UniProtKB - Q13685 (AAMP_HUMAN)
Protein
Angio-associated migratory cell protein
Gene
AAMP
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.2 Publications
GO - Molecular functioni
- heparin binding Source: GO_Central
GO - Biological processi
- angiogenesis Source: UniProtKB
- cell differentiation Source: UniProtKB-KW
- positive regulation of endothelial cell migration Source: UniProtKB
- smooth muscle cell migration Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Angiogenesis, Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q13685 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-177929, Signaling by EGFR R-HSA-194138, Signaling by VEGF R-HSA-428930, Thromboxane signalling through TP receptor |
SignaLinki | Q13685 |
Names & Taxonomyi
Protein namesi | Recommended name: Angio-associated migratory cell protein |
Gene namesi | Name:AAMP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18, AAMP |
MIMi | 603488, gene |
neXtProti | NX_Q13685 |
VEuPathDBi | HostDB:ENSG00000127837.9 |
Subcellular locationi
Plasma membrane
Other locations
Cytoskeleton
- microtubule cytoskeleton Source: HPA
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- intercellular bridge Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell surface Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 14 |
OpenTargetsi | ENSG00000127837 |
PharmGKBi | PA24365 |
Miscellaneous databases
Pharosi | Q13685, Tbio |
Genetic variation databases
BioMutai | AAMP |
DMDMi | 62906874 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050832 | 1 – 434 | Angio-associated migratory cell proteinAdd BLAST | 434 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 20 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q13685 |
jPOSTi | Q13685 |
MassIVEi | Q13685 |
MaxQBi | Q13685 |
PaxDbi | Q13685 |
PeptideAtlasi | Q13685 |
PRIDEi | Q13685 |
ProteomicsDBi | 59660 |
PTM databases
iPTMneti | Q13685 |
PhosphoSitePlusi | Q13685 |
Expressioni
Tissue specificityi
Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.2 Publications
Gene expression databases
Bgeei | ENSG00000127837, Expressed in body of stomach and 237 other tissues |
ExpressionAtlasi | Q13685, baseline and differential |
Genevisiblei | Q13685, HS |
Organism-specific databases
HPAi | ENSG00000127837, Low tissue specificity |
Interactioni
Binary interactionsi
Q13685
With | #Exp. | IntAct |
---|---|---|
AEN - isoform 2 [Q8WTP8-2] | 4 | EBI-727274,EBI-12119298 |
Protein-protein interaction databases
BioGRIDi | 106532, 39 interactors |
IntActi | Q13685, 19 interactors |
MINTi | Q13685 |
STRINGi | 9606.ENSP00000248450 |
Miscellaneous databases
RNActi | Q13685, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 89 – 129 | WD 1Add BLAST | 41 | |
Repeati | 132 – 171 | WD 2Add BLAST | 40 | |
Repeati | 173 – 212 | WD 3Add BLAST | 40 | |
Repeati | 214 – 254 | WD 4Add BLAST | 41 | |
Repeati | 258 – 299 | WD 5Add BLAST | 42 | |
Repeati | 315 – 354 | WD 6Add BLAST | 40 | |
Repeati | 356 – 395 | WD 7Add BLAST | 40 | |
Repeati | 398 – 433 | WD 8Add BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 53 – 59 | Poly-Glu | 7 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0296, Eukaryota |
GeneTreei | ENSGT00940000153648 |
HOGENOMi | CLU_000288_57_9_1 |
InParanoidi | Q13685 |
OrthoDBi | 1025450at2759 |
PhylomeDBi | Q13685 |
TreeFami | TF314543 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 5 hits |
SMARTi | View protein in SMART SM00320, WD40, 8 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q13685-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV
60 70 80 90 100
DFEEEEEEEG NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD
110 120 130 140 150
PKTNTLAVTG GEDDKAFVWR LSDGELLFEC AGHKDSVTCA GFSHDSTLVA
160 170 180 190 200
TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM EWHPRAPVLL AGTADGNTWM
210 220 230 240 250
WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR IWDLKQGSPI
260 270 280 290 300
HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP
310 320 330 340 350
ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT
360 370 380 390 400
LRHQCQHQSG IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT
410 420 430
AEILDFALSK DASLVVTTSG DHKAKVFCVQ RPDR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JG97 | C9JG97_HUMAN | Angio-associated migratory cell pro... | AAMP | 415 | Annotation score: | ||
C9JEH3 | C9JEH3_HUMAN | Angio-associated migratory cell pro... | AAMP hCG_16292 | 435 | Annotation score: | ||
H7C0R2 | H7C0R2_HUMAN | Angio-associated migratory cell pro... | AAMP | 189 | Annotation score: | ||
C9JTS3 | C9JTS3_HUMAN | Angio-associated migratory cell pro... | AAMP | 200 | Annotation score: |
Sequence cautioni
The sequence AAA68889 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAG33036 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037061 | 250 | I → V. Corresponds to variant dbSNP:rs2305835Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M95627 mRNA Translation: AAA68889.1 Different initiation. CR456755 mRNA Translation: CAG33036.1 Different initiation. BC008809 mRNA Translation: AAH08809.2 BC020244 mRNA Translation: AAH20244.1 BC039866 mRNA Translation: AAH39866.2 |
CCDSi | CCDS33378.1 |
PIRi | I39383 |
RefSeqi | NP_001078.2, NM_001087.4 |
Genome annotation databases
Ensembli | ENST00000248450; ENSP00000248450; ENSG00000127837 |
GeneIDi | 14 |
KEGGi | hsa:14 |
UCSCi | uc002vhk.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M95627 mRNA Translation: AAA68889.1 Different initiation. CR456755 mRNA Translation: CAG33036.1 Different initiation. BC008809 mRNA Translation: AAH08809.2 BC020244 mRNA Translation: AAH20244.1 BC039866 mRNA Translation: AAH39866.2 |
CCDSi | CCDS33378.1 |
PIRi | I39383 |
RefSeqi | NP_001078.2, NM_001087.4 |
3D structure databases
SMRi | Q13685 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106532, 39 interactors |
IntActi | Q13685, 19 interactors |
MINTi | Q13685 |
STRINGi | 9606.ENSP00000248450 |
PTM databases
iPTMneti | Q13685 |
PhosphoSitePlusi | Q13685 |
Genetic variation databases
BioMutai | AAMP |
DMDMi | 62906874 |
Proteomic databases
EPDi | Q13685 |
jPOSTi | Q13685 |
MassIVEi | Q13685 |
MaxQBi | Q13685 |
PaxDbi | Q13685 |
PeptideAtlasi | Q13685 |
PRIDEi | Q13685 |
ProteomicsDBi | 59660 |
Protocols and materials databases
Antibodypediai | 34259, 165 antibodies |
Genome annotation databases
Ensembli | ENST00000248450; ENSP00000248450; ENSG00000127837 |
GeneIDi | 14 |
KEGGi | hsa:14 |
UCSCi | uc002vhk.4, human |
Organism-specific databases
CTDi | 14 |
DisGeNETi | 14 |
GeneCardsi | AAMP |
HGNCi | HGNC:18, AAMP |
HPAi | ENSG00000127837, Low tissue specificity |
MIMi | 603488, gene |
neXtProti | NX_Q13685 |
OpenTargetsi | ENSG00000127837 |
PharmGKBi | PA24365 |
VEuPathDBi | HostDB:ENSG00000127837.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0296, Eukaryota |
GeneTreei | ENSGT00940000153648 |
HOGENOMi | CLU_000288_57_9_1 |
InParanoidi | Q13685 |
OrthoDBi | 1025450at2759 |
PhylomeDBi | Q13685 |
TreeFami | TF314543 |
Enzyme and pathway databases
PathwayCommonsi | Q13685 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-177929, Signaling by EGFR R-HSA-194138, Signaling by VEGF R-HSA-428930, Thromboxane signalling through TP receptor |
SignaLinki | Q13685 |
Miscellaneous databases
BioGRID-ORCSi | 14, 679 hits in 880 CRISPR screens |
ChiTaRSi | AAMP, human |
GeneWikii | AAMP_(gene) |
GenomeRNAii | 14 |
Pharosi | Q13685, Tbio |
PROi | PR:Q13685 |
RNActi | Q13685, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000127837, Expressed in body of stomach and 237 other tissues |
ExpressionAtlasi | Q13685, baseline and differential |
Genevisiblei | Q13685, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 5 hits |
SMARTi | View protein in SMART SM00320, WD40, 8 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AAMP_HUMAN | |
Accessioni | Q13685Primary (citable) accession number: Q13685 Secondary accession number(s): Q8WUJ9, Q96H92 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | April 26, 2005 | |
Last modified: | February 10, 2021 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants