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Protein

Integrin alpha-7

Gene

ITGA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi372 – 380Sequence analysis9
Calcium bindingi434 – 442Sequence analysis9
Calcium bindingi492 – 500Sequence analysis9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell-matrix adhesion Source: ProtInc
  • endodermal cell differentiation Source: UniProtKB
  • extracellular matrix organization Source: Reactome
  • heterotypic cell-cell adhesion Source: UniProtKB
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • muscle organ development Source: ProtInc
  • regulation of cell shape Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion, Cell shape
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000157 Laminin interactions
R-HSA-3000178 ECM proteoglycans

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q13683

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13683

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-7
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGA7
ORF Names:UNQ406/PRO768
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000135424.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6143 ITGA7

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600536 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13683

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini34 – 1082ExtracellularSequence analysisAdd BLAST1049
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1083 – 1103HelicalSequence analysisAdd BLAST21
Topological domaini1104 – 1181CytoplasmicSequence analysisAdd BLAST78

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures.
See also OMIM:613204

Keywords - Diseasei

Congenital muscular dystrophy

Organism-specific databases

DisGeNET

More...
DisGeNETi
3679

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ITGA7

MalaCards human disease database

More...
MalaCardsi
ITGA7
MIMi613204 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000135424

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
2020 Congenital fiber-type disproportion myopathy
34520 Congenital muscular dystrophy with integrin alpha-7 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29943

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ITGA7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153592

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 332 PublicationsAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001626734 – 1181Integrin alpha-7Add BLAST1148
ChainiPRO_000001626834 – 955Integrin alpha-7 heavy chainSequence analysisAdd BLAST922
ChainiPRO_0000398833648 – 1181Integrin alpha-7 70 kDa formAdd BLAST534
ChainiPRO_0000016269959 – 1181Integrin alpha-7 light chainSequence analysisAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi94 ↔ 103By similarity
Disulfide bondi140 ↔ 163By similarity
Disulfide bondi184 ↔ 197By similarity
Disulfide bondi539 ↔ 546By similarity
Disulfide bondi552 ↔ 615By similarity
Disulfide bondi681 ↔ 687By similarity
Disulfide bondi781 ↔ 792By similarity
Glycosylationi786N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi939 ↔ 994Interchain (between heavy and light chains)By similarity
Glycosylationi989N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1001 ↔ 1006By similarity
Glycosylationi1025N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1045N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes.By similarity
A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei647 – 648Cleavage; by urokinase2

Keywords - PTMi

ADP-ribosylation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13683

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13683

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13683

PeptideAtlas

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PeptideAtlasi
Q13683

PRoteomics IDEntifications database

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PRIDEi
Q13683

ProteomicsDB human proteome resource

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ProteomicsDBi
59654
59655 [Q13683-10]
59656 [Q13683-13]
59657 [Q13683-3]
59658 [Q13683-7]
59659 [Q13683-9]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1409

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13683

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13683

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In renewing intestinal epithelium, expression of isoforms containing segment B correlates with the onset of enterocytic differentiation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000135424 Expressed in 212 organ(s), highest expression level in heart left ventricle

CleanEx database of gene expression profiles

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CleanExi
HS_ITGA7

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13683 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13683 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA008427

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-7 associates with beta-1. Interacts with COMP (By similarity). Interacts (via C-terminus intracellular tail region) with CIB1; the interaction is stabilized/increased in a calcium- and magnesium-dependent manner.By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109885, 39 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1804 Integrin alpha7-beta1 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13683

Database of interacting proteins

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DIPi
DIP-5981N

Protein interaction database and analysis system

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IntActi
Q13683, 1 interactor

Molecular INTeraction database

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MINTi
Q13683

STRING: functional protein association networks

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STRINGi
9606.ENSP00000452120

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13683

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati35 – 103FG-GAP 1PROSITE-ProRule annotationAdd BLAST69
Repeati110 – 175FG-GAP 2PROSITE-ProRule annotationAdd BLAST66
Repeati185 – 238FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati292 – 349FG-GAP 4PROSITE-ProRule annotationAdd BLAST58
Repeati350 – 411FG-GAP 5PROSITE-ProRule annotationAdd BLAST62
Repeati412 – 467FG-GAP 6PROSITE-ProRule annotationAdd BLAST56
Repeati471 – 530FG-GAP 7PROSITE-ProRule annotationAdd BLAST60
Repeati1157 – 116014
Repeati1165 – 116824
Repeati1173 – 117634

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1157 – 11763 X 4 AA repeats of D-X-H-PAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1107 – 1111GFFKR motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi953 – 958Poly-Arg6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IPBB Eukaryota
ENOG410XVGZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159891

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108011

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13683

KEGG Orthology (KO)

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KOi
K06583

Identification of Orthologs from Complete Genome Data

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OMAi
FFKRARY

Database of Orthologous Groups

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OrthoDBi
EOG091G012D

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13683

TreeFam database of animal gene trees

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TreeFami
TF105391

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.130, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF69179 SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. There is a combination of at least five alternatively spliced domains, three extracellular (X1, X2 and D) and two cytoplasmic (A and B). A third potential alternatively spliced cytoplasmic domain (C) does not appear to be expressed.

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha-7X1X2B (identifier: Q13683-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS
60 70 80 90 100
LFGFSVALHR QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE
110 120 130 140 150
TDCYRVDIDQ GADMQKESKE NQWLGVSVRS QGPGGKIVTC AHRYEARQRV
160 170 180 190 200
DQILETRDMI GRCFVLSQDL AIRDELDGGE WKFCEGRPQG HEQFGFCQQG
210 220 230 240 250
TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH LDDGPYEAGG
260 270 280 290 300
EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD
310 320 330 340 350
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV
360 370 380 390 400
PEVMLSGERL TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY
410 420 430 440 450
VYLNQGGHWA GISPLRLCGS PDSMFGISLA VLGDLNQDGF PDIAVGAPFD
460 470 480 490 500
GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI KSFGYSLSGS LDMDGNQYPD
510 520 530 540 550
LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA GGHSVCVDLR
560 570 580 590 600
VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ
610 620 630 640 650
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA
660 670 680 690 700
PGQGLPPVAP ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT
710 720 730 740 750
RVSDTEFQPL PMDVDGTTAL FALSGQPVIG LELMVTNLPS DPAQPQADGD
760 770 780 790 800
DAHEAQLLVM LPDSLHYSGV RALDPAEKPL CLSNENASHV ECELGNPMKR
810 820 830 840 850
GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS ARARVFIELP
860 870 880 890 900
LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL
910 920 930 940 950
GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV
960 970 980 990 1000
DSRDRRRREL EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN
1010 1020 1030 1040 1050
CVVFSCPLYS FDRAAVLHVW GRLWNSTFLE EYSAVKSLEV IVRANITVKS
1060 1070 1080 1090 1100
SIKNLMLRDA STVIPVMVYL DPMAVVAEGV PWWVILLAVL AGLLVLALLV
1110 1120 1130 1140 1150
LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT GTILRNNWGS
1160 1170 1180
PRREGPDAHP ILAADGHPEL GPDGHPGPGT A
Note: Gene prediction based on similarity to mouse ortholog.
Length:1,181
Mass (Da):128,948
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i341C0C72CDB8CA57
GO
Isoform Alpha-7X1B (identifier: Q13683-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-307: Missing.

Show »
Length:1,141
Mass (Da):124,690
Checksum:i156565867C8DC8FB
GO
Isoform Alpha-7X2B (identifier: Q13683-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-267: Missing.

Show »
Length:1,137
Mass (Da):124,307
Checksum:i43AB97240F469166
GO
Isoform Alpha-7X2DB (identifier: Q13683-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     702-776: Missing.

Show »
Length:1,106
Mass (Da):121,065
Checksum:iCF40297895F88BD2
GO
Isoform Alpha-7X1X2A (identifier: Q13683-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1106-1181: MGFFKRAKHP...PDGHPGPGTA → CGFFHRSSQS...PRPPCPSTMR

Show »
Length:1,162
Mass (Da):126,631
Checksum:iFC25805EDFC23D68
GO
Isoform 2 (identifier: Q13683-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-138: LEETDCYRVD...RSQGPGGKIV → MAPFATPMVQ...TRRSPFEGKE
     268-307: Missing.

Show »
Length:1,044
Mass (Da):114,545
Checksum:i84DF3FB44EE2A31D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNV4J3KNV4_HUMAN
Integrin alpha-7
ITGA7
1,131Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2C6G3V2C6_HUMAN
Integrin alpha-7
ITGA7
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2I4G3V2I4_HUMAN
Integrin alpha-7
ITGA7
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ26H0YJ26_HUMAN
Integrin alpha-7
ITGA7
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ98H0YJ98_HUMAN
Integrin alpha-7
ITGA7
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3L8G3V3L8_HUMAN
Integrin alpha-7
ITGA7
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJS5H0YJS5_HUMAN
Integrin alpha-7
ITGA7
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2Q6G3V2Q6_HUMAN
Integrin alpha-7
ITGA7
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti873A → T in AAC18968 (PubMed:9590299).Curated1
Sequence conflicti1005S → I in AAC18968 (PubMed:9590299).Curated1
Sequence conflicti1013R → H in AAH50280 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067015457I → V1 PublicationCorresponds to variant dbSNP:rs17857367Ensembl.1
Natural variantiVAR_067016506L → M1 PublicationCorresponds to variant dbSNP:rs17854599Ensembl.1
Natural variantiVAR_067017586R → H1 PublicationCorresponds to variant dbSNP:rs17854598Ensembl.1
Natural variantiVAR_014759695R → H6 PublicationsCorresponds to variant dbSNP:rs1800974Ensembl.1
Natural variantiVAR_067018696A → V1 PublicationCorresponds to variant dbSNP:rs17855684Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0404871 – 97Missing in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_04048898 – 138LEETD…GGKIV → MAPFATPMVQALTTTRIQRQ AEGFQCWRECGTRRSPFEGK E in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_002727224 – 267Missing in isoform Alpha-7X2B. 4 PublicationsAdd BLAST44
Alternative sequenceiVSP_002728268 – 307Missing in isoform Alpha-7X1B and isoform 2. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_042364702 – 776Missing in isoform Alpha-7X2DB. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_0027301106 – 1181MGFFK…GPGTA → CGFFHRSSQSSSFPTNYHRA CLAVQPSAMEVGGPGTVGWD SSNGRSTPRPPCPSTMR in isoform Alpha-7X1X2A. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF032108 mRNA Translation: AAC39708.1
AF052050 mRNA Translation: AAC18968.1
AF072132 mRNA Translation: AAC80458.1
AJ228836
, AJ228837, AJ228838, AJ228839, AJ228840, AJ228842, AJ228843, AJ228844, AJ228845, AJ228846, AJ228847, AJ228848, AJ228849, AJ228850, AJ228851, AJ228852, AJ228853, AJ228854, AJ228855, AJ228856, AJ228857, AJ228858, AJ228859, AJ228860, AJ228862 Genomic DNA Translation: CAB41534.1
AJ228836
, AJ228837, AJ228838, AJ228839, AJ228841, AJ228842, AJ228843, AJ228844, AJ228845, AJ228846, AJ228847, AJ228848, AJ228849, AJ228850, AJ228851, AJ228852, AJ228853, AJ228854, AJ228855, AJ228856, AJ228857, AJ228858, AJ228859, AJ228860, AJ228862 Genomic DNA Translation: CAB41535.1
AY358882 mRNA Translation: AAQ89241.1
AK304864 mRNA Translation: BAG65602.1
AC009779 Genomic DNA No translation available.
BC050280 mRNA Translation: AAH50280.1
X74295 mRNA Translation: CAA52348.1
AF034833 mRNA Translation: AAB87696.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44914.1 [Q13683-13]
CCDS55832.1 [Q13683-3]
CCDS8888.1 [Q13683-7]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5950

NCBI Reference Sequences

More...
RefSeqi
NP_001138468.1, NM_001144996.1 [Q13683-3]
NP_001138469.1, NM_001144997.1 [Q13683-13]
NP_002197.2, NM_002206.2 [Q13683-7]
XP_005268896.1, XM_005268839.1 [Q13683-1]
XP_005268898.1, XM_005268841.1 [Q13683-10]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.524484

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000257879; ENSP00000257879; ENSG00000135424 [Q13683-7]
ENST00000452168; ENSP00000393844; ENSG00000135424 [Q13683-13]
ENST00000553804; ENSP00000452120; ENSG00000135424 [Q13683-3]
ENST00000555728; ENSP00000452387; ENSG00000135424 [Q13683-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3679

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3679

UCSC genome browser

More...
UCSCi
uc001shg.4 human [Q13683-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032108 mRNA Translation: AAC39708.1
AF052050 mRNA Translation: AAC18968.1
AF072132 mRNA Translation: AAC80458.1
AJ228836
, AJ228837, AJ228838, AJ228839, AJ228840, AJ228842, AJ228843, AJ228844, AJ228845, AJ228846, AJ228847, AJ228848, AJ228849, AJ228850, AJ228851, AJ228852, AJ228853, AJ228854, AJ228855, AJ228856, AJ228857, AJ228858, AJ228859, AJ228860, AJ228862 Genomic DNA Translation: CAB41534.1
AJ228836
, AJ228837, AJ228838, AJ228839, AJ228841, AJ228842, AJ228843, AJ228844, AJ228845, AJ228846, AJ228847, AJ228848, AJ228849, AJ228850, AJ228851, AJ228852, AJ228853, AJ228854, AJ228855, AJ228856, AJ228857, AJ228858, AJ228859, AJ228860, AJ228862 Genomic DNA Translation: CAB41535.1
AY358882 mRNA Translation: AAQ89241.1
AK304864 mRNA Translation: BAG65602.1
AC009779 Genomic DNA No translation available.
BC050280 mRNA Translation: AAH50280.1
X74295 mRNA Translation: CAA52348.1
AF034833 mRNA Translation: AAB87696.1
CCDSiCCDS44914.1 [Q13683-13]
CCDS55832.1 [Q13683-3]
CCDS8888.1 [Q13683-7]
PIRiJC5950
RefSeqiNP_001138468.1, NM_001144996.1 [Q13683-3]
NP_001138469.1, NM_001144997.1 [Q13683-13]
NP_002197.2, NM_002206.2 [Q13683-7]
XP_005268896.1, XM_005268839.1 [Q13683-1]
XP_005268898.1, XM_005268841.1 [Q13683-10]
UniGeneiHs.524484

3D structure databases

ProteinModelPortaliQ13683
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109885, 39 interactors
ComplexPortaliCPX-1804 Integrin alpha7-beta1 complex
CORUMiQ13683
DIPiDIP-5981N
IntActiQ13683, 1 interactor
MINTiQ13683
STRINGi9606.ENSP00000452120

PTM databases

GlyConnecti1409
iPTMnetiQ13683
PhosphoSitePlusiQ13683

Polymorphism and mutation databases

BioMutaiITGA7
DMDMi308153592

Proteomic databases

EPDiQ13683
MaxQBiQ13683
PaxDbiQ13683
PeptideAtlasiQ13683
PRIDEiQ13683
ProteomicsDBi59654
59655 [Q13683-10]
59656 [Q13683-13]
59657 [Q13683-3]
59658 [Q13683-7]
59659 [Q13683-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257879; ENSP00000257879; ENSG00000135424 [Q13683-7]
ENST00000452168; ENSP00000393844; ENSG00000135424 [Q13683-13]
ENST00000553804; ENSP00000452120; ENSG00000135424 [Q13683-3]
ENST00000555728; ENSP00000452387; ENSG00000135424 [Q13683-1]
GeneIDi3679
KEGGihsa:3679
UCSCiuc001shg.4 human [Q13683-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3679
DisGeNETi3679
EuPathDBiHostDB:ENSG00000135424.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ITGA7
GeneReviewsiITGA7

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0010702
HIX0201958
HGNCiHGNC:6143 ITGA7
HPAiHPA008427
MalaCardsiITGA7
MIMi600536 gene
613204 phenotype
neXtProtiNX_Q13683
OpenTargetsiENSG00000135424
Orphaneti2020 Congenital fiber-type disproportion myopathy
34520 Congenital muscular dystrophy with integrin alpha-7 deficiency
PharmGKBiPA29943

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPBB Eukaryota
ENOG410XVGZ LUCA
GeneTreeiENSGT00940000159891
HOVERGENiHBG108011
InParanoidiQ13683
KOiK06583
OMAiFFKRARY
OrthoDBiEOG091G012D
PhylomeDBiQ13683
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-HSA-216083 Integrin cell surface interactions
R-HSA-3000157 Laminin interactions
R-HSA-3000178 ECM proteoglycans
SignaLinkiQ13683
SIGNORiQ13683

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ITGA7 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ITGA7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3679

Protein Ontology

More...
PROi
PR:Q13683

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135424 Expressed in 212 organ(s), highest expression level in heart left ventricle
CleanExiHS_ITGA7
ExpressionAtlasiQ13683 baseline and differential
GenevisibleiQ13683 HS

Family and domain databases

Gene3Di2.130.10.130, 2 hits
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITA7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13683
Secondary accession number(s): B4E3U0
, C9JMD3, C9JMZ6, O43197, Q86W93, Q9NY89, Q9UET0, Q9UEV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 5, 2010
Last modified: December 5, 2018
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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