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UniProtKB - Q13884 (SNTB1_HUMAN)

Protein

Beta-1-syntrophin

Gene

SNTB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • muscle contraction Source: ProtInc
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin-binding, Calmodulin-binding
LigandCalcium

Enzyme and pathway databases

SIGNORiQ13884

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 basic component 1
Short name:
DAPA1B
BSYN2
Syntrophin-2
Tax interaction protein 43
Short name:
TIP-43
Gene namesi
Name:SNTB1
Synonyms:SNT2B1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000172164.13
HGNCiHGNC:11168 SNTB1
MIMi600026 gene
neXtProtiNX_Q13884

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6641
OpenTargetsiENSG00000172164
PharmGKBiPA36008

Polymorphism and mutation databases

BioMutaiSNTB1
DMDMi23822159

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001840092 – 538Beta-1-syntrophinAdd BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei87PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei205PhosphoserineBy similarity1
Modified residuei214PhosphothreonineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei236PhosphoserineBy similarity1
Modified residuei389PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CaM-kinase II.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13884
MaxQBiQ13884
PaxDbiQ13884
PeptideAtlasiQ13884
PRIDEiQ13884
ProteomicsDBi59711
59712 [Q13884-2]
TopDownProteomicsiQ13884-2 [Q13884-2]

PTM databases

iPTMnetiQ13884
PhosphoSitePlusiQ13884

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000172164 Expressed in 194 organ(s), highest expression level in left adrenal gland
CleanExiHS_SNTB1
ExpressionAtlasiQ13884 baseline and differential
GenevisibleiQ13884 HS

Organism-specific databases

HPAiHPA024659

Interactioni

Subunit structurei

Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family SNTA1 and SNTB2; with the sodium channel proteins SCN4A and SCN5A (By similarity). Interacts with the viral HTLV-1 TAX protein and with dystrophin protein DMD and related proteins DTNA and UTRN.By similarityCurated2 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112524, 17 interactors
DIPiDIP-466N
IntActiQ13884, 7 interactors
STRINGi9606.ENSP00000378965

Structurei

3D structure databases

ProteinModelPortaliQ13884
SMRiQ13884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 298PH 1PROSITE-ProRule annotationAdd BLAST280
Domaini112 – 195PDZPROSITE-ProRule annotationAdd BLAST84
Domaini322 – 433PH 2PROSITE-ProRule annotationAdd BLAST112
Domaini482 – 538SUAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni518 – 538Calmodulin-bindingBy similarityAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 10Poly-Ala9

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity
The SU domain binds calmodulin in a calcium-dependent manner.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3551 Eukaryota
ENOG410XSII LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000231596
HOVERGENiHBG054204
InParanoidiQ13884
OMAiCIPLKMC
OrthoDBiEOG091G0O31
PhylomeDBiQ13884
TreeFamiTF317932

Family and domain databases

Gene3Di2.30.29.30, 3 hits
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR015482 Syntrophin
PANTHERiPTHR10554 PTHR10554, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13884-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVAAAAAAA GPAGAGGGRA QRSGLLEVLV RDRWHKVLVN LSEDALVLSS 
        60         70         80         90        100
EEGAAAYNGI GTATNGSFCR GAGAGHPGAG GAQPPDSPAG VRTAFTDLPE 
       110        120        130        140        150
QVPESISNQK RGVKVLKQEL GGLGISIKGG KENKMPILIS KIFKGLAADQ 
       160        170        180        190        200
TQALYVGDAI LSVNGADLRD ATHDEAVQAL KRAGKEVLLE VKYMREATPY 
       210        220        230        240        250
VKKGSPVSEI GWETPPPESP RLGGSTSDPP SSQSFSFHRD RKSIPLKMCY 
       260        270        280        290        300
VTRSMALADP ENRQLEIHSP DAKHTVILRS KDSATAQAWF SAIHSNVNDL 
       310        320        330        340        350
LTRVIAEVRE QLGKTGIAGS REIRHLGWLA EKVPGESKKQ WKPALVVLTE 
       360        370        380        390        400
KDLLIYDSMP RRKEAWFSPV HTYPLLATRL VHSGPGKGSP QAGVDLSFAT 
       410        420        430        440        450
RTGTRQGIET HLFRAETSRD LSHWTRSIVQ GCHNSAELIA EISTACTYKN 
       460        470        480        490        500
QECRLTIHYE NGFSITTEPQ EGAFPKTIIQ SPYEKLKMSS DDGIRMLYLD 
       510        520        530 
FGGKDGEIQL DLHSCPKPIV FIIHSFLSAK ITRLGLVA
Length:538
Mass (Da):58,061
Last modified:January 23, 2007 - v3
Checksum:iBF8E7B416D5CF289
GO
Isoform 2 (identifier: Q13884-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     379-382: RLVH → SPHP
     383-538: Missing.

Note: No experimental confirmation available.
Show »
Length:382
Mass (Da):40,805
Checksum:i5857392A7FCE200D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIX7E5RIX7_HUMAN
Beta-1-syntrophin
SNTB1
28Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006354379 – 382RLVH → SPHP in isoform 2. 1 Publication4
Alternative sequenceiVSP_006355383 – 538Missing in isoform 2. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31529 Genomic DNA Translation: AAA81523.1
AK292655 mRNA Translation: BAF85344.1
BC098573 mRNA Translation: AAH98573.1
AF028828 mRNA Translation: AAB84253.1
CCDSiCCDS6334.1 [Q13884-1]
PIRiI59291
RefSeqiNP_066301.1, NM_021021.3 [Q13884-1]
XP_011515541.1, XM_011517239.1 [Q13884-2]
UniGeneiHs.46701

Genome annotation databases

EnsembliENST00000395601; ENSP00000378965; ENSG00000172164 [Q13884-1]
ENST00000517992; ENSP00000431124; ENSG00000172164 [Q13884-1]
GeneIDi6641
KEGGihsa:6641
UCSCiuc010mdg.4 human [Q13884-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31529 Genomic DNA Translation: AAA81523.1
AK292655 mRNA Translation: BAF85344.1
BC098573 mRNA Translation: AAH98573.1
AF028828 mRNA Translation: AAB84253.1
CCDSiCCDS6334.1 [Q13884-1]
PIRiI59291
RefSeqiNP_066301.1, NM_021021.3 [Q13884-1]
XP_011515541.1, XM_011517239.1 [Q13884-2]
UniGeneiHs.46701

3D structure databases

ProteinModelPortaliQ13884
SMRiQ13884
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112524, 17 interactors
DIPiDIP-466N
IntActiQ13884, 7 interactors
STRINGi9606.ENSP00000378965

PTM databases

iPTMnetiQ13884
PhosphoSitePlusiQ13884

Polymorphism and mutation databases

BioMutaiSNTB1
DMDMi23822159

Proteomic databases

EPDiQ13884
MaxQBiQ13884
PaxDbiQ13884
PeptideAtlasiQ13884
PRIDEiQ13884
ProteomicsDBi59711
59712 [Q13884-2]
TopDownProteomicsiQ13884-2 [Q13884-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395601; ENSP00000378965; ENSG00000172164 [Q13884-1]
ENST00000517992; ENSP00000431124; ENSG00000172164 [Q13884-1]
GeneIDi6641
KEGGihsa:6641
UCSCiuc010mdg.4 human [Q13884-1]

Organism-specific databases

CTDi6641
DisGeNETi6641
EuPathDBiHostDB:ENSG00000172164.13
GeneCardsiSNTB1
H-InvDBiHIX0168940
HGNCiHGNC:11168 SNTB1
HPAiHPA024659
MIMi600026 gene
neXtProtiNX_Q13884
OpenTargetsiENSG00000172164
PharmGKBiPA36008
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3551 Eukaryota
ENOG410XSII LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000231596
HOVERGENiHBG054204
InParanoidiQ13884
OMAiCIPLKMC
OrthoDBiEOG091G0O31
PhylomeDBiQ13884
TreeFamiTF317932

Enzyme and pathway databases

SIGNORiQ13884

Miscellaneous databases

ChiTaRSiSNTB1 human
GeneWikiiSNTB1
GenomeRNAii6641
PROiPR:Q13884
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172164 Expressed in 194 organ(s), highest expression level in left adrenal gland
CleanExiHS_SNTB1
ExpressionAtlasiQ13884 baseline and differential
GenevisibleiQ13884 HS

Family and domain databases

Gene3Di2.30.29.30, 3 hits
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR015482 Syntrophin
PANTHERiPTHR10554 PTHR10554, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSNTB1_HUMAN
AccessioniPrimary (citable) accession number: Q13884
Secondary accession number(s): A8K9E0, O14912, Q4KMG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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