM_181500.3 [Q13948-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292538; ENSP00000292538; ENSG00000257923 [Q13948-1]
ENST00000393824; ENSP00000377410; ENSG00000257923 [Q13948-9]
ENST00000437600; ENSP00000414091; ENSG00000257923 [Q13948-2]
ENST00000547394; ENSP00000449371; ENSG00000257923 [Q13948-10]
ENST00000622516; ENSP00000484760; ENSG00000257923 [Q13948-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1523

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1523

UCSC genome browser

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UCSCi
uc003uyt.4, human [Q13948-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12579 mRNA Translation: AAA35654.1
AK125076 mRNA Translation: BAG54135.1
AK125097 mRNA Translation: BAG54140.1
AK303151 mRNA Translation: BAG64254.1
AK222832 mRNA Translation: BAD96552.1
AC005072 Genomic DNA No translation available.
AC005086 Genomic DNA Translation: AAP22331.1
AC005088 Genomic DNA No translation available.
AC005096 Genomic DNA Translation: AAS07410.1
AC005103 Genomic DNA Translation: AAS07388.1
AC092788 Genomic DNA Translation: AAS07523.1
CH471197 Genomic DNA Translation: EAW50227.1
BC025422 mRNA Translation: AAH25422.1
CCDSiCCDS47672.1 [Q13948-2]
CCDS56500.1 [Q13948-10]
CCDS5720.1 [Q13948-1]
CCDS59071.1 [Q13948-9]
RefSeqiNP_001189473.1, NM_001202544.2 [Q13948-10]
NP_001189474.1, NM_001202545.2
NP_001189475.1, NM_001202546.2 [Q13948-9]
NP_001904.2, NM_001913.4 [Q13948-1]
NP_852477.1, NM_181500.3 [Q13948-2]

3D structure databases

SMRiQ13948
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107903, 76 interactors
IntActiQ13948, 13 interactors
MINTiQ13948

PTM databases

iPTMnetiQ13948

Polymorphism and mutation databases

BioMutaiCUX1
DMDMi85681028

Proteomic databases

EPDiQ13948
jPOSTiQ13948
MassIVEiQ13948
MaxQBiQ13948
PeptideAtlasiQ13948
PRIDEiQ13948
ProteomicsDBi32483
59765 [Q13948-1]
59766 [Q13948-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
48390, 392 antibodies

The DNASU plasmid repository

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DNASUi
1523

Genome annotation databases

EnsembliENST00000292538; ENSP00000292538; ENSG00000257923 [Q13948-1]
ENST00000393824; ENSP00000377410; ENSG00000257923 [Q13948-9]
ENST00000437600; ENSP00000414091; ENSG00000257923 [Q13948-2]
ENST00000547394; ENSP00000449371; ENSG00000257923 [Q13948-10]
ENST00000622516; ENSP00000484760; ENSG00000257923 [Q13948-1]
GeneIDi1523
KEGGihsa:1523
UCSCiuc003uyt.4, human [Q13948-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1523
DisGeNETi1523
EuPathDBiHostDB:ENSG00000257923.9

GeneCards: human genes, protein and diseases

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GeneCardsi
CUX1
HGNCiHGNC:2557, CUX1
HPAiENSG00000257923, Low tissue specificity
MalaCardsiCUX1
MIMi116896, gene
neXtProtiNX_Q13948
OpenTargetsiENSG00000257923
PharmGKBiPA162382924

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00940000159751
KOiK09313
OrthoDBi181575at2759

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000170275-MONOMER
PathwayCommonsiQ13948
ReactomeiR-HSA-6811438, Intra-Golgi traffic
SignaLinkiQ13948

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
1523, 10 hits in 904 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CUX1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1523
PharosiQ13948, Tbio

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000257923, Expressed in secondary oocyte and 246 other tissues
ExpressionAtlasiQ13948, baseline and differential
GenevisibleiQ13948, HS

Family and domain databases

InterProiView protein in InterPro
IPR012955, CASP_C
PfamiView protein in Pfam
PF08172, CASP_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13948
Secondary accession number(s): B3KWH3
, B3KWH8, B4DZZ2, G3V1Z6, J3KPQ6, Q53GU9, Q8TBS3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: August 12, 2020
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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