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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Gene

DYRK1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).By similarity4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.4 Publications

Activity regulationi

Inhibited by RANBP9 (PubMed:14500717). Inhibited by harmine, leucettamine B and leucettine L41 (PubMed:22998443).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei188ATPCurated1
Active sitei287Proton acceptor1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi165 – 173ATPCurated9
Nucleotide bindingi238 – 241ATPCurated4

GO - Molecular functioni

  • actin binding Source: ARUK-UCL
  • ATP binding Source: UniProtKB-KW
  • cytoskeletal protein binding Source: ARUK-UCL
  • identical protein binding Source: IntAct
  • non-membrane spanning protein tyrosine kinase activity Source: MGI
  • protein kinase activity Source: Reactome
  • protein self-association Source: UniProtKB
  • protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
  • protein serine/threonine kinase activity Source: ARUK-UCL
  • protein tyrosine kinase activity Source: UniProtKB
  • tau protein binding Source: ARUK-UCL
  • tubulin binding Source: ARUK-UCL

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.1 2681
ReactomeiR-HSA-1538133 G0 and Early G1
SignaLinkiQ13627
SIGNORiQ13627

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC:2.7.12.14 Publications)
Alternative name(s):
Dual specificity YAK1-related kinase
HP86
Protein kinase minibrain homolog
Short name:
MNBH
Short name:
hMNB
Gene namesi
Name:DYRK1A
Synonyms:DYRK, MNB, MNBH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000157540.19
HGNCiHGNC:3091 DYRK1A
MIMi600855 gene
neXtProtiNX_Q13627

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal dominant 7 (MRD7)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
See also OMIM:614104

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi188K → R: Abolishes kinase activity. 1 Publication1
Mutagenesisi321Y → F: Mildly reduces kinase activity. Does not abolish autophosphorylation on tyrosine residues. 1 Publication1

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNETi1859
MalaCardsiDYRK1A
MIMi614104 phenotype
OpenTargetsiENSG00000157540
Orphaneti268261 DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion
464311 Intellectual disability syndrome due to a DYRK1A point mutation
PharmGKBiPA27545

Chemistry databases

ChEMBLiCHEMBL2292
DrugBankiDB07608 N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
GuidetoPHARMACOLOGYi2009

Polymorphism and mutation databases

BioMutaiDYRK1A
DMDMi3219996

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859311 – 763Dual specificity tyrosine-phosphorylation-regulated kinase 1AAdd BLAST763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei111Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei140Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei145PhosphotyrosineCombined sources1
Modified residuei159Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei177Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei219Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei310Phosphoserine; by autocatalysis1 Publication1
Modified residuei319Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei321Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei402Phosphothreonine; by autocatalysis1 Publication1
Modified residuei449Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei529PhosphoserineCombined sources1
Modified residuei538PhosphoserineBy similarity1
Modified residuei748PhosphoserineCombined sources1
Modified residuei758PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13627
MaxQBiQ13627
PaxDbiQ13627
PeptideAtlasiQ13627
PRIDEiQ13627
ProteomicsDBi59619
59620 [Q13627-2]
59621 [Q13627-3]
59622 [Q13627-4]
59623 [Q13627-5]

PTM databases

iPTMnetiQ13627
PhosphoSitePlusiQ13627

Expressioni

Tissue specificityi

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.4 Publications

Developmental stagei

Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain.1 Publication

Gene expression databases

BgeeiENSG00000157540 Expressed in 238 organ(s), highest expression level in forebrain
CleanExiHS_DYRK1A
ExpressionAtlasiQ13627 baseline and differential
GenevisibleiQ13627 HS

Organism-specific databases

HPAiHPA015323
HPA015810

Interactioni

Subunit structurei

Interacts RAD54L2/ARIP4 (By similarity). Interacts with CRY2 (By similarity). Interacts with RANBP9 (PubMed:14500717). Interacts with WDR68 (PubMed:14593110). Interacts with SRSF6 (PubMed:22767602). Interacts with SIRT1 (By similarity).By similarity4 Publications
(Microbial infection) Interacts with human adenovirus 5 E1A protein (PubMed:23864635).1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108192, 80 interactors
DIPiDIP-39750N
ELMiQ13627
IntActiQ13627, 36 interactors
MINTiQ13627
STRINGi9606.ENSP00000381932

Chemistry databases

BindingDBiQ13627

Structurei

Secondary structure

1763
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13627
SMRiQ13627
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13627

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 479Protein kinasePROSITE-ProRule annotationAdd BLAST321

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi117 – 134Bipartite nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi509 – 515Poly-Ser7
Compositional biasi599 – 602Poly-His4
Compositional biasi607 – 619Poly-HisAdd BLAST13
Compositional biasi656 – 672Ser/Thr-richAdd BLAST17
Compositional biasi664 – 671Poly-Ser8

Domaini

The polyhistidine repeats act as targeting signals to nuclear speckles.1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
GeneTreeiENSGT00760000119032
HOGENOMiHOG000220863
HOVERGENiHBG051425
InParanoidiQ13627
KOiK08825
OMAiPTHYMTE
OrthoDBiEOG091G03J7
PhylomeDBiQ13627
TreeFamiTF314624

Family and domain databases

InterProiView protein in InterPro
IPR028318 DYRK1A/MNB
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24058:SF28 PTHR24058:SF28, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q13627-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD
60 70 80 90 100
QQVSALSYSD QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL
110 120 130 140 150
IKTYKHINEV YYAKKKRRHQ QGQGDDSSHK KERKVYNDGY DDDNYDYIVK
160 170 180 190 200
NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV EQEWVAIKII KNKKAFLNQA
210 220 230 240 250
QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM LSYNLYDLLR
260 270 280 290 300
NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR
310 320 330 340 350
SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI
360 370 380 390 400
LVEMHTGEPL FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD
410 420 430 440 450
GTWNLKKTKD GKREYKPPGT RKLHNILGVE TGGPGGRRAG ESGHTVADYL
460 470 480 490 500
KFKDLILRML DYDPKTRIQP YYALQHSFFK KTADEGTNTS NSVSTSPAME
510 520 530 540 550
QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG HFTAAVQAMD
560 570 580 590 600
CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH
610 620 630 640 650
HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH
660 670 680 690 700
SHHSMTSLSS STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV
710 720 730 740 750
NLTVYSNPRQ ETGIAGHPTY QFSANTGPAH YMTEGHLTMR QGADREESPM
760
TGVCVQQSPV ASS
Length:763
Mass (Da):85,584
Last modified:July 15, 1998 - v2
Checksum:i7C3A52A3CBB04FB5
GO
Isoform 1 (identifier: Q13627-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-78: Missing.

Show »
Length:754
Mass (Da):84,556
Checksum:i59518E25F1D4FF96
GO
Isoform 2 (identifier: Q13627-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-529: GGSSGTSNSGRARS → GASAISCSSWLVRH
     530-763: Missing.

Show »
Length:529
Mass (Da):60,330
Checksum:iF639B3152ACC7750
GO
Isoform 3 (identifier: Q13627-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: GGSSGTSNSG → GGAALDARCL
     526-763: Missing.

Show »
Length:525
Mass (Da):59,802
Checksum:i331976E38527AA3F
GO
Isoform 4 (identifier: Q13627-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     559-584: RQQFPAPLGWSGTEAPTQVTVETHPV → SSHVVHLLVSPAILRWSSTGCQVPLE
     585-763: Missing.

Show »
Length:584
Mass (Da):66,099
Checksum:iBA2480B34BAB2878
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y443A0A2R8Y443_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
400Annotation score:
A0A2R8Y6I6A0A2R8Y6I6_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
725Annotation score:
A0A2R8Y6L5A0A2R8Y6L5_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
605Annotation score:
A0A2R8YDF3A0A2R8YDF3_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
519Annotation score:
N0GVR9N0GVR9_HUMAN
Dual-specificity tyrosine-(Y)-phosp...
DYRK1A DYRK1A_var1, DYRK1A_var2
23Annotation score:
E7EMI5E7EMI5_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
181Annotation score:
A0A2R8YEY4A0A2R8YEY4_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK1A
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32G → A in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti47N → S in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti57S → P in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti123Q → R in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti266A → V in CAA05059 (PubMed:9503011).Curated1
Sequence conflicti357G → R in CAA05059 (PubMed:9503011).Curated1
Sequence conflicti397K → N in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti592A → G in AAC50939 (PubMed:8975710).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009395415Y → F1 Publication1
Natural variantiVAR_040453679A → P2 PublicationsCorresponds to variant dbSNP:rs55720916EnsemblClinVar.1
Natural variantiVAR_009396681Q → H1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00491770 – 78Missing in isoform 1. 2 Publications9
Alternative sequenceiVSP_004918516 – 529GGSSG…GRARS → GASAISCSSWLVRH in isoform 2. CuratedAdd BLAST14
Alternative sequenceiVSP_004920516 – 525GGSSGTSNSG → GGAALDARCL in isoform 3. Curated10
Alternative sequenceiVSP_004921526 – 763Missing in isoform 3. CuratedAdd BLAST238
Alternative sequenceiVSP_004919530 – 763Missing in isoform 2. CuratedAdd BLAST234
Alternative sequenceiVSP_004922559 – 584RQQFP…ETHPV → SSHVVHLLVSPAILRWSSTG CQVPLE in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_004923585 – 763Missing in isoform 4. 1 PublicationAdd BLAST179

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58496 mRNA Translation: AAC50939.1
U52373 mRNA Translation: AAB18639.1
D85759 mRNA Translation: BAA12866.1
D86550 mRNA Translation: BAA13110.1
AF108830 mRNA Translation: AAD31169.1
AJ001870 mRNA Translation: CAA05059.1
CCDSiCCDS13653.1 [Q13627-2]
CCDS13654.1 [Q13627-3]
CCDS42925.1 [Q13627-1]
CCDS42926.1 [Q13627-5]
PIRiJC4898
RefSeqiNP_001334650.1, NM_001347721.1 [Q13627-2]
NP_001334651.1, NM_001347722.1 [Q13627-2]
NP_001387.2, NM_001396.4 [Q13627-1]
NP_567824.1, NM_101395.2 [Q13627-5]
NP_569120.1, NM_130436.2 [Q13627-2]
NP_569122.1, NM_130438.2 [Q13627-3]
XP_006724039.1, XM_006723976.3 [Q13627-1]
XP_006724040.1, XM_006723977.3 [Q13627-1]
XP_006724041.1, XM_006723978.3 [Q13627-1]
XP_011527785.1, XM_011529483.2 [Q13627-1]
XP_016883773.1, XM_017028284.1 [Q13627-2]
UniGeneiHs.368240

Genome annotation databases

EnsembliENST00000338785; ENSP00000342690; ENSG00000157540 [Q13627-5]
ENST00000339659; ENSP00000340373; ENSG00000157540 [Q13627-1]
ENST00000398956; ENSP00000381929; ENSG00000157540 [Q13627-3]
ENST00000398960; ENSP00000381932; ENSG00000157540 [Q13627-1]
ENST00000643624; ENSP00000493627; ENSG00000157540 [Q13627-2]
ENST00000644942; ENSP00000494544; ENSG00000157540 [Q13627-1]
ENST00000645424; ENSP00000494897; ENSG00000157540 [Q13627-4]
ENST00000646548; ENSP00000495908; ENSG00000157540 [Q13627-2]
ENST00000647188; ENSP00000494572; ENSG00000157540 [Q13627-2]
ENST00000647425; ENSP00000496748; ENSG00000157540 [Q13627-2]
GeneIDi1859
KEGGihsa:1859
UCSCiuc002ywi.4 human [Q13627-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58496 mRNA Translation: AAC50939.1
U52373 mRNA Translation: AAB18639.1
D85759 mRNA Translation: BAA12866.1
D86550 mRNA Translation: BAA13110.1
AF108830 mRNA Translation: AAD31169.1
AJ001870 mRNA Translation: CAA05059.1
CCDSiCCDS13653.1 [Q13627-2]
CCDS13654.1 [Q13627-3]
CCDS42925.1 [Q13627-1]
CCDS42926.1 [Q13627-5]
PIRiJC4898
RefSeqiNP_001334650.1, NM_001347721.1 [Q13627-2]
NP_001334651.1, NM_001347722.1 [Q13627-2]
NP_001387.2, NM_001396.4 [Q13627-1]
NP_567824.1, NM_101395.2 [Q13627-5]
NP_569120.1, NM_130436.2 [Q13627-2]
NP_569122.1, NM_130438.2 [Q13627-3]
XP_006724039.1, XM_006723976.3 [Q13627-1]
XP_006724040.1, XM_006723977.3 [Q13627-1]
XP_006724041.1, XM_006723978.3 [Q13627-1]
XP_011527785.1, XM_011529483.2 [Q13627-1]
XP_016883773.1, XM_017028284.1 [Q13627-2]
UniGeneiHs.368240

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VX3X-ray2.40A/B/C/D127-485[»]
2WO6X-ray2.50A/B127-485[»]
3ANQX-ray2.60A/B/C/D126-490[»]
3ANRX-ray2.60A/B/C/D126-490[»]
4AZEX-ray3.15A/B/C128-485[»]
4MQ1X-ray2.35A/B/C/D127-485[»]
4MQ2X-ray2.80A/B/C/D127-485[»]
4NCTX-ray2.60A/B/C/D126-490[»]
4YLJX-ray2.58A/B/C/D127-485[»]
4YLKX-ray1.40A127-485[»]
4YLLX-ray1.40A127-485[»]
4YU2X-ray2.90A/B/C/D127-485[»]
5A3XX-ray2.26A/B/C/D126-490[»]
5A4EX-ray2.68A/B/C/D126-490[»]
5A4LX-ray2.73A/B/C/D126-490[»]
5A4QX-ray2.37A/B/C/D126-490[»]
5A4TX-ray2.15A/B/C/D126-490[»]
5A54X-ray2.63A/B/C/D126-490[»]
5AIKX-ray2.70A/B/C/D128-485[»]
6EIFX-ray2.22A/B/C/D126-490[»]
6EIJX-ray2.42A/B/C/D126-490[»]
6EILX-ray2.46A/B/C/D126-490[»]
6EIPX-ray2.56A/B/C/D126-490[»]
6EIQX-ray2.30A/B/C/D126-490[»]
6EIRX-ray2.40A/B/C/D126-490[»]
6EISX-ray2.36A/B/C/D126-490[»]
6EIVX-ray2.68A/B/C/D126-490[»]
6EJ4X-ray2.88A/B/C/D126-490[»]
ProteinModelPortaliQ13627
SMRiQ13627
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108192, 80 interactors
DIPiDIP-39750N
ELMiQ13627
IntActiQ13627, 36 interactors
MINTiQ13627
STRINGi9606.ENSP00000381932

Chemistry databases

BindingDBiQ13627
ChEMBLiCHEMBL2292
DrugBankiDB07608 N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
GuidetoPHARMACOLOGYi2009

PTM databases

iPTMnetiQ13627
PhosphoSitePlusiQ13627

Polymorphism and mutation databases

BioMutaiDYRK1A
DMDMi3219996

Proteomic databases

EPDiQ13627
MaxQBiQ13627
PaxDbiQ13627
PeptideAtlasiQ13627
PRIDEiQ13627
ProteomicsDBi59619
59620 [Q13627-2]
59621 [Q13627-3]
59622 [Q13627-4]
59623 [Q13627-5]

Protocols and materials databases

DNASUi1859
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338785; ENSP00000342690; ENSG00000157540 [Q13627-5]
ENST00000339659; ENSP00000340373; ENSG00000157540 [Q13627-1]
ENST00000398956; ENSP00000381929; ENSG00000157540 [Q13627-3]
ENST00000398960; ENSP00000381932; ENSG00000157540 [Q13627-1]
ENST00000643624; ENSP00000493627; ENSG00000157540 [Q13627-2]
ENST00000644942; ENSP00000494544; ENSG00000157540 [Q13627-1]
ENST00000645424; ENSP00000494897; ENSG00000157540 [Q13627-4]
ENST00000646548; ENSP00000495908; ENSG00000157540 [Q13627-2]
ENST00000647188; ENSP00000494572; ENSG00000157540 [Q13627-2]
ENST00000647425; ENSP00000496748; ENSG00000157540 [Q13627-2]
GeneIDi1859
KEGGihsa:1859
UCSCiuc002ywi.4 human [Q13627-1]

Organism-specific databases

CTDi1859
DisGeNETi1859
EuPathDBiHostDB:ENSG00000157540.19
GeneCardsiDYRK1A
HGNCiHGNC:3091 DYRK1A
HPAiHPA015323
HPA015810
MalaCardsiDYRK1A
MIMi600855 gene
614104 phenotype
neXtProtiNX_Q13627
OpenTargetsiENSG00000157540
Orphaneti268261 DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion
464311 Intellectual disability syndrome due to a DYRK1A point mutation
PharmGKBiPA27545
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
GeneTreeiENSGT00760000119032
HOGENOMiHOG000220863
HOVERGENiHBG051425
InParanoidiQ13627
KOiK08825
OMAiPTHYMTE
OrthoDBiEOG091G03J7
PhylomeDBiQ13627
TreeFamiTF314624

Enzyme and pathway databases

BRENDAi2.7.12.1 2681
ReactomeiR-HSA-1538133 G0 and Early G1
SignaLinkiQ13627
SIGNORiQ13627

Miscellaneous databases

ChiTaRSiDYRK1A human
EvolutionaryTraceiQ13627
GeneWikiiDYRK1A
GenomeRNAii1859
PROiPR:Q13627
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157540 Expressed in 238 organ(s), highest expression level in forebrain
CleanExiHS_DYRK1A
ExpressionAtlasiQ13627 baseline and differential
GenevisibleiQ13627 HS

Family and domain databases

InterProiView protein in InterPro
IPR028318 DYRK1A/MNB
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24058:SF28 PTHR24058:SF28, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDYR1A_HUMAN
AccessioniPrimary (citable) accession number: Q13627
Secondary accession number(s): O60769
, Q92582, Q92810, Q9UNM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 198 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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