Protein patched homolog 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cholesterol binding Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The hedgehog receptor patched is involved in cholesterol transport."
    Bidet M., Joubert O., Lacombe B., Ciantar M., Nehme R., Mollat P., Bretillon L., Faure H., Bittman R., Ruat M., Mus-Veteau I.
    PLoS ONE 6:e23834-e23834(2011) [PubMed] [Europe PMC] [Abstract]
• cyclin binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Patched1 interacts with cyclin B1 to regulate cell cycle progression."
    Barnes E.A., Kong M., Ollendorff V., Donoghue D.J.
    EMBO J. 20:2214-2223(2001) [PubMed] [Europe PMC] [Abstract]
• hedgehog family protein binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Characterization of two patched receptors for the vertebrate hedgehog protein family."
    Carpenter D., Stone D.M., Brush J., Ryan A., Armanini M., Frantz G., Rosenthal A., de Sauvage F.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:13630-13634(1998) [PubMed] [Europe PMC] [Abstract]
• hedgehog receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• heparin binding Source: Ensembl
• patched binding Source: Ensembl
• protein-containing complex binding Source: Ensembl
• smoothened binding Source: BHF-UCLInferred from physical interactionⁱ
  • "The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane."
    Karpen H.E., Bukowski J.T., Hughes T., Gratton J.P., Sessa W.C., Gailani M.R.
    J. Biol. Chem. 276:19503-19511(2001) [PubMed] [Europe PMC] [Abstract]
  • "Characterization of two patched receptors for the vertebrate hedgehog protein family."
    Carpenter D., Stone D.M., Brush J., Ryan A., Armanini M., Frantz G., Rosenthal A., de Sauvage F.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:13630-13634(1998) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• animal organ morphogenesis Source: UniProtKB
• brain development Source: BHF-UCL
• branching involved in ureteric bud morphogenesis Source: Ensembl
• cell differentiation involved in kidney development Source: Ensembl
• cell fate determination Source: Ensembl
• cell proliferation involved in metanephros development Source: Ensembl
• cellular response to cholesterol Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane."
    Karpen H.E., Bukowski J.T., Hughes T., Gratton J.P., Sessa W.C., Gailani M.R.
    J. Biol. Chem. 276:19503-19511(2001) [PubMed] [Europe PMC] [Abstract]
• commissural neuron axon guidance Source: Ensembl
• dorsal/ventral pattern formation Source: UniProtKB
• embryonic limb morphogenesis Source: UniProtKB
• embryonic organ development Source: Ensembl
• epidermal cell fate specification Source: Ensembl
• glucose homeostasis Source: Ensembl
• heart morphogenesis Source: Ensembl
• hindlimb morphogenesis Source: Ensembl
• in utero embryonic development Source: Ensembl
• keratinocyte proliferation Source: Ensembl
• limb morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome."
    Hahn H., Wicking C., Zaphiropoulous P.G., Gailani M.R., Shanley S., Chidambaram A., Vorechovsky I., Holmberg E., Unden A.B., Gillies S., Negus K., Smyth I., Pressman C., Leffell D.J., Gerrard B., Goldstein A.M., Dean M., Toftgard R.

    , Chenevix-Trench G., Wainwright B., Bale A.E.
    Cell 85:841-851(1996) [PubMed] [Europe PMC] [Abstract]
• liver regeneration Source: Ensembl
• mammary gland duct morphogenesis Source: Ensembl
• mammary gland epithelial cell differentiation Source: Ensembl
• metanephric collecting duct development Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development."
    Jenkins D., Winyard P.J., Woolf A.S.
    J. Anat. 211:620-629(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell division Source: Ensembl
• negative regulation of DNA-binding transcription factor activity Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Inhibition of GLI1 gene activation by Patched1."
    Rahnama F., Shimokawa T., Lauth M., Finta C., Kogerman P., Teglund S., Toftgard R., Zaphiropoulos P.G.
    Biochem. J. 394:19-26(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial cell proliferation Source: Ensembl
• negative regulation of multicellular organism growth Source: UniProtKB
• negative regulation of osteoblast differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Inhibition of GLI1 gene activation by Patched1."
    Rahnama F., Shimokawa T., Lauth M., Finta C., Kogerman P., Teglund S., Toftgard R., Zaphiropoulos P.G.
    Biochem. J. 394:19-26(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of smoothened signaling pathway Source: BHF-UCL
• negative regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Inhibition of GLI1 gene activation by Patched1."
    Rahnama F., Shimokawa T., Lauth M., Finta C., Kogerman P., Teglund S., Toftgard R., Zaphiropoulos P.G.
    Biochem. J. 394:19-26(2006) [PubMed] [Europe PMC] [Abstract]
• neural plate axis specification Source: BHF-UCL
• neural tube closure Source: Ensembl
• neural tube patterning Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome."
    Hahn H., Wicking C., Zaphiropoulous P.G., Gailani M.R., Shanley S., Chidambaram A., Vorechovsky I., Holmberg E., Unden A.B., Gillies S., Negus K., Smyth I., Pressman C., Leffell D.J., Gerrard B., Goldstein A.M., Dean M., Toftgard R.

    , Chenevix-Trench G., Wainwright B., Bale A.E.
    Cell 85:841-851(1996) [PubMed] [Europe PMC] [Abstract]
• pharyngeal system development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome."
    Hahn H., Wicking C., Zaphiropoulous P.G., Gailani M.R., Shanley S., Chidambaram A., Vorechovsky I., Holmberg E., Unden A.B., Gillies S., Negus K., Smyth I., Pressman C., Leffell D.J., Gerrard B., Goldstein A.M., Dean M., Toftgard R.

    , Chenevix-Trench G., Wainwright B., Bale A.E.
    Cell 85:841-851(1996) [PubMed] [Europe PMC] [Abstract]
  • Ref.10

    "Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident."
    Wicking C., Shanley S., Smyth I., Gillies S., Negus K., Graham S., Suthers G., Haites N., Edwards M., Wainwright B.J., Chenevix-Trench G.
    Am. J. Hum. Genet. 60:21-26(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANTS BCNS TYR-513 AND ARG-1069.
• positive regulation of cholesterol efflux Source: BHF-UCLInferred from direct assayⁱ
  • "The hedgehog receptor patched is involved in cholesterol transport."
    Bidet M., Joubert O., Lacombe B., Ciantar M., Nehme R., Mollat P., Bretillon L., Faure H., Bittman R., Ruat M., Mus-Veteau I.
    PLoS ONE 6:e23834-e23834(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epidermal cell differentiation Source: Ensembl
• positive regulation of transcription, DNA-templated Source: Ensembl
• prostate gland development Source: Ensembl
• protein localization to plasma membrane Source: BHF-UCLInferred from direct assayⁱ
  • "The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane."
    Karpen H.E., Bukowski J.T., Hughes T., Gratton J.P., Sessa W.C., Gailani M.R.
    J. Biol. Chem. 276:19503-19511(2001) [PubMed] [Europe PMC] [Abstract]
• protein processing Source: UniProtKB
• regulation of mitotic cell cycle Source: Ensembl
• regulation of protein localization Source: Ensembl
• regulation of smoothened signaling pathway Source: UniProtKB
• response to chlorate Source: Ensembl
• response to drug Source: Ensembl
• response to estradiol Source: Ensembl
• response to mechanical stimulus Source: Ensembl
• response to retinoic acid Source: Ensembl
• smoothened signaling pathway Source: UniProtKBInferred from expression patternⁱ
  • "Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development."
    Jenkins D., Winyard P.J., Woolf A.S.
    J. Anat. 211:620-629(2007) [PubMed] [Europe PMC] [Abstract]
• smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: Ensembl
• smooth muscle tissue development Source: UniProtKBInferred from expression patternⁱ
  • "Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development."
    Jenkins D., Winyard P.J., Woolf A.S.
    J. Anat. 211:620-629(2007) [PubMed] [Europe PMC] [Abstract]
• somite development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome."
    Hahn H., Wicking C., Zaphiropoulous P.G., Gailani M.R., Shanley S., Chidambaram A., Vorechovsky I., Holmberg E., Unden A.B., Gillies S., Negus K., Smyth I., Pressman C., Leffell D.J., Gerrard B., Goldstein A.M., Dean M., Toftgard R.

    , Chenevix-Trench G., Wainwright B., Bale A.E.
    Cell 85:841-851(1996) [PubMed] [Europe PMC] [Abstract]
• spinal cord motor neuron differentiation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• cyclin binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Patched1 interacts with cyclin B1 to regulate cell cycle progression."
    Barnes E.A., Kong M., Ollendorff V., Donoghue D.J.
    EMBO J. 20:2214-2223(2001) [PubMed] [Europe PMC] [Abstract]
• hedgehog family protein binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Characterization of two patched receptors for the vertebrate hedgehog protein family."
    Carpenter D., Stone D.M., Brush J., Ryan A., Armanini M., Frantz G., Rosenthal A., de Sauvage F.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:13630-13634(1998) [PubMed] [Europe PMC] [Abstract]
• patched binding Source: Ensembl
• smoothened binding Source: BHF-UCLInferred from physical interactionⁱ
  • "The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane."
    Karpen H.E., Bukowski J.T., Hughes T., Gratton J.P., Sessa W.C., Gailani M.R.
    J. Biol. Chem. 276:19503-19511(2001) [PubMed] [Europe PMC] [Abstract]
  • "Characterization of two patched receptors for the vertebrate hedgehog protein family."
    Carpenter D., Stone D.M., Brush J., Ryan A., Armanini M., Frantz G., Rosenthal A., de Sauvage F.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:13630-13634(1998) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MASAGNAAEP QDRGGGGSGC IGAPGRPAGG GRRRRTGGLR RAAAPDRDYL 
        60         70         80         90        100
HRPSYCDAAF ALEQISKGKA TGRKAPLWLR AKFQRLLFKL GCYIQKNCGK 
       110        120        130        140        150
FLVVGLLIFG AFAVGLKAAN LETNVEELWV EVGGRVSREL NYTRQKIGEE 
       160        170        180        190        200
AMFNPQLMIQ TPKEEGANVL TTEALLQHLD SALQASRVHV YMYNRQWKLE 
       210        220        230        240        250
HLCYKSGELI TETGYMDQII EYLYPCLIIT PLDCFWEGAK LQSGTAYLLG 
       260        270        280        290        300
KPPLRWTNFD PLEFLEELKK INYQVDSWEE MLNKAEVGHG YMDRPCLNPA 
       310        320        330        340        350
DPDCPATAPN KNSTKPLDMA LVLNGGCHGL SRKYMHWQEE LIVGGTVKNS 
       360        370        380        390        400
TGKLVSAHAL QTMFQLMTPK QMYEHFKGYE YVSHINWNED KAAAILEAWQ 
       410        420        430        440        450
RTYVEVVHQS VAQNSTQKVL SFTTTTLDDI LKSFSDVSVI RVASGYLLML 
       460        470        480        490        500
AYACLTMLRW DCSKSQGAVG LAGVLLVALS VAAGLGLCSL IGISFNAATT 
       510        520        530        540        550
QVLPFLALGV GVDDVFLLAH AFSETGQNKR IPFEDRTGEC LKRTGASVAL 
       560        570        580        590        600
TSISNVTAFF MAALIPIPAL RAFSLQAAVV VVFNFAMVLL IFPAILSMDL 
       610        620        630        640        650
YRREDRRLDI FCCFTSPCVS RVIQVEPQAY TDTHDNTRYS PPPPYSSHSF 
       660        670        680        690        700
AHETQITMQS TVQLRTEYDP HTHVYYTTAE PRSEISVQPV TVTQDTLSCQ 
       710        720        730        740        750
SPESTSSTRD LLSQFSDSSL HCLEPPCTKW TLSSFAEKHY APFLLKPKAK 
       760        770        780        790        800
VVVIFLFLGL LGVSLYGTTR VRDGLDLTDI VPRETREYDF IAAQFKYFSF 
       810        820        830        840        850
YNMYIVTQKA DYPNIQHLLY DLHRSFSNVK YVMLEENKQL PKMWLHYFRD 
       860        870        880        890        900
WLQGLQDAFD SDWETGKIMP NNYKNGSDDG VLAYKLLVQT GSRDKPIDIS 
       910        920        930        940        950
QLTKQRLVDA DGIINPSAFY IYLTAWVSND PVAYAASQAN IRPHRPEWVH 
       960        970        980        990       1000
DKADYMPETR LRIPAAEPIE YAQFPFYLNG LRDTSDFVEA IEKVRTICSN 
      1010       1020       1030       1040       1050
YTSLGLSSYP NGYPFLFWEQ YIGLRHWLLL FISVVLACTF LVCAVFLLNP 
      1060       1070       1080       1090       1100
WTAGIIVMVL ALMTVELFGM MGLIGIKLSA VPVVILIASV GIGVEFTVHV 
      1110       1120       1130       1140       1150
ALAFLTAIGD KNRRAVLALE HMFAPVLDGA VSTLLGVLML AGSEFDFIVR 
      1160       1170       1180       1190       1200
YFFAVLAILT ILGVLNGLVL LPVLLSFFGP YPEVSPANGL NRLPTPSPEP 
      1210       1220       1230       1240       1250
PPSVVRFAMP PGHTHSGSDS SDSEYSSQTT VSGLSEELRH YEAQQGAGGP 
      1260       1270       1280       1290       1300
AHQVIVEATE NPVFAHSTVV HPESRHHPPS NPRQQPHLDS GSLPPGRQGQ 
      1310       1320       1330       1340       1350
QPRRDPPREG LWPPPYRPRR DAFEISTEGH SGPSNRARWG PRGARSHNPR 
      1360       1370       1380       1390       1400
NPASTAMGSS VPGYCQPITT VTASASVTVA VHPPPVPGPG RNPRGGLCPG 
      1410       1420       1430       1440 
YPETDHGLFE DPHVPFHVRC ERRDSKVEVI ELQDVECEER PRGSSSN    

        10         20         30         40         50
MELLNRNRLV IVSPRCTPPK ASGGPARRGF YTFRSFCKDG GGGEEEEENG 
        60         70         80         90        100
GEEKDDRGDK ETRSDKGKAT GRKAPLWLRA KFQRLLFKLG CYIQKNCGKF 
       110        120        130        140        150
LVVGLLIFGA FAVGLKAANL ETNVEELWVE VGGRVSRELN YTRQKIGEEA 
       160        170        180        190        200
MFNPQLMIQT PKEEGANVLT TEALLQHLDS ALQASRVHVY MYNRQWKLEH 
       210        220        230        240        250
LCYKSGELIT ETGYMDQIIE YLYPCLIITP LDCFWEGAKL QSGTAYLLGK 
       260        270        280        290        300
PPLRWTNFDP LEFLEELKKI NYQVDSWEEM LNKAEVGHGY MDRPCLNPAD 
       310        320        330        340        350
PDCPATAPNK NSTKPLDMAL VLNGGCHGLS RKYMHWQEEL IVGGTVKNST 
       360        370        380        390        400
GKLVSAHALQ TMFQLMTPKQ MYEHFKGYEY VSHINWNEDK AAAILEAWQR 
       410        420        430        440        450
TYVEVVHQSV AQNSTQKVLS FTTTTLDDIL KSFSDVSVIR VASGYLLMLA 
       460        470        480        490        500
YACLTMLRWD CSKSQGAVGL AGVLLVALSV AAGLGLCSLI GISFNAATTQ 
       510        520        530        540        550
VLPFLALGVG VDDVFLLAHA FSETGQNKRI PFEDRTGECL KRTGASVALT 
       560        570        580        590        600
SISNVTAFFM AALIPIPALR AFSLQAAVVV VFNFAMVLLI FPAILSMDLY 
       610        620        630        640        650
RREDRRLDIF CCFTSPCVSR VIQVEPQAYT DTHDNTRYSP PPPYSSHSFA 
       660        670        680        690        700
HETQITMQST VQLRTEYDPH THVYYTTAEP RSEISVQPVT VTQDTLSCQS 
       710        720        730        740        750
PESTSSTRDL LSQFSDSSLH CLEPPCTKWT LSSFAEKHYA PFLLKPKAKV 
       760        770        780        790        800
VVIFLFLGLL GVSLYGTTRV RDGLDLTDIV PRETREYDFI AAQFKYFSFY 
       810        820        830        840        850
NMYIVTQKAD YPNIQHLLYD LHRSFSNVKY VMLEENKQLP KMWLHYFRDW 
       860        870        880        890        900
LQGLQDAFDS DWETGKIMPN NYKNGSDDGV LAYKLLVQTG SRDKPIDISQ 
       910        920        930        940        950
LTKQRLVDAD GIINPSAFYI YLTAWVSNDP VAYAASQANI RPHRPEWVHD 
       960        970        980        990       1000
KADYMPETRL RIPAAEPIEY AQFPFYLNGL RDTSDFVEAI EKVRTICSNY 
      1010       1020       1030       1040       1050
TSLGLSSYPN GYPFLFWEQY IGLRHWLLLF ISVVLACTFL VCAVFLLNPW 
      1060       1070       1080       1090       1100
TAGIIVMVLA LMTVELFGMM GLIGIKLSAV PVVILIASVG IGVEFTVHVA 
      1110       1120       1130       1140       1150
LAFLTAIGDK NRRAVLALEH MFAPVLDGAV STLLGVLMLA GSEFDFIVRY 
      1160       1170       1180       1190       1200
FFAVLAILTI LGVLNGLVLL PVLLSFFGPY PEVSPANGLN RLPTPSPEPP 
      1210       1220       1230       1240       1250
PSVVRFAMPP GHTHSGSDSS DSEYSSQTTV SGLSEELRHY EAQQGAGGPA 
      1260       1270       1280       1290       1300
HQVIVEATEN PVFAHSTVVH PESRHHPPSN PRQQPHLDSG SLPPGRQGQQ 
      1310       1320       1330       1340       1350
PRRDPPREGL WPPPYRPRRD AFEISTEGHS GPSNRARWGP RGARSHNPRN 
      1360       1370       1380       1390       1400
PASTAMGSSV PGYCQPITTV TASASVTVAV HPPPVPGPGR NPRGGLCPGY 
      1410       1420       1430       1440 
PETDHGLFED PHVPFHVRCE RRDSKVEVIE LQDVECEERP RGSSSN     

        10         20         30         40         50
MGKATGRKAP LWLRAKFQRL LFKLGCYIQK NCGKFLVVGL LIFGAFAVGL 
        60         70         80         90        100
KAANLETNVE ELWVEVGGRV SRELNYTRQK IGEEAMFNPQ LMIQTPKEEG 
       110        120        130        140        150
ANVLTTEALL QHLDSALQAS RVHVYMYNRQ WKLEHLCYKS GELITETGYM 
       160        170        180        190        200
DQIIEYLYPC LIITPLDCFW EGAKLQSGTA YLLGKPPLRW TNFDPLEFLE 
       210        220        230        240        250
ELKKINYQVD SWEEMLNKAE VGHGYMDRPC LNPADPDCPA TAPNKNSTKP 
       260        270        280        290        300
LDMALVLNGG CHGLSRKYMH WQEELIVGGT VKNSTGKLVS AHALQTMFQL 
       310        320        330        340        350
MTPKQMYEHF KGYEYVSHIN WNEDKAAAIL EAWQRTYVEV VHQSVAQNST 
       360        370        380        390        400
QKVLSFTTTT LDDILKSFSD VSVIRVASGY LLMLAYACLT MLRWDCSKSQ 
       410        420        430        440        450
GAVGLAGVLL VALSVAAGLG LCSLIGISFN AATTQVLPFL ALGVGVDDVF 
       460        470        480        490        500
LLAHAFSETG QNKRIPFEDR TGECLKRTGA SVALTSISNV TAFFMAALIP 
       510        520        530        540        550
IPALRAFSLQ AAVVVVFNFA MVLLIFPAIL SMDLYRREDR RLDIFCCFTS 
       560        570        580        590        600
PCVSRVIQVE PQAYTDTHDN TRYSPPPPYS SHSFAHETQI TMQSTVQLRT 
       610        620        630        640        650
EYDPHTHVYY TTAEPRSEIS VQPVTVTQDT LSCQSPESTS STRDLLSQFS 
       660        670        680        690        700
DSSLHCLEPP CTKWTLSSFA EKHYAPFLLK PKAKVVVIFL FLGLLGVSLY 
       710        720        730        740        750
GTTRVRDGLD LTDIVPRETR EYDFIAAQFK YFSFYNMYIV TQKADYPNIQ 
       760        770        780        790        800
HLLYDLHRSF SNVKYVMLEE NKQLPKMWLH YFRDWLQGLQ DAFDSDWETG 
       810        820        830        840        850
KIMPNNYKNG SDDGVLAYKL LVQTGSRDKP IDISQLTKQR LVDADGIINP 
       860        870        880        890        900
SAFYIYLTAW VSNDPVAYAA SQANIRPHRP EWVHDKADYM PETRLRIPAA 
       910        920        930        940        950
EPIEYAQFPF YLNGLRDTSD FVEAIEKVRT ICSNYTSLGL SSYPNGYPFL 
       960        970        980        990       1000
FWEQYIGLRH WLLLFISVVL ACTFLVCAVF LLNPWTAGII VMVLALMTVE 
      1010       1020       1030       1040       1050
LFGMMGLIGI KLSAVPVVIL IASVGIGVEF TVHVALAFLT AIGDKNRRAV 
      1060       1070       1080       1090       1100
LALEHMFAPV LDGAVSTLLG VLMLAGSEFD FIVRYFFAVL AILTILGVLN 
      1110       1120       1130       1140       1150
GLVLLPVLLS FFGPYPEVSP ANGLNRLPTP SPEPPPSVVR FAMPPGHTHS 
      1160       1170       1180       1190       1200
GSDSSDSEYS SQTTVSGLSE ELRHYEAQQG AGGPAHQVIV EATENPVFAH 
      1210       1220       1230       1240       1250
STVVHPESRH HPPSNPRQQP HLDSGSLPPG RQGQQPRRDP PREGLWPPPY 
      1260       1270       1280       1290       1300
RPRRDAFEIS TEGHSGPSNR ARWGPRGARS HNPRNPASTA MGSSVPGYCQ 
      1310       1320       1330       1340       1350
PITTVTASAS VTVAVHPPPV PGPGRNPRGG LCPGYPETDH GLFEDPHVPF 
      1360       1370       1380 
HVRCERRDSK VEVIELQDVE CEERPRGSSS N                     

        10         20         30         40         50
MFNPQLMIQT PKEEGANVLT TEALLQHLDS ALQASRVHVY MYNRQWKLEH 
        60         70         80         90        100
LCYKSGELIT ETGYMDQIIE YLYPCLIITP LDCFWEGAKL QSGTAYLLGK 
       110        120        130        140        150
PPLRWTNFDP LEFLEELKKI NYQVDSWEEM LNKAEVGHGY MDRPCLNPAD 
       160        170        180        190        200
PDCPATAPNK NSTKPLDMAL VLNGGCHGLS RKYMHWQEEL IVGGTVKNST 
       210        220        230        240        250
GKLVSAHALQ TMFQLMTPKQ MYEHFKGYEY VSHINWNEDK AAAILEAWQR 
       260        270        280        290        300
TYVEVVHQSV AQNSTQKVLS FTTTTLDDIL KSFSDVSVIR VASGYLLMLA 
       310        320        330        340        350
YACLTMLRWD CSKSQGAVGL AGVLLVALSV AAGLGLCSLI GISFNAATTQ 
       360        370        380        390        400
VLPFLALGVG VDDVFLLAHA FSETGQNKRI PFEDRTGECL KRTGASVALT 
       410        420        430        440        450
SISNVTAFFM AALIPIPALR AFSLQAAVVV VFNFAMVLLI FPAILSMDLY 
       460        470        480        490        500
RREDRRLDIF CCFTSPCVSR VIQVEPQAYT DTHDNTRYSP PPPYSSHSFA 
       510        520        530        540        550
HETQITMQST VQLRTEYDPH THVYYTTAEP RSEISVQPVT VTQDTLSCQS 
       560        570        580        590        600
PESTSSTRDL LSQFSDSSLH CLEPPCTKWT LSSFAEKHYA PFLLKPKAKV 
       610        620        630        640        650
VVIFLFLGLL GVSLYGTTRV RDGLDLTDIV PRETREYDFI AAQFKYFSFY 
       660        670        680        690        700
NMYIVTQKAD YPNIQHLLYD LHRSFSNVKY VMLEENKQLP KMWLHYFRDW 
       710        720        730        740        750
LQGLQDAFDS DWETGKIMPN NYKNGSDDGV LAYKLLVQTG SRDKPIDISQ 
       760        770        780        790        800
LTKQRLVDAD GIINPSAFYI YLTAWVSNDP VAYAASQANI RPHRPEWVHD 
       810        820        830        840        850
KADYMPETRL RIPAAEPIEY AQFPFYLNGL RDTSDFVEAI EKVRTICSNY 
       860        870        880        890        900
TSLGLSSYPN GYPFLFWEQY IGLRHWLLLF ISVVLACTFL VCAVFLLNPW 
       910        920        930        940        950
TAGIIVMVLA LMTVELFGMM GLIGIKLSAV PVVILIASVG IGVEFTVHVA 
       960        970        980        990       1000
LAFLTAIGDK NRRAVLALEH MFAPVLDGAV STLLGVLMLA GSEFDFIVRY 
      1010       1020       1030       1040       1050
FFAVLAILTI LGVLNGLVLL PVLLSFFGPY PEVSPANGLN RLPTPSPEPP 
      1060       1070       1080       1090       1100
PSVVRFAMPP GHTHSGSDSS DSEYSSQTTV SGLSEELRHY EAQQGAGGPA 
      1110       1120       1130       1140       1150
HQVIVEATEN PVFAHSTVVH PESRHHPPSN PRQQPHLDSG SLPPGRQGQQ 
      1160       1170       1180       1190       1200
PRRDPPREGL WPPPYRPRRD AFEISTEGHS GPSNRARWGP RGARSHNPRN 
      1210       1220       1230       1240       1250
PASTAMGSSV PGYCQPITTV TASASVTVAV HPPPVPGPGR NPRGGLCPGY 
      1260       1270       1280       1290 
PETDHGLFED PHVPFHVRCE RRDSKVEVIE LQDVECEERP RGSSSN     

Experimental Info

Natural variant