UniProtKB - Q13751 (LAMB3_HUMAN)
Protein
Laminin subunit beta-3
Gene
LAMB3
Organism
Homo sapiens (Human)
Status
Functioni
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
GO - Molecular functioni
- extracellular matrix structural constituent Source: GO_Central
- protein-containing complex binding Source: Ensembl
- structural molecule activity Source: ProtInc
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- basement membrane assembly Source: GO_Central
- cell migration Source: GO_Central
- collagen fibril organization Source: Reactome
- endodermal cell differentiation Source: UniProtKB
- epidermis development Source: ProtInc
- extracellular matrix organization Source: Reactome
- hemidesmosome assembly Source: Reactome
- substrate adhesion-dependent cell spreading Source: GO_Central
- tissue development Source: GO_Central
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q13751 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures R-HSA-2214320, Anchoring fibril formation R-HSA-3000157, Laminin interactions R-HSA-3000171, Non-integrin membrane-ECM interactions R-HSA-446107, Type I hemidesmosome assembly R-HSA-8874081, MET activates PTK2 signaling |
SIGNORi | Q13751 |
Names & Taxonomyi
Protein namesi | Recommended name: Laminin subunit beta-3Alternative name(s): Epiligrin subunit bata Kalinin B1 chain Kalinin subunit beta Laminin B1k chain Laminin-5 subunit beta Nicein subunit beta |
Gene namesi | Name:LAMB3 Synonyms:LAMNB1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6490, LAMB3 |
MIMi | 150310, gene |
neXtProti | NX_Q13751 |
VEuPathDBi | HostDB:ENSG00000196878.12 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- laminin complex Source: GO_Central
Keywords - Cellular componenti
Basement membrane, Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Epidermolysis bullosa, junctional, Herlitz type (H-JEB)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn infantile and lethal form of junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement In the Herlitz type, death occurs usually within the first six months of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_004171 | 679 | P → L in H-JEB. 1 PublicationCorresponds to variant dbSNP:rs201223111EnsemblClinVar. | 1 |
Generalized atrophic benign epidermolysis bullosa (GABEB)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037310 | 199 | G → A in GABEB; somatic second-site mutation. 1 PublicationCorresponds to variant dbSNP:rs121912486EnsemblClinVar. | 1 | |
Natural variantiVAR_037311 | 207 | K → Q in GABEB; somatic second-site mutation. 1 PublicationCorresponds to variant dbSNP:rs121912487EnsemblClinVar. | 1 | |
Natural variantiVAR_004170 | 210 | E → K in GABEB. 2 PublicationsCorresponds to variant dbSNP:rs121912482EnsemblClinVar. | 1 |
Amelogenesis imperfecta 1A (AI1A)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of amelogenesis imperfecta, a disorder characterized by defective enamel formation. The enamel may be hypoplastic, hypomineralized or both, and affected teeth may be discoloured, sensitive or prone to disintegration.
Related information in OMIMKeywords - Diseasei
Amelogenesis imperfecta, Disease variant, Epidermolysis bullosaOrganism-specific databases
DisGeNETi | 3914 |
GeneReviewsi | LAMB3 |
MalaCardsi | LAMB3 |
MIMi | 104530, phenotype 226650, phenotype 226700, phenotype |
OpenTargetsi | ENSG00000196878 |
Orphaneti | 100031, Hypoplastic amelogenesis imperfecta 79402, Junctional epidermolysis bullosa, generalized intermediate 79404, Junctional epidermolysis bullosa, generalized severe |
PharmGKBi | PA30278 |
Miscellaneous databases
Pharosi | Q13751, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364187 |
Genetic variation databases
BioMutai | LAMB3 |
DMDMi | 2497600 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000017071 | 18 – 1172 | Laminin subunit beta-3Add BLAST | 1155 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 220 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 250 ↔ 259 | PROSITE-ProRule annotation | ||
Disulfide bondi | 252 ↔ 279 | PROSITE-ProRule annotation | ||
Disulfide bondi | 281 ↔ 290 | PROSITE-ProRule annotation | ||
Disulfide bondi | 293 ↔ 313 | PROSITE-ProRule annotation | ||
Disulfide bondi | 316 ↔ 325 | PROSITE-ProRule annotation | ||
Disulfide bondi | 318 ↔ 343 | PROSITE-ProRule annotation | ||
Disulfide bondi | 346 ↔ 355 | PROSITE-ProRule annotation | ||
Disulfide bondi | 358 ↔ 376 | PROSITE-ProRule annotation | ||
Disulfide bondi | 379 ↔ 392 | PROSITE-ProRule annotation | ||
Disulfide bondi | 381 ↔ 399 | PROSITE-ProRule annotation | ||
Disulfide bondi | 401 ↔ 410 | PROSITE-ProRule annotation | ||
Disulfide bondi | 413 ↔ 428 | PROSITE-ProRule annotation | ||
Disulfide bondi | 431 ↔ 444 | PROSITE-ProRule annotation | ||
Disulfide bondi | 433 ↔ 451 | PROSITE-ProRule annotation | ||
Disulfide bondi | 453 ↔ 462 | PROSITE-ProRule annotation | ||
Disulfide bondi | 465 ↔ 478 | PROSITE-ProRule annotation | ||
Disulfide bondi | 481 ↔ 493 | PROSITE-ProRule annotation | ||
Disulfide bondi | 483 ↔ 500 | PROSITE-ProRule annotation | ||
Disulfide bondi | 502 ↔ 511 | PROSITE-ProRule annotation | ||
Disulfide bondi | 519 ↔ 531 | PROSITE-ProRule annotation | ||
Disulfide bondi | 534 ↔ 546 | PROSITE-ProRule annotation | ||
Disulfide bondi | 536 ↔ 553 | PROSITE-ProRule annotation | ||
Disulfide bondi | 555 ↔ 564 | PROSITE-ProRule annotation | ||
Disulfide bondi | 567 ↔ 578 | PROSITE-ProRule annotation | ||
Disulfide bondi | 581 | InterchainCurated | ||
Disulfide bondi | 584 | InterchainCurated | ||
Glycosylationi | 604 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 810 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1171 | InterchainCurated |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q13751 |
jPOSTi | Q13751 |
MassIVEi | Q13751 |
MaxQBi | Q13751 |
PaxDbi | Q13751 |
PeptideAtlasi | Q13751 |
PRIDEi | Q13751 |
ProteomicsDBi | 59674 |
PTM databases
GlyGeni | Q13751, 3 sites |
iPTMneti | Q13751 |
MetOSitei | Q13751 |
PhosphoSitePlusi | Q13751 |
SwissPalmi | Q13751 |
Expressioni
Tissue specificityi
Found in the basement membranes (major component).
Gene expression databases
Bgeei | ENSG00000196878, Expressed in epithelium of bronchus and 172 other tissues |
ExpressionAtlasi | Q13751, baseline and differential |
Genevisiblei | Q13751, HS |
Organism-specific databases
HPAi | ENSG00000196878, Low tissue specificity |
Interactioni
Subunit structurei
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein).
Interacts with ECM1.
1 PublicationProtein-protein interaction databases
BioGRIDi | 110108, 32 interactors |
ComplexPortali | CPX-1774, Laminin-332 complex variant A CPX-3165, Laminin-332 complex variant B |
IntActi | Q13751, 23 interactors |
MINTi | Q13751 |
STRINGi | 9606.ENSP00000375778 |
Miscellaneous databases
RNActi | Q13751, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 249 | Laminin N-terminalPROSITE-ProRule annotationAdd BLAST | 228 | |
Domaini | 250 – 315 | Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST | 66 | |
Domaini | 316 – 378 | Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 379 – 430 | Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 431 – 480 | Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 481 – 533 | Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 534 – 580 | Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST | 47 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 579 – 785 | Domain IIAdd BLAST | 207 | |
Regioni | 786 – 816 | Domain alphaAdd BLAST | 31 | |
Regioni | 817 – 1170 | Domain IAdd BLAST | 354 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 723 – 757 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 831 – 884 | Sequence analysisAdd BLAST | 54 | |
Coiled coili | 948 – 1133 | Sequence analysisAdd BLAST | 186 |
Domaini
The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain VI is globular.
Keywords - Domaini
Coiled coil, Laminin EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG0994, Eukaryota |
GeneTreei | ENSGT00940000160731 |
HOGENOMi | CLU_001560_0_0_1 |
InParanoidi | Q13751 |
OMAi | GSQAIML |
OrthoDBi | 88170at2759 |
PhylomeDBi | Q13751 |
TreeFami | TF352481 |
Family and domain databases
Gene3Di | 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR002049, Laminin_EGF IPR008211, Laminin_N IPR038684, Laminin_N_sf |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 6 hits PF00055, Laminin_N, 1 hit |
SMARTi | View protein in SMART SM00180, EGF_Lam, 6 hits SM00136, LamNT, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 5 hits PS01186, EGF_2, 1 hit PS01248, EGF_LAM_1, 5 hits PS50027, EGF_LAM_2, 6 hits PS51117, LAMININ_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q13751-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPFFLLCFA LPGLLHAQQA CSRGACYPPV GDLLVGRTRF LRASSTCGLT
60 70 80 90 100
KPETYCTQYG EWQMKCCKCD SRQPHNYYSH RVENVASSSG PMRWWQSQND
110 120 130 140 150
VNPVSLQLDL DRRFQLQEVM MEFQGPMPAG MLIERSSDFG KTWRVYQYLA
160 170 180 190 200
ADCTSTFPRV RQGRPQSWQD VRCQSLPQRP NARLNGGKVQ LNLMDLVSGI
210 220 230 240 250
PATQSQKIQE VGEITNLRVN FTRLAPVPQR GYHPPSAYYA VSQLRLQGSC
260 270 280 290 300
FCHGHADRCA PKPGASAGPS TAVQVHDVCV CQHNTAGPNC ERCAPFYNNR
310 320 330 340 350
PWRPAEGQDA HECQRCDCNG HSETCHFDPA VFAASQGAYG GVCDNCRDHT
360 370 380 390 400
EGKNCERCQL HYFRNRRPGA SIQETCISCE CDPDGAVPGA PCDPVTGQCV
410 420 430 440 450
CKEHVQGERC DLCKPGFTGL TYANPQGCHR CDCNILGSRR DMPCDEESGR
460 470 480 490 500
CLCLPNVVGP KCDQCAPYHW KLASGQGCEP CACDPHNSLS PQCNQFTGQC
510 520 530 540 550
PCREGFGGLM CSAAAIRQCP DRTYGDVATG CRACDCDFRG TEGPGCDKAS
560 570 580 590 600
GRCLCRPGLT GPRCDQCQRG YCNRYPVCVA CHPCFQTYDA DLREQALRFG
610 620 630 640 650
RLRNATASLW SGPGLEDRGL ASRILDAKSK IEQIRAVLSS PAVTEQEVAQ
660 670 680 690 700
VASAILSLRR TLQGLQLDLP LEEETLSLPR DLESLDRSFN GLLTMYQRKR
710 720 730 740 750
EQFEKISSAD PSGAFRMLST AYEQSAQAAQ QVSDSSRLLD QLRDSRREAE
760 770 780 790 800
RLVRQAGGGG GTGSPKLVAL RLEMSSLPDL TPTFNKLCGN SRQMACTPIS
810 820 830 840 850
CPGELCPQDN GTACGSRCRG VLPRAGGAFL MAGQVAEQLR GFNAQLQRTR
860 870 880 890 900
QMIRAAEESA SQIQSSAQRL ETQVSASRSQ MEEDVRRTRL LIQQVRDFLT
910 920 930 940 950
DPDTDAATIQ EVSEAVLALW LPTDSATVLQ KMNEIQAIAA RLPNVDLVLS
960 970 980 990 1000
QTKQDIARAR RLQAEAEEAR SRAHAVEGQV EDVVGNLRQG TVALQEAQDT
1010 1020 1030 1040 1050
MQGTSRSLRL IQDRVAEVQQ VLRPAEKLVT SMTKQLGDFW TRMEELRHQA
1060 1070 1080 1090 1100
RQQGAEAVQA QQLAEGASEQ ALSAQEGFER IKQKYAELKD RLGQSSMLGE
1110 1120 1130 1140 1150
QGARIQSVKT EAEELFGETM EMMDRMKDME LELLRGSQAI MLRSADLTGL
1160 1170
EKRVEQIRDH INGRVLYYAT CK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5THA1 | Q5THA1_HUMAN | Laminin subunit beta-3 | LAMB3 | 188 | Annotation score: | ||
X1WI29 | X1WI29_HUMAN | Laminin subunit beta-3 | LAMB3 | 159 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 124 | Q → R in AAA61834 (PubMed:7512558).Curated | 1 | |
Sequence conflicti | 269 | Missing in AAA61834 (PubMed:7512558).Curated | 1 | |
Sequence conflicti | 388 | P → A in AAA61834 (PubMed:7512558).Curated | 1 | |
Sequence conflicti | 426 – 427 | QG → RR in AAA61834 (PubMed:7512558).Curated | 2 | |
Sequence conflicti | 440 – 441 | RD → E in AAA61834 (PubMed:7512558).Curated | 2 | |
Sequence conflicti | 489 – 500 | LSPQC…FTGQC → PQPTVQPVHRAV in BAA22263 (PubMed:8530036).CuratedAdd BLAST | 12 | |
Sequence conflicti | 603 | R → P in AAA61834 (PubMed:7512558).Curated | 1 | |
Sequence conflicti | 815 | G → A in AAA61834 (PubMed:7512558).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037309 | 181 | N → D. Corresponds to variant dbSNP:rs2235542EnsemblClinVar. | 1 | |
Natural variantiVAR_037310 | 199 | G → A in GABEB; somatic second-site mutation. 1 PublicationCorresponds to variant dbSNP:rs121912486EnsemblClinVar. | 1 | |
Natural variantiVAR_037311 | 207 | K → Q in GABEB; somatic second-site mutation. 1 PublicationCorresponds to variant dbSNP:rs121912487EnsemblClinVar. | 1 | |
Natural variantiVAR_004170 | 210 | E → K in GABEB. 2 PublicationsCorresponds to variant dbSNP:rs121912482EnsemblClinVar. | 1 | |
Natural variantiVAR_037312 | 292 | R → L. Corresponds to variant dbSNP:rs12091253EnsemblClinVar. | 1 | |
Natural variantiVAR_034060 | 438 | S → T. Corresponds to variant dbSNP:rs2229468EnsemblClinVar. | 1 | |
Natural variantiVAR_035820 | 450 | R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200895463EnsemblClinVar. | 1 | |
Natural variantiVAR_037313 | 527 | V → M. Corresponds to variant dbSNP:rs2076349EnsemblClinVar. | 1 | |
Natural variantiVAR_004171 | 679 | P → L in H-JEB. 1 PublicationCorresponds to variant dbSNP:rs201223111EnsemblClinVar. | 1 | |
Natural variantiVAR_034061 | 690 | N → S. Corresponds to variant dbSNP:rs2229466EnsemblClinVar. | 1 | |
Natural variantiVAR_034062 | 852 | M → L1 PublicationCorresponds to variant dbSNP:rs12748250EnsemblClinVar. | 1 | |
Natural variantiVAR_037314 | 926 | A → D. Corresponds to variant dbSNP:rs2076222EnsemblClinVar. | 1 | |
Natural variantiVAR_034063 | 988 | R → W. Corresponds to variant dbSNP:rs2229467EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L25541 mRNA Translation: AAA61834.1 U17760 , U17745, U17746, U17747, U17748, U17749, U17750, U17751, U17752, U17753, U17754, U17755, U17756, U17757, U17758, U17759 Genomic DNA Translation: AAC51352.1 D37766 mRNA Translation: BAA22263.1 AY035783 mRNA Translation: AAK61364.1 AL023754 Genomic DNA No translation available. AL031316 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93448.1 CH471100 Genomic DNA Translation: EAW93449.1 BC075838 mRNA Translation: AAH75838.1 |
CCDSi | CCDS1487.1 |
PIRi | A53612 |
RefSeqi | NP_000219.2, NM_000228.2 NP_001017402.1, NM_001017402.1 NP_001121113.1, NM_001127641.1 XP_005273181.1, XM_005273124.4 |
Genome annotation databases
Ensembli | ENST00000356082; ENSP00000348384; ENSG00000196878 ENST00000367030; ENSP00000355997; ENSG00000196878 ENST00000391911; ENSP00000375778; ENSG00000196878 |
GeneIDi | 3914 |
KEGGi | hsa:3914 |
UCSCi | uc001hhg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L25541 mRNA Translation: AAA61834.1 U17760 , U17745, U17746, U17747, U17748, U17749, U17750, U17751, U17752, U17753, U17754, U17755, U17756, U17757, U17758, U17759 Genomic DNA Translation: AAC51352.1 D37766 mRNA Translation: BAA22263.1 AY035783 mRNA Translation: AAK61364.1 AL023754 Genomic DNA No translation available. AL031316 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93448.1 CH471100 Genomic DNA Translation: EAW93449.1 BC075838 mRNA Translation: AAH75838.1 |
CCDSi | CCDS1487.1 |
PIRi | A53612 |
RefSeqi | NP_000219.2, NM_000228.2 NP_001017402.1, NM_001017402.1 NP_001121113.1, NM_001127641.1 XP_005273181.1, XM_005273124.4 |
3D structure databases
SMRi | Q13751 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110108, 32 interactors |
ComplexPortali | CPX-1774, Laminin-332 complex variant A CPX-3165, Laminin-332 complex variant B |
IntActi | Q13751, 23 interactors |
MINTi | Q13751 |
STRINGi | 9606.ENSP00000375778 |
Chemistry databases
ChEMBLi | CHEMBL2364187 |
PTM databases
GlyGeni | Q13751, 3 sites |
iPTMneti | Q13751 |
MetOSitei | Q13751 |
PhosphoSitePlusi | Q13751 |
SwissPalmi | Q13751 |
Genetic variation databases
BioMutai | LAMB3 |
DMDMi | 2497600 |
Proteomic databases
EPDi | Q13751 |
jPOSTi | Q13751 |
MassIVEi | Q13751 |
MaxQBi | Q13751 |
PaxDbi | Q13751 |
PeptideAtlasi | Q13751 |
PRIDEi | Q13751 |
ProteomicsDBi | 59674 |
Protocols and materials databases
Antibodypediai | 1958, 372 antibodies |
DNASUi | 3914 |
Genome annotation databases
Ensembli | ENST00000356082; ENSP00000348384; ENSG00000196878 ENST00000367030; ENSP00000355997; ENSG00000196878 ENST00000391911; ENSP00000375778; ENSG00000196878 |
GeneIDi | 3914 |
KEGGi | hsa:3914 |
UCSCi | uc001hhg.4, human |
Organism-specific databases
CTDi | 3914 |
DisGeNETi | 3914 |
GeneCardsi | LAMB3 |
GeneReviewsi | LAMB3 |
HGNCi | HGNC:6490, LAMB3 |
HPAi | ENSG00000196878, Low tissue specificity |
MalaCardsi | LAMB3 |
MIMi | 104530, phenotype 150310, gene 226650, phenotype 226700, phenotype |
neXtProti | NX_Q13751 |
OpenTargetsi | ENSG00000196878 |
Orphaneti | 100031, Hypoplastic amelogenesis imperfecta 79402, Junctional epidermolysis bullosa, generalized intermediate 79404, Junctional epidermolysis bullosa, generalized severe |
PharmGKBi | PA30278 |
VEuPathDBi | HostDB:ENSG00000196878.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0994, Eukaryota |
GeneTreei | ENSGT00940000160731 |
HOGENOMi | CLU_001560_0_0_1 |
InParanoidi | Q13751 |
OMAi | GSQAIML |
OrthoDBi | 88170at2759 |
PhylomeDBi | Q13751 |
TreeFami | TF352481 |
Enzyme and pathway databases
PathwayCommonsi | Q13751 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures R-HSA-2214320, Anchoring fibril formation R-HSA-3000157, Laminin interactions R-HSA-3000171, Non-integrin membrane-ECM interactions R-HSA-446107, Type I hemidesmosome assembly R-HSA-8874081, MET activates PTK2 signaling |
SIGNORi | Q13751 |
Miscellaneous databases
BioGRID-ORCSi | 3914, 6 hits in 988 CRISPR screens |
ChiTaRSi | LAMB3, human |
GeneWikii | Laminin,_beta_3 |
GenomeRNAii | 3914 |
Pharosi | Q13751, Tbio |
PROi | PR:Q13751 |
RNActi | Q13751, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196878, Expressed in epithelium of bronchus and 172 other tissues |
ExpressionAtlasi | Q13751, baseline and differential |
Genevisiblei | Q13751, HS |
Family and domain databases
Gene3Di | 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR002049, Laminin_EGF IPR008211, Laminin_N IPR038684, Laminin_N_sf |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 6 hits PF00055, Laminin_N, 1 hit |
SMARTi | View protein in SMART SM00180, EGF_Lam, 6 hits SM00136, LamNT, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 5 hits PS01186, EGF_2, 1 hit PS01248, EGF_LAM_1, 5 hits PS50027, EGF_LAM_2, 6 hits PS51117, LAMININ_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAMB3_HUMAN | |
Accessioni | Q13751Primary (citable) accession number: Q13751 Secondary accession number(s): D3DT88 Q9UJL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 202 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot