UniProtKB - Q13643 (FHL3_HUMAN)
Protein
Four and a half LIM domains protein 3
Gene
FHL3
Organism
Homo sapiens (Human)
Status
Functioni
Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 7 – 31 | C4-typeSequence analysisAdd BLAST | 25 |
GO - Molecular functioni
- actin binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- muscle organ development Source: ProtInc
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q13643 |
SignaLinki | Q13643 |
Names & Taxonomyi
Protein namesi | Recommended name: Four and a half LIM domains protein 3Short name: FHL-3 Alternative name(s): Skeletal muscle LIM-protein 2 Short name: SLIM-2 |
Gene namesi | Name:FHL3 Synonyms:SLIM2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183386.9 |
HGNCi | HGNC:3704, FHL3 |
MIMi | 602790, gene |
neXtProti | NX_Q13643 |
Subcellular locationi
Cytoskeleton
- stress fiber Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Other locations
- focal adhesion Source: UniProtKB
- Z disc Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 2275 |
OpenTargetsi | ENSG00000183386 |
PharmGKBi | PA28142 |
Miscellaneous databases
Pharosi | Q13643, Tbio |
Polymorphism and mutation databases
BioMutai | FHL3 |
DMDMi | 209572768 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000075740 | 2 – 280 | Four and a half LIM domains protein 3Add BLAST | 279 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 157 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 235 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q13643 |
jPOSTi | Q13643 |
MassIVEi | Q13643 |
MaxQBi | Q13643 |
PaxDbi | Q13643 |
PeptideAtlasi | Q13643 |
PRIDEi | Q13643 |
ProteomicsDBi | 59647 |
PTM databases
iPTMneti | Q13643 |
PhosphoSitePlusi | Q13643 |
Expressioni
Tissue specificityi
Expressed only in skeletal muscle.
Gene expression databases
Bgeei | ENSG00000183386, Expressed in gastrocnemius and 154 other tissues |
Genevisiblei | Q13643, HS |
Organism-specific databases
HPAi | ENSG00000183386, Group enriched (blood, skeletal muscle, tongue) |
Interactioni
Subunit structurei
Interacts with SOX15; the interaction recruits FHL3 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.
By similarityBinary interactionsi
Q13643
GO - Molecular functioni
- actin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 108566, 227 interactors |
CORUMi | Q13643 |
DIPi | DIP-42030N |
IntActi | Q13643, 168 interactors |
MINTi | Q13643 |
STRINGi | 9606.ENSP00000362107 |
Miscellaneous databases
RNActi | Q13643, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q13643 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13643 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 92 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 101 – 153 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 162 – 212 | LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 221 – 275 | LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST | 55 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 7 – 31 | C4-typeSequence analysisAdd BLAST | 25 |
Keywords - Domaini
LIM domain, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1704, Eukaryota |
GeneTreei | ENSGT00950000183028 |
HOGENOMi | CLU_001357_2_0_1 |
InParanoidi | Q13643 |
OMAi | RILCRDC |
OrthoDBi | 642235at2759 |
PhylomeDBi | Q13643 |
TreeFami | TF314113 |
Family and domain databases
InterProi | View protein in InterPro IPR037987, FHL2/3/5 IPR001781, Znf_LIM |
PANTHERi | PTHR24205, PTHR24205, 1 hit |
Pfami | View protein in Pfam PF00412, LIM, 4 hits |
SMARTi | View protein in SMART SM00132, LIM, 4 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 4 hits PS50023, LIM_DOMAIN_2, 4 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q13643-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSESFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD
60 70 80 90 100
SRELFYEDRH FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ
110 120 130 140 150
CSACGETVMP GSRKLEYGGQ TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC
160 170 180 190 200
VPCYENKFAP RCARCSKTLT QGGVTYRDQP WHRECLVCTG CQTPLAGQQF
210 220 230 240 250
TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE DRHWHHNCFS
260 270 280
CARCSTSLVG QGFVPDGDQV LCQGCSQAGP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 82 | C → R in AAC04466 (PubMed:10049693).Curated | 1 | |
Sequence conflicti | 130 | S → I in AAC04466 (PubMed:10049693).Curated | 1 | |
Sequence conflicti | 140 | S → P in AAC04466 (PubMed:10049693).Curated | 1 | |
Sequence conflicti | 157 | K → N in AAC04466 (PubMed:10049693).Curated | 1 | |
Sequence conflicti | 166 | S → T in AAC04466 (PubMed:10049693).Curated | 1 | |
Sequence conflicti | 174 | V → L in AAC04466 (PubMed:10049693).Curated | 1 | |
Sequence conflicti | 179 | Q → L in AAC04466 (PubMed:10049693).Curated | 1 | |
Sequence conflicti | 183 – 184 | RE → PK in AAC04466 (PubMed:10049693).Curated | 2 | |
Sequence conflicti | 250 – 252 | SCA → TCD in AAC04466 (PubMed:10049693).Curated | 3 | |
Sequence conflicti | 252 | A → D in CAG33706 (Ref. 4) Curated | 1 | |
Sequence conflicti | 256 | T → N in AAC04466 (PubMed:10049693).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U60116 mRNA Translation: AAC04466.2 AK290641 mRNA Translation: BAF83330.1 BT007052 mRNA Translation: AAP35701.1 CR457425 mRNA Translation: CAG33706.1 AL603790 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07301.1 CH471059 Genomic DNA Translation: EAX07302.1 BC001351 mRNA Translation: AAH01351.1 BC011697 mRNA Translation: AAH11697.1 |
CCDSi | CCDS30678.1 |
PIRi | T09504 |
RefSeqi | NP_001230807.1, NM_001243878.1 NP_004459.2, NM_004468.4 |
Genome annotation databases
Ensembli | ENST00000373016; ENSP00000362107; ENSG00000183386 |
GeneIDi | 2275 |
KEGGi | hsa:2275 |
UCSCi | uc001cck.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U60116 mRNA Translation: AAC04466.2 AK290641 mRNA Translation: BAF83330.1 BT007052 mRNA Translation: AAP35701.1 CR457425 mRNA Translation: CAG33706.1 AL603790 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07301.1 CH471059 Genomic DNA Translation: EAX07302.1 BC001351 mRNA Translation: AAH01351.1 BC011697 mRNA Translation: AAH11697.1 |
CCDSi | CCDS30678.1 |
PIRi | T09504 |
RefSeqi | NP_001230807.1, NM_001243878.1 NP_004459.2, NM_004468.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WYH | NMR | - | A | 101-159 | [»] | |
2CUQ | NMR | - | A | 152-218 | [»] | |
2EHE | NMR | - | A | 30-99 | [»] | |
SMRi | Q13643 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108566, 227 interactors |
CORUMi | Q13643 |
DIPi | DIP-42030N |
IntActi | Q13643, 168 interactors |
MINTi | Q13643 |
STRINGi | 9606.ENSP00000362107 |
PTM databases
iPTMneti | Q13643 |
PhosphoSitePlusi | Q13643 |
Polymorphism and mutation databases
BioMutai | FHL3 |
DMDMi | 209572768 |
Proteomic databases
EPDi | Q13643 |
jPOSTi | Q13643 |
MassIVEi | Q13643 |
MaxQBi | Q13643 |
PaxDbi | Q13643 |
PeptideAtlasi | Q13643 |
PRIDEi | Q13643 |
ProteomicsDBi | 59647 |
Protocols and materials databases
Antibodypediai | 31823, 160 antibodies |
DNASUi | 2275 |
Genome annotation databases
Ensembli | ENST00000373016; ENSP00000362107; ENSG00000183386 |
GeneIDi | 2275 |
KEGGi | hsa:2275 |
UCSCi | uc001cck.4, human |
Organism-specific databases
CTDi | 2275 |
DisGeNETi | 2275 |
EuPathDBi | HostDB:ENSG00000183386.9 |
GeneCardsi | FHL3 |
HGNCi | HGNC:3704, FHL3 |
HPAi | ENSG00000183386, Group enriched (blood, skeletal muscle, tongue) |
MIMi | 602790, gene |
neXtProti | NX_Q13643 |
OpenTargetsi | ENSG00000183386 |
PharmGKBi | PA28142 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1704, Eukaryota |
GeneTreei | ENSGT00950000183028 |
HOGENOMi | CLU_001357_2_0_1 |
InParanoidi | Q13643 |
OMAi | RILCRDC |
OrthoDBi | 642235at2759 |
PhylomeDBi | Q13643 |
TreeFami | TF314113 |
Enzyme and pathway databases
PathwayCommonsi | Q13643 |
SignaLinki | Q13643 |
Miscellaneous databases
BioGRID-ORCSi | 2275, 11 hits in 857 CRISPR screens |
ChiTaRSi | FHL3, human |
EvolutionaryTracei | Q13643 |
GeneWikii | FHL3 |
GenomeRNAii | 2275 |
Pharosi | Q13643, Tbio |
PROi | PR:Q13643 |
RNActi | Q13643, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183386, Expressed in gastrocnemius and 154 other tissues |
Genevisiblei | Q13643, HS |
Family and domain databases
InterProi | View protein in InterPro IPR037987, FHL2/3/5 IPR001781, Znf_LIM |
PANTHERi | PTHR24205, PTHR24205, 1 hit |
Pfami | View protein in Pfam PF00412, LIM, 4 hits |
SMARTi | View protein in SMART SM00132, LIM, 4 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 4 hits PS50023, LIM_DOMAIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FHL3_HUMAN | |
Accessioni | Q13643Primary (citable) accession number: Q13643 Secondary accession number(s): D3DPT6, Q6I9T0, Q9BVA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 14, 2008 | |
Last modified: | December 2, 2020 | |
This is version 181 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM