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UniProtKB - Q13813 (SPTN1_HUMAN)

Entry version 222 (02 Dec 2020)
Sequence version 3 (02 May 2006)
Previous versions | rss
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Protein

Spectrin alpha chain, non-erythrocytic 1

Gene

SPTAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi2336 – 23471PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi2379 – 23902PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: ProtInc
  • cadherin binding Source: BHF-UCL
  • calcium ion binding Source: InterPro
  • calmodulin binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: ProtInc
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding, Calmodulin-binding
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13813

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-373753, Nephrin family interactions
R-HSA-375165, NCAM signaling for neurite out-growth
R-HSA-445095, Interaction between L1 and Ankyrins
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6798695, Neutrophil degranulation
R-HSA-6807878, COPI-mediated anterograde transport

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13813

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin alpha chain, non-erythrocytic 1
Alternative name(s):
Alpha-II spectrin
Fodrin alpha chain
Spectrin, non-erythroid alpha subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPTAN1
Synonyms:NEAS, SPTA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000197694.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:11273, SPTAN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182810, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13813

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epileptic encephalopathy, early infantile, 5 (EIEE5)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by seizures associated with hypsarrhythmia, profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0638862202Missing in EIEE5; could form a heterodimer with SPTBN1 but the heterodimer is thermally unstable; suggests a dominant negative effect. 2 Publications1
Natural variantiVAR_0638872304M → MRM in EIEE5; could form a heterodimer with SPTBN1 but the heterodimer is thermally unstable; suggests a dominant negative effect. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		6709

MalaCards human disease database

More...MalaCardsi		SPTAN1
MIMi613477, phenotype

Open Targets

More...OpenTargetsi		ENSG00000197694

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		3451, West syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36102

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13813, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPTAN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		94730425

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734551 – 2472Spectrin alpha chain, non-erythrocytic 1Add BLAST2472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei587PhosphoserineBy similarity1
Modified residuei637N6-acetyllysineCombined sources1
Modified residuei803N6-acetyllysineBy similarity1
Modified residuei924PhosphoserineBy similarity1
Modified residuei982PhosphoserineCombined sources1
Modified residuei999PhosphoserineCombined sources1
Modified residuei1029PhosphoserineBy similarity1
Modified residuei1031PhosphoserineCombined sources1
Modified residuei1041PhosphoserineCombined sources1
Modified residuei1176PhosphotyrosineCombined sources1
Modified residuei1190PhosphoserineBy similarity1
Modified residuei1207PhosphoserineCombined sources1
Modified residuei1217PhosphoserineCombined sources1
Modified residuei1291PhosphoserineBy similarity1
Modified residuei1306PhosphoserineCombined sources1
Modified residuei1323PhosphoserineCombined sources1
Modified residuei1338PhosphoserineCombined sources1
Modified residuei1519N6-acetyllysineCombined sources1
Modified residuei1550PhosphoserineCombined sources1
Modified residuei1557PhosphoserineCombined sources1
Modified residuei1578PhosphoserineCombined sources1
Modified residuei1615PhosphoserineCombined sources1
Modified residuei1647PhosphoserineCombined sources1
Modified residuei2020PhosphothreonineCombined sources1
Modified residuei2052N6-acetyllysineCombined sources1
Modified residuei2421N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1176 – 1177Cleavage; by mu-calpain2

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13813

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13813

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13813

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13813

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13813

PeptideAtlas

More...PeptideAtlasi		Q13813

PRoteomics IDEntifications database

More...PRIDEi		Q13813

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59689 [Q13813-1]
59690 [Q13813-2]
59691 [Q13813-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q13813

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13813

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q13813

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13813

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q13813

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197694, Expressed in frontal cortex and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13813, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13813, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197694, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers.

Interacts (via C-terminal spectrin repeats) with TRPC4.

Interacts with CALM and EMD.

Interacts with isoform 1 of ACP1.

Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1.

Interacts with SHANK3 (via ANK repeats).

Interacts with CLN3; this interaction regulates the fodrin localization at the plasma membrane (Probable).

1 Publication4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112587, 234 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q13813

Database of interacting proteins

More...DIPi		DIP-33141N

Protein interaction database and analysis system

More...IntActi		Q13813, 156 interactors

Molecular INTeraction database

More...MINTi		Q13813

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361824

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13813, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q13813

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13813

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13813

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati45 – 146Spectrin 1Sequence analysisAdd BLAST102
Repeati150 – 251Spectrin 2Sequence analysisAdd BLAST102
Repeati256 – 358Spectrin 3Sequence analysisAdd BLAST103
Repeati361 – 465Spectrin 4Sequence analysisAdd BLAST105
Repeati468 – 570Spectrin 5Sequence analysisAdd BLAST103
Repeati574 – 676Spectrin 6Sequence analysisAdd BLAST103
Repeati679 – 781Spectrin 7Sequence analysisAdd BLAST103
Repeati785 – 888Spectrin 8Sequence analysisAdd BLAST104
Repeati891 – 969Spectrin 9Sequence analysisAdd BLAST79
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini967 – 1026SH3PROSITE-ProRule annotationAdd BLAST60
Repeati1096 – 1166Spectrin 10Sequence analysisAdd BLAST71
Repeati1233 – 1336Spectrin 11Sequence analysisAdd BLAST104
Repeati1339 – 1442Spectrin 12Sequence analysis1 PublicationAdd BLAST104
Repeati1446 – 1549Spectrin 13Sequence analysis1 PublicationAdd BLAST104
Repeati1552 – 1656Spectrin 14Sequence analysisAdd BLAST105
Repeati1659 – 1762Spectrin 15Sequence analysisAdd BLAST104
Repeati1764 – 1868Spectrin 16Sequence analysisAdd BLAST105
Repeati1871 – 1974Spectrin 17Sequence analysisAdd BLAST104
Repeati1978 – 2081Spectrin 18Sequence analysisAdd BLAST104
Repeati2092 – 2194Spectrin 19Sequence analysisAdd BLAST103
Repeati2206 – 2310Spectrin 20Sequence analysisAdd BLAST105
Domaini2323 – 2358EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini2366 – 2401EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini2404 – 2439EF-hand 3PROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0040, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156662

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000847_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13813

Database of Orthologous Groups

More...OrthoDBi		543832at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13813

TreeFam database of animal gene trees

More...TreeFami		TF343803

Family and domain databases

Conserved Domains Database

More...CDDi		cd00051, EFh, 1 hit
cd11808, SH3_Alpha_Spectrin, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035825, Alpha_Spectrin_SH3
IPR011992, EF-hand-dom_pair
IPR014837, EF-hand_Ca_insen
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13499, EF-hand_7, 1 hit
PF08726, EFhand_Ca_insen, 1 hit
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 20 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 2 hits
SM00326, SH3, 1 hit
SM00150, SPEC, 20 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13813-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPSGVKVLE TAEDIQERRQ QVLDRYHRFK ELSTLRRQKL EDSYRFQFFQ 
        60         70         80         90        100
RDAEELEKWI QEKLQIASDE NYKDPTNLQG KLQKHQAFEA EVQANSGAIV 
       110        120        130        140        150
KLDETGNLMI SEGHFASETI RTRLMELHRQ WELLLEKMRE KGIKLLQAQK 
       160        170        180        190        200
LVQYLRECED VMDWINDKEA IVTSEELGQD LEHVEVLQKK FEEFQTDMAA 
       210        220        230        240        250
HEERVNEVNQ FAAKLIQEQH PEEELIKTKQ DEVNAAWQRL KGLALQRQGK 
       260        270        280        290        300
LFGAAEVQRF NRDVDETISW IKEKEQLMAS DDFGRDLASV QALLRKHEGL 
       310        320        330        340        350
ERDLAALEDK VKALCAEADR LQQSHPLSAT QIQVKREELI TNWEQIRTLA 
       360        370        380        390        400
AERHARLNDS YRLQRFLADF RDLTSWVTEM KALINADELA SDVAGAEALL 
       410        420        430        440        450
DRHQEHKGEI DAHEDSFKSA DESGQALLAA GHYASDEVRE KLTVLSEERA 
       460        470        480        490        500
ALLELWELRR QQYEQCMDLQ LFYRDTEQVD NWMSKQEAFL LNEDLGDSLD 
       510        520        530        540        550
SVEALLKKHE DFEKSLSAQE EKITALDEFA TKLIQNNHYA MEDVATRRDA 
       560        570        580        590        600
LLSRRNALHE RAMRRRAQLA DSFHLQQFFR DSDELKSWVN EKMKTATDEA 
       610        620        630        640        650
YKDPSNLQGK VQKHQAFEAE LSANQSRIDA LEKAGQKLID VNHYAKDEVA 
       660        670        680        690        700
ARMNEVISLW KKLLEATELK GIKLREANQQ QQFNRNVEDI ELWLYEVEGH 
       710        720        730        740        750
LASDDYGKDL TNVQNLQKKH ALLEADVAAH QDRIDGITIQ ARQFQDAGHF 
       760        770        780        790        800
DAENIKKKQE ALVARYEALK EPMVARKQKL ADSLRLQQLF RDVEDEETWI 
       810        820        830        840        850
REKEPIAAST NRGKDLIGVQ NLLKKHQALQ AEIAGHEPRI KAVTQKGNAM 
       860        870        880        890        900
VEEGHFAAED VKAKLHELNQ KWEALKAKAS QRRQDLEDSL QAQQYFADAN 
       910        920        930        940        950
EAESWMREKE PIVGSTDYGK DEDSAEALLK KHEALMSDLS AYGSSIQALR 
       960        970        980        990       1000
EQAQSCRQQV APTDDETGKE LVLALYDYQE KSPREVTMKK GDILTLLNST 
      1010       1020       1030       1040       1050
NKDWWKVEVN DRQGFVPAAY VKKLDPAQSA SRENLLEEQG SIALRQEQID 
      1060       1070       1080       1090       1100
NQTRITKEAG SVSLRMKQVE ELYHSLLELG EKRKGMLEKS CKKFMLFREA 
      1110       1120       1130       1140       1150
NELQQWINEK EAALTSEEVG ADLEQVEVLQ KKFDDFQKDL KANESRLKDI 
      1160       1170       1180       1190       1200
NKVAEDLESE GLMAEEVQAV QQQEVYGMMP RDETDSKTAS PWKSARLMVH 
      1210       1220       1230       1240       1250
TVATFNSIKE LNERWRSLQQ LAEERSQLLG SAHEVQRFHR DADETKEWIE 
      1260       1270       1280       1290       1300
EKNQALNTDN YGHDLASVQA LQRKHEGFER DLAALGDKVN SLGETAERLI 
      1310       1320       1330       1340       1350
QSHPESAEDL QEKCTELNQA WSSLGKRADQ RKAKLGDSHD LQRFLSDFRD 
      1360       1370       1380       1390       1400
LMSWINGIRG LVSSDELAKD VTGAEALLER HQEHRTEIDA RAGTFQAFEQ 
      1410       1420       1430       1440       1450
FGQQLLAHGH YASPEIKQKL DILDQERADL EKAWVQRRMM LDQCLELQLF 
      1460       1470       1480       1490       1500
HRDCEQAENW MAAREAFLNT EDKGDSLDSV EALIKKHEDF DKAINVQEEK 
      1510       1520       1530       1540       1550
IAALQAFADQ LIAAGHYAKG DISSRRNEVL DRWRRLKAQM IEKRSKLGES 
      1560       1570       1580       1590       1600
QTLQQFSRDV DEIEAWISEK LQTASDESYK DPTNIQSKHQ KHQAFEAELH 
      1610       1620       1630       1640       1650
ANADRIRGVI DMGNSLIERG ACAGSEDAVK ARLAALADQW QFLVQKSAEK 
      1660       1670       1680       1690       1700
SQKLKEANKQ QNFNTGIKDF DFWLSEVEAL LASEDYGKDL ASVNNLLKKH 
      1710       1720       1730       1740       1750
QLLEADISAH EDRLKDLNSQ ADSLMTSSAF DTSQVKDKRD TINGRFQKIK 
      1760       1770       1780       1790       1800
SMAASRRAKL NESHRLHQFF RDMDDEESWI KEKKLLVGSE DYGRDLTGVQ 
      1810       1820       1830       1840       1850
NLRKKHKRLE AELAAHEPAI QGVLDTGKKL SDDNTIGKEE IQQRLAQFVE 
      1860       1870       1880       1890       1900
HWKELKQLAA ARGQRLEESL EYQQFVANVE EEEAWINEKM TLVASEDYGD 
      1910       1920       1930       1940       1950
TLAAIQGLLK KHEAFETDFT VHKDRVNDVC TNGQDLIKKN NHHEENISSK 
      1960       1970       1980       1990       2000
MKGLNGKVSD LEKAAAQRKA KLDENSAFLQ FNWKADVVES WIGEKENSLK 
      2010       2020       2030       2040       2050
TDDYGRDLSS VQTLLTKQET FDAGLQAFQQ EGIANITALK DQLLAAKHVQ 
      2060       2070       2080       2090       2100
SKAIEARHAS LMKRWSQLLA NSAARKKKLL EAQSHFRKVE DLFLTFAKKA 
      2110       2120       2130       2140       2150
SAFNSWFENA EEDLTDPVRC NSLEEIKALR EAHDAFRSSL SSAQADFNQL 
      2160       2170       2180       2190       2200
AELDRQIKSF RVASNPYTWF TMEALEETWR NLQKIIKERE LELQKEQRRQ 
      2210       2220       2230       2240       2250
EENDKLRQEF AQHANAFHQW IQETRTYLLD GSCMVEESGT LESQLEATKR 
      2260       2270       2280       2290       2300
KHQEIRAMRS QLKKIEDLGA AMEEALILDN KYTEHSTVGL AQQWDQLDQL 
      2310       2320       2330       2340       2350
GMRMQHNLEQ QIQARNTTGV TEEALKEFSM MFKHFDKDKS GRLNHQEFKS 
      2360       2370       2380       2390       2400
CLRSLGYDLP MVEEGEPDPE FEAILDTVDP NRDGHVSLQE YMAFMISRET 
      2410       2420       2430       2440       2450
ENVKSSEEIE SAFRALSSEG KPYVTKEELY QNLTREQADY CVSHMKPYVD 
      2460       2470 
GKGRELPTAF DYVEFTRSLF VN
Length:2,472
Mass (Da):284,539
Last modified:May 2, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4433BF74EFCEFC8A
GO
Isoform 2 (identifier: Q13813-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1586-1586: Q → QLSKLL

Show »
Length:2,477
Mass (Da):285,094
Checksum:i66DC2E2F50E89E1E
GO
Isoform 3 (identifier: Q13813-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1053-1072: Missing.

Show »
Length:2,452
Mass (Da):282,282
Checksum:iA34BBE6ADCAF5A5C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SGF6A0A0D9SGF6_HUMAN
Spectrin alpha chain, non-erythrocy...
SPTAN1
2,498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SF54A0A0D9SF54_HUMAN
Spectrin alpha chain, non-erythrocy...
SPTAN1
2,457Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SFH4A0A0D9SFH4_HUMAN
Spectrin alpha chain, non-erythrocy...
SPTAN1
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUH3A0A1B0GUH3_HUMAN
Spectrin alpha chain, non-erythrocy...
SPTAN1
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTB7A0A1B0GTB7_HUMAN
Spectrin alpha chain, non-erythrocy...
SPTAN1
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTD1A0A1B0GTD1_HUMAN
Spectrin alpha chain, non-erythrocy...
SPTAN1
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SFF6A0A0D9SFF6_HUMAN
Spectrin alpha chain, non-erythrocy...
SPTAN1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GW19A0A1B0GW19_HUMAN
Spectrin alpha chain, non-erythrocy...
SPTAN1
11Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUN2A0A1B0GUN2_HUMAN
Spectrin alpha chain, non-erythrocy...
SPTAN1
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV13A0A1B0GV13_HUMAN
Spectrin alpha chain, non-erythrocy...
SPTAN1
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD93097 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150K → N in AAA51790 (PubMed:2307671).Curated1
Sequence conflicti498S → F in AAA51790 (PubMed:2307671).Curated1
Sequence conflicti737I → V in AAA51790 (PubMed:2307671).Curated1
Sequence conflicti737I → V in AAA52468 (PubMed:3691949).Curated1
Sequence conflicti737I → V in AAA51702 (PubMed:3038643).Curated1
Sequence conflicti1595F → R in AAA52468 (PubMed:3691949).Curated1
Sequence conflicti1595F → R in AAA51702 (PubMed:3038643).Curated1
Sequence conflicti1625S → N in AAA51790 (PubMed:2307671).Curated1
Sequence conflicti1670 – 1671FD → IA in AAA51790 (PubMed:2307671).Curated2
Sequence conflicti1918D → A in AAA51790 (PubMed:2307671).Curated1
Sequence conflicti1971 – 1972KL → NV in AAA51790 (PubMed:2307671).Curated2
Sequence conflicti1971 – 1972KL → NV in AAB41498 (PubMed:10625438).Curated2
Sequence conflicti2163A → R in CAA60503 (PubMed:7607240).Curated1
Sequence conflicti2347 – 2348EF → DG in AAA51790 (PubMed:2307671).Curated2
Sequence conflicti2448Y → I in AAA51790 (PubMed:2307671).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038513385N → S. Corresponds to variant dbSNP:rs2227863EnsemblClinVar.1
Natural variantiVAR_035454904S → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0354551017P → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0122271300I → T3 PublicationsCorresponds to variant dbSNP:rs1048236EnsemblClinVar.1
Natural variantiVAR_0354561794R → W in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0354571918D → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0638862202Missing in EIEE5; could form a heterodimer with SPTBN1 but the heterodimer is thermally unstable; suggests a dominant negative effect. 2 Publications1
Natural variantiVAR_0638872304M → MRM in EIEE5; could form a heterodimer with SPTBN1 but the heterodimer is thermally unstable; suggests a dominant negative effect. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0122711053 – 1072Missing in isoform 3. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_0122701586Q → QLSKLL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J05243 mRNA Translation: AAA51790.1
U83867 mRNA Translation: AAB41498.1
AB191262 mRNA Translation: BAD52438.1
AB209860 mRNA Translation: BAD93097.1 Different initiation.
AL356481 Genomic DNA No translation available.
BC053521 mRNA Translation: AAH53521.1
M24773 mRNA Translation: AAA52468.1
M18627 mRNA Translation: AAA51702.1
U26396 mRNA Translation: AAB60364.1
AF148808 Genomic DNA Translation: AAF26672.1
X86901 mRNA Translation: CAA60503.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS48036.1 [Q13813-2]
CCDS6905.1 [Q13813-1]
CCDS75914.1 [Q13813-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A35715

NCBI Reference Sequences

More...RefSeqi		NP_001123910.1, NM_001130438.2 [Q13813-2]
NP_001182461.1, NM_001195532.1 [Q13813-3]
NP_003118.2, NM_003127.3 [Q13813-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000358161; ENSP00000350882; ENSG00000197694 [Q13813-3]
ENST00000372731; ENSP00000361816; ENSG00000197694 [Q13813-1]
ENST00000372739; ENSP00000361824; ENSG00000197694 [Q13813-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6709

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6709

UCSC genome browser

More...UCSCi		uc004bvl.5, human [Q13813-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05243 mRNA Translation: AAA51790.1
U83867 mRNA Translation: AAB41498.1
AB191262 mRNA Translation: BAD52438.1
AB209860 mRNA Translation: BAD93097.1 Different initiation.
AL356481 Genomic DNA No translation available.
BC053521 mRNA Translation: AAH53521.1
M24773 mRNA Translation: AAA52468.1
M18627 mRNA Translation: AAA51702.1
U26396 mRNA Translation: AAB60364.1
AF148808 Genomic DNA Translation: AAF26672.1
X86901 mRNA Translation: CAA60503.1
CCDSiCCDS48036.1 [Q13813-2]
CCDS6905.1 [Q13813-1]
CCDS75914.1 [Q13813-3]
PIRiA35715
RefSeqiNP_001123910.1, NM_001130438.2 [Q13813-2]
NP_001182461.1, NM_001195532.1 [Q13813-3]
NP_003118.2, NM_003127.3 [Q13813-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FOTX-ray2.45C1172-1211[»]
3F31X-ray2.30A/B1-147[»]
3FB2X-ray2.30A/B1337-1544[»]
5FW9X-ray1.55A965-1025[»]
5FWBX-ray1.50A965-1022[»]
5FWCX-ray1.40A965-1022[»]
BMRBiQ13813
SMRiQ13813
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112587, 234 interactors
CORUMiQ13813
DIPiDIP-33141N
IntActiQ13813, 156 interactors
MINTiQ13813
STRINGi9606.ENSP00000361824

PTM databases

CarbonylDBiQ13813
iPTMnetiQ13813
MetOSiteiQ13813
PhosphoSitePlusiQ13813
SwissPalmiQ13813

Polymorphism and mutation databases

BioMutaiSPTAN1
DMDMi94730425

Proteomic databases

EPDiQ13813
jPOSTiQ13813
MassIVEiQ13813
MaxQBiQ13813
PaxDbiQ13813
PeptideAtlasiQ13813
PRIDEiQ13813
ProteomicsDBi59689 [Q13813-1]
59690 [Q13813-2]
59691 [Q13813-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1910, 454 antibodies

Genome annotation databases

EnsembliENST00000358161; ENSP00000350882; ENSG00000197694 [Q13813-3]
ENST00000372731; ENSP00000361816; ENSG00000197694 [Q13813-1]
ENST00000372739; ENSP00000361824; ENSG00000197694 [Q13813-2]
GeneIDi6709
KEGGihsa:6709
UCSCiuc004bvl.5, human [Q13813-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6709
DisGeNETi6709
EuPathDBiHostDB:ENSG00000197694.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPTAN1
HGNCiHGNC:11273, SPTAN1
HPAiENSG00000197694, Low tissue specificity
MalaCardsiSPTAN1
MIMi182810, gene
613477, phenotype
neXtProtiNX_Q13813
OpenTargetsiENSG00000197694
Orphaneti3451, West syndrome
PharmGKBiPA36102

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0040, Eukaryota
GeneTreeiENSGT00940000156662
HOGENOMiCLU_000847_0_0_1
InParanoidiQ13813
OrthoDBi543832at2759
PhylomeDBiQ13813
TreeFamiTF343803

Enzyme and pathway databases

PathwayCommonsiQ13813
ReactomeiR-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-373753, Nephrin family interactions
R-HSA-375165, NCAM signaling for neurite out-growth
R-HSA-445095, Interaction between L1 and Ankyrins
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6798695, Neutrophil degranulation
R-HSA-6807878, COPI-mediated anterograde transport
SIGNORiQ13813

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6709, 14 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPTAN1, human
EvolutionaryTraceiQ13813

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SPTAN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6709
PharosiQ13813, Tbio

Protein Ontology

More...PROi		PR:Q13813
RNActiQ13813, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197694, Expressed in frontal cortex and 249 other tissues
ExpressionAtlasiQ13813, baseline and differential
GenevisibleiQ13813, HS

Family and domain databases

CDDicd00051, EFh, 1 hit
cd11808, SH3_Alpha_Spectrin, 1 hit
InterProiView protein in InterPro
IPR035825, Alpha_Spectrin_SH3
IPR011992, EF-hand-dom_pair
IPR014837, EF-hand_Ca_insen
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF13499, EF-hand_7, 1 hit
PF08726, EFhand_Ca_insen, 1 hit
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 20 hits
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SM00326, SH3, 1 hit
SM00150, SPEC, 20 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPTN1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13813
Secondary accession number(s): Q13186
, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 2, 2006
Last modified: December 2, 2020
This is version 222 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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