KLF5

Functionⁱ

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	373 – 397	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	403 – 427	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	433 – 455	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 16595680
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 16595680
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: Ensembl
cell-cell signaling via exosome
Source: BHF-UCL
Inferred from direct assayⁱ
- 28408180
cellular response to leukemia inhibitory factor Source: Ensembl
cellular response to organic cyclic compound Source: Ensembl
cellular response to peptide Source: Ensembl
intestinal epithelial cell development Source: Ensembl
microvillus assembly Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of fat cell differentiation Source: Ensembl
positive regulation of pri-miRNA transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 28408180
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 16595680
regulation of microvillus assembly Source: Ensembl
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
skeletal muscle cell differentiation Source: Ensembl
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 8479902

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkⁱ	Q13887
SIGNORⁱ	Q13887

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Krueppel-like factor 5 Alternative name(s): Basic transcription element-binding protein 2 Short name: BTE-binding protein 2 Colon krueppel-like factor GC-box-binding protein 2 Intestinal-enriched krueppel-like factor Transcription factor BTEB2
Gene namesⁱ	Name:KLF5 Synonyms:BTEB2, CKLF, IKLF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102554.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6349 KLF5
MIMⁱ	602903 gene
neXtProtⁱ	NX_Q13887

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	324 – 328	Missing : Impairs ubiquitination and degradation. 1 Publication		5

Organism-specific databases

DisGeNET More...DisGeNETⁱ	688
Open Targets More...OpenTargetsⁱ	ENSG00000102554
PharmGKBⁱ	PA30139

Chemistry databases

ChEMBLⁱ	CHEMBL1293249

ChEMBLⁱ

CHEMBL1293249

Polymorphism and mutation databases

DMDMⁱ	12644412

DMDMⁱ

12644412

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047169	1 – 457	Krueppel-like factor 5Add BLAST		457

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Cross-linkⁱ	31	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	52	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	94	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	110	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q13887
PaxDbⁱ	Q13887
PeptideAtlas More...PeptideAtlasⁱ	Q13887
PRIDEⁱ	Q13887
ProteomicsDBⁱ	59715

PTM databases

iPTMnetⁱ	Q13887
PhosphoSitePlusⁱ	Q13887

Expressionⁱ

Tissue specificityⁱ

Expressed only in testis and placenta.

Gene expression databases

Bgeeⁱ	ENSG00000102554 Expressed in 210 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_CKLF HS_KLF5
ExpressionAtlasⁱ	Q13887 baseline and differential
Genevisibleⁱ	Q13887 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040398

HPAⁱ

HPA040398

Interactionⁱ

Subunit structureⁱ

Interacts with WWP1.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
UBC	P0CG48	2	EBI-2696013,EBI-3390054

With

Entry

#Exp.

IntAct

Notes

UBC

P0CG48

2

EBI-2696013,EBI-3390054

GO - Molecular functionⁱ

transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107153, 51 interactors
IntActⁱ	Q13887, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q13887
STRINGⁱ	9606.ENSP00000366915

Chemistry databases

BindingDBⁱ

Q13887

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	377 – 379	Combined sources	3
Beta strandⁱ	383 – 385	Combined sources	3
Helixⁱ	387 – 397	Combined sources	11
Beta strandⁱ	407 – 409	Combined sources	3
Beta strandⁱ	413 – 416	Combined sources	4
Helixⁱ	417 – 427	Combined sources	11
Beta strandⁱ	436 – 438	Combined sources	3
Helixⁱ	445 – 455	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13887
SMRⁱ	Q13887
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13887

EvolutionaryTraceⁱ

Q13887

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	324 – 328	Interaction with WWP11 Publication		5

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	373 – 397	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	403 – 427	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	433 – 455	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118998
HOGENOMⁱ	HOG000261607
HOVERGENⁱ	HBG003474
InParanoidⁱ	Q13887
KEGG Orthology (KO) More...KOⁱ	K09206
OMAⁱ	MPNQFLQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	Q13887
TreeFamⁱ	TF350556

Family and domain databases

InterProⁱ	View protein in InterPro IPR030401 KLF5 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44295:SF4 PTHR44295:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q13887-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE 
        60         70         80         90        100
LKHAHHRPQA QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL 
       110        120        130        140        150
PPVPIIPEHK KYRRDSASVV DQFFTDTEGL PYSINMNVFL PDITHLRTGL 
       160        170        180        190        200
YKSQRPCVTH IKTEPVAIFS HQSETTAPPP APTQALPEFT SIFSSHQTAA 
       210        220        230        240        250
PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP SSTNQTAAMD 
       260        270        280        290        300
TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF 
       310        320        330        340        350
PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN 
       360        370        380        390        400
SQNIQPVRYN RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE 
       410        420        430        440        450
KPYKCTWEGC DWRFARSDEL TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL 

HMKRHQN

Length:457

Mass (Da):50,792

Last modified:December 1, 2000 - v2

Checksum:ⁱ3BF12BE272716E57

GO

Isoform 2 (identifier: Q13887-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
88-239: Missing.

« Hide

        10         20         30         40         50
MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE 
        60         70         80         90        100
LKHAHHRPQA QPAPAQAPQP AQPPATGPRL PPEDLVQPSS TNQTAAMDTL 
       110        120        130        140        150
NVSMSAAMAG LNTHTSAVPQ TAVKQFQGMP PCTYTMPSQF LPQQATYFPP 
       160        170        180        190        200
SPPSSEPGSP DRQAEMLQNL TPPPSYAATI ASKLAIHNPN LPTTLPVNSQ 
       210        220        230        240        250
NIQPVRYNRR SNPDLEKRRI HYCDYPGCTK VYTKSSHLKA HLRTHTGEKP 
       260        270        280        290        300
YKCTWEGCDW RFARSDELTR HYRKHTGAKP FQCGVCNRSF SRSDHLALHM 

KRHQN

Show »

Length:305

Mass (Da):33,618

Checksum:ⁱ0C584B65B6ED3BD1

GO

Isoform 3 (identifier: Q13887-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
105-166: IIPEHKKYRR...CVTHIKTEPV → MLLQLLLNWQ...AQKFIPSLLI
167-457: Missing.

« Hide

        10         20         30         40         50
MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE 
        60         70         80         90        100
LKHAHHRPQA QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL 
       110        120        130        140        150
PPVPMLLQLL LNWQFTIQIY PPPCQLTHKT SNLSDTIEGV TPIWRNDAST 
       160 
TAITLVAQKF IPSLLI

Show »

Length:166

Mass (Da):18,116

Checksum:ⁱ4210629ABFC9175C

GO

Isoform 4 (identifier: Q13887-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-91: Missing.

« Hide

        10         20         30         40         50
MEKYLTPQLP PVPIIPEHKK YRRDSASVVD QFFTDTEGLP YSINMNVFLP 
        60         70         80         90        100
DITHLRTGLY KSQRPCVTHI KTEPVAIFSH QSETTAPPPA PTQALPEFTS 
       110        120        130        140        150
IFSSHQTAAP EVNNIFIKQE LPTPDLHLSV PTQQGHLYQL LNTPDLDMPS 
       160        170        180        190        200
STNQTAAMDT LNVSMSAAMA GLNTHTSAVP QTAVKQFQGM PPCTYTMPSQ 
       210        220        230        240        250
FLPQQATYFP PSPPSSEPGS PDRQAEMLQN LTPPPSYAAT IASKLAIHNP 
       260        270        280        290        300
NLPTTLPVNS QNIQPVRYNR RSNPDLEKRR IHYCDYPGCT KVYTKSSHLK 
       310        320        330        340        350
AHLRTHTGEK PYKCTWEGCD WRFARSDELT RHYRKHTGAK PFQCGVCNRS 
       360 
FSRSDHLALH MKRHQN

Show »

Length:366

Mass (Da):41,180

Checksum:ⁱ81C5C45788433D2F

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035555	301	P → S in a colorectal cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_057567	1 – 91	Missing in isoform 4. Add BLAST	91
Alternative sequenceⁱVSP_047474	88 – 239	Missing in isoform 2. 1 PublicationAdd BLAST	152
Alternative sequenceⁱVSP_047475	105 – 166	IIPEH…KTEPV → MLLQLLLNWQFTIQIYPPPC QLTHKTSNLSDTIEGVTPIW RNDASTTAITLVAQKFIPSL LI in isoform 3. 1 PublicationAdd BLAST	62
Alternative sequenceⁱVSP_047476	167 – 457	Missing in isoform 3. 1 PublicationAdd BLAST	291

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF132818 mRNA Translation: AAF18307.1 HF546203 mRNA Translation: CCO02789.1 HF546204 mRNA Translation: CCO02790.1 AB030824 mRNA Translation: BAA96461.1 AF287272 mRNA Translation: AAF88068.1 EF208215 mRNA Translation: ABM97548.1 AK302280 mRNA Translation: BAG63623.1 AL354720 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80526.1 BC007695 mRNA Translation: AAH07695.1 BC042131 mRNA Translation: AAH42131.1 D14520 mRNA Translation: BAA03393.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS66562.1 [Q13887-4] CCDS9448.1 [Q13887-1]
PIRⁱ	S35643
NCBI Reference Sequences More...RefSeqⁱ	NP_001273747.1, NM_001286818.1 [Q13887-4] NP_001721.2, NM_001730.4 [Q13887-1]
UniGeneⁱ	Hs.508234

Genome annotation databases

Ensemblⁱ	ENST00000377687; ENSP00000366915; ENSG00000102554 [Q13887-1] ENST00000539231; ENSP00000440407; ENSG00000102554 [Q13887-4]
GeneIDⁱ	688
KEGGⁱ	hsa:688
UCSC genome browser More...UCSCⁱ	uc001vjd.5 human

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13887	Kruppel-like factor 5 (Intestinal)		HUMAN		457	UniRef100_Q13887
Isoform 4 of Krueppel-like factor 5		HUMAN		366

Protein	Similar proteins		Species	Score	Length	Source
Q13887	Kruppel-like factor 5 (Intestinal)		HUMAN		457	UniRef90_Q13887
Uncharacterized protein		MONDO		464
Uncharacterized protein		ICTTR		460
Krueppel-like factor 5 isoform X1		ODORO		460
Uncharacterized protein		PROCO		457
+78

Protein	Similar proteins		Species	Score	Length	Source
Q13887	Krueppel-like factor 5		MOUSE		446	UniRef50_Q13887
Kruppel-like factor 5 (Intestinal)		HUMAN		457
Uncharacterized protein		MONDO		464
Uncharacterized protein		ICTTR		460
Krueppel-like factor 5 isoform X1		ODORO		460
+171
Q13887-2	Kruppel like factor 5		TETNG		331	UniRef50_Q13887-2

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF132818 mRNA Translation: AAF18307.1 HF546203 mRNA Translation: CCO02789.1 HF546204 mRNA Translation: CCO02790.1 AB030824 mRNA Translation: BAA96461.1 AF287272 mRNA Translation: AAF88068.1 EF208215 mRNA Translation: ABM97548.1 AK302280 mRNA Translation: BAG63623.1 AL354720 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80526.1 BC007695 mRNA Translation: AAH07695.1 BC042131 mRNA Translation: AAH42131.1 D14520 mRNA Translation: BAA03393.1
CCDSⁱ	CCDS66562.1 [Q13887-4] CCDS9448.1 [Q13887-1]
PIRⁱ	S35643
RefSeqⁱ	NP_001273747.1, NM_001286818.1 [Q13887-4] NP_001721.2, NM_001730.4 [Q13887-1]
UniGeneⁱ	Hs.508234

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EBT	NMR	-	A	365-457	[»]
ProteinModelPortalⁱ	Q13887
SMRⁱ	Q13887
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107153, 51 interactors
IntActⁱ	Q13887, 5 interactors
MINTⁱ	Q13887
STRINGⁱ	9606.ENSP00000366915

Chemistry databases

BindingDBⁱ	Q13887
ChEMBLⁱ	CHEMBL1293249

PTM databases

iPTMnetⁱ	Q13887
PhosphoSitePlusⁱ	Q13887

Polymorphism and mutation databases

DMDMⁱ	12644412

DMDMⁱ

12644412

Proteomic databases

EPDⁱ	Q13887
PaxDbⁱ	Q13887
PeptideAtlasⁱ	Q13887
PRIDEⁱ	Q13887
ProteomicsDBⁱ	59715

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	688
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000377687; ENSP00000366915; ENSG00000102554 [Q13887-1] ENST00000539231; ENSP00000440407; ENSG00000102554 [Q13887-4]
GeneIDⁱ	688
KEGGⁱ	hsa:688
UCSCⁱ	uc001vjd.5 human

Organism-specific databases

CTDⁱ	688
DisGeNETⁱ	688
EuPathDBⁱ	HostDB:ENSG00000102554.13
GeneCardsⁱ	KLF5
HGNCⁱ	HGNC:6349 KLF5
HPAⁱ	HPA040398
MIMⁱ	602903 gene
neXtProtⁱ	NX_Q13887
OpenTargetsⁱ	ENSG00000102554
PharmGKBⁱ	PA30139
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118998
HOGENOMⁱ	HOG000261607
HOVERGENⁱ	HBG003474
InParanoidⁱ	Q13887
KOⁱ	K09206
OMAⁱ	MPNQFLQ
OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	Q13887
TreeFamⁱ	TF350556

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkⁱ	Q13887
SIGNORⁱ	Q13887

Miscellaneous databases

ChiTaRSⁱ	KLF5 human
EvolutionaryTraceⁱ	Q13887
GeneWikiⁱ	KLF5
GenomeRNAiⁱ	688
Protein Ontology More...PROⁱ	PR:Q13887
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102554 Expressed in 210 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_CKLF HS_KLF5
ExpressionAtlasⁱ	Q13887 baseline and differential
Genevisibleⁱ	Q13887 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR030401 KLF5 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44295:SF4 PTHR44295:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KLF5_HUMAN
Accessionⁱ	Q13887Primary (citable) accession number: Q13887 Secondary accession number(s): A2TJX0 , L0R3U5, L0R4T9, Q9UHP8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	December 1, 2000
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q13887 (KLF5_HUMAN)

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Krueppel-like factor 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Golgi apparatus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ