NACA

Functionⁱ

Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.3 Publications

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
transcription coactivator activity
Source: BHF-UCL
Non-traceable author statementⁱ
- 21071677

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac ventricle development Source: BHF-UCL
heart trabecula morphogenesis Source: BHF-UCL
negative regulation of striated muscle cell apoptotic process Source: BHF-UCL
negative regulation of transcription from RNA polymerase II promoter involved in heart development Source: BHF-UCL
positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
positive regulation of skeletal muscle tissue growth Source: BHF-UCL
positive regulation of transcription from RNA polymerase II promoter involved in heart development Source: BHF-UCL
protein transport Source: UniProtKB-KW
regulation of skeletal muscle fiber development Source: BHF-UCL
skeletal muscle tissue regeneration Source: BHF-UCL
translation
Source: ProtInc
Traceable author statementⁱ
- 8047162

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone, DNA-binding
Biological process	Protein transport, Transcription, Transport

Enzyme and pathway databases

SIGNORⁱ	Q13765

SIGNORⁱ

Q13765

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nascent polypeptide-associated complex subunit alpha Short name: NAC-alpha Alternative name(s): Alpha-NAC Allergen: Hom s 2
Gene namesⁱ	Name:NACA ORF Names:HSD48
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196531.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7629 NACA
MIMⁱ	601234 gene
neXtProtⁱ	NX_Q13765

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Allergenic propertiesⁱ

Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.1 Publication

Keywords - Diseaseⁱ

Allergen

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4666
Open Targets More...OpenTargetsⁱ	ENSG00000196531
PharmGKBⁱ	PA31433

Protein family/group databases

Allergomeⁱ	3323 Hom s 2.0101 412 Hom s 2

Allergomeⁱ

3323 Hom s 2.0101
412 Hom s 2

Polymorphism and mutation databases

BioMutaⁱ	NACA
DMDMⁱ	71151996

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000135576	1 – 215	Nascent polypeptide-associated complex subunit alphaAdd BLAST		215

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	43	Phosphoserine; by ILK11 Publication	1
Modified residueⁱ	132	PhosphoserineCombined sources	1
Modified residueⁱ	142	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	142	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	159	Phosphothreonine; by GSK3-betaBy similarity	1
Modified residueⁱ	161	PhosphothreonineCombined sources	1
Modified residueⁱ	166	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	186	PhosphoserineCombined sources	1
Modified residueⁱ	191	PhosphoserineCombined sources	1
Modified residueⁱ	203	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation (By similarity). Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization.By similarity2 Publications

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q13765
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13765
PeptideAtlas More...PeptideAtlasⁱ	Q13765
PRIDEⁱ	Q13765
ProteomicsDBⁱ	59679
TopDownProteomicsⁱ	Q13765-1 [Q13765-1]

PTM databases

iPTMnetⁱ	Q13765
SwissPalmⁱ	Q13765

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000196531 Expressed in 241 organ(s), highest expression level in testis
CleanExⁱ	HS_NACA
ExpressionAtlasⁱ	Q13765 baseline and differential
Genevisibleⁱ	Q13765 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA073152 HPA073648

HPAⁱ

HPA073152
HPA073648

Interactionⁱ

Subunit structureⁱ

Interacts with TBP and JUN (By similarity). Part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of NACA and BTF3 (via NAC-A/B domains). NAC associates with ribosomes through the BTF3/NACB subunit and contacts the ribosomal protein L23, which is positioned near the exiting site. Both subunits can contact nascent polypeptide chains. NACA may also form homodimers, and only this form binds DNA.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TXLNA	P40222	2	EBI-712216,EBI-359793

With

Entry

#Exp.

IntAct

Notes

TXLNA

P40222

2

EBI-712216,EBI-359793

Protein-protein interaction databases

BioGridⁱ	110748, 59 interactors
Database of interacting proteins More...DIPⁱ	DIP-43878N
IntActⁱ	Q13765, 31 interactors
Molecular INTeraction database More...MINTⁱ	Q13765

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	80 – 83	Combined sources	4
Beta strandⁱ	86 – 88	Combined sources	3
Beta strandⁱ	91 – 108	Combined sources	18
Beta strandⁱ	110 – 113	Combined sources	4
Beta strandⁱ	117 – 124	Combined sources	8
Beta strandⁱ	126 – 130	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13765
SMRⁱ	Q13765
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13765

EvolutionaryTraceⁱ

Q13765

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	70 – 135	NAC-A/BPROSITE-ProRule annotationAdd BLAST		66
Domainⁱ	176 – 213	UBAAdd BLAST		38

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	69 – 80	Required for DNA-bindingBy similarityAdd BLAST		12
Regionⁱ	93 – 108	RNA/DNA-bindingAdd BLAST		16

Domainⁱ

The positively charged inner surface of the NAC-A/B domain is crucial for NACA localization in the nucleus and DNA-binding. This region is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit, it also displays much higher affinity for RNA than DNA.

Sequence similaritiesⁱ

Belongs to the NAC-alpha family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2239 Eukaryota COG1308 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033468
HOVERGENⁱ	HBG082004
InParanoidⁱ	Q13765
KEGG Orthology (KO) More...KOⁱ	K03626
PhylomeDBⁱ	Q13765
TreeFamⁱ	TF313348

Family and domain databases

Gene3Dⁱ	2.20.70.30, 1 hit
InterProⁱ	View protein in InterPro IPR016641 EGD2/NACA IPR038187 NAC_A/B_dom_sf IPR002715 Nas_poly-pep-assoc_cplx_dom
PANTHERⁱ	PTHR21713 PTHR21713, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01849 NAC, 1 hit
PIRSFⁱ	PIRSF015901 NAC_alpha, 1 hit
SMARTⁱ	View protein in SMART SM01407 NAC, 1 hit
PROSITEⁱ	View protein in PROSITE PS51151 NAC_AB, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q13765-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGEATETVP ATEQELPQPQ AETGSGTESD SDESVPELEE QDSTQATTQQ 
        60         70         80         90        100
AQLAAAAEID EEPVSKAKQS RSEKKARKAM SKLGLRQVTG VTRVTIRKSK 
       110        120        130        140        150
NILFVITKPD VYKSPASDTY IVFGEAKIED LSQQAQLAAA EKFKVQGEAV 
       160        170        180        190        200
SNIQENTQTP TVQEESEEEE VDETGVEVKD IELVMSQANV SRAKAVRALK 
       210 
NNSNDIVNAI MELTM

Length:215

Mass (Da):23,384

Last modified:November 1, 1996 - v1

Checksum:ⁱ05DC563A8BEF307C

GO

Isoform skNAC-2 (identifier: E9PAV3-2) [UniParc]FASTA Add to basket

Also known as: 2

The sequence of this isoform can be found in the external entry E9PAV3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:925

Mass (Da):94,681

GO

Isoform skNAC (identifier: E9PAV3-1) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry E9PAV3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:2,078

Mass (Da):205,422

GO

Sequence cautionⁱ

The sequence AAV83778 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	213	L → S in BAD96805 (Ref. 7) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY034001 mRNA Translation: AAK57544.1 AY911673 mRNA Translation: AAX14393.1 X80909 mRNA Translation: CAA56869.1 AF054187 mRNA Translation: AAC99403.1 AK090650 mRNA Translation: BAG52208.1 AK311904 mRNA Translation: BAG34845.1 CR450295 mRNA Translation: CAG29291.1 AK223085 mRNA Translation: BAD96805.1 AC117378 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96960.1 BC105120 mRNA Translation: AAI05121.1 BC105122 mRNA Translation: AAI05123.1 BC106041 mRNA Translation: AAI06042.1 AY605660 mRNA Translation: AAV83778.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31837.1 [Q13765-1]
PIRⁱ	S49326
NCBI Reference Sequences More...RefSeqⁱ	NP_001106672.1, NM_001113201.2 [Q13765-1] NP_001106673.1, NM_001113202.1 [Q13765-1] NP_001106674.2, NM_001113203.2 NP_001307122.1, NM_001320193.1 [Q13765-1] NP_001307123.1, NM_001320194.1 NP_005585.1, NM_005594.5 [Q13765-1]
UniGeneⁱ	Hs.505735

Genome annotation databases

Ensemblⁱ	ENST00000356769; ENSP00000349212; ENSG00000196531 [Q13765-1] ENST00000393891; ENSP00000377469; ENSG00000196531 [Q13765-1] ENST00000546392; ENSP00000446801; ENSG00000196531 [Q13765-1] ENST00000552540; ENSP00000447821; ENSG00000196531 [Q13765-1]
GeneIDⁱ	4666
KEGGⁱ	hsa:4666
UCSC genome browser More...UCSCⁱ	uc001sly.3 human [Q13765-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13765	Nascent polypeptide-associated complex subunit alpha		ALLMI		249	UniRef100_Q13765
HCG2016482, isoform CRA_b		HUMAN		215
Nascent polypeptide-associated complex subunit alpha isoform b		CALJA		215
NACA isoform 4		PANTR		215
nascent polypeptide-associated complex subunit alpha		TARSY		215
+36

Protein	Similar proteins		Species	Score	Length	Source
Q13765	Nascent polypeptide-associated complex subunit alpha-2		HUMAN		215	UniRef90_Q13765
Nascent polypeptide-associated complex subunit alpha		ALLMI		249
Nascent polypeptide-associated complex subunit alpha isoform b		CALJA		215
NACA isoform 4		PANTR		215
nascent polypeptide-associated complex subunit alpha		TARSY		215
+80
E9PAV3-2	NACA isoform 7		PONAB		924	UniRef90_E9PAV3-2
NACA isoform 3		PANTR		924
Uncharacterized protein		PANPA		923
UPI0007DC627E		HUMAN		940

Protein	Similar proteins		Species	Score	Length	Source
Q13765	Nascent polypeptide-associated complex subunit alpha-2		HUMAN		215	UniRef50_Q13765
Nascent polypeptide-associated complex subunit alpha		ALLMI		249
Nascent polypeptide-associated complex subunit alpha isoform b		CALJA		215
NACA isoform 4		PANTR		215
nascent polypeptide-associated complex subunit alpha		TARSY		215
+117
E9PAV3-2	NACA isoform 7		PONAB		924	UniRef50_E9PAV3-2
NACA isoform 3		PANTR		924
Uncharacterized protein		PANPA		923
Uncharacterized protein		CALJA		922
Uncharacterized protein		AOTNA		922
+19

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY034001 mRNA Translation: AAK57544.1 AY911673 mRNA Translation: AAX14393.1 X80909 mRNA Translation: CAA56869.1 AF054187 mRNA Translation: AAC99403.1 AK090650 mRNA Translation: BAG52208.1 AK311904 mRNA Translation: BAG34845.1 CR450295 mRNA Translation: CAG29291.1 AK223085 mRNA Translation: BAD96805.1 AC117378 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96960.1 BC105120 mRNA Translation: AAI05121.1 BC105122 mRNA Translation: AAI05123.1 BC106041 mRNA Translation: AAI06042.1 AY605660 mRNA Translation: AAV83778.1 Different initiation.
CCDSⁱ	CCDS31837.1 [Q13765-1]
PIRⁱ	S49326
RefSeqⁱ	NP_001106672.1, NM_001113201.2 [Q13765-1] NP_001106673.1, NM_001113202.1 [Q13765-1] NP_001106674.2, NM_001113203.2 NP_001307122.1, NM_001320193.1 [Q13765-1] NP_001307123.1, NM_001320194.1 NP_005585.1, NM_005594.5 [Q13765-1]
UniGeneⁱ	Hs.505735

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3LKX	X-ray	2.50	B	84-136	[»]
	3MCB	X-ray	1.90	A	79-132	[»]
	3MCE	X-ray	2.40	A/B/C/D	81-133	[»]
ProteinModelPortalⁱ	Q13765
SMRⁱ	Q13765
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110748, 59 interactors
DIPⁱ	DIP-43878N
IntActⁱ	Q13765, 31 interactors
MINTⁱ	Q13765

Protein family/group databases

Allergomeⁱ	3323 Hom s 2.0101 412 Hom s 2

Allergomeⁱ

3323 Hom s 2.0101
412 Hom s 2

PTM databases

iPTMnetⁱ	Q13765
SwissPalmⁱ	Q13765

Polymorphism and mutation databases

BioMutaⁱ	NACA
DMDMⁱ	71151996

Proteomic databases

EPDⁱ	Q13765
MaxQBⁱ	Q13765
PeptideAtlasⁱ	Q13765
PRIDEⁱ	Q13765
ProteomicsDBⁱ	59679
TopDownProteomicsⁱ	Q13765-1 [Q13765-1]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000356769; ENSP00000349212; ENSG00000196531 [Q13765-1] ENST00000393891; ENSP00000377469; ENSG00000196531 [Q13765-1] ENST00000546392; ENSP00000446801; ENSG00000196531 [Q13765-1] ENST00000552540; ENSP00000447821; ENSG00000196531 [Q13765-1]
GeneIDⁱ	4666
KEGGⁱ	hsa:4666
UCSCⁱ	uc001sly.3 human [Q13765-1]

Organism-specific databases

CTDⁱ	4666
DisGeNETⁱ	4666
EuPathDBⁱ	HostDB:ENSG00000196531.10
GeneCardsⁱ	NACA
H-InvDBⁱ	HIX0034277
HGNCⁱ	HGNC:7629 NACA
HPAⁱ	HPA073152 HPA073648
MIMⁱ	601234 gene
neXtProtⁱ	NX_Q13765
OpenTargetsⁱ	ENSG00000196531
PharmGKBⁱ	PA31433
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2239 Eukaryota COG1308 LUCA
GeneTreeⁱ	ENSGT00440000033468
HOVERGENⁱ	HBG082004
InParanoidⁱ	Q13765
KOⁱ	K03626
PhylomeDBⁱ	Q13765
TreeFamⁱ	TF313348

Enzyme and pathway databases

SIGNORⁱ	Q13765

SIGNORⁱ

Q13765

Miscellaneous databases

ChiTaRSⁱ	NACA human
EvolutionaryTraceⁱ	Q13765
GeneWikiⁱ	NACA_(gene)
GenomeRNAiⁱ	4666
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196531 Expressed in 241 organ(s), highest expression level in testis
CleanExⁱ	HS_NACA
ExpressionAtlasⁱ	Q13765 baseline and differential
Genevisibleⁱ	Q13765 HS

Family and domain databases

Gene3Dⁱ	2.20.70.30, 1 hit
InterProⁱ	View protein in InterPro IPR016641 EGD2/NACA IPR038187 NAC_A/B_dom_sf IPR002715 Nas_poly-pep-assoc_cplx_dom
PANTHERⁱ	PTHR21713 PTHR21713, 1 hit
Pfamⁱ	View protein in Pfam PF01849 NAC, 1 hit
PIRSFⁱ	PIRSF015901 NAC_alpha, 1 hit
SMARTⁱ	View protein in SMART SM01407 NAC, 1 hit
PROSITEⁱ	View protein in PROSITE PS51151 NAC_AB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NACA_HUMAN
Accessionⁱ	Q13765Primary (citable) accession number: Q13765 Secondary accession number(s): A8MTN7 , B2R4P8, F8VU71, Q3KQV4, Q53A18, Q53G46
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Allergens
Nomenclature of allergens and list of entries

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UniProtKB - Q13765 (NACA_HUMAN)

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Nascent polypeptide-associated complex subunit alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Protein family/group databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ