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UniProtKB - Q13753 (LAMC2_HUMAN)

Entry version 202 (07 Oct 2020)
Sequence version 2 (07 Mar 2006)
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Protein

Laminin subunit gamma-2

Gene

LAMC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.1 Publication

Miscellaneous

Binds heparin.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13753

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228, Degradation of the extracellular matrix
R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures
R-HSA-2214320, Anchoring fibril formation
R-HSA-3000157, Laminin interactions
R-HSA-3000171, Non-integrin membrane-ECM interactions
R-HSA-446107, Type I hemidesmosome assembly
R-HSA-8874081, MET activates PTK2 signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13753

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit gamma-2
Alternative name(s):
Cell-scattering factor 140 kDa subunit
Short name:
CSF 140 kDa subunit
Epiligrin subunit gamma
Kalinin subunit gamma
Kalinin/nicein/epiligrin 100 kDa subunit
Ladsin 140 kDa subunit
Laminin B2t chain
Laminin-5 subunit gamma
Large adhesive scatter factor 140 kDa subunit
Nicein subunit gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMC2
Synonyms:LAMB2T, LAMNB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000058085.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:6493, LAMC2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		150292, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13753

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epidermolysis bullosa, junctional, Herlitz type (H-JEB)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infantile and lethal form of junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement In the Herlitz type, death occurs usually within the first six months of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic.
Related information in OMIM

Keywords - Diseasei

Epidermolysis bullosa

Organism-specific databases

DisGeNET

More...DisGeNETi		3918

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		LAMC2

MalaCards human disease database

More...MalaCardsi		LAMC2
MIMi226700, phenotype

Open Targets

More...OpenTargetsi		ENSG00000058085

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		79405, Junctional epidermolysis bullosa inversa
79402, Junctional epidermolysis bullosa, generalized intermediate
79404, Junctional epidermolysis bullosa, generalized severe

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30281

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13753, Tbio

Protein family/group databases

Allergome; a platform for allergen knowledge

More...Allergomei		8331, Hom s Laminin gamma_2

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2364187

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LAMC2

Domain mapping of disease mutations (DMDM)

More...DMDMi		90185107

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001707722 – 1193Laminin subunit gamma-2Add BLAST1172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 37PROSITE-ProRule annotation
Disulfide bondi30 ↔ 53PROSITE-ProRule annotation
Disulfide bondi56 ↔ 65PROSITE-ProRule annotation
Disulfide bondi68 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 96PROSITE-ProRule annotation
Disulfide bondi86 ↔ 102PROSITE-ProRule annotation
Disulfide bondi104 ↔ 113PROSITE-ProRule annotation
Disulfide bondi116 ↔ 128PROSITE-ProRule annotation
Disulfide bondi139 ↔ 150PROSITE-ProRule annotation
Disulfide bondi141 ↔ 155PROSITE-ProRule annotation
Disulfide bondi157 ↔ 166PROSITE-ProRule annotation
Disulfide bondi169 ↔ 184PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi462 ↔ 470PROSITE-ProRule annotation
Disulfide bondi464 ↔ 481PROSITE-ProRule annotation
Disulfide bondi484 ↔ 493PROSITE-ProRule annotation
Disulfide bondi496 ↔ 514PROSITE-ProRule annotation
Disulfide bondi517 ↔ 531PROSITE-ProRule annotation
Disulfide bondi519 ↔ 538PROSITE-ProRule annotation
Disulfide bondi541 ↔ 550PROSITE-ProRule annotation
Disulfide bondi553 ↔ 570PROSITE-ProRule annotation
Disulfide bondi573 ↔ 585PROSITE-ProRule annotation
Disulfide bondi575 ↔ 591PROSITE-ProRule annotation
Disulfide bondi593 ↔ 602PROSITE-ProRule annotation
Disulfide bondi609InterchainCurated
Disulfide bondi612InterchainCurated
Glycosylationi942N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1033N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1184InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13753

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13753

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13753

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13753

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13753

PeptideAtlas

More...PeptideAtlasi		Q13753

PRoteomics IDEntifications database

More...PRIDEi		Q13753

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59675 [Q13753-1]
59676 [Q13753-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1445, 2 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q13753, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13753

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q13753

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13753

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000058085, Expressed in islet of Langerhans and 178 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13753, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000058085, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-2 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein).

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110112, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1774, Laminin-332 complex variant A
CPX-1783, Laminin-522 complex
CPX-3165, Laminin-332 complex variant B

Protein interaction database and analysis system

More...IntActi		Q13753, 2 interactors

Molecular INTeraction database

More...MINTi		Q13753

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264144

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13753, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13753

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 83Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini84 – 130Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST47
Domaini139 – 186Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST48
Domaini187 – 196Laminin EGF-like 4; first partPROSITE-ProRule annotation10
Domaini213 – 381Laminin IV type APROSITE-ProRule annotationAdd BLAST169
Domaini382 – 415Laminin EGF-like 4; second partPROSITE-ProRule annotationAdd BLAST34
Domaini416 – 461Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST46
Domaini462 – 516Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST55
Domaini517 – 572Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST56
Domaini573 – 602Laminin EGF-like 8; truncatedPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni603 – 1193Domain II and IAdd BLAST591

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili611 – 718Sequence analysisAdd BLAST108
Coiled coili811 – 1076Sequence analysisAdd BLAST266
Coiled coili1117 – 1193Sequence analysisAdd BLAST77

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain IV is globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1836, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160470

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002471_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13753

KEGG Orthology (KO)

More...KOi		K06246

Identification of Orthologs from Complete Genome Data

More...OMAi		GECYSGD

Database of Orthologous Groups

More...OrthoDBi		156553at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13753

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR000034, Laminin_IV

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 6 hits
SM00180, EGF_Lam, 7 hits
SM00281, LamB, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 6 hits
PS50027, EGF_LAM_2, 6 hits
PS51115, LAMININ_IVA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: Q13753-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPALWLGCCL CFSLLLPAAR ATSRREVCDC NGKSRQCIFD RELHRQTGNG 
        60         70         80         90        100
FRCLNCNDNT DGIHCEKCKN GFYRHRERDR CLPCNCNSKG SLSARCDNSG 
       110        120        130        140        150
RCSCKPGVTG ARCDRCLPGF HMLTDAGCTQ DQRLLDSKCD CDPAGIAGPC 
       160        170        180        190        200
DAGRCVCKPA VTGERCDRCR SGYYNLDGGN PEGCTQCFCY GHSASCRSSA 
       210        220        230        240        250
EYSVHKITST FHQDVDGWKA VQRNGSPAKL QWSQRHQDVF SSAQRLDPVY 
       260        270        280        290        300
FVAPAKFLGN QQVSYGQSLS FDYRVDRGGR HPSAHDVILE GAGLRITAPL 
       310        320        330        340        350
MPLGKTLPCG LTKTYTFRLN EHPSNNWSPQ LSYFEYRRLL RNLTALRIRA 
       360        370        380        390        400
TYGEYSTGYI DNVTLISARP VSGAPAPWVE QCICPVGYKG QFCQDCASGY 
       410        420        430        440        450
KRDSARLGPF GTCIPCNCQG GGACDPDTGD CYSGDENPDI ECADCPIGFY 
       460        470        480        490        500
NDPHDPRSCK PCPCHNGFSC SVMPETEEVV CNNCPPGVTG ARCELCADGY 
       510        520        530        540        550
FGDPFGEHGP VRPCQPCQCN NNVDPSASGN CDRLTGRCLK CIHNTAGIYC 
       560        570        580        590        600
DQCKAGYFGD PLAPNPADKC RACNCNPMGS EPVGCRSDGT CVCKPGFGGP 
       610        620        630        640        650
NCEHGAFSCP ACYNQVKIQM DQFMQQLQRM EALISKAQGG DGVVPDTELE 
       660        670        680        690        700
GRMQQAEQAL QDILRDAQIS EGASRSLGLQ LAKVRSQENS YQSRLDDLKM 
       710        720        730        740        750
TVERVRALGS QYQNRVRDTH RLITQMQLSL AESEASLGNT NIPASDHYVG 
       760        770        780        790        800
PNGFKSLAQE ATRLAESHVE SASNMEQLTR ETEDYSKQAL SLVRKALHEG 
       810        820        830        840        850
VGSGSGSPDG AVVQGLVEKL EKTKSLAQQL TREATQAEIE ADRSYQHSLR 
       860        870        880        890        900
LLDSVSRLQG VSDQSFQVEE AKRIKQKADS LSSLVTRHMD EFKRTQKNLG 
       910        920        930        940        950
NWKEEAQQLL QNGKSGREKS DQLLSRANLA KSRAQEALSM GNATFYEVES 
       960        970        980        990       1000
ILKNLREFDL QVDNRKAEAE EAMKRLSYIS QKVSDASDKT QQAERALGSA 
      1010       1020       1030       1040       1050
AADAQRAKNG AGEALEISSE IEQEIGSLNL EANVTADGAL AMEKGLASLK 
      1060       1070       1080       1090       1100
SEMREVEGEL ERKELEFDTN MDAVQMVITE AQKVDTRAKN AGVTIQDTLN 
      1110       1120       1130       1140       1150
TLDGLLHLMD QPLSVDEEGL VLLEQKLSRA KTQINSQLRP MMSELEERAR 
      1160       1170       1180       1190 
QQRGHLHLLE TSIDGILADV KNLENIRDNL PPGCYNTQAL EQQ
Length:1,193
Mass (Da):130,976
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BBE1A56516C5C9A
GO
Isoform Short (identifier: Q13753-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1110-1193: DQPLSVDEEG...CYNTQALEQQ → GM

Show »
Length:1,111
Mass (Da):121,604
Checksum:i7762993F3D7F89DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12F → L in CAA52108 (PubMed:8306988).Curated1
Sequence conflicti473M → I in CAA78728 (PubMed:1383240).Curated1
Sequence conflicti473M → I in CAA78729 (PubMed:1383240).Curated1
Sequence conflicti521N → S in CAA78728 (PubMed:1383240).Curated1
Sequence conflicti521N → S in CAA78729 (PubMed:1383240).Curated1
Sequence conflicti857R → P in CAA78728 (PubMed:1383240).Curated1
Sequence conflicti857R → P in CAA78729 (PubMed:1383240).Curated1
Sequence conflicti883S → T in AAC50457 (PubMed:8786121).Curated1
Sequence conflicti883S → T in AAC50456 (PubMed:8786121).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050081111A → P. Corresponds to variant dbSNP:rs12065473EnsemblClinVar.1
Natural variantiVAR_050082115R → Q. Corresponds to variant dbSNP:rs17481405EnsemblClinVar.1
Natural variantiVAR_050083124T → M. Corresponds to variant dbSNP:rs11586699EnsemblClinVar.1
Natural variantiVAR_050084136D → V. Corresponds to variant dbSNP:rs12037099EnsemblClinVar.1
Natural variantiVAR_022017247D → E. Corresponds to variant dbSNP:rs2296306EnsemblClinVar.1
Natural variantiVAR_050085608S → I. Corresponds to variant dbSNP:rs4373715Ensembl.1
Natural variantiVAR_020304733S → T. Corresponds to variant dbSNP:rs2296303EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0030401110 – 1193DQPLS…ALEQQ → GM in isoform Short. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z15008 mRNA Translation: CAA78728.1
Z15009 mRNA Translation: CAA78729.1
X73902 mRNA Translation: CAA52108.1
U31201 U31199 Genomic DNA Translation: AAC50457.1
U31200 U31198 Genomic DNA Translation: AAC50456.1
AL354953 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91146.1
BC112286 mRNA Translation: AAI12287.1
BC113378 mRNA Translation: AAI13379.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1352.1 [Q13753-1]
CCDS44285.1 [Q13753-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A44018

NCBI Reference Sequences

More...RefSeqi		NP_005553.2, NM_005562.2 [Q13753-1]
NP_061486.2, NM_018891.2 [Q13753-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264144; ENSP00000264144; ENSG00000058085 [Q13753-1]
ENST00000493293; ENSP00000432063; ENSG00000058085 [Q13753-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3918

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3918

UCSC genome browser

More...UCSCi		uc001gpz.5, human [Q13753-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15008 mRNA Translation: CAA78728.1
Z15009 mRNA Translation: CAA78729.1
X73902 mRNA Translation: CAA52108.1
U31201 U31199 Genomic DNA Translation: AAC50457.1
U31200 U31198 Genomic DNA Translation: AAC50456.1
AL354953 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91146.1
BC112286 mRNA Translation: AAI12287.1
BC113378 mRNA Translation: AAI13379.1
CCDSiCCDS1352.1 [Q13753-1]
CCDS44285.1 [Q13753-2]
PIRiA44018
RefSeqiNP_005553.2, NM_005562.2 [Q13753-1]
NP_061486.2, NM_018891.2 [Q13753-2]

3D structure databases

SMRiQ13753
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110112, 9 interactors
ComplexPortaliCPX-1774, Laminin-332 complex variant A
CPX-1783, Laminin-522 complex
CPX-3165, Laminin-332 complex variant B
IntActiQ13753, 2 interactors
MINTiQ13753
STRINGi9606.ENSP00000264144

Chemistry databases

ChEMBLiCHEMBL2364187

Protein family/group databases

Allergomei8331, Hom s Laminin gamma_2

PTM databases

GlyConnecti1445, 2 N-Linked glycans (2 sites)
GlyGeniQ13753, 4 sites
iPTMnetiQ13753
MetOSiteiQ13753
PhosphoSitePlusiQ13753

Polymorphism and mutation databases

BioMutaiLAMC2
DMDMi90185107

Proteomic databases

EPDiQ13753
jPOSTiQ13753
MassIVEiQ13753
MaxQBiQ13753
PaxDbiQ13753
PeptideAtlasiQ13753
PRIDEiQ13753
ProteomicsDBi59675 [Q13753-1]
59676 [Q13753-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3791, 265 antibodies

Genome annotation databases

EnsembliENST00000264144; ENSP00000264144; ENSG00000058085 [Q13753-1]
ENST00000493293; ENSP00000432063; ENSG00000058085 [Q13753-2]
GeneIDi3918
KEGGihsa:3918
UCSCiuc001gpz.5, human [Q13753-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3918
DisGeNETi3918
EuPathDBiHostDB:ENSG00000058085.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		LAMC2
GeneReviewsiLAMC2
HGNCiHGNC:6493, LAMC2
HPAiENSG00000058085, Low tissue specificity
MalaCardsiLAMC2
MIMi150292, gene
226700, phenotype
neXtProtiNX_Q13753
OpenTargetsiENSG00000058085
Orphaneti79405, Junctional epidermolysis bullosa inversa
79402, Junctional epidermolysis bullosa, generalized intermediate
79404, Junctional epidermolysis bullosa, generalized severe
PharmGKBiPA30281

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1836, Eukaryota
GeneTreeiENSGT00940000160470
HOGENOMiCLU_002471_0_0_1
InParanoidiQ13753
KOiK06246
OMAiGECYSGD
OrthoDBi156553at2759
PhylomeDBiQ13753

Enzyme and pathway databases

PathwayCommonsiQ13753
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix
R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures
R-HSA-2214320, Anchoring fibril formation
R-HSA-3000157, Laminin interactions
R-HSA-3000171, Non-integrin membrane-ECM interactions
R-HSA-446107, Type I hemidesmosome assembly
R-HSA-8874081, MET activates PTK2 signaling
SIGNORiQ13753

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3918, 2 hits in 863 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LAMC2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Laminin,_gamma_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3918
PharosiQ13753, Tbio

Protein Ontology

More...PROi		PR:Q13753
RNActiQ13753, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000058085, Expressed in islet of Langerhans and 178 other tissues
GenevisibleiQ13753, HS

Family and domain databases

InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR000034, Laminin_IV
PfamiView protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 7 hits
SMARTiView protein in SMART
SM00181, EGF, 6 hits
SM00180, EGF_Lam, 7 hits
SM00281, LamB, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 6 hits
PS50027, EGF_LAM_2, 6 hits
PS51115, LAMININ_IVA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13753
Secondary accession number(s): Q02536
, Q02537, Q13752, Q14941, Q14DF7, Q2M1N2, Q5VYE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 7, 2006
Last modified: October 7, 2020
This is version 202 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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