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UniProtKB - Q13873 (BMPR2_HUMAN)

Protein

Bone morphogenetic protein receptor type-2

Gene

BMPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei230ATP1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei333Proton acceptorPROSITE-ProRule annotation1
Binding sitei351ATP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi209 – 217ATP1 Publication9
Nucleotide bindingi280 – 282ATP1 Publication3
Nucleotide bindingi337 – 338ATP1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-201451 Signaling by BMP

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13873

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13873

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-2 (EC:2.7.11.30)
Short name:
BMP type-2 receptor
Short name:
BMPR-2
Alternative name(s):
Bone morphogenetic protein receptor type II
Short name:
BMP type II receptor
Short name:
BMPR-II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BMPR2
Synonyms:PPH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000204217.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:1078 BMPR2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600799 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13873

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 150ExtracellularSequence analysisAdd BLAST124
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 1038CytoplasmicSequence analysisAdd BLAST867

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pulmonary hypertension, primary, 1 (PPH1)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
See also OMIM:178600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01367060C → Y in PPH1. 1 PublicationCorresponds to variant dbSNP:rs1085307172Ensembl.1
Natural variantiVAR_07958864S → R in PPH1; unknown pathological significance; unchanged subcellular localization. 1 Publication1
Natural variantiVAR_07304167Y → C in PPH1; significant decrease in nitric oxide synthesis by endothelial cells. 1 PublicationCorresponds to variant dbSNP:rs1085307177Ensembl.1
Natural variantiVAR_07958977I → L in PPH1; unknown pathological significance; unchanged subcellular localization. 2 Publications1
Natural variantiVAR_03310982Q → H in PPH1. 1 PublicationCorresponds to variant dbSNP:rs1085307185Ensembl.1
Natural variantiVAR_07959084C → F in PPH1; alters alternative splicing of BMPR2. 2 PublicationsCorresponds to variant dbSNP:rs1085307197Ensembl.1
Natural variantiVAR_07959187H → Y in PPH1; unknown pathological significance; unchanged subcellular localization. 2 Publications1
Natural variantiVAR_07959292Q → L in PPH1; unknown pathological significance; unchanged subcellular localization. 2 Publications1
Natural variantiVAR_079593109Q → H in PPH1; unknown pathological significance; unchanged subcellular localization. 1 Publication1
Natural variantiVAR_013671117C → Y in PPH1. 1 PublicationCorresponds to variant dbSNP:rs1085307215Ensembl.1
Natural variantiVAR_013672118C → W in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852743EnsemblClinVar.1
Natural variantiVAR_013673123C → R in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852750EnsemblClinVar.1
Natural variantiVAR_013674123C → S in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852750EnsemblClinVar.1
Natural variantiVAR_079594138P → A in PPH1; unknown pathological significance; unchanged subcellular localization. 1 Publication1
Natural variantiVAR_079595162A → P in PPH1; unknown pathological significance; unchanged subcellular localization. 2 Publications1
Natural variantiVAR_033110182G → D in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852754EnsemblClinVar.1
Natural variantiVAR_079596218 – 1038Missing in PPH1; changed localization to the plasma membrane. 1 PublicationAdd BLAST821
Natural variantiVAR_079597248R → G in PPH1; unknown pathological significance; unchanged subcellular localization. 1 Publication1
Natural variantiVAR_079598264D → N in PPH1; unknown pathological significance; unchanged subcellular localization. 2 Publications1
Natural variantiVAR_079599298 – 1038Missing in PPH1; loss of localization to the plasma membrane; localized to the cytoplasm. 1 PublicationAdd BLAST741
Natural variantiVAR_079600341V → M in PPH1; unknown pathological significance; unchanged subcellular localization. 2 PublicationsCorresponds to variant dbSNP:rs767882551Ensembl.1
Natural variantiVAR_013676347C → Y in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852744EnsemblClinVar.1
Natural variantiVAR_013677420C → R in PPH1. 1 PublicationCorresponds to variant dbSNP:rs1085307324Ensembl.1
Natural variantiVAR_079601467K → R in PPH1; unknown pathological significance; unchanged subcellular localization. 1 Publication1
Natural variantiVAR_013678483C → R in PPH1; sporadic. 2 PublicationsCorresponds to variant dbSNP:rs1085307354Ensembl.1
Natural variantiVAR_013679485D → G in PPH1; complete loss of function. 2 PublicationsCorresponds to variant dbSNP:rs137852745EnsemblClinVar.1
Natural variantiVAR_013680491R → Q in PPH1; sporadic. 1 PublicationCorresponds to variant dbSNP:rs137852749EnsemblClinVar.1
Natural variantiVAR_013681491R → W in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852746EnsemblClinVar.1
Natural variantiVAR_013682512K → T in PPH1. 1 PublicationCorresponds to variant dbSNP:rs1085307364Ensembl.1
Natural variantiVAR_013683519N → K in PPH1. Corresponds to variant dbSNP:rs1085307365Ensembl.1
Natural variantiVAR_073042863S → N in PPH1; abnormal subcellular localization; significant increase in apoptosis of endothelial cells; significant decrease in proliferation of endothelial cells; significant decrease in nitric oxide synthesis by endothelial cells; significant increase in endothelin 1 synthesis by endothelial cells. 1 PublicationCorresponds to variant dbSNP:rs1006246556Ensembl.1
Natural variantiVAR_033111899R → P in PPH1; leads to constitutive activation of the MAPK14 pathway. 1 PublicationCorresponds to variant dbSNP:rs137852752EnsemblClinVar.1
Pulmonary venoocclusive disease 1, autosomal dominant (PVOD1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by widespread fibrous obstruction and intimal thickening of septal veins and preseptal venules, a low diffusing capacity for carbon monoxide, occult alveolar hemorrhage, and nodular ground-glass opacities, septal lines and lymph node enlargement showed by high-resolution computed tomography of the chest. It is frequently associated with pulmonary capillary dilatation and proliferation, and is a rare and devastating cause of pulmonary hypertension.
See also OMIM:265450

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		659

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		BMPR2

MalaCards human disease database

More...MalaCardsi		BMPR2
MIMi178600 phenotype
265450 phenotype

Open Targets

More...OpenTargetsi		ENSG00000204217

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		275786 Drug- or toxin-induced pulmonary arterial hypertension
275777 Heritable pulmonary arterial hypertension
31837 Pulmonary venoocclusive disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25388

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5467

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1794

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BMPR2

Domain mapping of disease mutations (DMDM)

More...DMDMi		12643724

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002441527 – 1038Bone morphogenetic protein receptor type-2Add BLAST1012

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 66Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi60 ↔ 84Combined sources1 Publication
Disulfide bondi94 ↔ 117Combined sources1 Publication
Disulfide bondi99 ↔ 116Combined sources1 Publication
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 123Combined sources1 Publication
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei379PhosphothreonineCombined sources1
Modified residuei586PhosphoserineCombined sources1
Modified residuei680PhosphoserineBy similarity1
Modified residuei681PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13873

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13873

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13873

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13873

PeptideAtlas

More...PeptideAtlasi		Q13873

PRoteomics IDEntifications database

More...PRIDEi		Q13873

ProteomicsDB human proteome resource

More...ProteomicsDBi		59705

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1046

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13873

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13873

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart and liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204217 Expressed in 220 organ(s), highest expression level in upper lobe of lung

CleanEx database of gene expression profiles

More...CleanExi		HS_BMPR2

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13873 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13873 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA017385
HPA049014

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GDF5.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107127, 60 interactors

Database of interacting proteins

More...DIPi		DIP-5794N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q13873

Protein interaction database and analysis system

More...IntActi		Q13873, 37 interactors

Molecular INTeraction database

More...MINTi		Q13873

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363708

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q13873

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11038
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HLQX-ray1.45A33-131[»]
3G2FX-ray2.35A/B189-517[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q13873

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13873

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13873

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini203 – 504Protein kinasePROSITE-ProRule annotationAdd BLAST302

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi547 – 550Poly-Ser4
Compositional biasi610 – 618Poly-Thr9
Compositional biasi901 – 908Poly-Asn8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3653 Eukaryota
ENOG410XS2Z LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156449

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000043088

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG096378

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13873

KEGG Orthology (KO)

More...KOi		K04671

Identification of Orthologs from Complete Genome Data

More...OMAi		ANTVAHR

Database of Orthologous Groups

More...OrthoDBi		390511at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13873

TreeFam database of animal gene trees

More...TreeFami		TF314724

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000472 Activin_recp
IPR015770 BMPR2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR000333 TGFB_receptor

The PANTHER Classification System

More...PANTHERi		PTHR23255 PTHR23255, 1 hit
PTHR23255:SF63 PTHR23255:SF63, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01064 Activin_recp, 1 hit
PF00069 Pkinase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13873-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSSLQRPWR VPWLPWTILL VSTAAASQNQ ERLCAFKDPY QQDLGIGESR 
        60         70         80         90        100
ISHENGTILC SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV 
       110        120        130        140        150
VTTTPPSIQN GTYRFCCCST DLCNVNFTEN FPPPDTTPLS PPHSFNRDET 
       160        170        180        190        200
IIIALASVSV LAVLIVALCF GYRMLTGDRK QGLHSMNMME AAASEPSLDL 
       210        220        230        240        250
DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF INEKNIYRVP 
       260        270        280        290        300
LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 
       310        320        330        340        350
SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS 
       360        370        380        390        400
DFGLSMRLTG NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA 
       410        420        430        440        450
LKQVDMYALG LIYWEIFMRC TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ 
       460        470        480        490        500
VLVSREKQRP KFPEAWKENS LAVRSLKETI EDCWDQDAEA RLTAQCAEER 
       510        520        530        540        550
MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI GPYPDYSSSS 
       560        570        580        590        600
YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS 
       610        620        630        640        650
PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETNL HTTNVAQSIG 
       660        670        680        690        700
PTPVCLQLTE EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS 
       710        720        730        740        750
STSSSLLYPL IKLAVEATGQ QDFTQTANGQ ACLIPDVLPT QIYPLPKQQN 
       760        770        780        790        800
LPKRPTSLPL NTKNSTKEPR LKFGSKHKSN LKQVETGVAK MNTINAAEPH 
       810        820        830        840        850
VVTVTMNGVA GRNHSVNSHA ATTQYANGTV LSGQTTNIVT HRAQEMLQNQ 
       860        870        880        890        900
FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT 
       910        920        930        940        950
NSNNNNSNPC SEQDVLAQGV PSTAADPGPS KPRRAQRPNS LDLSATNVLD 
       960        970        980        990       1000
GSSIQIGEST QDGKSGSGEK IKKRVKTPYS LKRWRPSTWV ISTESLDCEV 
      1010       1020       1030 
NNNGSNRAVH SKSSTAVYLA EGGTATTMVS KDIGMNCL
Length:1,038
Mass (Da):115,201
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1389923CE574B913
GO
Isoform 2 (identifier: Q13873-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     530-530: N → R
     531-1038: Missing.

Show »
Length:530
Mass (Da):59,963
Checksum:iA1F2BC5D95F42D7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PPB5A0A1W2PPB5_HUMAN
Serine/threonine-protein kinase rec...
BMPR2
505Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti828G → R in CAA88759 (PubMed:7644468).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01367060C → Y in PPH1. 1 PublicationCorresponds to variant dbSNP:rs1085307172Ensembl.1
Natural variantiVAR_07958864S → R in PPH1; unknown pathological significance; unchanged subcellular localization. 1 Publication1
Natural variantiVAR_07304167Y → C in PPH1; significant decrease in nitric oxide synthesis by endothelial cells. 1 PublicationCorresponds to variant dbSNP:rs1085307177Ensembl.1
Natural variantiVAR_07958977I → L in PPH1; unknown pathological significance; unchanged subcellular localization. 2 Publications1
Natural variantiVAR_03310982Q → H in PPH1. 1 PublicationCorresponds to variant dbSNP:rs1085307185Ensembl.1
Natural variantiVAR_07959084C → F in PPH1; alters alternative splicing of BMPR2. 2 PublicationsCorresponds to variant dbSNP:rs1085307197Ensembl.1
Natural variantiVAR_07959187H → Y in PPH1; unknown pathological significance; unchanged subcellular localization. 2 Publications1
Natural variantiVAR_07959292Q → L in PPH1; unknown pathological significance; unchanged subcellular localization. 2 Publications1
Natural variantiVAR_079593109Q → H in PPH1; unknown pathological significance; unchanged subcellular localization. 1 Publication1
Natural variantiVAR_013671117C → Y in PPH1. 1 PublicationCorresponds to variant dbSNP:rs1085307215Ensembl.1
Natural variantiVAR_013672118C → W in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852743EnsemblClinVar.1
Natural variantiVAR_013673123C → R in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852750EnsemblClinVar.1
Natural variantiVAR_013674123C → S in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852750EnsemblClinVar.1
Natural variantiVAR_079594138P → A in PPH1; unknown pathological significance; unchanged subcellular localization. 1 Publication1
Natural variantiVAR_079595162A → P in PPH1; unknown pathological significance; unchanged subcellular localization. 2 Publications1
Natural variantiVAR_033110182G → D in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852754EnsemblClinVar.1
Natural variantiVAR_079596218 – 1038Missing in PPH1; changed localization to the plasma membrane. 1 PublicationAdd BLAST821
Natural variantiVAR_013675224E → D1 PublicationCorresponds to variant dbSNP:rs754343081Ensembl.1
Natural variantiVAR_079597248R → G in PPH1; unknown pathological significance; unchanged subcellular localization. 1 Publication1
Natural variantiVAR_079598264D → N in PPH1; unknown pathological significance; unchanged subcellular localization. 2 Publications1
Natural variantiVAR_079599298 – 1038Missing in PPH1; loss of localization to the plasma membrane; localized to the cytoplasm. 1 PublicationAdd BLAST741
Natural variantiVAR_079600341V → M in PPH1; unknown pathological significance; unchanged subcellular localization. 2 PublicationsCorresponds to variant dbSNP:rs767882551Ensembl.1
Natural variantiVAR_013676347C → Y in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852744EnsemblClinVar.1
Natural variantiVAR_013677420C → R in PPH1. 1 PublicationCorresponds to variant dbSNP:rs1085307324Ensembl.1
Natural variantiVAR_079601467K → R in PPH1; unknown pathological significance; unchanged subcellular localization. 1 Publication1
Natural variantiVAR_013678483C → R in PPH1; sporadic. 2 PublicationsCorresponds to variant dbSNP:rs1085307354Ensembl.1
Natural variantiVAR_013679485D → G in PPH1; complete loss of function. 2 PublicationsCorresponds to variant dbSNP:rs137852745EnsemblClinVar.1
Natural variantiVAR_013680491R → Q in PPH1; sporadic. 1 PublicationCorresponds to variant dbSNP:rs137852749EnsemblClinVar.1
Natural variantiVAR_013681491R → W in PPH1. 1 PublicationCorresponds to variant dbSNP:rs137852746EnsemblClinVar.1
Natural variantiVAR_013682512K → T in PPH1. 1 PublicationCorresponds to variant dbSNP:rs1085307364Ensembl.1
Natural variantiVAR_013683519N → K in PPH1. Corresponds to variant dbSNP:rs1085307365Ensembl.1
Natural variantiVAR_019996775S → N Polymorphism; unchanged subcellular localization. 3 PublicationsCorresponds to variant dbSNP:rs2228545EnsemblClinVar.1
Natural variantiVAR_073042863S → N in PPH1; abnormal subcellular localization; significant increase in apoptosis of endothelial cells; significant decrease in proliferation of endothelial cells; significant decrease in nitric oxide synthesis by endothelial cells; significant increase in endothelin 1 synthesis by endothelial cells. 1 PublicationCorresponds to variant dbSNP:rs1006246556Ensembl.1
Natural variantiVAR_033111899R → P in PPH1; leads to constitutive activation of the MAPK14 pathway. 1 PublicationCorresponds to variant dbSNP:rs137852752EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054441530N → R in isoform 2. 2 Publications1
Alternative sequenceiVSP_054442531 – 1038Missing in isoform 2. 2 PublicationsAdd BLAST508

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U25110 mRNA Translation: AAA86519.1
Z48923 mRNA Translation: CAA88759.1
D50516 mRNA Translation: BAA09094.1
U20165 mRNA Translation: AAC50105.1
AC009960 Genomic DNA Translation: AAX76517.1
AC073410 Genomic DNA Translation: AAX88941.1
AC064836 Genomic DNA Translation: AAY24146.1
CH471063 Genomic DNA Translation: EAW70309.1
BC052985 mRNA Translation: AAH52985.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33361.1 [Q13873-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I38935

NCBI Reference Sequences

More...RefSeqi		NP_001195.2, NM_001204.6 [Q13873-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.471119

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374574; ENSP00000363702; ENSG00000204217 [Q13873-2]
ENST00000374580; ENSP00000363708; ENSG00000204217 [Q13873-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		659

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:659

UCSC genome browser

More...UCSCi		uc002uzf.5 human [Q13873-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25110 mRNA Translation: AAA86519.1
Z48923 mRNA Translation: CAA88759.1
D50516 mRNA Translation: BAA09094.1
U20165 mRNA Translation: AAC50105.1
AC009960 Genomic DNA Translation: AAX76517.1
AC073410 Genomic DNA Translation: AAX88941.1
AC064836 Genomic DNA Translation: AAY24146.1
CH471063 Genomic DNA Translation: EAW70309.1
BC052985 mRNA Translation: AAH52985.1
CCDSiCCDS33361.1 [Q13873-1]
PIRiI38935
RefSeqiNP_001195.2, NM_001204.6 [Q13873-1]
UniGeneiHs.471119

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HLQX-ray1.45A33-131[»]
3G2FX-ray2.35A/B189-517[»]
ProteinModelPortaliQ13873
SMRiQ13873
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107127, 60 interactors
DIPiDIP-5794N
ELMiQ13873
IntActiQ13873, 37 interactors
MINTiQ13873
STRINGi9606.ENSP00000363708

Chemistry databases

BindingDBiQ13873
ChEMBLiCHEMBL5467
GuidetoPHARMACOLOGYi1794

PTM databases

GlyConnecti1046
iPTMnetiQ13873
PhosphoSitePlusiQ13873

Polymorphism and mutation databases

BioMutaiBMPR2
DMDMi12643724

Proteomic databases

EPDiQ13873
jPOSTiQ13873
MaxQBiQ13873
PaxDbiQ13873
PeptideAtlasiQ13873
PRIDEiQ13873
ProteomicsDBi59705

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		659
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374574; ENSP00000363702; ENSG00000204217 [Q13873-2]
ENST00000374580; ENSP00000363708; ENSG00000204217 [Q13873-1]
GeneIDi659
KEGGihsa:659
UCSCiuc002uzf.5 human [Q13873-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		659
DisGeNETi659
EuPathDBiHostDB:ENSG00000204217.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		BMPR2
GeneReviewsiBMPR2
HGNCiHGNC:1078 BMPR2
HPAiHPA017385
HPA049014
MalaCardsiBMPR2
MIMi178600 phenotype
265450 phenotype
600799 gene
neXtProtiNX_Q13873
OpenTargetsiENSG00000204217
Orphaneti275786 Drug- or toxin-induced pulmonary arterial hypertension
275777 Heritable pulmonary arterial hypertension
31837 Pulmonary venoocclusive disease
PharmGKBiPA25388

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3653 Eukaryota
ENOG410XS2Z LUCA
GeneTreeiENSGT00940000156449
HOGENOMiHOG000043088
HOVERGENiHBG096378
InParanoidiQ13873
KOiK04671
OMAiANTVAHR
OrthoDBi390511at2759
PhylomeDBiQ13873
TreeFamiTF314724

Enzyme and pathway databases

ReactomeiR-HSA-201451 Signaling by BMP
SignaLinkiQ13873
SIGNORiQ13873

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BMPR2 human
EvolutionaryTraceiQ13873

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BMPR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		659

Protein Ontology

More...PROi		PR:Q13873

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204217 Expressed in 220 organ(s), highest expression level in upper lobe of lung
CleanExiHS_BMPR2
ExpressionAtlasiQ13873 baseline and differential
GenevisibleiQ13873 HS

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR015770 BMPR2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PTHR23255:SF63 PTHR23255:SF63, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBMPR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13873
Secondary accession number(s): Q13161
, Q16569, Q4ZG08, Q53SA5, Q585T8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: January 16, 2019
This is version 207 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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