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Entry version 177 (22 Apr 2020)
Sequence version 4 (14 Oct 2008)
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Protein

Four and a half LIM domains protein 3

Gene

FHL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q13643

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Four and a half LIM domains protein 3
Short name:
FHL-3
Alternative name(s):
Skeletal muscle LIM-protein 2
Short name:
SLIM-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FHL3
Synonyms:SLIM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:3704 FHL3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602790 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13643

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
2275

Open Targets

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OpenTargetsi
ENSG00000183386

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28142

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q13643 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FHL3

Domain mapping of disease mutations (DMDM)

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DMDMi
209572768

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000757402 – 280Four and a half LIM domains protein 3Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei157N6-acetyllysineBy similarity1
Modified residuei235N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13643

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13643

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13643

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13643

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13643

PeptideAtlas

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PeptideAtlasi
Q13643

PRoteomics IDEntifications database

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PRIDEi
Q13643

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
59647

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13643

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13643

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed only in skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000183386 Expressed in gastrocnemius and 132 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13643 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000183386 Group enriched (blood, skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SOX15; the interaction recruits FHL3 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q13643
With#Exp.IntAct
A1CF [Q9NQ94]3EBI-741101,EBI-2809489
ADAM15 [Q13444]3EBI-741101,EBI-77818
AIMP2 [Q13155]12EBI-741101,EBI-745226
AMBP [P02760]3EBI-741101,EBI-2115136
ANKHD1 [A0A0A0MQZ8]4EBI-741101,EBI-11531560
ARID5A [Q03989]3EBI-741101,EBI-948603
ASCL4 [Q6XD76]3EBI-741101,EBI-10254793
BARX2 [Q9UMQ3]3EBI-741101,EBI-12053927
C16orf35 [Q9BTE2]3EBI-741101,EBI-10298364
C1orf94 [Q6P1W5]5EBI-741101,EBI-946029
C9orf116 [Q5BN46]3EBI-741101,EBI-10243636
C9orf116 - isoform 2 [Q5BN46-2]3EBI-741101,EBI-12305735
CASS4 - isoform 2 [Q9NQ75-2]5EBI-741101,EBI-12270182
CBX8 [Q9HC52]5EBI-741101,EBI-712912
CCDC198 [E9PSE9]3EBI-741101,EBI-11748295
CCDC198 [Q9NVL8]3EBI-741101,EBI-10238351
CCDC36 [Q8IYA8]4EBI-741101,EBI-8638439
CLCN2 [A0A0S2Z364]3EBI-741101,EBI-16435545
CNNM3 [Q8NE01]9EBI-741101,EBI-741032
CNNM3 - isoform 3 [Q8NE01-3]3EBI-741101,EBI-10269984
CREB5 - isoform 3 [Q02930-3]3EBI-741101,EBI-10192698
CRIP3 - isoform 3 [Q6Q6R5-3]3EBI-741101,EBI-12925520
CRYBA2 [P53672]3EBI-741101,EBI-750444
CSF1 [P09603]3EBI-741101,EBI-2872294
CTBP2 [P56545]4EBI-741101,EBI-741533
CYSRT1 [A8MQ03]3EBI-741101,EBI-3867333
DCDC2B [A2VCK2]6EBI-741101,EBI-10173222
DLGAP4 - isoform 2 [Q9Y2H0-1]3EBI-741101,EBI-12000556
DMRT3 [Q9NQL9]3EBI-741101,EBI-9679045
E2F8 [A0AVK6]3EBI-741101,EBI-7779316
EFCAB12 [Q6NXP0]3EBI-741101,EBI-10251535
EPHA10 - isoform 3 [Q5JZY3-3]3EBI-741101,EBI-10244652
EPM2AIP1 [Q7L775]3EBI-741101,EBI-6255981
FADS6 [Q8N9I5]3EBI-741101,EBI-3943864
FAM110A [Q9BQ89]3EBI-741101,EBI-1752811
FAM126A [Q9BYI3]3EBI-741101,EBI-11065686
FAM222B [Q8WU58]3EBI-741101,EBI-2807642
FAM71C [Q8NEG0]3EBI-741101,EBI-752049
FAM90A1 [Q86YD7]7EBI-741101,EBI-6658203
FBXL18 [Q96D16]3EBI-741101,EBI-744419
FOSL2 [P15408]4EBI-741101,EBI-3893419
FOXN4 [Q96NZ1]4EBI-741101,EBI-11749712
GATA1 - isoform 2 [P15976-2]4EBI-741101,EBI-9090198
GATA2 [P23769]5EBI-741101,EBI-2806671
GCM2 [O75603]11EBI-741101,EBI-10188645
GUCD1 - isoform 2 [Q96NT3-2]3EBI-741101,EBI-11978177
HAPLN2 [Q9GZV7]3EBI-741101,EBI-11956675
HIPK1 [Q86Z02]4EBI-741101,EBI-692891
HIPK1 - isoform 4 [Q86Z02-4]3EBI-741101,EBI-12025238
HOXA1 [P49639]3EBI-741101,EBI-740785
HSF2BP [O75031]3EBI-741101,EBI-7116203
HYAL2 [Q12891]3EBI-741101,EBI-2806068
IKZF3 [Q9UKT9]4EBI-741101,EBI-747204
ITGB5 [P18084]5EBI-741101,EBI-1223434
KANK2 [Q63ZY3]3EBI-741101,EBI-2556193
KIDINS220 - isoform 2 [Q9ULH0-2]3EBI-741101,EBI-11046235
KIRREL2 [Q6UWL6]3EBI-741101,EBI-10254473
KIRREL2 - isoform 5 [Q6UWL6-5]3EBI-741101,EBI-12794590
KLF12 [Q9Y4X4]3EBI-741101,EBI-750750
KLF3 [P57682]11EBI-741101,EBI-8472267
KPRP [Q5T749]4EBI-741101,EBI-10981970
KRTAP12-1 [P59990]6EBI-741101,EBI-10210845
KRTAP12-2 [P59991]6EBI-741101,EBI-10176379
KTI12 [Q96EK9]3EBI-741101,EBI-7951092
LATS2 [Q9NRM7]4EBI-741101,EBI-3506895
LHB [P01229]3EBI-741101,EBI-11659791
LMO2 [P25791]3EBI-741101,EBI-739696
LMO4 [P61968]3EBI-741101,EBI-2798728
LNX2 [Q8N448]4EBI-741101,EBI-2340947
MMP14 [P50281]3EBI-741101,EBI-992788
MRM3 [Q9HC36]8EBI-741101,EBI-1045440
MRPL27 [Q9P0M9]6EBI-741101,EBI-5325236
MRRF [Q96E11]3EBI-741101,EBI-2855755
MSRB3 - isoform 2 [Q8IXL7-2]3EBI-741101,EBI-10699187
MYBPHL [A2RUH7]3EBI-741101,EBI-9088235
MYOZ3 [Q8TDC0]3EBI-741101,EBI-5662487
MYPOP [Q86VE0]3EBI-741101,EBI-2858213
NDUFAB1 [O14561]5EBI-741101,EBI-1246261
ODF3B [A8MYP8]3EBI-741101,EBI-12010090
P4HA2 - isoform IIa [O15460-2]3EBI-741101,EBI-10182841
PATL1 [Q86TB9]8EBI-741101,EBI-2562092
PHF21A [Q96BD5]7EBI-741101,EBI-745085
PKP2 - isoform 1 [Q99959-2]3EBI-741101,EBI-10987518
PLEKHG4B [Q96PX9]4EBI-741101,EBI-11741362
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-741101,EBI-12000762
PRR35 [P0CG20]3EBI-741101,EBI-11986293
PRR5L [Q6MZQ0]3EBI-741101,EBI-1567866
PTPN6 [P29350]3EBI-741101,EBI-78260
QRICH1 [Q2TAL8]6EBI-741101,EBI-2798044
RAD21 [O60216]4EBI-741101,EBI-80739
RASL12 [Q9NYN1]3EBI-741101,EBI-12917066
RFX3 [P48380]4EBI-741101,EBI-742557
RHEBL1 [Q8TAI7]3EBI-741101,EBI-746555
RSPH14 [Q9UHP6]3EBI-741101,EBI-748350
SAP30BP [Q9UHR5]6EBI-741101,EBI-751683
SAXO1 [Q8IYX7]9EBI-741101,EBI-3957636
SBF2 [Q86WG5]3EBI-741101,EBI-2683289
SDCBP [O00560]3EBI-741101,EBI-727004
SHE [Q5VZ18]3EBI-741101,EBI-3956977
SLAIN1 [Q8ND83]6EBI-741101,EBI-10269374
SLC25A46 [Q96AG3]6EBI-741101,EBI-10281975
SLC44A3 [Q8N4M1]3EBI-741101,EBI-10265585
SLU7 [O95391]3EBI-741101,EBI-750559
SNRPB - isoform SM-B [P14678-2]3EBI-741101,EBI-372475
SNRPC [P09234]3EBI-741101,EBI-766589
SNRPG [P62308]6EBI-741101,EBI-624585
TBC1D22B [Q9NU19]3EBI-741101,EBI-8787464
THAP7 [Q9BT49]3EBI-741101,EBI-741350
THEG [Q9P2T0]4EBI-741101,EBI-751020
TLE5 - isoform 2 [Q08117-2]4EBI-741101,EBI-11741437
TMEM108 [Q6UXF1]3EBI-741101,EBI-7100456
TMSB4X [P62328]3EBI-741101,EBI-712598
TMX3 [Q96JJ7]3EBI-741101,EBI-2514069
TRO [G5E9N2]3EBI-741101,EBI-10178070
TSGA10IP [Q3SY00]5EBI-741101,EBI-10241197
TTLL10 [Q6ZVT0]3EBI-741101,EBI-7844656
TTLL10 - isoform 3 [Q6ZVT0-3]3EBI-741101,EBI-11979997
TUBA3E [Q6PEY2]3EBI-741101,EBI-2551023
TYK2 [P29597]6EBI-741101,EBI-1383454
TYMSOS [Q8TAI1]3EBI-741101,EBI-742060
UBE2Q1 - isoform 2 [Q7Z7E8-2]3EBI-741101,EBI-10258181
VWC2L [B2RUY7]4EBI-741101,EBI-11747707
WDR25 - isoform 2 [Q64LD2-2]3EBI-741101,EBI-12032042
WNK1 [A0A0B4J299]6EBI-741101,EBI-10230525
ZCCHC14 [Q8WYQ9]3EBI-741101,EBI-3937908
ZFP36 [P26651]4EBI-741101,EBI-374248
ZNF417 [Q8TAU3]3EBI-741101,EBI-740727
ZNF512B [Q96KM6]8EBI-741101,EBI-1049952
ZNF587 [Q96SQ5]3EBI-741101,EBI-6427977

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108566, 168 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13643

Database of interacting proteins

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DIPi
DIP-42030N

Protein interaction database and analysis system

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IntActi
Q13643, 168 interactors

Molecular INTeraction database

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MINTi
Q13643

STRING: functional protein association networks

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STRINGi
9606.ENSP00000362107

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13643 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1280
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13643

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q13643

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 92LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini101 – 153LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53
Domaini162 – 212LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST51
Domaini221 – 275LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST55

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1704 Eukaryota
ENOG410XP0W LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_001357_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13643

Identification of Orthologs from Complete Genome Data

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OMAi
QPCFTCS

Database of Orthologous Groups

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OrthoDBi
642235at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13643

TreeFam database of animal gene trees

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TreeFami
TF314113

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR037987 FHL2/3/5
IPR001781 Znf_LIM

The PANTHER Classification System

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PANTHERi
PTHR24205 PTHR24205, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00412 LIM, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00132 LIM, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q13643-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD
60 70 80 90 100
SRELFYEDRH FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ
110 120 130 140 150
CSACGETVMP GSRKLEYGGQ TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC
160 170 180 190 200
VPCYENKFAP RCARCSKTLT QGGVTYRDQP WHRECLVCTG CQTPLAGQQF
210 220 230 240 250
TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE DRHWHHNCFS
260 270 280
CARCSTSLVG QGFVPDGDQV LCQGCSQAGP
Length:280
Mass (Da):31,192
Last modified:October 14, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1A037C260370DFD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82C → R in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti130S → I in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti140S → P in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti157K → N in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti166S → T in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti174V → L in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti179Q → L in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti183 – 184RE → PK in AAC04466 (PubMed:10049693).Curated2
Sequence conflicti250 – 252SCA → TCD in AAC04466 (PubMed:10049693).Curated3
Sequence conflicti252A → D in CAG33706 (Ref. 4) Curated1
Sequence conflicti256T → N in AAC04466 (PubMed:10049693).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U60116 mRNA Translation: AAC04466.2
AK290641 mRNA Translation: BAF83330.1
BT007052 mRNA Translation: AAP35701.1
CR457425 mRNA Translation: CAG33706.1
AL603790 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07301.1
CH471059 Genomic DNA Translation: EAX07302.1
BC001351 mRNA Translation: AAH01351.1
BC011697 mRNA Translation: AAH11697.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30678.1

Protein sequence database of the Protein Information Resource

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PIRi
T09504

NCBI Reference Sequences

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RefSeqi
NP_001230807.1, NM_001243878.1
NP_004459.2, NM_004468.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000373016; ENSP00000362107; ENSG00000183386

Database of genes from NCBI RefSeq genomes

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GeneIDi
2275

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2275

UCSC genome browser

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UCSCi
uc001cck.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60116 mRNA Translation: AAC04466.2
AK290641 mRNA Translation: BAF83330.1
BT007052 mRNA Translation: AAP35701.1
CR457425 mRNA Translation: CAG33706.1
AL603790 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07301.1
CH471059 Genomic DNA Translation: EAX07302.1
BC001351 mRNA Translation: AAH01351.1
BC011697 mRNA Translation: AAH11697.1
CCDSiCCDS30678.1
PIRiT09504
RefSeqiNP_001230807.1, NM_001243878.1
NP_004459.2, NM_004468.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WYHNMR-A101-159[»]
2CUQNMR-A152-218[»]
2EHENMR-A30-99[»]
SMRiQ13643
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108566, 168 interactors
CORUMiQ13643
DIPiDIP-42030N
IntActiQ13643, 168 interactors
MINTiQ13643
STRINGi9606.ENSP00000362107

PTM databases

iPTMnetiQ13643
PhosphoSitePlusiQ13643

Polymorphism and mutation databases

BioMutaiFHL3
DMDMi209572768

Proteomic databases

EPDiQ13643
jPOSTiQ13643
MassIVEiQ13643
MaxQBiQ13643
PaxDbiQ13643
PeptideAtlasiQ13643
PRIDEiQ13643
ProteomicsDBi59647

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31823 157 antibodies

The DNASU plasmid repository

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DNASUi
2275

Genome annotation databases

EnsembliENST00000373016; ENSP00000362107; ENSG00000183386
GeneIDi2275
KEGGihsa:2275
UCSCiuc001cck.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2275
DisGeNETi2275

GeneCards: human genes, protein and diseases

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GeneCardsi
FHL3
HGNCiHGNC:3704 FHL3
HPAiENSG00000183386 Group enriched (blood, skeletal muscle, tongue)
MIMi602790 gene
neXtProtiNX_Q13643
OpenTargetsiENSG00000183386
PharmGKBiPA28142

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00950000183028
HOGENOMiCLU_001357_2_0_1
InParanoidiQ13643
OMAiQPCFTCS
OrthoDBi642235at2759
PhylomeDBiQ13643
TreeFamiTF314113

Enzyme and pathway databases

SignaLinkiQ13643

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FHL3 human
EvolutionaryTraceiQ13643

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FHL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2275
PharosiQ13643 Tbio

Protein Ontology

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PROi
PR:Q13643
RNActiQ13643 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183386 Expressed in gastrocnemius and 132 other tissues
GenevisibleiQ13643 HS

Family and domain databases

InterProiView protein in InterPro
IPR037987 FHL2/3/5
IPR001781 Znf_LIM
PANTHERiPTHR24205 PTHR24205, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFHL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13643
Secondary accession number(s): D3DPT6, Q6I9T0, Q9BVA2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: April 22, 2020
This is version 177 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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