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Entry version 208 (12 Aug 2020)
Sequence version 2 (15 Aug 2003)
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Protein

Apoptosis-stimulating of p53 protein 2

Gene

TP53BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Cell cycle

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q13625

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-139915, Activation of PUMA and translocation to mitochondria
R-HSA-6803204, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors

SIGNOR Signaling Network Open Resource

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SIGNORi
Q13625

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apoptosis-stimulating of p53 protein 2
Alternative name(s):
Bcl2-binding protein
Short name:
Bbp
Renal carcinoma antigen NY-REN-51
Tumor suppressor p53-binding protein 2
Short name:
53BP2
Short name:
p53-binding protein 2
Short name:
p53BP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TP53BP2
Synonyms:ASPP2, BBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000143514.16

Human Gene Nomenclature Database

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HGNCi
HGNC:12000, TP53BP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602143, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13625

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1098W → K: Loss of interaction with APC2. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7159

Open Targets

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OpenTargetsi
ENSG00000143514

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36681

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q13625, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TP53BP2

Domain mapping of disease mutations (DMDM)

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DMDMi
33860140

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669641 – 1128Apoptosis-stimulating of p53 protein 2Add BLAST1128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei480PhosphoserineCombined sources1
Modified residuei556PhosphoserineCombined sources1
Modified residuei569PhosphoserineCombined sources1
Modified residuei572PhosphoserineCombined sources1
Modified residuei576PhosphoserineCombined sources1
Modified residuei698PhosphoserineBy similarity1
Modified residuei714PhosphoserineCombined sources1
Modified residuei737PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13625

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13625

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13625

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13625

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13625

PeptideAtlas

More...
PeptideAtlasi
Q13625

PRoteomics IDEntifications database

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PRIDEi
Q13625

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
59616 [Q13625-1]
59617 [Q13625-2]
59618 [Q13625-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13625

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q13625

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13625

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Following DNA damage induced by UV irradiation. Down-regulated by wild-type, but not mutant, p53/TP53.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000143514, Expressed in substantia nigra and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13625, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13625, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000143514, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with P53/TP53; the interaction promotes pro-apoptotic activity (PubMed:11684014, PubMed:8016121, PubMed:12524540).

Interacts with BCL2 (PubMed:8668206).

Interacts with protein phosphatase 1.

Interacts with RELA NF-kappa-B subunit. This interaction probably prevents the activation of apoptosis, possibly by preventing its interaction with TP53.

Interacts with APC2 and APPBP1.

Interacts with DDX42 (via the C-terminus); the interaction is not inhibited by TP53BP2 ubiquitination and is independent of p53/TP53.

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q13625
With#Exp.IntAct
APC2 [O95996]4EBI-77642,EBI-1053045
APP [P05067]3EBI-77642,EBI-77613
BCL2 [P10415]10EBI-77642,EBI-77694
BCL2L1 - isoform Bcl-X(L) [Q07817-1]3EBI-77642,EBI-287195
BCL2L2 [Q92843]4EBI-77642,EBI-707714
CTNNB1 [P35222]5EBI-77642,EBI-491549
EP300 [Q09472]2EBI-77642,EBI-447295
ITCH [Q96J02]2EBI-77642,EBI-1564678
PPP1CA [P62136]9EBI-77642,EBI-357253
PPP1CC [P36873]8EBI-77642,EBI-356283
RAN [P62826]5EBI-77642,EBI-286642
RELA [Q04206]4EBI-77642,EBI-73886
TP53 [P04637]9EBI-77642,EBI-366083
itself7EBI-77642,EBI-77642
TP63 [Q9H3D4]2EBI-77642,EBI-2337775
TP73 [O15350]2EBI-77642,EBI-389606
YWHAZ [P63104]3EBI-77642,EBI-347088
Core protein p21 (PRO_0000037566) from Hepatitis C virus genotype 1a (isolate H).5EBI-77642,EBI-6377335
Isoform 2 [Q13625-2]
With#Exp.IntAct
RELA [Q04206]6EBI-287091,EBI-73886
YAP1 [P46937]9EBI-287091,EBI-1044059
Irs1 [P35569] from Mus musculus.2EBI-287091,EBI-400825
Irs1 [P35570] from Rattus norvegicus.4EBI-287091,EBI-520230
YAP1 [P46936] from Gallus gallus.6EBI-287091,EBI-7804091
Isoform 3 [Q13625-3]
With#Exp.IntAct
ATPAF2 [Q8N5M1]3EBI-10175039,EBI-1166928
BAIAP2 [Q9UQB8]3EBI-10175039,EBI-525456
CCDC92 [Q53HC0]3EBI-10175039,EBI-719994
CWF19L2 [Q2TBE0]3EBI-10175039,EBI-5453285
DCUN1D1 [Q96GG9]3EBI-10175039,EBI-740086
GRB2 [P62993]3EBI-10175039,EBI-401755
H2BC8 [P62807]3EBI-10175039,EBI-354552
HNRNPUL1 [Q9BUJ2]3EBI-10175039,EBI-1018153
LMO4 [P61968]3EBI-10175039,EBI-2798728
MTMR14 [Q8NCE2]3EBI-10175039,EBI-5658424
NDC80 [O14777]3EBI-10175039,EBI-715849
NUTM1 [Q86Y26]3EBI-10175039,EBI-10178410
NXF1 [Q9UBU9]3EBI-10175039,EBI-398874
OTUB2 [Q96DC9]3EBI-10175039,EBI-746259
PLEKHN1 [Q494U1]3EBI-10175039,EBI-10241513
POLR2L [P62875]3EBI-10175039,EBI-359527
PPP1CB [P62140]3EBI-10175039,EBI-352350
PPP1CC [P36873]3EBI-10175039,EBI-356283
PRPF31 [Q8WWY3]3EBI-10175039,EBI-1567797
SIAH1 [Q8IUQ4]3EBI-10175039,EBI-747107
SSX2IP [Q9Y2D8]3EBI-10175039,EBI-2212028
TANK [Q92844]3EBI-10175039,EBI-356349
TBC1D22B [Q9NU19]3EBI-10175039,EBI-8787464
TCL1A [P56279]3EBI-10175039,EBI-749995
TRAF4 [Q9BUZ4]3EBI-10175039,EBI-3650647
TXLNA [P40222]3EBI-10175039,EBI-359793
UBASH3A [P57075]3EBI-10175039,EBI-2105393
ZGPAT [Q8N5A5]3EBI-10175039,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-10175039,EBI-10183064
ZNF26 [P17031]5EBI-10175039,EBI-2841331

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
113012, 129 interactors

Database of interacting proteins

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DIPi
DIP-426N

Protein interaction database and analysis system

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IntActi
Q13625, 129 interactors

Molecular INTeraction database

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MINTi
Q13625

STRING: functional protein association networks

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STRINGi
9606.ENSP00000341957

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q13625, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13625

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13625

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati926 – 957ANK 1Add BLAST32
Repeati958 – 990ANK 2Add BLAST33
Repeati991 – 1024ANK 3Add BLAST34
Repeati1025 – 1067ANK 4Add BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1057 – 1119SH3PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni332 – 348Interaction with APPBP11 PublicationAdd BLAST17
Regioni876 – 1128Mediates interaction with APC21 PublicationAdd BLAST253

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi866 – 875SH3-bindingSequence analysis10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi132 – 173Gln-richAdd BLAST42
Compositional biasi824 – 902Pro-richAdd BLAST79

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ASPP family.Curated

Keywords - Domaini

ANK repeat, Repeat, SH3 domain, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0515, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153463

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_008234_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13625

KEGG Orthology (KO)

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KOi
K16823

Identification of Orthologs from Complete Genome Data

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OMAi
MREGDCM

Database of Orthologous Groups

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OrthoDBi
1041229at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13625

TreeFam database of animal gene trees

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TreeFami
TF105545

Family and domain databases

Database of protein disorder

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DisProti
DP01164

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00124

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248, ANK, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13625-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MMPMFLTVYL SNNEQHFTEV PVTPETICRD VVDLCKEPGE SDCHLAEVWC
60 70 80 90 100
GSERPVADNE RMFDVLQRFG SQRNEVRFFL RHERPPGRDI VSGPRSQDPS
110 120 130 140 150
LKRNGVKVPG EYRRKENGVN SPRMDLTLAE LQEMASRQQQ QIEAQQQLLA
160 170 180 190 200
TKEQRLKFLK QQDQRQQQQV AEQEKLKRLK EIAENQEAKL KKVRALKGHV
210 220 230 240 250
EQKRLSNGKL VEEIEQMNNL FQQKQRELVL AVSKVEELTR QLEMLKNGRI
260 270 280 290 300
DSHHDNQSAV AELDRLYKEL QLRNKLNQEQ NAKLQQQREC LNKRNSEVAV
310 320 330 340 350
MDKRVNELRD RLWKKKAALQ QKENLPVSSD GNLPQQAASA PSRVAAVGPY
360 370 380 390 400
IQSSTMPRMP SRPELLVKPA LPDGSLVIQA SEGPMKIQTL PNMRSGAASQ
410 420 430 440 450
TKGSKIHPVG PDWSPSNADL FPSQGSASVP QSTGNALDQV DDGEVPLREK
460 470 480 490 500
EKKVRPFSMF DAVDQSNAPP SFGTLRKNQS SEDILRDAQV ANKNVAKVPP
510 520 530 540 550
PVPTKPKQIN LPYFGQTNQP PSDIKPDGSS QQLSTVVPSM GTKPKPAGQQ
560 570 580 590 600
PRVLLSPSIP SVGQDQTLSP GSKQESPPAA AVRPFTPQPS KDTLLPPFRK
610 620 630 640 650
PQTVAASSIY SMYTQQQAPG KNFQQAVQSA LTKTHTRGPH FSSVYGKPVI
660 670 680 690 700
AAAQNQQQHP ENIYSNSQGK PGSPEPETEP VSSVQENHEN ERIPRPLSPT
710 720 730 740 750
KLLPFLSNPY RNQSDADLEA LRKKLSNAPR PLKKRSSITE PEGPNGPNIQ
760 770 780 790 800
KLLYQRTTIA AMETISVPSY PSKSASVTAS SESPVEIQNP YLHVEPEKEV
810 820 830 840 850
VSLVPESLSP EDVGNASTEN SDMPAPSPGL DYEPEGVPDN SPNLQNNPEE
860 870 880 890 900
PNPEAPHVLD VYLEEYPPYP PPPYPSGEPE GPGEDSVSMR PPEITGQVSL
910 920 930 940 950
PPGKRTNLRK TGSERIAHGM RVKFNPLALL LDSSLEGEFD LVQRIIYEVD
960 970 980 990 1000
DPSLPNDEGI TALHNAVCAG HTEIVKFLVQ FGVNVNAADS DGWTPLHCAA
1010 1020 1030 1040 1050
SCNNVQVCKF LVESGAAVFA MTYSDMQTAA DKCEEMEEGY TQCSQFLYGV
1060 1070 1080 1090 1100
QEKMGIMNKG VIYALWDYEP QNDDELPMKE GDCMTIIHRE DEDEIEWWWA
1110 1120
RLNDKEGYVP RNLLGLYPRI KPRQRSLA
Length:1,128
Mass (Da):125,616
Last modified:August 15, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC75D056FBC1DAD75
GO
Isoform 2 (identifier: Q13625-2) [UniParc]FASTAAdd to basket
Also known as: Bbp

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: Due to Alu sequence insertion that creates a shorter but existing form that may have an alternative function.Curated
Show »
Length:1,005
Mass (Da):111,431
Checksum:i3DF4FF49EB589F20
GO
Isoform 3 (identifier: Q13625-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRFGSKM

Show »
Length:1,134
Mass (Da):126,323
Checksum:i2C7683F88B171926
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5L8H7C5L8_HUMAN
Apoptosis-stimulating of p53 protei...
TP53BP2
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBY9F8WBY9_HUMAN
Apoptosis-stimulating of p53 protei...
TP53BP2
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y847H0Y847_HUMAN
Apoptosis-stimulating of p53 protei...
TP53BP2
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH46150 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH46150 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH58918 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0080101 – 123Missing in isoform 2. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_0435091M → MRFGSKM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U58334 mRNA Translation: AAC50557.1
AJ318888 mRNA Translation: CAC83012.1
AK294432 mRNA Translation: BAG57677.1
AC096542 Genomic DNA No translation available.
BC046150 mRNA Translation: AAH46150.2 Sequence problems.
BC058918 mRNA Translation: AAH58918.2 Different initiation.
U09582 mRNA Translation: AAA21597.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1538.1 [Q13625-2]
CCDS44319.1 [Q13625-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
I38607

NCBI Reference Sequences

More...
RefSeqi
NP_001026855.2, NM_001031685.2 [Q13625-3]
NP_005417.1, NM_005426.2 [Q13625-2]
XP_011542571.1, XM_011544269.2 [Q13625-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343537; ENSP00000341957; ENSG00000143514 [Q13625-3]
ENST00000391878; ENSP00000375750; ENSG00000143514 [Q13625-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7159

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7159

UCSC genome browser

More...
UCSCi
uc001hod.4, human [Q13625-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58334 mRNA Translation: AAC50557.1
AJ318888 mRNA Translation: CAC83012.1
AK294432 mRNA Translation: BAG57677.1
AC096542 Genomic DNA No translation available.
BC046150 mRNA Translation: AAH46150.2 Sequence problems.
BC058918 mRNA Translation: AAH58918.2 Different initiation.
U09582 mRNA Translation: AAA21597.1
CCDSiCCDS1538.1 [Q13625-2]
CCDS44319.1 [Q13625-3]
PIRiI38607
RefSeqiNP_001026855.2, NM_001031685.2 [Q13625-3]
NP_005417.1, NM_005426.2 [Q13625-2]
XP_011542571.1, XM_011544269.2 [Q13625-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YCSX-ray2.20B892-1126[»]
2UWQNMR-A1-83[»]
4A63X-ray2.27B/D/F/H/J/L892-1128[»]
4IRVX-ray2.04E/F/G/H726-782[»]
6GHMX-ray2.15C/D920-1128[»]
6HKPX-ray1.90S970-992[»]
SMRiQ13625
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113012, 129 interactors
DIPiDIP-426N
IntActiQ13625, 129 interactors
MINTiQ13625
STRINGi9606.ENSP00000341957

PTM databases

iPTMnetiQ13625
MetOSiteiQ13625
PhosphoSitePlusiQ13625

Polymorphism and mutation databases

BioMutaiTP53BP2
DMDMi33860140

Proteomic databases

EPDiQ13625
jPOSTiQ13625
MassIVEiQ13625
MaxQBiQ13625
PaxDbiQ13625
PeptideAtlasiQ13625
PRIDEiQ13625
ProteomicsDBi59616 [Q13625-1]
59617 [Q13625-2]
59618 [Q13625-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
20749, 262 antibodies

Genome annotation databases

EnsembliENST00000343537; ENSP00000341957; ENSG00000143514 [Q13625-3]
ENST00000391878; ENSP00000375750; ENSG00000143514 [Q13625-2]
GeneIDi7159
KEGGihsa:7159
UCSCiuc001hod.4, human [Q13625-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7159
DisGeNETi7159
EuPathDBiHostDB:ENSG00000143514.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TP53BP2
HGNCiHGNC:12000, TP53BP2
HPAiENSG00000143514, Low tissue specificity
MIMi602143, gene
neXtProtiNX_Q13625
OpenTargetsiENSG00000143514
PharmGKBiPA36681

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0515, Eukaryota
GeneTreeiENSGT00940000153463
HOGENOMiCLU_008234_0_0_1
InParanoidiQ13625
KOiK16823
OMAiMREGDCM
OrthoDBi1041229at2759
PhylomeDBiQ13625
TreeFamiTF105545

Enzyme and pathway databases

PathwayCommonsiQ13625
ReactomeiR-HSA-139915, Activation of PUMA and translocation to mitochondria
R-HSA-6803204, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors
SIGNORiQ13625

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7159, 12 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TP53BP2, human
EvolutionaryTraceiQ13625

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TP53BP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7159
PharosiQ13625, Tbio

Protein Ontology

More...
PROi
PR:Q13625
RNActiQ13625, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143514, Expressed in substantia nigra and 234 other tissues
ExpressionAtlasiQ13625, baseline and differential
GenevisibleiQ13625, HS

Family and domain databases

DisProtiDP01164
Gene3Di1.25.40.20, 1 hit
IDEALiIID00124
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASPP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13625
Secondary accession number(s): B4DG66
, Q12892, Q86X75, Q96KQ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 15, 2003
Last modified: August 12, 2020
This is version 208 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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