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UniProtKB - Q13751 (LAMB3_HUMAN)

Protein

Laminin subunit beta-3

Gene

LAMB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein-containing complex binding Source: Ensembl
  • structural molecule activity Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • brown fat cell differentiation Source: Ensembl
  • cell adhesion Source: UniProtKB-KW
  • endodermal cell differentiation Source: UniProtKB
  • epidermis development Source: ProtInc
  • extracellular matrix organization Source: Reactome
  • hemidesmosome assembly Source: Reactome
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2214320 Anchoring fibril formation
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-446107 Type I hemidesmosome assembly
R-HSA-8874081 MET activates PTK2 signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13751

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit beta-3
Alternative name(s):
Epiligrin subunit bata
Kalinin B1 chain
Kalinin subunit beta
Laminin B1k chain
Laminin-5 subunit beta
Nicein subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMB3
Synonyms:LAMNB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000196878.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:6490 LAMB3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		150310 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13751

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epidermolysis bullosa, junctional, Herlitz type (H-JEB)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infantile and lethal form of junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement In the Herlitz type, death occurs usually within the first six months of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic.
See also OMIM:226700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_004171679P → L in H-JEB. 1 PublicationCorresponds to variant dbSNP:rs201223111EnsemblClinVar.1
Generalized atrophic benign epidermolysis bullosa (GABEB)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
See also OMIM:226650
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037310199G → A in GABEB; somatic second-site mutation. 1 PublicationCorresponds to variant dbSNP:rs121912486EnsemblClinVar.1
Natural variantiVAR_037311207K → Q in GABEB; somatic second-site mutation. 1 PublicationCorresponds to variant dbSNP:rs121912487EnsemblClinVar.1
Natural variantiVAR_004170210E → K in GABEB. 2 PublicationsCorresponds to variant dbSNP:rs121912482EnsemblClinVar.1
Amelogenesis imperfecta 1A (AI1A)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of amelogenesis imperfecta, a disorder characterized by defective enamel formation. The enamel may be hypoplastic, hypomineralized or both, and affected teeth may be discoloured, sensitive or prone to disintegration.
See also OMIM:104530

Keywords - Diseasei

Amelogenesis imperfecta, Disease mutation, Epidermolysis bullosa

Organism-specific databases

DisGeNET

More...DisGeNETi		3914

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		LAMB3

MalaCards human disease database

More...MalaCardsi		LAMB3
MIMi104530 phenotype
226650 phenotype
226700 phenotype

Open Targets

More...OpenTargetsi		ENSG00000196878

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		100031 Hypoplastic amelogenesis imperfecta
79402 Junctional epidermolysis bullosa, generalized intermediate
79404 Junctional epidermolysis bullosa, generalized severe

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30278

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2364187

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LAMB3

Domain mapping of disease mutations (DMDM)

More...DMDMi		2497600

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001707118 – 1172Laminin subunit beta-3Add BLAST1155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi250 ↔ 259PROSITE-ProRule annotation
Disulfide bondi252 ↔ 279PROSITE-ProRule annotation
Disulfide bondi281 ↔ 290PROSITE-ProRule annotation
Disulfide bondi293 ↔ 313PROSITE-ProRule annotation
Disulfide bondi316 ↔ 325PROSITE-ProRule annotation
Disulfide bondi318 ↔ 343PROSITE-ProRule annotation
Disulfide bondi346 ↔ 355PROSITE-ProRule annotation
Disulfide bondi358 ↔ 376PROSITE-ProRule annotation
Disulfide bondi379 ↔ 392PROSITE-ProRule annotation
Disulfide bondi381 ↔ 399PROSITE-ProRule annotation
Disulfide bondi401 ↔ 410PROSITE-ProRule annotation
Disulfide bondi413 ↔ 428PROSITE-ProRule annotation
Disulfide bondi431 ↔ 444PROSITE-ProRule annotation
Disulfide bondi433 ↔ 451PROSITE-ProRule annotation
Disulfide bondi453 ↔ 462PROSITE-ProRule annotation
Disulfide bondi465 ↔ 478PROSITE-ProRule annotation
Disulfide bondi481 ↔ 493PROSITE-ProRule annotation
Disulfide bondi483 ↔ 500PROSITE-ProRule annotation
Disulfide bondi502 ↔ 511PROSITE-ProRule annotation
Disulfide bondi519 ↔ 531PROSITE-ProRule annotation
Disulfide bondi534 ↔ 546PROSITE-ProRule annotation
Disulfide bondi536 ↔ 553PROSITE-ProRule annotation
Disulfide bondi555 ↔ 564PROSITE-ProRule annotation
Disulfide bondi567 ↔ 578PROSITE-ProRule annotation
Disulfide bondi581InterchainCurated
Disulfide bondi584InterchainCurated
Glycosylationi604N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi810N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1171InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13751

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13751

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13751

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13751

PeptideAtlas

More...PeptideAtlasi		Q13751

PRoteomics IDEntifications database

More...PRIDEi		Q13751

ProteomicsDB human proteome resource

More...ProteomicsDBi		59674

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13751

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13751

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q13751

Miscellaneous databases

CutDB - Proteolytic event database

More...PMAP-CutDBi		Q13751

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the basement membranes (major component).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196878 Expressed in 158 organ(s), highest expression level in epithelium of bronchus

CleanEx database of gene expression profiles

More...CleanExi		HS_LAMB3

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13751 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13751 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB078183
HPA008069

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein). Interacts with ECM1.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110108, 23 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1774 Laminin-332 complex variant A
CPX-3165 Laminin-332 complex variant B

Protein interaction database and analysis system

More...IntActi		Q13751, 22 interactors

Molecular INTeraction database

More...MINTi		Q13751

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000348384

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q13751

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13751

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 249Laminin N-terminalPROSITE-ProRule annotationAdd BLAST228
Domaini250 – 315Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST66
Domaini316 – 378Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini379 – 430Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST52
Domaini431 – 480Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST50
Domaini481 – 533Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST53
Domaini534 – 580Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni579 – 785Domain IIAdd BLAST207
Regioni786 – 816Domain alphaAdd BLAST31
Regioni817 – 1170Domain IAdd BLAST354

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili723 – 757Sequence analysisAdd BLAST35
Coiled coili831 – 884Sequence analysisAdd BLAST54
Coiled coili948 – 1133Sequence analysisAdd BLAST186

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain VI is globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0994 Eukaryota
ENOG410XPEG LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160731

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000113279

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG052302

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13751

KEGG Orthology (KO)

More...KOi		K06244

Identification of Orthologs from Complete Genome Data

More...OMAi		ETMEMMD

Database of Orthologous Groups

More...OrthoDBi		88170at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13751

TreeFam database of animal gene trees

More...TreeFami		TF352481

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013032 EGF-like_CS
IPR002049 Laminin_EGF
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00053 Laminin_EGF, 6 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00180 EGF_Lam, 6 hits
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 1 hit
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 6 hits
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q13751-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPFFLLCFA LPGLLHAQQA CSRGACYPPV GDLLVGRTRF LRASSTCGLT 
        60         70         80         90        100
KPETYCTQYG EWQMKCCKCD SRQPHNYYSH RVENVASSSG PMRWWQSQND 
       110        120        130        140        150
VNPVSLQLDL DRRFQLQEVM MEFQGPMPAG MLIERSSDFG KTWRVYQYLA 
       160        170        180        190        200
ADCTSTFPRV RQGRPQSWQD VRCQSLPQRP NARLNGGKVQ LNLMDLVSGI 
       210        220        230        240        250
PATQSQKIQE VGEITNLRVN FTRLAPVPQR GYHPPSAYYA VSQLRLQGSC 
       260        270        280        290        300
FCHGHADRCA PKPGASAGPS TAVQVHDVCV CQHNTAGPNC ERCAPFYNNR 
       310        320        330        340        350
PWRPAEGQDA HECQRCDCNG HSETCHFDPA VFAASQGAYG GVCDNCRDHT 
       360        370        380        390        400
EGKNCERCQL HYFRNRRPGA SIQETCISCE CDPDGAVPGA PCDPVTGQCV 
       410        420        430        440        450
CKEHVQGERC DLCKPGFTGL TYANPQGCHR CDCNILGSRR DMPCDEESGR 
       460        470        480        490        500
CLCLPNVVGP KCDQCAPYHW KLASGQGCEP CACDPHNSLS PQCNQFTGQC 
       510        520        530        540        550
PCREGFGGLM CSAAAIRQCP DRTYGDVATG CRACDCDFRG TEGPGCDKAS 
       560        570        580        590        600
GRCLCRPGLT GPRCDQCQRG YCNRYPVCVA CHPCFQTYDA DLREQALRFG 
       610        620        630        640        650
RLRNATASLW SGPGLEDRGL ASRILDAKSK IEQIRAVLSS PAVTEQEVAQ 
       660        670        680        690        700
VASAILSLRR TLQGLQLDLP LEEETLSLPR DLESLDRSFN GLLTMYQRKR 
       710        720        730        740        750
EQFEKISSAD PSGAFRMLST AYEQSAQAAQ QVSDSSRLLD QLRDSRREAE 
       760        770        780        790        800
RLVRQAGGGG GTGSPKLVAL RLEMSSLPDL TPTFNKLCGN SRQMACTPIS 
       810        820        830        840        850
CPGELCPQDN GTACGSRCRG VLPRAGGAFL MAGQVAEQLR GFNAQLQRTR 
       860        870        880        890        900
QMIRAAEESA SQIQSSAQRL ETQVSASRSQ MEEDVRRTRL LIQQVRDFLT 
       910        920        930        940        950
DPDTDAATIQ EVSEAVLALW LPTDSATVLQ KMNEIQAIAA RLPNVDLVLS 
       960        970        980        990       1000
QTKQDIARAR RLQAEAEEAR SRAHAVEGQV EDVVGNLRQG TVALQEAQDT 
      1010       1020       1030       1040       1050
MQGTSRSLRL IQDRVAEVQQ VLRPAEKLVT SMTKQLGDFW TRMEELRHQA 
      1060       1070       1080       1090       1100
RQQGAEAVQA QQLAEGASEQ ALSAQEGFER IKQKYAELKD RLGQSSMLGE 
      1110       1120       1130       1140       1150
QGARIQSVKT EAEELFGETM EMMDRMKDME LELLRGSQAI MLRSADLTGL 
      1160       1170 
EKRVEQIRDH INGRVLYYAT CK
Length:1,172
Mass (Da):129,572
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61BC1A60BBD4FA05
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5THA1Q5THA1_HUMAN
Laminin subunit beta-3
LAMB3
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X1WI29X1WI29_HUMAN
Laminin subunit beta-3
LAMB3
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti124Q → R in AAA61834 (PubMed:7512558).Curated1
Sequence conflicti269Missing in AAA61834 (PubMed:7512558).Curated1
Sequence conflicti388P → A in AAA61834 (PubMed:7512558).Curated1
Sequence conflicti426 – 427QG → RR in AAA61834 (PubMed:7512558).Curated2
Sequence conflicti440 – 441RD → E in AAA61834 (PubMed:7512558).Curated2
Sequence conflicti489 – 500LSPQC…FTGQC → PQPTVQPVHRAV in BAA22263 (PubMed:8530036).CuratedAdd BLAST12
Sequence conflicti603R → P in AAA61834 (PubMed:7512558).Curated1
Sequence conflicti815G → A in AAA61834 (PubMed:7512558).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037309181N → D. Corresponds to variant dbSNP:rs2235542EnsemblClinVar.1
Natural variantiVAR_037310199G → A in GABEB; somatic second-site mutation. 1 PublicationCorresponds to variant dbSNP:rs121912486EnsemblClinVar.1
Natural variantiVAR_037311207K → Q in GABEB; somatic second-site mutation. 1 PublicationCorresponds to variant dbSNP:rs121912487EnsemblClinVar.1
Natural variantiVAR_004170210E → K in GABEB. 2 PublicationsCorresponds to variant dbSNP:rs121912482EnsemblClinVar.1
Natural variantiVAR_037312292R → L. Corresponds to variant dbSNP:rs12091253Ensembl.1
Natural variantiVAR_034060438S → T. Corresponds to variant dbSNP:rs2229468EnsemblClinVar.1
Natural variantiVAR_035820450R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200895463Ensembl.1
Natural variantiVAR_037313527V → M. Corresponds to variant dbSNP:rs2076349EnsemblClinVar.1
Natural variantiVAR_004171679P → L in H-JEB. 1 PublicationCorresponds to variant dbSNP:rs201223111EnsemblClinVar.1
Natural variantiVAR_034061690N → S. Corresponds to variant dbSNP:rs2229466EnsemblClinVar.1
Natural variantiVAR_034062852M → L1 PublicationCorresponds to variant dbSNP:rs12748250EnsemblClinVar.1
Natural variantiVAR_037314926A → D. Corresponds to variant dbSNP:rs2076222EnsemblClinVar.1
Natural variantiVAR_034063988R → W. Corresponds to variant dbSNP:rs2229467EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L25541 mRNA Translation: AAA61834.1
U17760
, U17745, U17746, U17747, U17748, U17749, U17750, U17751, U17752, U17753, U17754, U17755, U17756, U17757, U17758, U17759 Genomic DNA Translation: AAC51352.1
D37766 mRNA Translation: BAA22263.1
AY035783 mRNA Translation: AAK61364.1
AL023754 Genomic DNA No translation available.
AL031316 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93448.1
CH471100 Genomic DNA Translation: EAW93449.1
BC075838 mRNA Translation: AAH75838.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1487.1

Protein sequence database of the Protein Information Resource

More...PIRi		A53612

NCBI Reference Sequences

More...RefSeqi		NP_000219.2, NM_000228.2
NP_001017402.1, NM_001017402.1
NP_001121113.1, NM_001127641.1
XP_005273181.1, XM_005273124.4

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.497636

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356082; ENSP00000348384; ENSG00000196878
ENST00000367030; ENSP00000355997; ENSG00000196878
ENST00000391911; ENSP00000375778; ENSG00000196878

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3914

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3914

UCSC genome browser

More...UCSCi		uc001hhg.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25541 mRNA Translation: AAA61834.1
U17760
, U17745, U17746, U17747, U17748, U17749, U17750, U17751, U17752, U17753, U17754, U17755, U17756, U17757, U17758, U17759 Genomic DNA Translation: AAC51352.1
D37766 mRNA Translation: BAA22263.1
AY035783 mRNA Translation: AAK61364.1
AL023754 Genomic DNA No translation available.
AL031316 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93448.1
CH471100 Genomic DNA Translation: EAW93449.1
BC075838 mRNA Translation: AAH75838.1
CCDSiCCDS1487.1
PIRiA53612
RefSeqiNP_000219.2, NM_000228.2
NP_001017402.1, NM_001017402.1
NP_001121113.1, NM_001127641.1
XP_005273181.1, XM_005273124.4
UniGeneiHs.497636

3D structure databases

ProteinModelPortaliQ13751
SMRiQ13751
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110108, 23 interactors
ComplexPortaliCPX-1774 Laminin-332 complex variant A
CPX-3165 Laminin-332 complex variant B
IntActiQ13751, 22 interactors
MINTiQ13751
STRINGi9606.ENSP00000348384

Chemistry databases

ChEMBLiCHEMBL2364187

PTM databases

iPTMnetiQ13751
PhosphoSitePlusiQ13751
SwissPalmiQ13751

Polymorphism and mutation databases

BioMutaiLAMB3
DMDMi2497600

Proteomic databases

EPDiQ13751
jPOSTiQ13751
MaxQBiQ13751
PaxDbiQ13751
PeptideAtlasiQ13751
PRIDEiQ13751
ProteomicsDBi59674

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3914
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356082; ENSP00000348384; ENSG00000196878
ENST00000367030; ENSP00000355997; ENSG00000196878
ENST00000391911; ENSP00000375778; ENSG00000196878
GeneIDi3914
KEGGihsa:3914
UCSCiuc001hhg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3914
DisGeNETi3914
EuPathDBiHostDB:ENSG00000196878.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		LAMB3
GeneReviewsiLAMB3
HGNCiHGNC:6490 LAMB3
HPAiCAB078183
HPA008069
MalaCardsiLAMB3
MIMi104530 phenotype
150310 gene
226650 phenotype
226700 phenotype
neXtProtiNX_Q13751
OpenTargetsiENSG00000196878
Orphaneti100031 Hypoplastic amelogenesis imperfecta
79402 Junctional epidermolysis bullosa, generalized intermediate
79404 Junctional epidermolysis bullosa, generalized severe
PharmGKBiPA30278

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
GeneTreeiENSGT00940000160731
HOGENOMiHOG000113279
HOVERGENiHBG052302
InParanoidiQ13751
KOiK06244
OMAiETMEMMD
OrthoDBi88170at2759
PhylomeDBiQ13751
TreeFamiTF352481

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2214320 Anchoring fibril formation
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-446107 Type I hemidesmosome assembly
R-HSA-8874081 MET activates PTK2 signaling
SIGNORiQ13751

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LAMB3 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Laminin,_beta_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3914
PMAP-CutDBiQ13751

Protein Ontology

More...PROi		PR:Q13751

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196878 Expressed in 158 organ(s), highest expression level in epithelium of bronchus
CleanExiHS_LAMB3
ExpressionAtlasiQ13751 baseline and differential
GenevisibleiQ13751 HS

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR002049 Laminin_EGF
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 6 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00180 EGF_Lam, 6 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 1 hit
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 6 hits
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMB3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13751
Secondary accession number(s): D3DT88
, O14947, Q14733, Q9UJK4, Q9UJL1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 16, 2019
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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