DDX39B

Functionⁱ

Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.

Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect.

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.1 Publication

Kineticsⁱ

K_M=
3.3 µM for ATP
1 Publication
Manual assertion based on experiment inⁱ
- Ref.18
  "Biochemical characterization of the ATPase and helicase activity of UAP56, an essential pre-mRNA splicing and mRNA export factor."
  Shen J., Zhang L., Zhao R.
  J. Biol. Chem. 282:22544-22550(2007) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF 94-GLY--THR-96; LYS-95; GLU-197; ASP-199 AND 228-SER--THR-230.

V_max=
0.126 µM/min/mg enzyme with ATP as substrate
1 Publication
Manual assertion based on experiment inⁱ
- Ref.18
  "Biochemical characterization of the ATPase and helicase activity of UAP56, an essential pre-mRNA splicing and mRNA export factor."
  Shen J., Zhang L., Zhao R.
  J. Biol. Chem. 282:22544-22550(2007) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF 94-GLY--THR-96; LYS-95; GLU-197; ASP-199 AND 228-SER--THR-230.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	89 – 96	ATP		8

GO - Molecular functionⁱ

ATPase activity
Source: Reactome
Inferred from experimentⁱ
- 20844015
ATP binding Source: UniProtKB-KW
ATP-dependent protein binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593880
ATP-dependent RNA helicase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17562711
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 14667819
protein-containing complex binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
RNA-dependent ATPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17562711
U4 snRNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593880
U6 snRNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593880

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

liver development Source: Ensembl
mRNA 3'-end processing Source: Reactome
mRNA export from nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 17190602
mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from genetic interactionⁱ
- 15047853
negative regulation of DNA damage checkpoint
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22144908
positive regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
positive regulation of DNA biosynthetic process Source: Ensembl
positive regulation of DNA-templated transcription, elongation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22144908
positive regulation of translation Source: Ensembl
positive regulation of vascular smooth muscle cell proliferation Source: Ensembl
RNA export from nucleus Source: Reactome
RNA secondary structure unwinding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593880
RNA splicing
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593880
spliceosomal complex assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593880
viral mRNA export from host cell nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 18974867

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Helicase, Hydrolase, RNA-binding
Biological process	mRNA processing, mRNA splicing, mRNA transport, Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187 mRNA 3'-end processing

Reactomeⁱ

R-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187 mRNA 3'-end processing

Protein family/group databases

TCDBⁱ	3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

TCDBⁱ

3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Spliceosome RNA helicase DDX39B (EC:3.6.4.13) Alternative name(s): 56 kDa U2AF65-associated protein ATP-dependent RNA helicase p47 DEAD box protein UAP56 HLA-B-associated transcript 1 protein
Gene namesⁱ	Name:DDX39B Synonyms:BAT1, UAP56
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198563.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13917 DDX39B
MIMⁱ	142560 gene
neXtProtⁱ	NX_Q13838

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	94 – 96	GKT → AAA: Loss of ATPase and helicase activity. 1 Publication	3
Mutagenesisⁱ	95	K → A: Loss of ATPase and helicase activity. 2 Publications	1
Mutagenesisⁱ	197	E → A: Loss of ATPase and helicase activity. 1 Publication	1
Mutagenesisⁱ	198	C → A: No effect on ATPase activity. 1 Publication	1
Mutagenesisⁱ	199	D → A: Increased ATPase activity and loss of helicase activity. 1 Publication	1
Mutagenesisⁱ	228 – 230	SAT → AAA: Decreased ATPase activity and loss of helicase activity. 1 Publication	3

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7919
Open Targets More...OpenTargetsⁱ	ENSG00000198563
PharmGKBⁱ	PA25262

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB02325 Isopropyl Alcohol

DrugBankⁱ

DB02325 Isopropyl Alcohol

Polymorphism and mutation databases

BioMutaⁱ	DDX39B
DMDMⁱ	2500529

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000055071	2 – 428	Spliceosome RNA helicase DDX39BAdd BLAST		427

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	36	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	36	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	38	PhosphoserineCombined sources	1
Modified residueⁱ	41	PhosphoserineCombined sources	1
Modified residueⁱ	172	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q13838
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13838
PaxDbⁱ	Q13838
PeptideAtlas More...PeptideAtlasⁱ	Q13838
PRIDEⁱ	Q13838
ProteomicsDBⁱ	59701 59702 [Q13838-2]

PTM databases

iPTMnetⁱ	Q13838
PhosphoSitePlusⁱ	Q13838
SwissPalmⁱ	Q13838

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198563 Expressed in 90 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_BAT1
ExpressionAtlasⁱ	Q13838 baseline and differential
Genevisibleⁱ	Q13838 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034012 HPA055334 HPA058450

HPAⁱ

CAB034012
HPA055334
HPA058450

Interactionⁱ

Subunit structureⁱ

Homodimer, and heterodimer with DDX39A. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex bridges ALYREF/THOC4 and the THO complex, and, in a ATP-dependent manner, ALYREF/THOC4 and SARNP/CIP29. Component of the spliceosome. Interacts directly with U2AF2. Interacts with RBM8A, RNPS1 and SRRM1, FYTTD1/UIF, THOC1, MX1 and POLDIP3. Interacts with human cytomegalovirus/HHV-5 protein UL69. Interacts with LUZP4.16 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		9	EBI-348622,EBI-348622
ALYREF	Q86V81	4	EBI-348622,EBI-347640
CHTOP	Q9Y3Y2	6	EBI-348622,EBI-347794
DDX39A	O00148	9	EBI-348622,EBI-348253
RNF4	P78317	4	EBI-348622,EBI-2340927
SARNP	P82979	5	EBI-348622,EBI-347495
SDCBP	O00560	4	EBI-348622,EBI-727004
U2AF2	P26368-2	4	EBI-348622,EBI-11097439

GO - Molecular functionⁱ

ATP-dependent protein binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593880
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 14667819

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113649, 94 interactors
CORUMⁱ	Q13838
IntActⁱ	Q13838, 64 interactors
Molecular INTeraction database More...MINTⁱ	Q13838
STRINGⁱ	9606.ENSP00000379475

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	47 – 50	Combined sources	4
Helixⁱ	54 – 62	Combined sources	9
Helixⁱ	70 – 80	Combined sources	11
Beta strandⁱ	85 – 88	Combined sources	4
Helixⁱ	95 – 106	Combined sources	12
Beta strandⁱ	116 – 119	Combined sources	4
Helixⁱ	123 – 136	Combined sources	14
Turnⁱ	137 – 139	Combined sources	3
Beta strandⁱ	145 – 149	Combined sources	5
Helixⁱ	154 – 163	Combined sources	10
Beta strandⁱ	167 – 171	Combined sources	5
Helixⁱ	173 – 181	Combined sources	9
Beta strandⁱ	183 – 185	Combined sources	3
Beta strandⁱ	192 – 197	Combined sources	6
Helixⁱ	198 – 202	Combined sources	5
Helixⁱ	205 – 216	Combined sources	12
Beta strandⁱ	220 – 229	Combined sources	10
Turnⁱ	233 – 235	Combined sources	3
Helixⁱ	236 – 240	Combined sources	5
Beta strandⁱ	247 – 250	Combined sources	4
Beta strandⁱ	263 – 268	Combined sources	6
Helixⁱ	271 – 273	Combined sources	3
Helixⁱ	274 – 284	Combined sources	11
Beta strandⁱ	288 – 293	Combined sources	6
Helixⁱ	297 – 309	Combined sources	13
Beta strandⁱ	314 – 317	Combined sources	4
Beta strandⁱ	319 – 321	Combined sources	3
Helixⁱ	323 – 334	Combined sources	12
Beta strandⁱ	335 – 337	Combined sources	3
Beta strandⁱ	339 – 345	Combined sources	7
Helixⁱ	353 – 355	Combined sources	3
Beta strandⁱ	357 – 363	Combined sources	7
Helixⁱ	368 – 378	Combined sources	11
Helixⁱ	380 – 382	Combined sources	3
Beta strandⁱ	386 – 391	Combined sources	6
Helixⁱ	394 – 407	Combined sources	14
Beta strandⁱ	411 – 413	Combined sources	3
Beta strandⁱ	417 – 419	Combined sources	3
Helixⁱ	420 – 422	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13838
SMRⁱ	Q13838
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13838

EvolutionaryTraceⁱ

Q13838

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	76 – 249	Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST		174
Domainⁱ	261 – 422	Helicase C-terminalPROSITE-ProRule annotationAdd BLAST		162

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	45 – 73	Q motifAdd BLAST		29
Motifⁱ	196 – 199	DECD box		4

Domainⁱ

The helicase C-terminal domain mediates interaction with ALYREF/THOC4.1 Publication

Sequence similaritiesⁱ

Belongs to the DEAD box helicase family. DECD subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0329 Eukaryota COG0513 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00830000128348
HOVERGENⁱ	HBG107334
InParanoidⁱ	Q13838
KEGG Orthology (KO) More...KOⁱ	K12812
OMAⁱ	HGLLQYY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H5W
PhylomeDBⁱ	Q13838
TreeFamⁱ	TF300442

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR014014 RNA_helicase_DEAD_Q_motif
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 28 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q13838-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAENDVDNEL LDYEDDEVET AAGGDGAEAP AKKDVKGSYV SIHSSGFRDF 
        60         70         80         90        100
LLKPELLRAI VDCGFEHPSE VQHECIPQAI LGMDVLCQAK SGMGKTAVFV 
       110        120        130        140        150
LATLQQLEPV TGQVSVLVMC HTRELAFQIS KEYERFSKYM PNVKVAVFFG 
       160        170        180        190        200
GLSIKKDEEV LKKNCPHIVV GTPGRILALA RNKSLNLKHI KHFILDECDK 
       210        220        230        240        250
MLEQLDMRRD VQEIFRMTPH EKQVMMFSAT LSKEIRPVCR KFMQDPMEIF 
       260        270        280        290        300
VDDETKLTLH GLQQYYVKLK DNEKNRKLFD LLDVLEFNQV VIFVKSVQRC 
       310        320        330        340        350
IALAQLLVEQ NFPAIAIHRG MPQEERLSRY QQFKDFQRRI LVATNLFGRG 
       360        370        380        390        400
MDIERVNIAF NYDMPEDSDT YLHRVARAGR FGTKGLAITF VSDENDAKIL 
       410        420 
NDVQDRFEVN ISELPDEIDI SSYIEQTR

Length:428

Mass (Da):48,991

Last modified:November 1, 1996 - v1

Checksum:ⁱ7A55167BF576FB6F

GO

Isoform 2 (identifier: Q13838-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
114-114: V → VYLGRVLGRGFWLGLV

« Hide

        10         20         30         40         50
MAENDVDNEL LDYEDDEVET AAGGDGAEAP AKKDVKGSYV SIHSSGFRDF 
        60         70         80         90        100
LLKPELLRAI VDCGFEHPSE VQHECIPQAI LGMDVLCQAK SGMGKTAVFV 
       110        120        130        140        150
LATLQQLEPV TGQVYLGRVL GRGFWLGLVS VLVMCHTREL AFQISKEYER 
       160        170        180        190        200
FSKYMPNVKV AVFFGGLSIK KDEEVLKKNC PHIVVGTPGR ILALARNKSL 
       210        220        230        240        250
NLKHIKHFIL DECDKMLEQL DMRRDVQEIF RMTPHEKQVM MFSATLSKEI 
       260        270        280        290        300
RPVCRKFMQD PMEIFVDDET KLTLHGLQQY YVKLKDNEKN RKLFDLLDVL 
       310        320        330        340        350
EFNQVVIFVK SVQRCIALAQ LLVEQNFPAI AIHRGMPQEE RLSRYQQFKD 
       360        370        380        390        400
FQRRILVATN LFGRGMDIER VNIAFNYDMP EDSDTYLHRV ARAGRFGTKG 
       410        420        430        440 
LAITFVSDEN DAKILNDVQD RFEVNISELP DEIDISSYIE QTR

Note: No experimental confirmation available.

Show »

Length:443

Mass (Da):50,679

Checksum:ⁱ5B25C9C18CA433A4

GO

Computationally mapped potential isoform sequencesⁱ

There are 28 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	Q5STU3	Q5STU3_HUMAN	Spliceosome RNA helicase DDX39B Spliceosome RNA helicase DDX39B	DDX39B	425	Annotation score:
	F6QYI9	F6QYI9_HUMAN	Spliceosome RNA helicase DDX39B Spliceosome RNA helicase DDX39B	DDX39B	187	Annotation score:
	F6WLT2	F6WLT2_HUMAN	Spliceosome RNA helicase DDX39B Spliceosome RNA helicase DDX39B	DDX39B	289	Annotation score:
	F6S4E6	F6S4E6_HUMAN	Spliceosome RNA helicase DDX39B Spliceosome RNA helicase DDX39B	DDX39B	231	Annotation score:
	F6TRA5	F6TRA5_HUMAN	Spliceosome RNA helicase DDX39B Spliceosome RNA helicase DDX39B	DDX39B	238	Annotation score:
	F6S2B7	F6S2B7_HUMAN	Spliceosome RNA helicase DDX39B Spliceosome RNA helicase DDX39B	DDX39B	132	Annotation score:
	F6R6M7	F6R6M7_HUMAN	Spliceosome RNA helicase DDX39B Spliceosome RNA helicase DDX39B	DDX39B	197	Annotation score:
	F6U6E2	F6U6E2_HUMAN	Spliceosome RNA helicase DDX39B Spliceosome RNA helicase DDX39B	DDX39B	125	Annotation score:
	F6SXL5	F6SXL5_HUMAN	Spliceosome RNA helicase DDX39B Spliceosome RNA helicase DDX39B	DDX39B	136	Annotation score:
	A0A0A0MT12	A0A0A0MT12_HUMAN	Spliceosome RNA helicase DDX39B Spliceosome RNA helicase DDX39B	DDX39B	235	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	289	Q → R in BAD96632 (Ref. 3) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_026347	114	V → VYLGRVLGRGFWLGLV in isoform 2. Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z37166 mRNA Translation: CAA85523.1 BT009909 mRNA Translation: AAP88911.1 AK222912 mRNA Translation: BAD96632.1 AB088115 Genomic DNA Translation: BAC54953.1 AB103621 Genomic DNA Translation: BAF31287.1 AB202112 Genomic DNA Translation: BAE78637.1 BA000025 Genomic DNA Translation: BAB63306.1 AL662801 Genomic DNA No translation available. AL662847 Genomic DNA No translation available. BX001040 Genomic DNA No translation available. BX248516 Genomic DNA No translation available. BX927320 Genomic DNA No translation available. CR753820 Genomic DNA No translation available. CR753864 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03404.1 BC000361 mRNA Translation: AAH00361.1 BC013006 mRNA Translation: AAH13006.1 AF029061 Genomic DNA Translation: AAB94615.1 AF029062 Genomic DNA Translation: AAC63046.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4697.1 [Q13838-1]
PIRⁱ	I37201
NCBI Reference Sequences More...RefSeqⁱ	NP_004631.1, NM_004640.6 [Q13838-1] NP_542165.1, NM_080598.5 [Q13838-1]
UniGeneⁱ	Hs.254042 Hs.730849

Genome annotation databases

Ensemblⁱ	ENST00000383508; ENSP00000373000; ENSG00000215425 [Q13838-1] ENST00000396172; ENSP00000379475; ENSG00000198563 [Q13838-1] ENST00000400295; ENSP00000383151; ENSG00000215425 [Q13838-1] ENST00000400296; ENSP00000383152; ENSG00000215425 [Q13838-1] ENST00000412106; ENSP00000393712; ENSG00000225073 [Q13838-1] ENST00000412330; ENSP00000398775; ENSG00000225859 [Q13838-1] ENST00000413678; ENSP00000391463; ENSG00000229496 [Q13838-1] ENST00000414440; ENSP00000411853; ENSG00000229496 [Q13838-1] ENST00000415689; ENSP00000390999; ENSG00000225073 [Q13838-1] ENST00000416863; ENSP00000407419; ENSG00000229496 [Q13838-1] ENST00000430784; ENSP00000399030; ENSG00000235439 [Q13838-1] ENST00000431360; ENSP00000404695; ENSG00000235439 [Q13838-1] ENST00000441425; ENSP00000388880; ENSG00000230624 [Q13838-1] ENST00000445218; ENSP00000411136; ENSG00000225859 [Q13838-1] ENST00000448296; ENSP00000405560; ENSG00000225859 [Q13838-1] ENST00000453138; ENSP00000387994; ENSG00000230624 [Q13838-1] ENST00000456476; ENSP00000400326; ENSG00000225073 [Q13838-1] ENST00000456666; ENSP00000394160; ENSG00000230624 [Q13838-1] ENST00000458640; ENSP00000416269; ENSG00000198563 [Q13838-1]
GeneIDⁱ	7919
KEGGⁱ	hsa:7919
UCSC genome browser More...UCSCⁱ	uc003ntt.4 human [Q13838-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13838	Spliceosome RNA helicase DDX39B		MACMU		428	UniRef100_Q13838
Spliceosome RNA helicase DDX39B		PANTR		428
Spliceosome RNA helicase DDX39B		PIG		428
Spliceosome RNA helicase DDX39B		PONAB		428
spliceosome RNA helicase DDX39B		TARSY		552
+42

Protein	Similar proteins		Species	Score	Length	Source
Q13838	Spliceosome RNA helicase DDX39B		MACMU		428	UniRef90_Q13838
Spliceosome RNA helicase DDX39B		PANTR		428
Spliceosome RNA helicase DDX39B		PIG		428
Spliceosome RNA helicase DDX39B		PONAB		428
Spliceosome RNA helicase DDX39B		CANLF		428
+77

Protein	Similar proteins		Species	Score	Length	Source
Q13838	Spliceosome RNA helicase DDX39B		MACMU		428	UniRef50_Q13838
Spliceosome RNA helicase DDX39B		PANTR		428
Spliceosome RNA helicase DDX39B		PIG		428
Spliceosome RNA helicase DDX39B		PONAB		428
Spliceosome RNA helicase DDX39B		CANLF		428
+735

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z37166 mRNA Translation: CAA85523.1 BT009909 mRNA Translation: AAP88911.1 AK222912 mRNA Translation: BAD96632.1 AB088115 Genomic DNA Translation: BAC54953.1 AB103621 Genomic DNA Translation: BAF31287.1 AB202112 Genomic DNA Translation: BAE78637.1 BA000025 Genomic DNA Translation: BAB63306.1 AL662801 Genomic DNA No translation available. AL662847 Genomic DNA No translation available. BX001040 Genomic DNA No translation available. BX248516 Genomic DNA No translation available. BX927320 Genomic DNA No translation available. CR753820 Genomic DNA No translation available. CR753864 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03404.1 BC000361 mRNA Translation: AAH00361.1 BC013006 mRNA Translation: AAH13006.1 AF029061 Genomic DNA Translation: AAB94615.1 AF029062 Genomic DNA Translation: AAC63046.1
CCDSⁱ	CCDS4697.1 [Q13838-1]
PIRⁱ	I37201
RefSeqⁱ	NP_004631.1, NM_004640.6 [Q13838-1] NP_542165.1, NM_080598.5 [Q13838-1]
UniGeneⁱ	Hs.254042 Hs.730849

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1T5I	X-ray	1.90	A	259-428	[»]
	1T6N	X-ray	1.94	A/B	34-251	[»]
	1XTI	X-ray	1.95	A	46-428	[»]
	1XTJ	X-ray	2.70	A	44-423	[»]
	1XTK	X-ray	2.40	A	45-428	[»]
ProteinModelPortalⁱ	Q13838
SMRⁱ	Q13838
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113649, 94 interactors
CORUMⁱ	Q13838
IntActⁱ	Q13838, 64 interactors
MINTⁱ	Q13838
STRINGⁱ	9606.ENSP00000379475

Chemistry databases

DrugBankⁱ	DB02325 Isopropyl Alcohol

DrugBankⁱ

DB02325 Isopropyl Alcohol

Protein family/group databases

TCDBⁱ	3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

TCDBⁱ

3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

PTM databases

iPTMnetⁱ	Q13838
PhosphoSitePlusⁱ	Q13838
SwissPalmⁱ	Q13838

Polymorphism and mutation databases

BioMutaⁱ	DDX39B
DMDMⁱ	2500529

Proteomic databases

EPDⁱ	Q13838
MaxQBⁱ	Q13838
PaxDbⁱ	Q13838
PeptideAtlasⁱ	Q13838
PRIDEⁱ	Q13838
ProteomicsDBⁱ	59701 59702 [Q13838-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7919
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000383508; ENSP00000373000; ENSG00000215425 [Q13838-1] ENST00000396172; ENSP00000379475; ENSG00000198563 [Q13838-1] ENST00000400295; ENSP00000383151; ENSG00000215425 [Q13838-1] ENST00000400296; ENSP00000383152; ENSG00000215425 [Q13838-1] ENST00000412106; ENSP00000393712; ENSG00000225073 [Q13838-1] ENST00000412330; ENSP00000398775; ENSG00000225859 [Q13838-1] ENST00000413678; ENSP00000391463; ENSG00000229496 [Q13838-1] ENST00000414440; ENSP00000411853; ENSG00000229496 [Q13838-1] ENST00000415689; ENSP00000390999; ENSG00000225073 [Q13838-1] ENST00000416863; ENSP00000407419; ENSG00000229496 [Q13838-1] ENST00000430784; ENSP00000399030; ENSG00000235439 [Q13838-1] ENST00000431360; ENSP00000404695; ENSG00000235439 [Q13838-1] ENST00000441425; ENSP00000388880; ENSG00000230624 [Q13838-1] ENST00000445218; ENSP00000411136; ENSG00000225859 [Q13838-1] ENST00000448296; ENSP00000405560; ENSG00000225859 [Q13838-1] ENST00000453138; ENSP00000387994; ENSG00000230624 [Q13838-1] ENST00000456476; ENSP00000400326; ENSG00000225073 [Q13838-1] ENST00000456666; ENSP00000394160; ENSG00000230624 [Q13838-1] ENST00000458640; ENSP00000416269; ENSG00000198563 [Q13838-1]
GeneIDⁱ	7919
KEGGⁱ	hsa:7919
UCSCⁱ	uc003ntt.4 human [Q13838-1]

Organism-specific databases

CTDⁱ	7919
DisGeNETⁱ	7919
EuPathDBⁱ	HostDB:ENSG00000198563.13
GeneCardsⁱ	DDX39B
HGNCⁱ	HGNC:13917 DDX39B
HPAⁱ	CAB034012 HPA055334 HPA058450
MIMⁱ	142560 gene
neXtProtⁱ	NX_Q13838
OpenTargetsⁱ	ENSG00000198563
PharmGKBⁱ	PA25262
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0329 Eukaryota COG0513 LUCA
GeneTreeⁱ	ENSGT00830000128348
HOVERGENⁱ	HBG107334
InParanoidⁱ	Q13838
KOⁱ	K12812
OMAⁱ	HGLLQYY
OrthoDBⁱ	EOG091G0H5W
PhylomeDBⁱ	Q13838
TreeFamⁱ	TF300442

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187 mRNA 3'-end processing

Reactomeⁱ

R-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187 mRNA 3'-end processing

Miscellaneous databases

ChiTaRSⁱ	DDX39B human
EvolutionaryTraceⁱ	Q13838
GeneWikiⁱ	BAT1
GenomeRNAiⁱ	7919
Protein Ontology More...PROⁱ	PR:Q13838
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198563 Expressed in 90 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_BAT1
ExpressionAtlasⁱ	Q13838 baseline and differential
Genevisibleⁱ	Q13838 HS

Family and domain databases

CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR014014 RNA_helicase_DEAD_Q_motif
Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DX39B_HUMAN
Accessionⁱ	Q13838Primary (citable) accession number: Q13838 Secondary accession number(s): B0S8C0 Q71V76
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 193 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - Q13838 (DX39B_HUMAN)

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Spliceosome RNA helicase DDX39B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

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GO - Biological processi

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Experimental Info

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Protocols and materials databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ