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Protein

Apolipoprotein F

Gene

APOF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.1 Publication

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

GO - Molecular functioni

  • cholesterol binding Source: ProtInc
  • lipid transporter activity Source: ProtInc
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiR-HSA-8964041 LDL remodeling

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein F
Short name:
Apo-F
Alternative name(s):
Lipid transfer inhibitor protein
Short name:
LTIP
Gene namesi
Name:APOF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000175336.9
HGNCiHGNC:615 APOF
MIMi107760 gene
neXtProtiNX_Q13790

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, LDL, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi319
OpenTargetsiENSG00000175336
PharmGKBiPA24902

Polymorphism and mutation databases

BioMutaiAPOF
DMDMi327478500

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
PropeptideiPRO_000000205136 – 1642 PublicationsAdd BLAST129
ChainiPRO_0000002052165 – 326Apolipoprotein FAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274O-linked (GalNAc...) threonine1 Publication1
Modified residuei323PhosphoserineCombined sources1 Publication1

Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ13790
PeptideAtlasiQ13790
PRIDEiQ13790
ProteomicsDBi59683

PTM databases

GlyConnecti702
iPTMnetiQ13790
PhosphoSitePlusiQ13790
UniCarbKBiQ13790

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.1 Publication

Gene expression databases

BgeeiENSG00000175336 Expressed in 18 organ(s), highest expression level in liver
CleanExiHS_APOF
GenevisibleiQ13790 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106816, 3 interactors
STRINGi9606.ENSP00000381250

Structurei

3D structure databases

ProteinModelPortaliQ13790
SMRiQ13790
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein F family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2UW Eukaryota
ENOG4112458 LUCA
GeneTreeiENSGT00500000045104
HOGENOMiHOG000034007
HOVERGENiHBG050551
InParanoidiQ13790
OMAiVWALQLQ
OrthoDBiEOG091G0O2P
PhylomeDBiQ13790
TreeFamiTF338778

Family and domain databases

InterProiView protein in InterPro
IPR026114 APOF
PANTHERiPTHR15011 PTHR15011, 1 hit
PfamiView protein in Pfam
PF15148 Apolipo_F, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13790-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGLCGYSAP DMRGLRLIMI PVELLLCYLL LHPVDATSYG KQTNVLMHFP
60 70 80 90 100
LSLESQTPSS DPLSCQFLHP KSLPGFSHMA PLPKFLVSLA LRNALEEAGC
110 120 130 140 150
QADVWALQLQ LYRQGGVNAT QVLIQHLRGL QKGRSTERNV SVEALASALQ
160 170 180 190 200
LLAREQQSTG RVGRSLPTED CENEKEQAVH NVVQLLPGVG TFYNLGTALY
210 220 230 240 250
YATQNCLGKA RERGRDGAID LGYDLLMTMA GMSGGPMGLA ISAALKPALR
260 270 280 290 300
SGVQQLIQYY QDQKDANISQ PETTKEGLRA ISDVSDLEET TTLASFISEV
310 320
VSSAPYWGWA IIKSYDLDPG AGSLEI
Length:326
Mass (Da):35,399
Last modified:April 5, 2011 - v2
Checksum:i046A1E775E7D4320
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055520178A → G. Corresponds to variant dbSNP:rs11575216Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27050 mRNA Translation: AAA65642.1
AC025574 Genomic DNA No translation available.
BC026257 mRNA Translation: AAH26257.1
CCDSiCCDS44923.1
PIRiJC2549
RefSeqiNP_001629.1, NM_001638.2
UniGeneiHs.534302

Genome annotation databases

EnsembliENST00000398189; ENSP00000381250; ENSG00000175336
GeneIDi319
KEGGihsa:319
UCSCiuc001sle.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27050 mRNA Translation: AAA65642.1
AC025574 Genomic DNA No translation available.
BC026257 mRNA Translation: AAH26257.1
CCDSiCCDS44923.1
PIRiJC2549
RefSeqiNP_001629.1, NM_001638.2
UniGeneiHs.534302

3D structure databases

ProteinModelPortaliQ13790
SMRiQ13790
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106816, 3 interactors
STRINGi9606.ENSP00000381250

PTM databases

GlyConnecti702
iPTMnetiQ13790
PhosphoSitePlusiQ13790
UniCarbKBiQ13790

Polymorphism and mutation databases

BioMutaiAPOF
DMDMi327478500

Proteomic databases

PaxDbiQ13790
PeptideAtlasiQ13790
PRIDEiQ13790
ProteomicsDBi59683

Protocols and materials databases

DNASUi319
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398189; ENSP00000381250; ENSG00000175336
GeneIDi319
KEGGihsa:319
UCSCiuc001sle.2 human

Organism-specific databases

CTDi319
DisGeNETi319
EuPathDBiHostDB:ENSG00000175336.9
GeneCardsiAPOF
HGNCiHGNC:615 APOF
MIMi107760 gene
neXtProtiNX_Q13790
OpenTargetsiENSG00000175336
PharmGKBiPA24902
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2UW Eukaryota
ENOG4112458 LUCA
GeneTreeiENSGT00500000045104
HOGENOMiHOG000034007
HOVERGENiHBG050551
InParanoidiQ13790
OMAiVWALQLQ
OrthoDBiEOG091G0O2P
PhylomeDBiQ13790
TreeFamiTF338778

Enzyme and pathway databases

ReactomeiR-HSA-8964041 LDL remodeling

Miscellaneous databases

GeneWikiiAPOF
GenomeRNAii319
PROiPR:Q13790
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175336 Expressed in 18 organ(s), highest expression level in liver
CleanExiHS_APOF
GenevisibleiQ13790 HS

Family and domain databases

InterProiView protein in InterPro
IPR026114 APOF
PANTHERiPTHR15011 PTHR15011, 1 hit
PfamiView protein in Pfam
PF15148 Apolipo_F, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPOF_HUMAN
AccessioniPrimary (citable) accession number: Q13790
Secondary accession number(s): Q8TC13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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