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UniProtKB - Q13643 (FHL3_HUMAN)

Entry version 172 (08 May 2019)
Sequence version 4 (14 Oct 2008)
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Protein

Four and a half LIM domains protein 3

Gene

FHL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13643

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Four and a half LIM domains protein 3
Short name:
FHL-3
Alternative name(s):
Skeletal muscle LIM-protein 2
Short name:
SLIM-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FHL3
Synonyms:SLIM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3704 FHL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602790 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13643

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2275

Open Targets

More...OpenTargetsi		ENSG00000183386

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28142

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FHL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572768

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000757402 – 280Four and a half LIM domains protein 3Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei157N6-acetyllysineBy similarity1
Modified residuei235N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13643

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13643

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13643

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13643

PeptideAtlas

More...PeptideAtlasi		Q13643

PRoteomics IDEntifications database

More...PRIDEi		Q13643

ProteomicsDB human proteome resource

More...ProteomicsDBi		59647

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13643

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13643

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed only in skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183386 Expressed in 133 organ(s), highest expression level in gastrocnemius

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13643 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA045723

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
A1CFQ9NQ943EBI-741101,EBI-2809489
ADAM15Q134443EBI-741101,EBI-77818
AESQ08117-24EBI-741101,EBI-11741437
AIMP2Q1315511EBI-741101,EBI-745226
AMBPP027603EBI-741101,EBI-2115136
ANKHD1A0A0A0MQZ84EBI-741101,EBI-11531560
C16orf35Q9BTE23EBI-741101,EBI-10298364
C9orf116Q5BN463EBI-741101,EBI-10243636
CCDC198Q9NVL83EBI-741101,EBI-10238351
CCDC36Q8IYA84EBI-741101,EBI-8638439
CLCN2A0A0S2Z3643EBI-741101,EBI-16435545
CNNM3Q8NE016EBI-741101,EBI-741032
CNNM3Q8NE01-33EBI-741101,EBI-10269984
CSF1P096033EBI-741101,EBI-2872294
CTBP2Q5SQP84EBI-741101,EBI-11742664
DCDC2BA2VCK25EBI-741101,EBI-10173222
E2F8A0AVK63EBI-741101,EBI-7779316
EFCAB12Q6NXP03EBI-741101,EBI-10251535
EPHA10Q5JZY3-33EBI-741101,EBI-10244652
EPM2AIP1Q7L7753EBI-741101,EBI-6255981
FAM126AQ9BYI33EBI-741101,EBI-11065686
FAM71CQ8NEG03EBI-741101,EBI-752049
FAM90A1Q86YD75EBI-741101,EBI-6658203
FBXL18Q96D163EBI-741101,EBI-744419
FOSL2P154083EBI-741101,EBI-3893419
FOXN4Q96NZ14EBI-741101,EBI-11749712
GATA1P15976-24EBI-741101,EBI-9090198
GATA2P237693EBI-741101,EBI-2806671
GCM2O756038EBI-741101,EBI-10188645
HIPK1Q86Z023EBI-741101,EBI-692891
HYAL2Q128913EBI-741101,EBI-2806068
IKZF3Q9UKT94EBI-741101,EBI-747204
KIRREL2Q6UWL63EBI-741101,EBI-10254473
KLF3P5768210EBI-741101,EBI-8472267
KPRPQ5T7494EBI-741101,EBI-10981970
KRTAP12-1P599905EBI-741101,EBI-10210845
KRTAP12-2P599915EBI-741101,EBI-10176379
KTI12Q96EK93EBI-741101,EBI-7951092
LATS2Q9NRM74EBI-741101,EBI-3506895
LMO2P257913EBI-741101,EBI-739696
LNX2Q8N4484EBI-741101,EBI-2340947
MRM3Q9HC365EBI-741101,EBI-1045440
MRPL27Q9P0M95EBI-741101,EBI-5325236
MYBPHLA2RUH73EBI-741101,EBI-9088235
P4HA2O15460-23EBI-741101,EBI-10182841
PATL1Q86TB95EBI-741101,EBI-2562092
PHF21AQ96BD55EBI-741101,EBI-745085
PLEKHG4BQ96PX94EBI-741101,EBI-11741362
PTPN6P293503EBI-741101,EBI-78260
QRICH1Q2TAL85EBI-741101,EBI-2798044
RAD21O602163EBI-741101,EBI-80739
RFX3P483803EBI-741101,EBI-742557
RHEBL1Q8TAI73EBI-741101,EBI-746555
SAP30BPQ9UHR55EBI-741101,EBI-751683
SAXO1Q8IYX75EBI-741101,EBI-3957636
SLAIN1Q8ND835EBI-741101,EBI-10269374
SLC25A46Q96AG35EBI-741101,EBI-10281975
SLC44A3Q8N4M13EBI-741101,EBI-10265585
SNRPGP623085EBI-741101,EBI-624585
TMX3Q96JJ73EBI-741101,EBI-2514069
TROG5E9N23EBI-741101,EBI-10178070
TTLL10Q6ZVT03EBI-741101,EBI-7844656
TYK2P295975EBI-741101,EBI-1383454
TYMSOSQ8TAI15EBI-741101,EBI-742060
UBE2Q1Q7Z7E8-23EBI-741101,EBI-10258181
VWC2LB2RUY74EBI-741101,EBI-11747707
WNK1A0A0B4J2995EBI-741101,EBI-10230525
ZFP36M0QY764EBI-741101,EBI-11743638
ZNF417Q8TAU33EBI-741101,EBI-740727
ZNF512BQ96KM65EBI-741101,EBI-1049952

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108566, 162 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q13643

Database of interacting proteins

More...DIPi		DIP-42030N

Protein interaction database and analysis system

More...IntActi		Q13643, 146 interactors

Molecular INTeraction database

More...MINTi		Q13643

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362107

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1280
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13643

Database of comparative protein structure models

More...ModBasei		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13643

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 92LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini101 – 153LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53
Domaini162 – 212LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST51
Domaini221 – 275LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST55

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1704 Eukaryota
ENOG410XP0W LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231075

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13643

Identification of Orthologs from Complete Genome Data

More...OMAi		CFGNLYA

Database of Orthologous Groups

More...OrthoDBi		642235at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13643

TreeFam database of animal gene trees

More...TreeFami		TF314113

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037987 FHL2/3/5
IPR001781 Znf_LIM

The PANTHER Classification System

More...PANTHERi		PTHR24205 PTHR24205, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00412 LIM, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00132 LIM, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q13643-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD 
        60         70         80         90        100
SRELFYEDRH FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ 
       110        120        130        140        150
CSACGETVMP GSRKLEYGGQ TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC 
       160        170        180        190        200
VPCYENKFAP RCARCSKTLT QGGVTYRDQP WHRECLVCTG CQTPLAGQQF 
       210        220        230        240        250
TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE DRHWHHNCFS 
       260        270        280
CARCSTSLVG QGFVPDGDQV LCQGCSQAGP
Length:280
Mass (Da):31,192
Last modified:October 14, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1A037C260370DFD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82C → R in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti130S → I in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti140S → P in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti157K → N in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti166S → T in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti174V → L in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti179Q → L in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti183 – 184RE → PK in AAC04466 (PubMed:10049693).Curated2
Sequence conflicti250 – 252SCA → TCD in AAC04466 (PubMed:10049693).Curated3
Sequence conflicti252A → D in CAG33706 (Ref. 4) Curated1
Sequence conflicti256T → N in AAC04466 (PubMed:10049693).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U60116 mRNA Translation: AAC04466.2
AK290641 mRNA Translation: BAF83330.1
BT007052 mRNA Translation: AAP35701.1
CR457425 mRNA Translation: CAG33706.1
AL603790 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07301.1
CH471059 Genomic DNA Translation: EAX07302.1
BC001351 mRNA Translation: AAH01351.1
BC011697 mRNA Translation: AAH11697.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30678.1

Protein sequence database of the Protein Information Resource

More...PIRi		T09504

NCBI Reference Sequences

More...RefSeqi		NP_001230807.1, NM_001243878.1
NP_004459.2, NM_004468.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373016; ENSP00000362107; ENSG00000183386

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2275

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2275

UCSC genome browser

More...UCSCi		uc001cck.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60116 mRNA Translation: AAC04466.2
AK290641 mRNA Translation: BAF83330.1
BT007052 mRNA Translation: AAP35701.1
CR457425 mRNA Translation: CAG33706.1
AL603790 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07301.1
CH471059 Genomic DNA Translation: EAX07302.1
BC001351 mRNA Translation: AAH01351.1
BC011697 mRNA Translation: AAH11697.1
CCDSiCCDS30678.1
PIRiT09504
RefSeqiNP_001230807.1, NM_001243878.1
NP_004459.2, NM_004468.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WYHNMR-A101-159[»]
2CUQNMR-A152-218[»]
2EHENMR-A30-99[»]
SMRiQ13643
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108566, 162 interactors
CORUMiQ13643
DIPiDIP-42030N
IntActiQ13643, 146 interactors
MINTiQ13643
STRINGi9606.ENSP00000362107

PTM databases

iPTMnetiQ13643
PhosphoSitePlusiQ13643

Polymorphism and mutation databases

BioMutaiFHL3
DMDMi209572768

Proteomic databases

EPDiQ13643
jPOSTiQ13643
MaxQBiQ13643
PaxDbiQ13643
PeptideAtlasiQ13643
PRIDEiQ13643
ProteomicsDBi59647

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		2275
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373016; ENSP00000362107; ENSG00000183386
GeneIDi2275
KEGGihsa:2275
UCSCiuc001cck.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2275
DisGeNETi2275

GeneCards: human genes, protein and diseases

More...GeneCardsi		FHL3
HGNCiHGNC:3704 FHL3
HPAiHPA045723
MIMi602790 gene
neXtProtiNX_Q13643
OpenTargetsiENSG00000183386
PharmGKBiPA28142

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00950000183028
HOGENOMiHOG000231075
InParanoidiQ13643
OMAiCFGNLYA
OrthoDBi642235at2759
PhylomeDBiQ13643
TreeFamiTF314113

Enzyme and pathway databases

SignaLinkiQ13643

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FHL3 human
EvolutionaryTraceiQ13643

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FHL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2275

Protein Ontology

More...PROi		PR:Q13643

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000183386 Expressed in 133 organ(s), highest expression level in gastrocnemius
GenevisibleiQ13643 HS

Family and domain databases

InterProiView protein in InterPro
IPR037987 FHL2/3/5
IPR001781 Znf_LIM
PANTHERiPTHR24205 PTHR24205, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFHL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13643
Secondary accession number(s): D3DPT6, Q6I9T0, Q9BVA2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: May 8, 2019
This is version 172 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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