UniProtKB - Q13884 (SNTB1_HUMAN)
Beta-1-syntrophin
SNTB1
Functioni
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- PDZ domain binding Source: Ensembl
- structural molecule activity Source: InterPro
GO - Biological processi
- muscle contraction Source: ProtInc
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | Q13884 |
SignaLinki | Q13884 |
SIGNORi | Q13884 |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-1-syntrophinAlternative name(s): 59 kDa dystrophin-associated protein A1 basic component 1 Short name: DAPA1B BSYN2 Syntrophin-2 Tax interaction protein 43 Short name: TIP-43 |
Gene namesi | Name:SNTB1 Synonyms:SNT2B1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11168, SNTB1 |
MIMi | 600026, gene |
neXtProti | NX_Q13884 |
VEuPathDBi | HostDB:ENSG00000172164 |
Subcellular locationi
Plasma membrane
- sarcolemma By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Cytoskeleton
- cytoskeleton By similarity
Other locations
- Cell junction By similarity
Note: In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Plasma Membrane
- dystrophin-associated glycoprotein complex Source: GO_Central
- sarcolemma Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-KW
- focal adhesion Source: UniProtKB
- protein-containing complex Source: MGI
- synapse Source: GO_Central
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 6641 |
OpenTargetsi | ENSG00000172164 |
PharmGKBi | PA36008 |
Miscellaneous databases
Pharosi | Q13884, Tbio |
Genetic variation databases
BioMutai | SNTB1 |
DMDMi | 23822159 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources2 Publications | |||
ChainiPRO_0000184009 | 2 – 538 | Beta-1-syntrophinAdd BLAST | 537 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources2 Publications | 1 | |
Modified residuei | 87 | PhosphoserineCombined sources | 1 | |
Modified residuei | 126 | PhosphoserineCombined sources | 1 | |
Modified residuei | 205 | PhosphoserineBy similarity | 1 | |
Modified residuei | 214 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 219 | PhosphoserineCombined sources | 1 | |
Modified residuei | 232 | PhosphoserineCombined sources | 1 | |
Modified residuei | 236 | PhosphoserineBy similarity | 1 | |
Modified residuei | 389 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q13884 |
jPOSTi | Q13884 |
MassIVEi | Q13884 |
MaxQBi | Q13884 |
PaxDbi | Q13884 |
PeptideAtlasi | Q13884 |
PRIDEi | Q13884 |
ProteomicsDBi | 59711 [Q13884-1] 59712 [Q13884-2] |
TopDownProteomicsi | Q13884-2 [Q13884-2] |
PTM databases
GlyGeni | Q13884, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q13884 |
PhosphoSitePlusi | Q13884 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000172164, Expressed in left adrenal gland and 207 other tissues |
ExpressionAtlasi | Q13884, baseline and differential |
Genevisiblei | Q13884, HS |
Organism-specific databases
HPAi | ENSG00000172164, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Monomer and homodimer (Probable).
Interacts with the other members of the syntrophin family SNTA1 and SNTB2; with the sodium channel proteins SCN4A and SCN5A (By similarity).
Interacts with the viral HTLV-1 TAX protein and with dystrophin protein DMD and related proteins DTNA and UTRN.
Interacts with DTNB (By similarity).
By similarityCurated2 PublicationsBinary interactionsi
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- PDZ domain binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112524, 50 interactors |
DIPi | DIP-466N |
IntActi | Q13884, 28 interactors |
MINTi | Q13884 |
STRINGi | 9606.ENSP00000378965 |
Miscellaneous databases
RNActi | Q13884, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 298 | PH 1PROSITE-ProRule annotationAdd BLAST | 280 | |
Domaini | 112 – 195 | PDZPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 322 – 433 | PH 2PROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 482 – 538 | SUAdd BLAST | 57 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 205 – 237 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 518 – 538 | Calmodulin-bindingBy similarityAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 220 – 237 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3551, Eukaryota |
GeneTreei | ENSGT00950000182863 |
HOGENOMi | CLU_026406_3_1_1 |
InParanoidi | Q13884 |
OMAi | GENEKQW |
OrthoDBi | 1261897at2759 |
PhylomeDBi | Q13884 |
TreeFami | TF317932 |
Family and domain databases
CDDi | cd01258, PHsplit_syntrophin, 1 hit |
Gene3Di | 2.30.29.30, 3 hits 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR041428, PHsplit_syntrophin IPR015482, Syntrophin |
PANTHERi | PTHR10554, PTHR10554, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF00169, PH, 1 hit PF18012, PH_17, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVAAAAAAA GPAGAGGGRA QRSGLLEVLV RDRWHKVLVN LSEDALVLSS
60 70 80 90 100
EEGAAAYNGI GTATNGSFCR GAGAGHPGAG GAQPPDSPAG VRTAFTDLPE
110 120 130 140 150
QVPESISNQK RGVKVLKQEL GGLGISIKGG KENKMPILIS KIFKGLAADQ
160 170 180 190 200
TQALYVGDAI LSVNGADLRD ATHDEAVQAL KRAGKEVLLE VKYMREATPY
210 220 230 240 250
VKKGSPVSEI GWETPPPESP RLGGSTSDPP SSQSFSFHRD RKSIPLKMCY
260 270 280 290 300
VTRSMALADP ENRQLEIHSP DAKHTVILRS KDSATAQAWF SAIHSNVNDL
310 320 330 340 350
LTRVIAEVRE QLGKTGIAGS REIRHLGWLA EKVPGESKKQ WKPALVVLTE
360 370 380 390 400
KDLLIYDSMP RRKEAWFSPV HTYPLLATRL VHSGPGKGSP QAGVDLSFAT
410 420 430 440 450
RTGTRQGIET HLFRAETSRD LSHWTRSIVQ GCHNSAELIA EISTACTYKN
460 470 480 490 500
QECRLTIHYE NGFSITTEPQ EGAFPKTIIQ SPYEKLKMSS DDGIRMLYLD
510 520 530
FGGKDGEIQL DLHSCPKPIV FIIHSFLSAK ITRLGLVA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITC2 | A0A3B3ITC2_HUMAN | Beta-1-syntrophin | SNTB1 | 414 | Annotation score: | ||
E5RIX7 | E5RIX7_HUMAN | Beta-1-syntrophin | SNTB1 | 28 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006354 | 379 – 382 | RLVH → SPHP in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_006355 | 383 – 538 | Missing in isoform 2. 1 PublicationAdd BLAST | 156 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31529 Genomic DNA Translation: AAA81523.1 AK292655 mRNA Translation: BAF85344.1 BC098573 mRNA Translation: AAH98573.1 AF028828 mRNA Translation: AAB84253.1 |
CCDSi | CCDS6334.1 [Q13884-1] |
PIRi | I59291 |
RefSeqi | NP_066301.1, NM_021021.3 [Q13884-1] XP_011515541.1, XM_011517239.1 [Q13884-2] |
Genome annotation databases
Ensembli | ENST00000395601.7; ENSP00000378965.3; ENSG00000172164.15 ENST00000517992.2; ENSP00000431124.1; ENSG00000172164.15 |
GeneIDi | 6641 |
KEGGi | hsa:6641 |
MANE-Selecti | ENST00000517992.2; ENSP00000431124.1; NM_021021.4; NP_066301.1 |
UCSCi | uc010mdg.4, human [Q13884-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31529 Genomic DNA Translation: AAA81523.1 AK292655 mRNA Translation: BAF85344.1 BC098573 mRNA Translation: AAH98573.1 AF028828 mRNA Translation: AAB84253.1 |
CCDSi | CCDS6334.1 [Q13884-1] |
PIRi | I59291 |
RefSeqi | NP_066301.1, NM_021021.3 [Q13884-1] XP_011515541.1, XM_011517239.1 [Q13884-2] |
3D structure databases
AlphaFoldDBi | Q13884 |
SMRi | Q13884 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112524, 50 interactors |
DIPi | DIP-466N |
IntActi | Q13884, 28 interactors |
MINTi | Q13884 |
STRINGi | 9606.ENSP00000378965 |
PTM databases
GlyGeni | Q13884, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q13884 |
PhosphoSitePlusi | Q13884 |
Genetic variation databases
BioMutai | SNTB1 |
DMDMi | 23822159 |
Proteomic databases
EPDi | Q13884 |
jPOSTi | Q13884 |
MassIVEi | Q13884 |
MaxQBi | Q13884 |
PaxDbi | Q13884 |
PeptideAtlasi | Q13884 |
PRIDEi | Q13884 |
ProteomicsDBi | 59711 [Q13884-1] 59712 [Q13884-2] |
TopDownProteomicsi | Q13884-2 [Q13884-2] |
Protocols and materials databases
Antibodypediai | 13755, 156 antibodies from 24 providers |
DNASUi | 6641 |
Genome annotation databases
Ensembli | ENST00000395601.7; ENSP00000378965.3; ENSG00000172164.15 ENST00000517992.2; ENSP00000431124.1; ENSG00000172164.15 |
GeneIDi | 6641 |
KEGGi | hsa:6641 |
MANE-Selecti | ENST00000517992.2; ENSP00000431124.1; NM_021021.4; NP_066301.1 |
UCSCi | uc010mdg.4, human [Q13884-1] |
Organism-specific databases
CTDi | 6641 |
DisGeNETi | 6641 |
GeneCardsi | SNTB1 |
HGNCi | HGNC:11168, SNTB1 |
HPAi | ENSG00000172164, Tissue enhanced (liver) |
MIMi | 600026, gene |
neXtProti | NX_Q13884 |
OpenTargetsi | ENSG00000172164 |
PharmGKBi | PA36008 |
VEuPathDBi | HostDB:ENSG00000172164 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3551, Eukaryota |
GeneTreei | ENSGT00950000182863 |
HOGENOMi | CLU_026406_3_1_1 |
InParanoidi | Q13884 |
OMAi | GENEKQW |
OrthoDBi | 1261897at2759 |
PhylomeDBi | Q13884 |
TreeFami | TF317932 |
Enzyme and pathway databases
PathwayCommonsi | Q13884 |
SignaLinki | Q13884 |
SIGNORi | Q13884 |
Miscellaneous databases
BioGRID-ORCSi | 6641, 15 hits in 1070 CRISPR screens |
ChiTaRSi | SNTB1, human |
GeneWikii | SNTB1 |
GenomeRNAii | 6641 |
Pharosi | Q13884, Tbio |
PROi | PR:Q13884 |
RNActi | Q13884, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172164, Expressed in left adrenal gland and 207 other tissues |
ExpressionAtlasi | Q13884, baseline and differential |
Genevisiblei | Q13884, HS |
Family and domain databases
CDDi | cd01258, PHsplit_syntrophin, 1 hit |
Gene3Di | 2.30.29.30, 3 hits 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR041428, PHsplit_syntrophin IPR015482, Syntrophin |
PANTHERi | PTHR10554, PTHR10554, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF00169, PH, 1 hit PF18012, PH_17, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SNTB1_HUMAN | |
Accessioni | Q13884Primary (citable) accession number: Q13884 Secondary accession number(s): A8K9E0, O14912, Q4KMG8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 187 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families