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UniProtKB - Q13761 (RUNX3_HUMAN)

Entry version 213 (23 Feb 2022)
Sequence version 2 (01 Nov 1999)
Previous versions | rss
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Protein

Runt-related transcription factor 3

Gene

RUNX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity).

May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712).

CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13761

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-4411364, Binding of TCF/LEF:CTNNB1 to target gene promoters
R-HSA-8941855, RUNX3 regulates CDKN1A transcription
R-HSA-8941856, RUNX3 regulates NOTCH signaling
R-HSA-8941858, Regulation of RUNX3 expression and activity
R-HSA-8949275, RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8951430, RUNX3 regulates WNT signaling
R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription
R-HSA-8951911, RUNX3 regulates RUNX1-mediated transcription
R-HSA-8951936, RUNX3 regulates p14-ARF
R-HSA-8952158, RUNX3 regulates BCL2L11 (BIM) transcription

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13761

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13761

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Runt-related transcription factor 3
Alternative name(s):
Acute myeloid leukemia 2 protein
Core-binding factor subunit alpha-3
Short name:
CBF-alpha-3
Oncogene AML-2
Polyomavirus enhancer-binding protein 2 alpha C subunit
Short name:
PEA2-alpha C
Short name:
PEBP2-alpha C
SL3-3 enhancer factor 1 alpha C subunit
SL3/AKV core-binding factor alpha C subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RUNX3
Synonyms:AML2, CBFA3, PEBP2A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10473, RUNX3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600210, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13761

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000020633

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		864

Open Targets

More...OpenTargetsi		ENSG00000020633

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34886

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13761, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RUNX3

Domain mapping of disease mutations (DMDM)

More...DMDMi		17368453

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001746621 – 415Runt-related transcription factor 3Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki192Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei243PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13761

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13761

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13761

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13761

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13761

PeptideAtlas

More...PeptideAtlasi		Q13761

PRoteomics IDEntifications database

More...PRIDEi		Q13761

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59677 [Q13761-1]
59678 [Q13761-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q13761, 11 sites, 1 O-linked glycan (11 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13761

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13761

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q13761

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in gastric cancer tissues (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000020633, Expressed in granulocyte and 183 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13761, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13761, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000020633, Tissue enhanced (bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with CBFB. RUNX3 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization (By similarity).

Interacts with TLE1 and SUV39H1 (PubMed:9751710 and PubMed:16652147). The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain)(PubMed:20100835).

Interacts with FYN and LCK (PubMed:20100835).

Interacts with FOXP3 (PubMed:17377532).

Interacts with ZFHX3 (PubMed:20599712).

Interacts with TBX21 (By similarity).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107312, 55 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q13761

Protein interaction database and analysis system

More...IntActi		Q13761, 18 interactors

Molecular INTeraction database

More...MINTi		Q13761

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000382800

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13761, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13761

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 182RuntPROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 48DisorderedSequence analysisAdd BLAST48
Regioni176 – 266DisorderedSequence analysisAdd BLAST91
Regioni375 – 415DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi176 – 204Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi211 – 244Polar residuesSequence analysisAdd BLAST34
Compositional biasi389 – 403Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3982, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156598

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032910_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13761

Identification of Orthologs from Complete Genome Data

More...OMAi		TQGLWPE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13761

TreeFam database of animal gene trees

More...TreeFami		TF321496

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.720, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000040, AML1_Runt
IPR008967, p53-like_TF_DNA-bd
IPR012346, p53/RUNT-type_TF_DNA-bd_sf
IPR013524, Runt_dom
IPR013711, RunxI_C_dom
IPR016554, TF_Runt-rel_RUNX

The PANTHER Classification System

More...PANTHERi		PTHR11950, PTHR11950, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00853, Runt, 1 hit
PF08504, RunxI, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF009374, TF_Runt-rel_RUNX, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00967, ONCOGENEAML1

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49417, SSF49417, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51062, RUNT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13761-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRIPVDPSTS RRFTPPSPAF PCGGGGGKMG ENSGALSAQA AVGPGGRARP 
        60         70         80         90        100
EVRSMVDVLA DHAGELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGD 
       110        120        130        140        150
VPDGTVVTVM AGNDENYSAE LRNASAVMKN QVARFNDLRF VGRSGRGKSF 
       160        170        180        190        200
TLTITVFTNP TQVATYHRAI KVTVDGPREP RRHRQKLEDQ TKPFPDRFGD 
       210        220        230        240        250
LERLRMRVTP STPSPRGSLS TTSHFSSQPQ TPIQGTSELN PFSDPRQFDR 
       260        270        280        290        300
SFPTLPTLTE SRFPDPRMHY PGAMSAAFPY SATPSGTSIS SLSVAGMPAT 
       310        320        330        340        350
SRFHHTYLPP PYPGAPQNQS GPFQANPSPY HLYYGTSSGS YQFSMVAGSS 
       360        370        380        390        400
SGGDRSPTRM LASCTSSAAS VAAGNLMNPS LGGQSDGVEA DGSHSNSPTA 
       410 
LSTPGRMDEA VWRPY
Length:415
Mass (Da):44,356
Last modified:November 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i593FBFB3C4639BBD
GO
Isoform 2 (identifier: Q13761-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MRIPV → MASNSIFDSFPTYSPTFIR

Show »
Length:429
Mass (Da):45,922
Checksum:iE9A43E96EDF82389
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti249D → V in CAA56093 (PubMed:7835892).Curated1
Sequence conflicti253P → S in CAA56093 (PubMed:7835892).Curated1
Sequence conflicti256P → S in CAA56093 (PubMed:7835892).Curated1
Sequence conflicti259T → S in CAA56093 (PubMed:7835892).Curated1
Sequence conflicti268 – 269MH → IY in CAA56093 (PubMed:7835892).Curated2
Sequence conflicti271P → T in CAA56093 (PubMed:7835892).Curated1
Sequence conflicti297 – 298MP → IS in CAA56093 (PubMed:7835892).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0059491 – 5MRIPV → MASNSIFDSFPTYSPTFIR in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z35278 mRNA Translation: CAA84541.1
X79550 mRNA Translation: CAA56093.2
AL023096 Genomic DNA No translation available.
AL445471 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95148.1
BC013362 mRNA Translation: AAH13362.1
U14520 Genomic DNA Translation: AAA86465.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS257.1 [Q13761-1]
CCDS30633.1 [Q13761-2]

Protein sequence database of the Protein Information Resource

More...PIRi		B55563
S60078

NCBI Reference Sequences

More...RefSeqi		NP_001026850.1, NM_001031680.2 [Q13761-2]
NP_001307601.1, NM_001320672.1 [Q13761-2]
NP_004341.1, NM_004350.2 [Q13761-1]
XP_005246081.1, XM_005246024.4 [Q13761-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000308873; ENSP00000308051; ENSG00000020633
ENST00000338888; ENSP00000343477; ENSG00000020633 [Q13761-2]
ENST00000399916; ENSP00000382800; ENSG00000020633 [Q13761-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		864

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:864

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000308873.11; ENSP00000308051.6; NM_004350.3; NP_004341.1

UCSC genome browser

More...UCSCi		uc001bjq.4, human [Q13761-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35278 mRNA Translation: CAA84541.1
X79550 mRNA Translation: CAA56093.2
AL023096 Genomic DNA No translation available.
AL445471 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95148.1
BC013362 mRNA Translation: AAH13362.1
U14520 Genomic DNA Translation: AAA86465.1
CCDSiCCDS257.1 [Q13761-1]
CCDS30633.1 [Q13761-2]
PIRiB55563
S60078
RefSeqiNP_001026850.1, NM_001031680.2 [Q13761-2]
NP_001307601.1, NM_001320672.1 [Q13761-2]
NP_004341.1, NM_004350.2 [Q13761-1]
XP_005246081.1, XM_005246024.4 [Q13761-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W69X-ray2.80I/J/K/L133-141[»]
SMRiQ13761
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107312, 55 interactors
ELMiQ13761
IntActiQ13761, 18 interactors
MINTiQ13761
STRINGi9606.ENSP00000382800

PTM databases

GlyGeniQ13761, 11 sites, 1 O-linked glycan (11 sites)
iPTMnetiQ13761
PhosphoSitePlusiQ13761
SwissPalmiQ13761

Genetic variation databases

BioMutaiRUNX3
DMDMi17368453

Proteomic databases

EPDiQ13761
jPOSTiQ13761
MassIVEiQ13761
MaxQBiQ13761
PaxDbiQ13761
PeptideAtlasiQ13761
PRIDEiQ13761
ProteomicsDBi59677 [Q13761-1]
59678 [Q13761-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1124, 690 antibodies from 43 providers

The DNASU plasmid repository

More...DNASUi		864

Genome annotation databases

EnsembliENST00000308873; ENSP00000308051; ENSG00000020633
ENST00000338888; ENSP00000343477; ENSG00000020633 [Q13761-2]
ENST00000399916; ENSP00000382800; ENSG00000020633 [Q13761-2]
GeneIDi864
KEGGihsa:864
MANE-SelectiENST00000308873.11; ENSP00000308051.6; NM_004350.3; NP_004341.1
UCSCiuc001bjq.4, human [Q13761-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		864
DisGeNETi864

GeneCards: human genes, protein and diseases

More...GeneCardsi		RUNX3
HGNCiHGNC:10473, RUNX3
HPAiENSG00000020633, Tissue enhanced (bone marrow, lymphoid tissue)
MIMi600210, gene
neXtProtiNX_Q13761
OpenTargetsiENSG00000020633
PharmGKBiPA34886
VEuPathDBiHostDB:ENSG00000020633

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3982, Eukaryota
GeneTreeiENSGT00940000156598
HOGENOMiCLU_032910_3_0_1
InParanoidiQ13761
OMAiTQGLWPE
PhylomeDBiQ13761
TreeFamiTF321496

Enzyme and pathway databases

PathwayCommonsiQ13761
ReactomeiR-HSA-4411364, Binding of TCF/LEF:CTNNB1 to target gene promoters
R-HSA-8941855, RUNX3 regulates CDKN1A transcription
R-HSA-8941856, RUNX3 regulates NOTCH signaling
R-HSA-8941858, Regulation of RUNX3 expression and activity
R-HSA-8949275, RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8951430, RUNX3 regulates WNT signaling
R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription
R-HSA-8951911, RUNX3 regulates RUNX1-mediated transcription
R-HSA-8951936, RUNX3 regulates p14-ARF
R-HSA-8952158, RUNX3 regulates BCL2L11 (BIM) transcription
SignaLinkiQ13761
SIGNORiQ13761

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		864, 6 hits in 1057 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RUNX3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RUNX3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		864
PharosiQ13761, Tbio

Protein Ontology

More...PROi		PR:Q13761
RNActiQ13761, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000020633, Expressed in granulocyte and 183 other tissues
ExpressionAtlasiQ13761, baseline and differential
GenevisibleiQ13761, HS

Family and domain databases

Gene3Di2.60.40.720, 1 hit
InterProiView protein in InterPro
IPR000040, AML1_Runt
IPR008967, p53-like_TF_DNA-bd
IPR012346, p53/RUNT-type_TF_DNA-bd_sf
IPR013524, Runt_dom
IPR013711, RunxI_C_dom
IPR016554, TF_Runt-rel_RUNX
PANTHERiPTHR11950, PTHR11950, 1 hit
PfamiView protein in Pfam
PF00853, Runt, 1 hit
PF08504, RunxI, 1 hit
PIRSFiPIRSF009374, TF_Runt-rel_RUNX, 1 hit
PRINTSiPR00967, ONCOGENEAML1
SUPFAMiSSF49417, SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS51062, RUNT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRUNX3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13761
Secondary accession number(s): B1AJV5, Q12969, Q13760
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1999
Last modified: February 23, 2022
This is version 213 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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