ITGA7

Functionⁱ

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.By similarity3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Calcium bindingⁱ	372 – 380	Sequence analysis	9
Calcium bindingⁱ	434 – 442	Sequence analysis	9
Calcium bindingⁱ	492 – 500	Sequence analysis	9

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Integrin, Receptor
Biological process	Cell adhesion, Cell shape
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

PathwayCommonsⁱ	Q13683
Reactomeⁱ	R-HSA-216083, Integrin cell surface interactions R-HSA-3000157, Laminin interactions R-HSA-3000178, ECM proteoglycans
SignaLinkⁱ	Q13683
SIGNORⁱ	Q13683

Protein family/group databases

TCDBⁱ	8.A.54.1.5, the integrin (integrin) family

TCDBⁱ

8.A.54.1.5, the integrin (integrin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Integrin alpha-7 Cleaved into the following 3 chains: Integrin alpha-7 heavy chain Integrin alpha-7 light chain Integrin alpha-7 70 kDa form
Gene namesⁱ	Name:ITGA7 ORF Names:UNQ406/PRO768
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6143, ITGA7
MIMⁱ	600536, gene
neXtProtⁱ	NX_Q13683
VEuPathDBⁱ	HostDB:ENSG00000135424.15

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	34 – 1082	ExtracellularSequence analysisAdd BLAST	1049
Transmembraneⁱ	1083 – 1103	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1104 – 1181	CytoplasmicSequence analysisAdd BLAST	78

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI)1 Publication

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures.

Related information in OMIM

Keywords - Diseaseⁱ

Congenital muscular dystrophy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3679
MalaCards human disease database More...MalaCardsⁱ	ITGA7
MIMⁱ	613204, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000135424
Orphanetⁱ	2020, Congenital fiber-type disproportion myopathy 34520, Congenital muscular dystrophy with integrin alpha-7 deficiency
PharmGKBⁱ	PA29943

Miscellaneous databases

Pharosⁱ	Q13683, Tbio

Pharosⁱ

Q13683, Tbio

Genetic variation databases

BioMutaⁱ	ITGA7
DMDMⁱ	308153592

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 33	2 PublicationsAdd BLAST	33
ChainⁱPRO_0000016267	34 – 1181	Integrin alpha-7Add BLAST	1148
ChainⁱPRO_0000016268	34 – 955	Integrin alpha-7 heavy chainSequence analysisAdd BLAST	922
ChainⁱPRO_0000398833	648 – 1181	Integrin alpha-7 70 kDa formAdd BLAST	534
ChainⁱPRO_0000016269	959 – 1181	Integrin alpha-7 light chainSequence analysisAdd BLAST	223

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	86	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	94 ↔ 103	By similarity
Disulfide bondⁱ	140 ↔ 163	By similarity
Disulfide bondⁱ	184 ↔ 197	By similarity
Disulfide bondⁱ	539 ↔ 546	By similarity
Disulfide bondⁱ	552 ↔ 615	By similarity
Disulfide bondⁱ	681 ↔ 687	By similarity
Disulfide bondⁱ	781 ↔ 792	By similarity
Glycosylationⁱ	786	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	939 ↔ 994	Interchain (between heavy and light chains)By similarity
Glycosylationⁱ	989	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1001 ↔ 1006	By similarity
Glycosylationⁱ	1025	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	1045	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes.By similarity

A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	647 – 648	Cleavage; by urokinase		2

Keywords - PTMⁱ

ADP-ribosylation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q13683
jPOSTⁱ	Q13683
MassIVEⁱ	Q13683
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13683
PaxDbⁱ	Q13683
PeptideAtlas More...PeptideAtlasⁱ	Q13683
PRIDEⁱ	Q13683
ProteomicsDBⁱ	59654 [Q13683-1] 59655 [Q13683-10] 59656 [Q13683-13] 59657 [Q13683-3] 59658 [Q13683-7] 59659 [Q13683-9]

PTM databases

GlyGenⁱ	Q13683, 5 sites
iPTMnetⁱ	Q13683
PhosphoSitePlusⁱ	Q13683

Expressionⁱ

Tissue specificityⁱ

Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle.1 Publication

Developmental stageⁱ

In renewing intestinal epithelium, expression of isoforms containing segment B correlates with the onset of enterocytic differentiation.

Gene expression databases

Bgeeⁱ	ENSG00000135424, Expressed in heart left ventricle and 225 other tissues
ExpressionAtlasⁱ	Q13683, baseline and differential
Genevisibleⁱ	Q13683, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000135424, Tissue enhanced (heart muscle, skeletal muscle)

HPAⁱ

ENSG00000135424, Tissue enhanced (heart muscle, skeletal muscle)

Interactionⁱ

Subunit structureⁱ

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-7 associates with beta-1.

Interacts with COMP (By similarity).

Interacts (via C-terminus intracellular tail region) with CIB1; the interaction is stabilized/increased in a calcium- and magnesium-dependent manner.

By similarity1 Publication

Protein-protein interaction databases

BioGRIDⁱ	109885, 40 interactors
ComplexPortalⁱ	CPX-1804, Integrin alpha7-beta1 complex
CORUMⁱ	Q13683
Database of interacting proteins More...DIPⁱ	DIP-5981N
IntActⁱ	Q13683, 24 interactors
Molecular INTeraction database More...MINTⁱ	Q13683
STRINGⁱ	9606.ENSP00000452120

Miscellaneous databases

RNActⁱ	Q13683, protein

RNActⁱ

Q13683, protein

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	35 – 103	FG-GAP 1PROSITE-ProRule annotationAdd BLAST	69
Repeatⁱ	110 – 175	FG-GAP 2PROSITE-ProRule annotationAdd BLAST	66
Repeatⁱ	185 – 238	FG-GAP 3PROSITE-ProRule annotationAdd BLAST	54
Repeatⁱ	292 – 349	FG-GAP 4PROSITE-ProRule annotationAdd BLAST	58
Repeatⁱ	350 – 411	FG-GAP 5PROSITE-ProRule annotationAdd BLAST	62
Repeatⁱ	412 – 467	FG-GAP 6PROSITE-ProRule annotationAdd BLAST	56
Repeatⁱ	471 – 530	FG-GAP 7PROSITE-ProRule annotationAdd BLAST	60
Repeatⁱ	1157 – 1160	1	4
Repeatⁱ	1165 – 1168	2	4
Repeatⁱ	1173 – 1176	3	4

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1157 – 1176	3 X 4 AA repeats of D-X-H-PAdd BLAST		20

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	1107 – 1111	GFFKR motif		5

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	953 – 958	Poly-Arg		6

Sequence similaritiesⁱ

Belongs to the integrin alpha chain family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3637, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159891
InParanoidⁱ	Q13683
OMAⁱ	HIDFEGT
Database of Orthologous Groups More...OrthoDBⁱ	743479at2759
PhylomeDBⁱ	Q13683
TreeFamⁱ	TF105391

Family and domain databases

Gene3Dⁱ	2.130.10.130, 2 hits
InterProⁱ	View protein in InterPro IPR013517, FG-GAP IPR013519, Int_alpha_beta-p IPR000413, Integrin_alpha IPR013649, Integrin_alpha-2 IPR018184, Integrin_alpha_C_CS IPR028994, Integrin_alpha_N IPR032695, Integrin_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01839, FG-GAP, 2 hits PF08441, Integrin_alpha2, 1 hit
PRINTSⁱ	PR01185, INTEGRINA
SMARTⁱ	View protein in SMART SM00191, Int_alpha, 5 hits
SUPFAMⁱ	SSF69179, SSF69179, 3 hits
PROSITEⁱ	View protein in PROSITE PS51470, FG_GAP, 7 hits PS00242, INTEGRIN_ALPHA, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist. There is a combination of at least five alternatively spliced domains, three extracellular (X1, X2 and D) and two cytoplasmic (A and B). A third potential alternatively spliced cytoplasmic domain (C) does not appear to be expressed.

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform Alpha-7X1X2B (identifier: Q13683-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS 
        60         70         80         90        100
LFGFSVALHR QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE 
       110        120        130        140        150
TDCYRVDIDQ GADMQKESKE NQWLGVSVRS QGPGGKIVTC AHRYEARQRV 
       160        170        180        190        200
DQILETRDMI GRCFVLSQDL AIRDELDGGE WKFCEGRPQG HEQFGFCQQG 
       210        220        230        240        250
TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH LDDGPYEAGG 
       260        270        280        290        300
EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD 
       310        320        330        340        350
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV 
       360        370        380        390        400
PEVMLSGERL TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY 
       410        420        430        440        450
VYLNQGGHWA GISPLRLCGS PDSMFGISLA VLGDLNQDGF PDIAVGAPFD 
       460        470        480        490        500
GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI KSFGYSLSGS LDMDGNQYPD 
       510        520        530        540        550
LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA GGHSVCVDLR 
       560        570        580        590        600
VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ 
       610        620        630        640        650
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA 
       660        670        680        690        700
PGQGLPPVAP ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT 
       710        720        730        740        750
RVSDTEFQPL PMDVDGTTAL FALSGQPVIG LELMVTNLPS DPAQPQADGD 
       760        770        780        790        800
DAHEAQLLVM LPDSLHYSGV RALDPAEKPL CLSNENASHV ECELGNPMKR 
       810        820        830        840        850
GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS ARARVFIELP 
       860        870        880        890        900
LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL 
       910        920        930        940        950
GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV 
       960        970        980        990       1000
DSRDRRRREL EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN 
      1010       1020       1030       1040       1050
CVVFSCPLYS FDRAAVLHVW GRLWNSTFLE EYSAVKSLEV IVRANITVKS 
      1060       1070       1080       1090       1100
SIKNLMLRDA STVIPVMVYL DPMAVVAEGV PWWVILLAVL AGLLVLALLV 
      1110       1120       1130       1140       1150
LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT GTILRNNWGS 
      1160       1170       1180 
PRREGPDAHP ILAADGHPEL GPDGHPGPGT A

Length:1,181

Mass (Da):128,948

Last modified:October 5, 2010 - v3

Checksum:ⁱ341C0C72CDB8CA57

GO

Isoform Alpha-7X1B (identifier: Q13683-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
268-307: Missing.

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        10         20         30         40         50
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS 
        60         70         80         90        100
LFGFSVALHR QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE 
       110        120        130        140        150
TDCYRVDIDQ GADMQKESKE NQWLGVSVRS QGPGGKIVTC AHRYEARQRV 
       160        170        180        190        200
DQILETRDMI GRCFVLSQDL AIRDELDGGE WKFCEGRPQG HEQFGFCQQG 
       210        220        230        240        250
TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH LDDGPYEAGG 
       260        270        280        290        300
EKEQDPRLIP VPANSYFGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI 
       310        320        330        340        350
LRKDSASRLV PEVMLSGERL TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE 
       360        370        380        390        400
RQEELGGAVY VYLNQGGHWA GISPLRLCGS PDSMFGISLA VLGDLNQDGF 
       410        420        430        440        450
PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI KSFGYSLSGS 
       460        470        480        490        500
LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA 
       510        520        530        540        550
GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL 
       560        570        580        590        600
SRNLEEPKHQ ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS 
       610        620        630        640        650
LQTPRLRRQA PGQGLPPVAP ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN 
       660        670        680        690        700
LQLVRARFCT RVSDTEFQPL PMDVDGTTAL FALSGQPVIG LELMVTNLPS 
       710        720        730        740        750
DPAQPQADGD DAHEAQLLVM LPDSLHYSGV RALDPAEKPL CLSNENASHV 
       760        770        780        790        800
ECELGNPMKR GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS 
       810        820        830        840        850
ARARVFIELP LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV 
       860        870        880        890        900
SNQGQSLRTL GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS 
       910        920        930        940        950
PRPNILHLDV DSRDRRRREL EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI 
       960        970        980        990       1000
TLDCARGTAN CVVFSCPLYS FDRAAVLHVW GRLWNSTFLE EYSAVKSLEV 
      1010       1020       1030       1040       1050
IVRANITVKS SIKNLMLRDA STVIPVMVYL DPMAVVAEGV PWWVILLAVL 
      1060       1070       1080       1090       1100
AGLLVLALLV LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT 
      1110       1120       1130       1140 
GTILRNNWGS PRREGPDAHP ILAADGHPEL GPDGHPGPGT A

Show »

Length:1,141

Mass (Da):124,690

Checksum:ⁱ156565867C8DC8FB

GO

Isoform Alpha-7X2B (identifier: Q13683-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
224-267: Missing.

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        10         20         30         40         50
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS 
        60         70         80         90        100
LFGFSVALHR QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE 
       110        120        130        140        150
TDCYRVDIDQ GADMQKESKE NQWLGVSVRS QGPGGKIVTC AHRYEARQRV 
       160        170        180        190        200
DQILETRDMI GRCFVLSQDL AIRDELDGGE WKFCEGRPQG HEQFGFCQQG 
       210        220        230        240        250
TAAAFSPDSH YLLFGAPGTY NWKGLLFVTN IDSSDPDQLV YKTLDPADRL 
       260        270        280        290        300
PGPAGDLALN SYLGFSIDSG KGLVRAEELS FVAGAPRANH KGAVVILRKD 
       310        320        330        340        350
SASRLVPEVM LSGERLTSGF GYSLAVADLN SDGWPDLIVG APYFFERQEE 
       360        370        380        390        400
LGGAVYVYLN QGGHWAGISP LRLCGSPDSM FGISLAVLGD LNQDGFPDIA 
       410        420        430        440        450
VGAPFDGDGK VFIYHGSSLG VVAKPSQVLE GEAVGIKSFG YSLSGSLDMD 
       460        470        480        490        500
GNQYPDLLVG SLADTAVLFR ARPILHVSHE VSIAPRSIDL EQPNCAGGHS 
       510        520        530        540        550
VCVDLRVCFS YIAVPSSYSP TVALDYVLDA DTDRRLRGQV PRVTFLSRNL 
       560        570        580        590        600
EEPKHQASGT VWLKHQHDRV CGDAMFQLQE NVKDKLRAIV VTLSYSLQTP 
       610        620        630        640        650
RLRRQAPGQG LPPVAPILNA HQPSTQRAEI HFLKQGCGED KICQSNLQLV 
       660        670        680        690        700
RARFCTRVSD TEFQPLPMDV DGTTALFALS GQPVIGLELM VTNLPSDPAQ 
       710        720        730        740        750
PQADGDDAHE AQLLVMLPDS LHYSGVRALD PAEKPLCLSN ENASHVECEL 
       760        770        780        790        800
GNPMKRGAQV TFYLILSTSG ISIETTELEV ELLLATISEQ ELHPVSARAR 
       810        820        830        840        850
VFIELPLSIA GMAIPQQLFF SGVVRGERAM QSERDVGSKV KYEVTVSNQG 
       860        870        880        890        900
QSLRTLGSAF LNIMWPHEIA NGKWLLYPMQ VELEGGQGPG QKGLCSPRPN 
       910        920        930        940        950
ILHLDVDSRD RRRRELEPPE QQEPGERQEP SMSWWPVSSA EKKKNITLDC 
       960        970        980        990       1000
ARGTANCVVF SCPLYSFDRA AVLHVWGRLW NSTFLEEYSA VKSLEVIVRA 
      1010       1020       1030       1040       1050
NITVKSSIKN LMLRDASTVI PVMVYLDPMA VVAEGVPWWV ILLAVLAGLL 
      1060       1070       1080       1090       1100
VLALLVLLLW KMGFFKRAKH PEATVPQYHA VKIPREDRQQ FKEEKTGTIL 
      1110       1120       1130 
RNNWGSPRRE GPDAHPILAA DGHPELGPDG HPGPGTA

Show »

Length:1,137

Mass (Da):124,307

Checksum:ⁱ43AB97240F469166

GO

Isoform Alpha-7X2DB (identifier: Q13683-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
702-776: Missing.

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        10         20         30         40         50
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS 
        60         70         80         90        100
LFGFSVALHR QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE 
       110        120        130        140        150
TDCYRVDIDQ GADMQKESKE NQWLGVSVRS QGPGGKIVTC AHRYEARQRV 
       160        170        180        190        200
DQILETRDMI GRCFVLSQDL AIRDELDGGE WKFCEGRPQG HEQFGFCQQG 
       210        220        230        240        250
TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH LDDGPYEAGG 
       260        270        280        290        300
EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD 
       310        320        330        340        350
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV 
       360        370        380        390        400
PEVMLSGERL TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY 
       410        420        430        440        450
VYLNQGGHWA GISPLRLCGS PDSMFGISLA VLGDLNQDGF PDIAVGAPFD 
       460        470        480        490        500
GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI KSFGYSLSGS LDMDGNQYPD 
       510        520        530        540        550
LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA GGHSVCVDLR 
       560        570        580        590        600
VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ 
       610        620        630        640        650
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA 
       660        670        680        690        700
PGQGLPPVAP ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT 
       710        720        730        740        750
REKPLCLSNE NASHVECELG NPMKRGAQVT FYLILSTSGI SIETTELEVE 
       760        770        780        790        800
LLLATISEQE LHPVSARARV FIELPLSIAG MAIPQQLFFS GVVRGERAMQ 
       810        820        830        840        850
SERDVGSKVK YEVTVSNQGQ SLRTLGSAFL NIMWPHEIAN GKWLLYPMQV 
       860        870        880        890        900
ELEGGQGPGQ KGLCSPRPNI LHLDVDSRDR RRRELEPPEQ QEPGERQEPS 
       910        920        930        940        950
MSWWPVSSAE KKKNITLDCA RGTANCVVFS CPLYSFDRAA VLHVWGRLWN 
       960        970        980        990       1000
STFLEEYSAV KSLEVIVRAN ITVKSSIKNL MLRDASTVIP VMVYLDPMAV 
      1010       1020       1030       1040       1050
VAEGVPWWVI LLAVLAGLLV LALLVLLLWK MGFFKRAKHP EATVPQYHAV 
      1060       1070       1080       1090       1100
KIPREDRQQF KEEKTGTILR NNWGSPRREG PDAHPILAAD GHPELGPDGH 

PGPGTA

Show »

Length:1,106

Mass (Da):121,065

Checksum:ⁱCF40297895F88BD2

GO

Isoform Alpha-7X1X2A (identifier: Q13683-10) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1106-1181: MGFFKRAKHP...PDGHPGPGTA → CGFFHRSSQS...PRPPCPSTMR

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        10         20         30         40         50
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS 
        60         70         80         90        100
LFGFSVALHR QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE 
       110        120        130        140        150
TDCYRVDIDQ GADMQKESKE NQWLGVSVRS QGPGGKIVTC AHRYEARQRV 
       160        170        180        190        200
DQILETRDMI GRCFVLSQDL AIRDELDGGE WKFCEGRPQG HEQFGFCQQG 
       210        220        230        240        250
TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH LDDGPYEAGG 
       260        270        280        290        300
EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD 
       310        320        330        340        350
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV 
       360        370        380        390        400
PEVMLSGERL TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY 
       410        420        430        440        450
VYLNQGGHWA GISPLRLCGS PDSMFGISLA VLGDLNQDGF PDIAVGAPFD 
       460        470        480        490        500
GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI KSFGYSLSGS LDMDGNQYPD 
       510        520        530        540        550
LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA GGHSVCVDLR 
       560        570        580        590        600
VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ 
       610        620        630        640        650
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA 
       660        670        680        690        700
PGQGLPPVAP ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT 
       710        720        730        740        750
RVSDTEFQPL PMDVDGTTAL FALSGQPVIG LELMVTNLPS DPAQPQADGD 
       760        770        780        790        800
DAHEAQLLVM LPDSLHYSGV RALDPAEKPL CLSNENASHV ECELGNPMKR 
       810        820        830        840        850
GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS ARARVFIELP 
       860        870        880        890        900
LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL 
       910        920        930        940        950
GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV 
       960        970        980        990       1000
DSRDRRRREL EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN 
      1010       1020       1030       1040       1050
CVVFSCPLYS FDRAAVLHVW GRLWNSTFLE EYSAVKSLEV IVRANITVKS 
      1060       1070       1080       1090       1100
SIKNLMLRDA STVIPVMVYL DPMAVVAEGV PWWVILLAVL AGLLVLALLV 
      1110       1120       1130       1140       1150
LLLWKCGFFH RSSQSSSFPT NYHRACLAVQ PSAMEVGGPG TVGWDSSNGR 
      1160 
STPRPPCPST MR

Show »

Length:1,162

Mass (Da):126,631

Checksum:ⁱFC25805EDFC23D68

GO

Isoform 2 (identifier: Q13683-13) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-138: LEETDCYRVD...RSQGPGGKIV → MAPFATPMVQ...TRRSPFEGKE
     268-307: Missing.

« Hide

        10         20         30         40         50
MAPFATPMVQ ALTTTRIQRQ AEGFQCWREC GTRRSPFEGK ETCAHRYEAR 
        60         70         80         90        100
QRVDQILETR DMIGRCFVLS QDLAIRDELD GGEWKFCEGR PQGHEQFGFC 
       110        120        130        140        150
QQGTAAAFSP DSHYLLFGAP GTYNWKGTAR VELCAQGSAD LAHLDDGPYE 
       160        170        180        190        200
AGGEKEQDPR LIPVPANSYF GFSIDSGKGL VRAEELSFVA GAPRANHKGA 
       210        220        230        240        250
VVILRKDSAS RLVPEVMLSG ERLTSGFGYS LAVADLNSDG WPDLIVGAPY 
       260        270        280        290        300
FFERQEELGG AVYVYLNQGG HWAGISPLRL CGSPDSMFGI SLAVLGDLNQ 
       310        320        330        340        350
DGFPDIAVGA PFDGDGKVFI YHGSSLGVVA KPSQVLEGEA VGIKSFGYSL 
       360        370        380        390        400
SGSLDMDGNQ YPDLLVGSLA DTAVLFRARP ILHVSHEVSI APRSIDLEQP 
       410        420        430        440        450
NCAGGHSVCV DLRVCFSYIA VPSSYSPTVA LDYVLDADTD RRLRGQVPRV 
       460        470        480        490        500
TFLSRNLEEP KHQASGTVWL KHQHDRVCGD AMFQLQENVK DKLRAIVVTL 
       510        520        530        540        550
SYSLQTPRLR RQAPGQGLPP VAPILNAHQP STQRAEIHFL KQGCGEDKIC 
       560        570        580        590        600
QSNLQLVRAR FCTRVSDTEF QPLPMDVDGT TALFALSGQP VIGLELMVTN 
       610        620        630        640        650
LPSDPAQPQA DGDDAHEAQL LVMLPDSLHY SGVRALDPAE KPLCLSNENA 
       660        670        680        690        700
SHVECELGNP MKRGAQVTFY LILSTSGISI ETTELEVELL LATISEQELH 
       710        720        730        740        750
PVSARARVFI ELPLSIAGMA IPQQLFFSGV VRGERAMQSE RDVGSKVKYE 
       760        770        780        790        800
VTVSNQGQSL RTLGSAFLNI MWPHEIANGK WLLYPMQVEL EGGQGPGQKG 
       810        820        830        840        850
LCSPRPNILH LDVDSRDRRR RELEPPEQQE PGERQEPSMS WWPVSSAEKK 
       860        870        880        890        900
KNITLDCARG TANCVVFSCP LYSFDRAAVL HVWGRLWNST FLEEYSAVKS 
       910        920        930        940        950
LEVIVRANIT VKSSIKNLML RDASTVIPVM VYLDPMAVVA EGVPWWVILL 
       960        970        980        990       1000
AVLAGLLVLA LLVLLLWKMG FFKRAKHPEA TVPQYHAVKI PREDRQQFKE 
      1010       1020       1030       1040 
EKTGTILRNN WGSPRREGPD AHPILAADGH PELGPDGHPG PGTA

Show »

Length:1,044

Mass (Da):114,545

Checksum:ⁱ84DF3FB44EE2A31D

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KNV4	J3KNV4_HUMAN	Integrin alpha-7 Integrin alpha-7	ITGA7	1,131	Annotation score:
H0YJ98	H0YJ98_HUMAN	Integrin alpha-7 Integrin alpha-7	ITGA7	148	Annotation score:
G3V2C6	G3V2C6_HUMAN	Integrin alpha-7 Integrin alpha-7	ITGA7	153	Annotation score:
H0YJ26	H0YJ26_HUMAN	Integrin alpha-7 Integrin alpha-7	ITGA7	109	Annotation score:
G3V2I4	G3V2I4_HUMAN	Integrin alpha-7 Integrin alpha-7	ITGA7	98	Annotation score:
G3V3L8	G3V3L8_HUMAN	Integrin alpha-7 Integrin alpha-7	ITGA7	55	Annotation score:
H0YJS5	H0YJS5_HUMAN	Integrin alpha-7 Integrin alpha-7	ITGA7	35	Annotation score:
G3V2Q6	G3V2Q6_HUMAN	Integrin alpha-7 Integrin alpha-7	ITGA7	48	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	873	A → T in AAC18968 (PubMed:9590299).Curated	1
Sequence conflictⁱ	1005	S → I in AAC18968 (PubMed:9590299).Curated	1
Sequence conflictⁱ	1013	R → H in AAH50280 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_067015	457	I → V1 PublicationCorresponds to variant dbSNP:rs17857367Ensembl.	1
Natural variantⁱVAR_067016	506	L → M1 PublicationCorresponds to variant dbSNP:rs17854599Ensembl.	1
Natural variantⁱVAR_067017	586	R → H1 PublicationCorresponds to variant dbSNP:rs17854598Ensembl.	1
Natural variantⁱVAR_014759	695	R → H6 PublicationsCorresponds to variant dbSNP:rs1800974Ensembl.	1
Natural variantⁱVAR_067018	696	A → V1 PublicationCorresponds to variant dbSNP:rs17855684Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_040487	1 – 97	Missing in isoform 2. 1 PublicationAdd BLAST	97
Alternative sequenceⁱVSP_040488	98 – 138	LEETD…GGKIV → MAPFATPMVQALTTTRIQRQ AEGFQCWRECGTRRSPFEGK E in isoform 2. 1 PublicationAdd BLAST	41
Alternative sequenceⁱVSP_002727	224 – 267	Missing in isoform Alpha-7X2B. 4 PublicationsAdd BLAST	44
Alternative sequenceⁱVSP_002728	268 – 307	Missing in isoform Alpha-7X1B and isoform 2. 2 PublicationsAdd BLAST	40
Alternative sequenceⁱVSP_042364	702 – 776	Missing in isoform Alpha-7X2DB. 1 PublicationAdd BLAST	75
Alternative sequenceⁱVSP_002730	1106 – 1181	MGFFK…GPGTA → CGFFHRSSQSSSFPTNYHRA CLAVQPSAMEVGGPGTVGWD SSNGRSTPRPPCPSTMR in isoform Alpha-7X1X2A. 1 PublicationAdd BLAST	76

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF032108 mRNA Translation: AAC39708.1 AF052050 mRNA Translation: AAC18968.1 AF072132 mRNA Translation: AAC80458.1 AJ228836 AJ228862 Genomic DNA Translation: CAB41534.1 AJ228836 AJ228862 Genomic DNA Translation: CAB41535.1 AY358882 mRNA Translation: AAQ89241.1 AK304864 mRNA Translation: BAG65602.1 AC009779 Genomic DNA No translation available. BC050280 mRNA Translation: AAH50280.1 X74295 mRNA Translation: CAA52348.1 AF034833 mRNA Translation: AAB87696.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44914.1 [Q13683-13] CCDS55832.1 [Q13683-3] CCDS8888.1 [Q13683-7]
PIRⁱ	JC5950
NCBI Reference Sequences More...RefSeqⁱ	NP_001138468.1, NM_001144996.1 [Q13683-3] NP_001138469.1, NM_001144997.1 [Q13683-13] NP_002197.2, NM_002206.2 [Q13683-7] XP_005268896.1, XM_005268839.1 [Q13683-1] XP_005268898.1, XM_005268841.1 [Q13683-10]

Genome annotation databases

Ensemblⁱ	ENST00000257879; ENSP00000257879; ENSG00000135424 [Q13683-7] ENST00000452168; ENSP00000393844; ENSG00000135424 [Q13683-13] ENST00000553804; ENSP00000452120; ENSG00000135424 [Q13683-3] ENST00000555728; ENSP00000452387; ENSG00000135424 [Q13683-1]
GeneIDⁱ	3679
KEGGⁱ	hsa:3679
UCSC genome browser More...UCSCⁱ	uc001shg.4, human [Q13683-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13683-7	ITGA7 variant protein (Fragment)		HUMAN		1200	UniRef100_Q13683-7
ITGA7 isoform 14 (Fragment)		PANTR		153
Integrin alpha-7 isoform 2 (Fragment)		MACMU		215
Integrin alpha-7 (Fragment)		HUMAN		153
+3
Q13683-10	Integrin alpha-7 (Fragment)		HUMAN		148	UniRef100_Q13683-10

Protein	Similar proteins		Species	Score	Length	Source
Q13683	Integrin subunit alpha 7		OTOGA		1182	UniRef90_Q13683
ITGA7 isoform 14		PONAB		1181
Integrin_alpha2 domain-containing protein		MANLE		1181
Integrin_alpha2 domain-containing protein		COLAP		1181
Integrin_alpha2 domain-containing protein		PANPA		1181
+99
Q13683-3	Integrin subunit alpha 7		HORSE		1184	UniRef90_Q13683-3
Integrin_alpha2 domain-containing protein		PROCO		1181
integrin alpha-7 isoform X1		VULVU		1181
integrin alpha-7 isoform X2		PTEVA		1181
Integrin subunit alpha 7		ROUAE		1181
+236

Protein	Similar proteins		Species	Score	Length	Source
Q13683	Isoform Alpha-6X2A of Integrin alpha-6		HUMAN		1068	UniRef50_P23229-4
Integrin alpha-7		RAT		1135
Integrin alpha-7		MOUSE		1179
Integrin subunit alpha 6		MOLMO		1131
Integrin subunit alpha 6		PONAB		1113
+1079

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF032108 mRNA Translation: AAC39708.1 AF052050 mRNA Translation: AAC18968.1 AF072132 mRNA Translation: AAC80458.1 AJ228836 AJ228862 Genomic DNA Translation: CAB41534.1 AJ228836 AJ228862 Genomic DNA Translation: CAB41535.1 AY358882 mRNA Translation: AAQ89241.1 AK304864 mRNA Translation: BAG65602.1 AC009779 Genomic DNA No translation available. BC050280 mRNA Translation: AAH50280.1 X74295 mRNA Translation: CAA52348.1 AF034833 mRNA Translation: AAB87696.1
CCDSⁱ	CCDS44914.1 [Q13683-13] CCDS55832.1 [Q13683-3] CCDS8888.1 [Q13683-7]
PIRⁱ	JC5950
RefSeqⁱ	NP_001138468.1, NM_001144996.1 [Q13683-3] NP_001138469.1, NM_001144997.1 [Q13683-13] NP_002197.2, NM_002206.2 [Q13683-7] XP_005268896.1, XM_005268839.1 [Q13683-1] XP_005268898.1, XM_005268841.1 [Q13683-10]

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

BioGRIDⁱ	109885, 40 interactors
ComplexPortalⁱ	CPX-1804, Integrin alpha7-beta1 complex
CORUMⁱ	Q13683
DIPⁱ	DIP-5981N
IntActⁱ	Q13683, 24 interactors
MINTⁱ	Q13683
STRINGⁱ	9606.ENSP00000452120

Protein family/group databases

TCDBⁱ	8.A.54.1.5, the integrin (integrin) family

TCDBⁱ

8.A.54.1.5, the integrin (integrin) family

PTM databases

GlyGenⁱ	Q13683, 5 sites
iPTMnetⁱ	Q13683
PhosphoSitePlusⁱ	Q13683

Genetic variation databases

BioMutaⁱ	ITGA7
DMDMⁱ	308153592

Proteomic databases

EPDⁱ	Q13683
jPOSTⁱ	Q13683
MassIVEⁱ	Q13683
MaxQBⁱ	Q13683
PaxDbⁱ	Q13683
PeptideAtlasⁱ	Q13683
PRIDEⁱ	Q13683
ProteomicsDBⁱ	59654 [Q13683-1] 59655 [Q13683-10] 59656 [Q13683-13] 59657 [Q13683-3] 59658 [Q13683-7] 59659 [Q13683-9]

Protocols and materials databases

Antibodypediaⁱ	1495, 266 antibodies

Antibodypediaⁱ

1495, 266 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000257879; ENSP00000257879; ENSG00000135424 [Q13683-7] ENST00000452168; ENSP00000393844; ENSG00000135424 [Q13683-13] ENST00000553804; ENSP00000452120; ENSG00000135424 [Q13683-3] ENST00000555728; ENSP00000452387; ENSG00000135424 [Q13683-1]
GeneIDⁱ	3679
KEGGⁱ	hsa:3679
UCSCⁱ	uc001shg.4, human [Q13683-1]

Organism-specific databases

CTDⁱ	3679
DisGeNETⁱ	3679
GeneCardsⁱ	ITGA7
HGNCⁱ	HGNC:6143, ITGA7
HPAⁱ	ENSG00000135424, Tissue enhanced (heart muscle, skeletal muscle)
MalaCardsⁱ	ITGA7
MIMⁱ	600536, gene 613204, phenotype
neXtProtⁱ	NX_Q13683
OpenTargetsⁱ	ENSG00000135424
Orphanetⁱ	2020, Congenital fiber-type disproportion myopathy 34520, Congenital muscular dystrophy with integrin alpha-7 deficiency
PharmGKBⁱ	PA29943
VEuPathDBⁱ	HostDB:ENSG00000135424.15
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3637, Eukaryota
GeneTreeⁱ	ENSGT00940000159891
InParanoidⁱ	Q13683
OMAⁱ	HIDFEGT
OrthoDBⁱ	743479at2759
PhylomeDBⁱ	Q13683
TreeFamⁱ	TF105391

Enzyme and pathway databases

PathwayCommonsⁱ	Q13683
Reactomeⁱ	R-HSA-216083, Integrin cell surface interactions R-HSA-3000157, Laminin interactions R-HSA-3000178, ECM proteoglycans
SignaLinkⁱ	Q13683
SIGNORⁱ	Q13683

Miscellaneous databases

BioGRID-ORCSⁱ	3679, 10 hits in 985 CRISPR screens
ChiTaRSⁱ	ITGA7, human
GeneWikiⁱ	ITGA7
GenomeRNAiⁱ	3679
Pharosⁱ	Q13683, Tbio
Protein Ontology More...PROⁱ	PR:Q13683
RNActⁱ	Q13683, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135424, Expressed in heart left ventricle and 225 other tissues
ExpressionAtlasⁱ	Q13683, baseline and differential
Genevisibleⁱ	Q13683, HS

Family and domain databases

Gene3Dⁱ	2.130.10.130, 2 hits
InterProⁱ	View protein in InterPro IPR013517, FG-GAP IPR013519, Int_alpha_beta-p IPR000413, Integrin_alpha IPR013649, Integrin_alpha-2 IPR018184, Integrin_alpha_C_CS IPR028994, Integrin_alpha_N IPR032695, Integrin_dom_sf
Pfamⁱ	View protein in Pfam PF01839, FG-GAP, 2 hits PF08441, Integrin_alpha2, 1 hit
PRINTSⁱ	PR01185, INTEGRINA
SMARTⁱ	View protein in SMART SM00191, Int_alpha, 5 hits
SUPFAMⁱ	SSF69179, SSF69179, 3 hits
PROSITEⁱ	View protein in PROSITE PS51470, FG_GAP, 7 hits PS00242, INTEGRIN_ALPHA, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ITA7_HUMAN
Accessionⁱ	Q13683Primary (citable) accession number: Q13683 Secondary accession number(s): B4E3U0 Q9UEV2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	October 5, 2010
	Last modified:	April 7, 2021
	This is version 200 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Direct protein sequencing, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q13683 (ITA7_HUMAN)

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Integrin alpha-7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ