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UniProtKB - Q13642 (FHL1_HUMAN)

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Protein

Four and a half LIM domains protein 1

Gene

FHL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have an involvement in muscle development or hypertrophy.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

GO - Molecular functioni

  • ion channel binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • animal organ morphogenesis Source: UniProtKB
  • cell differentiation Source: UniProtKB-KW
  • muscle organ development Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
  • negative regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
  • positive regulation of potassium ion transport Source: BHF-UCL
  • regulation of membrane depolarization Source: BHF-UCL
  • regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ13642

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 1
Short name:
FHL-1
Alternative name(s):
Skeletal muscle LIM-protein 1
Short name:
SLIM
Short name:
SLIM-1
Gene namesi
Name:FHL1
Synonyms:SLIM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000022267.16
HGNCiHGNC:3702 FHL1
MIMi300163 gene
neXtProtiNX_Q13642

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Emery-Dreifuss muscular dystrophy 6, X-linked (EDMD6)1 Publication
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
Disease descriptionA form of Emery-Dreifuss muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.
See also OMIM:300696
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075357209C → R in EDMD6. 1 PublicationCorresponds to variant dbSNP:rs122459149EnsemblClinVar.1
Natural variantiVAR_075358276C → Y in EDMD6; drastically reduced protein levels in muscle. 1 Publication1
Scapuloperoneal myopathy, X-linked dominant (SPM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by progressive muscle weakness and wasting, upper and lower limbs weakness, foot drop, scapular winging, and myopathic changes on muscle biopsy. Most affected individuals become wheelchair-bound.
See also OMIM:300695
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042603122W → S in SPM. 1 PublicationCorresponds to variant dbSNP:rs122458140EnsemblClinVar.1
Natural variantiVAR_076566154H → P in SPM. 1 Publication1
Myopathy, X-linked, with postural muscle atrophy (XMPMA)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA progressive muscular dystrophy with onset in adulthood. Affected individuals develop a proximal myopathy characterized by specific atrophy of postural muscles, limited neck flexion, bent spine, contractures of the Achilles tendon, respiratory problems, and cardiomyopathy. Patients may show muscle hypertrophy in the early stages of the disorder.
See also OMIM:300696
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042604128T → TI in XMPMA. 1 Publication1
Natural variantiVAR_042605224C → W in XMPMA. 2 PublicationsCorresponds to variant dbSNP:rs122458141EnsemblClinVar.1
Natural variantiVAR_075359280V → M in XMPMA. 1 PublicationCorresponds to variant dbSNP:rs267606811EnsemblClinVar.1
Isoform 1 (identifier: Q13642-1)
Natural varianti246H → Y in XMPMA, unknown pathological significance. 1 Publication1
Reducing body myopathy, X-linked 1A, severe, with infantile or early childhood onset (RBMX1A)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare myopathy clinically characterized by rapidly progressive muscular weakness, and pathologically by the presence of intracytoplasmic inclusion bodies strongly stained by menadione-linked alpha-glycerophosphate dehydrogenase in the absence of substrate, alpha-glycerophosphate. The term 'reducing body' refers to the reducing activity of the inclusions to nitroblue tetrazolium in the absence of substrate. This condition is also commonly associated with rimmed vacuoles and cytoplasmic bodies. Death in childhood is frequent in the severe form of the disease, due to respiratory failure.
See also OMIM:300717
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075350101C → F in RBMX1A; unknown pathological significance. 1 Publication1
Natural variantiVAR_075353123H → L in RBMX1A. 1 PublicationCorresponds to variant dbSNP:rs267606812EnsemblClinVar.1
Natural variantiVAR_075354123H → Q in RBMX1A. 1 PublicationCorresponds to variant dbSNP:rs267606813EnsemblClinVar.1
Natural variantiVAR_045999123H → Y in RBMX1A; the mutant protein initiates aggregation of the FHL1 protein causing reducing bodies formation; dominant-negative effect. 2 PublicationsCorresponds to variant dbSNP:rs122458142EnsemblClinVar.1
Natural variantiVAR_046000132C → F in RBMX1A; the mutant protein initiates aggregation of the FHL1 protein causing reducing bodies formation; dominant-negative effect. 2 PublicationsCorresponds to variant dbSNP:rs122458143EnsemblClinVar.1
Natural variantiVAR_075356150C → Y in RBMX1A; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs122459146EnsemblClinVar.1
Reducing body myopathy, X-linked 1B, with late childhood or adult onset (RBMX1B)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare myopathy clinically characterized by rapidly progressive muscular weakness, and pathologically by the presence of intracytoplasmic inclusion bodies strongly stained by menadione-linked alpha-glycerophosphate dehydrogenase in the absence of substrate, alpha-glycerophosphate. The term 'reducing body' refers to the reducing activity of the inclusions to nitroblue tetrazolium in the absence of substrate. This condition is also commonly associated with rimmed vacuoles and cytoplasmic bodies.
See also OMIM:300718
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075351102 – 104Missing in RBMX1B; unknown pathological significance. 1 Publication3
Natural variantiVAR_075352104C → R in RBMX1B; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs122459147EnsemblClinVar.1
Natural variantiVAR_075355150C → S in RBMX1B. 1 Publication1
Natural variantiVAR_046001153C → R in RBMX1B. 2 PublicationsCorresponds to variant dbSNP:rs122458144EnsemblClinVar.1
Natural variantiVAR_046002153C → Y in RBMX1B. 2 PublicationsCorresponds to variant dbSNP:rs122458145EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Emery-Dreifuss muscular dystrophy

Organism-specific databases

DisGeNETi2273
GeneReviewsiFHL1
MalaCardsiFHL1
MIMi300695 phenotype
300696 phenotype
300717 phenotype
300718 phenotype
OpenTargetsiENSG00000022267
Orphaneti155 Familial isolated hypertrophic cardiomyopathy
97239 Reducing body myopathy
98863 X-linked Emery-Dreifuss muscular dystrophy
178461 X-linked myopathy with postural muscle atrophy
PharmGKBiPA28141

Polymorphism and mutation databases

BioMutaiFHL1
DMDMi59800384

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000757352 – 323Four and a half LIM domains protein 1Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4N6-acetyllysineBy similarity1
Cross-linki86Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ13642
PeptideAtlasiQ13642
PRIDEiQ13642
ProteomicsDBi59642
59643 [Q13642-1]
59644 [Q13642-3]
59645 [Q13642-4]
59646 [Q13642-5]
TopDownProteomicsiQ13642-1 [Q13642-1]

PTM databases

iPTMnetiQ13642
PhosphoSitePlusiQ13642

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in skeletal muscle and to a lesser extent in heart, placenta, ovary, prostate, testis, small intestine, colon and spleen. Expression is barely detectable in brain, lung, liver, kidney, pancreas, thymus and peripheral blood leukocytes. Isoform 2 is expressed in brain, skeletal muscle and to a lesser extent in heart, colon, prostate and small intestine. Isoform 3 is expressed in testis, heart and skeletal muscle.5 Publications

Developmental stagei

Elevated levels during postnatal muscle growth.1 Publication

Gene expression databases

BgeeiENSG00000022267
ExpressionAtlasiQ13642 baseline and differential
GenevisibleiQ13642 HS

Organism-specific databases

HPAiCAB020817
HPA001040
HPA001391

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • ion channel binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi108564, 35 interactors
CORUMiQ13642
IntActiQ13642, 29 interactors
MINTiQ13642
STRINGi9606.ENSP00000071281

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 43Combined sources3
Beta strandi49 – 51Combined sources3
Beta strandi53 – 56Combined sources4
Beta strandi59 – 62Combined sources4
Turni63 – 65Combined sources3
Beta strandi69 – 71Combined sources3
Beta strandi81 – 83Combined sources3
Beta strandi86 – 88Combined sources3
Helixi90 – 93Combined sources4
Beta strandi102 – 104Combined sources3
Beta strandi110 – 112Combined sources3
Beta strandi114 – 116Combined sources3
Beta strandi121 – 123Combined sources3
Turni124 – 126Combined sources3
Beta strandi130 – 132Combined sources3
Beta strandi141 – 144Combined sources4
Beta strandi147 – 150Combined sources4
Helixi151 – 157Combined sources7
Beta strandi163 – 165Combined sources3
Beta strandi174 – 176Combined sources3
Beta strandi179 – 181Combined sources3
Turni183 – 186Combined sources4
Turni189 – 191Combined sources3
Beta strandi200 – 202Combined sources3
Beta strandi207 – 209Combined sources3
Helixi210 – 217Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X63NMR-A91-159[»]
2CUPNMR-A40-127[»]
2CURNMR-A162-217[»]
2EGQNMR-A211-280[»]
ProteinModelPortaliQ13642
SMRiQ13642
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13642

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 92LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini101 – 153LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53
Domaini162 – 212LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST51

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410INGD Eukaryota
ENOG410YDMU LUCA
GeneTreeiENSGT00760000118910
HOVERGENiHBG074526
InParanoidiQ13642
KOiK14365
OMAiAYEGQSW
OrthoDBiEOG091G07C5
PhylomeDBiQ13642
TreeFamiTF318571

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 3 hits

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q13642-2) [UniParc]FASTAAdd to basket
Also known as: FHL1B, SLIMMER

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEKFDCHYC RDPLQGKKYV QKDGHHCCLK CFDKFCANTC VECRKPIGAD 
        60         70         80         90        100
SKEVHYKNRF WHDTCFRCAK CLHPLANETF VAKDNKILCN KCTTREDSPK 
       110        120        130        140        150
CKGCFKAIVA GDQNVEYKGT VWHKDCFTCS NCKQVIGTGS FFPKGEDFYC 
       160        170        180        190        200
VTCHETKFAK HCVKCNKAIT SGGITYQDQP WHADCFVCVT CSKKLAGQRF 
       210        220        230        240        250
TAVEDQYYCV DCYKNFVAKK CAGCKNPITG KRTVSRVSHP VSKARKPPVC 
       260        270        280        290        300
HGKRLPLTLF PSANLRGRHP GGERTCPSWV VVLYRKNRSL AAPRGPGLVK 
       310        320 
APVWWPMKDN PGTTTASTAK NAP
Length:323
Mass (Da):36,263
Last modified:January 23, 2007 - v4
Checksum:i50FD17F7B2606823
GO
Isoform 1 (identifier: Q13642-1) [UniParc]FASTAAdd to basket
Also known as: FHL1, FHL1A, SLIM1

The sequence of this isoform differs from the canonical sequence as follows:
     231-323: KRTVSRVSHP...TTASTAKNAP → FGKGSSVVAY...VYCPDCAKKL

Show »
Length:280
Mass (Da):31,895
Checksum:i2FC873D70E62834D
GO
Isoform 3 (identifier: Q13642-3) [UniParc]FASTAAdd to basket
Also known as: FHL1C

The sequence of this isoform differs from the canonical sequence as follows:
     168-296: Missing.

Show »
Length:194
Mass (Da):22,017
Checksum:i2DBD610944FFE5EC
GO
Isoform 4 (identifier: Q13642-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTFYVASLALELIWMLSSPAGPSSYKVGTM
     231-323: KRTVSRVSHP...TTASTAKNAP → FGKGSSVVAY...VYCPDCAKKL

Note: No experimental confirmation available.
Show »
Length:309
Mass (Da):34,997
Checksum:i70D165A814166097
GO
Isoform 5 (identifier: Q13642-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MASHRHSGPSSYKVGTM
     231-323: KRTVSRVSHP...TTASTAKNAP → FGKGSSVVAY...VYCPDCAKKL

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):33,579
Checksum:i24EAD21C9DEF4DAD
GO

Sequence cautioni

The sequence AAH88369 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI41055 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73H → Q in AAC52021 (PubMed:8753811).Curated1
Sequence conflicti81 – 91VAKDNKILCNK → CGQGQQRSCAQ in AAD21579 (PubMed:10352231).CuratedAdd BLAST11
Sequence conflicti98S → F (PubMed:8753811).Curated1
Sequence conflicti98S → F (PubMed:10352231).Curated1
Sequence conflicti158F → L (PubMed:8753811).Curated1
Sequence conflicti158F → L (PubMed:7626119).Curated1
Sequence conflicti239H → R in AAC72390 (PubMed:10524257).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075350101C → F in RBMX1A; unknown pathological significance. 1 Publication1
Natural variantiVAR_075351102 – 104Missing in RBMX1B; unknown pathological significance. 1 Publication3
Natural variantiVAR_075352104C → R in RBMX1B; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs122459147EnsemblClinVar.1
Natural variantiVAR_042603122W → S in SPM. 1 PublicationCorresponds to variant dbSNP:rs122458140EnsemblClinVar.1
Natural variantiVAR_075353123H → L in RBMX1A. 1 PublicationCorresponds to variant dbSNP:rs267606812EnsemblClinVar.1
Natural variantiVAR_075354123H → Q in RBMX1A. 1 PublicationCorresponds to variant dbSNP:rs267606813EnsemblClinVar.1
Natural variantiVAR_045999123H → Y in RBMX1A; the mutant protein initiates aggregation of the FHL1 protein causing reducing bodies formation; dominant-negative effect. 2 PublicationsCorresponds to variant dbSNP:rs122458142EnsemblClinVar.1
Natural variantiVAR_042604128T → TI in XMPMA. 1 Publication1
Natural variantiVAR_046000132C → F in RBMX1A; the mutant protein initiates aggregation of the FHL1 protein causing reducing bodies formation; dominant-negative effect. 2 PublicationsCorresponds to variant dbSNP:rs122458143EnsemblClinVar.1
Natural variantiVAR_075355150C → S in RBMX1B. 1 Publication1
Natural variantiVAR_075356150C → Y in RBMX1A; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs122459146EnsemblClinVar.1
Natural variantiVAR_046001153C → R in RBMX1B. 2 PublicationsCorresponds to variant dbSNP:rs122458144EnsemblClinVar.1
Natural variantiVAR_046002153C → Y in RBMX1B. 2 PublicationsCorresponds to variant dbSNP:rs122458145EnsemblClinVar.1
Natural variantiVAR_076566154H → P in SPM. 1 Publication1
Natural variantiVAR_075357209C → R in EDMD6. 1 PublicationCorresponds to variant dbSNP:rs122459149EnsemblClinVar.1
Natural variantiVAR_042605224C → W in XMPMA. 2 PublicationsCorresponds to variant dbSNP:rs122458141EnsemblClinVar.1
Natural variantiVAR_075358276C → Y in EDMD6; drastically reduced protein levels in muscle. 1 Publication1
Natural variantiVAR_075359280V → M in XMPMA. 1 PublicationCorresponds to variant dbSNP:rs267606811EnsemblClinVar.1
Isoform 1 (identifier: Q13642-1)
Natural varianti246H → Y in XMPMA, unknown pathological significance. 1 Publication1
Natural varianti275D → N1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0431621M → MTFYVASLALELIWMLSSPA GPSSYKVGTM in isoform 4. 1 Publication1
Alternative sequenceiVSP_0434041M → MASHRHSGPSSYKVGTM in isoform 5. 1 Publication1
Alternative sequenceiVSP_010693168 – 296Missing in isoform 3. 1 PublicationAdd BLAST129
Alternative sequenceiVSP_010694231 – 323KRTVS…AKNAP → FGKGSSVVAYEGQSWHDYCF HCKKCSVNLANKRFVFHQEQ VYCPDCAKKL in isoform 1, isoform 4 and isoform 5. 6 PublicationsAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60115 mRNA Translation: AAC52021.1
U29538 mRNA Translation: AAC35421.1
AF110763 Genomic DNA Translation: AAD21579.1
AF098518 mRNA Translation: AAC72390.1
AF063002 mRNA Translation: AAC72886.1
AF220153 mRNA Translation: AAF32351.1
AK122708 mRNA Translation: BAG53680.1
AK289411 mRNA Translation: BAF82100.1
AK299381 mRNA Translation: BAH13020.1
AK301642 mRNA Translation: BAH13529.1
CR456974 mRNA Translation: CAG33255.1
AL078638 Genomic DNA Translation: CAC18881.1
AL078638 Genomic DNA Translation: CAI41062.1
AL078638 Genomic DNA Translation: CAI41055.1 Different initiation.
CH471150 Genomic DNA Translation: EAW88476.1
CH471150 Genomic DNA Translation: EAW88478.1
CH471150 Genomic DNA Translation: EAW88479.1
BC010998 mRNA Translation: AAH10998.1
BC088369 mRNA Translation: AAH88369.1 Different initiation.
U60118 mRNA Translation: AAC50795.1
CCDSiCCDS14655.1 [Q13642-1]
CCDS55505.1 [Q13642-4]
CCDS55506.1 [Q13642-5]
CCDS55507.1 [Q13642-2]
CCDS76036.1 [Q13642-3]
PIRiG01884
JC4893 G02741
RefSeqiNP_001153171.1, NM_001159699.1 [Q13642-5]
NP_001153172.1, NM_001159700.1 [Q13642-1]
NP_001153173.1, NM_001159701.1 [Q13642-4]
NP_001153174.1, NM_001159702.2 [Q13642-2]
NP_001153175.1, NM_001159703.1 [Q13642-3]
NP_001153176.1, NM_001159704.1 [Q13642-1]
NP_001161291.1, NM_001167819.1 [Q13642-1]
NP_001440.2, NM_001449.4 [Q13642-1]
XP_006724807.1, XM_006724744.2 [Q13642-2]
XP_006724808.1, XM_006724745.3 [Q13642-2]
XP_006724809.1, XM_006724746.2 [Q13642-2]
XP_006724810.1, XM_006724747.2 [Q13642-1]
XP_016884846.1, XM_017029357.1 [Q13642-1]
UniGeneiHs.435369

Genome annotation databases

EnsembliENST00000345434; ENSP00000071281; ENSG00000022267 [Q13642-2]
ENST00000370683; ENSP00000359717; ENSG00000022267 [Q13642-5]
ENST00000370690; ENSP00000359724; ENSG00000022267 [Q13642-1]
ENST00000394153; ENSP00000377709; ENSG00000022267 [Q13642-1]
ENST00000394155; ENSP00000377710; ENSG00000022267 [Q13642-2]
ENST00000535737; ENSP00000444815; ENSG00000022267 [Q13642-1]
ENST00000539015; ENSP00000437673; ENSG00000022267 [Q13642-4]
ENST00000543669; ENSP00000443333; ENSG00000022267 [Q13642-1]
ENST00000618438; ENSP00000477609; ENSG00000022267 [Q13642-3]
ENST00000628568; ENSP00000486782; ENSG00000022267 [Q13642-1]
ENST00000629039; ENSP00000486439; ENSG00000022267 [Q13642-1]
ENST00000630084; ENSP00000485897; ENSG00000022267 [Q13642-1]
GeneIDi2273
KEGGihsa:2273
UCSCiuc004ezl.3 human [Q13642-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFHL1_HUMAN
AccessioniPrimary (citable) accession number: Q13642
Secondary accession number(s): B7Z5T4
, B7Z793, O95212, Q13230, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 183 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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