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UniProtKB - Q13772 (NCOA4_HUMAN)

Entry version 200 (10 Feb 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Nuclear receptor coactivator 4

Gene

NCOA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei238 – 239Breakpoint for rearrangement to form RET/PTC3 oncogene2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription coactivator activity Source: ProtInc
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13772

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13772

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor coactivator 4
Short name:
NCoA-4
Alternative name(s):
Androgen receptor coactivator 70 kDa protein
Short name:
70 kDa AR-activator
Short name:
70 kDa androgen receptor coactivator
Androgen receptor-associated protein of 70 kDa
Ret-activating protein ELE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCOA4
Synonyms:ARA70, ELE1, RFG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7671, NCOA4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601984, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13772

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000266412.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving NCOA4 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi95 – 96LL → AA: Decreased interaction with PPAR and RXR. 2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		8031

MalaCards human disease database

More...MalaCardsi		NCOA4

Open Targets

More...OpenTargetsi		ENSG00000266412

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		146, Differentiated thyroid carcinoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31473

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13772, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NCOA4

Domain mapping of disease mutations (DMDM)

More...DMDMi		8928226

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000944101 – 614Nuclear receptor coactivator 4Add BLAST614

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13772

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13772

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13772

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13772

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13772

PeptideAtlas

More...PeptideAtlasi		Q13772

PRoteomics IDEntifications database

More...PRIDEi		Q13772

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19088
59681 [Q13772-1]
59682 [Q13772-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13772

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13772

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000266412, Expressed in trabecular bone tissue and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13772, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13772, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000266412, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113726, 41 interactors

Database of interacting proteins

More...DIPi		DIP-5957N

Protein interaction database and analysis system

More...IntActi		Q13772, 21 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000463027

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13772, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1614
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13772

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13772

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQ6V, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008403

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034170_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13772

Identification of Orthologs from Complete Genome Data

More...OMAi		SLSADYH

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13772

TreeFam database of animal gene trees

More...TreeFami		TF333204

Family and domain databases

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00074

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022174, ARA70
IPR039947, NCoA-4

The PANTHER Classification System

More...PANTHERi		PTHR17085, PTHR17085, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12489, ARA70, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: Q13772-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTFQDQSGS SSNREPLLRC SDARRDLELA IGGVLRAEQQ IKDNLREVKA 
        60         70         80         90        100
QIHSCISRHL ECLRSREVWL YEQVDLIYQL KEETLQQQAQ QLYSLLGQFN 
       110        120        130        140        150
CLTHQLECTQ NKDLANQVSV CLERLGSLTL KPEDSTVLLF EADTITLRQT 
       160        170        180        190        200
ITTFGSLKTI QIPEHLMAHA SSANIGPFLE KRGCISMPEQ KSASGIVAVP 
       210        220        230        240        250
FSEWLLGSKP ASGYQAPYIP STDPQDWLTQ KQTLENSQTS SRACNFFNNV 
       260        270        280        290        300
GGNLKGLENW LLKSEKSSYQ KCNSHSTTSS FSIEMEKVGD QELPDQDEMD 
       310        320        330        340        350
LSDWLVTPQE SHKLRKPENG SRETSEKFKL LFQSYNVNDW LVKTDSCTNC 
       360        370        380        390        400
QGNQPKGVEI ENLGNLKCLN DHLEAKKPLS TPSMVTEDWL VQNHQDPCKV 
       410        420        430        440        450
EEVCRANEPC TSFAECVCDE NCEKEALYKW LLKKEGKDKN GMPVEPKPEP 
       460        470        480        490        500
EKHKDSLNMW LCPRKEVIEQ TKAPKAMTPS RIADSFQVIK NSPLSEWLIR 
       510        520        530        540        550
PPYKEGSPKE VPGTEDRAGK QKFKSPMNTS WCSFNTADWV LPGKKMGNLS 
       560        570        580        590        600
QLSSGEDKWL LRKKAQEVLL NSPLQEEHNF PPDHYGLPAV CDLFACMQLK 
       610 
VDKEKWLYRT PLQM
Length:614
Mass (Da):69,726
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36B6D97C7D072BFF
GO
Isoform Beta (identifier: Q13772-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-565: Missing.

Show »
Length:287
Mass (Da):32,562
Checksum:i411914FCC6AD6387
GO
Isoform 3 (identifier: Q13772-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGAQLTTFALAGAVRRM

Show »
Length:630
Mass (Da):71,371
Checksum:iCC77B233C7B8849A
GO
Isoform 4 (identifier: Q13772-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGAQLTTFALAGAVRRM
     614-614: M → AYFKMNFQDVTVGNFQIPCGF

Show »
Length:650
Mass (Da):73,649
Checksum:i504B983AA6E76D83
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DZ85B4DZ85_HUMAN
Nuclear receptor coactivator 4
NCOA4
448Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DF87B4DF87_HUMAN
Nuclear receptor coactivator 4
NCOA4
514Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71Y → H in BAG65022 (PubMed:14702039).Curated1
Sequence conflicti162I → T in CAA50536 (PubMed:8187085).Curated1
Sequence conflicti183G → S in CAA50536 (PubMed:8187085).Curated1
Sequence conflicti271K → R in AK310849 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q13772-3)
Sequence conflicti8F → V in BAG65022 (PubMed:14702039).Curated1
Isoform 4 (identifier: Q13772-4)
Sequence conflicti8F → V in AK310849 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00919094S → L1 PublicationCorresponds to variant dbSNP:rs782517064Ensembl.1
Natural variantiVAR_009191154F → L1 Publication1
Natural variantiVAR_009192350C → R1 Publication1
Natural variantiVAR_014928474P → R. Corresponds to variant dbSNP:rs1132111Ensembl.1
Natural variantiVAR_009193561L → P1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0463481M → MGAQLTTFALAGAVRRM in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_003409239 – 565Missing in isoform Beta. 1 PublicationAdd BLAST327
Alternative sequenceiVSP_046349614M → AYFKMNFQDVTVGNFQIPCG F in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L49399 mRNA Translation: AAC37591.1
X77548 mRNA Translation: CAA54673.1
AK292480 mRNA Translation: BAF85169.1
AK304123 mRNA Translation: BAG65022.1
AK310849 mRNA No translation available.
AL162047 mRNA Translation: CAB82390.1
AL450342 Genomic DNA No translation available.
CH471260 Genomic DNA Translation: EAW53686.1
BC001562 mRNA Translation: AAH01562.1
X71413 mRNA Translation: CAA50536.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS73092.1 [Q13772-1]
CCDS73093.1 [Q13772-3]
CCDS73094.1 [Q13772-4]

Protein sequence database of the Protein Information Resource

More...PIRi		S61532

NCBI Reference Sequences

More...RefSeqi		NP_001138732.1, NM_001145260.1 [Q13772-4]
NP_001138733.1, NM_001145261.1 [Q13772-3]
NP_001138734.1, NM_001145262.1 [Q13772-1]
NP_001138735.1, NM_001145263.1 [Q13772-1]
NP_005428.1, NM_005437.3 [Q13772-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000578454; ENSP00000463027; ENSG00000266412 [Q13772-4]
ENST00000579039; ENSP00000463455; ENSG00000266412 [Q13772-3]
ENST00000581486; ENSP00000462943; ENSG00000266412 [Q13772-1]
ENST00000583565; ENSP00000463476; ENSG00000266412 [Q13772-1]
ENST00000585132; ENSP00000464054; ENSG00000266412 [Q13772-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8031

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8031

UCSC genome browser

More...UCSCi		uc001jis.5, human [Q13772-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49399 mRNA Translation: AAC37591.1
X77548 mRNA Translation: CAA54673.1
AK292480 mRNA Translation: BAF85169.1
AK304123 mRNA Translation: BAG65022.1
AK310849 mRNA No translation available.
AL162047 mRNA Translation: CAB82390.1
AL450342 Genomic DNA No translation available.
CH471260 Genomic DNA Translation: EAW53686.1
BC001562 mRNA Translation: AAH01562.1
X71413 mRNA Translation: CAA50536.1
CCDSiCCDS73092.1 [Q13772-1]
CCDS73093.1 [Q13772-3]
CCDS73094.1 [Q13772-4]
PIRiS61532
RefSeqiNP_001138732.1, NM_001145260.1 [Q13772-4]
NP_001138733.1, NM_001145261.1 [Q13772-3]
NP_001138734.1, NM_001145262.1 [Q13772-1]
NP_001138735.1, NM_001145263.1 [Q13772-1]
NP_005428.1, NM_005437.3 [Q13772-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T5ZX-ray2.30B322-336[»]
SMRiQ13772
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113726, 41 interactors
DIPiDIP-5957N
IntActiQ13772, 21 interactors
STRINGi9606.ENSP00000463027

PTM databases

iPTMnetiQ13772
PhosphoSitePlusiQ13772

Genetic variation databases

BioMutaiNCOA4
DMDMi8928226

Proteomic databases

EPDiQ13772
jPOSTiQ13772
MassIVEiQ13772
MaxQBiQ13772
PaxDbiQ13772
PeptideAtlasiQ13772
PRIDEiQ13772
ProteomicsDBi19088
59681 [Q13772-1]
59682 [Q13772-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		72715, 390 antibodies

The DNASU plasmid repository

More...DNASUi		8031

Genome annotation databases

EnsembliENST00000578454; ENSP00000463027; ENSG00000266412 [Q13772-4]
ENST00000579039; ENSP00000463455; ENSG00000266412 [Q13772-3]
ENST00000581486; ENSP00000462943; ENSG00000266412 [Q13772-1]
ENST00000583565; ENSP00000463476; ENSG00000266412 [Q13772-1]
ENST00000585132; ENSP00000464054; ENSG00000266412 [Q13772-1]
GeneIDi8031
KEGGihsa:8031
UCSCiuc001jis.5, human [Q13772-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8031
DisGeNETi8031

GeneCards: human genes, protein and diseases

More...GeneCardsi		NCOA4
HGNCiHGNC:7671, NCOA4
HPAiENSG00000266412, Tissue enhanced (blood)
MalaCardsiNCOA4
MIMi601984, gene
neXtProtiNX_Q13772
OpenTargetsiENSG00000266412
Orphaneti146, Differentiated thyroid carcinoma
PharmGKBiPA31473
VEuPathDBiHostDB:ENSG00000266412.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQ6V, Eukaryota
GeneTreeiENSGT00390000008403
HOGENOMiCLU_034170_0_0_1
InParanoidiQ13772
OMAiSLSADYH
PhylomeDBiQ13772
TreeFamiTF333204

Enzyme and pathway databases

PathwayCommonsiQ13772
SIGNORiQ13772

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8031, 142 hits in 888 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NCOA4, human
EvolutionaryTraceiQ13772

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NCOA4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8031
PharosiQ13772, Tbio

Protein Ontology

More...PROi		PR:Q13772
RNActiQ13772, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000266412, Expressed in trabecular bone tissue and 251 other tissues
ExpressionAtlasiQ13772, baseline and differential
GenevisibleiQ13772, HS

Family and domain databases

IDEALiIID00074
InterProiView protein in InterPro
IPR022174, ARA70
IPR039947, NCoA-4
PANTHERiPTHR17085, PTHR17085, 1 hit
PfamiView protein in Pfam
PF12489, ARA70, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOA4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13772
Secondary accession number(s): A8K8W5
, B4E260, E9PAV7, J3KQN8, Q14239
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: February 10, 2021
This is version 200 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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