RAB31

Functionⁱ

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.5 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	12 – 19	GTP	8
Nucleotide bindingⁱ	60 – 64	GTP	5
Nucleotide bindingⁱ	118 – 121	GTP	4

GO - Molecular functionⁱ

GDP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17189207
GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17189207

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to insulin stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17189207
Golgi to plasma membrane protein transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17678623
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neutrophil degranulation Source: Reactome
phagosome maturation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21255211
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
receptor internalization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19725050
regulated exocytosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17189207

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-8873719 RAB geranylgeranylation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-31 Alternative name(s): Ras-related protein Rab-22B
Gene namesⁱ	Name:RAB31 Synonyms:RAB22B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168461.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9771 RAB31
MIMⁱ	605694 gene
neXtProtⁱ	NX_Q13636

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	64	Q → L: No change in GTPase activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11031
PharmGKBⁱ	PA34122

Polymorphism and mutation databases

BioMutaⁱ	RAB31
DMDMⁱ	2500069

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000121232	1 – 194	Ras-related protein Rab-31Add BLAST		194

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	35	PhosphoserineCombined sources	1
Lipidationⁱ	193	S-geranylgeranyl cysteineBy similarity	1
Lipidationⁱ	194	S-geranylgeranyl cysteineBy similarity	1

Keywords - PTMⁱ

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDⁱ	Q13636
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13636
PaxDbⁱ	Q13636
PeptideAtlas More...PeptideAtlasⁱ	Q13636
PRIDEⁱ	Q13636
ProteomicsDBⁱ	59631

PTM databases

iPTMnetⁱ	Q13636
PhosphoSitePlusⁱ	Q13636

Expressionⁱ

Tissue specificityⁱ

Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000168461 Expressed in 236 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_RAB31
ExpressionAtlasⁱ	Q13636 baseline and differential
Genevisibleⁱ	Q13636 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019717

HPAⁱ

HPA019717

Interactionⁱ

Subunit structureⁱ

Interacts with OCRL. Interacts with NGFR (By similarity). Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts (in GTP-bound form) with EEA1. Interacts with EGFR.By similarity4 Publications

Protein-protein interaction databases

BioGridⁱ	116221, 32 interactors
IntActⁱ	Q13636, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q13636
STRINGⁱ	9606.ENSP00000304565

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	4 – 12	Combined sources	9
Helixⁱ	18 – 27	Combined sources	10
Beta strandⁱ	38 – 48	Combined sources	11
Beta strandⁱ	50 – 61	Combined sources	12
Helixⁱ	65 – 71	Combined sources	7
Helixⁱ	72 – 75	Combined sources	4
Beta strandⁱ	79 – 86	Combined sources	8
Helixⁱ	91 – 106	Combined sources	16
Beta strandⁱ	112 – 118	Combined sources	7
Helixⁱ	120 – 125	Combined sources	6
Helixⁱ	130 – 138	Combined sources	9
Turnⁱ	139 – 141	Combined sources	3
Beta strandⁱ	143 – 146	Combined sources	4
Turnⁱ	149 – 152	Combined sources	4
Helixⁱ	155 – 164	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13636
SMRⁱ	Q13636
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13636

EvolutionaryTraceⁱ

Q13636

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	34 – 42	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0092 Eukaryota ENOG410YCCP LUCA
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q13636
KEGG Orthology (KO) More...KOⁱ	K07891
OMAⁱ	QTGRRCC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HKN
PhylomeDBⁱ	Q13636
TreeFamⁱ	TF331262

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q13636-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAIRELKVCL LGDTGVGKSS IVCRFVQDHF DHNISPTIGA SFMTKTVPCG 
        60         70         80         90        100
NELHKFLIWD TAGQERFHSL APMYYRGSAA AVIVYDITKQ DSFYTLKKWV 
       110        120        130        140        150
KELKEHGPEN IVMAIAGNKC DLSDIREVPL KDAKEYAESI GAIVVETSAK 
       160        170        180        190 
NAINIEELFQ GISRQIPPLD PHENGNNGTI KVEKPTMQAS RRCC

Length:194

Mass (Da):21,569

Last modified:November 1, 1997 - v1

Checksum:ⁱ19825648A9C214B9

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3QR51	J3QR51_HUMAN	Ras-related protein Rab-31 Ras-related protein Rab-31	RAB31	74	Annotation score:
J3KSM8	J3KSM8_HUMAN	Ras-related protein Rab-31 Ras-related protein Rab-31	RAB31	59	Annotation score:
J3KRU3	J3KRU3_HUMAN	Ras-related protein Rab-31 Ras-related protein Rab-31	RAB31	25	Annotation score:

Sequence cautionⁱ

The sequence AAG09690 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH01148 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	189	A → S in AAC50773 (PubMed:8863739).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U57091 mRNA Translation: AAC50773.1 U59877 mRNA Translation: AAB02832.1 AF234995 mRNA Translation: AAG13847.1 AF183421 mRNA Translation: AAG09690.1 Different initiation. AF498957 mRNA Translation: AAM21105.1 AK314809 mRNA Translation: BAG37334.1 BT020027 mRNA Translation: AAV38830.1 BT020028 mRNA Translation: AAV38831.1 CR407659 mRNA Translation: CAG28587.1 AC006238 Genomic DNA No translation available. AP000902 Genomic DNA No translation available. BC001148 mRNA Translation: AAH01148.1 Different initiation.
PIRⁱ	JC4961
NCBI Reference Sequences More...RefSeqⁱ	NP_006859.2, NM_006868.3
UniGeneⁱ	Hs.744887 Hs.99528

Genome annotation databases

Ensemblⁱ	ENST00000578921; ENSP00000461945; ENSG00000168461
GeneIDⁱ	11031
KEGGⁱ	hsa:11031
UCSC genome browser More...UCSCⁱ	uc002kog.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13636	RAB31 isoform 1		PANTR		195	UniRef100_Q13636
RAB31, member RAS oncogene family		GORGO		195
RAB31, member RAS oncogene family		PANPA		183

Protein	Similar proteins		Species	Score	Length	Source
Q13636	Ras-related protein Rab-31		RAT		194	UniRef90_Q13636
Ras-related protein Rab-31		MOUSE		194
RAB31 isoform 1		PANTR		195
RAB31, member RAS oncogene family		GORGO		195
RAB31, member RAS oncogene family		PANPA		183
+27

Protein	Similar proteins		Species	Score	Length	Source
Q13636	Ras-related protein Rab-31		MOUSE		194	UniRef50_Q13636
Ras-related protein Rab-31		RAT		194
Ras-related protein Rab-22A		HUMAN		194
Ras-related protein Rab-22A		CANLF		194
RAB31 isoform 1		PANTR		195
+510

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U57091 mRNA Translation: AAC50773.1 U59877 mRNA Translation: AAB02832.1 AF234995 mRNA Translation: AAG13847.1 AF183421 mRNA Translation: AAG09690.1 Different initiation. AF498957 mRNA Translation: AAM21105.1 AK314809 mRNA Translation: BAG37334.1 BT020027 mRNA Translation: AAV38830.1 BT020028 mRNA Translation: AAV38831.1 CR407659 mRNA Translation: CAG28587.1 AC006238 Genomic DNA No translation available. AP000902 Genomic DNA No translation available. BC001148 mRNA Translation: AAH01148.1 Different initiation.
PIRⁱ	JC4961
RefSeqⁱ	NP_006859.2, NM_006868.3
UniGeneⁱ	Hs.744887 Hs.99528

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2FG5	X-ray	2.80	A	2-174	[»]
ProteinModelPortalⁱ	Q13636
SMRⁱ	Q13636
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116221, 32 interactors
IntActⁱ	Q13636, 7 interactors
MINTⁱ	Q13636
STRINGⁱ	9606.ENSP00000304565

PTM databases

iPTMnetⁱ	Q13636
PhosphoSitePlusⁱ	Q13636

Polymorphism and mutation databases

BioMutaⁱ	RAB31
DMDMⁱ	2500069

Proteomic databases

EPDⁱ	Q13636
MaxQBⁱ	Q13636
PaxDbⁱ	Q13636
PeptideAtlasⁱ	Q13636
PRIDEⁱ	Q13636
ProteomicsDBⁱ	59631

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11031
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000578921; ENSP00000461945; ENSG00000168461
GeneIDⁱ	11031
KEGGⁱ	hsa:11031
UCSCⁱ	uc002kog.3 human

Organism-specific databases

CTDⁱ	11031
DisGeNETⁱ	11031
EuPathDBⁱ	HostDB:ENSG00000168461.12
GeneCardsⁱ	RAB31
HGNCⁱ	HGNC:9771 RAB31
HPAⁱ	HPA019717
MIMⁱ	605694 gene
neXtProtⁱ	NX_Q13636
PharmGKBⁱ	PA34122
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0092 Eukaryota ENOG410YCCP LUCA
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q13636
KOⁱ	K07891
OMAⁱ	QTGRRCC
OrthoDBⁱ	EOG091G0HKN
PhylomeDBⁱ	Q13636
TreeFamⁱ	TF331262

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-8873719 RAB geranylgeranylation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSⁱ	RAB31 human
EvolutionaryTraceⁱ	Q13636
GeneWikiⁱ	RAB31
GenomeRNAiⁱ	11031
Protein Ontology More...PROⁱ	PR:Q13636
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168461 Expressed in 236 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_RAB31
ExpressionAtlasⁱ	Q13636 baseline and differential
Genevisibleⁱ	Q13636 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAB31_HUMAN
Accessionⁱ	Q13636Primary (citable) accession number: Q13636 Secondary accession number(s): B2RBT7, Q15770, Q9HC00
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q13636 (RAB31_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Ras-related protein Rab-31

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Golgi apparatus

Other locations

Cytosol

Endosome

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ