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Entry version 181 (16 Oct 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Nucleolar GTP-binding protein 2

Gene

GNL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi317 – 324GTPSequence analysis8
Nucleotide bindingi361 – 365GTPSequence analysis5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar GTP-binding protein 2
Alternative name(s):
Autoantigen NGP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNL2
Synonyms:NGP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29925 GNL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609365 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13823

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi33 – 35RDR → ADA: Diffused nuclear localization, loss of nucleolar localization. 1 Publication3
Mutagenesisi39 – 40RR → AA: Diffused nuclear localization, loss of nucleolar localization. 1 Publication2
Mutagenesisi39 – 40RR → AA: No effect on nucleolar localization. 1 Publication2
Mutagenesisi49 – 50RR → AA: Diffused nuclear localization, loss of nucleolar localization. 1 Publication2
Mutagenesisi227 – 229RDP → AAA: Loss of GTP-binding. Efficient localization to the nucleus, but excluded from nucleoli. 1 Publication3
Mutagenesisi258D → A: Loss of GTP-binding. Punctate pattern throughout the nucleus, including nucleoli. 1 Publication1
Mutagenesisi323K → A: No effect on GTP-binding, nor on nucleolar localization. 1 Publication1
Mutagenesisi324S → A: No effect on GTP-binding, nor on nucleolar localization. 1 Publication1
Mutagenesisi325S → A: No effect on GTP-binding, nor on nucleolar localization. 1 Publication1
Mutagenesisi343 – 345GET → AEA: No effect on GTP-binding, nor on nucleolar localization. 1 Publication3
Mutagenesisi363 – 364PG → AA: No effect on GTP-binding, nor on nucleolar localization. 1 Publication2
Mutagenesisi463P → A: No effect on nucleolar localization; when associated with A-475. 1 Publication1
Mutagenesisi475P → A: No effect on nucleolar localization; when associated with A-463. 1 Publication1
Mutagenesisi682 – 684RRR → AAA: No effect on nucleolar localization. Predominantly cytoplasmic, with some nucleolar staining; when associated with 711-AAA-713. Diffused localization to both cytoplasm and nucleus; when associated with 711-AAA-713 and 724-AAA-726. 1 Publication3
Mutagenesisi711 – 713KKK → AAA: No effect on nucleolar localization Predominantly cytoplasmic, with some nucleolar staining; when associated with 682-AAA-684. Strong nucleolar localization, with some cytoplasmic staining; when associated with 724-AAA-726. Diffused localization to both cytoplasm and nucleus; when associated with 682-AAA-684 and 724-AAA-726. 1 Publication3
Mutagenesisi724 – 726RKK → AAA: No effect on nucleolar localization. Strong nucleolar localization, with some cytoplasmic staining; when associated with 711-AAA-713. Diffused localization to both cytoplasm and nucleus; when associated with 682-AAA-684 and 711-AAA-713. 1 Publication3

Organism-specific databases

DisGeNET

More...
DisGeNETi
29889

Open Targets

More...
OpenTargetsi
ENSG00000134697

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134944852

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13823

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GNL2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002158061 – 731Nucleolar GTP-binding protein 2Add BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei504PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13823

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13823

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q13823

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13823

PeptideAtlas

More...
PeptideAtlasi
Q13823

PRoteomics IDEntifications database

More...
PRIDEi
Q13823

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59695

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q13823

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13823

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13823

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q13823

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with the highest expression level in testis.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Up-regulated in actively dividing cells, including in peripheral blood mononuclear cells stimulated with Concanavalin-A. Down-regulated in differentiating cells, including in neural precursor cells induced to differentiate into astrocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134697 Expressed in 228 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13823 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13823 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027163
HPA060026

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LYAR and RPL23A (PubMed:26203195).

Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha (PubMed:21495629).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118942, 108 interactors

Protein interaction database and analysis system

More...
IntActi
Q13823, 65 interactors

Molecular INTeraction database

More...
MINTi
Q13823

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362153

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini207 – 368CP-type GPROSITE-ProRule annotationAdd BLAST162

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi565 – 571Poly-Glu7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2423 Eukaryota
COG1161 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00810000125524

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000189714

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13823

KEGG Orthology (KO)

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KOi
K14537

Identification of Orthologs from Complete Genome Data

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OMAi
EGQKHRH

Database of Orthologous Groups

More...
OrthoDBi
1210675at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13823

TreeFam database of animal gene trees

More...
TreeFami
TF105668

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1580.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030378 G_CP_dom
IPR023179 GTP-bd_ortho_bundle_sf
IPR006073 GTP_binding_domain
IPR024929 NOG2
IPR012971 NOG2_N_dom
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR11089:SF9 PTHR11089:SF9, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF08153 NGP1NT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00326 GTP1OBG

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51721 G_CP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q13823-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKPKYKGRS TINPSKASTN PDRVQGAGGQ NMRDRATIRR LNMYRQKERR
60 70 80 90 100
NSRGKIIKPL QYQSTVASGT VARVEPNIKW FGNTRVIKQS SLQKFQEEMD
110 120 130 140 150
TVMKDPYKVV MKQSKLPMSL LHDRIRPHNL KVHILDTESF ETTFGPKSQR
160 170 180 190 200
KRPNLFASDM QSLIENAEMS TESYDQGKDR DLVTEDTGVR NEAQEEIYKK
210 220 230 240 250
GQSKRIWGEL YKVIDSSDVV VQVLDARDPM GTRSPHIETY LKKEKPWKHL
260 270 280 290 300
IFVLNKCDLV PTWATKRWVA VLSQDYPTLA FHASLTNPFG KGAFIQLLRQ
310 320 330 340 350
FGKLHTDKKQ ISVGFIGYPN VGKSSVINTL RSKKVCNVAP IAGETKVWQY
360 370 380 390 400
ITLMRRIFLI DCPGVVYPSE DSETDIVLKG VVQVEKIKSP EDHIGAVLER
410 420 430 440 450
AKPEYISKTY KIDSWENAED FLEKLAFRTG KLLKGGEPDL QTVGKMVLND
460 470 480 490 500
WQRGRIPFFV KPPNAEPLVA PQLLPSSSLE VVPEAAQNNP GEEVTETAGE
510 520 530 540 550
GSESIIKEET EENSHCDANT EMQQILTRVR QNFGKINVVP QFSGDDLVPV
560 570 580 590 600
EVSDLEEELE SFSDEEEEEQ EQQRDDAEES SSEPEEENVG NDTKAVIKAL
610 620 630 640 650
DEKIAKYQKF LDKAKAKKFS AVRISKGLSE KIFAKPEEQR KTLEEDVDDR
660 670 680 690 700
APSKKGKKRK AQREEEQEHS NKAPRALTSK ERRRAVRQQR PKKVGVRYYE
710 720 730
THNVKNRNRN KKKTNDSEGQ KHKRKKFRQK Q
Length:731
Mass (Da):83,655
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE90C638B58C0886E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YG10H0YG10_HUMAN
Nucleolar GTP-binding protein 2
GNL2
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti284S → I in AAH00107 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050291452Q → H. Corresponds to variant dbSNP:rs12025870Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L05425 mRNA Translation: AAC37588.1
BC000107 mRNA Translation: AAH00107.1
BC009250 mRNA Translation: AAH09250.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS421.1

NCBI Reference Sequences

More...
RefSeqi
NP_037417.1, NM_013285.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373062; ENSP00000362153; ENSG00000134697

Database of genes from NCBI RefSeq genomes

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GeneIDi
29889

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29889

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05425 mRNA Translation: AAC37588.1
BC000107 mRNA Translation: AAH00107.1
BC009250 mRNA Translation: AAH09250.1
CCDSiCCDS421.1
RefSeqiNP_037417.1, NM_013285.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi118942, 108 interactors
IntActiQ13823, 65 interactors
MINTiQ13823
STRINGi9606.ENSP00000362153

PTM databases

iPTMnetiQ13823
PhosphoSitePlusiQ13823
SwissPalmiQ13823

Polymorphism and mutation databases

BioMutaiGNL2

2D gel databases

SWISS-2DPAGEiQ13823

Proteomic databases

EPDiQ13823
jPOSTiQ13823
MassIVEiQ13823
PaxDbiQ13823
PeptideAtlasiQ13823
PRIDEiQ13823
ProteomicsDBi59695

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
29889

Genome annotation databases

EnsembliENST00000373062; ENSP00000362153; ENSG00000134697
GeneIDi29889
KEGGihsa:29889

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29889
DisGeNETi29889

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GNL2
HGNCiHGNC:29925 GNL2
HPAiHPA027163
HPA060026
MIMi609365 gene
neXtProtiNX_Q13823
OpenTargetsiENSG00000134697
PharmGKBiPA134944852

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2423 Eukaryota
COG1161 LUCA
GeneTreeiENSGT00810000125524
HOGENOMiHOG000189714
InParanoidiQ13823
KOiK14537
OMAiEGQKHRH
OrthoDBi1210675at2759
PhylomeDBiQ13823
TreeFamiTF105668

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GNL2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GNL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29889
PharosiQ13823

Protein Ontology

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PROi
PR:Q13823

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000134697 Expressed in 228 organ(s), highest expression level in testis
ExpressionAtlasiQ13823 baseline and differential
GenevisibleiQ13823 HS

Family and domain databases

Gene3Di1.10.1580.10, 1 hit
InterProiView protein in InterPro
IPR030378 G_CP_dom
IPR023179 GTP-bd_ortho_bundle_sf
IPR006073 GTP_binding_domain
IPR024929 NOG2
IPR012971 NOG2_N_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11089:SF9 PTHR11089:SF9, 1 hit
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF08153 NGP1NT, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51721 G_CP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOG2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13823
Secondary accession number(s): Q9BWN7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 16, 2019
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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