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Entry version 196 (16 Oct 2019)
Sequence version 2 (07 Mar 2006)
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Protein

Laminin subunit gamma-2

Gene

LAMC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.1 Publication

Miscellaneous

Binds heparin.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2214320 Anchoring fibril formation
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-446107 Type I hemidesmosome assembly
R-HSA-8874081 MET activates PTK2 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13753

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit gamma-2
Alternative name(s):
Cell-scattering factor 140 kDa subunit
Short name:
CSF 140 kDa subunit
Epiligrin subunit gamma
Kalinin subunit gamma
Kalinin/nicein/epiligrin 100 kDa subunit
Ladsin 140 kDa subunit
Laminin B2t chain
Laminin-5 subunit gamma
Large adhesive scatter factor 140 kDa subunit
Nicein subunit gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMC2
Synonyms:LAMB2T, LAMNB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6493 LAMC2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
150292 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13753

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epidermolysis bullosa, junctional, Herlitz type (H-JEB)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infantile and lethal form of junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement In the Herlitz type, death occurs usually within the first six months of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic.
Related information in OMIM

Keywords - Diseasei

Epidermolysis bullosa

Organism-specific databases

DisGeNET

More...
DisGeNETi
3918

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
LAMC2

MalaCards human disease database

More...
MalaCardsi
LAMC2
MIMi226700 phenotype

Open Targets

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OpenTargetsi
ENSG00000058085

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79405 Junctional epidermolysis bullosa inversa
79402 Junctional epidermolysis bullosa, generalized intermediate
79404 Junctional epidermolysis bullosa, generalized severe

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30281

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13753

Protein family/group databases

Allergome; a platform for allergen knowledge

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Allergomei
8331 Hom s Laminin gamma_2

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2364187

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
LAMC2

Domain mapping of disease mutations (DMDM)

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DMDMi
90185107

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001707722 – 1193Laminin subunit gamma-2Add BLAST1172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 37PROSITE-ProRule annotation
Disulfide bondi30 ↔ 53PROSITE-ProRule annotation
Disulfide bondi56 ↔ 65PROSITE-ProRule annotation
Disulfide bondi68 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 96PROSITE-ProRule annotation
Disulfide bondi86 ↔ 102PROSITE-ProRule annotation
Disulfide bondi104 ↔ 113PROSITE-ProRule annotation
Disulfide bondi116 ↔ 128PROSITE-ProRule annotation
Disulfide bondi139 ↔ 150PROSITE-ProRule annotation
Disulfide bondi141 ↔ 155PROSITE-ProRule annotation
Disulfide bondi157 ↔ 166PROSITE-ProRule annotation
Disulfide bondi169 ↔ 184PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi462 ↔ 470PROSITE-ProRule annotation
Disulfide bondi464 ↔ 481PROSITE-ProRule annotation
Disulfide bondi484 ↔ 493PROSITE-ProRule annotation
Disulfide bondi496 ↔ 514PROSITE-ProRule annotation
Disulfide bondi517 ↔ 531PROSITE-ProRule annotation
Disulfide bondi519 ↔ 538PROSITE-ProRule annotation
Disulfide bondi541 ↔ 550PROSITE-ProRule annotation
Disulfide bondi553 ↔ 570PROSITE-ProRule annotation
Disulfide bondi573 ↔ 585PROSITE-ProRule annotation
Disulfide bondi575 ↔ 591PROSITE-ProRule annotation
Disulfide bondi593 ↔ 602PROSITE-ProRule annotation
Disulfide bondi609InterchainCurated
Disulfide bondi612InterchainCurated
Glycosylationi942N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1033N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1184InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13753

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13753

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13753

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13753

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13753

PeptideAtlas

More...
PeptideAtlasi
Q13753

PRoteomics IDEntifications database

More...
PRIDEi
Q13753

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
59675 [Q13753-1]
59676 [Q13753-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1445

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13753

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13753

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q13753

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000058085 Expressed in 163 organ(s), highest expression level in islet of Langerhans

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13753 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB004257
CAB078165
HPA024638

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-2 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110112, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1774 Laminin-332 complex variant A
CPX-1783 Laminin-522 complex
CPX-3165 Laminin-332 complex variant B

Protein interaction database and analysis system

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IntActi
Q13753, 2 interactors

Molecular INTeraction database

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MINTi
Q13753

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264144

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13753

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 83Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini84 – 130Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST47
Domaini139 – 186Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST48
Domaini187 – 196Laminin EGF-like 4; first partPROSITE-ProRule annotation10
Domaini213 – 381Laminin IV type APROSITE-ProRule annotationAdd BLAST169
Domaini382 – 415Laminin EGF-like 4; second partPROSITE-ProRule annotationAdd BLAST34
Domaini416 – 461Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST46
Domaini462 – 516Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST55
Domaini517 – 572Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST56
Domaini573 – 602Laminin EGF-like 8; truncatedPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni603 – 1193Domain II and IAdd BLAST591

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili611 – 718Sequence analysisAdd BLAST108
Coiled coili811 – 1076Sequence analysisAdd BLAST266
Coiled coili1117 – 1193Sequence analysisAdd BLAST77

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain IV is globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IP6C Eukaryota
ENOG4110QI9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160470

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000019301

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13753

KEGG Orthology (KO)

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KOi
K06246

Identification of Orthologs from Complete Genome Data

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OMAi
FRAKTQI

Database of Orthologous Groups

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OrthoDBi
1504122at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13753

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 6 hits
SM00180 EGF_Lam, 7 hits
SM00281 LamB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 6 hits
PS50027 EGF_LAM_2, 6 hits
PS51115 LAMININ_IVA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: Q13753-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPALWLGCCL CFSLLLPAAR ATSRREVCDC NGKSRQCIFD RELHRQTGNG
60 70 80 90 100
FRCLNCNDNT DGIHCEKCKN GFYRHRERDR CLPCNCNSKG SLSARCDNSG
110 120 130 140 150
RCSCKPGVTG ARCDRCLPGF HMLTDAGCTQ DQRLLDSKCD CDPAGIAGPC
160 170 180 190 200
DAGRCVCKPA VTGERCDRCR SGYYNLDGGN PEGCTQCFCY GHSASCRSSA
210 220 230 240 250
EYSVHKITST FHQDVDGWKA VQRNGSPAKL QWSQRHQDVF SSAQRLDPVY
260 270 280 290 300
FVAPAKFLGN QQVSYGQSLS FDYRVDRGGR HPSAHDVILE GAGLRITAPL
310 320 330 340 350
MPLGKTLPCG LTKTYTFRLN EHPSNNWSPQ LSYFEYRRLL RNLTALRIRA
360 370 380 390 400
TYGEYSTGYI DNVTLISARP VSGAPAPWVE QCICPVGYKG QFCQDCASGY
410 420 430 440 450
KRDSARLGPF GTCIPCNCQG GGACDPDTGD CYSGDENPDI ECADCPIGFY
460 470 480 490 500
NDPHDPRSCK PCPCHNGFSC SVMPETEEVV CNNCPPGVTG ARCELCADGY
510 520 530 540 550
FGDPFGEHGP VRPCQPCQCN NNVDPSASGN CDRLTGRCLK CIHNTAGIYC
560 570 580 590 600
DQCKAGYFGD PLAPNPADKC RACNCNPMGS EPVGCRSDGT CVCKPGFGGP
610 620 630 640 650
NCEHGAFSCP ACYNQVKIQM DQFMQQLQRM EALISKAQGG DGVVPDTELE
660 670 680 690 700
GRMQQAEQAL QDILRDAQIS EGASRSLGLQ LAKVRSQENS YQSRLDDLKM
710 720 730 740 750
TVERVRALGS QYQNRVRDTH RLITQMQLSL AESEASLGNT NIPASDHYVG
760 770 780 790 800
PNGFKSLAQE ATRLAESHVE SASNMEQLTR ETEDYSKQAL SLVRKALHEG
810 820 830 840 850
VGSGSGSPDG AVVQGLVEKL EKTKSLAQQL TREATQAEIE ADRSYQHSLR
860 870 880 890 900
LLDSVSRLQG VSDQSFQVEE AKRIKQKADS LSSLVTRHMD EFKRTQKNLG
910 920 930 940 950
NWKEEAQQLL QNGKSGREKS DQLLSRANLA KSRAQEALSM GNATFYEVES
960 970 980 990 1000
ILKNLREFDL QVDNRKAEAE EAMKRLSYIS QKVSDASDKT QQAERALGSA
1010 1020 1030 1040 1050
AADAQRAKNG AGEALEISSE IEQEIGSLNL EANVTADGAL AMEKGLASLK
1060 1070 1080 1090 1100
SEMREVEGEL ERKELEFDTN MDAVQMVITE AQKVDTRAKN AGVTIQDTLN
1110 1120 1130 1140 1150
TLDGLLHLMD QPLSVDEEGL VLLEQKLSRA KTQINSQLRP MMSELEERAR
1160 1170 1180 1190
QQRGHLHLLE TSIDGILADV KNLENIRDNL PPGCYNTQAL EQQ
Length:1,193
Mass (Da):130,976
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BBE1A56516C5C9A
GO
Isoform Short (identifier: Q13753-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1110-1193: DQPLSVDEEG...CYNTQALEQQ → GM

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Length:1,111
Mass (Da):121,604
Checksum:i7762993F3D7F89DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12F → L in CAA52108 (PubMed:8306988).Curated1
Sequence conflicti473M → I in CAA78728 (PubMed:1383240).Curated1
Sequence conflicti473M → I in CAA78729 (PubMed:1383240).Curated1
Sequence conflicti521N → S in CAA78728 (PubMed:1383240).Curated1
Sequence conflicti521N → S in CAA78729 (PubMed:1383240).Curated1
Sequence conflicti857R → P in CAA78728 (PubMed:1383240).Curated1
Sequence conflicti857R → P in CAA78729 (PubMed:1383240).Curated1
Sequence conflicti883S → T in AAC50457 (PubMed:8786121).Curated1
Sequence conflicti883S → T in AAC50456 (PubMed:8786121).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050081111A → P. Corresponds to variant dbSNP:rs12065473EnsemblClinVar.1
Natural variantiVAR_050082115R → Q. Corresponds to variant dbSNP:rs17481405EnsemblClinVar.1
Natural variantiVAR_050083124T → M. Corresponds to variant dbSNP:rs11586699EnsemblClinVar.1
Natural variantiVAR_050084136D → V. Corresponds to variant dbSNP:rs12037099EnsemblClinVar.1
Natural variantiVAR_022017247D → E. Corresponds to variant dbSNP:rs2296306EnsemblClinVar.1
Natural variantiVAR_050085608S → I. Corresponds to variant dbSNP:rs4373715Ensembl.1
Natural variantiVAR_020304733S → T. Corresponds to variant dbSNP:rs2296303EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0030401110 – 1193DQPLS…ALEQQ → GM in isoform Short. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z15008 mRNA Translation: CAA78728.1
Z15009 mRNA Translation: CAA78729.1
X73902 mRNA Translation: CAA52108.1
U31201
, U31178, U31179, U31180, U31181, U31182, U31183, U31184, U31186, U31187, U31188, U31189, U31190, U31191, U31192, U31193, U31194, U31195, U31196, U31197, U31198, U31199 Genomic DNA Translation: AAC50457.1
U31200
, U31178, U31179, U31180, U31181, U31182, U31183, U31184, U31186, U31187, U31188, U31189, U31190, U31191, U31192, U31193, U31194, U31195, U31196, U31197, U31198 Genomic DNA Translation: AAC50456.1
AL354953 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91146.1
BC112286 mRNA Translation: AAI12287.1
BC113378 mRNA Translation: AAI13379.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1352.1 [Q13753-1]
CCDS44285.1 [Q13753-2]

Protein sequence database of the Protein Information Resource

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PIRi
A44018

NCBI Reference Sequences

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RefSeqi
NP_005553.2, NM_005562.2 [Q13753-1]
NP_061486.2, NM_018891.2 [Q13753-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264144; ENSP00000264144; ENSG00000058085 [Q13753-1]
ENST00000493293; ENSP00000432063; ENSG00000058085 [Q13753-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3918

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3918

UCSC genome browser

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UCSCi
uc001gpz.5 human [Q13753-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15008 mRNA Translation: CAA78728.1
Z15009 mRNA Translation: CAA78729.1
X73902 mRNA Translation: CAA52108.1
U31201
, U31178, U31179, U31180, U31181, U31182, U31183, U31184, U31186, U31187, U31188, U31189, U31190, U31191, U31192, U31193, U31194, U31195, U31196, U31197, U31198, U31199 Genomic DNA Translation: AAC50457.1
U31200
, U31178, U31179, U31180, U31181, U31182, U31183, U31184, U31186, U31187, U31188, U31189, U31190, U31191, U31192, U31193, U31194, U31195, U31196, U31197, U31198 Genomic DNA Translation: AAC50456.1
AL354953 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91146.1
BC112286 mRNA Translation: AAI12287.1
BC113378 mRNA Translation: AAI13379.1
CCDSiCCDS1352.1 [Q13753-1]
CCDS44285.1 [Q13753-2]
PIRiA44018
RefSeqiNP_005553.2, NM_005562.2 [Q13753-1]
NP_061486.2, NM_018891.2 [Q13753-2]

3D structure databases

SMRiQ13753
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110112, 9 interactors
ComplexPortaliCPX-1774 Laminin-332 complex variant A
CPX-1783 Laminin-522 complex
CPX-3165 Laminin-332 complex variant B
IntActiQ13753, 2 interactors
MINTiQ13753
STRINGi9606.ENSP00000264144

Chemistry databases

ChEMBLiCHEMBL2364187

Protein family/group databases

Allergomei8331 Hom s Laminin gamma_2

PTM databases

GlyConnecti1445
iPTMnetiQ13753
PhosphoSitePlusiQ13753

Polymorphism and mutation databases

BioMutaiLAMC2
DMDMi90185107

Proteomic databases

EPDiQ13753
jPOSTiQ13753
MassIVEiQ13753
MaxQBiQ13753
PaxDbiQ13753
PeptideAtlasiQ13753
PRIDEiQ13753
ProteomicsDBi59675 [Q13753-1]
59676 [Q13753-2]

Genome annotation databases

EnsembliENST00000264144; ENSP00000264144; ENSG00000058085 [Q13753-1]
ENST00000493293; ENSP00000432063; ENSG00000058085 [Q13753-2]
GeneIDi3918
KEGGihsa:3918
UCSCiuc001gpz.5 human [Q13753-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3918
DisGeNETi3918

GeneCards: human genes, protein and diseases

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GeneCardsi
LAMC2
GeneReviewsiLAMC2
HGNCiHGNC:6493 LAMC2
HPAiCAB004257
CAB078165
HPA024638
MalaCardsiLAMC2
MIMi150292 gene
226700 phenotype
neXtProtiNX_Q13753
OpenTargetsiENSG00000058085
Orphaneti79405 Junctional epidermolysis bullosa inversa
79402 Junctional epidermolysis bullosa, generalized intermediate
79404 Junctional epidermolysis bullosa, generalized severe
PharmGKBiPA30281

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IP6C Eukaryota
ENOG4110QI9 LUCA
GeneTreeiENSGT00940000160470
HOGENOMiHOG000019301
InParanoidiQ13753
KOiK06246
OMAiFRAKTQI
OrthoDBi1504122at2759
PhylomeDBiQ13753

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2214320 Anchoring fibril formation
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-446107 Type I hemidesmosome assembly
R-HSA-8874081 MET activates PTK2 signaling
SIGNORiQ13753

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LAMC2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Laminin,_gamma_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3918
PharosiQ13753
PMAP-CutDBiQ13753

Protein Ontology

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PROi
PR:Q13753

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000058085 Expressed in 163 organ(s), highest expression level in islet of Langerhans
GenevisibleiQ13753 HS

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
PfamiView protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 7 hits
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00180 EGF_Lam, 7 hits
SM00281 LamB, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 6 hits
PS50027 EGF_LAM_2, 6 hits
PS51115 LAMININ_IVA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13753
Secondary accession number(s): Q02536
, Q02537, Q13752, Q14941, Q14DF7, Q2M1N2, Q5VYE8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 7, 2006
Last modified: October 16, 2019
This is version 196 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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