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Protein

Angio-associated migratory cell protein

Gene

AAMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.2 Publications

GO - Molecular functioni

  • heparin binding Source: GO_Central
  • unfolded protein binding Source: GO_Central

GO - Biological processi

  • angiogenesis Source: UniProtKB
  • cell differentiation Source: UniProtKB-KW
  • positive regulation of endothelial cell migration Source: UniProtKB
  • ribosomal large subunit biogenesis Source: GO_Central
  • smooth muscle cell migration Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

SignaLinkiQ13685

Names & Taxonomyi

Protein namesi
Recommended name:
Angio-associated migratory cell protein
Gene namesi
Name:AAMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000127837.9
HGNCiHGNC:18 AAMP
MIMi603488 gene
neXtProtiNX_Q13685

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi14
OpenTargetsiENSG00000127837
PharmGKBiPA24365

Polymorphism and mutation databases

BioMutaiAAMP
DMDMi62906874

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508321 – 434Angio-associated migratory cell proteinAdd BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13685
MaxQBiQ13685
PaxDbiQ13685
PeptideAtlasiQ13685
PRIDEiQ13685
ProteomicsDBi59660

PTM databases

iPTMnetiQ13685
PhosphoSitePlusiQ13685

Expressioni

Tissue specificityi

Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.2 Publications

Gene expression databases

BgeeiENSG00000127837 Expressed in 223 organ(s), highest expression level in body of stomach
CleanExiHS_AAMP
ExpressionAtlasiQ13685 baseline and differential
GenevisibleiQ13685 HS

Organism-specific databases

HPAiCAB017717
HPA031868

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106532, 33 interactors
IntActiQ13685, 10 interactors
MINTiQ13685
STRINGi9606.ENSP00000248450

Structurei

3D structure databases

ProteinModelPortaliQ13685
SMRiQ13685
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati89 – 129WD 1Add BLAST41
Repeati132 – 171WD 2Add BLAST40
Repeati173 – 212WD 3Add BLAST40
Repeati214 – 254WD 4Add BLAST41
Repeati258 – 299WD 5Add BLAST42
Repeati315 – 354WD 6Add BLAST40
Repeati356 – 395WD 7Add BLAST40
Repeati398 – 433WD 8Add BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 59Poly-Glu7

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0296 Eukaryota
ENOG410XR6A LUCA
GeneTreeiENSGT00870000136531
HOGENOMiHOG000261676
HOVERGENiHBG061307
InParanoidiQ13685
PhylomeDBiQ13685
TreeFamiTF314543

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q13685-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV
60 70 80 90 100
DFEEEEEEEG NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD
110 120 130 140 150
PKTNTLAVTG GEDDKAFVWR LSDGELLFEC AGHKDSVTCA GFSHDSTLVA
160 170 180 190 200
TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM EWHPRAPVLL AGTADGNTWM
210 220 230 240 250
WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR IWDLKQGSPI
260 270 280 290 300
HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP
310 320 330 340 350
ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT
360 370 380 390 400
LRHQCQHQSG IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT
410 420 430
AEILDFALSK DASLVVTTSG DHKAKVFCVQ RPDR
Length:434
Mass (Da):46,751
Last modified:April 26, 2005 - v2
Checksum:iA7B8314442EBAF15
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JG97C9JG97_HUMAN
Angio-associated migratory cell pro...
AAMP
415Annotation score:
C9JEH3C9JEH3_HUMAN
Angio-associated migratory cell pro...
AAMP hCG_16292
435Annotation score:
H7C0R2H7C0R2_HUMAN
Angio-associated migratory cell pro...
AAMP
189Annotation score:
C9JTS3C9JTS3_HUMAN
Angio-associated migratory cell pro...
AAMP
200Annotation score:

Sequence cautioni

The sequence AAA68889 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAG33036 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037061250I → V. Corresponds to variant dbSNP:rs2305835Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95627 mRNA Translation: AAA68889.1 Different initiation.
CR456755 mRNA Translation: CAG33036.1 Different initiation.
BC008809 mRNA Translation: AAH08809.2
BC020244 mRNA Translation: AAH20244.1
BC039866 mRNA Translation: AAH39866.2
CCDSiCCDS33378.1
PIRiI39383
RefSeqiNP_001078.2, NM_001087.4
UniGeneiHs.83347

Genome annotation databases

EnsembliENST00000248450; ENSP00000248450; ENSG00000127837
GeneIDi14
KEGGihsa:14
UCSCiuc002vhk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95627 mRNA Translation: AAA68889.1 Different initiation.
CR456755 mRNA Translation: CAG33036.1 Different initiation.
BC008809 mRNA Translation: AAH08809.2
BC020244 mRNA Translation: AAH20244.1
BC039866 mRNA Translation: AAH39866.2
CCDSiCCDS33378.1
PIRiI39383
RefSeqiNP_001078.2, NM_001087.4
UniGeneiHs.83347

3D structure databases

ProteinModelPortaliQ13685
SMRiQ13685
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106532, 33 interactors
IntActiQ13685, 10 interactors
MINTiQ13685
STRINGi9606.ENSP00000248450

PTM databases

iPTMnetiQ13685
PhosphoSitePlusiQ13685

Polymorphism and mutation databases

BioMutaiAAMP
DMDMi62906874

Proteomic databases

EPDiQ13685
MaxQBiQ13685
PaxDbiQ13685
PeptideAtlasiQ13685
PRIDEiQ13685
ProteomicsDBi59660

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248450; ENSP00000248450; ENSG00000127837
GeneIDi14
KEGGihsa:14
UCSCiuc002vhk.4 human

Organism-specific databases

CTDi14
DisGeNETi14
EuPathDBiHostDB:ENSG00000127837.9
GeneCardsiAAMP
HGNCiHGNC:18 AAMP
HPAiCAB017717
HPA031868
MIMi603488 gene
neXtProtiNX_Q13685
OpenTargetsiENSG00000127837
PharmGKBiPA24365
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0296 Eukaryota
ENOG410XR6A LUCA
GeneTreeiENSGT00870000136531
HOGENOMiHOG000261676
HOVERGENiHBG061307
InParanoidiQ13685
PhylomeDBiQ13685
TreeFamiTF314543

Enzyme and pathway databases

SignaLinkiQ13685

Miscellaneous databases

ChiTaRSiAAMP human
GeneWikiiAAMP_(gene)
GenomeRNAii14
PROiPR:Q13685
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127837 Expressed in 223 organ(s), highest expression level in body of stomach
CleanExiHS_AAMP
ExpressionAtlasiQ13685 baseline and differential
GenevisibleiQ13685 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAAMP_HUMAN
AccessioniPrimary (citable) accession number: Q13685
Secondary accession number(s): Q8WUJ9, Q96H92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 26, 2005
Last modified: September 12, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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