RUNX3

Functionⁱ

Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

ATP binding
Source: UniProtKB
Non-traceable author statementⁱ
- 7835892
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 7607690
DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
RNA polymerase II regulatory region sequence-specific DNA binding Source: BHF-UCL

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chondrocyte differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
hemopoiesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of CD4-positive, alpha-beta T cell differentiation Source: UniProtKB
negative regulation of cell cycle Source: UniProtKB
negative regulation of epithelial cell proliferation Source: UniProtKB
negative regulation of transcription by RNA polymerase II Source: BHF-UCL
neuron differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peripheral nervous system neuron development
Source: BHF-UCL
Traceable author statementⁱ
- 20096094
positive regulation of CD8-positive, alpha-beta T cell differentiation Source: UniProtKB
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 20599712
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 20100835
regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 7622058
response to transforming growth factor beta
Source: UniProtKB
Inferred from direct assayⁱ
- 20599712
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 7607690

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-8941855 RUNX3 regulates CDKN1A transcription R-HSA-8941856 RUNX3 regulates NOTCH signaling R-HSA-8941858 Regulation of RUNX3 expression and activity R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration R-HSA-8951430 RUNX3 regulates WNT signaling R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription R-HSA-8951936 RUNX3 regulates p14-ARF R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription
SIGNORⁱ	Q13761

Reactomeⁱ

R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters
R-HSA-8941855 RUNX3 regulates CDKN1A transcription
R-HSA-8941856 RUNX3 regulates NOTCH signaling
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8951430 RUNX3 regulates WNT signaling
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription
R-HSA-8951936 RUNX3 regulates p14-ARF
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription

SIGNORⁱ

Q13761

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Runt-related transcription factor 3 Alternative name(s): Acute myeloid leukemia 2 protein Core-binding factor subunit alpha-3 Short name: CBF-alpha-3 Oncogene AML-2 Polyomavirus enhancer-binding protein 2 alpha C subunit Short name: PEA2-alpha C Short name: PEBP2-alpha C SL3-3 enhancer factor 1 alpha C subunit SL3/AKV core-binding factor alpha C subunit
Gene namesⁱ	Name:RUNX3 Synonyms:AML2, CBFA3, PEBP2A3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000020633.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10473 RUNX3
MIMⁱ	600210 gene
neXtProtⁱ	NX_Q13761

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	864
Open Targets More...OpenTargetsⁱ	ENSG00000020633
PharmGKBⁱ	PA34886

Polymorphism and mutation databases

BioMutaⁱ	RUNX3
DMDMⁱ	17368453

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000174662	1 – 415	Runt-related transcription factor 3Add BLAST		415

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	192	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	243	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q13761
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13761
PaxDbⁱ	Q13761
PeptideAtlas More...PeptideAtlasⁱ	Q13761
PRIDEⁱ	Q13761
ProteomicsDBⁱ	59677 59678 [Q13761-2]

PTM databases

iPTMnetⁱ	Q13761
PhosphoSitePlusⁱ	Q13761
SwissPalmⁱ	Q13761

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000020633 Expressed in 161 organ(s), highest expression level in tonsil
CleanExⁱ	HS_RUNX3
ExpressionAtlasⁱ	Q13761 baseline and differential
Genevisibleⁱ	Q13761 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025416 HPA004195 HPA059006

HPAⁱ

CAB025416
HPA004195
HPA059006

Interactionⁱ

Subunit structureⁱ

Heterodimer with CBFB. RUNX3 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization (By similarity). Interacts with TLE1 and SUV39H1 (PubMed:9751710 and PubMed:16652147). The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain)(PubMed:20100835). Interacts with FYN and LCK (PubMed:20100835). Interacts with FOXP3 (PubMed:17377532). Interacts with ZFHX3 (PubMed:20599712). Interacts with TBX21 (By similarity).By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BRD2	P25440	8	EBI-925990,EBI-2874802
CTNNB1	P35222	12	EBI-925990,EBI-491549
EP300	Q09472	7	EBI-925990,EBI-447295
HDAC4	P56524	9	EBI-925990,EBI-308629
HDAC5	Q9UQL6	5	EBI-925990,EBI-715576
TCF7L2	Q9NQB0	14	EBI-925990,EBI-924724
TLE1	Q04724	3	EBI-925990,EBI-711424

Protein-protein interaction databases

BioGridⁱ	107312, 31 interactors
ELMⁱ	Q13761
IntActⁱ	Q13761, 17 interactors
Molecular INTeraction database More...MINTⁱ	Q13761
STRINGⁱ	9606.ENSP00000343477

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13761
SMRⁱ	Q13761
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	54 – 182	RuntPROSITE-ProRule annotationAdd BLAST		129

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	23 – 27	Poly-Gly		5
Compositional biasⁱ	191 – 415	Pro/Ser/Thr-richAdd BLAST		225

Domainⁱ

A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.

Phylogenomic databases

eggNOGⁱ	KOG3982 Eukaryota ENOG4111J4Y LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016964
HOGENOMⁱ	HOG000045616
HOVERGENⁱ	HBG060268
InParanoidⁱ	Q13761
KEGG Orthology (KO) More...KOⁱ	K09279
OMAⁱ	TRFHHTY
PhylomeDBⁱ	Q13761
TreeFamⁱ	TF321496

Family and domain databases

Gene3Dⁱ	2.60.40.720, 1 hit
InterProⁱ	View protein in InterPro IPR000040 AML1_Runt IPR008967 p53-like_TF_DNA-bd IPR012346 p53/RUNT-type_TF_DNA-bd_sf IPR013524 Runt_dom IPR013711 RunxI_C_dom IPR016554 TF_Runt-rel_RUNX
PANTHERⁱ	PTHR11950 PTHR11950, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00853 Runt, 1 hit PF08504 RunxI, 1 hit
PIRSFⁱ	PIRSF009374 TF_Runt-rel_RUNX, 1 hit
PRINTSⁱ	PR00967 ONCOGENEAML1
SUPFAMⁱ	SSF49417 SSF49417, 1 hit
PROSITEⁱ	View protein in PROSITE PS51062 RUNT, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q13761-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRIPVDPSTS RRFTPPSPAF PCGGGGGKMG ENSGALSAQA AVGPGGRARP 
        60         70         80         90        100
EVRSMVDVLA DHAGELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGD 
       110        120        130        140        150
VPDGTVVTVM AGNDENYSAE LRNASAVMKN QVARFNDLRF VGRSGRGKSF 
       160        170        180        190        200
TLTITVFTNP TQVATYHRAI KVTVDGPREP RRHRQKLEDQ TKPFPDRFGD 
       210        220        230        240        250
LERLRMRVTP STPSPRGSLS TTSHFSSQPQ TPIQGTSELN PFSDPRQFDR 
       260        270        280        290        300
SFPTLPTLTE SRFPDPRMHY PGAMSAAFPY SATPSGTSIS SLSVAGMPAT 
       310        320        330        340        350
SRFHHTYLPP PYPGAPQNQS GPFQANPSPY HLYYGTSSGS YQFSMVAGSS 
       360        370        380        390        400
SGGDRSPTRM LASCTSSAAS VAAGNLMNPS LGGQSDGVEA DGSHSNSPTA 
       410 
LSTPGRMDEA VWRPY

Length:415

Mass (Da):44,356

Last modified:November 1, 1999 - v2

Checksum:ⁱ593FBFB3C4639BBD

GO

Isoform 2 (identifier: Q13761-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-5: MRIPV → MASNSIFDSFPTYSPTFIR

« Hide

        10         20         30         40         50
MASNSIFDSF PTYSPTFIRD PSTSRRFTPP SPAFPCGGGG GKMGENSGAL 
        60         70         80         90        100
SAQAAVGPGG RARPEVRSMV DVLADHAGEL VRTDSPNFLC SVLPSHWRCN 
       110        120        130        140        150
KTLPVAFKVV ALGDVPDGTV VTVMAGNDEN YSAELRNASA VMKNQVARFN 
       160        170        180        190        200
DLRFVGRSGR GKSFTLTITV FTNPTQVATY HRAIKVTVDG PREPRRHRQK 
       210        220        230        240        250
LEDQTKPFPD RFGDLERLRM RVTPSTPSPR GSLSTTSHFS SQPQTPIQGT 
       260        270        280        290        300
SELNPFSDPR QFDRSFPTLP TLTESRFPDP RMHYPGAMSA AFPYSATPSG 
       310        320        330        340        350
TSISSLSVAG MPATSRFHHT YLPPPYPGAP QNQSGPFQAN PSPYHLYYGT 
       360        370        380        390        400
SSGSYQFSMV AGSSSGGDRS PTRMLASCTS SAASVAAGNL MNPSLGGQSD 
       410        420 
GVEADGSHSN SPTALSTPGR MDEAVWRPY

Show »

Length:429

Mass (Da):45,922

Checksum:ⁱE9A43E96EDF82389

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	249	D → V in CAA56093 (PubMed:7835892).Curated	1
Sequence conflictⁱ	253	P → S in CAA56093 (PubMed:7835892).Curated	1
Sequence conflictⁱ	256	P → S in CAA56093 (PubMed:7835892).Curated	1
Sequence conflictⁱ	259	T → S in CAA56093 (PubMed:7835892).Curated	1
Sequence conflictⁱ	268 – 269	MH → IY in CAA56093 (PubMed:7835892).Curated	2
Sequence conflictⁱ	271	P → T in CAA56093 (PubMed:7835892).Curated	1
Sequence conflictⁱ	297 – 298	MP → IS in CAA56093 (PubMed:7835892).Curated	2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005949	1 – 5	MRIPV → MASNSIFDSFPTYSPTFIR in isoform 2. 1 Publication		5

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z35278 mRNA Translation: CAA84541.1 X79550 mRNA Translation: CAA56093.2 AL023096 Genomic DNA No translation available. AL445471 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW95148.1 BC013362 mRNA Translation: AAH13362.1 U14520 Genomic DNA Translation: AAA86465.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS257.1 [Q13761-1] CCDS30633.1 [Q13761-2]
PIRⁱ	B55563 S60078
NCBI Reference Sequences More...RefSeqⁱ	NP_001026850.1, NM_001031680.2 [Q13761-2] NP_001307601.1, NM_001320672.1 [Q13761-2] NP_004341.1, NM_004350.2 [Q13761-1] XP_005246081.1, XM_005246024.4 [Q13761-2]
UniGeneⁱ	Hs.170019

Genome annotation databases

Ensemblⁱ	ENST00000308873; ENSP00000308051; ENSG00000020633 [Q13761-1] ENST00000338888; ENSP00000343477; ENSG00000020633 [Q13761-2] ENST00000399916; ENSP00000382800; ENSG00000020633 [Q13761-2]
GeneIDⁱ	864
KEGGⁱ	hsa:864
UCSC genome browser More...UCSCⁱ	uc001bjq.4 human [Q13761-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13761	Runt-related transcription factor 3		MOUSE		409	UniRef90_Q64131
Runt-related transcription factor		Enhydra lutris kenyoni		433
Runt-related transcription factor		LIPVE		433
Runt-related transcription factor		PROCO		433
Runt-related transcription factor		Yangtze finless porpoise		433
+108

Protein	Similar proteins		Species	Score	Length	Source
Q13761	Isoform 2 of Runt-related transcription factor 1		MOUSE		387	UniRef50_Q03347-2
Runt-related transcription factor		Enhydra lutris kenyoni		416
Runt-related transcription factor		DELLE		416
Runt-related transcription factor		Yangtze finless porpoise		416
Runt-related transcription factor		PIG		416
+411

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z35278 mRNA Translation: CAA84541.1 X79550 mRNA Translation: CAA56093.2 AL023096 Genomic DNA No translation available. AL445471 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW95148.1 BC013362 mRNA Translation: AAH13362.1 U14520 Genomic DNA Translation: AAA86465.1
CCDSⁱ	CCDS257.1 [Q13761-1] CCDS30633.1 [Q13761-2]
PIRⁱ	B55563 S60078
RefSeqⁱ	NP_001026850.1, NM_001031680.2 [Q13761-2] NP_001307601.1, NM_001320672.1 [Q13761-2] NP_004341.1, NM_004350.2 [Q13761-1] XP_005246081.1, XM_005246024.4 [Q13761-2]
UniGeneⁱ	Hs.170019

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5W69	X-ray	2.80	I/J/K/L	133-141	[»]
ProteinModelPortalⁱ	Q13761
SMRⁱ	Q13761
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107312, 31 interactors
ELMⁱ	Q13761
IntActⁱ	Q13761, 17 interactors
MINTⁱ	Q13761
STRINGⁱ	9606.ENSP00000343477

PTM databases

iPTMnetⁱ	Q13761
PhosphoSitePlusⁱ	Q13761
SwissPalmⁱ	Q13761

Polymorphism and mutation databases

BioMutaⁱ	RUNX3
DMDMⁱ	17368453

Proteomic databases

EPDⁱ	Q13761
MaxQBⁱ	Q13761
PaxDbⁱ	Q13761
PeptideAtlasⁱ	Q13761
PRIDEⁱ	Q13761
ProteomicsDBⁱ	59677 59678 [Q13761-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000308873; ENSP00000308051; ENSG00000020633 [Q13761-1] ENST00000338888; ENSP00000343477; ENSG00000020633 [Q13761-2] ENST00000399916; ENSP00000382800; ENSG00000020633 [Q13761-2]
GeneIDⁱ	864
KEGGⁱ	hsa:864
UCSCⁱ	uc001bjq.4 human [Q13761-1]

Organism-specific databases

CTDⁱ	864
DisGeNETⁱ	864
EuPathDBⁱ	HostDB:ENSG00000020633.18
GeneCardsⁱ	RUNX3
HGNCⁱ	HGNC:10473 RUNX3
HPAⁱ	CAB025416 HPA004195 HPA059006
MIMⁱ	600210 gene
neXtProtⁱ	NX_Q13761
OpenTargetsⁱ	ENSG00000020633
PharmGKBⁱ	PA34886
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3982 Eukaryota ENOG4111J4Y LUCA
GeneTreeⁱ	ENSGT00390000016964
HOGENOMⁱ	HOG000045616
HOVERGENⁱ	HBG060268
InParanoidⁱ	Q13761
KOⁱ	K09279
OMAⁱ	TRFHHTY
PhylomeDBⁱ	Q13761
TreeFamⁱ	TF321496

Enzyme and pathway databases

Reactomeⁱ	R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-8941855 RUNX3 regulates CDKN1A transcription R-HSA-8941856 RUNX3 regulates NOTCH signaling R-HSA-8941858 Regulation of RUNX3 expression and activity R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration R-HSA-8951430 RUNX3 regulates WNT signaling R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription R-HSA-8951936 RUNX3 regulates p14-ARF R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription
SIGNORⁱ	Q13761

Reactomeⁱ

R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters
R-HSA-8941855 RUNX3 regulates CDKN1A transcription
R-HSA-8941856 RUNX3 regulates NOTCH signaling
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8951430 RUNX3 regulates WNT signaling
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription
R-HSA-8951936 RUNX3 regulates p14-ARF
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription

SIGNORⁱ

Q13761

Miscellaneous databases

ChiTaRSⁱ	RUNX3 human
GeneWikiⁱ	RUNX3
GenomeRNAiⁱ	864
Protein Ontology More...PROⁱ	PR:Q13761
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000020633 Expressed in 161 organ(s), highest expression level in tonsil
CleanExⁱ	HS_RUNX3
ExpressionAtlasⁱ	Q13761 baseline and differential
Genevisibleⁱ	Q13761 HS

Family and domain databases

Gene3Dⁱ	2.60.40.720, 1 hit
InterProⁱ	View protein in InterPro IPR000040 AML1_Runt IPR008967 p53-like_TF_DNA-bd IPR012346 p53/RUNT-type_TF_DNA-bd_sf IPR013524 Runt_dom IPR013711 RunxI_C_dom IPR016554 TF_Runt-rel_RUNX
PANTHERⁱ	PTHR11950 PTHR11950, 1 hit
Pfamⁱ	View protein in Pfam PF00853 Runt, 1 hit PF08504 RunxI, 1 hit
PIRSFⁱ	PIRSF009374 TF_Runt-rel_RUNX, 1 hit
PRINTSⁱ	PR00967 ONCOGENEAML1
SUPFAMⁱ	SSF49417 SSF49417, 1 hit
PROSITEⁱ	View protein in PROSITE PS51062 RUNT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RUNX3_HUMAN
Accessionⁱ	Q13761Primary (citable) accession number: Q13761 Secondary accession number(s): B1AJV5, Q12969, Q13760
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 192 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q13761 (RUNX3_HUMAN)

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Runt-related transcription factor 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ