CAPS

Functionⁱ

Calcium-binding protein. May play a role in cellular signaling events (Potential).Curated

Regions

Feature key	Position(s)	DescriptionActions	Length
Calcium bindingⁱ	120 – 131	1Add BLAST	12
Calcium bindingⁱ	156 – 167	2Add BLAST	12
Calcium bindingⁱ	192 – 203	3Add BLAST	12
Calcium bindingⁱ	235 – 247	4Add BLAST	13

GO - Molecular functionⁱ

calcium ion binding
Source: ProtInc
Traceable author statementⁱ
- 2540953

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular signal transduction
Source: ProtInc
Traceable author statementⁱ
- 2540953

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Metal-binding

Ligand

Calcium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Calcyphosin Alternative name(s): Calcyphosine
Gene namesⁱ	Name:CAPS1 PublicationImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105519.13 HostDB:ENSG00000283027.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1487 CAPS
MIMⁱ	114212 gene
neXtProtⁱ	NX_Q13938

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	828
Open Targets More...OpenTargetsⁱ	ENSG00000105519
PharmGKBⁱ	PA26068

Polymorphism and mutation databases

BioMutaⁱ	CAPS
DMDMⁱ	2493439

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000073538	1 – 275	CalcyphosinAdd BLAST		275

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	126	Phosphoserine; by PKASequence analysis		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13938
PaxDbⁱ	Q13938
PeptideAtlas More...PeptideAtlasⁱ	Q13938
PRIDEⁱ	Q13938
ProteomicsDBⁱ	59760

PTM databases

iPTMnetⁱ	Q13938
PhosphoSitePlusⁱ	Q13938

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000105519 Expressed in 121 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_CAPS
Genevisibleⁱ	Q13938 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043520

HPAⁱ

HPA043520

Interactionⁱ

Subunit structureⁱ

Monomer. Does not form oligomers in the presence of calcium.1 Publication

Protein-protein interaction databases

BioGridⁱ	107278, 17 interactors
STRINGⁱ	9606.ENSP00000222125

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	88 – 98	Combined sources	11
Turnⁱ	102 – 104	Combined sources	3
Helixⁱ	114 – 119	Combined sources	6
Beta strandⁱ	125 – 127	Combined sources	3
Helixⁱ	129 – 137	Combined sources	9
Turnⁱ	138 – 140	Combined sources	3
Helixⁱ	145 – 155	Combined sources	11
Beta strandⁱ	160 – 163	Combined sources	4
Helixⁱ	165 – 171	Combined sources	7
Helixⁱ	178 – 191	Combined sources	14
Beta strandⁱ	196 – 199	Combined sources	4
Helixⁱ	201 – 207	Combined sources	7
Helixⁱ	214 – 217	Combined sources	4
Helixⁱ	223 – 234	Combined sources	12
Helixⁱ	245 – 258	Combined sources	14
Helixⁱ	262 – 273	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13938
SMRⁱ	Q13938
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13938

EvolutionaryTraceⁱ

Q13938

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	107 – 142	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	143 – 178	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	179 – 214	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	222 – 258	EF-hand 4PROSITE-ProRule annotationAdd BLAST	37

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota ENOG410XRMJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000679
HOGENOMⁱ	HOG000008004
HOVERGENⁱ	HBG050808
InParanoidⁱ	Q13938
OMAⁱ	MDTDEEF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PLN
PhylomeDBⁱ	Q13938
TreeFamⁱ	TF318191

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051 EFh, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 2 hits
SMARTⁱ	View protein in SMART SM00054 EFh, 4 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 3 hits PS50222 EF_HAND_2, 4 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q13938-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQCHRDLALS QALWGWQLSK QSGWAHPSLP HSPLPSTVHS CSWAPPHLQR 
        60         70         80         90        100
HLPLATVSPG TTQLTQGPAG RTLGQTQASC PEPRPSMDAV DATMEKLRAQ 
       110        120        130        140        150
CLSRGASGIQ GLARFFRQLD RDGSRSLDAD EFRQGLAKLG LVLDQAEAEG 
       160        170        180        190        200
VCRKWDRNGS GTLDLEEFLR ALRPPMSQAR EAVIAAAFAK LDRSGDGVVT 
       210        220        230        240        250
VDDLRGVYSG RAHPKVRSGE WTEDEVLRRF LDNFDSSEKD GQVTLAEFQD 
       260        270 
YYSGVSASMN TDEEFVAMMT SAWQL

Length:275

Mass (Da):30,240

Last modified:September 12, 2018 - v2

Checksum:ⁱEF8DF483ED4F7FD9

GO

Isoform 2 (identifier: Q13938-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
217-243: Missing.

« Hide

        10         20         30         40         50
MQCHRDLALS QALWGWQLSK QSGWAHPSLP HSPLPSTVHS CSWAPPHLQR 
        60         70         80         90        100
HLPLATVSPG TTQLTQGPAG RTLGQTQASC PEPRPSMDAV DATMEKLRAQ 
       110        120        130        140        150
CLSRGASGIQ GLARFFRQLD RDGSRSLDAD EFRQGLAKLG LVLDQAEAEG 
       160        170        180        190        200
VCRKWDRNGS GTLDLEEFLR ALRPPMSQAR EAVIAAAFAK LDRSGDGVVT 
       210        220        230        240 
VDDLRGVYSG RAHPKVTLAE FQDYYSGVSA SMNTDEEFVA MMTSAWQL

Note: No experimental confirmation available.

Show »

Length:248

Mass (Da):27,042

Checksum:ⁱ5FDA9346B8F4C086

GO

Isoform 3 (identifier: Q13938-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-86: Missing.

« Hide

        10         20         30         40         50
MDAVDATMEK LRAQCLSRGA SGIQGLARFF RQLDRDGSRS LDADEFRQGL 
        60         70         80         90        100
AKLGLVLDQA EAEGVCRKWD RNGSGTLDLE EFLRALRPPM SQAREAVIAA 
       110        120        130        140        150
AFAKLDRSGD GVVTVDDLRG VYSGRAHPKV RSGEWTEDEV LRRFLDNFDS 
       160        170        180 
SEKDGQVTLA EFQDYYSGVS ASMNTDEEFV AMMTSAWQL

Show »

Length:189

Mass (Da):20,967

Checksum:ⁱE57291A996D7D1D5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	K7ES72	K7ES72_HUMAN		Calcyphosin Calcyphosin	CAPS	134	Annotation score:

Sequence cautionⁱ

The sequence AAC14484 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH80599 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC03450 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048638	125	R → G. Corresponds to variant dbSNP:rs7249419Ensembl.		1
Natural variantⁱVAR_080772	180	R → Q Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_059695	1 – 86	Missing in isoform 3. 1 PublicationAdd BLAST		86
Alternative sequenceⁱVSP_055154	217 – 243	Missing in isoform 2. 1 PublicationAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK090469 mRNA Translation: BAC03450.1 Different initiation. AC004602 Genomic DNA Translation: AAC14484.1 Different initiation. AC104532 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69126.1 CH471139 Genomic DNA Translation: EAW69128.1 BC019065 mRNA No translation available. BC080599 mRNA Translation: AAH80599.1 Different initiation. BC101513 mRNA Translation: AAI01514.1 BC104766 mRNA Translation: AAI04767.1 X97966 mRNA Translation: CAA66609.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004049.2, NM_004058.4 [Q13938-1] NP_542157.2, NM_080590.3 [Q13938-3]
UniGeneⁱ	Hs.584744 Hs.627868

Genome annotation databases

Ensemblⁱ	ENST00000452990; ENSP00000403263; ENSG00000105519 [Q13938-3] ENST00000588776; ENSP00000465883; ENSG00000105519 [Q13938-1]
GeneIDⁱ	828
KEGGⁱ	hsa:828
UCSC genome browser More...UCSCⁱ	uc002mdt.4 human [Q13938-1] uc060seu.1 human

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13938	Uncharacterized protein		PANPA		275	UniRef100_Q13938
Q13938-4	Calcyphosine		PANTR		189	UniRef100_K7BWI1
Similar to calcyphosine (Fragment)		HUMAN		164
UPI0006C9C857		PANPA		277
Calcyphosin (Fragment)		HUMAN		134
CAPS isoform 5 (Fragment)		PANTR		134

Protein	Similar proteins		Species	Score	Length	Source
Q13938	Uncharacterized protein		PANPA		275	UniRef90_Q13938
CAPS isoform 1		PANTR		275
Uncharacterized protein		MACMU		274
Uncharacterized protein		PAPAN		274
Uncharacterized protein		MACFA		274
+16
Q13938-3	CAPS isoform 2		PONAB		250	UniRef90_Q13938-3
CAPS isoform 2		PANTR		248
UPI0008F4C382		GORGO		282
UPI0000070347		HUMAN		162

Protein	Similar proteins		Species	Score	Length	Source
Q13938	Uncharacterized protein		PANPA		275	UniRef50_Q13938
CAPS isoform 1		PANTR		275
Uncharacterized protein		MACMU		274
Uncharacterized protein		MACFA		274
Uncharacterized protein		PAPAN		274
+36
Q13938-3	Calcyphosin		CANLF		189	UniRef50_Q13938-3
CAPS isoform 2		PONAB		250
CAPS isoform 2		PANTR		248
Uncharacterized protein		Cebus capucinus imitator		237
Uncharacterized protein		COLAP		285
+61

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK090469 mRNA Translation: BAC03450.1 Different initiation. AC004602 Genomic DNA Translation: AAC14484.1 Different initiation. AC104532 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69126.1 CH471139 Genomic DNA Translation: EAW69128.1 BC019065 mRNA No translation available. BC080599 mRNA Translation: AAH80599.1 Different initiation. BC101513 mRNA Translation: AAI01514.1 BC104766 mRNA Translation: AAI04767.1 X97966 mRNA Translation: CAA66609.1
RefSeqⁱ	NP_004049.2, NM_004058.4 [Q13938-1] NP_542157.2, NM_080590.3 [Q13938-3]
UniGeneⁱ	Hs.584744 Hs.627868

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3E3R	X-ray	2.65	A/B	87-275	[»]
ProteinModelPortalⁱ	Q13938
SMRⁱ	Q13938
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107278, 17 interactors
STRINGⁱ	9606.ENSP00000222125

PTM databases

iPTMnetⁱ	Q13938
PhosphoSitePlusⁱ	Q13938

Polymorphism and mutation databases

BioMutaⁱ	CAPS
DMDMⁱ	2493439

Proteomic databases

MaxQBⁱ	Q13938
PaxDbⁱ	Q13938
PeptideAtlasⁱ	Q13938
PRIDEⁱ	Q13938
ProteomicsDBⁱ	59760

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000452990; ENSP00000403263; ENSG00000105519 [Q13938-3] ENST00000588776; ENSP00000465883; ENSG00000105519 [Q13938-1]
GeneIDⁱ	828
KEGGⁱ	hsa:828
UCSCⁱ	uc002mdt.4 human [Q13938-1] uc060seu.1 human

Organism-specific databases

CTDⁱ	828
DisGeNETⁱ	828
EuPathDBⁱ	HostDB:ENSG00000105519.13 HostDB:ENSG00000283027.1
GeneCardsⁱ	CAPS
HGNCⁱ	HGNC:1487 CAPS
HPAⁱ	HPA043520
MIMⁱ	114212 gene
neXtProtⁱ	NX_Q13938
OpenTargetsⁱ	ENSG00000105519
PharmGKBⁱ	PA26068
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota ENOG410XRMJ LUCA
GeneTreeⁱ	ENSGT00390000000679
HOGENOMⁱ	HOG000008004
HOVERGENⁱ	HBG050808
InParanoidⁱ	Q13938
OMAⁱ	MDTDEEF
OrthoDBⁱ	EOG091G0PLN
PhylomeDBⁱ	Q13938
TreeFamⁱ	TF318191

Miscellaneous databases

ChiTaRSⁱ	CAPS human
EvolutionaryTraceⁱ	Q13938
GeneWikiⁱ	CAPS_(gene)
GenomeRNAiⁱ	828
Protein Ontology More...PROⁱ	PR:Q13938
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105519 Expressed in 121 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_CAPS
Genevisibleⁱ	Q13938 HS

Family and domain databases

CDDⁱ	cd00051 EFh, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 2 hits
SMARTⁱ	View protein in SMART SM00054 EFh, 4 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 3 hits PS50222 EF_HAND_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAYP1_HUMAN
Accessionⁱ	Q13938Primary (citable) accession number: Q13938 Secondary accession number(s): A0A0X1KG78 , K7EL21, Q3MJA7, Q8NF12, Q8WUZ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	September 12, 2018
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - Q13938 (CAYP1_HUMAN)

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Calcyphosin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ