RAPSN

Functionⁱ

Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	363 – 403	RING-typePROSITE-ProRule annotationAdd BLAST		41

GO - Molecular functionⁱ

acetylcholine receptor binding
Source: MGI
Inferred from direct assayⁱ
- 18420419
ionotropic glutamate receptor binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
protein membrane anchor Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 8812503
establishment of protein localization to postsynaptic membrane Source: Ensembl
positive regulation of neuromuscular synaptic transmission Source: Ensembl
positive regulation of neuron apoptotic process Source: Ensembl
regulation of postsynaptic membrane organization Source: Ensembl
synaptic transmission, cholinergic
Source: MGI
Inferred from genetic interactionⁱ
- 18420419

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 43 kDa receptor-associated protein of the synapse Short name: RAPsyn Alternative name(s): 43 kDa postsynaptic protein Acetylcholine receptor-associated 43 kDa protein RING finger protein 205
Gene namesⁱ	Name:RAPSN Synonyms:RNF205
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165917.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9863 RAPSN
MIMⁱ	601592 gene
neXtProtⁱ	NX_Q13702

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Myasthenic syndrome, congenital, 11, associated with acetylcholine receptor deficiency (CMS11)9 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS11 is an autosomal recessive disorder of postsynaptic neuromuscular transmission, due to deficiency of AChR at the endplate that results in low amplitude of the miniature endplate potential and current.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021216	14	L → P in CMS11. 3 PublicationsCorresponds to variant dbSNP:rs104894300EnsemblClinVar.	1
Natural variantⁱVAR_043898	45	V → M in CMS11; reduced coclustering with acetylcholine receptor. 1 PublicationCorresponds to variant dbSNP:rs121909254EnsemblClinVar.	1
Natural variantⁱVAR_021217	88	N → K in CMS11. 7 PublicationsCorresponds to variant dbSNP:rs104894299EnsemblClinVar.	1
Natural variantⁱVAR_043900	162	E → K in CMS11; reduced coclustering with acetylcholine receptor. 1 PublicationCorresponds to variant dbSNP:rs121909255EnsemblClinVar.	1
Natural variantⁱVAR_043901	164	R → C in CMS11; reduced coclustering with acetylcholine receptor. 1 PublicationCorresponds to variant dbSNP:rs104894294EnsemblClinVar.	1
Natural variantⁱVAR_043903	283	L → P in CMS11; reduced coclustering with acetylcholine receptor. 1 PublicationCorresponds to variant dbSNP:rs104894293EnsemblClinVar.	1

Fetal akinesia deformation sequence (FADS)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA clinically and genetically heterogeneous group of disorders with congenital malformations related to impaired fetal movement. Clinical features include fetal akinesia, intrauterine growth retardation, polyhydramnios, arthrogryposis, pulmonary hypoplasia, craniofacial abnormalities, and cryptorchidism.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_043899	139	F → S in FADS. 1 PublicationCorresponds to variant dbSNP:rs121909256EnsemblClinVar.		1
Natural variantⁱVAR_043902	189	A → V in FADS. 1 PublicationCorresponds to variant dbSNP:rs121909257EnsemblClinVar.		1

Keywords - Diseaseⁱ

Congenital myasthenic syndrome, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5913
GeneReviewsⁱ	RAPSN
MalaCards human disease database More...MalaCardsⁱ	RAPSN
MIMⁱ	208150 phenotype 616326 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000165917
Orphanetⁱ	994 Fetal akinesia deformation sequence 33108 Lethal multiple pterygium syndrome 98913 Postsynaptic congenital myasthenic syndromes
PharmGKBⁱ	PA34224

Chemistry databases

ChEMBLⁱ	CHEMBL2163166

ChEMBLⁱ

CHEMBL2163166

Polymorphism and mutation databases

BioMutaⁱ	RAPSN
DMDMⁱ	145559521

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000167591	2 – 412	43 kDa receptor-associated protein of the synapseAdd BLAST		411

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycineBy similarity	1
Modified residueⁱ	196	PhosphotyrosineSequence analysis	1
Modified residueⁱ	405	PhosphoserineSequence analysis	1

Post-translational modificationⁱ

Ubiquitinated by the BCR(KLHL8) complex, leading to its degradation.1 Publication

Keywords - PTMⁱ

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q13702
PeptideAtlas More...PeptideAtlasⁱ	Q13702
PRIDEⁱ	Q13702
ProteomicsDBⁱ	59664 59665 [Q13702-2]

PTM databases

iPTMnetⁱ	Q13702
PhosphoSitePlusⁱ	Q13702

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000165917 Expressed in 87 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_RAPSN
ExpressionAtlasⁱ	Q13702 baseline and differential
Genevisibleⁱ	Q13702 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039475

HPAⁱ

HPA039475

Interactionⁱ

GO - Molecular functionⁱ

acetylcholine receptor binding
Source: MGI
Inferred from direct assayⁱ
- 18420419
ionotropic glutamate receptor binding Source: Ensembl
protein membrane anchor Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111848, 7 interactors
IntActⁱ	Q13702, 2 interactors
STRINGⁱ	9606.ENSP00000298854

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13702
SMRⁱ	Q13702
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	6 – 39	TPR 1Add BLAST	34
Repeatⁱ	83 – 116	TPR 2Add BLAST	34
Repeatⁱ	123 – 156	TPR 3Add BLAST	34
Repeatⁱ	163 – 196	TPR 4Add BLAST	34
Repeatⁱ	206 – 239	TPR 5Add BLAST	34
Repeatⁱ	246 – 279	TPR 6Add BLAST	34
Repeatⁱ	286 – 319	TPR 7Add BLAST	34

Domainⁱ

A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer.

Sequence similaritiesⁱ

Belongs to the RAPsyn family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	363 – 403	RING-typePROSITE-ProRule annotationAdd BLAST		41

Keywords - Domainⁱ

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1941 Eukaryota ENOG41103HX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016785
HOGENOMⁱ	HOG000231395
HOVERGENⁱ	HBG061484
InParanoidⁱ	Q13702
OMAⁱ	AHNNDDK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03VV
PhylomeDBⁱ	Q13702
TreeFamⁱ	TF328344

Family and domain databases

Gene3Dⁱ	1.25.40.10, 2 hits 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001237 Postsynaptic IPR018293 Postsynaptic_CS IPR019568 Rapsyn_myristoylation/link_N IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR019734 TPR_repeat IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10579 Rapsyn_N, 1 hit PF13639 zf-RING_2, 1 hit
PRINTSⁱ	PR00217 POSTSYNAPTIC
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit SM00028 TPR, 7 hits
SUPFAMⁱ	SSF48452 SSF48452, 3 hits
PROSITEⁱ	View protein in PROSITE PS00405 43_KD_POSTSYNAPTIC, 1 hit PS50005 TPR, 5 hits PS50293 TPR_REGION, 1 hit PS50089 ZF_RING_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q13702-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQDQTKQQI EKGLQLYQSN QTEKALQVWT KVLEKSSDLM GRFRVLGCLV 
        60         70         80         90        100
TAHSEMGRYK EMLKFAVVQI DTARELEDAD FLLESYLNLA RSNEKLCEFH 
       110        120        130        140        150
KTISYCKTCL GLPGTRAGAQ LGGQVSLSMG NAFLGLSVFQ KALESFEKAL 
       160        170        180        190        200
RYAHNNDDAM LECRVCCSLG SFYAQVKDYE KALFFPCKAA ELVNNYGKGW 
       210        220        230        240        250
SLKYRAMSQY HMAVAYRLLG RLGSAMECCE ESMKIALQHG DRPLQALCLL 
       260        270        280        290        300
CFADIHRSRG DLETAFPRYD SAMSIMTEIG NRLGQVQALL GVAKCWVARK 
       310        320        330        340        350
ALDKALDAIE RAQDLAEEVG NKLSQLKLHC LSESIYRSKG LQRELRAHVV 
       360        370        380        390        400
RFHECVEETE LYCGLCGESI GEKNSRLQAL PCSHIFHLRC LQNNGTRSCP 
       410 
NCRRSSMKPG FV

Length:412

Mass (Da):46,328

Last modified:April 17, 2007 - v4

Checksum:ⁱD17AC566700F5AAF

GO

Isoform 2 (identifier: Q13702-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
264-322: Missing.

« Hide

        10         20         30         40         50
MGQDQTKQQI EKGLQLYQSN QTEKALQVWT KVLEKSSDLM GRFRVLGCLV 
        60         70         80         90        100
TAHSEMGRYK EMLKFAVVQI DTARELEDAD FLLESYLNLA RSNEKLCEFH 
       110        120        130        140        150
KTISYCKTCL GLPGTRAGAQ LGGQVSLSMG NAFLGLSVFQ KALESFEKAL 
       160        170        180        190        200
RYAHNNDDAM LECRVCCSLG SFYAQVKDYE KALFFPCKAA ELVNNYGKGW 
       210        220        230        240        250
SLKYRAMSQY HMAVAYRLLG RLGSAMECCE ESMKIALQHG DRPLQALCLL 
       260        270        280        290        300
CFADIHRSRG DLELSQLKLH CLSESIYRSK GLQRELRAHV VRFHECVEET 
       310        320        330        340        350
ELYCGLCGES IGEKNSRLQA LPCSHIFHLR CLQNNGTRSC PNCRRSSMKP 

GFV

Note: No experimental confirmation available.

Show »

Length:353

Mass (Da):39,912

Checksum:ⁱ79A95D25A1FAA69A

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PJP9	E9PJP9_HUMAN	43 kDa receptor-associated protein ... 43 kDa receptor-associated protein of the synapse	RAPSN	359	Annotation score:
E9PK11	E9PK11_HUMAN	43 kDa receptor-associated protein ... 43 kDa receptor-associated protein of the synapse	RAPSN	353	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	112	L → V in CAA83954 (PubMed:8812503).Curated	1
Sequence conflictⁱ	159	A → T in CAA83954 (PubMed:8812503).Curated	1
Sequence conflictⁱ	205	R → Q in CAA83954 (PubMed:8812503).Curated	1
Sequence conflictⁱ	364	G → A in CAA83954 (PubMed:8812503).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_043897	8	Q → K1 PublicationCorresponds to variant dbSNP:rs11556408Ensembl.	1
Natural variantⁱVAR_021216	14	L → P in CMS11. 3 PublicationsCorresponds to variant dbSNP:rs104894300EnsemblClinVar.	1
Natural variantⁱVAR_043898	45	V → M in CMS11; reduced coclustering with acetylcholine receptor. 1 PublicationCorresponds to variant dbSNP:rs121909254EnsemblClinVar.	1
Natural variantⁱVAR_062142	81	F → L. Corresponds to variant dbSNP:rs57878668EnsemblClinVar.	1
Natural variantⁱVAR_021217	88	N → K in CMS11. 7 PublicationsCorresponds to variant dbSNP:rs104894299EnsemblClinVar.	1
Natural variantⁱVAR_043899	139	F → S in FADS. 1 PublicationCorresponds to variant dbSNP:rs121909256EnsemblClinVar.	1
Natural variantⁱVAR_043900	162	E → K in CMS11; reduced coclustering with acetylcholine receptor. 1 PublicationCorresponds to variant dbSNP:rs121909255EnsemblClinVar.	1
Natural variantⁱVAR_043901	164	R → C in CMS11; reduced coclustering with acetylcholine receptor. 1 PublicationCorresponds to variant dbSNP:rs104894294EnsemblClinVar.	1
Natural variantⁱVAR_043902	189	A → V in FADS. 1 PublicationCorresponds to variant dbSNP:rs121909257EnsemblClinVar.	1
Natural variantⁱVAR_043903	283	L → P in CMS11; reduced coclustering with acetylcholine receptor. 1 PublicationCorresponds to variant dbSNP:rs104894293EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005533	264 – 322	Missing in isoform 2. 1 PublicationAdd BLAST		59

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z33905 mRNA Translation: CAA83954.1 AF449218 mRNA Translation: AAL86639.1 CH471064 Genomic DNA Translation: EAW67914.1 BC004196 mRNA Translation: AAH04196.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7936.1 [Q13702-1] CCDS7937.1 [Q13702-2]
PIRⁱ	S45064
NCBI Reference Sequences More...RefSeqⁱ	NP_005046.2, NM_005055.4 [Q13702-1] NP_116034.2, NM_032645.4 [Q13702-2]
UniGeneⁱ	Hs.81218

Genome annotation databases

Ensemblⁱ	ENST00000298854; ENSP00000298854; ENSG00000165917 [Q13702-1] ENST00000352508; ENSP00000298853; ENSG00000165917 [Q13702-2]
GeneIDⁱ	5913
KEGGⁱ	hsa:5913
UCSC genome browser More...UCSCⁱ	uc001nfi.2 human [Q13702-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13702	Receptor-associated protein of the synapse isoform 3 (Fragment)		HUMAN		412	UniRef100_Q13702
Q13702-2	Receptor-associated protein of the synapse isoform 1 (Fragment)		HUMAN		353	UniRef100_Q13702-2

Protein	Similar proteins		Species	Score	Length	Source
Q13702	43 kDa receptor-associated protein of the synapse		MOUSE		412	UniRef90_Q13702
Receptor-associated protein of the synapse isoform 3 (Fragment)		HUMAN		412
43 kDa receptor-associated protein of the synapse		PTEAL		419
Receptor associated protein of the synapse		SAIBB		412
Uncharacterized protein		LOXAF		412
+105
Q13702-2	Receptor-associated protein of the synapse isoform 1 (Fragment)		HUMAN		353	UniRef90_Q13702-2
43 kDa receptor-associated protein of the synapse isoform X3		ERIEU		371
RAPSN isoform 3		PANTR		353
43 kDa receptor-associated protein of the synapse isoform X2		PHYCD		353
Uncharacterized protein		MACMU		353
+55

Protein	Similar proteins		Species	Score	Length	Source
Q13702	43 kDa receptor-associated protein of the synapse		MOUSE		412	UniRef50_Q13702
43 kDa receptor-associated protein of the synapse		CHICK		412
Receptor-associated protein of the synapse isoform 3 (Fragment)		HUMAN		412
43 kDa receptor-associated protein of the synapse		PTEAL		419
Uncharacterized protein		LOXAF		412
+314
Q13702-2	Receptor-associated protein of the synapse isoform 1 (Fragment)		HUMAN		353	UniRef50_Q13702-2
43 kDa receptor-associated protein of the synapse isoform X3		ERIEU		371
Receptor associated protein of the synapse		SAIBB		353
43 kDa receptor-associated protein of the synapse		MOUSE		353
43 kDa receptor-associated protein of the synapse isoform X2		NEOSC		353
+122

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z33905 mRNA Translation: CAA83954.1 AF449218 mRNA Translation: AAL86639.1 CH471064 Genomic DNA Translation: EAW67914.1 BC004196 mRNA Translation: AAH04196.1
CCDSⁱ	CCDS7936.1 [Q13702-1] CCDS7937.1 [Q13702-2]
PIRⁱ	S45064
RefSeqⁱ	NP_005046.2, NM_005055.4 [Q13702-1] NP_116034.2, NM_032645.4 [Q13702-2]
UniGeneⁱ	Hs.81218

3D structure databases

ProteinModelPortalⁱ	Q13702
SMRⁱ	Q13702
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111848, 7 interactors
IntActⁱ	Q13702, 2 interactors
STRINGⁱ	9606.ENSP00000298854

Chemistry databases

ChEMBLⁱ	CHEMBL2163166

ChEMBLⁱ

CHEMBL2163166

PTM databases

iPTMnetⁱ	Q13702
PhosphoSitePlusⁱ	Q13702

Polymorphism and mutation databases

BioMutaⁱ	RAPSN
DMDMⁱ	145559521

Proteomic databases

PaxDbⁱ	Q13702
PeptideAtlasⁱ	Q13702
PRIDEⁱ	Q13702
ProteomicsDBⁱ	59664 59665 [Q13702-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000298854; ENSP00000298854; ENSG00000165917 [Q13702-1] ENST00000352508; ENSP00000298853; ENSG00000165917 [Q13702-2]
GeneIDⁱ	5913
KEGGⁱ	hsa:5913
UCSCⁱ	uc001nfi.2 human [Q13702-1]

Organism-specific databases

CTDⁱ	5913
DisGeNETⁱ	5913
EuPathDBⁱ	HostDB:ENSG00000165917.9
GeneCardsⁱ	RAPSN
GeneReviewsⁱ	RAPSN
HGNCⁱ	HGNC:9863 RAPSN
HPAⁱ	HPA039475
MalaCardsⁱ	RAPSN
MIMⁱ	208150 phenotype 601592 gene 616326 phenotype
neXtProtⁱ	NX_Q13702
OpenTargetsⁱ	ENSG00000165917
Orphanetⁱ	994 Fetal akinesia deformation sequence 33108 Lethal multiple pterygium syndrome 98913 Postsynaptic congenital myasthenic syndromes
PharmGKBⁱ	PA34224
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1941 Eukaryota ENOG41103HX LUCA
GeneTreeⁱ	ENSGT00390000016785
HOGENOMⁱ	HOG000231395
HOVERGENⁱ	HBG061484
InParanoidⁱ	Q13702
OMAⁱ	AHNNDDK
OrthoDBⁱ	EOG091G03VV
PhylomeDBⁱ	Q13702
TreeFamⁱ	TF328344

Miscellaneous databases

GeneWikiⁱ	RAPSN
GenomeRNAiⁱ	5913
Protein Ontology More...PROⁱ	PR:Q13702
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165917 Expressed in 87 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_RAPSN
ExpressionAtlasⁱ	Q13702 baseline and differential
Genevisibleⁱ	Q13702 HS

Family and domain databases

Gene3Dⁱ	1.25.40.10, 2 hits 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001237 Postsynaptic IPR018293 Postsynaptic_CS IPR019568 Rapsyn_myristoylation/link_N IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR019734 TPR_repeat IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
Pfamⁱ	View protein in Pfam PF10579 Rapsyn_N, 1 hit PF13639 zf-RING_2, 1 hit
PRINTSⁱ	PR00217 POSTSYNAPTIC
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit SM00028 TPR, 7 hits
SUPFAMⁱ	SSF48452 SSF48452, 3 hits
PROSITEⁱ	View protein in PROSITE PS00405 43_KD_POSTSYNAPTIC, 1 hit PS50005 TPR, 5 hits PS50293 TPR_REGION, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAPSN_HUMAN
Accessionⁱ	Q13702Primary (citable) accession number: Q13702 Secondary accession number(s): Q8TDF3, Q9BTD9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	April 17, 2007
	Last modified:	September 12, 2018
	This is version 185 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q13702 (RAPSN_HUMAN)

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43 kDa receptor-associated protein of the synapse

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Plasma membrane

Cytoskeleton

Cytosol

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ