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UniProtKB - Q13887 (KLF5_HUMAN)
Protein
Krueppel-like factor 5
Gene
KLF5
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 373 – 397 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 403 – 427 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 433 – 455 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- MRF binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- angiogenesis Source: Ensembl
- cell-cell signaling via exosome Source: BHF-UCL
- cellular response to leukemia inhibitory factor Source: Ensembl
- intestinal epithelial cell development Source: Ensembl
- microvillus assembly Source: Ensembl
- myotube differentiation involved in skeletal muscle regeneration Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of fat cell differentiation Source: Ensembl
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- positive regulation of transcription by transcription factor localization Source: Ensembl
- regulation of microvillus assembly Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- satellite cell activation involved in skeletal muscle regeneration Source: Ensembl
- skeletal muscle satellite cell differentiation Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q13887 |
Reactomei | R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-9616222, Transcriptional regulation of granulopoiesis |
SignaLinki | Q13887 |
SIGNORi | Q13887 |
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel-like factor 5Alternative name(s): Basic transcription element-binding protein 2 Short name: BTE-binding protein 2 Colon krueppel-like factor GC-box-binding protein 2 Intestinal-enriched krueppel-like factor Transcription factor BTEB2 |
Gene namesi | Name:KLF5 Synonyms:BTEB2, CKLF, IKLF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6349, KLF5 |
MIMi | 602903, gene |
neXtProti | NX_Q13887 |
VEuPathDBi | HostDB:ENSG00000102554 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- chromatin Source: NTNU_SB
- intracellular membrane-bounded organelle Source: HPA
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 324 – 328 | Missing : Impairs ubiquitination and degradation. 1 Publication | 5 |
Organism-specific databases
DisGeNETi | 688 |
MalaCardsi | KLF5 |
OpenTargetsi | ENSG00000102554 |
PharmGKBi | PA30139 |
Miscellaneous databases
Pharosi | Q13887, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1293249 |
Genetic variation databases
BioMutai | KLF5 |
DMDMi | 12644412 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047169 | 1 – 457 | Krueppel-like factor 5Add BLAST | 457 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 31 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 52 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 94 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 110 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.1 Publication
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q13887 |
jPOSTi | Q13887 |
MassIVEi | Q13887 |
MaxQBi | Q13887 |
PaxDbi | Q13887 |
PeptideAtlasi | Q13887 |
PRIDEi | Q13887 |
ProteomicsDBi | 527 59715 [Q13887-1] |
PTM databases
GlyGeni | Q13887, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q13887 |
PhosphoSitePlusi | Q13887 |
Expressioni
Tissue specificityi
Expressed only in testis and placenta.
Gene expression databases
Bgeei | ENSG00000102554, Expressed in palpebral conjunctiva and 224 other tissues |
ExpressionAtlasi | Q13887, baseline and differential |
Genevisiblei | Q13887, HS |
Organism-specific databases
HPAi | ENSG00000102554, Tissue enhanced (esophagus, skin) |
Interactioni
Subunit structurei
Interacts with WWP1.
Interacts with ANP32B; this interaction induces promoter region-specific histone incorporation and inhibition of histone acetylation by ANP32B.
2 PublicationsBinary interactionsi
Q13887
GO - Molecular functioni
- MRF binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107153, 62 interactors |
IntActi | Q13887, 16 interactors |
MINTi | Q13887 |
STRINGi | 9606.ENSP00000366915 |
Chemistry databases
BindingDBi | Q13887 |
Miscellaneous databases
RNActi | Q13887, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q13887 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13887 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 83 | DisorderedSequence analysisAdd BLAST | 83 | |
Regioni | 295 – 321 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 324 – 328 | Interaction with WWP11 Publication | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 118 – 126 | 9aaTAD1 Publication | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 63 – 80 | Pro residuesSequence analysisAdd BLAST | 18 |
Domaini
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 373 – 397 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 403 – 427 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 433 – 455 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156711 |
InParanoidi | Q13887 |
OMAi | FQTRCEM |
PhylomeDBi | Q13887 |
TreeFami | TF350556 |
Family and domain databases
InterProi | View protein in InterPro IPR030401, KLF5 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF82, PTHR23235:SF82, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q13887-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE
60 70 80 90 100
LKHAHHRPQA QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL
110 120 130 140 150
PPVPIIPEHK KYRRDSASVV DQFFTDTEGL PYSINMNVFL PDITHLRTGL
160 170 180 190 200
YKSQRPCVTH IKTEPVAIFS HQSETTAPPP APTQALPEFT SIFSSHQTAA
210 220 230 240 250
PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP SSTNQTAAMD
260 270 280 290 300
TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF
310 320 330 340 350
PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN
360 370 380 390 400
SQNIQPVRYN RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE
410 420 430 440 450
KPYKCTWEGC DWRFARSDEL TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL
HMKRHQN
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035555 | 301 | P → S in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057567 | 1 – 91 | Missing in isoform 4. Add BLAST | 91 | |
Alternative sequenceiVSP_047474 | 88 – 239 | Missing in isoform 2. 1 PublicationAdd BLAST | 152 | |
Alternative sequenceiVSP_047475 | 105 – 166 | IIPEH…KTEPV → MLLQLLLNWQFTIQIYPPPC QLTHKTSNLSDTIEGVTPIW RNDASTTAITLVAQKFIPSL LI in isoform 3. 1 PublicationAdd BLAST | 62 | |
Alternative sequenceiVSP_047476 | 167 – 457 | Missing in isoform 3. 1 PublicationAdd BLAST | 291 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132818 mRNA Translation: AAF18307.1 HF546203 mRNA Translation: CCO02789.1 HF546204 mRNA Translation: CCO02790.1 AB030824 mRNA Translation: BAA96461.1 AF287272 mRNA Translation: AAF88068.1 EF208215 mRNA Translation: ABM97548.1 AK302280 mRNA Translation: BAG63623.1 AL354720 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80526.1 BC007695 mRNA Translation: AAH07695.1 BC042131 mRNA Translation: AAH42131.1 D14520 mRNA Translation: BAA03393.1 |
CCDSi | CCDS66562.1 [Q13887-4] CCDS9448.1 [Q13887-1] |
PIRi | S35643 |
RefSeqi | NP_001273747.1, NM_001286818.1 [Q13887-4] NP_001721.2, NM_001730.4 [Q13887-1] |
Genome annotation databases
Ensembli | ENST00000377687; ENSP00000366915; ENSG00000102554 ENST00000539231; ENSP00000440407; ENSG00000102554 [Q13887-4] |
GeneIDi | 688 |
KEGGi | hsa:688 |
MANE-Selecti | ENST00000377687.6; ENSP00000366915.4; NM_001730.5; NP_001721.2 |
UCSCi | uc001vjd.5, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132818 mRNA Translation: AAF18307.1 HF546203 mRNA Translation: CCO02789.1 HF546204 mRNA Translation: CCO02790.1 AB030824 mRNA Translation: BAA96461.1 AF287272 mRNA Translation: AAF88068.1 EF208215 mRNA Translation: ABM97548.1 AK302280 mRNA Translation: BAG63623.1 AL354720 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80526.1 BC007695 mRNA Translation: AAH07695.1 BC042131 mRNA Translation: AAH42131.1 D14520 mRNA Translation: BAA03393.1 |
CCDSi | CCDS66562.1 [Q13887-4] CCDS9448.1 [Q13887-1] |
PIRi | S35643 |
RefSeqi | NP_001273747.1, NM_001286818.1 [Q13887-4] NP_001721.2, NM_001730.4 [Q13887-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EBT | NMR | - | A | 365-457 | [»] | |
SMRi | Q13887 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107153, 62 interactors |
IntActi | Q13887, 16 interactors |
MINTi | Q13887 |
STRINGi | 9606.ENSP00000366915 |
Chemistry databases
BindingDBi | Q13887 |
ChEMBLi | CHEMBL1293249 |
PTM databases
GlyGeni | Q13887, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q13887 |
PhosphoSitePlusi | Q13887 |
Genetic variation databases
BioMutai | KLF5 |
DMDMi | 12644412 |
Proteomic databases
EPDi | Q13887 |
jPOSTi | Q13887 |
MassIVEi | Q13887 |
MaxQBi | Q13887 |
PaxDbi | Q13887 |
PeptideAtlasi | Q13887 |
PRIDEi | Q13887 |
ProteomicsDBi | 527 59715 [Q13887-1] |
Protocols and materials databases
Antibodypediai | 24429, 360 antibodies from 35 providers |
DNASUi | 688 |
Genome annotation databases
Ensembli | ENST00000377687; ENSP00000366915; ENSG00000102554 ENST00000539231; ENSP00000440407; ENSG00000102554 [Q13887-4] |
GeneIDi | 688 |
KEGGi | hsa:688 |
MANE-Selecti | ENST00000377687.6; ENSP00000366915.4; NM_001730.5; NP_001721.2 |
UCSCi | uc001vjd.5, human |
Organism-specific databases
CTDi | 688 |
DisGeNETi | 688 |
GeneCardsi | KLF5 |
HGNCi | HGNC:6349, KLF5 |
HPAi | ENSG00000102554, Tissue enhanced (esophagus, skin) |
MalaCardsi | KLF5 |
MIMi | 602903, gene |
neXtProti | NX_Q13887 |
OpenTargetsi | ENSG00000102554 |
PharmGKBi | PA30139 |
VEuPathDBi | HostDB:ENSG00000102554 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156711 |
InParanoidi | Q13887 |
OMAi | FQTRCEM |
PhylomeDBi | Q13887 |
TreeFami | TF350556 |
Enzyme and pathway databases
PathwayCommonsi | Q13887 |
Reactomei | R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-9616222, Transcriptional regulation of granulopoiesis |
SignaLinki | Q13887 |
SIGNORi | Q13887 |
Miscellaneous databases
BioGRID-ORCSi | 688, 141 hits in 1077 CRISPR screens |
ChiTaRSi | KLF5, human |
EvolutionaryTracei | Q13887 |
GeneWikii | KLF5 |
GenomeRNAii | 688 |
Pharosi | Q13887, Tbio |
PROi | PR:Q13887 |
RNActi | Q13887, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102554, Expressed in palpebral conjunctiva and 224 other tissues |
ExpressionAtlasi | Q13887, baseline and differential |
Genevisiblei | Q13887, HS |
Family and domain databases
InterProi | View protein in InterPro IPR030401, KLF5 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF82, PTHR23235:SF82, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KLF5_HUMAN | |
Accessioni | Q13887Primary (citable) accession number: Q13887 Secondary accession number(s): A2TJX0 Q9UHP8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 196 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families