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Entry version 188 (07 Oct 2020)
Sequence version 2 (23 Jan 2002)
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Protein

Plakophilin-1

Gene

PKP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q13835

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-351906, Apoptotic cleavage of cell adhesion proteins
R-HSA-6798695, Neutrophil degranulation
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q13835

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plakophilin-1
Alternative name(s):
Band 6 protein
Short name:
B6P
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000081277.11

Human Gene Nomenclature Database

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HGNCi
HGNC:9023, PKP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601975, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13835

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ectodermal dysplasia-skin fragility syndrome (EDSFS)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by features of both cutaneous fragility and congenital ectodermal dysplasia affecting skin, hair and nails. There is no evidence of significant abnormalities in other epithelia or tissues. Desmosomes in the skin are small and poorly formed with widening of keratinocyte intercellular spaces and perturbed desmosome/keratin intermediate filament interactions.
Related information in OMIM

Keywords - Diseasei

Ectodermal dysplasia

Organism-specific databases

DisGeNET

More...
DisGeNETi
5317

MalaCards human disease database

More...
MalaCardsi
PKP1
MIMi604536, phenotype

Open Targets

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OpenTargetsi
ENSG00000081277

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
158668, Epidermolysis bullosa simplex due to plakophilin deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33356

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q13835, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4295817

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PKP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20138951

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642841 – 747Plakophilin-1Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei121PhosphoserineBy similarity1
Modified residuei142PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13835

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13835

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13835

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13835

PeptideAtlas

More...
PeptideAtlasi
Q13835

PRoteomics IDEntifications database

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PRIDEi
Q13835

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
59699 [Q13835-1]
59700 [Q13835-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13835

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13835

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q13835

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is widely expressed. Isoform 1 is expressed in stratified squamous, complex, glandular duct and bladder epithelia.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000081277, Expressed in skin of leg and 134 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13835, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13835, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000081277, Tissue enhanced (esophagus, skin, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
111334, 60 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q13835

Protein interaction database and analysis system

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IntActi
Q13835, 35 interactors

Molecular INTeraction database

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MINTi
Q13835

STRING: functional protein association networks

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STRINGi
9606.ENSP00000263946

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q13835, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1747
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13835

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13835

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati243 – 274ARM 1Add BLAST32
Repeati275 – 316ARM 2Add BLAST42
Repeati317 – 359ARM 3Add BLAST43
Repeati360 – 415ARM 4Add BLAST56
Repeati416 – 463ARM 5Add BLAST48
Repeati525 – 556ARM 6Add BLAST32
Repeati557 – 603ARM 7Add BLAST47
Repeati604 – 649ARM 8Add BLAST46
Repeati650 – 713ARM 9Add BLAST64

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1048, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156735

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009111_3_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13835

KEGG Orthology (KO)

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KOi
K10387

Identification of Orthologs from Complete Genome Data

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OMAi
LQHTCFQ

Database of Orthologous Groups

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OrthoDBi
765704at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13835

TreeFam database of animal gene trees

More...
TreeFami
TF321877

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR028432, Plakophilin-1
IPR028435, Plakophilin/d_Catenin

The PANTHER Classification System

More...
PANTHERi
PTHR10372, PTHR10372, 1 hit
PTHR10372:SF3, PTHR10372:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00514, Arm, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00185, ARM, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176, ARM_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: Q13835-1) [UniParc]FASTAAdd to basket
Also known as: 1b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK
60 70 80 90 100
RQKSKSSQSS TLSHSNRGSM YDGLADNYNY GTTSRSSYYS KFQAGNGSWG
110 120 130 140 150
YPIYNGTLKR EPDNRRFSSY SQMENWSRHY PRGSCNTTGA GSDICFMQKI
160 170 180 190 200
KASRSEPDLY CDPRGTLRKG TLGSKGQKTT QNRYSFYSTC SGQKAIKKCP
210 220 230 240 250
VRPPSCASKQ DPVYIPPISC NKDLSFGHSR ASSKICSEDI ECSGLTIPKA
260 270 280 290 300
VQYLSSQDEK YQAIGAYYIQ HTCFQDESAK QQVYQLGGIC KLVDLLRSPN
310 320 330 340 350
QNVQQAAAGA LRNLVFRSTT NKLETRRQNG IREAVSLLRR TGNAEIQKQL
360 370 380 390 400
TGLLWNLSST DELKEELIAD ALPVLADRVI IPFSGWCDGN SNMSREVVDP
410 420 430 440 450
EVFFNATGCL RKRLGMRELL ALVPQRATSS RVNLSSADAG RQTMRNYSGL
460 470 480 490 500
IDSLMAYVQN CVAASRCDDK SVENCMCVLH NLSYRLDAEV PTRYRQLEYN
510 520 530 540 550
ARNAYTEKSS TGCFSNKSDK MMNNNYDCPL PEEETNPKGS GWLYHSDAIR
560 570 580 590 600
TYLNLMGKSK KDATLEACAG ALQNLTASKG LMSSGMSQLI GLKEKGLPQI
610 620 630 640 650
ARLLQSGNSD VVRSGASLLS NMSRHPLLHR VMGNQVFPEV TRLLTSHTGN
660 670 680 690 700
TSNSEDILSS ACYTVRNLMA SQPQLAKQYF SSSMLNNIIN LCRSSASPKA
710 720 730 740
AEAARLLLSD MWSSKELQGV LRQQGFDRNM LGTLAGANSL RNFTSRF
Length:747
Mass (Da):82,861
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60C1BCCC50AB4E6F
GO
Isoform 1 (identifier: Q13835-2) [UniParc]FASTAAdd to basket
Also known as: 1a

The sequence of this isoform differs from the canonical sequence as follows:
     412-432: Missing.

Show »
Length:726
Mass (Da):80,497
Checksum:iAE49B9396487AD31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti154R → G in CAA55881 (PubMed:7527055).Curated1
Sequence conflicti216 – 222PPISCNK → RHLLQQ in CAA55881 (PubMed:7527055).Curated7
Sequence conflicti462V → E in CAA55881 (PubMed:7527055).Curated1
Sequence conflicti496Q → K in CAA55881 (PubMed:7527055).Curated1
Sequence conflicti506T → P in CAA55881 (PubMed:7527055).Curated1
Sequence conflicti553L → S in CAA55881 (PubMed:7527055).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033526116R → H. Corresponds to variant dbSNP:rs34626929EnsemblClinVar.1
Natural variantiVAR_033527161C → Y. Corresponds to variant dbSNP:rs34704938EnsemblClinVar.1
Natural variantiVAR_033528196I → V. Corresponds to variant dbSNP:rs35507614EnsemblClinVar.1
Natural variantiVAR_053811415G → D. Corresponds to variant dbSNP:rs1626370Ensembl.1
Natural variantiVAR_062171463A → V. Corresponds to variant dbSNP:rs10920171Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006735412 – 432Missing in isoform 1. 3 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X79293 mRNA Translation: CAA55881.1
Z34974 mRNA Translation: CAA84426.1
Z73677 Genomic DNA No translation available.
Z73678 Genomic DNA Translation: CAA98022.1
CH471067 Genomic DNA Translation: EAW91350.1
BC114571 mRNA Translation: AAI14572.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30966.1 [Q13835-1]
CCDS30967.1 [Q13835-2]

Protein sequence database of the Protein Information Resource

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PIRi
S60712

NCBI Reference Sequences

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RefSeqi
NP_000290.2, NM_000299.3 [Q13835-1]
NP_001005337.1, NM_001005337.2 [Q13835-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263946; ENSP00000263946; ENSG00000081277 [Q13835-1]
ENST00000352845; ENSP00000295597; ENSG00000081277 [Q13835-1]
ENST00000367324; ENSP00000356293; ENSG00000081277 [Q13835-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5317

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5317

UCSC genome browser

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UCSCi
uc001gwd.3, human [Q13835-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79293 mRNA Translation: CAA55881.1
Z34974 mRNA Translation: CAA84426.1
Z73677 Genomic DNA No translation available.
Z73678 Genomic DNA Translation: CAA98022.1
CH471067 Genomic DNA Translation: EAW91350.1
BC114571 mRNA Translation: AAI14572.1
CCDSiCCDS30966.1 [Q13835-1]
CCDS30967.1 [Q13835-2]
PIRiS60712
RefSeqiNP_000290.2, NM_000299.3 [Q13835-1]
NP_001005337.1, NM_001005337.2 [Q13835-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XM9X-ray2.80A244-721[»]
SMRiQ13835
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111334, 60 interactors
CORUMiQ13835
IntActiQ13835, 35 interactors
MINTiQ13835
STRINGi9606.ENSP00000263946

Chemistry databases

ChEMBLiCHEMBL4295817

PTM databases

iPTMnetiQ13835
PhosphoSitePlusiQ13835
SwissPalmiQ13835

Polymorphism and mutation databases

BioMutaiPKP1
DMDMi20138951

Proteomic databases

jPOSTiQ13835
MassIVEiQ13835
MaxQBiQ13835
PaxDbiQ13835
PeptideAtlasiQ13835
PRIDEiQ13835
ProteomicsDBi59699 [Q13835-1]
59700 [Q13835-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
20641, 204 antibodies

Genome annotation databases

EnsembliENST00000263946; ENSP00000263946; ENSG00000081277 [Q13835-1]
ENST00000352845; ENSP00000295597; ENSG00000081277 [Q13835-1]
ENST00000367324; ENSP00000356293; ENSG00000081277 [Q13835-2]
GeneIDi5317
KEGGihsa:5317
UCSCiuc001gwd.3, human [Q13835-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5317
DisGeNETi5317
EuPathDBiHostDB:ENSG00000081277.11

GeneCards: human genes, protein and diseases

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GeneCardsi
PKP1
HGNCiHGNC:9023, PKP1
HPAiENSG00000081277, Tissue enhanced (esophagus, skin, tongue)
MalaCardsiPKP1
MIMi601975, gene
604536, phenotype
neXtProtiNX_Q13835
OpenTargetsiENSG00000081277
Orphaneti158668, Epidermolysis bullosa simplex due to plakophilin deficiency
PharmGKBiPA33356

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1048, Eukaryota
GeneTreeiENSGT00940000156735
HOGENOMiCLU_009111_3_1_1
InParanoidiQ13835
KOiK10387
OMAiLQHTCFQ
OrthoDBi765704at2759
PhylomeDBiQ13835
TreeFamiTF321877

Enzyme and pathway databases

PathwayCommonsiQ13835
ReactomeiR-HSA-351906, Apoptotic cleavage of cell adhesion proteins
R-HSA-6798695, Neutrophil degranulation
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope
SignaLinkiQ13835

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
5317, 3 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PKP1, human
EvolutionaryTraceiQ13835

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PKP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5317
PharosiQ13835, Tbio

Protein Ontology

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PROi
PR:Q13835
RNActiQ13835, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000081277, Expressed in skin of leg and 134 other tissues
ExpressionAtlasiQ13835, baseline and differential
GenevisibleiQ13835, HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR028432, Plakophilin-1
IPR028435, Plakophilin/d_Catenin
PANTHERiPTHR10372, PTHR10372, 1 hit
PTHR10372:SF3, PTHR10372:SF3, 1 hit
PfamiView protein in Pfam
PF00514, Arm, 1 hit
SMARTiView protein in SMART
SM00185, ARM, 6 hits
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176, ARM_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13835
Secondary accession number(s): O00645, Q14CA0, Q15152
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: October 7, 2020
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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