UniProtKB - Q13772 (NCOA4_HUMAN)
Protein
Nuclear receptor coactivator 4
Gene
NCOA4
Organism
Homo sapiens (Human)
Status
Functioni
Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 238 – 239 | Breakpoint for rearrangement to form RET/PTC3 oncogene | 2 |
GO - Molecular functioni
- transcription coactivator activity Source: ProtInc
GO - Biological processi
- cellular iron ion homeostasis Source: Ensembl
- cellular response to estrogen stimulus Source: ARUK-UCL
- cellular response to testosterone stimulus Source: ARUK-UCL
- intracellular estrogen receptor signaling pathway Source: ARUK-UCL
- male gonad development Source: ProtInc
- protein targeting to lysosome Source: MGI
- response to hormone Source: GO_Central
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q13772 |
SIGNORi | Q13772 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor coactivator 4Short name: NCoA-4 Alternative name(s): Androgen receptor coactivator 70 kDa protein Short name: 70 kDa AR-activator Short name: 70 kDa androgen receptor coactivator Androgen receptor-associated protein of 70 kDa Ret-activating protein ELE1 |
Gene namesi | Name:NCOA4 Synonyms:ARA70, ELE1, RFG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7671, NCOA4 |
MIMi | 601984, gene |
neXtProti | NX_Q13772 |
VEuPathDBi | HostDB:ENSG00000266412.5 |
Subcellular locationi
Lysosome
- autolysosome Source: MGI
Nucleus
- nucleus Source: ProtInc
Pathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving NCOA4 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene.2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 95 – 96 | LL → AA: Decreased interaction with PPAR and RXR. | 2 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 8031 |
MalaCardsi | NCOA4 |
OpenTargetsi | ENSG00000266412 |
Orphaneti | 146, Differentiated thyroid carcinoma |
PharmGKBi | PA31473 |
Miscellaneous databases
Pharosi | Q13772, Tbio |
Genetic variation databases
BioMutai | NCOA4 |
DMDMi | 8928226 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094410 | 1 – 614 | Nuclear receptor coactivator 4Add BLAST | 614 |
Proteomic databases
EPDi | Q13772 |
jPOSTi | Q13772 |
MassIVEi | Q13772 |
MaxQBi | Q13772 |
PaxDbi | Q13772 |
PeptideAtlasi | Q13772 |
PRIDEi | Q13772 |
ProteomicsDBi | 19088 59681 [Q13772-1] 59682 [Q13772-2] |
PTM databases
iPTMneti | Q13772 |
PhosphoSitePlusi | Q13772 |
Expressioni
Tissue specificityi
Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.
Gene expression databases
Bgeei | ENSG00000266412, Expressed in trabecular bone tissue and 251 other tissues |
ExpressionAtlasi | Q13772, baseline and differential |
Genevisiblei | Q13772, HS |
Organism-specific databases
HPAi | ENSG00000266412, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner.
Binary interactionsi
Hide detailsIsoform 3 [Q13772-3]
With | #Exp. | IntAct |
---|---|---|
ATXN10 [Q9UBB4] | 3 | EBI-12054609,EBI-702390 |
JPH3 [Q8WXH2] | 3 | EBI-12054609,EBI-1055254 |
MID2 - isoform 2 [Q9UJV3-2] | 3 | EBI-12054609,EBI-10172526 |
Protein-protein interaction databases
BioGRIDi | 113726, 41 interactors |
DIPi | DIP-5957N |
IntActi | Q13772, 21 interactors |
STRINGi | 9606.ENSP00000463027 |
Miscellaneous databases
RNActi | Q13772, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q13772 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13772 |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502QQ6V, Eukaryota |
GeneTreei | ENSGT00390000008403 |
HOGENOMi | CLU_034170_0_0_1 |
InParanoidi | Q13772 |
OMAi | SLSADYH |
PhylomeDBi | Q13772 |
TreeFami | TF333204 |
Family and domain databases
IDEALi | IID00074 |
InterProi | View protein in InterPro IPR022174, ARA70 IPR039947, NCoA-4 |
PANTHERi | PTHR17085, PTHR17085, 1 hit |
Pfami | View protein in Pfam PF12489, ARA70, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketNote: Additional isoforms seem to exist.
This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform Alpha (identifier: Q13772-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNTFQDQSGS SSNREPLLRC SDARRDLELA IGGVLRAEQQ IKDNLREVKA
60 70 80 90 100
QIHSCISRHL ECLRSREVWL YEQVDLIYQL KEETLQQQAQ QLYSLLGQFN
110 120 130 140 150
CLTHQLECTQ NKDLANQVSV CLERLGSLTL KPEDSTVLLF EADTITLRQT
160 170 180 190 200
ITTFGSLKTI QIPEHLMAHA SSANIGPFLE KRGCISMPEQ KSASGIVAVP
210 220 230 240 250
FSEWLLGSKP ASGYQAPYIP STDPQDWLTQ KQTLENSQTS SRACNFFNNV
260 270 280 290 300
GGNLKGLENW LLKSEKSSYQ KCNSHSTTSS FSIEMEKVGD QELPDQDEMD
310 320 330 340 350
LSDWLVTPQE SHKLRKPENG SRETSEKFKL LFQSYNVNDW LVKTDSCTNC
360 370 380 390 400
QGNQPKGVEI ENLGNLKCLN DHLEAKKPLS TPSMVTEDWL VQNHQDPCKV
410 420 430 440 450
EEVCRANEPC TSFAECVCDE NCEKEALYKW LLKKEGKDKN GMPVEPKPEP
460 470 480 490 500
EKHKDSLNMW LCPRKEVIEQ TKAPKAMTPS RIADSFQVIK NSPLSEWLIR
510 520 530 540 550
PPYKEGSPKE VPGTEDRAGK QKFKSPMNTS WCSFNTADWV LPGKKMGNLS
560 570 580 590 600
QLSSGEDKWL LRKKAQEVLL NSPLQEEHNF PPDHYGLPAV CDLFACMQLK
610
VDKEKWLYRT PLQM
Isoform Beta (identifier: Q13772-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
239-565: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DZ85 | B4DZ85_HUMAN | Nuclear receptor coactivator 4 | NCOA4 | 448 | Annotation score: | ||
B4DF87 | B4DF87_HUMAN | Nuclear receptor coactivator 4 | NCOA4 | 514 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 71 | Y → H in BAG65022 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 162 | I → T in CAA50536 (PubMed:8187085).Curated | 1 | ||
Sequence conflicti | 183 | G → S in CAA50536 (PubMed:8187085).Curated | 1 | ||
Sequence conflicti | 271 | K → R in AK310849 (PubMed:14702039).Curated | 1 | ||
Isoform 3 (identifier: Q13772-3) | |||||
Sequence conflicti | 8 | F → V in BAG65022 (PubMed:14702039).Curated | 1 | ||
Isoform 4 (identifier: Q13772-4) | |||||
Sequence conflicti | 8 | F → V in AK310849 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_009190 | 94 | S → L1 PublicationCorresponds to variant dbSNP:rs782517064Ensembl. | 1 | |
Natural variantiVAR_009191 | 154 | F → L1 Publication | 1 | |
Natural variantiVAR_009192 | 350 | C → R1 Publication | 1 | |
Natural variantiVAR_014928 | 474 | P → R. Corresponds to variant dbSNP:rs1132111Ensembl. | 1 | |
Natural variantiVAR_009193 | 561 | L → P1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046348 | 1 | M → MGAQLTTFALAGAVRRM in isoform 3 and isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_003409 | 239 – 565 | Missing in isoform Beta. 1 PublicationAdd BLAST | 327 | |
Alternative sequenceiVSP_046349 | 614 | M → AYFKMNFQDVTVGNFQIPCG F in isoform 4. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49399 mRNA Translation: AAC37591.1 X77548 mRNA Translation: CAA54673.1 AK292480 mRNA Translation: BAF85169.1 AK304123 mRNA Translation: BAG65022.1 AK310849 mRNA No translation available. AL162047 mRNA Translation: CAB82390.1 AL450342 Genomic DNA No translation available. CH471260 Genomic DNA Translation: EAW53686.1 BC001562 mRNA Translation: AAH01562.1 X71413 mRNA Translation: CAA50536.1 |
CCDSi | CCDS73092.1 [Q13772-1] CCDS73093.1 [Q13772-3] CCDS73094.1 [Q13772-4] |
PIRi | S61532 |
RefSeqi | NP_001138732.1, NM_001145260.1 [Q13772-4] NP_001138733.1, NM_001145261.1 [Q13772-3] NP_001138734.1, NM_001145262.1 [Q13772-1] NP_001138735.1, NM_001145263.1 [Q13772-1] NP_005428.1, NM_005437.3 [Q13772-1] |
Genome annotation databases
Ensembli | ENST00000578454; ENSP00000463027; ENSG00000266412 [Q13772-4] ENST00000579039; ENSP00000463455; ENSG00000266412 [Q13772-3] ENST00000581486; ENSP00000462943; ENSG00000266412 [Q13772-1] ENST00000583565; ENSP00000463476; ENSG00000266412 [Q13772-1] ENST00000585132; ENSP00000464054; ENSG00000266412 [Q13772-1] |
GeneIDi | 8031 |
KEGGi | hsa:8031 |
UCSCi | uc001jis.5, human [Q13772-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49399 mRNA Translation: AAC37591.1 X77548 mRNA Translation: CAA54673.1 AK292480 mRNA Translation: BAF85169.1 AK304123 mRNA Translation: BAG65022.1 AK310849 mRNA No translation available. AL162047 mRNA Translation: CAB82390.1 AL450342 Genomic DNA No translation available. CH471260 Genomic DNA Translation: EAW53686.1 BC001562 mRNA Translation: AAH01562.1 X71413 mRNA Translation: CAA50536.1 |
CCDSi | CCDS73092.1 [Q13772-1] CCDS73093.1 [Q13772-3] CCDS73094.1 [Q13772-4] |
PIRi | S61532 |
RefSeqi | NP_001138732.1, NM_001145260.1 [Q13772-4] NP_001138733.1, NM_001145261.1 [Q13772-3] NP_001138734.1, NM_001145262.1 [Q13772-1] NP_001138735.1, NM_001145263.1 [Q13772-1] NP_005428.1, NM_005437.3 [Q13772-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1T5Z | X-ray | 2.30 | B | 322-336 | [»] | |
SMRi | Q13772 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113726, 41 interactors |
DIPi | DIP-5957N |
IntActi | Q13772, 21 interactors |
STRINGi | 9606.ENSP00000463027 |
PTM databases
iPTMneti | Q13772 |
PhosphoSitePlusi | Q13772 |
Genetic variation databases
BioMutai | NCOA4 |
DMDMi | 8928226 |
Proteomic databases
EPDi | Q13772 |
jPOSTi | Q13772 |
MassIVEi | Q13772 |
MaxQBi | Q13772 |
PaxDbi | Q13772 |
PeptideAtlasi | Q13772 |
PRIDEi | Q13772 |
ProteomicsDBi | 19088 59681 [Q13772-1] 59682 [Q13772-2] |
Protocols and materials databases
Antibodypediai | 72715, 390 antibodies |
DNASUi | 8031 |
Genome annotation databases
Ensembli | ENST00000578454; ENSP00000463027; ENSG00000266412 [Q13772-4] ENST00000579039; ENSP00000463455; ENSG00000266412 [Q13772-3] ENST00000581486; ENSP00000462943; ENSG00000266412 [Q13772-1] ENST00000583565; ENSP00000463476; ENSG00000266412 [Q13772-1] ENST00000585132; ENSP00000464054; ENSG00000266412 [Q13772-1] |
GeneIDi | 8031 |
KEGGi | hsa:8031 |
UCSCi | uc001jis.5, human [Q13772-1] |
Organism-specific databases
CTDi | 8031 |
DisGeNETi | 8031 |
GeneCardsi | NCOA4 |
HGNCi | HGNC:7671, NCOA4 |
HPAi | ENSG00000266412, Tissue enhanced (blood) |
MalaCardsi | NCOA4 |
MIMi | 601984, gene |
neXtProti | NX_Q13772 |
OpenTargetsi | ENSG00000266412 |
Orphaneti | 146, Differentiated thyroid carcinoma |
PharmGKBi | PA31473 |
VEuPathDBi | HostDB:ENSG00000266412.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ6V, Eukaryota |
GeneTreei | ENSGT00390000008403 |
HOGENOMi | CLU_034170_0_0_1 |
InParanoidi | Q13772 |
OMAi | SLSADYH |
PhylomeDBi | Q13772 |
TreeFami | TF333204 |
Enzyme and pathway databases
PathwayCommonsi | Q13772 |
SIGNORi | Q13772 |
Miscellaneous databases
BioGRID-ORCSi | 8031, 142 hits in 888 CRISPR screens |
ChiTaRSi | NCOA4, human |
EvolutionaryTracei | Q13772 |
GeneWikii | NCOA4 |
GenomeRNAii | 8031 |
Pharosi | Q13772, Tbio |
PROi | PR:Q13772 |
RNActi | Q13772, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000266412, Expressed in trabecular bone tissue and 251 other tissues |
ExpressionAtlasi | Q13772, baseline and differential |
Genevisiblei | Q13772, HS |
Family and domain databases
IDEALi | IID00074 |
InterProi | View protein in InterPro IPR022174, ARA70 IPR039947, NCoA-4 |
PANTHERi | PTHR17085, PTHR17085, 1 hit |
Pfami | View protein in Pfam PF12489, ARA70, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NCOA4_HUMAN | |
Accessioni | Q13772Primary (citable) accession number: Q13772 Secondary accession number(s): A8K8W5 Q14239 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 200 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references