UniProtKB - Q13636 (RAB31_HUMAN)
Ras-related protein Rab-31
RAB31
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 19 | GTP | 8 | |
Nucleotide bindingi | 60 – 64 | GTP | 5 | |
Nucleotide bindingi | 118 – 121 | GTP | 4 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB
GO - Biological processi
- cellular response to insulin stimulus Source: UniProtKB
- Golgi to plasma membrane protein transport Source: UniProtKB
- intracellular protein transport Source: GO_Central
- neutrophil degranulation Source: Reactome
- phagosome maturation Source: UniProtKB
- positive regulation of phagocytosis, engulfment Source: UniProtKB
- receptor internalization Source: UniProtKB
- regulated exocytosis Source: UniProtKB
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q13636 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-8873719, RAB geranylgeranylation R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-31Alternative name(s): Ras-related protein Rab-22B |
Gene namesi | Name:RAB31 Synonyms:RAB22B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168461.12 |
HGNCi | HGNC:9771, RAB31 |
MIMi | 605694, gene |
neXtProti | NX_Q13636 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network 4 Publications
- trans-Golgi network membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Endosome
- Early endosome 2 Publications
Other locations
- phagosome 1 Publication
- phagosome membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Note: Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).1 Publication
Cytosol
- cytosol Source: Reactome
Endosome
- early endosome Source: UniProtKB
- early endosome membrane Source: Reactome
Golgi apparatus
- trans-Golgi network membrane Source: UniProtKB
Plasma Membrane
- phagocytic cup Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- early phagosome membrane Source: UniProtKB
- endomembrane system Source: GO_Central
- phagocytic vesicle Source: UniProtKB
- secretory granule membrane Source: Reactome
Keywords - Cellular componenti
Cytoplasmic vesicle, Endosome, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 64 | Q → L: No change in GTPase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 11031 |
PharmGKBi | PA34122 |
Miscellaneous databases
Pharosi | Q13636, Tbio |
Polymorphism and mutation databases
BioMutai | RAB31 |
DMDMi | 2500069 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121232 | 1 – 194 | Ras-related protein Rab-31Add BLAST | 194 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 35 | PhosphoserineCombined sources | 1 | |
Lipidationi | 193 | S-geranylgeranyl cysteineBy similarity | 1 | |
Lipidationi | 194 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Phosphoprotein, PrenylationProteomic databases
EPDi | Q13636 |
jPOSTi | Q13636 |
MassIVEi | Q13636 |
MaxQBi | Q13636 |
PaxDbi | Q13636 |
PeptideAtlasi | Q13636 |
PRIDEi | Q13636 |
ProteomicsDBi | 59631 |
PTM databases
iPTMneti | Q13636 |
PhosphoSitePlusi | Q13636 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000168461, Expressed in bone marrow and 248 other tissues |
ExpressionAtlasi | Q13636, baseline and differential |
Genevisiblei | Q13636, HS |
Organism-specific databases
HPAi | ENSG00000168461, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with OCRL.
Interacts with NGFR (By similarity).
Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF).
Interacts (in GTP-bound form) with EEA1.
Interacts with EGFR.
Interacts (in GTP-bound form) with APPL2; interaction contributes to or enhances recruitment of APPL2 to the phagosomes; interaction enhances Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity).
By similarity4 PublicationsBinary interactionsi
Q13636
With | #Exp. | IntAct |
---|---|---|
ALS2CL [Q60I27] | 3 | EBI-725987,EBI-12078276 |
Protein-protein interaction databases
BioGRIDi | 116221, 38 interactors |
IntActi | Q13636, 17 interactors |
MINTi | Q13636 |
STRINGi | 9606.ENSP00000461945 |
Miscellaneous databases
RNActi | Q13636, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13636 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13636 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 34 – 42 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0092, Eukaryota |
HOGENOMi | CLU_041217_10_2_1 |
InParanoidi | Q13636 |
OMAi | QTGRRCC |
OrthoDBi | 1340129at2759 |
PhylomeDBi | Q13636 |
TreeFami | TF331262 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAIRELKVCL LGDTGVGKSS IVCRFVQDHF DHNISPTIGA SFMTKTVPCG
60 70 80 90 100
NELHKFLIWD TAGQERFHSL APMYYRGSAA AVIVYDITKQ DSFYTLKKWV
110 120 130 140 150
KELKEHGPEN IVMAIAGNKC DLSDIREVPL KDAKEYAESI GAIVVETSAK
160 170 180 190
NAINIEELFQ GISRQIPPLD PHENGNNGTI KVEKPTMQAS RRCC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QR51 | J3QR51_HUMAN | Ras-related protein Rab-31 | RAB31 | 74 | Annotation score: | ||
J3KRU3 | J3KRU3_HUMAN | Ras-related protein Rab-31 | RAB31 | 25 | Annotation score: | ||
J3KSM8 | J3KSM8_HUMAN | Ras-related protein Rab-31 | RAB31 | 59 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 189 | A → S in AAC50773 (PubMed:8863739).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U57091 mRNA Translation: AAC50773.1 U59877 mRNA Translation: AAB02832.1 AF234995 mRNA Translation: AAG13847.1 AF183421 mRNA Translation: AAG09690.1 Different initiation. AF498957 mRNA Translation: AAM21105.1 AK314809 mRNA Translation: BAG37334.1 BT020027 mRNA Translation: AAV38830.1 BT020028 mRNA Translation: AAV38831.1 CR407659 mRNA Translation: CAG28587.1 AC006238 Genomic DNA No translation available. AP000902 Genomic DNA No translation available. BC001148 mRNA Translation: AAH01148.1 Different initiation. |
PIRi | JC4961 |
RefSeqi | NP_006859.2, NM_006868.3 |
Genome annotation databases
Ensembli | ENST00000578921; ENSP00000461945; ENSG00000168461 |
GeneIDi | 11031 |
KEGGi | hsa:11031 |
UCSCi | uc002kog.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U57091 mRNA Translation: AAC50773.1 U59877 mRNA Translation: AAB02832.1 AF234995 mRNA Translation: AAG13847.1 AF183421 mRNA Translation: AAG09690.1 Different initiation. AF498957 mRNA Translation: AAM21105.1 AK314809 mRNA Translation: BAG37334.1 BT020027 mRNA Translation: AAV38830.1 BT020028 mRNA Translation: AAV38831.1 CR407659 mRNA Translation: CAG28587.1 AC006238 Genomic DNA No translation available. AP000902 Genomic DNA No translation available. BC001148 mRNA Translation: AAH01148.1 Different initiation. |
PIRi | JC4961 |
RefSeqi | NP_006859.2, NM_006868.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FG5 | X-ray | 2.80 | A | 2-174 | [»] | |
SMRi | Q13636 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116221, 38 interactors |
IntActi | Q13636, 17 interactors |
MINTi | Q13636 |
STRINGi | 9606.ENSP00000461945 |
PTM databases
iPTMneti | Q13636 |
PhosphoSitePlusi | Q13636 |
Polymorphism and mutation databases
BioMutai | RAB31 |
DMDMi | 2500069 |
Proteomic databases
EPDi | Q13636 |
jPOSTi | Q13636 |
MassIVEi | Q13636 |
MaxQBi | Q13636 |
PaxDbi | Q13636 |
PeptideAtlasi | Q13636 |
PRIDEi | Q13636 |
ProteomicsDBi | 59631 |
Protocols and materials databases
Antibodypediai | 21931, 173 antibodies |
DNASUi | 11031 |
Genome annotation databases
Ensembli | ENST00000578921; ENSP00000461945; ENSG00000168461 |
GeneIDi | 11031 |
KEGGi | hsa:11031 |
UCSCi | uc002kog.3, human |
Organism-specific databases
CTDi | 11031 |
DisGeNETi | 11031 |
EuPathDBi | HostDB:ENSG00000168461.12 |
GeneCardsi | RAB31 |
HGNCi | HGNC:9771, RAB31 |
HPAi | ENSG00000168461, Low tissue specificity |
MIMi | 605694, gene |
neXtProti | NX_Q13636 |
PharmGKBi | PA34122 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0092, Eukaryota |
HOGENOMi | CLU_041217_10_2_1 |
InParanoidi | Q13636 |
OMAi | QTGRRCC |
OrthoDBi | 1340129at2759 |
PhylomeDBi | Q13636 |
TreeFami | TF331262 |
Enzyme and pathway databases
PathwayCommonsi | Q13636 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-8873719, RAB geranylgeranylation R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
BioGRID-ORCSi | 11031, 3 hits in 840 CRISPR screens |
ChiTaRSi | RAB31, human |
EvolutionaryTracei | Q13636 |
GeneWikii | RAB31 |
GenomeRNAii | 11031 |
Pharosi | Q13636, Tbio |
PROi | PR:Q13636 |
RNActi | Q13636, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168461, Expressed in bone marrow and 248 other tissues |
ExpressionAtlasi | Q13636, baseline and differential |
Genevisiblei | Q13636, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB31_HUMAN | |
Accessioni | Q13636Primary (citable) accession number: Q13636 Secondary accession number(s): B2RBT7, Q15770, Q9HC00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM