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Protein

Protein Shroom2

Gene

SHROOM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • beta-catenin binding Source: UniProtKB
  • ligand-gated sodium channel activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Shroom2
Alternative name(s):
Apical-like protein
Protein APXL
Gene namesi
Name:SHROOM2
Synonyms:APXL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000146950.12
HGNCiHGNC:630 SHROOM2
MIMi300103 gene
neXtProtiNX_Q13796

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi357
OpenTargetsiENSG00000146950
PharmGKBiPA24916

Polymorphism and mutation databases

BioMutaiSHROOM2
DMDMi2498147

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646501 – 1616Protein Shroom2Add BLAST1616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineBy similarity1
Modified residuei313PhosphoserineBy similarity1
Modified residuei325PhosphoserineBy similarity1
Modified residuei413PhosphoserineCombined sources1
Modified residuei851PhosphoserineCombined sources1
Modified residuei897PhosphoserineBy similarity1
Modified residuei921PhosphoserineBy similarity1
Modified residuei922PhosphoserineBy similarity1
Modified residuei924PhosphoserineBy similarity1
Modified residuei925PhosphothreonineBy similarity1
Modified residuei974PhosphoserineCombined sources1
Modified residuei1036PhosphoserineCombined sources1
Modified residuei1039PhosphoserineCombined sources1
Modified residuei1171PhosphoserineBy similarity1
Modified residuei1173PhosphoserineBy similarity1
Modified residuei1297PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13796
MaxQBiQ13796
PaxDbiQ13796
PeptideAtlasiQ13796
PRIDEiQ13796
ProteomicsDBi59687

PTM databases

iPTMnetiQ13796
PhosphoSitePlusiQ13796

Expressioni

Tissue specificityi

Abundant in retina and melanoma; also in brain, placenta, lung, kidney and pancreas.

Gene expression databases

BgeeiENSG00000146950 Expressed in 169 organ(s), highest expression level in hair follicle
CleanExiHS_SHROOM2
ExpressionAtlasiQ13796 baseline and differential
GenevisibleiQ13796 HS

Organism-specific databases

HPAiHPA051646
HPA061435

Interactioni

Subunit structurei

Interacts with F-actin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1644065,EBI-389883

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106853, 2 interactors
IntActiQ13796, 6 interactors
STRINGi9606.ENSP00000370299

Structurei

Secondary structure

11616
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13796
SMRiQ13796
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 108PDZPROSITE-ProRule annotationAdd BLAST83
Domaini684 – 773ASD1PROSITE-ProRule annotationAdd BLAST90
Domaini1317 – 1611ASD2PROSITE-ProRule annotationAdd BLAST295

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi150 – 153Poly-Ser4
Compositional biasi314 – 320Poly-Pro7
Compositional biasi343 – 346Poly-Ala4
Compositional biasi1065 – 1068Poly-Pro4

Domaini

The ASD1 domain mediates F-actin binding.By similarity

Sequence similaritiesi

Belongs to the shroom family.Curated

Phylogenomic databases

eggNOGiENOG410II86 Eukaryota
ENOG41113GY LUCA
GeneTreeiENSGT00530000063061
HOGENOMiHOG000008235
HOVERGENiHBG096290
InParanoidiQ13796
KOiK18625
OMAiEYQASWK
OrthoDBiEOG091G00F1
PhylomeDBiQ13796
TreeFamiTF333370

Family and domain databases

InterProiView protein in InterPro
IPR014800 ASD1_dom
IPR014799 ASD2_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR027686 Shroom2
IPR027685 Shroom_fam
PANTHERiPTHR15012 PTHR15012, 1 hit
PTHR15012:SF8 PTHR15012:SF8, 1 hit
PfamiView protein in Pfam
PF08688 ASD1, 1 hit
PF08687 ASD2, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51306 ASD1, 1 hit
PS51307 ASD2, 1 hit
PS50106 PDZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q13796-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGAEPRARP ERLAEAETRA ADGGRLVEVQ LSGGAPWGFT LKGGREHGEP
60 70 80 90 100
LVITKIEEGS KAAAVDKLLA GDEIVGINDI GLSGFRQEAI CLVKGSHKTL
110 120 130 140 150
KLVVKRRSEL GWRPHSWHAT KFSDSHPELA ASPFTSTSGC PSWSGRHHAS
160 170 180 190 200
SSSHDLSSSW EQTNLQRTLD HFSSLGSVDS LDHPSSRLSV AKSNSSIDHL
210 220 230 240 250
GSHSKRDSAY GSFSTSSSTP DHTLSKADTS SAENILYTVG LWEAPRQGGR
260 270 280 290 300
QAQAAGDPQG SEEKLSCFPP RVPGDSGKGP RPEYNAEPKL AAPGRSNFGP
310 320 330 340 350
VWYVPDKKKA PSSPPPPPPP LRSDSFAATK SHEKAQGPVF SEAAAAQHFT
360 370 380 390 400
ALAQAQPRGD RRPELTDRPW RSAHPGSLGK GSGGPGCPQE AHADGSWPPS
410 420 430 440 450
KDGASSRLQA SLSSSDVRFP QSPHSGRHPP LYSDHSPLCA DSLGQEPGAA
460 470 480 490 500
SFQNDSPPQV RGLSSCDQKL GSGWQGPRPC VQGDLQAAQL WAGCWPSDTA
510 520 530 540 550
LGALESLPPP TVGQSPRHHL PQPEGPPDAR ETGRCYPLDK GAEGCSAGAQ
560 570 580 590 600
EPPRASRAEK ASQRLAASIT WADGESSRIC PQETPLLHSL TQEGKRRPES
610 620 630 640 650
SPEDSATRPP PFDAHVGKPT RRSDRFATTL RNEIQMHRAK LQKSRSTVAL
660 670 680 690 700
TAAGEAEDGT GRWRAGLGGG TQEGPLAGTY KDHLKEAQAR VLRATSFKRR
710 720 730 740 750
DLDPNPGDLY PESLEHRMGD PDTVPHFWEA GLAQPPSSTS GGPHPPRIGG
760 770 780 790 800
RRRFTAEQKL KSYSEPEKMN EVGLTRGYSP HQHPRTSEDT VGTFADRWKF
810 820 830 840 850
FEETSKPVPQ RPAQKQALHG IPRDKPERPR TAGRTCEGTE PWSRTTSLGD
860 870 880 890 900
SLNAHSAAEK AGTSDLPRRL GTFAEYQASW KEQRKPLEAR SSGRCHSADD
910 920 930 940 950
ILDVSLDPQE RPQHVHGRSR SSPSTDHYKQ EASVELRRQA GDPGEPREEL
960 970 980 990 1000
PSAVRAEEGQ STPRQADAQC REGSPGSQQH PPSQKAPNPP TFSELSHCRG
1010 1020 1030 1040 1050
APELPREGRG RAGTLPRDYR YSEESTPADL GPRAQSPGSP LHARGQDSWP
1060 1070 1080 1090 1100
VSSALLSKRP APQRPPPPKR EPRRYRATDG APADAPVGVL GRPFPTPSPA
1110 1120 1130 1140 1150
SLDVYVARLS LSHSPSVFSS AQPQDTPKAT VCERGSQHVS GDASRPLPEA
1160 1170 1180 1190 1200
LLPPKQQHLR LQTATMETSR SPSPQFAPQK LTDKPPLLIQ DEDSTRIERV
1210 1220 1230 1240 1250
MDNNTTVKMV PIKIVHSESQ PEKESRQSLA CPAEPPALPH GLEKDQIKTL
1260 1270 1280 1290 1300
STSEQFYSRF CLYTRQGAEP EAPHRAQPAE PQPLGTQVPP EKDRCTSPPG
1310 1320 1330 1340 1350
LSYMKAKEKT VEDLKSEELA REIVGKDKSL ADILDPSVKI KTTMDLMEGI
1360 1370 1380 1390 1400
FPKDEHLLEE AQQRRKLLPK IPSPRSTEER KEEPSVPAAV SLATNSTYYS
1410 1420 1430 1440 1450
TSAPKAELLI KMKDLQEQQE HEEDSGSDLD HDLSVKKQEL IESISRKLQV
1460 1470 1480 1490 1500
LREARESLLE DVQANTVLGA EVEAIVKGVC KPSEFDKFRM FIGDLDKVVN
1510 1520 1530 1540 1550
LLLSLSGRLA RVENALNNLD DGASPGDRQS LLEKQRVLIQ QHEDAKELKE
1560 1570 1580 1590 1600
NLDRRERIVF DILANYLSEE SLADYEHFVK MKSALIIEQR ELEDKIHLGE
1610
EQLKCLLDSL QPERGK
Length:1,616
Mass (Da):176,410
Last modified:November 1, 1996 - v1
Checksum:i752406B5BC0B60A2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H3B6F5H3B6_HUMAN
Protein Shroom2
SHROOM2
450Annotation score:
C9IZC6C9IZC6_HUMAN
Protein Shroom2
SHROOM2
375Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053896942D → E. Corresponds to variant dbSNP:rs16985780Ensembl.1
Natural variantiVAR_0365771245D → H in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1033602309Ensembl.1
Natural variantiVAR_0538971475I → V. Corresponds to variant dbSNP:rs12012202Ensembl.1
Natural variantiVAR_0242501607L → F. Corresponds to variant dbSNP:rs2073942Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83543 mRNA Translation: CAA58534.1
AC002365 Genomic DNA Translation: AAC32592.1
AC090481 Genomic DNA No translation available.
BC140866 mRNA Translation: AAI40867.1
CCDSiCCDS14135.1
PIRiI37183
RefSeqiNP_001307592.1, NM_001320663.1
NP_001307593.1, NM_001320664.1
NP_001640.1, NM_001649.3
UniGeneiHs.567236

Genome annotation databases

EnsembliENST00000380913; ENSP00000370299; ENSG00000146950
GeneIDi357
KEGGihsa:357
UCSCiuc004csu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83543 mRNA Translation: CAA58534.1
AC002365 Genomic DNA Translation: AAC32592.1
AC090481 Genomic DNA No translation available.
BC140866 mRNA Translation: AAI40867.1
CCDSiCCDS14135.1
PIRiI37183
RefSeqiNP_001307592.1, NM_001320663.1
NP_001307593.1, NM_001320664.1
NP_001640.1, NM_001649.3
UniGeneiHs.567236

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F4YX-ray3.29A/B1427-1610[»]
5F5PX-ray3.57A/B/G/H1427-1610[»]
ProteinModelPortaliQ13796
SMRiQ13796
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106853, 2 interactors
IntActiQ13796, 6 interactors
STRINGi9606.ENSP00000370299

PTM databases

iPTMnetiQ13796
PhosphoSitePlusiQ13796

Polymorphism and mutation databases

BioMutaiSHROOM2
DMDMi2498147

Proteomic databases

EPDiQ13796
MaxQBiQ13796
PaxDbiQ13796
PeptideAtlasiQ13796
PRIDEiQ13796
ProteomicsDBi59687

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380913; ENSP00000370299; ENSG00000146950
GeneIDi357
KEGGihsa:357
UCSCiuc004csu.2 human

Organism-specific databases

CTDi357
DisGeNETi357
EuPathDBiHostDB:ENSG00000146950.12
GeneCardsiSHROOM2
HGNCiHGNC:630 SHROOM2
HPAiHPA051646
HPA061435
MIMi300103 gene
neXtProtiNX_Q13796
OpenTargetsiENSG00000146950
PharmGKBiPA24916
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II86 Eukaryota
ENOG41113GY LUCA
GeneTreeiENSGT00530000063061
HOGENOMiHOG000008235
HOVERGENiHBG096290
InParanoidiQ13796
KOiK18625
OMAiEYQASWK
OrthoDBiEOG091G00F1
PhylomeDBiQ13796
TreeFamiTF333370

Miscellaneous databases

ChiTaRSiSHROOM2 human
GenomeRNAii357
PROiPR:Q13796
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146950 Expressed in 169 organ(s), highest expression level in hair follicle
CleanExiHS_SHROOM2
ExpressionAtlasiQ13796 baseline and differential
GenevisibleiQ13796 HS

Family and domain databases

InterProiView protein in InterPro
IPR014800 ASD1_dom
IPR014799 ASD2_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR027686 Shroom2
IPR027685 Shroom_fam
PANTHERiPTHR15012 PTHR15012, 1 hit
PTHR15012:SF8 PTHR15012:SF8, 1 hit
PfamiView protein in Pfam
PF08688 ASD1, 1 hit
PF08687 ASD2, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51306 ASD1, 1 hit
PS51307 ASD2, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHRM2_HUMAN
AccessioniPrimary (citable) accession number: Q13796
Secondary accession number(s): B9EIQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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