UniProtKB - Q13769 (THOC5_HUMAN)
THO complex subunit 5 homolog
THOC5
Functioni
GO - Molecular functioni
- mRNA binding Source: GO_Central
GO - Biological processi
- monocyte differentiation Source: UniProtKB
- mRNA 3'-end processing Source: Reactome
- mRNA export from nucleus Source: UniProtKB
- negative regulation of DNA damage checkpoint Source: UniProtKB
- positive regulation of DNA-templated transcription, elongation Source: UniProtKB
- primitive hemopoiesis Source: UniProtKB
- RNA export from nucleus Source: Reactome
- RNA splicing Source: UniProtKB-KW
- viral mRNA export from host cell nucleus Source: UniProtKB
Keywordsi
Molecular function | RNA-binding |
Biological process | Differentiation, mRNA processing, mRNA splicing, mRNA transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q13769 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
SIGNORi | Q13769 |
Names & Taxonomyi
Protein namesi | Recommended name: THO complex subunit 5 homologAlternative name(s): Functional spliceosome-associated protein 79 Short name: fSAP79 NF2/meningioma region protein pK1.3 Placental protein 39.2 Short name: PP39.2 hTREX90 |
Gene namesi | Name:THOC5 Synonyms:C22orf19, KIAA0983 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19074, THOC5 |
MIMi | 612733, gene |
neXtProti | NX_Q13769 |
VEuPathDBi | HostDB:ENSG00000100296.13 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- THO complex Source: UniProtKB
- THO complex part of transcription export complex Source: UniProtKB
- transcription export complex Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 225 | Y → F: Impairs mRNA binding, enhances CXCL12-dependent cell migration. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8563 |
OpenTargetsi | ENSG00000100296 |
PharmGKBi | PA38188 |
Miscellaneous databases
Pharosi | Q13769, Tbio |
Genetic variation databases
BioMutai | THOC5 |
DMDMi | 259016156 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000079577 | 2 – 683 | THO complex subunit 5 homologAdd BLAST | 682 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 5 | PhosphoserineBy similarity | 1 | |
Modified residuei | 6 | PhosphoserineBy similarity | 1 | |
Cross-linki | 153 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 225 | Phosphotyrosine; by SRC2 Publications | 1 | |
Modified residuei | 307 | PhosphoserineCombined sources | 1 | |
Modified residuei | 312 | PhosphoserineCombined sources | 1 | |
Modified residuei | 314 | PhosphoserineCombined sources | 1 | |
Modified residuei | 328 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q13769 |
jPOSTi | Q13769 |
MassIVEi | Q13769 |
MaxQBi | Q13769 |
PaxDbi | Q13769 |
PeptideAtlasi | Q13769 |
PRIDEi | Q13769 |
ProteomicsDBi | 59680 |
PTM databases
iPTMneti | Q13769 |
MetOSitei | Q13769 |
PhosphoSitePlusi | Q13769 |
SwissPalmi | Q13769 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000100296, Expressed in fundus of stomach and 229 other tissues |
ExpressionAtlasi | Q13769, baseline and differential |
Genevisiblei | Q13769, HS |
Organism-specific databases
HPAi | ENSG00000100296, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with phosphorylated CSF1R (By similarity).
Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.
Interacts with ALYREF/THOC4, and THOC7.
Interacts (via N-terminus) with the NTF2 domain of NXF1.
Forms a complex with CEBPB.
Interacts with CPSF6; indicative for an association with the cleavage factor Im (CFIm) complex.
Interacts with THOC1 (By similarity).
Interacts with LUZP4.
Interacts with NCBP3 (PubMed:26382858).
By similarity8 PublicationsBinary interactionsi
Hide detailsQ13769
With | #Exp. | IntAct |
---|---|---|
TAP1 [Q03518] | 4 | EBI-5280316,EBI-747259 |
THOC1 [Q96FV9] | 10 | EBI-5280316,EBI-1765605 |
THOC7 [Q6I9Y2] | 9 | EBI-5280316,EBI-716286 |
Protein-protein interaction databases
BioGRIDi | 114132, 79 interactors |
CORUMi | Q13769 |
IntActi | Q13769, 58 interactors |
MINTi | Q13769 |
STRINGi | 9606.ENSP00000420306 |
Miscellaneous databases
RNActi | Q13769, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 199 | Interaction with THOC71 PublicationAdd BLAST | 198 | |
Regioni | 2 – 144 | Interaction with CSF1RBy similarityAdd BLAST | 143 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 7 – 10 | Nuclear localization signalBy similarity | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2216, Eukaryota |
GeneTreei | ENSGT00390000013777 |
HOGENOMi | CLU_023759_1_0_1 |
InParanoidi | Q13769 |
OMAi | WNGCHTS |
OrthoDBi | 1048314at2759 |
PhylomeDBi | Q13769 |
TreeFami | TF314812 |
Family and domain databases
InterProi | View protein in InterPro IPR019163, THO_Thoc5 |
PANTHERi | PTHR13375, PTHR13375, 1 hit |
Pfami | View protein in Pfam PF09766, FmiP_Thoc5, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSSESSKKRK PKVIRSDGAP AEGKRNRSDT EQEGKYYSEE AEVDLRDPGR
60 70 80 90 100
DYELYKYTCQ ELQRLMAEIQ DLKSRGGKDV AIEIEERRIQ SCVHFMTLKK
110 120 130 140 150
LNRLAHIRLK KGRDQTHEAK QKVDAYHLQL QNLLYEVMHL QKEITKCLEF
160 170 180 190 200
KSKHEEIDLV SLEEFYKEAP PDISKAEVTM GDPHQQTLAR LDWELEQRKR
210 220 230 240 250
LAEKYRECLS NKEKILKEIE VKKEYLSSLQ PRLNSIMQAS LPVQEYLFMP
260 270 280 290 300
FDQAHKQYET ARHLPPPLYV LFVQATAYGQ ACDKTLSVAI EGSVDEAKAL
310 320 330 340 350
FKPPEDSQDD ESDSDAEEEQ TTKRRRPTLG VQLDDKRKEM LKRHPLSVML
360 370 380 390 400
DLKCKDDSVL HLTFYYLMNL NIMTVKAKVT TAMELITPIS AGDLLSPDSV
410 420 430 440 450
LSCLYPGDHG KKTPNPANQY QFDKVGILTL SDYVLELGHP YLWVQKLGGL
460 470 480 490 500
HFPKEQPQQT VIADHSLSAS HMETTMKLLK TRVQSRLALH KQFASLEHGI
510 520 530 540 550
VPVTSDCQYL FPAKVVSRLV KWVTVAHEDY MELHFTKDIV DAGLAGDTNL
560 570 580 590 600
YYMALIERGT AKLQAAVVLN PGYSSIPPVF QLCLNWKGEK TNSNDDNIRA
610 620 630 640 650
MEGEVNVCYK ELCGPWPSHQ LLTNQLQRLC VLLDVYLETE SHDDSVEGPK
660 670 680
EFPQEKMCLR LFRGPSRMKP FKYNHPQGFF SHR
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C072 | H7C072_HUMAN | THO complex subunit 5 homolog | THOC5 | 262 | Annotation score: | ||
F8WCP5 | F8WCP5_HUMAN | THO complex subunit 5 homolog | THOC5 | 343 | Annotation score: | ||
C9JCL9 | C9JCL9_HUMAN | THO complex subunit 5 homolog | THOC5 | 161 | Annotation score: | ||
C9JXG5 | C9JXG5_HUMAN | THO complex subunit 5 homolog | THOC5 | 223 | Annotation score: | ||
H7C441 | H7C441_HUMAN | THO complex subunit 5 homolog | THOC5 | 176 | Annotation score: | ||
F5GZF3 | F5GZF3_HUMAN | THO complex subunit 5 homolog | THOC5 | 127 | Annotation score: | ||
C9JXU6 | C9JXU6_HUMAN | THO complex subunit 5 homolog | THOC5 | 93 | Annotation score: | ||
F8WES8 | F8WES8_HUMAN | THO complex subunit 5 homolog | THOC5 | 43 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035692 | 380 | T → K in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1264823745Ensembl. | 1 | |
Natural variantiVAR_037134 | 475 | T → S. Corresponds to variant dbSNP:rs8141153Ensembl. | 1 | |
Natural variantiVAR_035693 | 499 | G → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1280359906Ensembl. | 1 | |
Natural variantiVAR_037135 | 525 | V → I4 PublicationsCorresponds to variant dbSNP:rs737976Ensembl. | 1 | |
Natural variantiVAR_021410 | 579 | V → I3 PublicationsCorresponds to variant dbSNP:rs1049534Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L18972 Genomic DNA Translation: AAC26837.1 AB023200 mRNA Translation: BAA76827.2 Different initiation. CR456542 mRNA Translation: CAG30428.1 AC005529 Genomic DNA No translation available. BC003615 mRNA Translation: AAH03615.1 AJ006069 mRNA Translation: CAA06841.1 |
CCDSi | CCDS13859.1 |
PIRi | I39463 |
RefSeqi | NP_001002877.1, NM_001002877.1 NP_001002878.1, NM_001002878.1 NP_001002879.1, NM_001002879.1 NP_003669.4, NM_003678.4 |
Genome annotation databases
Ensembli | ENST00000397871; ENSP00000380969; ENSG00000100296 ENST00000397872; ENSP00000380970; ENSG00000100296 ENST00000397873; ENSP00000380971; ENSG00000100296 ENST00000490103; ENSP00000420306; ENSG00000100296 |
GeneIDi | 8563 |
KEGGi | hsa:8563 |
UCSCi | uc003afr.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L18972 Genomic DNA Translation: AAC26837.1 AB023200 mRNA Translation: BAA76827.2 Different initiation. CR456542 mRNA Translation: CAG30428.1 AC005529 Genomic DNA No translation available. BC003615 mRNA Translation: AAH03615.1 AJ006069 mRNA Translation: CAA06841.1 |
CCDSi | CCDS13859.1 |
PIRi | I39463 |
RefSeqi | NP_001002877.1, NM_001002877.1 NP_001002878.1, NM_001002878.1 NP_001002879.1, NM_001002879.1 NP_003669.4, NM_003678.4 |
3D structure databases
SMRi | Q13769 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114132, 79 interactors |
CORUMi | Q13769 |
IntActi | Q13769, 58 interactors |
MINTi | Q13769 |
STRINGi | 9606.ENSP00000420306 |
PTM databases
iPTMneti | Q13769 |
MetOSitei | Q13769 |
PhosphoSitePlusi | Q13769 |
SwissPalmi | Q13769 |
Genetic variation databases
BioMutai | THOC5 |
DMDMi | 259016156 |
Proteomic databases
EPDi | Q13769 |
jPOSTi | Q13769 |
MassIVEi | Q13769 |
MaxQBi | Q13769 |
PaxDbi | Q13769 |
PeptideAtlasi | Q13769 |
PRIDEi | Q13769 |
ProteomicsDBi | 59680 |
Protocols and materials databases
Antibodypediai | 24518, 191 antibodies |
DNASUi | 8563 |
Genome annotation databases
Ensembli | ENST00000397871; ENSP00000380969; ENSG00000100296 ENST00000397872; ENSP00000380970; ENSG00000100296 ENST00000397873; ENSP00000380971; ENSG00000100296 ENST00000490103; ENSP00000420306; ENSG00000100296 |
GeneIDi | 8563 |
KEGGi | hsa:8563 |
UCSCi | uc003afr.4, human |
Organism-specific databases
CTDi | 8563 |
DisGeNETi | 8563 |
GeneCardsi | THOC5 |
HGNCi | HGNC:19074, THOC5 |
HPAi | ENSG00000100296, Low tissue specificity |
MIMi | 612733, gene |
neXtProti | NX_Q13769 |
OpenTargetsi | ENSG00000100296 |
PharmGKBi | PA38188 |
VEuPathDBi | HostDB:ENSG00000100296.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2216, Eukaryota |
GeneTreei | ENSGT00390000013777 |
HOGENOMi | CLU_023759_1_0_1 |
InParanoidi | Q13769 |
OMAi | WNGCHTS |
OrthoDBi | 1048314at2759 |
PhylomeDBi | Q13769 |
TreeFami | TF314812 |
Enzyme and pathway databases
PathwayCommonsi | Q13769 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
SIGNORi | Q13769 |
Miscellaneous databases
BioGRID-ORCSi | 8563, 707 hits in 884 CRISPR screens |
ChiTaRSi | THOC5, human |
GeneWikii | THOC5 |
GenomeRNAii | 8563 |
Pharosi | Q13769, Tbio |
PROi | PR:Q13769 |
RNActi | Q13769, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100296, Expressed in fundus of stomach and 229 other tissues |
ExpressionAtlasi | Q13769, baseline and differential |
Genevisiblei | Q13769, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019163, THO_Thoc5 |
PANTHERi | PTHR13375, PTHR13375, 1 hit |
Pfami | View protein in Pfam PF09766, FmiP_Thoc5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THOC5_HUMAN | |
Accessioni | Q13769Primary (citable) accession number: Q13769 Secondary accession number(s): O60839, Q9UPZ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | September 22, 2009 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families