Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 160 (13 Feb 2019)
Sequence version 3 (30 May 2006)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Bystin

Gene

BYSL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.2 Publications

Miscellaneous

HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S ribosomal subunit. HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bystin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BYSL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112578.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1157 BYSL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603871 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13895

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
705

Open Targets

More...
OpenTargetsi
ENSG00000112578

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25472

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BYSL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
108884834

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001861141 – 437BystinAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40Omega-N-methylarginineCombined sources1
Modified residuei55PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei156PhosphothreonineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13895

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13895

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13895

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13895

PeptideAtlas

More...
PeptideAtlasi
Q13895

PRoteomics IDEntifications database

More...
PRIDEi
Q13895

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59718

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q13895

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13895

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13895

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q13895

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112578 Expressed in 148 organ(s), highest expression level in left coronary artery

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13895 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13895 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031217
HPA031219

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds trophinin, tastin and cytokeratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081175EBI-358049,EBI-717810
AESQ08117-24EBI-358049,EBI-11741437
AIMP2Q131555EBI-358049,EBI-745226
BEND7Q8N7W2-27EBI-358049,EBI-10181188
C1orf94Q6P1W53EBI-358049,EBI-946029
CCDC102BQ68D865EBI-358049,EBI-10171570
CCDC136Q96JN2-25EBI-358049,EBI-10171416
CDC23Q9UJX25EBI-358049,EBI-396137
CDCA7LQ96GN55EBI-358049,EBI-5278764
CEP44Q9C0F15EBI-358049,EBI-744115
CEP57L1Q8IYX8-25EBI-358049,EBI-10181988
CEP70Q8NHQ17EBI-358049,EBI-739624
COILP3843210EBI-358049,EBI-945751
DDX17Q928415EBI-358049,EBI-746012
DOCK8Q8NF50-25EBI-358049,EBI-10174653
EMDP504023EBI-358049,EBI-489887
EPS8Q129293EBI-358049,EBI-375576
ERBB4Q153033EBI-358049,EBI-80371
FAM9BQ8IZU05EBI-358049,EBI-10175124
FLJ13057Q53SE73EBI-358049,EBI-10172181
FXR2P511167EBI-358049,EBI-740459
GMCL1Q96IK54EBI-358049,EBI-2548508
GOLGA2Q083797EBI-358049,EBI-618309
HMBOX1Q6NT767EBI-358049,EBI-2549423
IKZF1Q134225EBI-358049,EBI-745305
KRT31Q153233EBI-358049,EBI-948001
KRT40Q6A1627EBI-358049,EBI-10171697
KRTAP10-5P603705EBI-358049,EBI-10172150
KRTAP10-7P604095EBI-358049,EBI-10172290
KRTAP4-2Q9BYR53EBI-358049,EBI-10172511
L3MBTL3Q96JM75EBI-358049,EBI-2686809
LONRF1Q17RB87EBI-358049,EBI-2341787
LTV1Q96GA37EBI-358049,EBI-2558389
LZTS2Q9BRK45EBI-358049,EBI-741037
MID1O153443EBI-358049,EBI-2340316
MID2Q9UJV3-27EBI-358049,EBI-10172526
MIPOL1Q8TD107EBI-358049,EBI-2548751
MRFAP1L1Q96HT812EBI-358049,EBI-748896
MTUS2Q5JR595EBI-358049,EBI-742948
NECAB2Q7Z6G3-25EBI-358049,EBI-10172876
OLIG3Q7RTU35EBI-358049,EBI-10225049
PDE4DIPQ5VU435EBI-358049,EBI-1105124
PHC2Q8IXK06EBI-358049,EBI-713786
PNMA1Q8ND903EBI-358049,EBI-302345
PNMA2Q9UL425EBI-358049,EBI-302355
RALYLQ86SE53EBI-358049,EBI-741520
SMN2Q166377EBI-358049,EBI-395421
SSX2IPQ9Y2D85EBI-358049,EBI-2212028
STX11O755587EBI-358049,EBI-714135
TEKT1Q969V45EBI-358049,EBI-10180409
THAP1Q9NVV97EBI-358049,EBI-741515
TNIP1Q150257EBI-358049,EBI-357849
TRAF4Q9BUZ48EBI-358049,EBI-3650647
TRIM27P143735EBI-358049,EBI-719493
TRIM37O949728EBI-358049,EBI-741602
TRIM54Q9BYV26EBI-358049,EBI-2130429
TRIP6Q156546EBI-358049,EBI-742327
TROQ128164EBI-358049,EBI-950001
TROAPQ128159EBI-358049,EBI-2349743
UBE2HA4D1L53EBI-358049,EBI-10230777
VPS37BQ9H9H47EBI-358049,EBI-4400866
ZBTB14O438297EBI-358049,EBI-10176632
ZBTB8AQ96BR97EBI-358049,EBI-742740
ZFP64Q9NTW75EBI-358049,EBI-745730

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107167, 131 interactors

Database of interacting proteins

More...
DIPi
DIP-50092N

Protein interaction database and analysis system

More...
IntActi
Q13895, 153 interactors

Molecular INTeraction database

More...
MINTi
Q13895

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000230340

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G18electron microscopy3.60w1-437[»]
6G4Selectron microscopy4.00w1-437[»]
6G4Welectron microscopy4.50w1-437[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q13895

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13895

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bystin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3871 Eukaryota
ENOG410XPH5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007241

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000178028

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG024425

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13895

KEGG Orthology (KO)

More...
KOi
K14797

Identification of Orthologs from Complete Genome Data

More...
OMAi
IAEMDYT

Database of Orthologous Groups

More...
OrthoDBi
1193442at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13895

TreeFam database of animal gene trees

More...
TreeFami
TF312968

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007955 Bystin

The PANTHER Classification System

More...
PANTHERi
PTHR12821 PTHR12821, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05291 Bystin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q13895-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKFKAARGV GGQEKHAPLA DQILAGNAVR AGVREKRRGR GTGEAEEEYV
60 70 80 90 100
GPRLSRRILQ QARQQQEELE AEHGTGDKPA APRERTTRLG PRMPQDGSDD
110 120 130 140 150
EDEEWPTLEK AATMTAAGHH AEVVVDPEDE RAIEMFMNKN PPARRTLADI
160 170 180 190 200
IMEKLTEKQT EVETVMSEVS GFPMPQLDPR VLEVYRGVRE VLSKYRSGKL
210 220 230 240 250
PKAFKIIPAL SNWEQILYVT EPEAWTAAAM YQATRIFASN LKERMAQRFY
260 270 280 290 300
NLVLLPRVRD DVAEYKRLNF HLYMALKKAL FKPGAWFKGI LIPLCESGTC
310 320 330 340 350
TLREAIIVGS IITKCSIPVL HSSAAMLKIA EMEYSGANSI FLRLLLDKKY
360 370 380 390 400
ALPYRVLDAL VFHFLGFRTE KRELPVLWHQ CLLTLVQRYK ADLATDQKEA
410 420 430
LLELLRLQPH PQLSPEIRRE LQSAVPRDVE DVPITVE
Length:437
Mass (Da):49,601
Last modified:May 30, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A8C5E5EB108DF1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBL2F8WBL2_HUMAN
Bystin
BYSL
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BY94H7BY94_HUMAN
Bystin
BYSL
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC16603 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti214E → D in AAH07340 (PubMed:15489334).Curated1
Sequence conflicti263A → G in AAC16603 (PubMed:9560222).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033641103E → K. Corresponds to variant dbSNP:rs2296916Ensembl.1
Natural variantiVAR_048439426P → S. Corresponds to variant dbSNP:rs3828855Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC007340 mRNA Translation: AAH07340.3
BC050645 mRNA Translation: AAH50645.1
BC062627 mRNA Translation: AAH62627.2
L36720 mRNA Translation: AAC16603.2 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34450.1

NCBI Reference Sequences

More...
RefSeqi
NP_004044.3, NM_004053.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.106880

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000230340; ENSP00000230340; ENSG00000112578

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
705

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:705

UCSC genome browser

More...
UCSCi
uc003orl.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007340 mRNA Translation: AAH07340.3
BC050645 mRNA Translation: AAH50645.1
BC062627 mRNA Translation: AAH62627.2
L36720 mRNA Translation: AAC16603.2 Different initiation.
CCDSiCCDS34450.1
RefSeqiNP_004044.3, NM_004053.3
UniGeneiHs.106880

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G18electron microscopy3.60w1-437[»]
6G4Selectron microscopy4.00w1-437[»]
6G4Welectron microscopy4.50w1-437[»]
ProteinModelPortaliQ13895
SMRiQ13895
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107167, 131 interactors
DIPiDIP-50092N
IntActiQ13895, 153 interactors
MINTiQ13895
STRINGi9606.ENSP00000230340

PTM databases

iPTMnetiQ13895
PhosphoSitePlusiQ13895
SwissPalmiQ13895

Polymorphism and mutation databases

BioMutaiBYSL
DMDMi108884834

2D gel databases

SWISS-2DPAGEiQ13895

Proteomic databases

EPDiQ13895
jPOSTiQ13895
MaxQBiQ13895
PaxDbiQ13895
PeptideAtlasiQ13895
PRIDEiQ13895
ProteomicsDBi59718

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
705
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230340; ENSP00000230340; ENSG00000112578
GeneIDi705
KEGGihsa:705
UCSCiuc003orl.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
705
DisGeNETi705
EuPathDBiHostDB:ENSG00000112578.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BYSL
HGNCiHGNC:1157 BYSL
HPAiHPA031217
HPA031219
MIMi603871 gene
neXtProtiNX_Q13895
OpenTargetsiENSG00000112578
PharmGKBiPA25472

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3871 Eukaryota
ENOG410XPH5 LUCA
GeneTreeiENSGT00390000007241
HOGENOMiHOG000178028
HOVERGENiHBG024425
InParanoidiQ13895
KOiK14797
OMAiIAEMDYT
OrthoDBi1193442at2759
PhylomeDBiQ13895
TreeFamiTF312968

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BYSL human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BYSL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
705

Protein Ontology

More...
PROi
PR:Q13895

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112578 Expressed in 148 organ(s), highest expression level in left coronary artery
ExpressionAtlasiQ13895 baseline and differential
GenevisibleiQ13895 HS

Family and domain databases

InterProiView protein in InterPro
IPR007955 Bystin
PANTHERiPTHR12821 PTHR12821, 1 hit
PfamiView protein in Pfam
PF05291 Bystin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBYST_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13895
Secondary accession number(s): Q6P5W4, Q86W44, Q96IP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 30, 2006
Last modified: February 13, 2019
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again