UniProtKB - Q13936 (CAC1C_HUMAN)
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- BLAST>sp|Q13936|CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C OS=Homo sapiens OX=9606 GN=CACNA1C PE=1 SV=4 MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAAR QAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISI VEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIA YGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFR VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYN QEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCI TMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGD FQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVA GGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLT IASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGI LETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFL FIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG GPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLAR TASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNP ETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDT IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVF TSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVL RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSD SSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPEL LYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNC ELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVIL SETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFR VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTE INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFA VFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRI KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRI KTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFK KRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASE DDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDST FTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLS SNRERHVPMCEDLELRRDSGSAGTQAHCLLLRKANPSRCHSRESQAAMAGQEETSQDETY EVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRA SFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPA TPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLM VPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESA ADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGRPSEEELQDSRVYVSS L
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Protein
Voltage-dependent L-type calcium channel subunit alpha-1C
Gene
CACNA1C
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:
Annotation score:5 out of 5
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>Select a section on the left to see content.
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).By similarity
<p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi
Curated21 Publications<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.2"Cloning, chromosomal localization, and functional expression of the alpha-1 subunit of the L-type voltage-dependent calcium channel from normal human heart."
Schultz D., Mikala G., Yatani A., Engle D.B., Iles D.E., Segers B., Sinke R.J., Weghuis D.O., Kloeckner U., Wakamori M., Wang J.-J., Melvin D., Varadi G., Schwartz A.
Proc. Natl. Acad. Sci. U.S.A. 90:6228-6232(1993) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 18 AND 28), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1822-1863, FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ARG-84. - Ref.4"Different voltage-dependent inhibition by dihydropyridines of human Ca2+ channel splice variants."
Soldatov N.M., Bouron A., Reuter H.
J. Biol. Chem. 270:10540-10543(1995) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 12; 19 AND 20), ALTERNATIVE SPLICING, FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-954 AND TYR-958. - Ref.5"Properties of three COOH-terminal splice variants of a human cardiac L-type Ca2+-channel alpha1-subunit."
Kloeckner U., Mikala G., Eisfeld J., Iles D.E., Strobeck M., Mershon J.L., Schwartz A., Varadi G.
Am. J. Physiol. 272:H1372-H1381(1997) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 16 AND 17), ALTERNATIVE SPLICING, FUNCTION, SUBCELLULAR LOCATION, VARIANTS ARG-84; VAL-1869 AND ARG-1893. - Ref.6"Molecular structures involved in L-type calcium channel inactivation. Role of the carboxyl-terminal region encoded by exons 40-42 in alpha1C subunit in the kinetics and Ca2+ dependence of inactivation."
Soldatov N.M., Zuelke R.D., Bouron A., Reuter H.
J. Biol. Chem. 272:3560-3566(1997) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 26 AND 27), ALTERNATIVE SPLICING (ISOFORMS 9 AND 10), FUNCTION, SUBCELLULAR LOCATION. - Ref.7"Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene."
Zuehlke R.D., Bouron A., Soldatov N.M., Reuter H.
FEBS Lett. 427:220-224(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 21; 22 AND 23), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION. - Ref.8"Alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulation."
Lyford G.L., Strege P.R., Shepard A., Ou Y., Ermilov L., Miller S.M., Gibbons S.J., Rae J.L., Szurszewski J.H., Farrugia G.
Am. J. Physiol. 283:C1001-C1008(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH CACNB2, TISSUE SPECIFICITY. - Ref.9"Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit."
Tiwari S., Zhang Y., Heller J., Abernethy D.R., Soldatov N.M.
Proc. Natl. Acad. Sci. U.S.A. 103:17024-17029(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 13; 14; 15; 24 AND 25), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. - Ref.13"A novel long N-terminal isoform of human L-type Ca2+ channel is up-regulated by protein kinase C."
Blumenstein Y., Kanevsky N., Sahar G., Barzilai R., Ivanina T., Dascal N.
J. Biol. Chem. 277:3419-3423(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-180 (ISOFORM 34), FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH CACNB2. - Ref.17"Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel."
Tang S., Mikala G., Bahinski A., Yatani A., Varadi G., Schwartz A.
J. Biol. Chem. 268:13026-13029(1993) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, ENZYME REGULATION, MUTAGENESIS, CALCIUM-BINDING, SITE. - Ref.18"Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit."
Qin N., Yagel S., Momplaisir M.-L., Codd E.E., D'Andrea M.R.
Mol. Pharmacol. 62:485-496(2002) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH CACNA2D4, IDENTIFICATION IN A COMPLEX WITH CACNB3 AND CACNA2D4, SUBUNIT, FUNCTION, SUBCELLULAR LOCATION. - Ref.21"Structural insights into binding of STAC proteins to voltage-gated calcium channels."
Wong King Yuen S.M., Campiglio M., Tung C.C., Flucher B.E., Van Petegem F.
Proc. Natl. Acad. Sci. U.S.A. 114:E9520-E9528(2017) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH STAC2 AND STAC3. - Ref.22"Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes."
Nystoriak M.A., Nieves-Cintron M., Patriarchi T., Buonarati O.R., Prada M.P., Morotti S., Grandi E., Fernandes J.D., Forbush K., Hofmann F., Sasse K.C., Scott J.D., Ward S.M., Hell J.W., Navedo M.F.
Sci. Signal. 10:0-0(2017) [PubMed] [Europe PMC] [Abstract]Cited for: PHOSPHORYLATION AT SER-1981, FUNCTION. - Ref.23"Alternative Splicing at N Terminus and Domain I Modulates CaV1.2 Inactivation and Surface Expression."
Bartels P., Yu D., Huang H., Hu Z., Herzig S., Soong T.W.
Biophys. J. 114:2095-2106(2018) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, ENZYME REGULATION, ALTERNATIVE SPLICING, INTERACTION WITH CALM1; CACNA2D1; CACNB2 AND CACNB3, SUBUNIT, SUBCELLULAR LOCATION. - Ref.25"Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex."
Van Petegem F., Chatelain F.C., Minor D.L. Jr.
Nat. Struct. Mol. Biol. 12:1108-1115(2005) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1659-1692, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CALM1, MUTAGENESIS OF 1666-PHE--PHE-1670 AND ILE-1672. - Ref.28"Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization."
Kim E.Y., Rumpf C.H., Van Petegem F., Arant R.J., Findeisen F., Cooley E.S., Isacoff E.Y., Minor D.L. Jr.
EMBO J. 29:3924-3938(2010) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 1609-1685 IN COMPLEX WITH CALM1, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH CACNB2 AND CACNA2D1, MUTAGENESIS OF LEU-1610. - Ref.30"Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism."
Splawski I., Timothy K.W., Sharpe L.M., Decher N., Kumar P., Bloise R., Napolitano C., Schwartz P.J., Joseph R.M., Condouris K., Tager-Flusberg H., Priori S.G., Sanguinetti M.C., Keating M.T.
Cell 119:19-31(2004) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT TS ARG-406, CHARACTERIZATION OF VARIANT TS ARG-406, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. - Ref.31"Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations."
Splawski I., Timothy K.W., Decher N., Kumar P., Sachse F.B., Beggs A.H., Sanguinetti M.C., Keating M.T.
Proc. Natl. Acad. Sci. U.S.A. 102:8089-8096(2005) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT TS SER-402, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2 AND CACNA2D1, SUBUNIT. - Ref.32"Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death."
Antzelevitch C., Pollevick G.D., Cordeiro J.M., Casis O., Sanguinetti M.C., Aizawa Y., Guerchicoff A., Pfeiffer R., Oliva A., Wollnik B., Gelber P., Bonaros E.P. Jr., Burashnikov E., Wu Y., Sargent J.D., Schickel S., Oberheiden R., Bhatia A. , Hsu L.F., Haissaguerre M., Schimpf R., Borggrefe M., Wolpert C.
Circulation 115:442-449(2007) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS BRGDA3 VAL-39 AND ARG-490, CHARACTERIZATION OF VARIANTS BRGDA3 VAL-39 AND ARG-490, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2, SUBUNIT. - Ref.34"Long QT syndrome type 8: novel CACNA1C mutations causing QT prolongation and variant phenotypes."
Fukuyama M., Wang Q., Kato K., Ohno S., Ding W.G., Toyoda F., Itoh H., Kimura H., Makiyama T., Ito M., Matsuura H., Horie M.
Europace 16:1828-1837(2014) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS TS SER-381; ILE-456; ASP-582; HIS-858 AND CYS-1831, CHARACTERIZATION OF VARIANTS TS SER-381; ILE-456; ASP-582; HIS-858 AND CYS-1831, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2 AND CACNA2D1. - Ref.35"Identification and functional characterization of a novel CACNA1C-mediated cardiac disorder characterized by prolonged QT intervals with hypertrophic cardiomyopathy, congenital heart defects, and sudden cardiac death."
Boczek N.J., Ye D., Jin F., Tester D.J., Huseby A., Bos J.M., Johnson A.J., Kanter R., Ackerman M.J.
Circ. Arrhythm. Electrophysiol. 8:1122-1132(2015) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS TS CYS-518 AND HIS-518, CHARACTERIZATION OF VARIANTS TS CYS-518 AND HIS-518, FUNCTION, SUBCELLULAR LOCATION. - Ref.39"Molecular and functional characterization of rare CACNA1C variants in sudden unexplained death in the young."
Sutphin B.S., Boczek N.J., Barajas-Martinez H., Hu D., Ye D., Tester D.J., Antzelevitch C., Ackerman M.J.
Congenit. Heart Dis. 11:683-692(2016) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS GLU-850 DEL AND SER-2091, CHARACTERIZATION OF VARIANTS GLU-850 DEL AND SER-2091, FUNCTION, SUBCELLULAR LOCATION.
<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi
Inhibited by dihydropyridines (DHP), such as isradipine (PubMed:8392192, PubMed:7737988, PubMed:9607315, PubMed:8099908). Inhibited by nifedipine (By similarity). Channel activity is regulated by Ca2+ and calmodulin (PubMed:29742403) (Probable). Binding of STAC1, STAC2 or STAC3 to a region that overlaps with the calmodulin binding site inhibits channel inactivation by Ca2+ and calmodulin (PubMed:29078335). Binding of calmodulin or CABP1 at the same regulatory sites results in opposite effects on the channel function (PubMed:15140941, PubMed:15980432). Shear stress and pressure increases calcium channel activity (PubMed:12176756).By similarity
<p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi
1 Publication<p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More...</a></p> Manual assertion inferred by curator fromi
- Ref.25"Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex."
Van Petegem F., Chatelain F.C., Minor D.L. Jr.
Nat. Struct. Mol. Biol. 12:1108-1115(2005) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1659-1692, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CALM1, MUTAGENESIS OF 1666-PHE--PHE-1670 AND ILE-1672.
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.2"Cloning, chromosomal localization, and functional expression of the alpha-1 subunit of the L-type voltage-dependent calcium channel from normal human heart."
Schultz D., Mikala G., Yatani A., Engle D.B., Iles D.E., Segers B., Sinke R.J., Weghuis D.O., Kloeckner U., Wakamori M., Wang J.-J., Melvin D., Varadi G., Schwartz A.
Proc. Natl. Acad. Sci. U.S.A. 90:6228-6232(1993) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 18 AND 28), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1822-1863, FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ARG-84. - Ref.4"Different voltage-dependent inhibition by dihydropyridines of human Ca2+ channel splice variants."
Soldatov N.M., Bouron A., Reuter H.
J. Biol. Chem. 270:10540-10543(1995) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 12; 19 AND 20), ALTERNATIVE SPLICING, FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-954 AND TYR-958. - Ref.7"Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene."
Zuehlke R.D., Bouron A., Soldatov N.M., Reuter H.
FEBS Lett. 427:220-224(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 21; 22 AND 23), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION. - Ref.8"Alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulation."
Lyford G.L., Strege P.R., Shepard A., Ou Y., Ermilov L., Miller S.M., Gibbons S.J., Rae J.L., Szurszewski J.H., Farrugia G.
Am. J. Physiol. 283:C1001-C1008(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH CACNB2, TISSUE SPECIFICITY. - Ref.17"Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel."
Tang S., Mikala G., Bahinski A., Yatani A., Varadi G., Schwartz A.
J. Biol. Chem. 268:13026-13029(1993) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, ENZYME REGULATION, MUTAGENESIS, CALCIUM-BINDING, SITE. - Ref.19"Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels."
Zhou H., Kim S.-A., Kirk E.A., Tippens A.L., Sun H., Haeseleer F., Lee A.
J. Neurosci. 24:4698-4708(2004) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH CABP1. - Ref.20"Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1."
Zhou H., Yu K., McCoy K.L., Lee A.
J. Biol. Chem. 280:29612-29619(2005) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH CABP1. - Ref.21"Structural insights into binding of STAC proteins to voltage-gated calcium channels."
Wong King Yuen S.M., Campiglio M., Tung C.C., Flucher B.E., Van Petegem F.
Proc. Natl. Acad. Sci. U.S.A. 114:E9520-E9528(2017) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH STAC2 AND STAC3. - Ref.23"Alternative Splicing at N Terminus and Domain I Modulates CaV1.2 Inactivation and Surface Expression."
Bartels P., Yu D., Huang H., Hu Z., Herzig S., Soong T.W.
Biophys. J. 114:2095-2106(2018) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, ENZYME REGULATION, ALTERNATIVE SPLICING, INTERACTION WITH CALM1; CACNA2D1; CACNB2 AND CACNB3, SUBUNIT, SUBCELLULAR LOCATION.
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi | 363 | Calcium1 Publication <p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More...</a></p> Manual assertion inferred by curator fromi
| 1 | |
| <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei | 363 | Calcium ion selectivity and permeability1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi | 706 | Calcium1 Publication <p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More...</a></p> Manual assertion inferred by curator fromi
| 1 | |
| <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei | 706 | Calcium ion selectivity and permeabilityBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi | 1135 | Calcium1 Publication <p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More...</a></p> Manual assertion inferred by curator fromi
| 1 | |
| <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei | 1135 | Calcium ion selectivity and permeability1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei | 1464 | Calcium ion selectivity and permeability1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 |
Regions
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi | 1553 – 1564 | By similarityAdd BLAST | 12 |
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- alpha-actinin binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactioni
- calmodulin binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactioni
- high voltage-gated calcium channel activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- metal ion binding Source: UniProtKB-KW
- voltage-gated calcium channel activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- voltage-gated calcium channel activity involved in AV node cell action potential Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi
- calcium ion transmembrane transport Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- calcium ion transmembrane transport via high voltage-gated calcium channel Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- calcium ion transport into cytosol Source: UniProtKB
- calcium-mediated signaling using extracellular calcium source Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementi
- camera-type eye development Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- cardiac conduction Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- cardiac muscle cell action potential involved in contraction Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementi
- embryonic forelimb morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- heart development Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- immune system development Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- membrane depolarization during atrial cardiac muscle cell action potential Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- membrane depolarization during AV node cell action potential Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: UniProtKB
- regulation of heart rate by cardiac conduction Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
- regulation of insulin secretion Source: Reactome
- regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypei
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi
| Molecular function | Calcium channel, Calmodulin-binding, Ion channel, Voltage-gated channel |
| Biological process | Calcium transport, Ion transport, Transport |
| Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactome - a knowledgebase of biological pathways and processes More...Reactomei | R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion R-HSA-419037 NCAM1 interactions R-HSA-422356 Regulation of insulin secretion R-HSA-5576892 Phase 0 - rapid depolarisation R-HSA-5576893 Phase 2 - plateau phase |
SIGNOR Signaling Network Open Resource More...SIGNORi | Q13936 |
Protein family/group databases
Transport Classification Database More...TCDBi | 1.A.1.11.4 the voltage-gated ion channel (vic) superfamily |
<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Voltage-dependent L-type calcium channel subunit alpha-1CAlternative name(s): Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle Voltage-gated calcium channel subunit alpha Cav1.2 |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi | Name:CACNA1C Synonyms:CACH2, CACN2, CACNL1A1, CCHL1A1 |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>Organismi | Homo sapiens (Human) |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 9606 [NCBI] |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi |
|
Organism-specific databases
Eukaryotic Pathogen Database Resources More...EuPathDBi | HostDB:ENSG00000151067.20 |
Human Gene Nomenclature Database More...HGNCi | HGNC:1390 CACNA1C |
Online Mendelian Inheritance in Man (OMIM) More...MIMi | 114205 gene |
neXtProt; the human protein knowledge platform More...neXtProti | NX_Q13936 |
<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
Plasma membrane
- Cell membrane 20 Publications
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.2"Cloning, chromosomal localization, and functional expression of the alpha-1 subunit of the L-type voltage-dependent calcium channel from normal human heart."
Schultz D., Mikala G., Yatani A., Engle D.B., Iles D.E., Segers B., Sinke R.J., Weghuis D.O., Kloeckner U., Wakamori M., Wang J.-J., Melvin D., Varadi G., Schwartz A.
Proc. Natl. Acad. Sci. U.S.A. 90:6228-6232(1993) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 18 AND 28), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1822-1863, FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ARG-84. - Ref.4"Different voltage-dependent inhibition by dihydropyridines of human Ca2+ channel splice variants."
Soldatov N.M., Bouron A., Reuter H.
J. Biol. Chem. 270:10540-10543(1995) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 12; 19 AND 20), ALTERNATIVE SPLICING, FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-954 AND TYR-958. - Ref.5"Properties of three COOH-terminal splice variants of a human cardiac L-type Ca2+-channel alpha1-subunit."
Kloeckner U., Mikala G., Eisfeld J., Iles D.E., Strobeck M., Mershon J.L., Schwartz A., Varadi G.
Am. J. Physiol. 272:H1372-H1381(1997) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 16 AND 17), ALTERNATIVE SPLICING, FUNCTION, SUBCELLULAR LOCATION, VARIANTS ARG-84; VAL-1869 AND ARG-1893. - Ref.6"Molecular structures involved in L-type calcium channel inactivation. Role of the carboxyl-terminal region encoded by exons 40-42 in alpha1C subunit in the kinetics and Ca2+ dependence of inactivation."
Soldatov N.M., Zuelke R.D., Bouron A., Reuter H.
J. Biol. Chem. 272:3560-3566(1997) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 26 AND 27), ALTERNATIVE SPLICING (ISOFORMS 9 AND 10), FUNCTION, SUBCELLULAR LOCATION. - Ref.7"Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene."
Zuehlke R.D., Bouron A., Soldatov N.M., Reuter H.
FEBS Lett. 427:220-224(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 21; 22 AND 23), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION. - Ref.8"Alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulation."
Lyford G.L., Strege P.R., Shepard A., Ou Y., Ermilov L., Miller S.M., Gibbons S.J., Rae J.L., Szurszewski J.H., Farrugia G.
Am. J. Physiol. 283:C1001-C1008(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH CACNB2, TISSUE SPECIFICITY. - Ref.9"Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit."
Tiwari S., Zhang Y., Heller J., Abernethy D.R., Soldatov N.M.
Proc. Natl. Acad. Sci. U.S.A. 103:17024-17029(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 13; 14; 15; 24 AND 25), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. - Ref.13"A novel long N-terminal isoform of human L-type Ca2+ channel is up-regulated by protein kinase C."
Blumenstein Y., Kanevsky N., Sahar G., Barzilai R., Ivanina T., Dascal N.
J. Biol. Chem. 277:3419-3423(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-180 (ISOFORM 34), FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH CACNB2. - Ref.17"Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel."
Tang S., Mikala G., Bahinski A., Yatani A., Varadi G., Schwartz A.
J. Biol. Chem. 268:13026-13029(1993) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, ENZYME REGULATION, MUTAGENESIS, CALCIUM-BINDING, SITE. - Ref.18"Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit."
Qin N., Yagel S., Momplaisir M.-L., Codd E.E., D'Andrea M.R.
Mol. Pharmacol. 62:485-496(2002) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH CACNA2D4, IDENTIFICATION IN A COMPLEX WITH CACNB3 AND CACNA2D4, SUBUNIT, FUNCTION, SUBCELLULAR LOCATION. - Ref.21"Structural insights into binding of STAC proteins to voltage-gated calcium channels."
Wong King Yuen S.M., Campiglio M., Tung C.C., Flucher B.E., Van Petegem F.
Proc. Natl. Acad. Sci. U.S.A. 114:E9520-E9528(2017) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH STAC2 AND STAC3. - Ref.23"Alternative Splicing at N Terminus and Domain I Modulates CaV1.2 Inactivation and Surface Expression."
Bartels P., Yu D., Huang H., Hu Z., Herzig S., Soong T.W.
Biophys. J. 114:2095-2106(2018) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, ENZYME REGULATION, ALTERNATIVE SPLICING, INTERACTION WITH CALM1; CACNA2D1; CACNB2 AND CACNB3, SUBUNIT, SUBCELLULAR LOCATION. - Ref.25"Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex."
Van Petegem F., Chatelain F.C., Minor D.L. Jr.
Nat. Struct. Mol. Biol. 12:1108-1115(2005) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1659-1692, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CALM1, MUTAGENESIS OF 1666-PHE--PHE-1670 AND ILE-1672. - Ref.28"Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization."
Kim E.Y., Rumpf C.H., Van Petegem F., Arant R.J., Findeisen F., Cooley E.S., Isacoff E.Y., Minor D.L. Jr.
EMBO J. 29:3924-3938(2010) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 1609-1685 IN COMPLEX WITH CALM1, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH CACNB2 AND CACNA2D1, MUTAGENESIS OF LEU-1610. - Ref.30"Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism."
Splawski I., Timothy K.W., Sharpe L.M., Decher N., Kumar P., Bloise R., Napolitano C., Schwartz P.J., Joseph R.M., Condouris K., Tager-Flusberg H., Priori S.G., Sanguinetti M.C., Keating M.T.
Cell 119:19-31(2004) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT TS ARG-406, CHARACTERIZATION OF VARIANT TS ARG-406, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. - Ref.31"Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations."
Splawski I., Timothy K.W., Decher N., Kumar P., Sachse F.B., Beggs A.H., Sanguinetti M.C., Keating M.T.
Proc. Natl. Acad. Sci. U.S.A. 102:8089-8096(2005) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT TS SER-402, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2 AND CACNA2D1, SUBUNIT. - Ref.32"Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death."
Antzelevitch C., Pollevick G.D., Cordeiro J.M., Casis O., Sanguinetti M.C., Aizawa Y., Guerchicoff A., Pfeiffer R., Oliva A., Wollnik B., Gelber P., Bonaros E.P. Jr., Burashnikov E., Wu Y., Sargent J.D., Schickel S., Oberheiden R., Bhatia A. , Hsu L.F., Haissaguerre M., Schimpf R., Borggrefe M., Wolpert C.
Circulation 115:442-449(2007) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS BRGDA3 VAL-39 AND ARG-490, CHARACTERIZATION OF VARIANTS BRGDA3 VAL-39 AND ARG-490, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2, SUBUNIT. - Ref.34"Long QT syndrome type 8: novel CACNA1C mutations causing QT prolongation and variant phenotypes."
Fukuyama M., Wang Q., Kato K., Ohno S., Ding W.G., Toyoda F., Itoh H., Kimura H., Makiyama T., Ito M., Matsuura H., Horie M.
Europace 16:1828-1837(2014) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS TS SER-381; ILE-456; ASP-582; HIS-858 AND CYS-1831, CHARACTERIZATION OF VARIANTS TS SER-381; ILE-456; ASP-582; HIS-858 AND CYS-1831, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2 AND CACNA2D1. - Ref.35"Identification and functional characterization of a novel CACNA1C-mediated cardiac disorder characterized by prolonged QT intervals with hypertrophic cardiomyopathy, congenital heart defects, and sudden cardiac death."
Boczek N.J., Ye D., Jin F., Tester D.J., Huseby A., Bos J.M., Johnson A.J., Kanter R., Ackerman M.J.
Circ. Arrhythm. Electrophysiol. 8:1122-1132(2015) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS TS CYS-518 AND HIS-518, CHARACTERIZATION OF VARIANTS TS CYS-518 AND HIS-518, FUNCTION, SUBCELLULAR LOCATION. - Ref.39"Molecular and functional characterization of rare CACNA1C variants in sudden unexplained death in the young."
Sutphin B.S., Boczek N.J., Barajas-Martinez H., Hu D., Ye D., Tester D.J., Antzelevitch C., Ackerman M.J.
Congenit. Heart Dis. 11:683-692(2016) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS GLU-850 DEL AND SER-2091, CHARACTERIZATION OF VARIANTS GLU-850 DEL AND SER-2091, FUNCTION, SUBCELLULAR LOCATION.
- sarcolemma By similarity
<p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi
; Multi-pass membrane protein Curated - postsynaptic density By similarity
<p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi
- Cell membrane 20 Publications
Other locations
- Perikaryon By similarity
<p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi
- dendrite By similarity
<p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi
Note: Colocalizes with ryanodine receptors in distinct clusters at the junctional membrane, where the sarcolemma and the sarcoplasmic reticulum are in close contact. The interaction between RRAD and CACNB2 promotes the expression of CACNA1C at the cell membrane.By similarity- Perikaryon By similarity
<p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- L-type voltage-gated calcium channel complex Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- plasma membrane Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- voltage-gated calcium channel complex Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
Other locations
- cytoplasm Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- integral component of membrane Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- postsynaptic density Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- Z disc Source: BHF-UCL
Topology
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1 – 124 | CytoplasmicCuratedAdd BLAST | 124 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 125 – 143 | Helical; Name=S1 of repeat IBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 19 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 144 – 158 | ExtracellularCuratedAdd BLAST | 15 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 159 – 179 | Helical; Name=S2 of repeat IBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 21 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 180 – 188 | CytoplasmicCurated | 9 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 189 – 209 | Helical; Name=S3 of repeat IBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 21 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 210 – 232 | ExtracellularCuratedAdd BLAST | 23 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 233 – 251 | Helical; Name=S4 of repeat IBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 19 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 252 – 268 | CytoplasmicCuratedAdd BLAST | 17 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 269 – 290 | Helical; Name=S5 of repeat IBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 22 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 291 – 350 | ExtracellularCuratedAdd BLAST | 60 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei | 351 – 372 | Pore-formingBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 22 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 373 – 380 | ExtracellularCurated | 8 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 381 – 401 | Helical; Name=S6 of repeat IBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 21 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 402 – 524 | CytoplasmicCuratedAdd BLAST | 123 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 525 – 543 | Helical; Name=S1 of repeat IIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 19 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 544 – 554 | ExtracellularCuratedAdd BLAST | 11 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 555 – 575 | Helical; Name=S2 of repeat IIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 21 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 576 – 586 | CytoplasmicCuratedAdd BLAST | 11 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 587 – 606 | Helical; Name=S3 of repeat IIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 20 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 607 – 615 | ExtracellularCurated | 9 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 616 – 634 | Helical; Name=S4 of repeat IIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 19 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 635 – 653 | CytoplasmicCuratedAdd BLAST | 19 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 654 – 673 | Helical; Name=S5 of repeat IIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 20 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 674 – 693 | ExtracellularCuratedAdd BLAST | 20 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei | 694 – 715 | Pore-formingBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 22 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 716 – 725 | ExtracellularCurated | 10 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 726 – 745 | Helical; Name=S6 of repeat IIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 20 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 746 – 900 | CytoplasmicCuratedAdd BLAST | 155 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 901 – 919 | Helical; Name=S1 of repeat IIIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 19 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 920 – 931 | ExtracellularCuratedAdd BLAST | 12 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 932 – 952 | Helical; Name=S2 of repeat IIISequence analysisAdd BLAST | 21 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 953 – 987 | CytoplasmicCuratedAdd BLAST | 35 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 988 – 1006 | Helical; Name=S3 of repeat IIIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 19 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1007 – 1013 | ExtracellularCurated | 7 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 1014 – 1032 | Helical; Name=S4 of repeat IIIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 19 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1033 – 1051 | CytoplasmicCuratedAdd BLAST | 19 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 1052 – 1071 | Helical; Name=S5 of repeat IIIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 20 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1072 – 1121 | ExtracellularCuratedAdd BLAST | 50 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei | 1122 – 1142 | Pore-formingBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 21 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1143 – 1159 | ExtracellularCuratedAdd BLAST | 17 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 1160 – 1181 | Helical; Name=S6 of repeat IIIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 22 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1182 – 1239 | CytoplasmicCuratedAdd BLAST | 58 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 1240 – 1261 | Helical; Name=S1 of repeat IVBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 22 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1262 – 1269 | ExtracellularCurated | 8 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 1270 – 1291 | Helical; Name=S2 of repeat IVBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 22 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1292 – 1301 | CytoplasmicCurated | 10 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 1302 – 1321 | Helical; Name=S3 of repeat IVBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 20 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1322 – 1372 | ExtracellularCuratedAdd BLAST | 51 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 1373 – 1391 | Helical; Name=S4 of repeat IVBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 19 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1392 – 1409 | CytoplasmicCuratedAdd BLAST | 18 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 1410 – 1430 | Helical; Name=S5 of repeat IVBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 21 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1431 – 1452 | ExtracellularCuratedAdd BLAST | 22 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei | 1453 – 1471 | Pore-formingBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 19 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1472 – 1499 | ExtracellularCuratedAdd BLAST | 28 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 1500 – 1524 | Helical; Name=S6 of repeat IVBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 25 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1525 – 2221 | CytoplasmicCuratedAdd BLAST | 697 |
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei
Timothy syndrome (TS)6 Publications
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More...</a></p>
Manual assertion based on experiment ini
- Ref.30"Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism."
Splawski I., Timothy K.W., Sharpe L.M., Decher N., Kumar P., Bloise R., Napolitano C., Schwartz P.J., Joseph R.M., Condouris K., Tager-Flusberg H., Priori S.G., Sanguinetti M.C., Keating M.T.
Cell 119:19-31(2004) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT TS ARG-406, CHARACTERIZATION OF VARIANT TS ARG-406, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. - Ref.31"Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations."
Splawski I., Timothy K.W., Decher N., Kumar P., Sachse F.B., Beggs A.H., Sanguinetti M.C., Keating M.T.
Proc. Natl. Acad. Sci. U.S.A. 102:8089-8096(2005) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT TS SER-402, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2 AND CACNA2D1, SUBUNIT. - Ref.34"Long QT syndrome type 8: novel CACNA1C mutations causing QT prolongation and variant phenotypes."
Fukuyama M., Wang Q., Kato K., Ohno S., Ding W.G., Toyoda F., Itoh H., Kimura H., Makiyama T., Ito M., Matsuura H., Horie M.
Europace 16:1828-1837(2014) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS TS SER-381; ILE-456; ASP-582; HIS-858 AND CYS-1831, CHARACTERIZATION OF VARIANTS TS SER-381; ILE-456; ASP-582; HIS-858 AND CYS-1831, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2 AND CACNA2D1. - Ref.35"Identification and functional characterization of a novel CACNA1C-mediated cardiac disorder characterized by prolonged QT intervals with hypertrophic cardiomyopathy, congenital heart defects, and sudden cardiac death."
Boczek N.J., Ye D., Jin F., Tester D.J., Huseby A., Bos J.M., Johnson A.J., Kanter R., Ackerman M.J.
Circ. Arrhythm. Electrophysiol. 8:1122-1132(2015) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS TS CYS-518 AND HIS-518, CHARACTERIZATION OF VARIANTS TS CYS-518 AND HIS-518, FUNCTION, SUBCELLULAR LOCATION. - Ref.36"Novel Timothy syndrome mutation leading to increase in CACNA1C window current."
Boczek N.J., Miller E.M., Ye D., Nesterenko V.V., Tester D.J., Antzelevitch C., Czosek R.J., Ackerman M.J., Ware S.M.
Heart Rhythm 12:211-219(2015) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT TS THR-1186, CHARACTERIZATION OF VARIANT TS THR-1186. - Ref.37"Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome."
Wemhoener K., Friedrich C., Stallmeyer B., Coffey A.J., Grace A., Zumhagen S., Seebohm G., Ortiz-Bonnin B., Rinne S., Sachse F.B., Schulze-Bahr E., Decher N.
J. Mol. Cell. Cardiol. 80:186-195(2015) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS TS THR-28; GLY-860; THR-1186; VAL-1186; MET-1523; LYS-1544; ILE-1800 MET-1953 AND ILE-2097, CHARACTERIZATION OF VARIANTS TS THR-28; GLY-860; THR-1186; VAL-1186; MET-1523 AND LYS-1544, VARIANTS ARG-37; THR-304; LYS-477; SER-817; THR-1365; ILE-1755; GLY-1765; ASN-1787; MET-1835; ALA-1843; LYS-1948; CYS-1972; GLN-2056; ASN-2081; GLY-2122 AND SER-2174.
Ref.30
"Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism."
Splawski I., Timothy K.W., Sharpe L.M., Decher N., Kumar P., Bloise R., Napolitano C., Schwartz P.J., Joseph R.M., Condouris K., Tager-Flusberg H., Priori S.G., Sanguinetti M.C., Keating M.T.
Cell 119:19-31(2004) [PubMed] [Europe PMC] [Abstract]
Splawski I., Timothy K.W., Sharpe L.M., Decher N., Kumar P., Bloise R., Napolitano C., Schwartz P.J., Joseph R.M., Condouris K., Tager-Flusberg H., Priori S.G., Sanguinetti M.C., Keating M.T.
Cell 119:19-31(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT TS ARG-406, CHARACTERIZATION OF VARIANT TS ARG-406, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Ref.31
"Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations."
Splawski I., Timothy K.W., Decher N., Kumar P., Sachse F.B., Beggs A.H., Sanguinetti M.C., Keating M.T.
Proc. Natl. Acad. Sci. U.S.A. 102:8089-8096(2005) [PubMed] [Europe PMC] [Abstract]
Splawski I., Timothy K.W., Decher N., Kumar P., Sachse F.B., Beggs A.H., Sanguinetti M.C., Keating M.T.
Proc. Natl. Acad. Sci. U.S.A. 102:8089-8096(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT TS SER-402, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2 AND CACNA2D1, SUBUNIT.
Ref.34
"Long QT syndrome type 8: novel CACNA1C mutations causing QT prolongation and variant phenotypes."
Fukuyama M., Wang Q., Kato K., Ohno S., Ding W.G., Toyoda F., Itoh H., Kimura H., Makiyama T., Ito M., Matsuura H., Horie M.
Europace 16:1828-1837(2014) [PubMed] [Europe PMC] [Abstract]
Fukuyama M., Wang Q., Kato K., Ohno S., Ding W.G., Toyoda F., Itoh H., Kimura H., Makiyama T., Ito M., Matsuura H., Horie M.
Europace 16:1828-1837(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS TS SER-381; ILE-456; ASP-582; HIS-858 AND CYS-1831, CHARACTERIZATION OF VARIANTS TS SER-381; ILE-456; ASP-582; HIS-858 AND CYS-1831, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2 AND CACNA2D1.
Ref.35
"Identification and functional characterization of a novel CACNA1C-mediated cardiac disorder characterized by prolonged QT intervals with hypertrophic cardiomyopathy, congenital heart defects, and sudden cardiac death."
Boczek N.J., Ye D., Jin F., Tester D.J., Huseby A., Bos J.M., Johnson A.J., Kanter R., Ackerman M.J.
Circ. Arrhythm. Electrophysiol. 8:1122-1132(2015) [PubMed] [Europe PMC] [Abstract]
Boczek N.J., Ye D., Jin F., Tester D.J., Huseby A., Bos J.M., Johnson A.J., Kanter R., Ackerman M.J.
Circ. Arrhythm. Electrophysiol. 8:1122-1132(2015) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS TS CYS-518 AND HIS-518, CHARACTERIZATION OF VARIANTS TS CYS-518 AND HIS-518, FUNCTION, SUBCELLULAR LOCATION.
Ref.36
"Novel Timothy syndrome mutation leading to increase in CACNA1C window current."
Boczek N.J., Miller E.M., Ye D., Nesterenko V.V., Tester D.J., Antzelevitch C., Czosek R.J., Ackerman M.J., Ware S.M.
Heart Rhythm 12:211-219(2015) [PubMed] [Europe PMC] [Abstract]
Boczek N.J., Miller E.M., Ye D., Nesterenko V.V., Tester D.J., Antzelevitch C., Czosek R.J., Ackerman M.J., Ware S.M.
Heart Rhythm 12:211-219(2015) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT TS THR-1186, CHARACTERIZATION OF VARIANT TS THR-1186.
Ref.37
"Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome."
Wemhoener K., Friedrich C., Stallmeyer B., Coffey A.J., Grace A., Zumhagen S., Seebohm G., Ortiz-Bonnin B., Rinne S., Sachse F.B., Schulze-Bahr E., Decher N.
J. Mol. Cell. Cardiol. 80:186-195(2015) [PubMed] [Europe PMC] [Abstract]
Wemhoener K., Friedrich C., Stallmeyer B., Coffey A.J., Grace A., Zumhagen S., Seebohm G., Ortiz-Bonnin B., Rinne S., Sachse F.B., Schulze-Bahr E., Decher N.
J. Mol. Cell. Cardiol. 80:186-195(2015) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS TS THR-28; GLY-860; THR-1186; VAL-1186; MET-1523; LYS-1544; ILE-1800 MET-1953 AND ILE-2097, CHARACTERIZATION OF VARIANTS TS THR-28; GLY-860; THR-1186; VAL-1186; MET-1523 AND LYS-1544, VARIANTS ARG-37; THR-304; LYS-477; SER-817; THR-1365; ILE-1755; GLY-1765; ASN-1787; MET-1835; ALA-1843; LYS-1948; CYS-1972; GLN-2056; ASN-2081; GLY-2122 AND SER-2174.
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDisorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism.
See also OMIM:601005| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075148 | 28 | A → T in TS; only with cardiac manifestation; unknown pathological significance; increased channel activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075151 | 381 | P → S in TS; only with cardiac manifestation; unknown pathological significance; no effect on channel activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026741 | 402 | G → S in TS. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026742 | 406 | G → R in TS; causes a nearly complete loss of voltage-dependent channel inactivation. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075152 | 456 | M → I in TS; only with cardiac manifestation; unknown pathological significance; no effect on channel activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075154 | 518 | R → C in TS; only with cardiac manifestation; decreased current density; associated with slower inactivation; altered localization. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075155 | 518 | R → H in TS; only with cardiac manifestation; decreased current density; associated with slower inactivation. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075156 | 582 | A → D in TS; only with cardiac manifestation; gain of function effect on channel activity; slower inactivation. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075158 | 858 | R → H in TS; only with cardiac manifestation; gain of function effect on channel activity; slower inactivation. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075159 | 860 | R → G in TS; only with cardiac manifestation; gain of function activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072381 | 1186 | I → T in TS; electrophysiological phenotype, characterized by loss of current density and gain-of-function shift in activation leading to increased steady-state current; gain of function activity. 2 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075160 | 1186 | I → V in TS; only with cardiac manifestation; gain of function activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075162 | 1523 | I → M in TS; only with cardiac manifestation; gain of function activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075163 | 1544 | E → K in TS; only with cardiac manifestation; gain of function activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075167 | 1800 | T → I in TS; only with cardiac manifestation; unknown pathological significance. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075168 | 1831 | G → C in TS; only with cardiac manifestation; unknown pathological significance; no effect on channel activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075172 | 1953 | T → M in TS; only with cardiac manifestation; unknown pathological significance. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075176 | 2097 | V → I in TS; only with cardiac manifestation; unknown pathological significance. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 |
Brugada syndrome 3 (BRGDA3)1 Publication
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More...</a></p>
Manual assertion based on experiment ini
- Ref.32"Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death."
Antzelevitch C., Pollevick G.D., Cordeiro J.M., Casis O., Sanguinetti M.C., Aizawa Y., Guerchicoff A., Pfeiffer R., Oliva A., Wollnik B., Gelber P., Bonaros E.P. Jr., Burashnikov E., Wu Y., Sargent J.D., Schickel S., Oberheiden R., Bhatia A. , Hsu L.F., Haissaguerre M., Schimpf R., Borggrefe M., Wolpert C.
Circulation 115:442-449(2007) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS BRGDA3 VAL-39 AND ARG-490, CHARACTERIZATION OF VARIANTS BRGDA3 VAL-39 AND ARG-490, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2, SUBUNIT.
Ref.32
"Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death."
Antzelevitch C., Pollevick G.D., Cordeiro J.M., Casis O., Sanguinetti M.C., Aizawa Y., Guerchicoff A., Pfeiffer R., Oliva A., Wollnik B., Gelber P., Bonaros E.P. Jr., Burashnikov E., Wu Y., Sargent J.D., Schickel S., Oberheiden R., Bhatia A. , Hsu L.F., Haissaguerre M., Schimpf R., Borggrefe M., Wolpert C.
Circulation 115:442-449(2007) [PubMed] [Europe PMC] [Abstract]
Antzelevitch C., Pollevick G.D., Cordeiro J.M., Casis O., Sanguinetti M.C., Aizawa Y., Guerchicoff A., Pfeiffer R., Oliva A., Wollnik B., Gelber P., Bonaros E.P. Jr., Burashnikov E., Wu Y., Sargent J.D., Schickel S., Oberheiden R., Bhatia A. , Hsu L.F., Haissaguerre M., Schimpf R., Borggrefe M., Wolpert C.
Circulation 115:442-449(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS BRGDA3 VAL-39 AND ARG-490, CHARACTERIZATION OF VARIANTS BRGDA3 VAL-39 AND ARG-490, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2, SUBUNIT.
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionA heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.
See also OMIM:611875| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044039 | 39 | A → V in BRGDA3; unknown pathological significance; affects channel activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044040 | 490 | G → R in BRGDA3; unknown pathological significance; affects channel activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 |
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 363 | E → K: Loss of selectivity for divalent over monovalent cations. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 954 | G → F: Affects voltage-dependent inhibition by dihydropyridines; when associated with I-958. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 958 | Y → I: Affects voltage-dependent inhibition by dihydropyridines; when associated with F-954. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 1135 | E → K: Loss of selectivity for divalent over monovalent cations. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 1464 | E → K: Loss of selectivity for divalent over monovalent cations. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 1610 | L → A: Loss of a low-affinity interaction with CALM1. No effect on channel inactivation by Ca(2+) and calmodulin. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 1666 – 1670 | FYATF → AAATA: Mildly decreased channel activity. No effect on channel inactivation. Loss of channel inactivation by Ca(2+) and calmodulin; when associated with A-1672. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 5 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 1672 | I → A: Loss of channel inactivation by Ca(2+) and calmodulin; when associated with 1666-A--A-1670. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 |
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei
Autism, Autism spectrum disorder, Brugada syndrome, Disease mutation, Long QT syndromeOrganism-specific databases
DisGeNET More...DisGeNETi | 775 |
GeneReviews a resource of expert-authored, peer-reviewed disease descriptions. More...GeneReviewsi | CACNA1C |
MalaCards human disease database More...MalaCardsi | CACNA1C |
Online Mendelian Inheritance in Man (OMIM) More...MIMi | 601005 phenotype 611875 phenotype |
Open Targets More...OpenTargetsi | ENSG00000151067 |
Orphanet; a database dedicated to information on rare diseases and orphan drugs More...Orphaneti | 130 Brugada syndrome 65283 Timothy syndrome |
The Pharmacogenetics and Pharmacogenomics Knowledge Base More...PharmGKBi | PA83 |
Chemistry databases
ChEMBL database of bioactive drug-like small molecules More...ChEMBLi | CHEMBL1940 |
Drug and drug target database More...DrugBanki | DB00381 Amlodipine DB01373 Calcium DB00568 Cinnarizine DB04920 Clevidipine DB04855 Dronedarone DB06751 Drotaverine DB00898 Ethanol DB01023 Felodipine DB00308 Ibutilide DB00270 Isradipine DB00653 Magnesium Sulfate DB01388 Mibefradil DB00622 Nicardipine DB01115 Nifedipine DB06712 Nilvadipine DB00393 Nimodipine DB00401 Nisoldipine DB01054 Nitrendipine DB00421 Spironolactone DB00661 Verapamil |
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYi | 529 |
Polymorphism and mutation databases
BioMuta curated single-nucleotide variation and disease association database More...BioMutai | CACNA1C |
Domain mapping of disease mutations (DMDM) More...DMDMi | 308153651 |
<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000053928 | 1 – 2221 | Voltage-dependent L-type calcium channel subunit alpha-1CAdd BLAST | 2221 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi | 153 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
| <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi | 298 ↔ 326 | By similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | ||
| <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi | 316 ↔ 332 | By similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | ||
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi | 328 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 469 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 476 | PhosphothreonineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 808 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 815 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi | 1078 ↔ 1089 | By similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | ||
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi | 1436 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
| <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi | 1479 ↔ 1495 | By similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | ||
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi | 1487 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1535 | Phosphoserine; by PKASequence analysis | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1718 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1739 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1973 | Phosphoserine; by PKASequence analysis | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1981 | Phosphoserine; by PKA1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 |
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi
Phosphorylation by PKA activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA.1 Publication
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.22"Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes."
Nystoriak M.A., Nieves-Cintron M., Patriarchi T., Buonarati O.R., Prada M.P., Morotti S., Grandi E., Fernandes J.D., Forbush K., Hofmann F., Sasse K.C., Scott J.D., Ward S.M., Hell J.W., Navedo M.F.
Sci. Signal. 10:0-0(2017) [PubMed] [Europe PMC] [Abstract]Cited for: PHOSPHORYLATION AT SER-1981, FUNCTION.
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDb, a database of protein abundance averages across all three domains of life More...PaxDbi | Q13936 |
PeptideAtlas More...PeptideAtlasi | Q13936 |
PRoteomics IDEntifications database More...PRIDEi | Q13936 |
ProteomicsDB human proteome resource More...ProteomicsDBi | 59725 59726 [Q13936-10] 59727 [Q13936-11] 59728 [Q13936-12] 59729 [Q13936-13] 59730 [Q13936-14] 59731 [Q13936-15] 59732 [Q13936-16] 59733 [Q13936-17] 59734 [Q13936-18] 59735 [Q13936-19] 59736 [Q13936-2] 59737 [Q13936-20] 59738 [Q13936-21] 59739 [Q13936-22] 59740 [Q13936-23] 59741 [Q13936-24] 59742 [Q13936-25] 59743 [Q13936-26] 59744 [Q13936-27] 59745 [Q13936-28] 59746 [Q13936-29] 59747 [Q13936-3] 59748 [Q13936-30] 59749 [Q13936-31] 59750 [Q13936-32] 59751 [Q13936-33] 59752 [Q13936-34] 59753 [Q13936-35] 59754 [Q13936-4] 59755 [Q13936-5] 59756 [Q13936-6] 59757 [Q13936-7] 59758 [Q13936-8] 59759 [Q13936-9] |
PTM databases
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | Q13936 |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | Q13936 |
<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi
Detected throughout the brain, including hippocampus, cerebellum and amygdala, throughout the heart and vascular system, including ductus arteriosus, in urinary bladder, and in retina and sclera in the eye (PubMed:15454078). Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.4 Publications
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.2"Cloning, chromosomal localization, and functional expression of the alpha-1 subunit of the L-type voltage-dependent calcium channel from normal human heart."
Schultz D., Mikala G., Yatani A., Engle D.B., Iles D.E., Segers B., Sinke R.J., Weghuis D.O., Kloeckner U., Wakamori M., Wang J.-J., Melvin D., Varadi G., Schwartz A.
Proc. Natl. Acad. Sci. U.S.A. 90:6228-6232(1993) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 18 AND 28), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1822-1863, FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ARG-84. - Ref.8"Alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulation."
Lyford G.L., Strege P.R., Shepard A., Ou Y., Ermilov L., Miller S.M., Gibbons S.J., Rae J.L., Szurszewski J.H., Farrugia G.
Am. J. Physiol. 283:C1001-C1008(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH CACNB2, TISSUE SPECIFICITY. - Ref.9"Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit."
Tiwari S., Zhang Y., Heller J., Abernethy D.R., Soldatov N.M.
Proc. Natl. Acad. Sci. U.S.A. 103:17024-17029(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 13; 14; 15; 24 AND 25), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. - Ref.30"Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism."
Splawski I., Timothy K.W., Sharpe L.M., Decher N., Kumar P., Bloise R., Napolitano C., Schwartz P.J., Joseph R.M., Condouris K., Tager-Flusberg H., Priori S.G., Sanguinetti M.C., Keating M.T.
Cell 119:19-31(2004) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT TS ARG-406, CHARACTERIZATION OF VARIANT TS ARG-406, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSG00000151067 |
ExpressionAtlas, Differential and Baseline Expression More...ExpressionAtlasi | Q13936 baseline and differential |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | Q13936 HS |
Organism-specific databases
Human Protein Atlas More...HPAi | CAB079031 HPA039796 |
<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni
<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1C) and ancillary beta, gamma and delta subunits (PubMed:12181424, PubMed:12176756, PubMed:29742403, PubMed:29078335, PubMed:15141227, PubMed:16299511, PubMed:20953164). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains only one of each type of subunit (Probable). CACNA1C channel activity is modulated by ancillary subunits, such as CACNB1, CACNB2, CACNB3, CACNA2D1 and CACNA2D4 (PubMed:11741969, PubMed:12181424, PubMed:29742403, PubMed:17224476). Intereracts with the gamma subunits CACNG4, CACNG6, CACNG7 and CACNG8 (By similarity). Interacts with CACNB1 (By similarity). Interacts with CACNB2 (PubMed:12176756, PubMed:11741969, PubMed:29742403, PubMed:15141227, PubMed:20953164, PubMed:15863612, PubMed:17224476, PubMed:24728418). Identified in a complex with CACNA2D4 and CACNB3 (PubMed:12181424). Interacts with CACNB3 (PubMed:12181424, PubMed:29742403). Interacts with CACNA2D1 (PubMed:29742403, PubMed:20953164, PubMed:15863612, PubMed:24728418). Interacts with CACNA2D4 (PubMed:12181424). Interacts with CALM1 (PubMed:29742403, PubMed:16299511, PubMed:16338416, PubMed:19279214, PubMed:20953164, PubMed:22518098). Interacts (via the N-terminus and the C-terminal C and IQ motifs) with CABP1; this inhibits Ca2+-dependent channel inactivation (PubMed:15140941, PubMed:15980432). The binding via the C motif is calcium independent whereas the binding via IQ requires the presence of calcium and is mutually exclusive with calmodulin binding (PubMed:15140941). The binding to the cytoplasmic N-terminal domain is calcium independent but is essential for the channel modulation. Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner (By similarity). Interacts with CIB1; the interaction increases upon cardiomyocytes hypertrophy (By similarity). Interacts with STAC2 and STAC3; this inhibits channel inactivation (PubMed:29078335).By similarity
<p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi
Curated16 Publications<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.8"Alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulation."
Lyford G.L., Strege P.R., Shepard A., Ou Y., Ermilov L., Miller S.M., Gibbons S.J., Rae J.L., Szurszewski J.H., Farrugia G.
Am. J. Physiol. 283:C1001-C1008(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH CACNB2, TISSUE SPECIFICITY. - Ref.13"A novel long N-terminal isoform of human L-type Ca2+ channel is up-regulated by protein kinase C."
Blumenstein Y., Kanevsky N., Sahar G., Barzilai R., Ivanina T., Dascal N.
J. Biol. Chem. 277:3419-3423(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-180 (ISOFORM 34), FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH CACNB2. - Ref.18"Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit."
Qin N., Yagel S., Momplaisir M.-L., Codd E.E., D'Andrea M.R.
Mol. Pharmacol. 62:485-496(2002) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH CACNA2D4, IDENTIFICATION IN A COMPLEX WITH CACNB3 AND CACNA2D4, SUBUNIT, FUNCTION, SUBCELLULAR LOCATION. - Ref.19"Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels."
Zhou H., Kim S.-A., Kirk E.A., Tippens A.L., Sun H., Haeseleer F., Lee A.
J. Neurosci. 24:4698-4708(2004) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH CABP1. - Ref.20"Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1."
Zhou H., Yu K., McCoy K.L., Lee A.
J. Biol. Chem. 280:29612-29619(2005) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH CABP1. - Ref.21"Structural insights into binding of STAC proteins to voltage-gated calcium channels."
Wong King Yuen S.M., Campiglio M., Tung C.C., Flucher B.E., Van Petegem F.
Proc. Natl. Acad. Sci. U.S.A. 114:E9520-E9528(2017) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH STAC2 AND STAC3. - Ref.23"Alternative Splicing at N Terminus and Domain I Modulates CaV1.2 Inactivation and Surface Expression."
Bartels P., Yu D., Huang H., Hu Z., Herzig S., Soong T.W.
Biophys. J. 114:2095-2106(2018) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, ENZYME REGULATION, ALTERNATIVE SPLICING, INTERACTION WITH CALM1; CACNA2D1; CACNB2 AND CACNB3, SUBUNIT, SUBCELLULAR LOCATION. - Ref.24"Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain."
Van Petegem F., Clark K.A., Chatelain F.C., Minor D.L. Jr.
Nature 429:671-675(2004) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 428-445 IN COMPLEX WITH CACNB2. - Ref.25"Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex."
Van Petegem F., Chatelain F.C., Minor D.L. Jr.
Nat. Struct. Mol. Biol. 12:1108-1115(2005) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1659-1692, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CALM1, MUTAGENESIS OF 1666-PHE--PHE-1670 AND ILE-1672. - Ref.26"Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel."
Fallon J.L., Halling D.B., Hamilton S.L., Quiocho F.A.
Structure 13:1881-1886(2005) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 1665-1685 IN COMPLEX WITH CALM1. - Ref.27"Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins."
Fallon J.L., Baker M.R., Xiong L., Loy R.E., Yang G., Dirksen R.T., Hamilton S.L., Quiocho F.A.
Proc. Natl. Acad. Sci. U.S.A. 106:5135-5140(2009) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 1609-1682 IN COMPLEX WITH CALM1. - Ref.28"Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization."
Kim E.Y., Rumpf C.H., Van Petegem F., Arant R.J., Findeisen F., Cooley E.S., Isacoff E.Y., Minor D.L. Jr.
EMBO J. 29:3924-3938(2010) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 1609-1685 IN COMPLEX WITH CALM1, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH CACNB2 AND CACNA2D1, MUTAGENESIS OF LEU-1610. - Ref.29"Structural basis for the regulation of L-type voltage-gated calcium channels: interactions between the N-terminal cytoplasmic domain and Ca(2+)-calmodulin."
Liu Z., Vogel H.J.
Front. Mol. Neurosci. 5:38-38(2012) [PubMed] [Europe PMC] [Abstract]Cited for: STRUCTURE BY NMR OF 47-68 IN COMPLEX WITH CALMODULIN, INTERACTION WITH CALM1. - Ref.31"Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations."
Splawski I., Timothy K.W., Decher N., Kumar P., Sachse F.B., Beggs A.H., Sanguinetti M.C., Keating M.T.
Proc. Natl. Acad. Sci. U.S.A. 102:8089-8096(2005) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT TS SER-402, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2 AND CACNA2D1, SUBUNIT. - Ref.32"Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death."
Antzelevitch C., Pollevick G.D., Cordeiro J.M., Casis O., Sanguinetti M.C., Aizawa Y., Guerchicoff A., Pfeiffer R., Oliva A., Wollnik B., Gelber P., Bonaros E.P. Jr., Burashnikov E., Wu Y., Sargent J.D., Schickel S., Oberheiden R., Bhatia A. , Hsu L.F., Haissaguerre M., Schimpf R., Borggrefe M., Wolpert C.
Circulation 115:442-449(2007) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS BRGDA3 VAL-39 AND ARG-490, CHARACTERIZATION OF VARIANTS BRGDA3 VAL-39 AND ARG-490, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2, SUBUNIT. - Ref.34"Long QT syndrome type 8: novel CACNA1C mutations causing QT prolongation and variant phenotypes."
Fukuyama M., Wang Q., Kato K., Ohno S., Ding W.G., Toyoda F., Itoh H., Kimura H., Makiyama T., Ito M., Matsuura H., Horie M.
Europace 16:1828-1837(2014) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANTS TS SER-381; ILE-456; ASP-582; HIS-858 AND CYS-1831, CHARACTERIZATION OF VARIANTS TS SER-381; ILE-456; ASP-582; HIS-858 AND CYS-1831, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, INTERACTION WITH CACNB2 AND CACNA2D1.
<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi
| With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CABP1 | Q9NZU7 | 4 | EBI-1038838,EBI-907894 | |
| CABP1 | Q9NZU7-2 | 2 | EBI-15896749,EBI-15896740 | |
| CACNB1 | Q02641-1 | 2 | EBI-1038838,EBI-15707950 | |
| CACNB2 | Q08289-1 | 4 | EBI-1038838,EBI-15707999 | |
| CACNB3 | P54284 | 2 | EBI-1038838,EBI-1184651 | |
| CALM3 | P62158 | 21 | EBI-1038838,EBI-397435 | |
| Calm3 | P62161 | 2 | EBI-1038838,EBI-397530 | From a different organism. |
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- alpha-actinin binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactioni
- calmodulin binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactioni
Protein-protein interaction databases
The Biological General Repository for Interaction Datasets (BioGrid) More...BioGridi | 107229, 16 interactors |
ComplexPortal: manually curated resource of macromolecular complexes More...ComplexPortali | CPX-3195 Cardiac muscle VGCC complex |
Database of interacting proteins More...DIPi | DIP-29589N |
Protein interaction database and analysis system More...IntActi | Q13936, 9 interactors |
Molecular INTeraction database More...MINTi | Q13936 |
STRING: functional protein association networks More...STRINGi | 9606.ENSP00000266376 |
Chemistry databases
BindingDB database of measured binding affinities More...BindingDBi | Q13936 |
<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsHide details| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined helical regions within the protein sequence.<p><a href='/help/helix' target='_top'>More...</a></p>Helixi | 48 – 65 | Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei | 18 | |
| <p>This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined helical regions within the protein sequence.<p><a href='/help/helix' target='_top'>More...</a></p>Helixi | 429 – 443 | Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei | 15 | |
| <p>This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined helical regions within the protein sequence.<p><a href='/help/helix' target='_top'>More...</a></p>Helixi | 1609 – 1651 | Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei | 43 | |
| <p>This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined hydrogen-bonded turns within the protein sequence. These elements correspond to the DSSP secondary structure code ‘T’.<p><a href='/help/turn' target='_top'>More...</a></p>Turni | 1661 – 1663 | Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei | 3 | |
| <p>This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined helical regions within the protein sequence.<p><a href='/help/helix' target='_top'>More...</a></p>Helixi | 1666 – 1680 | Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei | 15 |
3D structure databases
Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase More...ProteinModelPortali | Q13936 |
SWISS-MODEL Repository - a database of annotated 3D protein structure models More...SMRi | Q13936 |
Database of comparative protein structure models More...ModBasei | Search... |
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... |
Miscellaneous databases
Relative evolutionary importance of amino acids within a protein sequence More...EvolutionaryTracei | Q13936 |
<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati | 111 – 408 | IAdd BLAST | 298 | |
| <p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati | 510 – 756 | IIAdd BLAST | 247 | |
| <p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati | 887 – 1189 | IIIAdd BLAST | 303 | |
| <p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati | 1226 – 1527 | IVAdd BLAST | 302 |
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 47 – 68 | Calmodulin-binding1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 22 | |
| <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 428 – 445 | AID/alpha-interaction domain; mediates interaction with the beta subunit1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 18 | |
| <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 829 – 876 | Interaction with STAC21 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 48 | |
| <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 1109 – 1198 | Dihydropyridine bindingBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 90 | |
| <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 1478 – 1546 | Dihydropyridine bindingBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 69 | |
| <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 1492 – 1534 | Phenylalkylamine bindingBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 43 | |
| <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 1659 – 1686 | Important for interaction with STAC1, STAC2 and STAC3By similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 28 | |
| <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 1665 – 1685 | Calmodulin-binding IQ region4 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 21 | |
| <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 1699 – 1718 | Important for localization in at the junctional membraneBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi Add BLAST | 20 |
Motif
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi | 361 – 364 | Selectivity filter of repeat IBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 4 | |
| <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi | 704 – 707 | Selectivity filter of repeat IIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 4 | |
| <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi | 1133 – 1136 | Selectivity filter of repeat IIIBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 4 | |
| <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi | 1462 – 1465 | Selectivity filter of repeat IVBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi | 4 |
Compositional bias
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi | 654 – 660 | Poly-Leu | 7 | |
| <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi | 768 – 774 | Poly-Glu | 7 | |
| <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi | 1167 – 1173 | Poly-Ile | 7 | |
| <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi | 2084 – 2087 | Poly-Gly | 4 |
<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini
Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.Curated
Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel.By similarity
<p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi
<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. [View classification]Curated
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | KOG2301 Eukaryota ENOG410XNP6 LUCA |
Ensembl GeneTree More...GeneTreei | ENSGT00830000128247 |
The HOVERGEN Database of Homologous Vertebrate Genes More...HOVERGENi | HBG050763 |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | Q13936 |
KEGG Orthology (KO) More...KOi | K04850 |
Database for complete collections of gene phylogenies More...PhylomeDBi | Q13936 |
TreeFam database of animal gene trees More...TreeFami | TF312805 |
Family and domain databases
Gene3D Structural and Functional Annotation of Protein Families More...Gene3Di | 1.20.120.350, 6 hits |
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR031688 CAC1F_C IPR031649 GPHH_dom IPR005821 Ion_trans_dom IPR014873 VDCC_a1su_IQ IPR005451 VDCC_L_a1csu IPR005446 VDCC_L_a1su IPR002077 VDCCAlpha1 IPR027359 Volt_channel_dom_sf |
Pfam protein domain database More...Pfami | View protein in Pfam PF08763 Ca_chan_IQ, 1 hit PF16885 CAC1F_C, 2 hits PF16905 GPHH, 1 hit PF00520 Ion_trans, 5 hits |
Protein Motif fingerprint database; a protein domain database More...PRINTSi | PR00167 CACHANNEL PR01630 LVDCCALPHA1 PR01635 LVDCCALPHA1C |
Simple Modular Architecture Research Tool; a protein domain database More...SMARTi | View protein in SMART SM01062 Ca_chan_IQ, 1 hit |
<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (37)i
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
This entry describes 37 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basketAdded to basket
Note: Additional isoforms seem to exist. Exons 8A, 21, 22, 31, 32, 33, 40B, 43A, 41A and 45 are alternatively spliced in a variety of combinations. Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q13936-1) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: HFCC, Fibroblast
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS
1010 1020 1030 1040 1050
LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG
1060 1070 1080 1090 1100
NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE
1110 1120 1130 1140 1150
VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE
1160 1170 1180 1190 1200
DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC
1210 1220 1230 1240 1250
ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL
1260 1270 1280 1290 1300
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKGYFS
1310 1320 1330 1340 1350
DPWNVFDFLI VIGSIIDVIL SETNHYFCDA WNTFDALIVV GSIVDIAITE
1360 1370 1380 1390 1400
VNPAEHTQCS PSMNAEENSR ISITFFRLFR VMRLVKLLSR GEGIRTLLWT
1410 1420 1430 1440 1450
FIKSFQALPY VALLIVMLFF IYAVIGMQVF GKIALNDTTE INRNNNFQTF
1460 1470 1480 1490 1500
PQAVLLLFRC ATGEAWQDIM LACMPGKKCA PESEPSNSTE GETPCGSSFA
1510 1520 1530 1540 1550
VFYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH HLDEFKRIWA
1560 1570 1580 1590 1600
EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVSMNMPLNS
1610 1620 1630 1640 1650
DGTVMFNATL FALVRTALRI KTEGNLEQAN EELRAIIKKI WKRTSMKLLD
1660 1670 1680 1690 1700
QVVPPAGDDE VTVGKFYATF LIQEYFRKFK KRKEQGLVGK PSQRNALSLQ
1710 1720 1730 1740 1750
AGLRTLHDIG PEIRRAISGD LTAEEELDKA MKEAVSAASE DDIFRRAGGL
1760 1770 1780 1790 1800
FGNHVSYYQS DGRSAFPQTF TTQRPLHINK AGSSQGDTES PSHEKLVDST
1810 1820 1830 1840 1850
FTPSSYSSTG SNANINNANN TALGRLPRPA GYPSTVSTVE GHGPPLSPAI
1860 1870 1880 1890 1900
RVQEVAWKLS SNRERHVPMC EDLELRRDSG SAGTQAHCLL LRKANPSRCH
1910 1920 1930 1940 1950
SRESQAAMAG QEETSQDETY EVKMNHDTEA CSEPSLLSTE MLSYQDDENR
1960 1970 1980 1990 2000
QLTLPEEDKR DIRQSPKRGF LRSASLGRRA SFHLECLKRQ KDRGGDISQK
2010 2020 2030 2040 2050
TVLPLHLVHH QALAVAGLSP LLQRSHSPAS FPRPFATPPA TPGSRGWPPQ
2060 2070 2080 2090 2100
PVPTLRLEGV ESSEKLNSSF PSIHCGSWAE TTPGGGGSSA ARRVRPVSLM
2110 2120 2130 2140 2150
VPSQAGAPGR QFHGSASSLV EAVLISEGLG QFAQDPKFIE VTTQELADAC
2160 2170 2180 2190 2200
DMTIEEMESA ADNILSGGAP QSPNGALLPF VNCRDAGQDR AGGEEDAGCV
2210 2220
RARGRPSEEE LQDSRVYVSS L
Length:2,221
Mass (Da):248,977
Last modified:October 5, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i7E755F7AF4C86769
Isoform 2 (identifier: Q13936-2) [UniParc]FASTAAdd to basketAdded to basketShow »
The sequence of this isoform differs from the canonical sequence as follows:
1864-1897: ERHVPMCEDLELRRDSGSAGTQAHCLLLRKANPS → MHCCDMLDGG...PAGCTAPQHA
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS
1010 1020 1030 1040 1050
LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG
1060 1070 1080 1090 1100
NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE
1110 1120 1130 1140 1150
VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE
1160 1170 1180 1190 1200
DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC
1210 1220 1230 1240 1250
ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL
1260 1270 1280 1290 1300
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKGYFS
1310 1320 1330 1340 1350
DPWNVFDFLI VIGSIIDVIL SETNHYFCDA WNTFDALIVV GSIVDIAITE
1360 1370 1380 1390 1400
VNPAEHTQCS PSMNAEENSR ISITFFRLFR VMRLVKLLSR GEGIRTLLWT
1410 1420 1430 1440 1450
FIKSFQALPY VALLIVMLFF IYAVIGMQVF GKIALNDTTE INRNNNFQTF
1460 1470 1480 1490 1500
PQAVLLLFRC ATGEAWQDIM LACMPGKKCA PESEPSNSTE GETPCGSSFA
1510 1520 1530 1540 1550
VFYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH HLDEFKRIWA
1560 1570 1580 1590 1600
EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVSMNMPLNS
1610 1620 1630 1640 1650
DGTVMFNATL FALVRTALRI KTEGNLEQAN EELRAIIKKI WKRTSMKLLD
1660 1670 1680 1690 1700
QVVPPAGDDE VTVGKFYATF LIQEYFRKFK KRKEQGLVGK PSQRNALSLQ
1710 1720 1730 1740 1750
AGLRTLHDIG PEIRRAISGD LTAEEELDKA MKEAVSAASE DDIFRRAGGL
1760 1770 1780 1790 1800
FGNHVSYYQS DGRSAFPQTF TTQRPLHINK AGSSQGDTES PSHEKLVDST
1810 1820 1830 1840 1850
FTPSSYSSTG SNANINNANN TALGRLPRPA GYPSTVSTVE GHGPPLSPAI
1860 1870 1880 1890 1900
RVQEVAWKLS SNRMHCCDML DGGTFPPALG PRRAPPCLHQ QLQGSLAGLR
1910 1920 1930 1940 1950
EDTPCIVPGH ASLCCSSRVG EWLPAGCTAP QHARCHSRES QAAMAGQEET
1960 1970 1980 1990 2000
SQDETYEVKM NHDTEACSEP SLLSTEMLSY QDDENRQLTL PEEDKRDIRQ
2010 2020 2030 2040 2050
SPKRGFLRSA SLGRRASFHL ECLKRQKDRG GDISQKTVLP LHLVHHQALA
2060 2070 2080 2090 2100
VAGLSPLLQR SHSPASFPRP FATPPATPGS RGWPPQPVPT LRLEGVESSE
2110 2120 2130 2140 2150
KLNSSFPSIH CGSWAETTPG GGGSSAARRV RPVSLMVPSQ AGAPGRQFHG
2160 2170 2180 2190 2200
SASSLVEAVL ISEGLGQFAQ DPKFIEVTTQ ELADACDMTI EEMESAADNI
2210 2220 2230 2240 2250
LSGGAPQSPN GALLPFVNCR DAGQDRAGGE EDAGCVRARG RPSEEELQDS
RVYVSSL
Length:2,257
Mass (Da):252,507
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iDF66240B243CFD41
Isoform 3 (identifier: Q13936-3) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
372-391: VNDAVGRDWPWIYFVTLIII → MQDAMGYELPWVYFVSLVIF
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI FGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS
1010 1020 1030 1040 1050
LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG
1060 1070 1080 1090 1100
NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE
1110 1120 1130 1140 1150
VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE
1160 1170 1180 1190 1200
DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC
1210 1220 1230 1240 1250
ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL
1260 1270 1280 1290 1300
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKGYFS
1310 1320 1330 1340 1350
DPWNVFDFLI VIGSIIDVIL SETNHYFCDA WNTFDALIVV GSIVDIAITE
1360 1370 1380 1390 1400
VNPAEHTQCS PSMNAEENSR ISITFFRLFR VMRLVKLLSR GEGIRTLLWT
1410 1420 1430 1440 1450
FIKSFQALPY VALLIVMLFF IYAVIGMQVF GKIALNDTTE INRNNNFQTF
1460 1470 1480 1490 1500
PQAVLLLFRC ATGEAWQDIM LACMPGKKCA PESEPSNSTE GETPCGSSFA
1510 1520 1530 1540 1550
VFYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH HLDEFKRIWA
1560 1570 1580 1590 1600
EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVSMNMPLNS
1610 1620 1630 1640 1650
DGTVMFNATL FALVRTALRI KTEGNLEQAN EELRAIIKKI WKRTSMKLLD
1660 1670 1680 1690 1700
QVVPPAGDDE VTVGKFYATF LIQEYFRKFK KRKEQGLVGK PSQRNALSLQ
1710 1720 1730 1740 1750
AGLRTLHDIG PEIRRAISGD LTAEEELDKA MKEAVSAASE DDIFRRAGGL
1760 1770 1780 1790 1800
FGNHVSYYQS DGRSAFPQTF TTQRPLHINK AGSSQGDTES PSHEKLVDST
1810 1820 1830 1840 1850
FTPSSYSSTG SNANINNANN TALGRLPRPA GYPSTVSTVE GHGPPLSPAI
1860 1870 1880 1890 1900
RVQEVAWKLS SNRERHVPMC EDLELRRDSG SAGTQAHCLL LRKANPSRCH
1910 1920 1930 1940 1950
SRESQAAMAG QEETSQDETY EVKMNHDTEA CSEPSLLSTE MLSYQDDENR
1960 1970 1980 1990 2000
QLTLPEEDKR DIRQSPKRGF LRSASLGRRA SFHLECLKRQ KDRGGDISQK
2010 2020 2030 2040 2050
TVLPLHLVHH QALAVAGLSP LLQRSHSPAS FPRPFATPPA TPGSRGWPPQ
2060 2070 2080 2090 2100
PVPTLRLEGV ESSEKLNSSF PSIHCGSWAE TTPGGGGSSA ARRVRPVSLM
2110 2120 2130 2140 2150
VPSQAGAPGR QFHGSASSLV EAVLISEGLG QFAQDPKFIE VTTQELADAC
2160 2170 2180 2190 2200
DMTIEEMESA ADNILSGGAP QSPNGALLPF VNCRDAGQDR AGGEEDAGCV
2210 2220
RARGRPSEEE LQDSRVYVSS L
Note: Contains exon 8a.
Show »Length:2,221
Mass (Da):248,995
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iBE971E1A74A4F9AF
Isoform 4 (identifier: Q13936-4) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
932-951: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL
1310 1320 1330 1340 1350
SETNHYFCDA WNTFDALIVV GSIVDIAITE VNPAEHTQCS PSMNAEENSR
1360 1370 1380 1390 1400
ISITFFRLFR VMRLVKLLSR GEGIRTLLWT FIKSFQALPY VALLIVMLFF
1410 1420 1430 1440 1450
IYAVIGMQVF GKIALNDTTE INRNNNFQTF PQAVLLLFRC ATGEAWQDIM
1460 1470 1480 1490 1500
LACMPGKKCA PESEPSNSTE GETPCGSSFA VFYFISFYML CAFLIINLFV
1510 1520 1530 1540 1550
AVIMDNFDYL TRDWSILGPH HLDEFKRIWA EYDPEAKGRI KHLDVVTLLR
1560 1570 1580 1590 1600
RIQPPLGFGK LCPHRVACKR LVSMNMPLNS DGTVMFNATL FALVRTALRI
1610 1620 1630 1640 1650
KTEGNLEQAN EELRAIIKKI WKRTSMKLLD QVVPPAGDDE VTVGKFYATF
1660 1670 1680 1690 1700
LIQEYFRKFK KRKEQGLVGK PSQRNALSLQ AGLRTLHDIG PEIRRAISGD
1710 1720 1730 1740 1750
LTAEEELDKA MKEAVSAASE DDIFRRAGGL FGNHVSYYQS DGRSAFPQTF
1760 1770 1780 1790 1800
TTQRPLHINK AGSSQGDTES PSHEKLVDST FTPSSYSSTG SNANINNANN
1810 1820 1830 1840 1850
TALGRLPRPA GYPSTVSTVE GHGPPLSPAI RVQEVAWKLS SNRERHVPMC
1860 1870 1880 1890 1900
EDLELRRDSG SAGTQAHCLL LRKANPSRCH SRESQAAMAG QEETSQDETY
1910 1920 1930 1940 1950
EVKMNHDTEA CSEPSLLSTE MLSYQDDENR QLTLPEEDKR DIRQSPKRGF
1960 1970 1980 1990 2000
LRSASLGRRA SFHLECLKRQ KDRGGDISQK TVLPLHLVHH QALAVAGLSP
2010 2020 2030 2040 2050
LLQRSHSPAS FPRPFATPPA TPGSRGWPPQ PVPTLRLEGV ESSEKLNSSF
2060 2070 2080 2090 2100
PSIHCGSWAE TTPGGGGSSA ARRVRPVSLM VPSQAGAPGR QFHGSASSLV
2110 2120 2130 2140 2150
EAVLISEGLG QFAQDPKFIE VTTQELADAC DMTIEEMESA ADNILSGGAP
2160 2170 2180 2190 2200
QSPNGALLPF VNCRDAGQDR AGGEEDAGCV RARGRPSEEE LQDSRVYVSS
L
Note: Lacks exon 21.
Show »Length:2,201
Mass (Da):246,587
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iE930E8FDB611A310
Isoform 5 (identifier: Q13936-5) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
952-971: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL
1310 1320 1330 1340 1350
SETNHYFCDA WNTFDALIVV GSIVDIAITE VNPAEHTQCS PSMNAEENSR
1360 1370 1380 1390 1400
ISITFFRLFR VMRLVKLLSR GEGIRTLLWT FIKSFQALPY VALLIVMLFF
1410 1420 1430 1440 1450
IYAVIGMQVF GKIALNDTTE INRNNNFQTF PQAVLLLFRC ATGEAWQDIM
1460 1470 1480 1490 1500
LACMPGKKCA PESEPSNSTE GETPCGSSFA VFYFISFYML CAFLIINLFV
1510 1520 1530 1540 1550
AVIMDNFDYL TRDWSILGPH HLDEFKRIWA EYDPEAKGRI KHLDVVTLLR
1560 1570 1580 1590 1600
RIQPPLGFGK LCPHRVACKR LVSMNMPLNS DGTVMFNATL FALVRTALRI
1610 1620 1630 1640 1650
KTEGNLEQAN EELRAIIKKI WKRTSMKLLD QVVPPAGDDE VTVGKFYATF
1660 1670 1680 1690 1700
LIQEYFRKFK KRKEQGLVGK PSQRNALSLQ AGLRTLHDIG PEIRRAISGD
1710 1720 1730 1740 1750
LTAEEELDKA MKEAVSAASE DDIFRRAGGL FGNHVSYYQS DGRSAFPQTF
1760 1770 1780 1790 1800
TTQRPLHINK AGSSQGDTES PSHEKLVDST FTPSSYSSTG SNANINNANN
1810 1820 1830 1840 1850
TALGRLPRPA GYPSTVSTVE GHGPPLSPAI RVQEVAWKLS SNRERHVPMC
1860 1870 1880 1890 1900
EDLELRRDSG SAGTQAHCLL LRKANPSRCH SRESQAAMAG QEETSQDETY
1910 1920 1930 1940 1950
EVKMNHDTEA CSEPSLLSTE MLSYQDDENR QLTLPEEDKR DIRQSPKRGF
1960 1970 1980 1990 2000
LRSASLGRRA SFHLECLKRQ KDRGGDISQK TVLPLHLVHH QALAVAGLSP
2010 2020 2030 2040 2050
LLQRSHSPAS FPRPFATPPA TPGSRGWPPQ PVPTLRLEGV ESSEKLNSSF
2060 2070 2080 2090 2100
PSIHCGSWAE TTPGGGGSSA ARRVRPVSLM VPSQAGAPGR QFHGSASSLV
2110 2120 2130 2140 2150
EAVLISEGLG QFAQDPKFIE VTTQELADAC DMTIEEMESA ADNILSGGAP
2160 2170 2180 2190 2200
QSPNGALLPF VNCRDAGQDR AGGEEDAGCV RARGRPSEEE LQDSRVYVSS
L
Note: Lacks exon 22.
Show »Length:2,201
Mass (Da):246,724
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i491524D070A5EF23
Isoform 6 (identifier: Q13936-6) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
1297-1324: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS
1010 1020 1030 1040 1050
LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG
1060 1070 1080 1090 1100
NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE
1110 1120 1130 1140 1150
VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE
1160 1170 1180 1190 1200
DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC
1210 1220 1230 1240 1250
ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL
1260 1270 1280 1290 1300
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKHYFC
1310 1320 1330 1340 1350
DAWNTFDALI VVGSIVDIAI TEVNPAEHTQ CSPSMNAEEN SRISITFFRL
1360 1370 1380 1390 1400
FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIVML FFIYAVIGMQ
1410 1420 1430 1440 1450
VFGKIALNDT TEINRNNNFQ TFPQAVLLLF RCATGEAWQD IMLACMPGKK
1460 1470 1480 1490 1500
CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL FVAVIMDNFD
1510 1520 1530 1540 1550
YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF
1560 1570 1580 1590 1600
GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ
1610 1620 1630 1640 1650
ANEELRAIIK KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK
1660 1670 1680 1690 1700
FKKRKEQGLV GKPSQRNALS LQAGLRTLHD IGPEIRRAIS GDLTAEEELD
1710 1720 1730 1740 1750
KAMKEAVSAA SEDDIFRRAG GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI
1760 1770 1780 1790 1800
NKAGSSQGDT ESPSHEKLVD STFTPSSYSS TGSNANINNA NNTALGRLPR
1810 1820 1830 1840 1850
PAGYPSTVST VEGHGPPLSP AIRVQEVAWK LSSNRERHVP MCEDLELRRD
1860 1870 1880 1890 1900
SGSAGTQAHC LLLRKANPSR CHSRESQAAM AGQEETSQDE TYEVKMNHDT
1910 1920 1930 1940 1950
EACSEPSLLS TEMLSYQDDE NRQLTLPEED KRDIRQSPKR GFLRSASLGR
1960 1970 1980 1990 2000
RASFHLECLK RQKDRGGDIS QKTVLPLHLV HHQALAVAGL SPLLQRSHSP
2010 2020 2030 2040 2050
ASFPRPFATP PATPGSRGWP PQPVPTLRLE GVESSEKLNS SFPSIHCGSW
2060 2070 2080 2090 2100
AETTPGGGGS SAARRVRPVS LMVPSQAGAP GRQFHGSASS LVEAVLISEG
2110 2120 2130 2140 2150
LGQFAQDPKF IEVTTQELAD ACDMTIEEME SAADNILSGG APQSPNGALL
2160 2170 2180 2190
PFVNCRDAGQ DRAGGEEDAG CVRARGRPSE EELQDSRVYV SSL
Note: Lacks exon 31.
Show »Length:2,193
Mass (Da):245,820
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i7661E18AB73EB11D
Isoform 7 (identifier: Q13936-7) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
1325-1352: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS
1010 1020 1030 1040 1050
LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG
1060 1070 1080 1090 1100
NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE
1110 1120 1130 1140 1150
VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE
1160 1170 1180 1190 1200
DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC
1210 1220 1230 1240 1250
ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL
1260 1270 1280 1290 1300
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKGYFS
1310 1320 1330 1340 1350
DPWNVFDFLI VIGSIIDVIL SETNPAEHTQ CSPSMNAEEN SRISITFFRL
1360 1370 1380 1390 1400
FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIVML FFIYAVIGMQ
1410 1420 1430 1440 1450
VFGKIALNDT TEINRNNNFQ TFPQAVLLLF RCATGEAWQD IMLACMPGKK
1460 1470 1480 1490 1500
CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL FVAVIMDNFD
1510 1520 1530 1540 1550
YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF
1560 1570 1580 1590 1600
GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ
1610 1620 1630 1640 1650
ANEELRAIIK KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK
1660 1670 1680 1690 1700
FKKRKEQGLV GKPSQRNALS LQAGLRTLHD IGPEIRRAIS GDLTAEEELD
1710 1720 1730 1740 1750
KAMKEAVSAA SEDDIFRRAG GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI
1760 1770 1780 1790 1800
NKAGSSQGDT ESPSHEKLVD STFTPSSYSS TGSNANINNA NNTALGRLPR
1810 1820 1830 1840 1850
PAGYPSTVST VEGHGPPLSP AIRVQEVAWK LSSNRERHVP MCEDLELRRD
1860 1870 1880 1890 1900
SGSAGTQAHC LLLRKANPSR CHSRESQAAM AGQEETSQDE TYEVKMNHDT
1910 1920 1930 1940 1950
EACSEPSLLS TEMLSYQDDE NRQLTLPEED KRDIRQSPKR GFLRSASLGR
1960 1970 1980 1990 2000
RASFHLECLK RQKDRGGDIS QKTVLPLHLV HHQALAVAGL SPLLQRSHSP
2010 2020 2030 2040 2050
ASFPRPFATP PATPGSRGWP PQPVPTLRLE GVESSEKLNS SFPSIHCGSW
2060 2070 2080 2090 2100
AETTPGGGGS SAARRVRPVS LMVPSQAGAP GRQFHGSASS LVEAVLISEG
2110 2120 2130 2140 2150
LGQFAQDPKF IEVTTQELAD ACDMTIEEME SAADNILSGG APQSPNGALL
2160 2170 2180 2190
PFVNCRDAGQ DRAGGEEDAG CVRARGRPSE EELQDSRVYV SSL
Note: Lacks exon 32.
Show »Length:2,193
Mass (Da):245,868
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i3E74F4FE1EFDC425
Isoform 8 (identifier: Q13936-8) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
1353-1363: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS
1010 1020 1030 1040 1050
LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG
1060 1070 1080 1090 1100
NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE
1110 1120 1130 1140 1150
VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE
1160 1170 1180 1190 1200
DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC
1210 1220 1230 1240 1250
ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL
1260 1270 1280 1290 1300
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKGYFS
1310 1320 1330 1340 1350
DPWNVFDFLI VIGSIIDVIL SETNHYFCDA WNTFDALIVV GSIVDIAITE
1360 1370 1380 1390 1400
VNNAEENSRI SITFFRLFRV MRLVKLLSRG EGIRTLLWTF IKSFQALPYV
1410 1420 1430 1440 1450
ALLIVMLFFI YAVIGMQVFG KIALNDTTEI NRNNNFQTFP QAVLLLFRCA
1460 1470 1480 1490 1500
TGEAWQDIML ACMPGKKCAP ESEPSNSTEG ETPCGSSFAV FYFISFYMLC
1510 1520 1530 1540 1550
AFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFKRIWAE YDPEAKGRIK
1560 1570 1580 1590 1600
HLDVVTLLRR IQPPLGFGKL CPHRVACKRL VSMNMPLNSD GTVMFNATLF
1610 1620 1630 1640 1650
ALVRTALRIK TEGNLEQANE ELRAIIKKIW KRTSMKLLDQ VVPPAGDDEV
1660 1670 1680 1690 1700
TVGKFYATFL IQEYFRKFKK RKEQGLVGKP SQRNALSLQA GLRTLHDIGP
1710 1720 1730 1740 1750
EIRRAISGDL TAEEELDKAM KEAVSAASED DIFRRAGGLF GNHVSYYQSD
1760 1770 1780 1790 1800
GRSAFPQTFT TQRPLHINKA GSSQGDTESP SHEKLVDSTF TPSSYSSTGS
1810 1820 1830 1840 1850
NANINNANNT ALGRLPRPAG YPSTVSTVEG HGPPLSPAIR VQEVAWKLSS
1860 1870 1880 1890 1900
NRERHVPMCE DLELRRDSGS AGTQAHCLLL RKANPSRCHS RESQAAMAGQ
1910 1920 1930 1940 1950
EETSQDETYE VKMNHDTEAC SEPSLLSTEM LSYQDDENRQ LTLPEEDKRD
1960 1970 1980 1990 2000
IRQSPKRGFL RSASLGRRAS FHLECLKRQK DRGGDISQKT VLPLHLVHHQ
2010 2020 2030 2040 2050
ALAVAGLSPL LQRSHSPASF PRPFATPPAT PGSRGWPPQP VPTLRLEGVE
2060 2070 2080 2090 2100
SSEKLNSSFP SIHCGSWAET TPGGGGSSAA RRVRPVSLMV PSQAGAPGRQ
2110 2120 2130 2140 2150
FHGSASSLVE AVLISEGLGQ FAQDPKFIEV TTQELADACD MTIEEMESAA
2160 2170 2180 2190 2200
DNILSGGAPQ SPNGALLPFV NCRDAGQDRA GGEEDAGCVR ARGRPSEEEL
2210
QDSRVYVSSL
Note: Lacks exon 33.
Show »Length:2,210
Mass (Da):247,807
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iD48DBFDEFBEDF3DC
Isoform 9 (identifier: Q13936-9) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
1618-1699: LRIKTEGNLE...KPSQRNALSL → LREAELSSQV...RGPHHPPLGF
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS
1010 1020 1030 1040 1050
LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG
1060 1070 1080 1090 1100
NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE
1110 1120 1130 1140 1150
VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE
1160 1170 1180 1190 1200
DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC
1210 1220 1230 1240 1250
ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL
1260 1270 1280 1290 1300
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKGYFS
1310 1320 1330 1340 1350
DPWNVFDFLI VIGSIIDVIL SETNHYFCDA WNTFDALIVV GSIVDIAITE
1360 1370 1380 1390 1400
VNPAEHTQCS PSMNAEENSR ISITFFRLFR VMRLVKLLSR GEGIRTLLWT
1410 1420 1430 1440 1450
FIKSFQALPY VALLIVMLFF IYAVIGMQVF GKIALNDTTE INRNNNFQTF
1460 1470 1480 1490 1500
PQAVLLLFRC ATGEAWQDIM LACMPGKKCA PESEPSNSTE GETPCGSSFA
1510 1520 1530 1540 1550
VFYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH HLDEFKRIWA
1560 1570 1580 1590 1600
EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVSMNMPLNS
1610 1620 1630 1640 1650
DGTVMFNATL FALVRTALRE AELSSQVQYQ AKEASLLERR RKSSHPKSST
1660 1670 1680 1690 1700
KPNKLLSSGG STGWVEDARA LEGQVLARGC GWLGSLEERE RGPHHPPLGF
1710 1720 1730 1740 1750
QAGLRTLHDI GPEIRRAISG DLTAEEELDK AMKEAVSAAS EDDIFRRAGG
1760 1770 1780 1790 1800
LFGNHVSYYQ SDGRSAFPQT FTTQRPLHIN KAGSSQGDTE SPSHEKLVDS
1810 1820 1830 1840 1850
TFTPSSYSST GSNANINNAN NTALGRLPRP AGYPSTVSTV EGHGPPLSPA
1860 1870 1880 1890 1900
IRVQEVAWKL SSNRERHVPM CEDLELRRDS GSAGTQAHCL LLRKANPSRC
1910 1920 1930 1940 1950
HSRESQAAMA GQEETSQDET YEVKMNHDTE ACSEPSLLST EMLSYQDDEN
1960 1970 1980 1990 2000
RQLTLPEEDK RDIRQSPKRG FLRSASLGRR ASFHLECLKR QKDRGGDISQ
2010 2020 2030 2040 2050
KTVLPLHLVH HQALAVAGLS PLLQRSHSPA SFPRPFATPP ATPGSRGWPP
2060 2070 2080 2090 2100
QPVPTLRLEG VESSEKLNSS FPSIHCGSWA ETTPGGGGSS AARRVRPVSL
2110 2120 2130 2140 2150
MVPSQAGAPG RQFHGSASSL VEAVLISEGL GQFAQDPKFI EVTTQELADA
2160 2170 2180 2190 2200
CDMTIEEMES AADNILSGGA PQSPNGALLP FVNCRDAGQD RAGGEEDAGC
2210 2220
VRARGRPSEE ELQDSRVYVS SL
Note: Contains exon 40B and 43A.
Show »Length:2,222
Mass (Da):248,607
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iD861F6A49A1E0B80
Isoform 10 (identifier: Q13936-10) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
1623-1623: E → EEGPSPSEAHQGAEDPFRPA
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS
1010 1020 1030 1040 1050
LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG
1060 1070 1080 1090 1100
NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE
1110 1120 1130 1140 1150
VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE
1160 1170 1180 1190 1200
DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC
1210 1220 1230 1240 1250
ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL
1260 1270 1280 1290 1300
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKGYFS
1310 1320 1330 1340 1350
DPWNVFDFLI VIGSIIDVIL SETNHYFCDA WNTFDALIVV GSIVDIAITE
1360 1370 1380 1390 1400
VNPAEHTQCS PSMNAEENSR ISITFFRLFR VMRLVKLLSR GEGIRTLLWT
1410 1420 1430 1440 1450
FIKSFQALPY VALLIVMLFF IYAVIGMQVF GKIALNDTTE INRNNNFQTF
1460 1470 1480 1490 1500
PQAVLLLFRC ATGEAWQDIM LACMPGKKCA PESEPSNSTE GETPCGSSFA
1510 1520 1530 1540 1550
VFYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH HLDEFKRIWA
1560 1570 1580 1590 1600
EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVSMNMPLNS
1610 1620 1630 1640 1650
DGTVMFNATL FALVRTALRI KTEEGPSPSE AHQGAEDPFR PAGNLEQANE
1660 1670 1680 1690 1700
ELRAIIKKIW KRTSMKLLDQ VVPPAGDDEV TVGKFYATFL IQEYFRKFKK
1710 1720 1730 1740 1750
RKEQGLVGKP SQRNALSLQA GLRTLHDIGP EIRRAISGDL TAEEELDKAM
1760 1770 1780 1790 1800
KEAVSAASED DIFRRAGGLF GNHVSYYQSD GRSAFPQTFT TQRPLHINKA
1810 1820 1830 1840 1850
GSSQGDTESP SHEKLVDSTF TPSSYSSTGS NANINNANNT ALGRLPRPAG
1860 1870 1880 1890 1900
YPSTVSTVEG HGPPLSPAIR VQEVAWKLSS NRERHVPMCE DLELRRDSGS
1910 1920 1930 1940 1950
AGTQAHCLLL RKANPSRCHS RESQAAMAGQ EETSQDETYE VKMNHDTEAC
1960 1970 1980 1990 2000
SEPSLLSTEM LSYQDDENRQ LTLPEEDKRD IRQSPKRGFL RSASLGRRAS
2010 2020 2030 2040 2050
FHLECLKRQK DRGGDISQKT VLPLHLVHHQ ALAVAGLSPL LQRSHSPASF
2060 2070 2080 2090 2100
PRPFATPPAT PGSRGWPPQP VPTLRLEGVE SSEKLNSSFP SIHCGSWAET
2110 2120 2130 2140 2150
TPGGGGSSAA RRVRPVSLMV PSQAGAPGRQ FHGSASSLVE AVLISEGLGQ
2160 2170 2180 2190 2200
FAQDPKFIEV TTQELADACD MTIEEMESAA DNILSGGAPQ SPNGALLPFV
2210 2220 2230 2240
NCRDAGQDRA GGEEDAGCVR ARGRPSEEEL QDSRVYVSSL
Note: Contains exon 41A.
Show »Length:2,240
Mass (Da):250,938
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iE8571E4C44FB3786
Isoform 11 (identifier: Q13936-11) [UniParc]FASTAAdd to basketAdded to basket
Also known as: Alpha-1C.90
The sequence of this isoform differs from the canonical sequence as follows:
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS
1010 1020 1030 1040 1050
LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG
1060 1070 1080 1090 1100
NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE
1110 1120 1130 1140 1150
VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE
1160 1170 1180 1190 1200
DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC
1210 1220 1230 1240 1250
ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL
1260 1270 1280 1290 1300
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKGYFS
1310 1320 1330 1340 1350
DPWNVFDFLI VIGSIIDVIL SETNHYFCDA WNTFDALIVV GSIVDIAITE
1360 1370 1380 1390 1400
VNPAEHTQCS PSMNAEENSR ISITFFRLFR VMRLVKLLSR GEGIRTLLWT
1410 1420 1430 1440 1450
FIKSFQALPY VALLIVMLFF IYAVIGMQVF GKIALNDTTE INRNNNFQTF
1460 1470 1480 1490 1500
PQAVLLLFRC ATGEAWQDIM LACMPGKKCA PESEPSNSTE GETPCGSSFA
1510 1520 1530 1540 1550
VFYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH HLDEFKRIWA
1560 1570 1580 1590 1600
EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVSMNMPLNS
1610 1620 1630 1640 1650
DGTVMFNATL FALVRTALRI KTEGNLEQAN EELRAIIKKI WKRTSMKLLD
1660 1670 1680 1690 1700
QVVPPAGDDE VTVGKFYATF LIQEYFRKFK KRKEQGLVGK PSQRNALSLQ
1710 1720 1730 1740 1750
AGLRTLHDIG PEIRRAISGD LTAEEELDKA MKEAVSAASE DDIFRRAGGL
1760 1770 1780 1790 1800
FGNHVSYYQS DGRSAFPQTF TTQRPLHINK AGSSQGDTES PSHEKLVDST
1810 1820 1830 1840 1850
FTPSSYSSTG SNANINNANN TALGRLPRPA GYPSTVSTVE GHGPPLSPAI
1860 1870 1880 1890 1900
RVQEVAWKLS SNRCHSRESQ AAMAGQEETS QDETYEVKMN HDTEACSEPS
1910 1920 1930 1940 1950
LLSTEMLSYQ DDENRQLTLP EEDKRDIRQS PKRGFLRSAS LGRRASFHLE
1960 1970 1980 1990 2000
CLKRQKDRGG DISQKTVLPL HLVHHQALAV AGLSPLLQRS HSPASFPRPF
2010 2020 2030 2040 2050
ATPPATPGSR GWPPQPVPTL RLEGVESSEK LNSSFPSIHC GSWAETTPGG
2060 2070 2080 2090 2100
GGSSAARRVR PVSLMVPSQA GAPGRQFHGS ASSLVEAVLI SEGLGQFAQD
2110 2120 2130 2140 2150
PKFIEVTTQE LADACDMTIE EMESAADNIL SGGAPQSPNG ALLPFVNCRD
2160 2170 2180
AGQDRAGGEE DAGCVRARGR PSEEELQDSR VYVSSL
Note: Lacks exon 45.
Show »Length:2,186
Mass (Da):245,047
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iE8D9E8F0FFDC1A4D
Isoform 12 (identifier: Q13936-12) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.70
The sequence of this isoform differs from the canonical sequence as follows:
952-971: Missing.
1297-1324: Missing.
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TEVNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL
1610 1620 1630 1640 1650
LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS
1660 1670 1680 1690 1700
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG
1710 1720 1730 1740 1750
GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI NKAGSSQGDT ESPSHEKLVD
1760 1770 1780 1790 1800
STFTPSSYSS TGSNANINNA NNTALGRLPR PAGYPSTVST VEGHGPPLSP
1810 1820 1830 1840 1850
AIRVQEVAWK LSSNRCHSRE SQAAMAGQEE TSQDETYEVK MNHDTEACSE
1860 1870 1880 1890 1900
PSLLSTEMLS YQDDENRQLT LPEEDKRDIR QSPKRGFLRS ASLGRRASFH
1910 1920 1930 1940 1950
LECLKRQKDR GGDISQKTVL PLHLVHHQAL AVAGLSPLLQ RSHSPASFPR
1960 1970 1980 1990 2000
PFATPPATPG SRGWPPQPVP TLRLEGVESS EKLNSSFPSI HCGSWAETTP
2010 2020 2030 2040 2050
GGGGSSAARR VRPVSLMVPS QAGAPGRQFH GSASSLVEAV LISEGLGQFA
2060 2070 2080 2090 2100
QDPKFIEVTT QELADACDMT IEEMESAADN ILSGGAPQSP NGALLPFVNC
2110 2120 2130
RDAGQDRAGG EEDAGCVRAR GRPSEEELQD SRVYVSSL
Length:2,138
Mass (Da):239,638
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i200DA905F439D369
Isoform 13 (identifier: Q13936-13) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.127
The sequence of this isoform differs from the canonical sequence as follows:
952-971: Missing.
1325-1352: Missing.
1623-1623: E → EEGPSPSEAHQGAEDPFRPA
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL
1310 1320 1330 1340 1350
SETNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEEGPSP SEAHQGAEDP FRPAGNLEQA
1610 1620 1630 1640 1650
NEELRAIIKK IWKRTSMKLL DQVVPPAGDD EVTVGKFYAT FLIQEYFRKF
1660 1670 1680 1690 1700
KKRKEQGLVG KPSQRNALSL QAGLRTLHDI GPEIRRAISG DLTAEEELDK
1710 1720 1730 1740 1750
AMKEAVSAAS EDDIFRRAGG LFGNHVSYYQ SDGRSAFPQT FTTQRPLHIN
1760 1770 1780 1790 1800
KAGSSQGDTE SPSHEKLVDS TFTPSSYSST GSNANINNAN NTALGRLPRP
1810 1820 1830 1840 1850
AGYPSTVSTV EGHGPPLSPA IRVQEVAWKL SSNRCHSRES QAAMAGQEET
1860 1870 1880 1890 1900
SQDETYEVKM NHDTEACSEP SLLSTEMLSY QDDENRQLTL PEEDKRDIRQ
1910 1920 1930 1940 1950
SPKRGFLRSA SLGRRASFHL ECLKRQKDRG GDISQKTVLP LHLVHHQALA
1960 1970 1980 1990 2000
VAGLSPLLQR SHSPASFPRP FATPPATPGS RGWPPQPVPT LRLEGVESSE
2010 2020 2030 2040 2050
KLNSSFPSIH CGSWAETTPG GGGSSAARRV RPVSLMVPSQ AGAPGRQFHG
2060 2070 2080 2090 2100
SASSLVEAVL ISEGLGQFAQ DPKFIEVTTQ ELADACDMTI EEMESAADNI
2110 2120 2130 2140 2150
LSGGAPQSPN GALLPFVNCR DAGQDRAGGE EDAGCVRARG RPSEEELQDS
RVYVSSL
Length:2,157
Mass (Da):241,647
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i1153EEBBE8CE80B3
Isoform 14 (identifier: Q13936-14) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.126
The sequence of this isoform differs from the canonical sequence as follows:
952-971: Missing.
1297-1324: Missing.
1363-1363: M → MGPSCSHPPLAVLTAPPVADGFQ
1623-1623: E → EEGPSPSEAHQGAEDPFRPA
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TEVNPAEHTQ CSPSMGPSCS HPPLAVLTAP PVADGFQNAE ENSRISITFF
1360 1370 1380 1390 1400
RLFRVMRLVK LLSRGEGIRT LLWTFIKSFQ ALPYVALLIV MLFFIYAVIG
1410 1420 1430 1440 1450
MQVFGKIALN DTTEINRNNN FQTFPQAVLL LFRCATGEAW QDIMLACMPG
1460 1470 1480 1490 1500
KKCAPESEPS NSTEGETPCG SSFAVFYFIS FYMLCAFLII NLFVAVIMDN
1510 1520 1530 1540 1550
FDYLTRDWSI LGPHHLDEFK RIWAEYDPEA KGRIKHLDVV TLLRRIQPPL
1560 1570 1580 1590 1600
GFGKLCPHRV ACKRLVSMNM PLNSDGTVMF NATLFALVRT ALRIKTEEGP
1610 1620 1630 1640 1650
SPSEAHQGAE DPFRPAGNLE QANEELRAII KKIWKRTSMK LLDQVVPPAG
1660 1670 1680 1690 1700
DDEVTVGKFY ATFLIQEYFR KFKKRKEQGL VGKPSQRNAL SLQAGLRTLH
1710 1720 1730 1740 1750
DIGPEIRRAI SGDLTAEEEL DKAMKEAVSA ASEDDIFRRA GGLFGNHVSY
1760 1770 1780 1790 1800
YQSDGRSAFP QTFTTQRPLH INKAGSSQGD TESPSHEKLV DSTFTPSSYS
1810 1820 1830 1840 1850
STGSNANINN ANNTALGRLP RPAGYPSTVS TVEGHGPPLS PAIRVQEVAW
1860 1870 1880 1890 1900
KLSSNRCHSR ESQAAMAGQE ETSQDETYEV KMNHDTEACS EPSLLSTEML
1910 1920 1930 1940 1950
SYQDDENRQL TLPEEDKRDI RQSPKRGFLR SASLGRRASF HLECLKRQKD
1960 1970 1980 1990 2000
RGGDISQKTV LPLHLVHHQA LAVAGLSPLL QRSHSPASFP RPFATPPATP
2010 2020 2030 2040 2050
GSRGWPPQPV PTLRLEGVES SEKLNSSFPS IHCGSWAETT PGGGGSSAAR
2060 2070 2080 2090 2100
RVRPVSLMVP SQAGAPGRQF HGSASSLVEA VLISEGLGQF AQDPKFIEVT
2110 2120 2130 2140 2150
TQELADACDM TIEEMESAAD NILSGGAPQS PNGALLPFVN CRDAGQDRAG
2160 2170
GEEDAGCVRA RGRPSEEELQ DSRVYVSSL
Length:2,179
Mass (Da):243,742
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i3826188216441CBC
Isoform 15 (identifier: Q13936-15) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.125
The sequence of this isoform differs from the canonical sequence as follows:
952-971: Missing.
1297-1324: Missing.
1351-1363: Missing.
1623-1623: E → EEGPSPSEAHQGAEDPFRPA
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TENAEENSRI SITFFRLFRV MRLVKLLSRG EGIRTLLWTF IKSFQALPYV
1360 1370 1380 1390 1400
ALLIVMLFFI YAVIGMQVFG KIALNDTTEI NRNNNFQTFP QAVLLLFRCA
1410 1420 1430 1440 1450
TGEAWQDIML ACMPGKKCAP ESEPSNSTEG ETPCGSSFAV FYFISFYMLC
1460 1470 1480 1490 1500
AFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFKRIWAE YDPEAKGRIK
1510 1520 1530 1540 1550
HLDVVTLLRR IQPPLGFGKL CPHRVACKRL VSMNMPLNSD GTVMFNATLF
1560 1570 1580 1590 1600
ALVRTALRIK TEEGPSPSEA HQGAEDPFRP AGNLEQANEE LRAIIKKIWK
1610 1620 1630 1640 1650
RTSMKLLDQV VPPAGDDEVT VGKFYATFLI QEYFRKFKKR KEQGLVGKPS
1660 1670 1680 1690 1700
QRNALSLQAG LRTLHDIGPE IRRAISGDLT AEEELDKAMK EAVSAASEDD
1710 1720 1730 1740 1750
IFRRAGGLFG NHVSYYQSDG RSAFPQTFTT QRPLHINKAG SSQGDTESPS
1760 1770 1780 1790 1800
HEKLVDSTFT PSSYSSTGSN ANINNANNTA LGRLPRPAGY PSTVSTVEGH
1810 1820 1830 1840 1850
GPPLSPAIRV QEVAWKLSSN RCHSRESQAA MAGQEETSQD ETYEVKMNHD
1860 1870 1880 1890 1900
TEACSEPSLL STEMLSYQDD ENRQLTLPEE DKRDIRQSPK RGFLRSASLG
1910 1920 1930 1940 1950
RRASFHLECL KRQKDRGGDI SQKTVLPLHL VHHQALAVAG LSPLLQRSHS
1960 1970 1980 1990 2000
PASFPRPFAT PPATPGSRGW PPQPVPTLRL EGVESSEKLN SSFPSIHCGS
2010 2020 2030 2040 2050
WAETTPGGGG SSAARRVRPV SLMVPSQAGA PGRQFHGSAS SLVEAVLISE
2060 2070 2080 2090 2100
GLGQFAQDPK FIEVTTQELA DACDMTIEEM ESAADNILSG GAPQSPNGAL
2110 2120 2130 2140
LPFVNCRDAG QDRAGGEEDA GCVRARGRPS EEELQDSRVY VSSL
Length:2,144
Mass (Da):240,216
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iDB5FAF45ABBB5029
Isoform 16 (identifier: Q13936-16) [UniParc]FASTAAdd to basketAdded to basketShow »
The sequence of this isoform differs from the canonical sequence as follows:
1-29: Missing.
372-391: VNDAVGRDWPWIYFVTLIII → MQDAMGYELPWVYFVSLVIF
952-971: Missing.
1325-1352: Missing.
10 20 30 40 50
MNANAAAGLA PEHIPTPGAA LSWQAAIDAA RQAKLMGSAG NATISTVSST
60 70 80 90 100
QRKRQQYGKP KKQGSTTATR PPRALLCLTL KNPIRRACIS IVEWKPFEII
110 120 130 140 150
ILLTIFANCV ALAIYIPFPE DDSNATNSNL ERVEYLFLII FTVEAFLKVI
160 170 180 190 200
AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS AILEQATKAD GANALGGKGA
210 220 230 240 250
GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI
260 270 280 290 300
IIYAIIGLEL FMGKMHKTCY NQEGIADVPA EDDPSPCALE TGHGRQCQNG
310 320 330 340 350
TVCKPGWDGP KHGITNFDNF AFAMLTVFQC ITMEGWTDVL YWMQDAMGYE
360 370 380 390 400
LPWVYFVSLV IFGSFFVLNL VLGVLSGEFS KEREKAKARG DFQKLREKQQ
410 420 430 440 450
LEEDLKGYLD WITQAEDIDP ENEDEGMDEE KPRNMSMPTS ETESVNTENV
460 470 480 490 500
AGGDIEGENC GARLAHRISK SKFSRYWRRW NRFCRRKCRA AVKSNVFYWL
510 520 530 540 550
VIFLVFLNTL TIASEHYNQP NWLTEVQDTA NKALLALFTA EMLLKMYSLG
560 570 580 590 600
LQAYFVSLFN RFDCFVVCGG ILETILVETK IMSPLGISVL RCVRLLRIFK
610 620 630 640 650
ITRYWNSLSN LVASLLNSVR SIASLLLLLF LFIIIFSLLG MQLFGGKFNF
660 670 680 690 700
DEMQTRRSTF DNFPQSLLTV FQILTGEDWN SVMYDGIMAY GGPSFPGMLV
710 720 730 740 750
CIYFIILFIC GNYILLNVFL AIAVDNLADA ESLTSAQKEE EEEKERKKLA
760 770 780 790 800
RTASPEKKQE LVEKPAVGES KEEKIELKSI TADGESPPAT KINMDDLQPN
810 820 830 840 850
ENEDKSPYPN PETTGEEDEE EPEMPVGPRP RPLSELHLKE KAVPMPEASA
860 870 880 890 900
FFIFSSNNRF RLQCHRIVND TIFTNLILFF ILLSSISLAA EDPVQHTSFR
910 920 930 940 950
NHILFYFDIV FTTIFTIEIA LKMTAYGAFL HKGSFCRNYF NILDLLVVSV
960 970 980 990 1000
SLISFGIQSS AINVVKILRV LRVLRPLRAI NRAKGLKHVV QCVFVAIRTI
1010 1020 1030 1040 1050
GNIVIVTTLL QFMFACIGVQ LFKGKLYTCS DSSKQTEAEC KGNYITYKDG
1060 1070 1080 1090 1100
EVDHPIIQPR SWENSKFDFD NVLAAMMALF TVSTFEGWPE LLYRSIDSHT
1110 1120 1130 1140 1150
EDKGPIYNYR VEISIFFIIY IIIIAFFMMN IFVGFVIVTF QEQGEQEYKN
1160 1170 1180 1190 1200
CELDKNQRQC VEYALKARPL RRYIPKNQHQ YKVWYVVNST YFEYLMFVLI
1210 1220 1230 1240 1250
LLNTICLAMQ HYGQSCLFKI AMNILNMLFT GLFTVEMILK LIAFKPKGYF
1260 1270 1280 1290 1300
SDPWNVFDFL IVIGSIIDVI LSETNPAEHT QCSPSMNAEE NSRISITFFR
1310 1320 1330 1340 1350
LFRVMRLVKL LSRGEGIRTL LWTFIKSFQA LPYVALLIVM LFFIYAVIGM
1360 1370 1380 1390 1400
QVFGKIALND TTEINRNNNF QTFPQAVLLL FRCATGEAWQ DIMLACMPGK
1410 1420 1430 1440 1450
KCAPESEPSN STEGETPCGS SFAVFYFISF YMLCAFLIIN LFVAVIMDNF
1460 1470 1480 1490 1500
DYLTRDWSIL GPHHLDEFKR IWAEYDPEAK GRIKHLDVVT LLRRIQPPLG
1510 1520 1530 1540 1550
FGKLCPHRVA CKRLVSMNMP LNSDGTVMFN ATLFALVRTA LRIKTEGNLE
1560 1570 1580 1590 1600
QANEELRAII KKIWKRTSMK LLDQVVPPAG DDEVTVGKFY ATFLIQEYFR
1610 1620 1630 1640 1650
KFKKRKEQGL VGKPSQRNAL SLQAGLRTLH DIGPEIRRAI SGDLTAEEEL
1660 1670 1680 1690 1700
DKAMKEAVSA ASEDDIFRRA GGLFGNHVSY YQSDGRSAFP QTFTTQRPLH
1710 1720 1730 1740 1750
INKAGSSQGD TESPSHEKLV DSTFTPSSYS STGSNANINN ANNTALGRLP
1760 1770 1780 1790 1800
RPAGYPSTVS TVEGHGPPLS PAIRVQEVAW KLSSNRERHV PMCEDLELRR
1810 1820 1830 1840 1850
DSGSAGTQAH CLLLRKANPS RCHSRESQAA MAGQEETSQD ETYEVKMNHD
1860 1870 1880 1890 1900
TEACSEPSLL STEMLSYQDD ENRQLTLPEE DKRDIRQSPK RGFLRSASLG
1910 1920 1930 1940 1950
RRASFHLECL KRQKDRGGDI SQKTVLPLHL VHHQALAVAG LSPLLQRSHS
1960 1970 1980 1990 2000
PASFPRPFAT PPATPGSRGW PPQPVPTLRL EGVESSEKLN SSFPSIHCGS
2010 2020 2030 2040 2050
WAETTPGGGG SSAARRVRPV SLMVPSQAGA PGRQFHGSAS SLVEAVLISE
2060 2070 2080 2090 2100
GLGQFAQDPK FIEVTTQELA DACDMTIEEM ESAADNILSG GAPQSPNGAL
2110 2120 2130 2140
LPFVNCRDAG QDRAGGEEDA GCVRARGRPS EEELQDSRVY VSSL
Length:2,144
Mass (Da):240,337
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iC12EBA539FF14497
Isoform 17 (identifier: Q13936-17) [UniParc]FASTAAdd to basketAdded to basketShow »
The sequence of this isoform differs from the canonical sequence as follows:
1-29: Missing.
372-391: VNDAVGRDWPWIYFVTLIII → MQDAMGYELPWVYFVSLVIF
952-971: Missing.
1325-1352: Missing.
1864-1898: Missing.
10 20 30 40 50
MNANAAAGLA PEHIPTPGAA LSWQAAIDAA RQAKLMGSAG NATISTVSST
60 70 80 90 100
QRKRQQYGKP KKQGSTTATR PPRALLCLTL KNPIRRACIS IVEWKPFEII
110 120 130 140 150
ILLTIFANCV ALAIYIPFPE DDSNATNSNL ERVEYLFLII FTVEAFLKVI
160 170 180 190 200
AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS AILEQATKAD GANALGGKGA
210 220 230 240 250
GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI
260 270 280 290 300
IIYAIIGLEL FMGKMHKTCY NQEGIADVPA EDDPSPCALE TGHGRQCQNG
310 320 330 340 350
TVCKPGWDGP KHGITNFDNF AFAMLTVFQC ITMEGWTDVL YWMQDAMGYE
360 370 380 390 400
LPWVYFVSLV IFGSFFVLNL VLGVLSGEFS KEREKAKARG DFQKLREKQQ
410 420 430 440 450
LEEDLKGYLD WITQAEDIDP ENEDEGMDEE KPRNMSMPTS ETESVNTENV
460 470 480 490 500
AGGDIEGENC GARLAHRISK SKFSRYWRRW NRFCRRKCRA AVKSNVFYWL
510 520 530 540 550
VIFLVFLNTL TIASEHYNQP NWLTEVQDTA NKALLALFTA EMLLKMYSLG
560 570 580 590 600
LQAYFVSLFN RFDCFVVCGG ILETILVETK IMSPLGISVL RCVRLLRIFK
610 620 630 640 650
ITRYWNSLSN LVASLLNSVR SIASLLLLLF LFIIIFSLLG MQLFGGKFNF
660 670 680 690 700
DEMQTRRSTF DNFPQSLLTV FQILTGEDWN SVMYDGIMAY GGPSFPGMLV
710 720 730 740 750
CIYFIILFIC GNYILLNVFL AIAVDNLADA ESLTSAQKEE EEEKERKKLA
760 770 780 790 800
RTASPEKKQE LVEKPAVGES KEEKIELKSI TADGESPPAT KINMDDLQPN
810 820 830 840 850
ENEDKSPYPN PETTGEEDEE EPEMPVGPRP RPLSELHLKE KAVPMPEASA
860 870 880 890 900
FFIFSSNNRF RLQCHRIVND TIFTNLILFF ILLSSISLAA EDPVQHTSFR
910 920 930 940 950
NHILFYFDIV FTTIFTIEIA LKMTAYGAFL HKGSFCRNYF NILDLLVVSV
960 970 980 990 1000
SLISFGIQSS AINVVKILRV LRVLRPLRAI NRAKGLKHVV QCVFVAIRTI
1010 1020 1030 1040 1050
GNIVIVTTLL QFMFACIGVQ LFKGKLYTCS DSSKQTEAEC KGNYITYKDG
1060 1070 1080 1090 1100
EVDHPIIQPR SWENSKFDFD NVLAAMMALF TVSTFEGWPE LLYRSIDSHT
1110 1120 1130 1140 1150
EDKGPIYNYR VEISIFFIIY IIIIAFFMMN IFVGFVIVTF QEQGEQEYKN
1160 1170 1180 1190 1200
CELDKNQRQC VEYALKARPL RRYIPKNQHQ YKVWYVVNST YFEYLMFVLI
1210 1220 1230 1240 1250
LLNTICLAMQ HYGQSCLFKI AMNILNMLFT GLFTVEMILK LIAFKPKGYF
1260 1270 1280 1290 1300
SDPWNVFDFL IVIGSIIDVI LSETNPAEHT QCSPSMNAEE NSRISITFFR
1310 1320 1330 1340 1350
LFRVMRLVKL LSRGEGIRTL LWTFIKSFQA LPYVALLIVM LFFIYAVIGM
1360 1370 1380 1390 1400
QVFGKIALND TTEINRNNNF QTFPQAVLLL FRCATGEAWQ DIMLACMPGK
1410 1420 1430 1440 1450
KCAPESEPSN STEGETPCGS SFAVFYFISF YMLCAFLIIN LFVAVIMDNF
1460 1470 1480 1490 1500
DYLTRDWSIL GPHHLDEFKR IWAEYDPEAK GRIKHLDVVT LLRRIQPPLG
1510 1520 1530 1540 1550
FGKLCPHRVA CKRLVSMNMP LNSDGTVMFN ATLFALVRTA LRIKTEGNLE
1560 1570 1580 1590 1600
QANEELRAII KKIWKRTSMK LLDQVVPPAG DDEVTVGKFY ATFLIQEYFR
1610 1620 1630 1640 1650
KFKKRKEQGL VGKPSQRNAL SLQAGLRTLH DIGPEIRRAI SGDLTAEEEL
1660 1670 1680 1690 1700
DKAMKEAVSA ASEDDIFRRA GGLFGNHVSY YQSDGRSAFP QTFTTQRPLH
1710 1720 1730 1740 1750
INKAGSSQGD TESPSHEKLV DSTFTPSSYS STGSNANINN ANNTALGRLP
1760 1770 1780 1790 1800
RPAGYPSTVS TVEGHGPPLS PAIRVQEVAW KLSSNRCHSR ESQAAMAGQE
1810 1820 1830 1840 1850
ETSQDETYEV KMNHDTEACS EPSLLSTEML SYQDDENRQL TLPEEDKRDI
1860 1870 1880 1890 1900
RQSPKRGFLR SASLGRRASF HLECLKRQKD RGGDISQKTV LPLHLVHHQA
1910 1920 1930 1940 1950
LAVAGLSPLL QRSHSPASFP RPFATPPATP GSRGWPPQPV PTLRLEGVES
1960 1970 1980 1990 2000
SEKLNSSFPS IHCGSWAETT PGGGGSSAAR RVRPVSLMVP SQAGAPGRQF
2010 2020 2030 2040 2050
HGSASSLVEA VLISEGLGQF AQDPKFIEVT TQELADACDM TIEEMESAAD
2060 2070 2080 2090 2100
NILSGGAPQS PNGALLPFVN CRDAGQDRAG GEEDAGCVRA RGRPSEEELQ
DSRVYVSSL
Length:2,109
Mass (Da):236,407
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iC55728B593C24297
Isoform 18 (identifier: Q13936-18) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: HHT-1
The sequence of this isoform differs from the canonical sequence as follows:
1-29: Missing.
372-391: VNDAVGRDWPWIYFVTLIII → MQDAMGYELPWVYFVSLVIF
952-971: Missing.
1325-1352: Missing.
1864-1897: ERHVPMCEDLELRRDSGSAGTQAHCLLLRKANPS → MHCCDMLDGG...PAGCTAPQHA
10 20 30 40 50
MNANAAAGLA PEHIPTPGAA LSWQAAIDAA RQAKLMGSAG NATISTVSST
60 70 80 90 100
QRKRQQYGKP KKQGSTTATR PPRALLCLTL KNPIRRACIS IVEWKPFEII
110 120 130 140 150
ILLTIFANCV ALAIYIPFPE DDSNATNSNL ERVEYLFLII FTVEAFLKVI
160 170 180 190 200
AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS AILEQATKAD GANALGGKGA
210 220 230 240 250
GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI
260 270 280 290 300
IIYAIIGLEL FMGKMHKTCY NQEGIADVPA EDDPSPCALE TGHGRQCQNG
310 320 330 340 350
TVCKPGWDGP KHGITNFDNF AFAMLTVFQC ITMEGWTDVL YWMQDAMGYE
360 370 380 390 400
LPWVYFVSLV IFGSFFVLNL VLGVLSGEFS KEREKAKARG DFQKLREKQQ
410 420 430 440 450
LEEDLKGYLD WITQAEDIDP ENEDEGMDEE KPRNMSMPTS ETESVNTENV
460 470 480 490 500
AGGDIEGENC GARLAHRISK SKFSRYWRRW NRFCRRKCRA AVKSNVFYWL
510 520 530 540 550
VIFLVFLNTL TIASEHYNQP NWLTEVQDTA NKALLALFTA EMLLKMYSLG
560 570 580 590 600
LQAYFVSLFN RFDCFVVCGG ILETILVETK IMSPLGISVL RCVRLLRIFK
610 620 630 640 650
ITRYWNSLSN LVASLLNSVR SIASLLLLLF LFIIIFSLLG MQLFGGKFNF
660 670 680 690 700
DEMQTRRSTF DNFPQSLLTV FQILTGEDWN SVMYDGIMAY GGPSFPGMLV
710 720 730 740 750
CIYFIILFIC GNYILLNVFL AIAVDNLADA ESLTSAQKEE EEEKERKKLA
760 770 780 790 800
RTASPEKKQE LVEKPAVGES KEEKIELKSI TADGESPPAT KINMDDLQPN
810 820 830 840 850
ENEDKSPYPN PETTGEEDEE EPEMPVGPRP RPLSELHLKE KAVPMPEASA
860 870 880 890 900
FFIFSSNNRF RLQCHRIVND TIFTNLILFF ILLSSISLAA EDPVQHTSFR
910 920 930 940 950
NHILFYFDIV FTTIFTIEIA LKMTAYGAFL HKGSFCRNYF NILDLLVVSV
960 970 980 990 1000
SLISFGIQSS AINVVKILRV LRVLRPLRAI NRAKGLKHVV QCVFVAIRTI
1010 1020 1030 1040 1050
GNIVIVTTLL QFMFACIGVQ LFKGKLYTCS DSSKQTEAEC KGNYITYKDG
1060 1070 1080 1090 1100
EVDHPIIQPR SWENSKFDFD NVLAAMMALF TVSTFEGWPE LLYRSIDSHT
1110 1120 1130 1140 1150
EDKGPIYNYR VEISIFFIIY IIIIAFFMMN IFVGFVIVTF QEQGEQEYKN
1160 1170 1180 1190 1200
CELDKNQRQC VEYALKARPL RRYIPKNQHQ YKVWYVVNST YFEYLMFVLI
1210 1220 1230 1240 1250
LLNTICLAMQ HYGQSCLFKI AMNILNMLFT GLFTVEMILK LIAFKPKGYF
1260 1270 1280 1290 1300
SDPWNVFDFL IVIGSIIDVI LSETNPAEHT QCSPSMNAEE NSRISITFFR
1310 1320 1330 1340 1350
LFRVMRLVKL LSRGEGIRTL LWTFIKSFQA LPYVALLIVM LFFIYAVIGM
1360 1370 1380 1390 1400
QVFGKIALND TTEINRNNNF QTFPQAVLLL FRCATGEAWQ DIMLACMPGK
1410 1420 1430 1440 1450
KCAPESEPSN STEGETPCGS SFAVFYFISF YMLCAFLIIN LFVAVIMDNF
1460 1470 1480 1490 1500
DYLTRDWSIL GPHHLDEFKR IWAEYDPEAK GRIKHLDVVT LLRRIQPPLG
1510 1520 1530 1540 1550
FGKLCPHRVA CKRLVSMNMP LNSDGTVMFN ATLFALVRTA LRIKTEGNLE
1560 1570 1580 1590 1600
QANEELRAII KKIWKRTSMK LLDQVVPPAG DDEVTVGKFY ATFLIQEYFR
1610 1620 1630 1640 1650
KFKKRKEQGL VGKPSQRNAL SLQAGLRTLH DIGPEIRRAI SGDLTAEEEL
1660 1670 1680 1690 1700
DKAMKEAVSA ASEDDIFRRA GGLFGNHVSY YQSDGRSAFP QTFTTQRPLH
1710 1720 1730 1740 1750
INKAGSSQGD TESPSHEKLV DSTFTPSSYS STGSNANINN ANNTALGRLP
1760 1770 1780 1790 1800
RPAGYPSTVS TVEGHGPPLS PAIRVQEVAW KLSSNRMHCC DMLDGGTFPP
1810 1820 1830 1840 1850
ALGPRRAPPC LHQQLQGSLA GLREDTPCIV PGHASLCCSS RVGEWLPAGC
1860 1870 1880 1890 1900
TAPQHARCHS RESQAAMAGQ EETSQDETYE VKMNHDTEAC SEPSLLSTEM
1910 1920 1930 1940 1950
LSYQDDENRQ LTLPEEDKRD IRQSPKRGFL RSASLGRRAS FHLECLKRQK
1960 1970 1980 1990 2000
DRGGDISQKT VLPLHLVHHQ ALAVAGLSPL LQRSHSPASF PRPFATPPAT
2010 2020 2030 2040 2050
PGSRGWPPQP VPTLRLEGVE SSEKLNSSFP SIHCGSWAET TPGGGGSSAA
2060 2070 2080 2090 2100
RRVRPVSLMV PSQAGAPGRQ FHGSASSLVE AVLISEGLGQ FAQDPKFIEV
2110 2120 2130 2140 2150
TTQELADACD MTIEEMESAA DNILSGGAPQ SPNGALLPFV NCRDAGQDRA
2160 2170 2180
GGEEDAGCVR ARGRPSEEEL QDSRVYVSSL
Length:2,180
Mass (Da):243,867
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iBDAC026FE2CACCDF
Isoform 19 (identifier: Q13936-19) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.76
The sequence of this isoform differs from the canonical sequence as follows:
932-951: Missing.
1297-1324: Missing.
1353-1363: Missing.
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TEVNNAEENS RISITFFRLF RVMRLVKLLS RGEGIRTLLW TFIKSFQALP
1360 1370 1380 1390 1400
YVALLIVMLF FIYAVIGMQV FGKIALNDTT EINRNNNFQT FPQAVLLLFR
1410 1420 1430 1440 1450
CATGEAWQDI MLACMPGKKC APESEPSNST EGETPCGSSF AVFYFISFYM
1460 1470 1480 1490 1500
LCAFLIINLF VAVIMDNFDY LTRDWSILGP HHLDEFKRIW AEYDPEAKGR
1510 1520 1530 1540 1550
IKHLDVVTLL RRIQPPLGFG KLCPHRVACK RLVSMNMPLN SDGTVMFNAT
1560 1570 1580 1590 1600
LFALVRTALR IKTEGNLEQA NEELRAIIKK IWKRTSMKLL DQVVPPAGDD
1610 1620 1630 1640 1650
EVTVGKFYAT FLIQEYFRKF KKRKEQGLVG KPSQRNALSL QAGLRTLHDI
1660 1670 1680 1690 1700
GPEIRRAISG DLTAEEELDK AMKEAVSAAS EDDIFRRAGG LFGNHVSYYQ
1710 1720 1730 1740 1750
SDGRSAFPQT FTTQRPLHIN KAGSSQGDTE SPSHEKLVDS TFTPSSYSST
1760 1770 1780 1790 1800
GSNANINNAN NTALGRLPRP AGYPSTVSTV EGHGPPLSPA IRVQEVAWKL
1810 1820 1830 1840 1850
SSNRCHSRES QAAMAGQEET SQDETYEVKM NHDTEACSEP SLLSTEMLSY
1860 1870 1880 1890 1900
QDDENRQLTL PEEDKRDIRQ SPKRGFLRSA SLGRRASFHL ECLKRQKDRG
1910 1920 1930 1940 1950
GDISQKTVLP LHLVHHQALA VAGLSPLLQR SHSPASFPRP FATPPATPGS
1960 1970 1980 1990 2000
RGWPPQPVPT LRLEGVESSE KLNSSFPSIH CGSWAETTPG GGGSSAARRV
2010 2020 2030 2040 2050
RPVSLMVPSQ AGAPGRQFHG SASSLVEAVL ISEGLGQFAQ DPKFIEVTTQ
2060 2070 2080 2090 2100
ELADACDMTI EEMESAADNI LSGGAPQSPN GALLPFVNCR DAGQDRAGGE
2110 2120
EDAGCVRARG RPSEEELQDS RVYVSSL
Length:2,127
Mass (Da):238,331
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i8F48E5719F6E9E1A
Isoform 20 (identifier: Q13936-20) [UniParc]FASTAAdd to basketAdded to basket
Also known as: Alpha-1C.77
The sequence of this isoform differs from the canonical sequence as follows:
932-951: Missing.
1297-1324: Missing.
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TEVNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL
1610 1620 1630 1640 1650
LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS
1660 1670 1680 1690 1700
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG
1710 1720 1730 1740 1750
GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI NKAGSSQGDT ESPSHEKLVD
1760 1770 1780 1790 1800
STFTPSSYSS TGSNANINNA NNTALGRLPR PAGYPSTVST VEGHGPPLSP
1810 1820 1830 1840 1850
AIRVQEVAWK LSSNRCHSRE SQAAMAGQEE TSQDETYEVK MNHDTEACSE
1860 1870 1880 1890 1900
PSLLSTEMLS YQDDENRQLT LPEEDKRDIR QSPKRGFLRS ASLGRRASFH
1910 1920 1930 1940 1950
LECLKRQKDR GGDISQKTVL PLHLVHHQAL AVAGLSPLLQ RSHSPASFPR
1960 1970 1980 1990 2000
PFATPPATPG SRGWPPQPVP TLRLEGVESS EKLNSSFPSI HCGSWAETTP
2010 2020 2030 2040 2050
GGGGSSAARR VRPVSLMVPS QAGAPGRQFH GSASSLVEAV LISEGLGQFA
2060 2070 2080 2090 2100
QDPKFIEVTT QELADACDMT IEEMESAADN ILSGGAPQSP NGALLPFVNC
2110 2120 2130
RDAGQDRAGG EEDAGCVRAR GRPSEEELQD SRVYVSSL
Note: Predominant isoform in atherosclerotic vascular smooth muscle cells.
Show »Length:2,138
Mass (Da):239,501
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iD79ED1D29A7A8BC4
Isoform 21 (identifier: Q13936-21) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.69
The sequence of this isoform differs from the canonical sequence as follows:
932-951: Missing.
1325-1352: Missing.
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL
1310 1320 1330 1340 1350
SETNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL
1610 1620 1630 1640 1650
LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS
1660 1670 1680 1690 1700
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG
1710 1720 1730 1740 1750
GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI NKAGSSQGDT ESPSHEKLVD
1760 1770 1780 1790 1800
STFTPSSYSS TGSNANINNA NNTALGRLPR PAGYPSTVST VEGHGPPLSP
1810 1820 1830 1840 1850
AIRVQEVAWK LSSNRCHSRE SQAAMAGQEE TSQDETYEVK MNHDTEACSE
1860 1870 1880 1890 1900
PSLLSTEMLS YQDDENRQLT LPEEDKRDIR QSPKRGFLRS ASLGRRASFH
1910 1920 1930 1940 1950
LECLKRQKDR GGDISQKTVL PLHLVHHQAL AVAGLSPLLQ RSHSPASFPR
1960 1970 1980 1990 2000
PFATPPATPG SRGWPPQPVP TLRLEGVESS EKLNSSFPSI HCGSWAETTP
2010 2020 2030 2040 2050
GGGGSSAARR VRPVSLMVPS QAGAPGRQFH GSASSLVEAV LISEGLGQFA
2060 2070 2080 2090 2100
QDPKFIEVTT QELADACDMT IEEMESAADN ILSGGAPQSP NGALLPFVNC
2110 2120 2130
RDAGQDRAGG EEDAGCVRAR GRPSEEELQD SRVYVSSL
Length:2,138
Mass (Da):239,549
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i543CE8B026838D86
Isoform 22 (identifier: Q13936-22) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.78
The sequence of this isoform differs from the canonical sequence as follows:
952-971: Missing.
1325-1352: Missing.
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL
1310 1320 1330 1340 1350
SETNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL
1610 1620 1630 1640 1650
LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS
1660 1670 1680 1690 1700
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG
1710 1720 1730 1740 1750
GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI NKAGSSQGDT ESPSHEKLVD
1760 1770 1780 1790 1800
STFTPSSYSS TGSNANINNA NNTALGRLPR PAGYPSTVST VEGHGPPLSP
1810 1820 1830 1840 1850
AIRVQEVAWK LSSNRCHSRE SQAAMAGQEE TSQDETYEVK MNHDTEACSE
1860 1870 1880 1890 1900
PSLLSTEMLS YQDDENRQLT LPEEDKRDIR QSPKRGFLRS ASLGRRASFH
1910 1920 1930 1940 1950
LECLKRQKDR GGDISQKTVL PLHLVHHQAL AVAGLSPLLQ RSHSPASFPR
1960 1970 1980 1990 2000
PFATPPATPG SRGWPPQPVP TLRLEGVESS EKLNSSFPSI HCGSWAETTP
2010 2020 2030 2040 2050
GGGGSSAARR VRPVSLMVPS QAGAPGRQFH GSASSLVEAV LISEGLGQFA
2060 2070 2080 2090 2100
QDPKFIEVTT QELADACDMT IEEMESAADN ILSGGAPQSP NGALLPFVNC
2110 2120 2130
RDAGQDRAGG EEDAGCVRAR GRPSEEELQD SRVYVSSL
Length:2,138
Mass (Da):239,686
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iA3AF906748C0D52B
Isoform 23 (identifier: Q13936-23) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.105
The sequence of this isoform differs from the canonical sequence as follows:
372-391: VNDAVGRDWPWIYFVTLIII → MQDAMGYELPWVYFVSLVIF
932-951: Missing.
1297-1324: Missing.
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI FGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TEVNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL
1610 1620 1630 1640 1650
LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS
1660 1670 1680 1690 1700
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG
1710 1720 1730 1740 1750
GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI NKAGSSQGDT ESPSHEKLVD
1760 1770 1780 1790 1800
STFTPSSYSS TGSNANINNA NNTALGRLPR PAGYPSTVST VEGHGPPLSP
1810 1820 1830 1840 1850
AIRVQEVAWK LSSNRCHSRE SQAAMAGQEE TSQDETYEVK MNHDTEACSE
1860 1870 1880 1890 1900
PSLLSTEMLS YQDDENRQLT LPEEDKRDIR QSPKRGFLRS ASLGRRASFH
1910 1920 1930 1940 1950
LECLKRQKDR GGDISQKTVL PLHLVHHQAL AVAGLSPLLQ RSHSPASFPR
1960 1970 1980 1990 2000
PFATPPATPG SRGWPPQPVP TLRLEGVESS EKLNSSFPSI HCGSWAETTP
2010 2020 2030 2040 2050
GGGGSSAARR VRPVSLMVPS QAGAPGRQFH GSASSLVEAV LISEGLGQFA
2060 2070 2080 2090 2100
QDPKFIEVTT QELADACDMT IEEMESAADN ILSGGAPQSP NGALLPFVNC
2110 2120 2130
RDAGQDRAGG EEDAGCVRAR GRPSEEELQD SRVYVSSL
Length:2,138
Mass (Da):239,519
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i5CB0952B62394E78
Isoform 24 (identifier: Q13936-24) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.71
The sequence of this isoform differs from the canonical sequence as follows:
952-971: Missing.
1297-1324: Missing.
1623-1623: E → EEGPSPSEAHQGAEDPFRPA
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TEVNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEEGPSP SEAHQGAEDP FRPAGNLEQA
1610 1620 1630 1640 1650
NEELRAIIKK IWKRTSMKLL DQVVPPAGDD EVTVGKFYAT FLIQEYFRKF
1660 1670 1680 1690 1700
KKRKEQGLVG KPSQRNALSL QAGLRTLHDI GPEIRRAISG DLTAEEELDK
1710 1720 1730 1740 1750
AMKEAVSAAS EDDIFRRAGG LFGNHVSYYQ SDGRSAFPQT FTTQRPLHIN
1760 1770 1780 1790 1800
KAGSSQGDTE SPSHEKLVDS TFTPSSYSST GSNANINNAN NTALGRLPRP
1810 1820 1830 1840 1850
AGYPSTVSTV EGHGPPLSPA IRVQEVAWKL SSNRCHSRES QAAMAGQEET
1860 1870 1880 1890 1900
SQDETYEVKM NHDTEACSEP SLLSTEMLSY QDDENRQLTL PEEDKRDIRQ
1910 1920 1930 1940 1950
SPKRGFLRSA SLGRRASFHL ECLKRQKDRG GDISQKTVLP LHLVHHQALA
1960 1970 1980 1990 2000
VAGLSPLLQR SHSPASFPRP FATPPATPGS RGWPPQPVPT LRLEGVESSE
2010 2020 2030 2040 2050
KLNSSFPSIH CGSWAETTPG GGGSSAARRV RPVSLMVPSQ AGAPGRQFHG
2060 2070 2080 2090 2100
SASSLVEAVL ISEGLGQFAQ DPKFIEVTTQ ELADACDMTI EEMESAADNI
2110 2120 2130 2140 2150
LSGGAPQSPN GALLPFVNCR DAGQDRAGGE EDAGCVRARG RPSEEELQDS
RVYVSSL
Length:2,157
Mass (Da):241,599
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iC4AAB050CF536648
Isoform 25 (identifier: Q13936-25) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.73
The sequence of this isoform differs from the canonical sequence as follows:
952-971: Missing.
1297-1324: Missing.
1353-1363: Missing.
1623-1623: E → EEGPSPSEAHQGAEDPFRPA
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TEVNNAEENS RISITFFRLF RVMRLVKLLS RGEGIRTLLW TFIKSFQALP
1360 1370 1380 1390 1400
YVALLIVMLF FIYAVIGMQV FGKIALNDTT EINRNNNFQT FPQAVLLLFR
1410 1420 1430 1440 1450
CATGEAWQDI MLACMPGKKC APESEPSNST EGETPCGSSF AVFYFISFYM
1460 1470 1480 1490 1500
LCAFLIINLF VAVIMDNFDY LTRDWSILGP HHLDEFKRIW AEYDPEAKGR
1510 1520 1530 1540 1550
IKHLDVVTLL RRIQPPLGFG KLCPHRVACK RLVSMNMPLN SDGTVMFNAT
1560 1570 1580 1590 1600
LFALVRTALR IKTEEGPSPS EAHQGAEDPF RPAGNLEQAN EELRAIIKKI
1610 1620 1630 1640 1650
WKRTSMKLLD QVVPPAGDDE VTVGKFYATF LIQEYFRKFK KRKEQGLVGK
1660 1670 1680 1690 1700
PSQRNALSLQ AGLRTLHDIG PEIRRAISGD LTAEEELDKA MKEAVSAASE
1710 1720 1730 1740 1750
DDIFRRAGGL FGNHVSYYQS DGRSAFPQTF TTQRPLHINK AGSSQGDTES
1760 1770 1780 1790 1800
PSHEKLVDST FTPSSYSSTG SNANINNANN TALGRLPRPA GYPSTVSTVE
1810 1820 1830 1840 1850
GHGPPLSPAI RVQEVAWKLS SNRCHSRESQ AAMAGQEETS QDETYEVKMN
1860 1870 1880 1890 1900
HDTEACSEPS LLSTEMLSYQ DDENRQLTLP EEDKRDIRQS PKRGFLRSAS
1910 1920 1930 1940 1950
LGRRASFHLE CLKRQKDRGG DISQKTVLPL HLVHHQALAV AGLSPLLQRS
1960 1970 1980 1990 2000
HSPASFPRPF ATPPATPGSR GWPPQPVPTL RLEGVESSEK LNSSFPSIHC
2010 2020 2030 2040 2050
GSWAETTPGG GGSSAARRVR PVSLMVPSQA GAPGRQFHGS ASSLVEAVLI
2060 2070 2080 2090 2100
SEGLGQFAQD PKFIEVTTQE LADACDMTIE EMESAADNIL SGGAPQSPNG
2110 2120 2130 2140
ALLPFVNCRD AGQDRAGGEE DAGCVRARGR PSEEELQDSR VYVSSL
Length:2,146
Mass (Da):240,430
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iAA7E9FA59B52D8F8
Isoform 26 (identifier: Q13936-26) [UniParc]FASTAAdd to basketAdded to basket
Also known as: Alpha-1C.86
The sequence of this isoform differs from the canonical sequence as follows:
932-951: Missing.
1297-1324: Missing.
1618-1699: LRIKTEGNLE...KPSQRNALSL → LREAELSSQV...RGPHHPPLGF
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TEVNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL REAELSSQVQ YQAKEASLLE RRRKSSHPKS
1610 1620 1630 1640 1650
STKPNKLLSS GGSTGWVEDA RALEGQVLAR GCGWLGSLEE RERGPHHPPL
1660 1670 1680 1690 1700
GFQAGLRTLH DIGPEIRRAI SGDLTAEEEL DKAMKEAVSA ASEDDIFRRA
1710 1720 1730 1740 1750
GGLFGNHVSY YQSDGRSAFP QTFTTQRPLH INKAGSSQGD TESPSHEKLV
1760 1770 1780 1790 1800
DSTFTPSSYS STGSNANINN ANNTALGRLP RPAGYPSTVS TVEGHGPPLS
1810 1820 1830 1840 1850
PAIRVQEVAW KLSSNRCHSR ESQAAMAGQE ETSQDETYEV KMNHDTEACS
1860 1870 1880 1890 1900
EPSLLSTEML SYQDDENRQL TLPEEDKRDI RQSPKRGFLR SASLGRRASF
1910 1920 1930 1940 1950
HLECLKRQKD RGGDISQKTV LPLHLVHHQA LAVAGLSPLL QRSHSPASFP
1960 1970 1980 1990 2000
RPFATPPATP GSRGWPPQPV PTLRLEGVES SEKLNSSFPS IHCGSWAETT
2010 2020 2030 2040 2050
PGGGGSSAAR RVRPVSLMVP SQAGAPGRQF HGSASSLVEA VLISEGLGQF
2060 2070 2080 2090 2100
AQDPKFIEVT TQELADACDM TIEEMESAAD NILSGGAPQS PNGALLPFVN
2110 2120 2130
CRDAGQDRAG GEEDAGCVRA RGRPSEEELQ DSRVYVSSL
Note: Not inhibited by calcium.
Show »Length:2,139
Mass (Da):239,131
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i6EB51667F5ABD712
Isoform 27 (identifier: Q13936-27) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.72
The sequence of this isoform differs from the canonical sequence as follows:
932-951: Missing.
1297-1324: Missing.
1623-1623: E → EEGPSPSEAHQGAEDPFRPA
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TEVNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEEGPSP SEAHQGAEDP FRPAGNLEQA
1610 1620 1630 1640 1650
NEELRAIIKK IWKRTSMKLL DQVVPPAGDD EVTVGKFYAT FLIQEYFRKF
1660 1670 1680 1690 1700
KKRKEQGLVG KPSQRNALSL QAGLRTLHDI GPEIRRAISG DLTAEEELDK
1710 1720 1730 1740 1750
AMKEAVSAAS EDDIFRRAGG LFGNHVSYYQ SDGRSAFPQT FTTQRPLHIN
1760 1770 1780 1790 1800
KAGSSQGDTE SPSHEKLVDS TFTPSSYSST GSNANINNAN NTALGRLPRP
1810 1820 1830 1840 1850
AGYPSTVSTV EGHGPPLSPA IRVQEVAWKL SSNRCHSRES QAAMAGQEET
1860 1870 1880 1890 1900
SQDETYEVKM NHDTEACSEP SLLSTEMLSY QDDENRQLTL PEEDKRDIRQ
1910 1920 1930 1940 1950
SPKRGFLRSA SLGRRASFHL ECLKRQKDRG GDISQKTVLP LHLVHHQALA
1960 1970 1980 1990 2000
VAGLSPLLQR SHSPASFPRP FATPPATPGS RGWPPQPVPT LRLEGVESSE
2010 2020 2030 2040 2050
KLNSSFPSIH CGSWAETTPG GGGSSAARRV RPVSLMVPSQ AGAPGRQFHG
2060 2070 2080 2090 2100
SASSLVEAVL ISEGLGQFAQ DPKFIEVTTQ ELADACDMTI EEMESAADNI
2110 2120 2130 2140 2150
LSGGAPQSPN GALLPFVNCR DAGQDRAGGE EDAGCVRARG RPSEEELQDS
RVYVSSL
Length:2,157
Mass (Da):241,462
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iC2DE4EA2A12B1F77
Isoform 28 (identifier: Q13936-28) [UniParc]FASTAAdd to basketAdded to basketShow »
The sequence of this isoform differs from the canonical sequence as follows:
1-29: Missing.
372-391: VNDAVGRDWPWIYFVTLIII → MQDAMGYELPWVYFVSLVIF
952-971: Missing.
1297-1324: Missing.
1353-1363: Missing.
1864-1897: ERHVPMCEDLELRRDSGSAGTQAHCLLLRKANPS → MHCCDMLDGG...PAGCTAPQHA
10 20 30 40 50
MNANAAAGLA PEHIPTPGAA LSWQAAIDAA RQAKLMGSAG NATISTVSST
60 70 80 90 100
QRKRQQYGKP KKQGSTTATR PPRALLCLTL KNPIRRACIS IVEWKPFEII
110 120 130 140 150
ILLTIFANCV ALAIYIPFPE DDSNATNSNL ERVEYLFLII FTVEAFLKVI
160 170 180 190 200
AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS AILEQATKAD GANALGGKGA
210 220 230 240 250
GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI
260 270 280 290 300
IIYAIIGLEL FMGKMHKTCY NQEGIADVPA EDDPSPCALE TGHGRQCQNG
310 320 330 340 350
TVCKPGWDGP KHGITNFDNF AFAMLTVFQC ITMEGWTDVL YWMQDAMGYE
360 370 380 390 400
LPWVYFVSLV IFGSFFVLNL VLGVLSGEFS KEREKAKARG DFQKLREKQQ
410 420 430 440 450
LEEDLKGYLD WITQAEDIDP ENEDEGMDEE KPRNMSMPTS ETESVNTENV
460 470 480 490 500
AGGDIEGENC GARLAHRISK SKFSRYWRRW NRFCRRKCRA AVKSNVFYWL
510 520 530 540 550
VIFLVFLNTL TIASEHYNQP NWLTEVQDTA NKALLALFTA EMLLKMYSLG
560 570 580 590 600
LQAYFVSLFN RFDCFVVCGG ILETILVETK IMSPLGISVL RCVRLLRIFK
610 620 630 640 650
ITRYWNSLSN LVASLLNSVR SIASLLLLLF LFIIIFSLLG MQLFGGKFNF
660 670 680 690 700
DEMQTRRSTF DNFPQSLLTV FQILTGEDWN SVMYDGIMAY GGPSFPGMLV
710 720 730 740 750
CIYFIILFIC GNYILLNVFL AIAVDNLADA ESLTSAQKEE EEEKERKKLA
760 770 780 790 800
RTASPEKKQE LVEKPAVGES KEEKIELKSI TADGESPPAT KINMDDLQPN
810 820 830 840 850
ENEDKSPYPN PETTGEEDEE EPEMPVGPRP RPLSELHLKE KAVPMPEASA
860 870 880 890 900
FFIFSSNNRF RLQCHRIVND TIFTNLILFF ILLSSISLAA EDPVQHTSFR
910 920 930 940 950
NHILFYFDIV FTTIFTIEIA LKMTAYGAFL HKGSFCRNYF NILDLLVVSV
960 970 980 990 1000
SLISFGIQSS AINVVKILRV LRVLRPLRAI NRAKGLKHVV QCVFVAIRTI
1010 1020 1030 1040 1050
GNIVIVTTLL QFMFACIGVQ LFKGKLYTCS DSSKQTEAEC KGNYITYKDG
1060 1070 1080 1090 1100
EVDHPIIQPR SWENSKFDFD NVLAAMMALF TVSTFEGWPE LLYRSIDSHT
1110 1120 1130 1140 1150
EDKGPIYNYR VEISIFFIIY IIIIAFFMMN IFVGFVIVTF QEQGEQEYKN
1160 1170 1180 1190 1200
CELDKNQRQC VEYALKARPL RRYIPKNQHQ YKVWYVVNST YFEYLMFVLI
1210 1220 1230 1240 1250
LLNTICLAMQ HYGQSCLFKI AMNILNMLFT GLFTVEMILK LIAFKPKHYF
1260 1270 1280 1290 1300
CDAWNTFDAL IVVGSIVDIA ITEVNNAEEN SRISITFFRL FRVMRLVKLL
1310 1320 1330 1340 1350
SRGEGIRTLL WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT
1360 1370 1380 1390 1400
TEINRNNNFQ TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS
1410 1420 1430 1440 1450
TEGETPCGSS FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG
1460 1470 1480 1490 1500
PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC
1510 1520 1530 1540 1550
KRLVSMNMPL NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK
1560 1570 1580 1590 1600
KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV
1610 1620 1630 1640 1650
GKPSQRNALS LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA
1660 1670 1680 1690 1700
SEDDIFRRAG GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI NKAGSSQGDT
1710 1720 1730 1740 1750
ESPSHEKLVD STFTPSSYSS TGSNANINNA NNTALGRLPR PAGYPSTVST
1760 1770 1780 1790 1800
VEGHGPPLSP AIRVQEVAWK LSSNRMHCCD MLDGGTFPPA LGPRRAPPCL
1810 1820 1830 1840 1850
HQQLQGSLAG LREDTPCIVP GHASLCCSSR VGEWLPAGCT APQHARCHSR
1860 1870 1880 1890 1900
ESQAAMAGQE ETSQDETYEV KMNHDTEACS EPSLLSTEML SYQDDENRQL
1910 1920 1930 1940 1950
TLPEEDKRDI RQSPKRGFLR SASLGRRASF HLECLKRQKD RGGDISQKTV
1960 1970 1980 1990 2000
LPLHLVHHQA LAVAGLSPLL QRSHSPASFP RPFATPPATP GSRGWPPQPV
2010 2020 2030 2040 2050
PTLRLEGVES SEKLNSSFPS IHCGSWAETT PGGGGSSAAR RVRPVSLMVP
2060 2070 2080 2090 2100
SQAGAPGRQF HGSASSLVEA VLISEGLGQF AQDPKFIEVT TQELADACDM
2110 2120 2130 2140 2150
TIEEMESAAD NILSGGAPQS PNGALLPFVN CRDAGQDRAG GEEDAGCVRA
2160
RGRPSEEELQ DSRVYVSSL
Length:2,169
Mass (Da):242,650
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i53DBBEE14BEAB4C6
Isoform 29 (identifier: Q13936-29) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.74
The sequence of this isoform differs from the canonical sequence as follows:
932-951: Missing.
1297-1324: Missing.
1353-1363: Missing.
1623-1623: E → EEGPSPSEAHQGAEDPFRPA
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TEVNNAEENS RISITFFRLF RVMRLVKLLS RGEGIRTLLW TFIKSFQALP
1360 1370 1380 1390 1400
YVALLIVMLF FIYAVIGMQV FGKIALNDTT EINRNNNFQT FPQAVLLLFR
1410 1420 1430 1440 1450
CATGEAWQDI MLACMPGKKC APESEPSNST EGETPCGSSF AVFYFISFYM
1460 1470 1480 1490 1500
LCAFLIINLF VAVIMDNFDY LTRDWSILGP HHLDEFKRIW AEYDPEAKGR
1510 1520 1530 1540 1550
IKHLDVVTLL RRIQPPLGFG KLCPHRVACK RLVSMNMPLN SDGTVMFNAT
1560 1570 1580 1590 1600
LFALVRTALR IKTEEGPSPS EAHQGAEDPF RPAGNLEQAN EELRAIIKKI
1610 1620 1630 1640 1650
WKRTSMKLLD QVVPPAGDDE VTVGKFYATF LIQEYFRKFK KRKEQGLVGK
1660 1670 1680 1690 1700
PSQRNALSLQ AGLRTLHDIG PEIRRAISGD LTAEEELDKA MKEAVSAASE
1710 1720 1730 1740 1750
DDIFRRAGGL FGNHVSYYQS DGRSAFPQTF TTQRPLHINK AGSSQGDTES
1760 1770 1780 1790 1800
PSHEKLVDST FTPSSYSSTG SNANINNANN TALGRLPRPA GYPSTVSTVE
1810 1820 1830 1840 1850
GHGPPLSPAI RVQEVAWKLS SNRCHSRESQ AAMAGQEETS QDETYEVKMN
1860 1870 1880 1890 1900
HDTEACSEPS LLSTEMLSYQ DDENRQLTLP EEDKRDIRQS PKRGFLRSAS
1910 1920 1930 1940 1950
LGRRASFHLE CLKRQKDRGG DISQKTVLPL HLVHHQALAV AGLSPLLQRS
1960 1970 1980 1990 2000
HSPASFPRPF ATPPATPGSR GWPPQPVPTL RLEGVESSEK LNSSFPSIHC
2010 2020 2030 2040 2050
GSWAETTPGG GGSSAARRVR PVSLMVPSQA GAPGRQFHGS ASSLVEAVLI
2060 2070 2080 2090 2100
SEGLGQFAQD PKFIEVTTQE LADACDMTIE EMESAADNIL SGGAPQSPNG
2110 2120 2130 2140
ALLPFVNCRD AGQDRAGGEE DAGCVRARGR PSEEELQDSR VYVSSL
Length:2,146
Mass (Da):240,292
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iAEAF038ED91C729C
Isoform 30 (identifier: Q13936-30) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.87
The sequence of this isoform differs from the canonical sequence as follows:
1297-1324: Missing.
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS
1010 1020 1030 1040 1050
LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG
1060 1070 1080 1090 1100
NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE
1110 1120 1130 1140 1150
VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE
1160 1170 1180 1190 1200
DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC
1210 1220 1230 1240 1250
ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL
1260 1270 1280 1290 1300
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKHYFC
1310 1320 1330 1340 1350
DAWNTFDALI VVGSIVDIAI TEVNPAEHTQ CSPSMNAEEN SRISITFFRL
1360 1370 1380 1390 1400
FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIVML FFIYAVIGMQ
1410 1420 1430 1440 1450
VFGKIALNDT TEINRNNNFQ TFPQAVLLLF RCATGEAWQD IMLACMPGKK
1460 1470 1480 1490 1500
CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL FVAVIMDNFD
1510 1520 1530 1540 1550
YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF
1560 1570 1580 1590 1600
GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ
1610 1620 1630 1640 1650
ANEELRAIIK KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK
1660 1670 1680 1690 1700
FKKRKEQGLV GKPSQRNALS LQAGLRTLHD IGPEIRRAIS GDLTAEEELD
1710 1720 1730 1740 1750
KAMKEAVSAA SEDDIFRRAG GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI
1760 1770 1780 1790 1800
NKAGSSQGDT ESPSHEKLVD STFTPSSYSS TGSNANINNA NNTALGRLPR
1810 1820 1830 1840 1850
PAGYPSTVST VEGHGPPLSP AIRVQEVAWK LSSNRCHSRE SQAAMAGQEE
1860 1870 1880 1890 1900
TSQDETYEVK MNHDTEACSE PSLLSTEMLS YQDDENRQLT LPEEDKRDIR
1910 1920 1930 1940 1950
QSPKRGFLRS ASLGRRASFH LECLKRQKDR GGDISQKTVL PLHLVHHQAL
1960 1970 1980 1990 2000
AVAGLSPLLQ RSHSPASFPR PFATPPATPG SRGWPPQPVP TLRLEGVESS
2010 2020 2030 2040 2050
EKLNSSFPSI HCGSWAETTP GGGGSSAARR VRPVSLMVPS QAGAPGRQFH
2060 2070 2080 2090 2100
GSASSLVEAV LISEGLGQFA QDPKFIEVTT QELADACDMT IEEMESAADN
2110 2120 2130 2140 2150
ILSGGAPQSP NGALLPFVNC RDAGQDRAGG EEDAGCVRAR GRPSEEELQD
SRVYVSSL
Length:2,158
Mass (Da):241,891
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iFB21849EC28ABB24
Isoform 31 (identifier: Q13936-31) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.88
The sequence of this isoform differs from the canonical sequence as follows:
952-971: Missing.
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL
1310 1320 1330 1340 1350
SETNHYFCDA WNTFDALIVV GSIVDIAITE VNPAEHTQCS PSMNAEENSR
1360 1370 1380 1390 1400
ISITFFRLFR VMRLVKLLSR GEGIRTLLWT FIKSFQALPY VALLIVMLFF
1410 1420 1430 1440 1450
IYAVIGMQVF GKIALNDTTE INRNNNFQTF PQAVLLLFRC ATGEAWQDIM
1460 1470 1480 1490 1500
LACMPGKKCA PESEPSNSTE GETPCGSSFA VFYFISFYML CAFLIINLFV
1510 1520 1530 1540 1550
AVIMDNFDYL TRDWSILGPH HLDEFKRIWA EYDPEAKGRI KHLDVVTLLR
1560 1570 1580 1590 1600
RIQPPLGFGK LCPHRVACKR LVSMNMPLNS DGTVMFNATL FALVRTALRI
1610 1620 1630 1640 1650
KTEGNLEQAN EELRAIIKKI WKRTSMKLLD QVVPPAGDDE VTVGKFYATF
1660 1670 1680 1690 1700
LIQEYFRKFK KRKEQGLVGK PSQRNALSLQ AGLRTLHDIG PEIRRAISGD
1710 1720 1730 1740 1750
LTAEEELDKA MKEAVSAASE DDIFRRAGGL FGNHVSYYQS DGRSAFPQTF
1760 1770 1780 1790 1800
TTQRPLHINK AGSSQGDTES PSHEKLVDST FTPSSYSSTG SNANINNANN
1810 1820 1830 1840 1850
TALGRLPRPA GYPSTVSTVE GHGPPLSPAI RVQEVAWKLS SNRCHSRESQ
1860 1870 1880 1890 1900
AAMAGQEETS QDETYEVKMN HDTEACSEPS LLSTEMLSYQ DDENRQLTLP
1910 1920 1930 1940 1950
EEDKRDIRQS PKRGFLRSAS LGRRASFHLE CLKRQKDRGG DISQKTVLPL
1960 1970 1980 1990 2000
HLVHHQALAV AGLSPLLQRS HSPASFPRPF ATPPATPGSR GWPPQPVPTL
2010 2020 2030 2040 2050
RLEGVESSEK LNSSFPSIHC GSWAETTPGG GGSSAARRVR PVSLMVPSQA
2060 2070 2080 2090 2100
GAPGRQFHGS ASSLVEAVLI SEGLGQFAQD PKFIEVTTQE LADACDMTIE
2110 2120 2130 2140 2150
EMESAADNIL SGGAPQSPNG ALLPFVNCRD AGQDRAGGEE DAGCVRARGR
2160
PSEEELQDSR VYVSSL
Length:2,166
Mass (Da):242,794
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i0929EBBC4916E1F2
Isoform 32 (identifier: Q13936-32) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.89
The sequence of this isoform differs from the canonical sequence as follows:
932-951: Missing.
1353-1363: Missing.
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL
1310 1320 1330 1340 1350
SETNHYFCDA WNTFDALIVV GSIVDIAITE VNNAEENSRI SITFFRLFRV
1360 1370 1380 1390 1400
MRLVKLLSRG EGIRTLLWTF IKSFQALPYV ALLIVMLFFI YAVIGMQVFG
1410 1420 1430 1440 1450
KIALNDTTEI NRNNNFQTFP QAVLLLFRCA TGEAWQDIML ACMPGKKCAP
1460 1470 1480 1490 1500
ESEPSNSTEG ETPCGSSFAV FYFISFYMLC AFLIINLFVA VIMDNFDYLT
1510 1520 1530 1540 1550
RDWSILGPHH LDEFKRIWAE YDPEAKGRIK HLDVVTLLRR IQPPLGFGKL
1560 1570 1580 1590 1600
CPHRVACKRL VSMNMPLNSD GTVMFNATLF ALVRTALRIK TEGNLEQANE
1610 1620 1630 1640 1650
ELRAIIKKIW KRTSMKLLDQ VVPPAGDDEV TVGKFYATFL IQEYFRKFKK
1660 1670 1680 1690 1700
RKEQGLVGKP SQRNALSLQA GLRTLHDIGP EIRRAISGDL TAEEELDKAM
1710 1720 1730 1740 1750
KEAVSAASED DIFRRAGGLF GNHVSYYQSD GRSAFPQTFT TQRPLHINKA
1760 1770 1780 1790 1800
GSSQGDTESP SHEKLVDSTF TPSSYSSTGS NANINNANNT ALGRLPRPAG
1810 1820 1830 1840 1850
YPSTVSTVEG HGPPLSPAIR VQEVAWKLSS NRCHSRESQA AMAGQEETSQ
1860 1870 1880 1890 1900
DETYEVKMNH DTEACSEPSL LSTEMLSYQD DENRQLTLPE EDKRDIRQSP
1910 1920 1930 1940 1950
KRGFLRSASL GRRASFHLEC LKRQKDRGGD ISQKTVLPLH LVHHQALAVA
1960 1970 1980 1990 2000
GLSPLLQRSH SPASFPRPFA TPPATPGSRG WPPQPVPTLR LEGVESSEKL
2010 2020 2030 2040 2050
NSSFPSIHCG SWAETTPGGG GSSAARRVRP VSLMVPSQAG APGRQFHGSA
2060 2070 2080 2090 2100
SSLVEAVLIS EGLGQFAQDP KFIEVTTQEL ADACDMTIEE MESAADNILS
2110 2120 2130 2140 2150
GGAPQSPNGA LLPFVNCRDA GQDRAGGEED AGCVRARGRP SEEELQDSRV
YVSSL
Length:2,155
Mass (Da):241,488
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iF62ACB4D54FC4180
Isoform 33 (identifier: Q13936-33) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: Alpha-1C.85
The sequence of this isoform differs from the canonical sequence as follows:
932-951: Missing.
1297-1324: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI
1310 1320 1330 1340 1350
TEVNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL
1610 1620 1630 1640 1650
LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS
1660 1670 1680 1690 1700
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG
1710 1720 1730 1740 1750
GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI NKAGSSQGDT ESPSHEKLVD
1760 1770 1780 1790 1800
STFTPSSYSS TGSNANINNA NNTALGRLPR PAGYPSTVST VEGHGPPLSP
1810 1820 1830 1840 1850
AIRVQEVAWK LSSNRERHVP MCEDLELRRD SGSAGTQAHC LLLRKANPSR
1860 1870 1880 1890 1900
CHSRESQAAM AGQEETSQDE TYEVKMNHDT EACSEPSLLS TEMLSYQDDE
1910 1920 1930 1940 1950
NRQLTLPEED KRDIRQSPKR GFLRSASLGR RASFHLECLK RQKDRGGDIS
1960 1970 1980 1990 2000
QKTVLPLHLV HHQALAVAGL SPLLQRSHSP ASFPRPFATP PATPGSRGWP
2010 2020 2030 2040 2050
PQPVPTLRLE GVESSEKLNS SFPSIHCGSW AETTPGGGGS SAARRVRPVS
2060 2070 2080 2090 2100
LMVPSQAGAP GRQFHGSASS LVEAVLISEG LGQFAQDPKF IEVTTQELAD
2110 2120 2130 2140 2150
ACDMTIEEME SAADNILSGG APQSPNGALL PFVNCRDAGQ DRAGGEEDAG
2160 2170
CVRARGRPSE EELQDSRVYV SSL
Length:2,173
Mass (Da):243,430
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iEA4530716379E381
Isoform 34 (identifier: Q13936-34) [UniParc]FASTAAdd to basketAdded to basket
Also known as: Alpha-1C,long-NT
The sequence of this isoform differs from the canonical sequence as follows:
1-16: MVNENTRMYIPEENHQ → MLRAFVQPGTPAYQPLPSHLSANTEVKFKGTLVHEAQLNYFYISPG
10 20 30 40 50
MLRAFVQPGT PAYQPLPSHL SANTEVKFKG TLVHEAQLNY FYISPGGSNY
60 70 80 90 100
GSPRPAHANM NANAAAGLAP EHIPTPGAAL SWQAAIDAAR QAKLMGSAGN
110 120 130 140 150
ATISTVSSTQ RKRQQYGKPK KQGSTTATRP PRALLCLTLK NPIRRACISI
160 170 180 190 200
VEWKPFEIII LLTIFANCVA LAIYIPFPED DSNATNSNLE RVEYLFLIIF
210 220 230 240 250
TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA ILEQATKADG
260 270 280 290 300
ANALGGKGAG FDVKALRAFR VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH
310 320 330 340 350
IALLVLFVII IYAIIGLELF MGKMHKTCYN QEGIADVPAE DDPSPCALET
360 370 380 390 400
GHGRQCQNGT VCKPGWDGPK HGITNFDNFA FAMLTVFQCI TMEGWTDVLY
410 420 430 440 450
WVNDAVGRDW PWIYFVTLII IGSFFVLNLV LGVLSGEFSK EREKAKARGD
460 470 480 490 500
FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEDEGMDEEK PRNMSMPTSE
510 520 530 540 550
TESVNTENVA GGDIEGENCG ARLAHRISKS KFSRYWRRWN RFCRRKCRAA
560 570 580 590 600
VKSNVFYWLV IFLVFLNTLT IASEHYNQPN WLTEVQDTAN KALLALFTAE
610 620 630 640 650
MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI LETILVETKI MSPLGISVLR
660 670 680 690 700
CVRLLRIFKI TRYWNSLSNL VASLLNSVRS IASLLLLLFL FIIIFSLLGM
710 720 730 740 750
QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF QILTGEDWNS VMYDGIMAYG
760 770 780 790 800
GPSFPGMLVC IYFIILFICG NYILLNVFLA IAVDNLADAE SLTSAQKEEE
810 820 830 840 850
EEKERKKLAR TASPEKKQEL VEKPAVGESK EEKIELKSIT ADGESPPATK
860 870 880 890 900
INMDDLQPNE NEDKSPYPNP ETTGEEDEEE PEMPVGPRPR PLSELHLKEK
910 920 930 940 950
AVPMPEASAF FIFSSNNRFR LQCHRIVNDT IFTNLILFFI LLSSISLAAE
960 970 980 990 1000
DPVQHTSFRN HILFYFDIVF TTIFTIEIAL KILGNADYVF TSIFTLEIIL
1010 1020 1030 1040 1050
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1060 1070 1080 1090 1100
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1110 1120 1130 1140 1150
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1160 1170 1180 1190 1200
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1210 1220 1230 1240 1250
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1260 1270 1280 1290 1300
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1310 1320 1330 1340 1350
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL
1360 1370 1380 1390 1400
SETNHYFCDA WNTFDALIVV GSIVDIAITE VNPAEHTQCS PSMNAEENSR
1410 1420 1430 1440 1450
ISITFFRLFR VMRLVKLLSR GEGIRTLLWT FIKSFQALPY VALLIVMLFF
1460 1470 1480 1490 1500
IYAVIGMQVF GKIALNDTTE INRNNNFQTF PQAVLLLFRC ATGEAWQDIM
1510 1520 1530 1540 1550
LACMPGKKCA PESEPSNSTE GETPCGSSFA VFYFISFYML CAFLIINLFV
1560 1570 1580 1590 1600
AVIMDNFDYL TRDWSILGPH HLDEFKRIWA EYDPEAKGRI KHLDVVTLLR
1610 1620 1630 1640 1650
RIQPPLGFGK LCPHRVACKR LVSMNMPLNS DGTVMFNATL FALVRTALRI
1660 1670 1680 1690 1700
KTEGNLEQAN EELRAIIKKI WKRTSMKLLD QVVPPAGDDE VTVGKFYATF
1710 1720 1730 1740 1750
LIQEYFRKFK KRKEQGLVGK PSQRNALSLQ AGLRTLHDIG PEIRRAISGD
1760 1770 1780 1790 1800
LTAEEELDKA MKEAVSAASE DDIFRRAGGL FGNHVSYYQS DGRSAFPQTF
1810 1820 1830 1840 1850
TTQRPLHINK AGSSQGDTES PSHEKLVDST FTPSSYSSTG SNANINNANN
1860 1870 1880 1890 1900
TALGRLPRPA GYPSTVSTVE GHGPPLSPAI RVQEVAWKLS SNRERHVPMC
1910 1920 1930 1940 1950
EDLELRRDSG SAGTQAHCLL LRKANPSRCH SRESQAAMAG QEETSQDETY
1960 1970 1980 1990 2000
EVKMNHDTEA CSEPSLLSTE MLSYQDDENR QLTLPEEDKR DIRQSPKRGF
2010 2020 2030 2040 2050
LRSASLGRRA SFHLECLKRQ KDRGGDISQK TVLPLHLVHH QALAVAGLSP
2060 2070 2080 2090 2100
LLQRSHSPAS FPRPFATPPA TPGSRGWPPQ PVPTLRLEGV ESSEKLNSSF
2110 2120 2130 2140 2150
PSIHCGSWAE TTPGGGGSSA ARRVRPVSLM VPSQAGAPGR QFHGSASSLV
2160 2170 2180 2190 2200
EAVLISEGLG QFAQDPKFIE VTTQELADAC DMTIEEMESA ADNILSGGAP
2210 2220 2230 2240 2250
QSPNGALLPF VNCRDAGQDR AGGEEDAGCV RARGRPSEEE LQDSRVYVSS
L
Note: Enhanced by PKC activator.
Show »Length:2,251
Mass (Da):252,091
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i2A9D55B23A501120
Isoform 35 (identifier: Q13936-35) [UniParc]FASTAAdd to basketAdded to basketShow »
The sequence of this isoform differs from the canonical sequence as follows:
306-308: Missing.
952-971: Missing.
1325-1352: Missing.
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIAAEDDP SPCALETGHG RQCQNGTVCK PGWDGPKHGI TNFDNFAFAM
360 370 380 390 400
LTVFQCITME GWTDVLYWVN DAVGRDWPWI YFVTLIIIGS FFVLNLVLGV
410 420 430 440 450
LSGEFSKERE KAKARGDFQK LREKQQLEED LKGYLDWITQ AEDIDPENED
460 470 480 490 500
EGMDEEKPRN MSMPTSETES VNTENVAGGD IEGENCGARL AHRISKSKFS
510 520 530 540 550
RYWRRWNRFC RRKCRAAVKS NVFYWLVIFL VFLNTLTIAS EHYNQPNWLT
560 570 580 590 600
EVQDTANKAL LALFTAEMLL KMYSLGLQAY FVSLFNRFDC FVVCGGILET
610 620 630 640 650
ILVETKIMSP LGISVLRCVR LLRIFKITRY WNSLSNLVAS LLNSVRSIAS
660 670 680 690 700
LLLLLFLFII IFSLLGMQLF GGKFNFDEMQ TRRSTFDNFP QSLLTVFQIL
710 720 730 740 750
TGEDWNSVMY DGIMAYGGPS FPGMLVCIYF IILFICGNYI LLNVFLAIAV
760 770 780 790 800
DNLADAESLT SAQKEEEEEK ERKKLARTAS PEKKQELVEK PAVGESKEEK
810 820 830 840 850
IELKSITADG ESPPATKINM DDLQPNENED KSPYPNPETT GEEDEEEPEM
860 870 880 890 900
PVGPRPRPLS ELHLKEKAVP MPEASAFFIF SSNNRFRLQC HRIVNDTIFT
910 920 930 940 950
NLILFFILLS SISLAAEDPV QHTSFRNHIL FYFDIVFTTI FTIEIALKMT
960 970 980 990 1000
AYGAFLHKGS FCRNYFNILD LLVVSVSLIS FGIQSSAINV VKILRVLRVL
1010 1020 1030 1040 1050
RPLRAINRAK GLKHVVQCVF VAIRTIGNIV IVTTLLQFMF ACIGVQLFKG
1060 1070 1080 1090 1100
KLYTCSDSSK QTEAECKGNY ITYKDGEVDH PIIQPRSWEN SKFDFDNVLA
1110 1120 1130 1140 1150
AMMALFTVST FEGWPELLYR SIDSHTEDKG PIYNYRVEIS IFFIIYIIII
1160 1170 1180 1190 1200
AFFMMNIFVG FVIVTFQEQG EQEYKNCELD KNQRQCVEYA LKARPLRRYI
1210 1220 1230 1240 1250
PKNQHQYKVW YVVNSTYFEY LMFVLILLNT ICLAMQHYGQ SCLFKIAMNI
1260 1270 1280 1290 1300
LNMLFTGLFT VEMILKLIAF KPKGYFSDPW NVFDFLIVIG SIIDVILSET
1310 1320 1330 1340 1350
NPAEHTQCSP SMNAEENSRI SITFFRLFRV MRLVKLLSRG EGIRTLLWTF
1360 1370 1380 1390 1400
IKSFQALPYV ALLIVMLFFI YAVIGMQVFG KIALNDTTEI NRNNNFQTFP
1410 1420 1430 1440 1450
QAVLLLFRCA TGEAWQDIML ACMPGKKCAP ESEPSNSTEG ETPCGSSFAV
1460 1470 1480 1490 1500
FYFISFYMLC AFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFKRIWAE
1510 1520 1530 1540 1550
YDPEAKGRIK HLDVVTLLRR IQPPLGFGKL CPHRVACKRL VSMNMPLNSD
1560 1570 1580 1590 1600
GTVMFNATLF ALVRTALRIK TEGNLEQANE ELRAIIKKIW KRTSMKLLDQ
1610 1620 1630 1640 1650
VVPPAGDDEV TVGKFYATFL IQEYFRKFKK RKEQGLVGKP SQRNALSLQA
1660 1670 1680 1690 1700
GLRTLHDIGP EIRRAISGDL TAEEELDKAM KEAVSAASED DIFRRAGGLF
1710 1720 1730 1740 1750
GNHVSYYQSD GRSAFPQTFT TQRPLHINKA GSSQGDTESP SHEKLVDSTF
1760 1770 1780 1790 1800
TPSSYSSTGS NANINNANNT ALGRLPRPAG YPSTVSTVEG HGPPLSPAIR
1810 1820 1830 1840 1850
VQEVAWKLSS NRCHSRESQA AMAGQEETSQ DETYEVKMNH DTEACSEPSL
1860 1870 1880 1890 1900
LSTEMLSYQD DENRQLTLPE EDKRDIRQSP KRGFLRSASL GRRASFHLEC
1910 1920 1930 1940 1950
LKRQKDRGGD ISQKTVLPLH LVHHQALAVA GLSPLLQRSH SPASFPRPFA
1960 1970 1980 1990 2000
TPPATPGSRG WPPQPVPTLR LEGVESSEKL NSSFPSIHCG SWAETTPGGG
2010 2020 2030 2040 2050
GSSAARRVRP VSLMVPSQAG APGRQFHGSA SSLVEAVLIS EGLGQFAQDP
2060 2070 2080 2090 2100
KFIEVTTQEL ADACDMTIEE MESAADNILS GGAPQSPNGA LLPFVNCRDA
2110 2120 2130
GQDRAGGEED AGCVRARGRP SEEELQDSRV YVSSL
Length:2,135
Mass (Da):239,375
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iFB695F875A7F2449
Isoform 36 (identifier: Q13936-36) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
372-391: VNDAVGRDWPWIYFVTLIII → MQDAMGYELPWVYFVSLVIF
952-971: Missing.
1325-1352: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI FGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL
1310 1320 1330 1340 1350
SETNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL
1610 1620 1630 1640 1650
LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS
1660 1670 1680 1690 1700
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG
1710 1720 1730 1740 1750
GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI NKAGSSQGDT ESPSHEKLVD
1760 1770 1780 1790 1800
STFTPSSYSS TGSNANINNA NNTALGRLPR PAGYPSTVST VEGHGPPLSP
1810 1820 1830 1840 1850
AIRVQEVAWK LSSNRERHVP MCEDLELRRD SGSAGTQAHC LLLRKANPSR
1860 1870 1880 1890 1900
CHSRESQAAM AGQEETSQDE TYEVKMNHDT EACSEPSLLS TEMLSYQDDE
1910 1920 1930 1940 1950
NRQLTLPEED KRDIRQSPKR GFLRSASLGR RASFHLECLK RQKDRGGDIS
1960 1970 1980 1990 2000
QKTVLPLHLV HHQALAVAGL SPLLQRSHSP ASFPRPFATP PATPGSRGWP
2010 2020 2030 2040 2050
PQPVPTLRLE GVESSEKLNS SFPSIHCGSW AETTPGGGGS SAARRVRPVS
2060 2070 2080 2090 2100
LMVPSQAGAP GRQFHGSASS LVEAVLISEG LGQFAQDPKF IEVTTQELAD
2110 2120 2130 2140 2150
ACDMTIEEME SAADNILSGG APQSPNGALL PFVNCRDAGQ DRAGGEEDAG
2160 2170
CVRARGRPSE EELQDSRVYV SSL
Note: Gene prediction based on EST data.
Show »Length:2,173
Mass (Da):243,633
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i4819FD32FA521438
Isoform 37 (identifier: Q13936-37) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
372-391: VNDAVGRDWPWIYFVTLIII → MQDAMGYELPWVYFVSLVIF
952-971: Missing.
1325-1352: Missing.
1864-1898: Missing.
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI FGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPN
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFVVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEL VEKPAVGESK
810 820 830 840 850
EEKIELKSIT ADGESPPATK INMDDLQPNE NEDKSPYPNP ETTGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSSNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILFYFDIVF TTIFTIEIAL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL
1310 1320 1330 1340 1350
SETNPAEHTQ CSPSMNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL
1610 1620 1630 1640 1650
LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS
1660 1670 1680 1690 1700
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG
1710 1720 1730 1740 1750
GLFGNHVSYY QSDGRSAFPQ TFTTQRPLHI NKAGSSQGDT ESPSHEKLVD
1760 1770 1780 1790 1800
STFTPSSYSS TGSNANINNA NNTALGRLPR PAGYPSTVST VEGHGPPLSP
1810 1820 1830 1840 1850
AIRVQEVAWK LSSNRCHSRE SQAAMAGQEE TSQDETYEVK MNHDTEACSE
1860 1870 1880 1890 1900
PSLLSTEMLS YQDDENRQLT LPEEDKRDIR QSPKRGFLRS ASLGRRASFH
1910 1920 1930 1940 1950
LECLKRQKDR GGDISQKTVL PLHLVHHQAL AVAGLSPLLQ RSHSPASFPR
1960 1970 1980 1990 2000
PFATPPATPG SRGWPPQPVP TLRLEGVESS EKLNSSFPSI HCGSWAETTP
2010 2020 2030 2040 2050
GGGGSSAARR VRPVSLMVPS QAGAPGRQFH GSASSLVEAV LISEGLGQFA
2060 2070 2080 2090 2100
QDPKFIEVTT QELADACDMT IEEMESAADN ILSGGAPQSP NGALLPFVNC
2110 2120 2130
RDAGQDRAGG EEDAGCVRAR GRPSEEELQD SRVYVSSL
Note: Gene prediction based on EST data.
Show »Length:2,138
Mass (Da):239,704
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i2881D49EB0831097
<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
|---|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1072 | K → Q in Z26272 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1157 | N → K in AAA58409 (PubMed:1653763).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1244 | L → P in AAA74590 (PubMed:1335957).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1384 | L → P in AAA74590 (PubMed:1335957).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1412 | A → V in AAI46847 (PubMed:15489334).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1459 | R → K in CAA81219 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84340 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84341 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84342 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84343 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84344 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84345 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84346 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84347 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84348 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84349 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84350 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA84351 (PubMed:7959794).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in CAA12174 (PubMed:9607315).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in AAX37354 (PubMed:17071743).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in AAX37355 (PubMed:17071743).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → A in AAX37356 (PubMed:17071743).Curated | 1 | ||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 2205 | R → G in AAA17030 (PubMed:1316612).Curated | 1 | ||
| Isoform 26 (identifier: Q13936-26) | |||||
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1573 | A → T in CAA84348 (PubMed:7959794). | 1 | ||
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075148 | 28 | A → T in TS; only with cardiac manifestation; unknown pathological significance; increased channel activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075149 | 37 | G → R Polymorphism. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044039 | 39 | A → V in BRGDA3; unknown pathological significance; affects channel activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_045987 | 84 | Q → R3 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
|