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Entry version 169 (22 Apr 2020)
Sequence version 3 (30 May 2006)
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Protein

Bystin

Gene

BYSL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.2 Publications

Miscellaneous

HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S ribosomal subunit. HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BystinCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BYSLImported
Synonyms:ENP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:1157 BYSL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603871 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13895

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
705

Open Targets

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OpenTargetsi
ENSG00000112578

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25472

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q13895 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
BYSL

Domain mapping of disease mutations (DMDM)

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DMDMi
108884834

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001861141 – 437BystinAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40Omega-N-methylarginineCombined sources1
Modified residuei55PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei156PhosphothreonineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13895

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13895

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13895

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13895

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13895

PeptideAtlas

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PeptideAtlasi
Q13895

PRoteomics IDEntifications database

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PRIDEi
Q13895

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
59718

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
Q13895

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13895

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q13895

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13895

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q13895

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000112578 Expressed in left coronary artery and 147 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13895 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13895 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000112578 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds trophinin, tastin and cytokeratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q13895
With#Exp.IntAct
AIMP2 [Q13155]5EBI-358049,EBI-745226
AMOTL2 [Q9Y2J4]3EBI-358049,EBI-746752
ATP5F1B [P06576]3EBI-358049,EBI-356231
AXIN2 [Q9Y2T1]3EBI-358049,EBI-4400025
BEND7 - isoform 2 [Q8N7W2-2]8EBI-358049,EBI-10181188
BFSP1 - isoform 2 [Q12934-2]3EBI-358049,EBI-12123320
BHLHE40 [O14503]3EBI-358049,EBI-711810
C1orf94 [Q6P1W5]3EBI-358049,EBI-946029
CAPN3 - isoform IV [P20807-4]3EBI-358049,EBI-11532021
CASQ2 [O14958]3EBI-358049,EBI-6859557
CAVIN4 [Q5BKX8]3EBI-358049,EBI-12836558
CCDC102B [Q68D86]6EBI-358049,EBI-10171570
CCDC136 - isoform 2 [Q96JN2-2]5EBI-358049,EBI-10171416
CDC23 [Q9UJX2]5EBI-358049,EBI-396137
CDCA7L [Q96GN5]5EBI-358049,EBI-5278764
CEP44 [Q9C0F1]5EBI-358049,EBI-744115
CEP57L1 - isoform 2 [Q8IYX8-2]5EBI-358049,EBI-10181988
CEP70 [Q8NHQ1]8EBI-358049,EBI-739624
COIL [P38432]11EBI-358049,EBI-945751
DDX17 [Q92841]6EBI-358049,EBI-746012
DOCK8 - isoform 2 [Q8NF50-2]5EBI-358049,EBI-10174653
EAPP [Q56P03]3EBI-358049,EBI-748732
EMD [P50402]6EBI-358049,EBI-489887
EPS8 [Q12929]3EBI-358049,EBI-375576
ERBB4 [Q15303]3EBI-358049,EBI-80371
FAM228A [Q86W67]3EBI-358049,EBI-12958227
FAM9B [Q8IZU0]5EBI-358049,EBI-10175124
FCHO1 [A0A0C3SFZ9]3EBI-358049,EBI-11977403
FLJ13057 [Q53SE7]3EBI-358049,EBI-10172181
FXR1 - isoform 2 [P51114-2]3EBI-358049,EBI-11022345
FXR2 [P51116]8EBI-358049,EBI-740459
GAS8 [O95995]3EBI-358049,EBI-1052570
GMCL1 [Q96IK5]5EBI-358049,EBI-2548508
GOLGA2 [Q08379]8EBI-358049,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-358049,EBI-5916454
GRIPAP1 [Q4V328]3EBI-358049,EBI-717919
HMBOX1 [Q6NT76]8EBI-358049,EBI-2549423
HMG20A [Q9NP66]3EBI-358049,EBI-740641
HOOK2 - isoform 2 [Q96ED9-2]3EBI-358049,EBI-10961706
HSF2BP [O75031]3EBI-358049,EBI-7116203
IKZF1 [Q13422]5EBI-358049,EBI-745305
IKZF1 - isoform Ik7 [Q13422-7]3EBI-358049,EBI-11522367
IKZF3 [Q9UKT9]3EBI-358049,EBI-747204
JRK - isoform 2 [O75564-2]3EBI-358049,EBI-17181882
KATNAL1 [Q9BW62]3EBI-358049,EBI-743591
KIAA1328 [Q86T90]3EBI-358049,EBI-3437878
KIFC3 - isoform 4 [Q9BVG8-5]5EBI-358049,EBI-14069005
KLHL2 [O95198]3EBI-358049,EBI-746999
KLHL6 [Q8WZ60]3EBI-358049,EBI-6426464
KRT31 [Q15323]3EBI-358049,EBI-948001
KRT40 [Q6A162]8EBI-358049,EBI-10171697
KRTAP10-5 [P60370]5EBI-358049,EBI-10172150
KRTAP10-7 [P60409]5EBI-358049,EBI-10172290
KRTAP4-2 [Q9BYR5]3EBI-358049,EBI-10172511
L3MBTL3 [Q96JM7]5EBI-358049,EBI-2686809
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-358049,EBI-11985629
LDOC1 [O95751]4EBI-358049,EBI-740738
LHX3 - isoform B [Q9UBR4-2]3EBI-358049,EBI-12039345
LMO1 [P25800]3EBI-358049,EBI-8639312
LMO2 - isoform 3 [P25791-3]3EBI-358049,EBI-11959475
LONRF1 [Q17RB8]8EBI-358049,EBI-2341787
LTV1 [Q96GA3]11EBI-358049,EBI-2558389
LZTS1 [Q9Y250]3EBI-358049,EBI-1216080
LZTS2 [Q9BRK4]6EBI-358049,EBI-741037
MB21D2 [Q8IYB1]3EBI-358049,EBI-11323212
MCIDAS [D6RGH6]3EBI-358049,EBI-3954372
MEAF6 [Q9HAF1]3EBI-358049,EBI-399266
MEOX1 [P50221]3EBI-358049,EBI-2864512
MEOX2 [Q6FHY5]3EBI-358049,EBI-16439278
MID1 [O15344]4EBI-358049,EBI-2340316
MID2 - isoform 2 [Q9UJV3-2]8EBI-358049,EBI-10172526
MIPOL1 [Q8TD10]8EBI-358049,EBI-2548751
MKRN1 [Q9UHC7]3EBI-358049,EBI-373524
MPHOSPH10 [O00566]3EBI-358049,EBI-5235884
MRFAP1L1 [Q96HT8]13EBI-358049,EBI-748896
MSANTD4 [Q8NCY6]3EBI-358049,EBI-7850168
MTUS2 [Q5JR59]5EBI-358049,EBI-742948
MTUS2 - isoform 2 [Q5JR59-3]3EBI-358049,EBI-11522433
NECAB2 - isoform 2 [Q7Z6G3-2]6EBI-358049,EBI-10172876
NF2 - isoform 4 [P35240-4]3EBI-358049,EBI-1014514
OLIG3 [Q7RTU3]5EBI-358049,EBI-10225049
OSBPL3 [Q9H4L5]3EBI-358049,EBI-1051317
PDE4DIP [Q5VU43]5EBI-358049,EBI-1105124
PDE4DIP - isoform 2 [Q5VU43-2]3EBI-358049,EBI-9640281
PHC2 [Q8IXK0]6EBI-358049,EBI-713786
PICK1 [Q9NRD5]3EBI-358049,EBI-79165
PIH1D1 [Q9NWS0]3EBI-358049,EBI-357318
PNMA1 [Q8ND90]3EBI-358049,EBI-302345
PNMA2 [Q9UL42]7EBI-358049,EBI-302355
PRICKLE1 [Q96MT3]3EBI-358049,EBI-2348662
PSMC6 [P62333]3EBI-358049,EBI-357669
RACGAP1 [Q9H0H5]3EBI-358049,EBI-717233
RACK1 [P63244]3EBI-358049,EBI-296739
RALY [Q53GL6]3EBI-358049,EBI-9512693
RALYL [Q86SE5]3EBI-358049,EBI-741520
RBAK [Q9NYW8]3EBI-358049,EBI-1210429
RP9 [Q8TA86]3EBI-358049,EBI-630339
RUBCN [Q92622]3EBI-358049,EBI-2952709
SMN2 [Q16637]8EBI-358049,EBI-395421
SNW1 [Q13573]3EBI-358049,EBI-632715
SSX2IP [Q9Y2D8]5EBI-358049,EBI-2212028
STX11 [O75558]8EBI-358049,EBI-714135
TEKT1 [Q969V4]6EBI-358049,EBI-10180409
TFIP11 [Q9UBB9]3EBI-358049,EBI-1105213
THAP1 [Q9NVV9]8EBI-358049,EBI-741515
TLE5 [Q08117]5EBI-358049,EBI-717810
TLE5 - isoform 2 [Q08117-2]5EBI-358049,EBI-11741437
TNIP1 [Q15025]8EBI-358049,EBI-357849
TRAF2 [Q12933]3EBI-358049,EBI-355744
TRAF4 [Q9BUZ4]9EBI-358049,EBI-3650647
TRIM14 [Q14142]3EBI-358049,EBI-2820256
TRIM27 [P14373]6EBI-358049,EBI-719493
TRIM37 [O94972]9EBI-358049,EBI-741602
TRIM38 [O00635]3EBI-358049,EBI-2130415
TRIM41 [Q8WV44]5EBI-358049,EBI-725997
TRIM54 [Q9BYV2]7EBI-358049,EBI-2130429
TRIM55 - isoform 2 [Q9BYV6-2]3EBI-358049,EBI-11522718
TRIP6 [Q15654]6EBI-358049,EBI-742327
TRO [Q12816]4EBI-358049,EBI-950001
TROAP [Q12815]9EBI-358049,EBI-2349743
UBE2H [A4D1L5]3EBI-358049,EBI-10230777
USH1G [Q495M9]3EBI-358049,EBI-8601749
VIM [P08670]3EBI-358049,EBI-353844
VPS37B [Q9H9H4]8EBI-358049,EBI-4400866
VPS52 [Q8N1B4]3EBI-358049,EBI-2799833
WASF3 - isoform 2 [Q9UPY6-2]3EBI-358049,EBI-12026286
WTAP [Q15007]3EBI-358049,EBI-751647
ZBTB14 [O43829]8EBI-358049,EBI-10176632
ZBTB8A [Q96BR9]8EBI-358049,EBI-742740
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-358049,EBI-14104088
ZFP64 [Q9NTW7]5EBI-358049,EBI-711679
ZMAT5 [Q9UDW3]3EBI-358049,EBI-7850213
ZNF212 [Q9UDV6]3EBI-358049,EBI-1640204
ZNF286A [Q9HBT8]3EBI-358049,EBI-10754950
ZNF426 [Q9BUY5]3EBI-358049,EBI-743265
ZNF436 [Q9C0F3]3EBI-358049,EBI-8489702
ZNF438 [Q7Z4V0]3EBI-358049,EBI-11962468
ZNF48 [Q96MX3]3EBI-358049,EBI-12006434
ZNF581 [Q9P0T4]3EBI-358049,EBI-745520
ZNF655 [Q8N720]3EBI-358049,EBI-625509
ZNF668 - isoform 2 [Q96K58-2]3EBI-358049,EBI-12817597
ZNF71 [Q9NQZ8]3EBI-358049,EBI-7138235
ZNF774 [Q6NX45]3EBI-358049,EBI-10251462
ZNF835 [Q9Y2P0]3EBI-358049,EBI-5667516
ZRANB1 [Q9UGI0]3EBI-358049,EBI-527853
ZSCAN22 [P10073]3EBI-358049,EBI-10178224

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107167, 143 interactors

Database of interacting proteins

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DIPi
DIP-50092N

Protein interaction database and analysis system

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IntActi
Q13895, 182 interactors

Molecular INTeraction database

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MINTi
Q13895

STRING: functional protein association networks

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STRINGi
9606.ENSP00000230340

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13895 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13895

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bystin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3871 Eukaryota
ENOG410XPH5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000007241

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_029727_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13895

KEGG Orthology (KO)

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KOi
K14797

Identification of Orthologs from Complete Genome Data

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OMAi
IPHWEDI

Database of Orthologous Groups

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OrthoDBi
1193442at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13895

TreeFam database of animal gene trees

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TreeFami
TF312968

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007955 Bystin

The PANTHER Classification System

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PANTHERi
PTHR12821 PTHR12821, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05291 Bystin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q13895-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKFKAARGV GGQEKHAPLA DQILAGNAVR AGVREKRRGR GTGEAEEEYV
60 70 80 90 100
GPRLSRRILQ QARQQQEELE AEHGTGDKPA APRERTTRLG PRMPQDGSDD
110 120 130 140 150
EDEEWPTLEK AATMTAAGHH AEVVVDPEDE RAIEMFMNKN PPARRTLADI
160 170 180 190 200
IMEKLTEKQT EVETVMSEVS GFPMPQLDPR VLEVYRGVRE VLSKYRSGKL
210 220 230 240 250
PKAFKIIPAL SNWEQILYVT EPEAWTAAAM YQATRIFASN LKERMAQRFY
260 270 280 290 300
NLVLLPRVRD DVAEYKRLNF HLYMALKKAL FKPGAWFKGI LIPLCESGTC
310 320 330 340 350
TLREAIIVGS IITKCSIPVL HSSAAMLKIA EMEYSGANSI FLRLLLDKKY
360 370 380 390 400
ALPYRVLDAL VFHFLGFRTE KRELPVLWHQ CLLTLVQRYK ADLATDQKEA
410 420 430
LLELLRLQPH PQLSPEIRRE LQSAVPRDVE DVPITVE
Length:437
Mass (Da):49,601
Last modified:May 30, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A8C5E5EB108DF1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBL2F8WBL2_HUMAN
Bystin
BYSL
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BY94H7BY94_HUMAN
Bystin
BYSL
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC16603 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti214E → D in AAH07340 (PubMed:15489334).Curated1
Sequence conflicti263A → G in AAC16603 (PubMed:9560222).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033641103E → K. Corresponds to variant dbSNP:rs2296916Ensembl.1
Natural variantiVAR_048439426P → S. Corresponds to variant dbSNP:rs3828855Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC007340 mRNA Translation: AAH07340.3
BC050645 mRNA Translation: AAH50645.1
BC062627 mRNA Translation: AAH62627.2
L36720 mRNA Translation: AAC16603.2 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS34450.1

NCBI Reference Sequences

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RefSeqi
NP_004044.3, NM_004053.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000230340; ENSP00000230340; ENSG00000112578

Database of genes from NCBI RefSeq genomes

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GeneIDi
705

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:705

UCSC genome browser

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UCSCi
uc003orl.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007340 mRNA Translation: AAH07340.3
BC050645 mRNA Translation: AAH50645.1
BC062627 mRNA Translation: AAH62627.2
L36720 mRNA Translation: AAC16603.2 Different initiation.
CCDSiCCDS34450.1
RefSeqiNP_004044.3, NM_004053.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G18electron microscopy3.60w1-437[»]
6G4Selectron microscopy4.00w1-437[»]
6G4Welectron microscopy4.50w1-437[»]
SMRiQ13895
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107167, 143 interactors
DIPiDIP-50092N
IntActiQ13895, 182 interactors
MINTiQ13895
STRINGi9606.ENSP00000230340

PTM databases

iPTMnetiQ13895
MetOSiteiQ13895
PhosphoSitePlusiQ13895
SwissPalmiQ13895

Polymorphism and mutation databases

BioMutaiBYSL
DMDMi108884834

2D gel databases

SWISS-2DPAGEiQ13895

Proteomic databases

EPDiQ13895
jPOSTiQ13895
MassIVEiQ13895
MaxQBiQ13895
PaxDbiQ13895
PeptideAtlasiQ13895
PRIDEiQ13895
ProteomicsDBi59718

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30110 76 antibodies

The DNASU plasmid repository

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DNASUi
705

Genome annotation databases

EnsembliENST00000230340; ENSP00000230340; ENSG00000112578
GeneIDi705
KEGGihsa:705
UCSCiuc003orl.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
705
DisGeNETi705

GeneCards: human genes, protein and diseases

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GeneCardsi
BYSL
HGNCiHGNC:1157 BYSL
HPAiENSG00000112578 Low tissue specificity
MIMi603871 gene
neXtProtiNX_Q13895
OpenTargetsiENSG00000112578
PharmGKBiPA25472

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3871 Eukaryota
ENOG410XPH5 LUCA
GeneTreeiENSGT00390000007241
HOGENOMiCLU_029727_0_0_1
InParanoidiQ13895
KOiK14797
OMAiIPHWEDI
OrthoDBi1193442at2759
PhylomeDBiQ13895
TreeFamiTF312968

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BYSL human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
BYSL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
705
PharosiQ13895 Tbio

Protein Ontology

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PROi
PR:Q13895
RNActiQ13895 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112578 Expressed in left coronary artery and 147 other tissues
ExpressionAtlasiQ13895 baseline and differential
GenevisibleiQ13895 HS

Family and domain databases

InterProiView protein in InterPro
IPR007955 Bystin
PANTHERiPTHR12821 PTHR12821, 1 hit
PfamiView protein in Pfam
PF05291 Bystin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBYST_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13895
Secondary accession number(s): Q6P5W4, Q86W44, Q96IP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 30, 2006
Last modified: April 22, 2020
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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