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Entry version 178 (08 May 2019)
Sequence version 3 (19 Jul 2003)
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Protein

Myotubularin-related protein 3

Gene

MTMR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei413Phosphocysteine intermediatePROSITE-ProRule annotationCurated1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei459SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1119 – 1179FYVE-typePROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processLipid metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS02045-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.95 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1632852 Macroautophagy
R-HSA-1660499 Synthesis of PIPs at the plasma membrane

SIGNOR Signaling Network Open Resource

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SIGNORi
Q13615

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001134

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myotubularin-related protein 3 (EC:3.1.3.481 Publication)
Alternative name(s):
FYVE domain-containing dual specificity protein phosphatase 1
Short name:
FYVE-DSP1
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.951 Publication)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.641 Publication)
Zinc finger FYVE domain-containing protein 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTMR3
Synonyms:KIAA0371, ZFYVE10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7451 MTMR3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603558 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13615

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi413C → S: Loss of lipid phosphatase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8897

Open Targets

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OpenTargetsi
ENSG00000100330

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31254

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MTMR3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33112668

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000949361 – 1198Myotubularin-related protein 3Add BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei651PhosphoserineCombined sources1
Modified residuei731PhosphothreonineCombined sources1
Modified residuei906PhosphoserineCombined sources1
Modified residuei909PhosphoserineCombined sources1
Modified residuei1064PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13615

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13615

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13615

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13615

PeptideAtlas

More...
PeptideAtlasi
Q13615

PRoteomics IDEntifications database

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PRIDEi
Q13615

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59601
59602 [Q13615-2]
59603 [Q13615-3]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q13615

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13615

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13615

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100330 Expressed in 225 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13615 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13615 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034515
HPA034516
HPA061399

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114414, 38 interactors

Protein interaction database and analysis system

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IntActi
Q13615, 16 interactors

Molecular INTeraction database

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MINTi
Q13615

STRING: functional protein association networks

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STRINGi
9606.ENSP00000384651

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13615

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini155 – 576Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST422

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni326 – 329Substrate bindingBy similarity4
Regioni351 – 352Substrate bindingBy similarity2
Regioni413 – 419Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1029 – 1062Sequence analysisAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1119 – 1179FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INM7 Eukaryota
ENOG410YU6P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157272

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13615

KEGG Orthology (KO)

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KOi
K18082

Identification of Orthologs from Complete Genome Data

More...
OMAi
RPCLVNS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13615

TreeFam database of animal gene trees

More...
TreeFami
TF315197

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13341 PH-GRAM_MTMR3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035888 MTMR3_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR10807 PTHR10807, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01363 FYVE, 1 hit
PF06602 Myotub-related, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064 FYVE, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52799 SSF52799, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: Q13615-1) [UniParc]FASTAAdd to basket
Also known as: FYVE-DSP1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEETRHSLE CIQANQIFPR KQLIREDENL QVPFLELHGE STEFVGRAED
60 70 80 90 100
AIIALSNYRL HIKFKESLVN VPLQLIESVE CRDIFQLHLT CKDCKVIRCQ
110 120 130 140 150
FSTFEQCQEW LKRLNNAIRP PAKIEDLFSF AYHAWCMEVY ASEKEQHGDL
160 170 180 190 200
CRPGEHVTSR FKNEVERMGF DMNNAWRISN INEKYKLCGS YPQELIVPAW
210 220 230 240 250
ITDKELESVS SFRSWKRIPA VIYRHQSNGA VIARCGQPEV SWWGWRNADD
260 270 280 290 300
EHLVQSVAKA CASDSRSSGS KLSTRNTSRD FPNGGDLSDV EFDSSLSNAS
310 320 330 340 350
GAESLAIQPQ KLLILDARSY AAAVANRAKG GGCECPEYYP NCEVVFMGMA
360 370 380 390 400
NIHSIRRSFQ SLRLLCTQMP DPGNWLSALE STKWLHHLSV LLKSALLVVH
410 420 430 440 450
AVDQDQRPVL VHCSDGWDRT PQIVALAKLL LDPYYRTIEG FQVLVEMEWL
460 470 480 490 500
DFGHKFADRC GHGENSDDLN ERCPVFLQWL DCVHQLQRQF PCSFEFNEAF
510 520 530 540 550
LVKLVQHTYS CLFGTFLCNN AKERGEKHTQ ERTCSVWSLL RAGNKAFKNL
560 570 580 590 600
LYSSQSEAVL YPVCHVRNLM LWSAVYLPCP SPTTPVDDSC APYPAPGTSP
610 620 630 640 650
DDPPLSRLPK TRSYDNLTTA CDNTVPLASR RCSDPSLNEK WQEHRRSLEL
660 670 680 690 700
SSLAGPGEDP LSADSLGKPT RVPGGAELSV AAGVAEGQME NILQEATKEE
710 720 730 740 750
SGVEEPAHRA GIEIQEGKED PLLEKESRRK TPEASAIGLH QDPELGDAAL
760 770 780 790 800
RSHLDMSWPL FSQGISEQQS GLSVLLSSLQ VPPRGEDSLE VPVEQFRIEE
810 820 830 840 850
IAEGREEAVL PIPVDAKVGY GTSQSCSLLP SQVPFETRGP NVDSSTDMLV
860 870 880 890 900
EDKVKSVSGP QGHHRSCLVN SGKDRLPQTM EPSPSETSLV ERPQVGSVVH
910 920 930 940 950
RTSLGSTLSL TRSPCALPLA ECKEGLVCNG APETENRASE QPPGLSTLQM
960 970 980 990 1000
YPTPNGHCAN GEAGRSKDSL SRQLSAMSCS SAHLHSRNLH HKWLHSHSGR
1010 1020 1030 1040 1050
PSATSSPDQP SRSHLDDDGM SVYTDTIQQR LRQIESGHQQ EVETLKKQVQ
1060 1070 1080 1090 1100
ELKSRLESQY LTSSLHFNGD FGDEVTSIPD SESNLDQNCL SRCSTEIFSE
1110 1120 1130 1140 1150
ASWEQVDKQD TEMTRWLPDH LAAHCYACDS AFWLASRKHH CRNCGNVFCS
1160 1170 1180 1190
SCCNQKVPVP SQQLFEPSRV CKSCYSSLHP TSSSIDLELD KPIAATSN
Length:1,198
Mass (Da):133,619
Last modified:July 19, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE6F4B165074D5F8
GO
Isoform A (identifier: Q13615-2) [UniParc]FASTAAdd to basket
Also known as: FYVE-DSP1a

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1112: Missing.
     1142-1142: R → RDTDRVDQTW

Show »
Length:1,170
Mass (Da):130,561
Checksum:iB51B10E3E7245433
GO
Isoform C (identifier: Q13615-3) [UniParc]FASTAAdd to basket
Also known as: FYVE-DSP1c

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1112: Missing.

Show »
Length:1,161
Mass (Da):129,444
Checksum:i18C795D42EFB1177
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E953G5E953_HUMAN
Myotubularin related protein 3, iso...
MTMR3 hCG_41636
1,062Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLU3C9JLU3_HUMAN
Myotubularin-related protein 3
MTMR3
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20826 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti560 – 578LYPVC…AVYLP → CILQPFHCGQQKEFGVGYI (PubMed:9736772).CuratedAdd BLAST19

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035656221V → L in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0077811076 – 1112Missing in isoform A and isoform C. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_0077821142R → RDTDRVDQTW in isoform A. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF233436 mRNA Translation: AAF40203.2
AF233437 mRNA Translation: AAF40204.1
AF233438 mRNA Translation: AAF40205.1
AB002369 mRNA Translation: BAA20826.2 Different initiation.
CR456525 mRNA Translation: CAG30411.1
CH471095 Genomic DNA Translation: EAW59852.1
CH471095 Genomic DNA Translation: EAW59855.1
BC142713 mRNA Translation: AAI42714.1
BC148216 mRNA Translation: AAI48217.1
BC152455 mRNA Translation: AAI52456.1
AC003071 Genomic DNA Translation: AAB83949.1
U58034 Genomic DNA Translation: AAC79119.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13870.1 [Q13615-1]
CCDS13871.1 [Q13615-2]
CCDS46682.1 [Q13615-3]

NCBI Reference Sequences

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RefSeqi
NP_066576.1, NM_021090.3 [Q13615-1]
NP_694690.1, NM_153050.2 [Q13615-2]
NP_694691.1, NM_153051.2 [Q13615-3]
XP_016884521.1, XM_017029032.1 [Q13615-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000333027; ENSP00000331649; ENSG00000100330 [Q13615-2]
ENST00000351488; ENSP00000307271; ENSG00000100330 [Q13615-3]
ENST00000401950; ENSP00000384651; ENSG00000100330 [Q13615-1]
ENST00000406629; ENSP00000384077; ENSG00000100330 [Q13615-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8897

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8897

UCSC genome browser

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UCSCi
uc003agu.5 human [Q13615-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233436 mRNA Translation: AAF40203.2
AF233437 mRNA Translation: AAF40204.1
AF233438 mRNA Translation: AAF40205.1
AB002369 mRNA Translation: BAA20826.2 Different initiation.
CR456525 mRNA Translation: CAG30411.1
CH471095 Genomic DNA Translation: EAW59852.1
CH471095 Genomic DNA Translation: EAW59855.1
BC142713 mRNA Translation: AAI42714.1
BC148216 mRNA Translation: AAI48217.1
BC152455 mRNA Translation: AAI52456.1
AC003071 Genomic DNA Translation: AAB83949.1
U58034 Genomic DNA Translation: AAC79119.1
CCDSiCCDS13870.1 [Q13615-1]
CCDS13871.1 [Q13615-2]
CCDS46682.1 [Q13615-3]
RefSeqiNP_066576.1, NM_021090.3 [Q13615-1]
NP_694690.1, NM_153050.2 [Q13615-2]
NP_694691.1, NM_153051.2 [Q13615-3]
XP_016884521.1, XM_017029032.1 [Q13615-3]

3D structure databases

SMRiQ13615
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114414, 38 interactors
IntActiQ13615, 16 interactors
MINTiQ13615
STRINGi9606.ENSP00000384651

Chemistry databases

SwissLipidsiSLP:000001134

PTM databases

DEPODiQ13615
iPTMnetiQ13615
PhosphoSitePlusiQ13615

Polymorphism and mutation databases

BioMutaiMTMR3
DMDMi33112668

Proteomic databases

EPDiQ13615
jPOSTiQ13615
MaxQBiQ13615
PaxDbiQ13615
PeptideAtlasiQ13615
PRIDEiQ13615
ProteomicsDBi59601
59602 [Q13615-2]
59603 [Q13615-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8897
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333027; ENSP00000331649; ENSG00000100330 [Q13615-2]
ENST00000351488; ENSP00000307271; ENSG00000100330 [Q13615-3]
ENST00000401950; ENSP00000384651; ENSG00000100330 [Q13615-1]
ENST00000406629; ENSP00000384077; ENSG00000100330 [Q13615-2]
GeneIDi8897
KEGGihsa:8897
UCSCiuc003agu.5 human [Q13615-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8897
DisGeNETi8897

GeneCards: human genes, protein and diseases

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GeneCardsi
MTMR3
HGNCiHGNC:7451 MTMR3
HPAiHPA034515
HPA034516
HPA061399
MIMi603558 gene
neXtProtiNX_Q13615
OpenTargetsiENSG00000100330
PharmGKBiPA31254

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INM7 Eukaryota
ENOG410YU6P LUCA
GeneTreeiENSGT00940000157272
InParanoidiQ13615
KOiK18082
OMAiRPCLVNS
PhylomeDBiQ13615
TreeFamiTF315197

Enzyme and pathway databases

BioCyciMetaCyc:HS02045-MONOMER
BRENDAi3.1.3.95 2681
ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
SIGNORiQ13615

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MTMR3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MTMR3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8897

Protein Ontology

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PROi
PR:Q13615

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100330 Expressed in 225 organ(s), highest expression level in oocyte
ExpressionAtlasiQ13615 baseline and differential
GenevisibleiQ13615 HS

Family and domain databases

CDDicd13341 PH-GRAM_MTMR3, 1 hit
Gene3Di3.30.40.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR035888 MTMR3_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10807 PTHR10807, 1 hit
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTMR3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13615
Secondary accession number(s): A5PL26
, A7MD32, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2003
Last modified: May 8, 2019
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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