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UniProtKB - Q13724 (MOGS_HUMAN)

Entry version 191 (10 Feb 2021)
Sequence version 5 (17 Oct 2006)
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Protein

Mannosyl-oligosaccharide glucosidase

Gene

MOGS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves the distal alpha 1,2-linked glucose residue from the Glc3Man9GlcNAc2 oligosaccharide precursor in a highly specific manner.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: N-glycan degradation

This protein is involved in the pathway N-glycan degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway N-glycan degradation and in Glycan metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glucosidase activity Source: ProtInc
  • mannosyl-oligosaccharide glucosidase activity Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS03863-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13724

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-4793954, Defective MOGS causes MOGS-CDG (CDG-2b)
R-HSA-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-HSA-9683686, Maturation of spike protein
R-HSA-9694548, Maturation of spike protein

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00280

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH63, Glycoside Hydrolase Family 63

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mannosyl-oligosaccharide glucosidase (EC:3.2.1.106)
Alternative name(s):
Processing A-glucosidase I
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MOGS
Synonyms:GCS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24862, MOGS

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601336, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13724

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000115275.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini60 – 837LumenalSequence analysisAdd BLAST778

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Type IIb congenital disorder of glycosylation (CDGIIb)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionCharacterized by marked generalized hypotonia and hypomotility of the neonate, dysmorphic features, including a prominent occiput, short palpebral fissures, retrognathia, high arched palate, generalized edema, and hypoplastic genitalia. Symptoms of the infant included hepatomegaly, hypoventilation, feeding problems and seizures. The clinical course was progressive and the infant did not survive more than a few months.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018966486R → T in CDGIIb; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs121909291EnsemblClinVar.1
Natural variantiVAR_018967652F → L in CDGIIb; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs121909292EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		7841

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		MOGS

MalaCards human disease database

More...MalaCardsi		MOGS
MIMi606056, phenotype

Open Targets

More...OpenTargetsi		ENSG00000115275

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		79330, MOGS-CDG

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164723075

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13724, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4684

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MOGS

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242490

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000577101 – 837Mannosyl-oligosaccharide glucosidaseAdd BLAST837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi657N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13724

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13724

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13724

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13724

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13724

PeptideAtlas

More...PeptideAtlasi		Q13724

PRoteomics IDEntifications database

More...PRIDEi		Q13724

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		27150
59667 [Q13724-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1489, 6 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q13724, 1 site, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13724

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13724

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q13724

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000115275, Expressed in left lobe of thyroid gland and 175 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13724, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13724, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000115275, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113599, 116 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q13724

Protein interaction database and analysis system

More...IntActi		Q13724, 33 interactors

Molecular INTeraction database

More...MINTi		Q13724

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000233616

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13724, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13724

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 137Required for endoplasmic reticulum targetingBy similarityAdd BLAST62

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi3 – 9Endoplasmic reticulum targeting7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 63 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2161, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017452

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007380_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13724

Identification of Orthologs from Complete Genome Data

More...OMAi		PLYMKRN

Database of Orthologous Groups

More...OrthoDBi		278028at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13724

TreeFam database of animal gene trees

More...TreeFami		TF300749

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.50.10.10, 1 hit
2.70.98.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008928, 6-hairpin_glycosidase_sf
IPR012341, 6hp_glycosidase-like_sf
IPR031335, Glyco_hydro_63_C
IPR031631, Glyco_hydro_63N
IPR038518, Glyco_hydro_63N_sf
IPR004888, Glycoside_hydrolase_63

The PANTHER Classification System

More...PANTHERi		PTHR10412, PTHR10412, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03200, Glyco_hydro_63, 1 hit
PF16923, Glyco_hydro_63N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48208, SSF48208, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13724-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARGERRRRA VPAEGVRTAE RAARGGPGRR DGRGGGPRST AGGVALAVVV 
        60         70         80         90        100
LSLALGMSGR WVLAWYRARR AVTLHSAPPV LPADSSSPAV APDLFWGTYR 
       110        120        130        140        150
PHVYFGMKTR SPKPLLTGLM WAQQGTTPGT PKLRHTCEQG DGVGPYGWEF 
       160        170        180        190        200
HDGLSFGRQH IQDGALRLTT EFVKRPGGQH GGDWSWRVTV EPQDSGTSAL 
       210        220        230        240        250
PLVSLFFYVV TDGKEVLLPE VGAKGQLKFI SGHTSELGDF RFTLLPPTSP 
       260        270        280        290        300
GDTAPKYGSY NVFWTSNPGL PLLTEMVKSR LNSWFQHRPP GAPPERYLGL 
       310        320        330        340        350
PGSLKWEDRG PSGQGQGQFL IQQVTLKIPI SIEFVFESGS AQAGGNQALP 
       360        370        380        390        400
RLAGSLLTQA LESHAEGFRE RFEKTFQLKE KGLSSGEQVL GQAALSGLLG 
       410        420        430        440        450
GIGYFYGQGL VLPDIGVEGS EQKVDPALFP PVPLFTAVPS RSFFPRGFLW 
       460        470        480        490        500
DEGFHQLVVQ RWDPSLTREA LGHWLGLLNA DGWIGREQIL GDEARARVPP 
       510        520        530        540        550
EFLVQRAVHA NPPTLLLPVA HMLEVGDPDD LAFLRKALPR LHAWFSWLHQ 
       560        570        580        590        600
SQAGPLPLSY RWRGRDPALP TLLNPKTLPS GLDDYPRASH PSVTERHLDL 
       610        620        630        640        650
RCWVALGARV LTRLAEHLGE AEVAAELGPL AASLEAAESL DELHWAPELG 
       660        670        680        690        700
VFADFGNHTK AVQLKPRPPQ GLVRVVGRPQ PQLQYVDALG YVSLFPLLLR 
       710        720        730        740        750
LLDPTSSRLG PLLDILADSR HLWSPFGLRS LAASSSFYGQ RNSEHDPPYW 
       760        770        780        790        800
RGAVWLNVNY LALGALHHYG HLEGPHQARA AKLHGELRAN VVGNVWRQYQ 
       810        820        830 
ATGFLWEQYS DRDGRGMGCR PFHGWTSLVL LAMAEDY
Length:837
Mass (Da):91,918
Last modified:October 17, 2006 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11C5B09301B50DEE
GO
Isoform 2 (identifier: Q13724-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:731
Mass (Da):80,703
Checksum:iB9B38429664731E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IS52A0A3B3IS52_HUMAN
Mannosyl-oligosaccharide glucosidas...
MOGS
428Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZE2B8ZZE2_HUMAN
Mannosyl-oligosaccharide glucosidas...
MOGS
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITC1A0A3B3ITC1_HUMAN
Mannosyl-oligosaccharide glucosidas...
MOGS
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITU6A0A3B3ITU6_HUMAN
Mannosyl-oligosaccharide glucosidas...
MOGS
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRK6A0A3B3IRK6_HUMAN
Mannosyl-oligosaccharide glucosidas...
MOGS
715Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4E3B8B4E3B8_HUMAN
Mannosyl-oligosaccharide glucosidas...
MOGS
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRW2A0A3B3IRW2_HUMAN
Mannosyl-oligosaccharide glucosidas...
MOGS
562Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRI7A0A3B3IRI7_HUMAN
Mannosyl-oligosaccharide glucosidas...
MOGS
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDQ1C9JDQ1_HUMAN
Mannosyl-oligosaccharide glucosidas...
MOGS
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRI1A0A3B3IRI1_HUMAN
Mannosyl-oligosaccharide glucosidas...
MOGS
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti330I → F in CAA60683 (PubMed:7635146).Curated1
Sequence conflicti389V → A in CAA60683 (PubMed:7635146).Curated1
Sequence conflicti605A → G in CAA60683 (PubMed:7635146).Curated1
Sequence conflicti818Missing in CAA60683 (PubMed:7635146).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049233222G → R. Corresponds to variant dbSNP:rs3213671EnsemblClinVar.1
Natural variantiVAR_019361236E → Q1 PublicationCorresponds to variant dbSNP:rs1063587Ensembl.1
Natural variantiVAR_019362239D → N1 PublicationCorresponds to variant dbSNP:rs1063588EnsemblClinVar.1
Natural variantiVAR_049234293P → S1 PublicationCorresponds to variant dbSNP:rs2268416EnsemblClinVar.1
Natural variantiVAR_018966486R → T in CDGIIb; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs121909291EnsemblClinVar.1
Natural variantiVAR_049235495R → P. Corresponds to variant dbSNP:rs34075781Ensembl.1
Natural variantiVAR_018967652F → L in CDGIIb; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs121909292EnsemblClinVar.1
Natural variantiVAR_049236785G → S. Corresponds to variant dbSNP:rs35533773EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469211 – 106Missing in isoform 2. CuratedAdd BLAST106

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X87237 mRNA Translation: CAA60683.1
AJ422288 Genomic DNA Translation: CAD19636.1
AK292553 mRNA Translation: BAF85242.1
AC005041 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99653.1
BC117252 mRNA Translation: AAI17253.1
BC117250 mRNA Translation: AAI17251.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42700.1 [Q13724-1]
CCDS54370.1 [Q13724-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S66258

NCBI Reference Sequences

More...RefSeqi		NP_001139630.1, NM_001146158.1 [Q13724-2]
NP_006293.2, NM_006302.2 [Q13724-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000448666; ENSP00000410992; ENSG00000115275 [Q13724-1]
ENST00000452063; ENSP00000388201; ENSG00000115275 [Q13724-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7841

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7841

UCSC genome browser

More...UCSCi		uc010ffi.4, human [Q13724-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87237 mRNA Translation: CAA60683.1
AJ422288 Genomic DNA Translation: CAD19636.1
AK292553 mRNA Translation: BAF85242.1
AC005041 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99653.1
BC117252 mRNA Translation: AAI17253.1
BC117250 mRNA Translation: AAI17251.1
CCDSiCCDS42700.1 [Q13724-1]
CCDS54370.1 [Q13724-2]
PIRiS66258
RefSeqiNP_001139630.1, NM_001146158.1 [Q13724-2]
NP_006293.2, NM_006302.2 [Q13724-1]

3D structure databases

SMRiQ13724
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113599, 116 interactors
ELMiQ13724
IntActiQ13724, 33 interactors
MINTiQ13724
STRINGi9606.ENSP00000233616

Chemistry databases

ChEMBLiCHEMBL4684

Protein family/group databases

CAZyiGH63, Glycoside Hydrolase Family 63

PTM databases

GlyConnecti1489, 6 N-Linked glycans (1 site)
GlyGeniQ13724, 1 site, 1 N-linked glycan (1 site)
iPTMnetiQ13724
PhosphoSitePlusiQ13724
SwissPalmiQ13724

Genetic variation databases

BioMutaiMOGS
DMDMi116242490

Proteomic databases

EPDiQ13724
jPOSTiQ13724
MassIVEiQ13724
MaxQBiQ13724
PaxDbiQ13724
PeptideAtlasiQ13724
PRIDEiQ13724
ProteomicsDBi27150
59667 [Q13724-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2372, 180 antibodies

Genome annotation databases

EnsembliENST00000448666; ENSP00000410992; ENSG00000115275 [Q13724-1]
ENST00000452063; ENSP00000388201; ENSG00000115275 [Q13724-2]
GeneIDi7841
KEGGihsa:7841
UCSCiuc010ffi.4, human [Q13724-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7841
DisGeNETi7841

GeneCards: human genes, protein and diseases

More...GeneCardsi		MOGS
GeneReviewsiMOGS
HGNCiHGNC:24862, MOGS
HPAiENSG00000115275, Low tissue specificity
MalaCardsiMOGS
MIMi601336, gene
606056, phenotype
neXtProtiNX_Q13724
OpenTargetsiENSG00000115275
Orphaneti79330, MOGS-CDG
PharmGKBiPA164723075
VEuPathDBiHostDB:ENSG00000115275.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2161, Eukaryota
GeneTreeiENSGT00390000017452
HOGENOMiCLU_007380_1_0_1
InParanoidiQ13724
OMAiPLYMKRN
OrthoDBi278028at2759
PhylomeDBiQ13724
TreeFamiTF300749

Enzyme and pathway databases

UniPathwayiUPA00280
BioCyciMetaCyc:HS03863-MONOMER
PathwayCommonsiQ13724
ReactomeiR-HSA-4793954, Defective MOGS causes MOGS-CDG (CDG-2b)
R-HSA-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-HSA-9683686, Maturation of spike protein
R-HSA-9694548, Maturation of spike protein

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7841, 48 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MOGS, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GCS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7841
PharosiQ13724, Tbio

Protein Ontology

More...PROi		PR:Q13724
RNActiQ13724, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000115275, Expressed in left lobe of thyroid gland and 175 other tissues
ExpressionAtlasiQ13724, baseline and differential
GenevisibleiQ13724, HS

Family and domain databases

Gene3Di1.50.10.10, 1 hit
2.70.98.110, 1 hit
InterProiView protein in InterPro
IPR008928, 6-hairpin_glycosidase_sf
IPR012341, 6hp_glycosidase-like_sf
IPR031335, Glyco_hydro_63_C
IPR031631, Glyco_hydro_63N
IPR038518, Glyco_hydro_63N_sf
IPR004888, Glycoside_hydrolase_63
PANTHERiPTHR10412, PTHR10412, 1 hit
PfamiView protein in Pfam
PF03200, Glyco_hydro_63, 1 hit
PF16923, Glyco_hydro_63N, 1 hit
SUPFAMiSSF48208, SSF48208, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOGS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13724
Secondary accession number(s): A8K938
, F5H6D0, Q17RN9, Q8TCT5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: February 10, 2021
This is version 191 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  7. SIMILARITY comments
    Index of protein domains and families
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