UniProtKB - Q13875 (MOBP_HUMAN)
Protein
Myelin-associated oligodendrocyte basic protein
Gene
MOBP
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.By similarity
GO - Molecular functioni
- actin binding Source: GO_Central
- myosin binding Source: GO_Central
- Rab GTPase binding Source: GO_Central
- structural constituent of myelin sheath Source: Ensembl
GO - Biological processi
- nervous system development Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | Q13875 |
Reactomei | R-HSA-8986944, Transcriptional Regulation by MECP2 |
Names & Taxonomyi
Protein namesi | Recommended name: Myelin-associated oligodendrocyte basic protein |
Gene namesi | Name:MOBP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168314.17 |
HGNCi | HGNC:7189, MOBP |
MIMi | 600948, gene |
neXtProti | NX_Q13875 |
Subcellular locationi
Other locations
Note: Present in the major dense line of CNS myelin.By similarity
Cytoskeleton
- cortical actin cytoskeleton Source: GO_Central
Mitochondrion
- mitochondrion Source: Ensembl
Other locations
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 4336 |
OpenTargetsi | ENSG00000168314 |
PharmGKBi | PA30899 |
Miscellaneous databases
Pharosi | Q13875, Tbio |
Polymorphism and mutation databases
BioMutai | MOBP |
DMDMi | 134034171 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000281025 | 1 – 183 | Myelin-associated oligodendrocyte basic proteinAdd BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 99 | PhosphoserineBy similarity | 1 | |
Modified residuei | 109 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q13875 |
PeptideAtlasi | Q13875 |
PRIDEi | Q13875 |
ProteomicsDBi | 33825 59706 [Q13875-1] 59707 [Q13875-2] 59708 [Q13875-3] |
PTM databases
iPTMneti | Q13875 |
PhosphoSitePlusi | Q13875 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168314, Expressed in inferior vagus X ganglion and 167 other tissues |
ExpressionAtlasi | Q13875, baseline and differential |
Genevisiblei | Q13875, HS |
Organism-specific databases
HPAi | ENSG00000168314, Tissue enriched (brain) |
Interactioni
Binary interactionsi
Hide detailsQ13875
Isoform 3 [Q13875-3]
GO - Molecular functioni
- actin binding Source: GO_Central
- myosin binding Source: GO_Central
- Rab GTPase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 110479, 21 interactors |
IntActi | Q13875, 16 interactors |
Miscellaneous databases
RNActi | Q13875, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 97 – 106 | 1 | 10 | |
Repeati | 107 – 116 | 2 | 10 | |
Repeati | 117 – 126 | 3 | 10 | |
Repeati | 127 – 136 | 4 | 10 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 97 – 136 | 4 X 10 AA tandem repeats of P-R-S-P-P-R-S-E-R-QAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 77 – 168 | Pro-richAdd BLAST | 92 |
Keywords - Domaini
RepeatPhylogenomic databases
GeneTreei | ENSGT00950000183138 |
HOGENOMi | CLU_2855470_0_0_1 |
InParanoidi | Q13875 |
OMAi | CACQRTS |
OrthoDBi | 492485at2759 |
PhylomeDBi | Q13875 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR041282, FYVE_2 IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF02318, FYVE_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q13875-1) [UniParc]FASTAAdd to basket
Also known as: OPRP2
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQKPAKEGP RLSKNQKYSE HFSIHCCPPF TFLNSKKEIV DRKYSICKSG
60 70 80 90 100
CFYQKKEEDW ICCACQKTRT SRRAKSPQRP KQQPAAPPAV VRAPAKPRSP
110 120 130 140 150
PRSERQPRSP PRSERQPRSP PRSERQPRSP PRSERQPRPR PEVRPPPAKQ
160 170 180
RPPQKSKQQP RSSPLRGPGA SRGGSPVKAS RFW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JLT8 | C9JLT8_HUMAN | Myelin-associated oligodendrocyte b... | MOBP | 62 | Annotation score: | ||
C9JAR7 | C9JAR7_HUMAN | Myelin-associated oligodendrocyte b... | MOBP | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 28 | P → R in AAH75796 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 40 | V → E in AK127034 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 76 | S → P in BAA05660 (PubMed:7989345).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055152 | 68 | T → TSSCQRRLSSRGEPWLPPPA SFGPL in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_023933 | 70 – 81 | TSRRA…PQRPK → LKRKIRPTPKKK in isoform 3. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_023934 | 82 – 183 | Missing in isoform 3. 1 PublicationAdd BLAST | 102 | |
Alternative sequenceiVSP_023935 | 183 | Missing in isoform 2 and isoform 4. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D28113 mRNA Translation: BAA05659.1 D28114 mRNA Translation: BAA05660.1 AK127034 mRNA No translation available. AK290187 mRNA Translation: BAF82876.1 AC092058 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64588.1 CH471055 Genomic DNA Translation: EAW64592.1 BC022471 mRNA Translation: AAH22471.1 BC075796 mRNA Translation: AAH75796.1 BC119694 mRNA Translation: AAI19695.1 BC119695 mRNA Translation: AAI19696.1 |
CCDSi | CCDS2687.1 [Q13875-3] CCDS2688.1 [Q13875-1] CCDS63598.1 [Q13875-4] |
PIRi | C55663 |
RefSeqi | NP_001265251.1, NM_001278322.1 [Q13875-4] NP_001265252.1, NM_001278323.1 [Q13875-1] NP_891980.1, NM_182935.3 [Q13875-3] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D28113 mRNA Translation: BAA05659.1 D28114 mRNA Translation: BAA05660.1 AK127034 mRNA No translation available. AK290187 mRNA Translation: BAF82876.1 AC092058 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64588.1 CH471055 Genomic DNA Translation: EAW64592.1 BC022471 mRNA Translation: AAH22471.1 BC075796 mRNA Translation: AAH75796.1 BC119694 mRNA Translation: AAI19695.1 BC119695 mRNA Translation: AAI19696.1 |
CCDSi | CCDS2687.1 [Q13875-3] CCDS2688.1 [Q13875-1] CCDS63598.1 [Q13875-4] |
PIRi | C55663 |
RefSeqi | NP_001265251.1, NM_001278322.1 [Q13875-4] NP_001265252.1, NM_001278323.1 [Q13875-1] NP_891980.1, NM_182935.3 [Q13875-3] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 110479, 21 interactors |
IntActi | Q13875, 16 interactors |
PTM databases
iPTMneti | Q13875 |
PhosphoSitePlusi | Q13875 |
Polymorphism and mutation databases
BioMutai | MOBP |
DMDMi | 134034171 |
Proteomic databases
MassIVEi | Q13875 |
PeptideAtlasi | Q13875 |
PRIDEi | Q13875 |
ProteomicsDBi | 33825 59706 [Q13875-1] 59707 [Q13875-2] 59708 [Q13875-3] |
Protocols and materials databases
Antibodypediai | 28962, 178 antibodies |
DNASUi | 4336 |
Genome annotation databases
Organism-specific databases
CTDi | 4336 |
DisGeNETi | 4336 |
EuPathDBi | HostDB:ENSG00000168314.17 |
GeneCardsi | MOBP |
HGNCi | HGNC:7189, MOBP |
HPAi | ENSG00000168314, Tissue enriched (brain) |
MIMi | 600948, gene |
neXtProti | NX_Q13875 |
OpenTargetsi | ENSG00000168314 |
PharmGKBi | PA30899 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183138 |
HOGENOMi | CLU_2855470_0_0_1 |
InParanoidi | Q13875 |
OMAi | CACQRTS |
OrthoDBi | 492485at2759 |
PhylomeDBi | Q13875 |
Enzyme and pathway databases
PathwayCommonsi | Q13875 |
Reactomei | R-HSA-8986944, Transcriptional Regulation by MECP2 |
Miscellaneous databases
BioGRID-ORCSi | 4336, 2 hits in 849 CRISPR screens |
ChiTaRSi | MOBP, human |
GenomeRNAii | 4336 |
Pharosi | Q13875, Tbio |
PROi | PR:Q13875 |
RNActi | Q13875, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168314, Expressed in inferior vagus X ganglion and 167 other tissues |
ExpressionAtlasi | Q13875, baseline and differential |
Genevisiblei | Q13875, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR041282, FYVE_2 IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF02318, FYVE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MOBP_HUMAN | |
Accessioni | Q13875Primary (citable) accession number: Q13875 Secondary accession number(s): A8K2C2 Q8TBJ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot