We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q13938 (CAYP1_HUMAN)
Protein
Calcyphosin
Gene
CAPS
Organism
Homo sapiens (Human)
Status
Functioni
Calcium-binding protein. May play a role in cellular signaling events (Potential).
CuratedSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 120 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 122 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 124 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 126 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 131 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 156 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 158 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 160 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 162 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 167 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 192 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 194 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 196 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 203 | Calcium 3PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: ProtInc
GO - Biological processi
- intracellular signal transduction Source: ProtInc
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q13938 |
SignaLinki | Q13938 |
Names & Taxonomyi
Protein namesi | Recommended name: CalcyphosinAlternative name(s): Calcyphosine |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1487, CAPS |
MIMi | 114212, gene |
neXtProti | NX_Q13938 |
VEuPathDBi | HostDB:ENSG00000105519 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 828 |
OpenTargetsi | ENSG00000105519 |
PharmGKBi | PA26068 |
Miscellaneous databases
Pharosi | Q13938, Tbio |
Chemistry databases
DrugBanki | DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate |
Genetic variation databases
BioMutai | CAPS |
DMDMi | 2493439 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073538 | 1 – 275 | CalcyphosinAdd BLAST | 275 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 126 | Phosphoserine; by PKASequence analysis | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-179 CPTAC-180 |
jPOSTi | Q13938 |
MassIVEi | Q13938 |
MaxQBi | Q13938 |
PaxDbi | Q13938 |
PeptideAtlasi | Q13938 |
PRIDEi | Q13938 |
ProteomicsDBi | 59760 [Q13938-1] |
PTM databases
GlyGeni | Q13938, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q13938 |
PhosphoSitePlusi | Q13938 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105519, Expressed in right uterine tube and 141 other tissues |
ExpressionAtlasi | Q13938, baseline and differential |
Genevisiblei | Q13938, HS |
Organism-specific databases
HPAi | ENSG00000105519, Group enriched (brain, fallopian tube) |
Interactioni
Subunit structurei
Monomer. Does not form oligomers in the presence of calcium.
1 PublicationProtein-protein interaction databases
BioGRIDi | 107278, 22 interactors |
IntActi | Q13938, 3 interactors |
STRINGi | 9606.ENSP00000484912 |
Miscellaneous databases
RNActi | Q13938, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q13938 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13938 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 107 – 142 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 143 – 178 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 179 – 214 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 222 – 258 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 37 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 59 – 87 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 59 – 82 | Polar residuesSequence analysisAdd BLAST | 24 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0032, Eukaryota |
GeneTreei | ENSGT00940000162442 |
HOGENOMi | CLU_036726_1_0_1 |
InParanoidi | Q13938 |
OMAi | DAHDKDG |
OrthoDBi | 1377102at2759 |
PhylomeDBi | Q13938 |
TreeFami | TF318191 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 4 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q13938-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQCHRDLALS QALWGWQLSK QSGWAHPSLP HSPLPSTVHS CSWAPPHLQR
60 70 80 90 100
HLPLATVSPG TTQLTQGPAG RTLGQTQASC PEPRPSMDAV DATMEKLRAQ
110 120 130 140 150
CLSRGASGIQ GLARFFRQLD RDGSRSLDAD EFRQGLAKLG LVLDQAEAEG
160 170 180 190 200
VCRKWDRNGS GTLDLEEFLR ALRPPMSQAR EAVIAAAFAK LDRSGDGVVT
210 220 230 240 250
VDDLRGVYSG RAHPKVRSGE WTEDEVLRRF LDNFDSSEKD GQVTLAEFQD
260 270
YYSGVSASMN TDEEFVAMMT SAWQL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ES72 | K7ES72_HUMAN | Calcyphosin | CAPS | 134 | Annotation score: | ||
A0A499FJ41 | A0A499FJ41_HUMAN | Calcyphosin | CAPS hCG_23051 | 162 | Annotation score: |
Sequence cautioni
The sequence AAC14484 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH80599 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC03450 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048638 | 125 | R → G. Corresponds to variant dbSNP:rs7249419Ensembl. | 1 | |
Natural variantiVAR_080772 | 180 | R → Q Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs375700493Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059695 | 1 – 86 | Missing in isoform 3. 1 PublicationAdd BLAST | 86 | |
Alternative sequenceiVSP_055154 | 217 – 243 | Missing in isoform 2. 1 PublicationAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090469 mRNA Translation: BAC03450.1 Different initiation. AC004602 Genomic DNA Translation: AAC14484.1 Different initiation. AC104532 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69126.1 CH471139 Genomic DNA Translation: EAW69128.1 BC019065 mRNA No translation available. BC080599 mRNA Translation: AAH80599.1 Different initiation. BC101513 mRNA Translation: AAI01514.1 BC104766 mRNA Translation: AAI04767.1 X97966 mRNA Translation: CAA66609.1 |
CCDSi | CCDS12156.2 [Q13938-4] |
RefSeqi | NP_004049.2, NM_004058.4 [Q13938-4] NP_542157.2, NM_080590.3 |
Genome annotation databases
Ensembli | ENST00000588776; ENSP00000465883; ENSG00000105519 [Q13938-4] |
GeneIDi | 828 |
KEGGi | hsa:828 |
MANE-Selecti | ENST00000588776.8; ENSP00000465883.2; NM_004058.5; NP_004049.3 [Q13938-4] |
UCSCi | uc002mdt.4, human [Q13938-1] uc060seu.1, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090469 mRNA Translation: BAC03450.1 Different initiation. AC004602 Genomic DNA Translation: AAC14484.1 Different initiation. AC104532 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69126.1 CH471139 Genomic DNA Translation: EAW69128.1 BC019065 mRNA No translation available. BC080599 mRNA Translation: AAH80599.1 Different initiation. BC101513 mRNA Translation: AAI01514.1 BC104766 mRNA Translation: AAI04767.1 X97966 mRNA Translation: CAA66609.1 |
CCDSi | CCDS12156.2 [Q13938-4] |
RefSeqi | NP_004049.2, NM_004058.4 [Q13938-4] NP_542157.2, NM_080590.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3E3R | X-ray | 2.65 | A/B | 87-275 | [»] | |
SMRi | Q13938 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107278, 22 interactors |
IntActi | Q13938, 3 interactors |
STRINGi | 9606.ENSP00000484912 |
Chemistry databases
DrugBanki | DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate |
PTM databases
GlyGeni | Q13938, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q13938 |
PhosphoSitePlusi | Q13938 |
Genetic variation databases
BioMutai | CAPS |
DMDMi | 2493439 |
Proteomic databases
CPTACi | CPTAC-179 CPTAC-180 |
jPOSTi | Q13938 |
MassIVEi | Q13938 |
MaxQBi | Q13938 |
PaxDbi | Q13938 |
PeptideAtlasi | Q13938 |
PRIDEi | Q13938 |
ProteomicsDBi | 59760 [Q13938-1] |
Protocols and materials databases
Antibodypediai | 24025, 135 antibodies from 23 providers |
DNASUi | 828 |
Genome annotation databases
Ensembli | ENST00000588776; ENSP00000465883; ENSG00000105519 [Q13938-4] |
GeneIDi | 828 |
KEGGi | hsa:828 |
MANE-Selecti | ENST00000588776.8; ENSP00000465883.2; NM_004058.5; NP_004049.3 [Q13938-4] |
UCSCi | uc002mdt.4, human [Q13938-1] uc060seu.1, human |
Organism-specific databases
CTDi | 828 |
DisGeNETi | 828 |
GeneCardsi | CAPS |
HGNCi | HGNC:1487, CAPS |
HPAi | ENSG00000105519, Group enriched (brain, fallopian tube) |
MIMi | 114212, gene |
neXtProti | NX_Q13938 |
OpenTargetsi | ENSG00000105519 |
PharmGKBi | PA26068 |
VEuPathDBi | HostDB:ENSG00000105519 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0032, Eukaryota |
GeneTreei | ENSGT00940000162442 |
HOGENOMi | CLU_036726_1_0_1 |
InParanoidi | Q13938 |
OMAi | DAHDKDG |
OrthoDBi | 1377102at2759 |
PhylomeDBi | Q13938 |
TreeFami | TF318191 |
Enzyme and pathway databases
PathwayCommonsi | Q13938 |
SignaLinki | Q13938 |
Miscellaneous databases
BioGRID-ORCSi | 828, 27 hits in 1045 CRISPR screens |
ChiTaRSi | CAPS, human |
EvolutionaryTracei | Q13938 |
GeneWikii | CAPS_(gene) |
GenomeRNAii | 828 |
Pharosi | Q13938, Tbio |
PROi | PR:Q13938 |
RNActi | Q13938, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105519, Expressed in right uterine tube and 141 other tissues |
ExpressionAtlasi | Q13938, baseline and differential |
Genevisiblei | Q13938, HS |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CAYP1_HUMAN | |
Accessioni | Q13938Primary (citable) accession number: Q13938 Secondary accession number(s): A0A0X1KG78 Q8WUZ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | September 12, 2018 | |
Last modified: | February 23, 2022 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references