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Entry version 205 (16 Oct 2019)
Sequence version 2 (15 Jul 1998)
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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Gene

DYRK1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by RANBP9 (PubMed:14500717). Inhibited by harmine, leucettamine B and leucettine L41 (PubMed:22998443).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei188ATPCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei287Proton acceptor1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi165 – 173ATPCurated9
Nucleotide bindingi238 – 241ATPCurated4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.12.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1538133 G0 and Early G1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q13627

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13627

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC:2.7.12.14 Publications)
Alternative name(s):
Dual specificity YAK1-related kinase
HP86
Protein kinase minibrain homolog
Short name:
MNBH
Short name:
hMNB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DYRK1A
Synonyms:DYRK, MNB, MNBH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3091 DYRK1A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600855 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13627

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal dominant 7 (MRD7)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi188K → R: Abolishes kinase activity. 1 Publication1
Mutagenesisi321Y → F: Mildly reduces kinase activity. Does not abolish autophosphorylation on tyrosine residues. 1 Publication1

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1859

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
DYRK1A

MalaCards human disease database

More...
MalaCardsi
DYRK1A
MIMi614104 phenotype

Open Targets

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OpenTargetsi
ENSG00000157540

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
268261 DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion
464311 Intellectual disability syndrome due to a DYRK1A point mutation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27545

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13627

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2292

Drug and drug target database

More...
DrugBanki
DB12010 Fostamatinib
DB07608 N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide

DrugCentral

More...
DrugCentrali
Q13627

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2009

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DYRK1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3219996

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000859311 – 763Dual specificity tyrosine-phosphorylation-regulated kinase 1AAdd BLAST763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei111Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei140Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei145PhosphotyrosineCombined sources1
Modified residuei159Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei177Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei219Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei310Phosphoserine; by autocatalysis1 Publication1
Modified residuei319Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei321Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei402Phosphothreonine; by autocatalysis1 Publication1
Modified residuei449Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei529PhosphoserineCombined sources1
Modified residuei538PhosphoserineBy similarity1
Modified residuei748PhosphoserineCombined sources1
Modified residuei758PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13627

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13627

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13627

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13627

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13627

PeptideAtlas

More...
PeptideAtlasi
Q13627

PRoteomics IDEntifications database

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PRIDEi
Q13627

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
59619 [Q13627-1]
59620 [Q13627-2]
59621 [Q13627-3]
59622 [Q13627-4]
59623 [Q13627-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13627

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13627

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157540 Expressed in 238 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13627 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13627 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015323
HPA015810

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts RAD54L2/ARIP4 (By similarity). Interacts with CRY2 (By similarity).

Interacts with RANBP9 (PubMed:14500717).

Interacts with WDR68 (PubMed:14593110).

Interacts with SRSF6 (PubMed:22767602).

Interacts with SIRT1 (By similarity).

By similarity4 Publications

(Microbial infection) Interacts with human adenovirus 5 E1A protein (PubMed:23864635).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108192, 85 interactors

Database of interacting proteins

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DIPi
DIP-39750N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q13627

Protein interaction database and analysis system

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IntActi
Q13627, 44 interactors

Molecular INTeraction database

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MINTi
Q13627

STRING: functional protein association networks

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STRINGi
9606.ENSP00000381932

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q13627

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1763
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13627

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q13627

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini159 – 479Protein kinasePROSITE-ProRule annotationAdd BLAST321

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi117 – 134Bipartite nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi509 – 515Poly-Ser7
Compositional biasi599 – 602Poly-His4
Compositional biasi607 – 619Poly-HisAdd BLAST13
Compositional biasi656 – 672Ser/Thr-richAdd BLAST17
Compositional biasi664 – 671Poly-Ser8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The polyhistidine repeats act as targeting signals to nuclear speckles.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0667 Eukaryota
ENOG410XPET LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157408

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000220863

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13627

KEGG Orthology (KO)

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KOi
K08825

Identification of Orthologs from Complete Genome Data

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OMAi
PAYQFSA

Database of Orthologous Groups

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OrthoDBi
271572at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13627

TreeFam database of animal gene trees

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TreeFami
TF314624

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028318 DYRK1A/B_MNB
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

The PANTHER Classification System

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PANTHERi
PTHR24058:SF12 PTHR24058:SF12, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q13627-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD
60 70 80 90 100
QQVSALSYSD QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL
110 120 130 140 150
IKTYKHINEV YYAKKKRRHQ QGQGDDSSHK KERKVYNDGY DDDNYDYIVK
160 170 180 190 200
NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV EQEWVAIKII KNKKAFLNQA
210 220 230 240 250
QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM LSYNLYDLLR
260 270 280 290 300
NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR
310 320 330 340 350
SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI
360 370 380 390 400
LVEMHTGEPL FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD
410 420 430 440 450
GTWNLKKTKD GKREYKPPGT RKLHNILGVE TGGPGGRRAG ESGHTVADYL
460 470 480 490 500
KFKDLILRML DYDPKTRIQP YYALQHSFFK KTADEGTNTS NSVSTSPAME
510 520 530 540 550
QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG HFTAAVQAMD
560 570 580 590 600
CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH
610 620 630 640 650
HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH
660 670 680 690 700
SHHSMTSLSS STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV
710 720 730 740 750
NLTVYSNPRQ ETGIAGHPTY QFSANTGPAH YMTEGHLTMR QGADREESPM
760
TGVCVQQSPV ASS
Length:763
Mass (Da):85,584
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C3A52A3CBB04FB5
GO
Isoform 1 (identifier: Q13627-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-78: Missing.

Show »
Length:754
Mass (Da):84,556
Checksum:i59518E25F1D4FF96
GO
Isoform 2 (identifier: Q13627-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-529: GGSSGTSNSGRARS → GASAISCSSWLVRH
     530-763: Missing.

Show »
Length:529
Mass (Da):60,330
Checksum:iF639B3152ACC7750
GO
Isoform 3 (identifier: Q13627-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: GGSSGTSNSG → GGAALDARCL
     526-763: Missing.

Show »
Length:525
Mass (Da):59,802
Checksum:i331976E38527AA3F
GO
Isoform 4 (identifier: Q13627-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     559-584: RQQFPAPLGWSGTEAPTQVTVETHPV → SSHVVHLLVSPAILRWSSTGCQVPLE
     585-763: Missing.

Show »
Length:584
Mass (Da):66,099
Checksum:iBA2480B34BAB2878
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y443A0A2R8Y443_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
400Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6I6A0A2R8Y6I6_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
725Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6L5A0A2R8Y6L5_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
605Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDF3A0A2R8YDF3_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
519Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
N0GVR9N0GVR9_HUMAN
Dual-specificity tyrosine-(Y)-phosp...
DYRK1A DYRK1A_var1, DYRK1A_var2
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMI5E7EMI5_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEY4A0A2R8YEY4_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32G → A in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti47N → S in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti57S → P in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti123Q → R in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti266A → V in CAA05059 (PubMed:9503011).Curated1
Sequence conflicti357G → R in CAA05059 (PubMed:9503011).Curated1
Sequence conflicti397K → N in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti592A → G in AAC50939 (PubMed:8975710).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_009395415Y → F1 Publication1
Natural variantiVAR_040453679A → P2 PublicationsCorresponds to variant dbSNP:rs55720916Ensembl.1
Natural variantiVAR_009396681Q → H1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00491770 – 78Missing in isoform 1. 2 Publications9
Alternative sequenceiVSP_004918516 – 529GGSSG…GRARS → GASAISCSSWLVRH in isoform 2. CuratedAdd BLAST14
Alternative sequenceiVSP_004920516 – 525GGSSGTSNSG → GGAALDARCL in isoform 3. Curated10
Alternative sequenceiVSP_004921526 – 763Missing in isoform 3. CuratedAdd BLAST238
Alternative sequenceiVSP_004919530 – 763Missing in isoform 2. CuratedAdd BLAST234
Alternative sequenceiVSP_004922559 – 584RQQFP…ETHPV → SSHVVHLLVSPAILRWSSTG CQVPLE in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_004923585 – 763Missing in isoform 4. 1 PublicationAdd BLAST179

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U58496 mRNA Translation: AAC50939.1
U52373 mRNA Translation: AAB18639.1
D85759 mRNA Translation: BAA12866.1
D86550 mRNA Translation: BAA13110.1
AF108830 mRNA Translation: AAD31169.1
AJ001870 mRNA Translation: CAA05059.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13653.1 [Q13627-2]
CCDS13654.1 [Q13627-3]
CCDS42925.1 [Q13627-1]
CCDS42926.1 [Q13627-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4898

NCBI Reference Sequences

More...
RefSeqi
NP_001334650.1, NM_001347721.1 [Q13627-2]
NP_001334651.1, NM_001347722.1 [Q13627-2]
NP_001387.2, NM_001396.4 [Q13627-1]
NP_567824.1, NM_101395.2 [Q13627-5]
NP_569120.1, NM_130436.2 [Q13627-2]
NP_569122.1, NM_130438.2 [Q13627-3]
XP_006724039.1, XM_006723976.3 [Q13627-1]
XP_006724040.1, XM_006723977.3 [Q13627-1]
XP_006724041.1, XM_006723978.3 [Q13627-1]
XP_011527785.1, XM_011529483.2 [Q13627-1]
XP_016883773.1, XM_017028284.1 [Q13627-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338785; ENSP00000342690; ENSG00000157540 [Q13627-5]
ENST00000339659; ENSP00000340373; ENSG00000157540 [Q13627-1]
ENST00000398956; ENSP00000381929; ENSG00000157540 [Q13627-3]
ENST00000398960; ENSP00000381932; ENSG00000157540 [Q13627-1]
ENST00000643624; ENSP00000493627; ENSG00000157540 [Q13627-2]
ENST00000644942; ENSP00000494544; ENSG00000157540 [Q13627-1]
ENST00000645424; ENSP00000494897; ENSG00000157540 [Q13627-4]
ENST00000646548; ENSP00000495908; ENSG00000157540 [Q13627-2]
ENST00000647188; ENSP00000494572; ENSG00000157540 [Q13627-2]
ENST00000647425; ENSP00000496748; ENSG00000157540 [Q13627-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1859

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1859

UCSC genome browser

More...
UCSCi
uc002ywi.4 human [Q13627-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58496 mRNA Translation: AAC50939.1
U52373 mRNA Translation: AAB18639.1
D85759 mRNA Translation: BAA12866.1
D86550 mRNA Translation: BAA13110.1
AF108830 mRNA Translation: AAD31169.1
AJ001870 mRNA Translation: CAA05059.1
CCDSiCCDS13653.1 [Q13627-2]
CCDS13654.1 [Q13627-3]
CCDS42925.1 [Q13627-1]
CCDS42926.1 [Q13627-5]
PIRiJC4898
RefSeqiNP_001334650.1, NM_001347721.1 [Q13627-2]
NP_001334651.1, NM_001347722.1 [Q13627-2]
NP_001387.2, NM_001396.4 [Q13627-1]
NP_567824.1, NM_101395.2 [Q13627-5]
NP_569120.1, NM_130436.2 [Q13627-2]
NP_569122.1, NM_130438.2 [Q13627-3]
XP_006724039.1, XM_006723976.3 [Q13627-1]
XP_006724040.1, XM_006723977.3 [Q13627-1]
XP_006724041.1, XM_006723978.3 [Q13627-1]
XP_011527785.1, XM_011529483.2 [Q13627-1]
XP_016883773.1, XM_017028284.1 [Q13627-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VX3X-ray2.40A/B/C/D127-485[»]
2WO6X-ray2.50A/B127-485[»]
3ANQX-ray2.60A/B/C/D126-490[»]
3ANRX-ray2.60A/B/C/D126-490[»]
4AZEX-ray3.15A/B/C128-485[»]
4MQ1X-ray2.35A/B/C/D127-485[»]
4MQ2X-ray2.80A/B/C/D127-485[»]
4NCTX-ray2.60A/B/C/D126-490[»]
4YLJX-ray2.58A/B/C/D127-485[»]
4YLKX-ray1.40A127-485[»]
4YLLX-ray1.40A127-485[»]
4YU2X-ray2.90A/B/C/D127-485[»]
5A3XX-ray2.26A/B/C/D126-490[»]
5A4EX-ray2.68A/B/C/D126-490[»]
5A4LX-ray2.73A/B/C/D126-490[»]
5A4QX-ray2.37A/B/C/D126-490[»]
5A4TX-ray2.15A/B/C/D126-490[»]
5A54X-ray2.63A/B/C/D126-490[»]
5AIKX-ray2.70A/B/C/D128-485[»]
6A1FX-ray1.50A127-483[»]
6A1GX-ray2.15A/B127-483[»]
6EIFX-ray2.22A/B/C/D126-490[»]
6EIJX-ray2.42A/B/C/D126-490[»]
6EILX-ray2.46A/B/C/D126-490[»]
6EIPX-ray2.56A/B/C/D126-490[»]
6EIQX-ray2.30A/B/C/D126-490[»]
6EIRX-ray2.40A/B/C/D126-490[»]
6EISX-ray2.36A/B/C/D126-490[»]
6EIVX-ray2.68A/B/C/D126-490[»]
6EJ4X-ray2.88A/B/C/D126-490[»]
6S11X-ray2.44A/B127-485[»]
6S14X-ray1.05A127-485[»]
6S17X-ray1.10A127-485[»]
6S1BX-ray1.30A127-485[»]
6S1HX-ray1.05A127-485[»]
6S1IX-ray2.38A/B/C/D127-485[»]
6S1JX-ray1.41A127-485[»]
SMRiQ13627
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108192, 85 interactors
DIPiDIP-39750N
ELMiQ13627
IntActiQ13627, 44 interactors
MINTiQ13627
STRINGi9606.ENSP00000381932

Chemistry databases

BindingDBiQ13627
ChEMBLiCHEMBL2292
DrugBankiDB12010 Fostamatinib
DB07608 N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
DrugCentraliQ13627
GuidetoPHARMACOLOGYi2009

PTM databases

iPTMnetiQ13627
PhosphoSitePlusiQ13627

Polymorphism and mutation databases

BioMutaiDYRK1A
DMDMi3219996

Proteomic databases

EPDiQ13627
jPOSTiQ13627
MassIVEiQ13627
MaxQBiQ13627
PaxDbiQ13627
PeptideAtlasiQ13627
PRIDEiQ13627
ProteomicsDBi59619 [Q13627-1]
59620 [Q13627-2]
59621 [Q13627-3]
59622 [Q13627-4]
59623 [Q13627-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1859

Genome annotation databases

EnsembliENST00000338785; ENSP00000342690; ENSG00000157540 [Q13627-5]
ENST00000339659; ENSP00000340373; ENSG00000157540 [Q13627-1]
ENST00000398956; ENSP00000381929; ENSG00000157540 [Q13627-3]
ENST00000398960; ENSP00000381932; ENSG00000157540 [Q13627-1]
ENST00000643624; ENSP00000493627; ENSG00000157540 [Q13627-2]
ENST00000644942; ENSP00000494544; ENSG00000157540 [Q13627-1]
ENST00000645424; ENSP00000494897; ENSG00000157540 [Q13627-4]
ENST00000646548; ENSP00000495908; ENSG00000157540 [Q13627-2]
ENST00000647188; ENSP00000494572; ENSG00000157540 [Q13627-2]
ENST00000647425; ENSP00000496748; ENSG00000157540 [Q13627-2]
GeneIDi1859
KEGGihsa:1859
UCSCiuc002ywi.4 human [Q13627-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1859
DisGeNETi1859

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DYRK1A
GeneReviewsiDYRK1A
HGNCiHGNC:3091 DYRK1A
HPAiHPA015323
HPA015810
MalaCardsiDYRK1A
MIMi600855 gene
614104 phenotype
neXtProtiNX_Q13627
OpenTargetsiENSG00000157540
Orphaneti268261 DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion
464311 Intellectual disability syndrome due to a DYRK1A point mutation
PharmGKBiPA27545

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
GeneTreeiENSGT00940000157408
HOGENOMiHOG000220863
InParanoidiQ13627
KOiK08825
OMAiPAYQFSA
OrthoDBi271572at2759
PhylomeDBiQ13627
TreeFamiTF314624

Enzyme and pathway databases

BRENDAi2.7.12.1 2681
ReactomeiR-HSA-1538133 G0 and Early G1
SignaLinkiQ13627
SIGNORiQ13627

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DYRK1A human
EvolutionaryTraceiQ13627

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DYRK1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1859
PharosiQ13627

Protein Ontology

More...
PROi
PR:Q13627

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157540 Expressed in 238 organ(s), highest expression level in forebrain
ExpressionAtlasiQ13627 baseline and differential
GenevisibleiQ13627 HS

Family and domain databases

InterProiView protein in InterPro
IPR028318 DYRK1A/B_MNB
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24058:SF12 PTHR24058:SF12, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYR1A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13627
Secondary accession number(s): O60769
, Q92582, Q92810, Q9UNM5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: October 16, 2019
This is version 205 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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