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Protein

Cullin-4B

Gene

CUL4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.7 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, DNA damage, DNA repair, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-8951664 Neddylation
SIGNORiQ13620
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Cullin-4B
Short name:
CUL-4B
Gene namesi
Name:CUL4B
Synonyms:KIAA0695
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000158290.16
HGNCiHGNC:2555 CUL4B
MIMi300304 gene
neXtProtiNX_Q13620

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked, syndromic, 15 (MRXS15)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndromic form of X-linked mental retardation characterized by severe intellectual deficit associated with short stature, craniofacial dysmorphism, small testes, muscle wasting in lower legs, kyphosis, joint hyperextensibility, pes cavus, small feet, and abnormalities of the toes. Additional neurologic manifestations include speech delay and impairment, tremor, seizures, gait ataxia, hyperactivity and decreased attention span.
See also OMIM:300354
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032273213T → I in MRXS15; uncertain pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs763692058Ensembl.1
Natural variantiVAR_032274572R → C in MRXS15. 2 PublicationsCorresponds to variant dbSNP:rs121434615EnsemblClinVar.1
Natural variantiVAR_032275745V → A in MRXS15. 2 Publications1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi55 – 58Missing : Distributed in cytoplasm. Fails to promote cell proliferation. No binding to KPNA2, KPNA4 and KPNA1. 1 Publication4
Mutagenesisi55K → A: No impairment in nuclear localization. 1 Publication1
Mutagenesisi56K → A: Disrupts nuclear localization and does not bind KPNA2, KPNA4, KPNA1; when associated with A-57. Disrupts nuclear localization. 1 Publication1
Mutagenesisi57R → A: Disrupts nuclear localization and does not bind KPNA2, KPNA4, KPNA1; when associated with A-56. Disrupts nuclear localization. 1 Publication1
Mutagenesisi58K → A: No impairment in nuclear localization. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism, Mental retardation

Organism-specific databases

DisGeNETi8450
MalaCardsiCUL4B
MIMi300354 phenotype
OpenTargetsiENSG00000158290
Orphaneti85293 X-linked intellectual disability, Cabezas type
PharmGKBiPA27051

Polymorphism and mutation databases

BioMutaiCUL4B
DMDMi296439468

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003939461 – 913Cullin-4BAdd BLAST913

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphothreonineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei100PhosphoserineBy similarity1
Modified residuei146PhosphoserineCombined sources1
Modified residuei148PhosphothreonineBy similarity1
Cross-linki190Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei193PhosphoserineCombined sources1
Cross-linki859Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)By similarity
Isoform 2 (identifier: Q13620-1)
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei10PhosphoserineCombined sources1

Post-translational modificationi

Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13620
PaxDbiQ13620
PeptideAtlasiQ13620
PRIDEiQ13620
ProteomicsDBi59611
59612 [Q13620-1]
59613 [Q13620-3]

PTM databases

iPTMnetiQ13620
PhosphoSitePlusiQ13620
SwissPalmiQ13620

Miscellaneous databases

PMAP-CutDBiQ13620

Expressioni

Gene expression databases

BgeeiENSG00000158290 Expressed in 232 organ(s), highest expression level in testis
CleanExiHS_CUL4B
ExpressionAtlasiQ13620 baseline and differential
GenevisibleiQ13620 HS

Organism-specific databases

HPAiCAB017786
HPA003046
HPA011880
HPA058979

Interactioni

Subunit structurei

Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to be formed of DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Component of the DCX(DTL) complex with the putative substrate recognition component DTL. Component of the DCX(DDB2) complex with the putative substrate recognition component DDB2. Part of a complex with RBX1 and TIP120A/CAND1. Interacts with RBX1 GRWD1, MLST8, SMU1, TLE2, TLE3, DCAF1, DDA1, DCAF6, DCAF17, DDB2, DCAF8, TIP120A/CAND1 and TMEM113. Interacts with cyclin E and with importins alpha-1 (KPNA2), alpha-3 (KPNA4), alpha-5 (KPNA1) and beta-1 (KPNB1). May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76 and WDR5.11 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114028, 377 interactors
ComplexPortaliCPX-648 CRL4-DDB2 E3 ubiquitin ligase complex, CUL4B variant
CORUMiQ13620
DIPiDIP-31609N
IntActiQ13620, 59 interactors
MINTiQ13620
STRINGi9606.ENSP00000384109

Structurei

Secondary structure

1913
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13620
SMRiQ13620
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13620

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 58Nuclear localization signal1 Publication4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 193Ser-richAdd BLAST191

Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2167 Eukaryota
COG5647 LUCA
GeneTreeiENSGT00760000119212
HOVERGENiHBG003619
InParanoidiQ13620
KOiK10609
OMAiDFRHKLF
OrthoDBiEOG091G02DP
PhylomeDBiQ13620
TreeFamiTF101153

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR033044 CUL4B
IPR016157 Cullin_CS
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR019559 Cullin_neddylation_domain
IPR016159 Cullin_repeat-like_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11932:SF66 PTHR11932:SF66, 1 hit
PfamiView protein in Pfam
PF00888 Cullin, 1 hit
PF10557 Cullin_Nedd8, 1 hit
SMARTiView protein in SMART
SM00182 CULLIN, 1 hit
SM00884 Cullin_Nedd8, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF74788 SSF74788, 1 hit
SSF75632 SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS01256 CULLIN_1, 1 hit
PS50069 CULLIN_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13620-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSQSSGSGD GNDDEATTSK DGGFSSPSPS AAAAAQEVRS ATDGNTSTTP
60 70 80 90 100
PTSAKKRKLN SSSSSSSNSS NEREDFDSTS SSSSTPPLQP RDSASPSTSS
110 120 130 140 150
FCLGVSVAAS SHVPIQKKLR FEDTLEFVGF DAKMAEESSS SSSSSSPTAA
160 170 180 190 200
TSQQQQLKNK SILISSVASV HHANGLAKSS TTVSSFANSK PGSAKKLVIK
210 220 230 240 250
NFKDKPKLPE NYTDETWQKL KEAVEAIQNS TSIKYNLEEL YQAVENLCSY
260 270 280 290 300
KISANLYKQL RQICEDHIKA QIHQFREDSL DSVLFLKKID RCWQNHCRQM
310 320 330 340 350
IMIRSIFLFL DRTYVLQNSM LPSIWDMGLE LFRAHIISDQ KVQNKTIDGI
360 370 380 390 400
LLLIERERNG EAIDRSLLRS LLSMLSDLQI YQDSFEQRFL EETNRLYAAE
410 420 430 440 450
GQKLMQEREV PEYLHHVNKR LEEEADRLIT YLDQTTQKSL IATVEKQLLG
460 470 480 490 500
EHLTAILQKG LNNLLDENRI QDLSLLYQLF SRVRGGVQVL LQQWIEYIKA
510 520 530 540 550
FGSTIVINPE KDKTMVQELL DFKDKVDHII DICFLKNEKF INAMKEAFET
560 570 580 590 600
FINKRPNKPA ELIAKYVDSK LRAGNKEATD EELEKMLDKI MIIFRFIYGK
610 620 630 640 650
DVFEAFYKKD LAKRLLVGKS ASVDAEKSML SKLKHECGAA FTSKLEGMFK
660 670 680 690 700
DMELSKDIMI QFKQYMQNQN VPGNIELTVN ILTMGYWPTY VPMEVHLPPE
710 720 730 740 750
MVKLQEIFKT FYLGKHSGRK LQWQSTLGHC VLKAEFKEGK KELQVSLFQT
760 770 780 790 800
LVLLMFNEGE EFSLEEIKQA TGIEDGELRR TLQSLACGKA RVLAKNPKGK
810 820 830 840 850
DIEDGDKFIC NDDFKHKLFR IKINQIQMKE TVEEQASTTE RVFQDRQYQI
860 870 880 890 900
DAAIVRIMKM RKTLSHNLLV SEVYNQLKFP VKPADLKKRI ESLIDRDYME
910
RDKENPNQYN YIA
Length:913
Mass (Da):103,982
Last modified:May 18, 2010 - v4
Checksum:i3E58C5868FDF0700
GO
Isoform 2 (identifier: Q13620-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MMSQSSGSGDGNDDEATTSKDG → MFPT

Show »
Length:895
Mass (Da):102,299
Checksum:i25B25D253C1C2B71
GO
Isoform 3 (identifier: Q13620-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.
     197-203: LVIKNFK → MIDPDFA

Show »
Length:717
Mass (Da):84,017
Checksum:iD50E2D33B73E6CB9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K4DI93K4DI93_HUMAN
Cullin 4B, isoform CRA_e
CUL4B hCG_40765
900Annotation score:
A6NE76A6NE76_HUMAN
Cullin-4B
CUL4B
234Annotation score:

Sequence cautioni

The sequence AAB67315 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAK16812 differs from that shown. Reason: Frameshift at position 115.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69S → R in BAG53936 (PubMed:14702039).Curated1
Sequence conflicti126E → G in CAD97843 (PubMed:17974005).Curated1
Sequence conflicti142S → P in BAG53936 (PubMed:14702039).Curated1
Sequence conflicti196K → N in AAK16812 (Ref. 2) Curated1
Sequence conflicti265E → G in BAG53936 (PubMed:14702039).Curated1
Sequence conflicti268I → M in AAK16812 (Ref. 2) Curated1
Sequence conflicti485G → D in CAD97843 (PubMed:17974005).Curated1
Sequence conflicti664Q → QVK in AAK16812 (Ref. 2) Curated1
Sequence conflicti727L → I in AAR13073 (PubMed:14578910).Curated1
Sequence conflicti727L → I in AAH36216 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032272103L → P1 PublicationCorresponds to variant dbSNP:rs61759504Ensembl.1
Natural variantiVAR_032273213T → I in MRXS15; uncertain pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs763692058Ensembl.1
Natural variantiVAR_032274572R → C in MRXS15. 2 PublicationsCorresponds to variant dbSNP:rs121434615EnsemblClinVar.1
Natural variantiVAR_032275745V → A in MRXS15. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0390841 – 196Missing in isoform 3. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_0390851 – 22MMSQS…TSKDG → MFPT in isoform 2. 4 PublicationsAdd BLAST22
Alternative sequenceiVSP_039086197 – 203LVIKNFK → MIDPDFA in isoform 3. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY365125 mRNA Translation: AAR13073.1
AF212995 mRNA Translation: AAK16812.1 Frameshift.
AK123688 mRNA Translation: BAG53936.1
AK299081 mRNA Translation: BAH12944.1
AK315037 mRNA Translation: BAG37520.1
BX537787 mRNA Translation: CAD97843.1
AC002476 Genomic DNA Translation: AAB67315.1 Sequence problems.
AL451005 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11877.1
BC036216 mRNA Translation: AAH36216.1
AB014595 mRNA Translation: BAA31670.2
U58091 mRNA Translation: AAC50548.1
CCDSiCCDS35379.1 [Q13620-2]
CCDS43987.1 [Q13620-1]
RefSeqiNP_001073341.1, NM_001079872.1 [Q13620-1]
NP_003579.3, NM_003588.3 [Q13620-2]
XP_011529702.1, XM_011531400.2 [Q13620-3]
UniGeneiHs.102914

Genome annotation databases

EnsembliENST00000371322; ENSP00000360373; ENSG00000158290 [Q13620-1]
ENST00000404115; ENSP00000384109; ENSG00000158290 [Q13620-2]
GeneIDi8450
KEGGihsa:8450
UCSCiuc004esv.4 human [Q13620-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY365125 mRNA Translation: AAR13073.1
AF212995 mRNA Translation: AAK16812.1 Frameshift.
AK123688 mRNA Translation: BAG53936.1
AK299081 mRNA Translation: BAH12944.1
AK315037 mRNA Translation: BAG37520.1
BX537787 mRNA Translation: CAD97843.1
AC002476 Genomic DNA Translation: AAB67315.1 Sequence problems.
AL451005 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11877.1
BC036216 mRNA Translation: AAH36216.1
AB014595 mRNA Translation: BAA31670.2
U58091 mRNA Translation: AAC50548.1
CCDSiCCDS35379.1 [Q13620-2]
CCDS43987.1 [Q13620-1]
RefSeqiNP_001073341.1, NM_001079872.1 [Q13620-1]
NP_003579.3, NM_003588.3 [Q13620-2]
XP_011529702.1, XM_011531400.2 [Q13620-3]
UniGeneiHs.102914

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DO7NMR-A826-913[»]
4A0CX-ray3.80C/E192-913[»]
4A0LX-ray7.40E/H192-913[»]
4A64X-ray2.57A/B/C/D206-557[»]
ProteinModelPortaliQ13620
SMRiQ13620
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114028, 377 interactors
ComplexPortaliCPX-648 CRL4-DDB2 E3 ubiquitin ligase complex, CUL4B variant
CORUMiQ13620
DIPiDIP-31609N
IntActiQ13620, 59 interactors
MINTiQ13620
STRINGi9606.ENSP00000384109

PTM databases

iPTMnetiQ13620
PhosphoSitePlusiQ13620
SwissPalmiQ13620

Polymorphism and mutation databases

BioMutaiCUL4B
DMDMi296439468

Proteomic databases

EPDiQ13620
PaxDbiQ13620
PeptideAtlasiQ13620
PRIDEiQ13620
ProteomicsDBi59611
59612 [Q13620-1]
59613 [Q13620-3]

Protocols and materials databases

DNASUi8450
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371322; ENSP00000360373; ENSG00000158290 [Q13620-1]
ENST00000404115; ENSP00000384109; ENSG00000158290 [Q13620-2]
GeneIDi8450
KEGGihsa:8450
UCSCiuc004esv.4 human [Q13620-2]

Organism-specific databases

CTDi8450
DisGeNETi8450
EuPathDBiHostDB:ENSG00000158290.16
GeneCardsiCUL4B
H-InvDBiHIX0017025
HGNCiHGNC:2555 CUL4B
HPAiCAB017786
HPA003046
HPA011880
HPA058979
MalaCardsiCUL4B
MIMi300304 gene
300354 phenotype
neXtProtiNX_Q13620
OpenTargetsiENSG00000158290
Orphaneti85293 X-linked intellectual disability, Cabezas type
PharmGKBiPA27051
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2167 Eukaryota
COG5647 LUCA
GeneTreeiENSGT00760000119212
HOVERGENiHBG003619
InParanoidiQ13620
KOiK10609
OMAiDFRHKLF
OrthoDBiEOG091G02DP
PhylomeDBiQ13620
TreeFamiTF101153

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-8951664 Neddylation
SIGNORiQ13620

Miscellaneous databases

ChiTaRSiCUL4B human
EvolutionaryTraceiQ13620
GeneWikiiCUL4B
GenomeRNAii8450
PMAP-CutDBiQ13620
PROiPR:Q13620
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158290 Expressed in 232 organ(s), highest expression level in testis
CleanExiHS_CUL4B
ExpressionAtlasiQ13620 baseline and differential
GenevisibleiQ13620 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR033044 CUL4B
IPR016157 Cullin_CS
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR019559 Cullin_neddylation_domain
IPR016159 Cullin_repeat-like_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11932:SF66 PTHR11932:SF66, 1 hit
PfamiView protein in Pfam
PF00888 Cullin, 1 hit
PF10557 Cullin_Nedd8, 1 hit
SMARTiView protein in SMART
SM00182 CULLIN, 1 hit
SM00884 Cullin_Nedd8, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF74788 SSF74788, 1 hit
SSF75632 SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS01256 CULLIN_1, 1 hit
PS50069 CULLIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCUL4B_HUMAN
AccessioniPrimary (citable) accession number: Q13620
Secondary accession number(s): B1APK5
, B3KVX4, B7Z5K8, Q6PIE4, Q6UP07, Q7Z673, Q9BY37, Q9UEB7, Q9UED7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 183 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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