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Protein

Bystin

Gene

BYSL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.2 Publications

Miscellaneous

HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S ribosomal subunit. HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell proliferation Source: Ensembl
  • female pregnancy Source: ProtInc
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: Ensembl
  • trophectodermal cell differentiation Source: Ensembl

Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Bystin
Gene namesi
Name:BYSL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112578.9
HGNCiHGNC:1157 BYSL
MIMi603871 gene
neXtProtiNX_Q13895

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi705
OpenTargetsiENSG00000112578
PharmGKBiPA25472

Polymorphism and mutation databases

BioMutaiBYSL
DMDMi108884834

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861141 – 437BystinAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40Omega-N-methylarginineCombined sources1
Modified residuei55PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei156PhosphothreonineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ13895
MaxQBiQ13895
PaxDbiQ13895
PeptideAtlasiQ13895
PRIDEiQ13895
ProteomicsDBi59718

2D gel databases

SWISS-2DPAGEiQ13895

PTM databases

iPTMnetiQ13895
PhosphoSitePlusiQ13895
SwissPalmiQ13895

Expressioni

Tissue specificityi

Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi.

Gene expression databases

BgeeiENSG00000112578
CleanExiHS_BYSL
ExpressionAtlasiQ13895 baseline and differential
GenevisibleiQ13895 HS

Organism-specific databases

HPAiHPA031217
HPA031219

Interactioni

Subunit structurei

Binds trophinin, tastin and cytokeratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081175EBI-358049,EBI-717810
AESQ08117-24EBI-358049,EBI-11741437
AIMP2Q131555EBI-358049,EBI-745226
BEND7Q8N7W2-27EBI-358049,EBI-10181188
C1orf94Q6P1W53EBI-358049,EBI-946029
CCDC102BQ68D865EBI-358049,EBI-10171570
CCDC136Q96JN2-25EBI-358049,EBI-10171416
CDC23Q9UJX25EBI-358049,EBI-396137
CDCA7LQ96GN55EBI-358049,EBI-5278764
CEP44Q9C0F15EBI-358049,EBI-744115
CEP57L1Q8IYX8-25EBI-358049,EBI-10181988
CEP70Q8NHQ17EBI-358049,EBI-739624
COILP3843210EBI-358049,EBI-945751
DDX17Q928415EBI-358049,EBI-746012
DOCK8Q8NF50-25EBI-358049,EBI-10174653
EMDP504023EBI-358049,EBI-489887
EPS8Q129293EBI-358049,EBI-375576
ERBB4Q153033EBI-358049,EBI-80371
FAM9BQ8IZU05EBI-358049,EBI-10175124
FLJ13057Q53SE73EBI-358049,EBI-10172181
FXR2P511167EBI-358049,EBI-740459
GMCL1Q96IK54EBI-358049,EBI-2548508
GOLGA2Q083797EBI-358049,EBI-618309
HMBOX1Q6NT767EBI-358049,EBI-2549423
IKZF1Q134225EBI-358049,EBI-745305
KRT31Q153233EBI-358049,EBI-948001
KRT40Q6A1627EBI-358049,EBI-10171697
KRTAP10-5P603705EBI-358049,EBI-10172150
KRTAP10-7P604095EBI-358049,EBI-10172290
KRTAP4-2Q9BYR53EBI-358049,EBI-10172511
L3MBTL3Q96JM75EBI-358049,EBI-2686809
LONRF1Q17RB87EBI-358049,EBI-2341787
LTV1Q96GA37EBI-358049,EBI-2558389
LZTS2Q9BRK45EBI-358049,EBI-741037
MID1O153443EBI-358049,EBI-2340316
MID2Q9UJV3-27EBI-358049,EBI-10172526
MIPOL1Q8TD107EBI-358049,EBI-2548751
MRFAP1L1Q96HT812EBI-358049,EBI-748896
MTUS2Q5JR595EBI-358049,EBI-742948
NECAB2Q7Z6G3-25EBI-358049,EBI-10172876
OLIG3Q7RTU35EBI-358049,EBI-10225049
PDE4DIPQ5VU435EBI-358049,EBI-1105124
PHC2Q8IXK06EBI-358049,EBI-713786
PNMA1Q8ND903EBI-358049,EBI-302345
PNMA2Q9UL425EBI-358049,EBI-302355
RALYLQ86SE53EBI-358049,EBI-741520
SMN2Q166377EBI-358049,EBI-395421
SSX2IPQ9Y2D85EBI-358049,EBI-2212028
STX11O755587EBI-358049,EBI-714135
TEKT1Q969V45EBI-358049,EBI-10180409
THAP1Q9NVV97EBI-358049,EBI-741515
TNIP1Q150257EBI-358049,EBI-357849
TRAF4Q9BUZ48EBI-358049,EBI-3650647
TRIM27P143735EBI-358049,EBI-719493
TRIM37O949728EBI-358049,EBI-741602
TRIM54Q9BYV26EBI-358049,EBI-2130429
TRIP6Q156546EBI-358049,EBI-742327
TROQ128164EBI-358049,EBI-950001
TROAPQ128159EBI-358049,EBI-2349743
UBE2HA4D1L53EBI-358049,EBI-10230777
VPS37BQ9H9H47EBI-358049,EBI-4400866
ZBTB14O438297EBI-358049,EBI-10176632
ZBTB8AQ96BR97EBI-358049,EBI-742740
ZFP64Q9NTW75EBI-358049,EBI-745730

Protein-protein interaction databases

BioGridi107167, 124 interactors
DIPiDIP-50092N
IntActiQ13895, 153 interactors
MINTiQ13895
STRINGi9606.ENSP00000230340

Structurei

3D structure databases

ProteinModelPortaliQ13895
SMRiQ13895
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bystin family.Curated

Phylogenomic databases

eggNOGiKOG3871 Eukaryota
ENOG410XPH5 LUCA
GeneTreeiENSGT00390000007241
HOGENOMiHOG000178028
HOVERGENiHBG024425
InParanoidiQ13895
KOiK14797
OMAiNWEQILF
OrthoDBiEOG091G08JE
PhylomeDBiQ13895
TreeFamiTF312968

Family and domain databases

InterProiView protein in InterPro
IPR007955 Bystin
PANTHERiPTHR12821 PTHR12821, 1 hit
PfamiView protein in Pfam
PF05291 Bystin, 1 hit

Sequencei

Sequence statusi: Complete.

Q13895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFKAARGV GGQEKHAPLA DQILAGNAVR AGVREKRRGR GTGEAEEEYV
60 70 80 90 100
GPRLSRRILQ QARQQQEELE AEHGTGDKPA APRERTTRLG PRMPQDGSDD
110 120 130 140 150
EDEEWPTLEK AATMTAAGHH AEVVVDPEDE RAIEMFMNKN PPARRTLADI
160 170 180 190 200
IMEKLTEKQT EVETVMSEVS GFPMPQLDPR VLEVYRGVRE VLSKYRSGKL
210 220 230 240 250
PKAFKIIPAL SNWEQILYVT EPEAWTAAAM YQATRIFASN LKERMAQRFY
260 270 280 290 300
NLVLLPRVRD DVAEYKRLNF HLYMALKKAL FKPGAWFKGI LIPLCESGTC
310 320 330 340 350
TLREAIIVGS IITKCSIPVL HSSAAMLKIA EMEYSGANSI FLRLLLDKKY
360 370 380 390 400
ALPYRVLDAL VFHFLGFRTE KRELPVLWHQ CLLTLVQRYK ADLATDQKEA
410 420 430
LLELLRLQPH PQLSPEIRRE LQSAVPRDVE DVPITVE
Length:437
Mass (Da):49,601
Last modified:May 30, 2006 - v3
Checksum:i1A8C5E5EB108DF1A
GO

Sequence cautioni

The sequence AAC16603 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214E → D in AAH07340 (PubMed:15489334).Curated1
Sequence conflicti263A → G in AAC16603 (PubMed:9560222).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033641103E → K. Corresponds to variant dbSNP:rs2296916Ensembl.1
Natural variantiVAR_048439426P → S. Corresponds to variant dbSNP:rs3828855Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007340 mRNA Translation: AAH07340.3
BC050645 mRNA Translation: AAH50645.1
BC062627 mRNA Translation: AAH62627.2
L36720 mRNA Translation: AAC16603.2 Different initiation.
CCDSiCCDS34450.1
RefSeqiNP_004044.3, NM_004053.3
UniGeneiHs.106880

Genome annotation databases

EnsembliENST00000230340; ENSP00000230340; ENSG00000112578
GeneIDi705
KEGGihsa:705
UCSCiuc003orl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBYST_HUMAN
AccessioniPrimary (citable) accession number: Q13895
Secondary accession number(s): Q6P5W4, Q86W44, Q96IP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 30, 2006
Last modified: July 18, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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