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UniProtKB - Q13614 (MTMR2_HUMAN)

Entry version 210 (23 Feb 2022)
Sequence version 4 (04 Nov 2008)
Previous versions | rss
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Protein

Myotubularin-related protein 2

Gene

MTMR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11733541, PubMed:12668758, PubMed:21372139, PubMed:14690594).

Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (By similarity).

Stabilizes SBF2/MTMR13 at the membranes (By similarity).

Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity).

By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Interaction with SBF1/MTMR5 increases phosphatase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei417Phosphocysteine intermediate2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei463Substrate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.64, 2681
3.1.3.95, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13614

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1483248, Synthesis of PIPs at the ER membrane
R-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-1660516, Synthesis of PIPs at the early endosome membrane
R-HSA-1660517, Synthesis of PIPs at the late endosome membrane

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13614

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001135

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myotubularin-related protein 2Curated
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.953 Publications)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.644 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTMR2Imported
Synonyms:KIAA1073
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7450, MTMR2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603557, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13614

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000087053

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Charcot-Marie-Tooth disease 4B1 (CMT4B1)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047947283R → W in CMT4B1. 1 PublicationCorresponds to variant dbSNP:rs1590983932EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi417C → S: Loss of activity. 2 Publications1
Mutagenesisi419D → A: No effect. 1 Publication1
Mutagenesisi422D → A: Loss of activity. 1 Publication1
Mutagenesisi589 – 643Missing : Loss of homodimerization and interaction with SBF1. 1 PublicationAdd BLAST55
Mutagenesisi607L → Y: Reduces homodimerization and interaction with SBF1. 1 Publication1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...DisGeNETi		8898

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		MTMR2

MalaCards human disease database

More...MalaCardsi		MTMR2
MIMi601382, phenotype

Open Targets

More...OpenTargetsi		ENSG00000087053

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		99955, Charcot-Marie-Tooth disease type 4B1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31253

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13614, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MTMR2

Domain mapping of disease mutations (DMDM)

More...DMDMi		212276520

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000949341 – 643Myotubularin-related protein 2Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei58PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13614

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13614

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13614

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13614

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13614

PeptideAtlas

More...PeptideAtlasi		Q13614

PRoteomics IDEntifications database

More...PRIDEi		Q13614

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1592
59600 [Q13614-1]

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		MTMR2

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q13614, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13614

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q13614

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13614

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q13614

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000087053, Expressed in testis and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13614, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13614, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000087053, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (via coiled-coil domain) (PubMed:12668758, PubMed:15998640). Heterotetramer consisting of one MTMR2 dimer and one SBF2/MTMR13 dimer (PubMed:15998640). Heterodimer with SBF1/MTMR5 (PubMed:12668758, PubMed:21372139). Heterodimer with MTMR12 (PubMed:12847286).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114415, 55 interactors

Protein interaction database and analysis system

More...IntActi		Q13614, 12 interactors

Molecular INTeraction database

More...MINTi		Q13614

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000345752

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13614, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1643
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13614

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13614

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini68 – 139GRAMSequence analysisAdd BLAST72
Domaini205 – 580Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST376

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 56DisorderedSequence analysisAdd BLAST56
Regioni330 – 333Substrate binding1 Publication4
Regioni355 – 356Substrate binding1 Publication2
Regioni417 – 423Substrate binding1 Publication7
Regioni615 – 643DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili593 – 6271 PublicationAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 56Polar residuesSequence analysisAdd BLAST38
Compositional biasi618 – 643Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil domain mediates homodimerization (PubMed:12668758, PubMed:15998640). Also mediates interaction with SBF1/MTMR5 (PubMed:12668758). By mediating MTMR2 homodimerization, indirectly involved in SBF2/MTMR13 and MTMR2 heterotetramerization (By similarity).By similarity2 Publications
The GRAM domain mediates binding to phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4471, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153669

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13614

Identification of Orthologs from Complete Genome Data

More...OMAi		ESYAICD

Database of Orthologous Groups

More...OrthoDBi		824298at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13614

TreeFam database of animal gene trees

More...TreeFami		TF315197

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004182, GRAM
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR011993, PH-like_dom_sf
IPR029021, Prot-tyrosine_phosphatase-like
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, Tyr_Pase_dom

The PANTHER Classification System

More...PANTHERi		PTHR10807, PTHR10807, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02893, GRAM, 1 hit
PF06602, Myotub-related, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00568, GRAM, 1 hit
SM00404, PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51339, PPASE_MYOTUBULARIN, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13614-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKSSSCESL GSQPAAARPP SVDSLSSAST SHSENSVHTK SASVVSSDSI 
        60         70         80         90        100
STSADNFSPD LRVLRESNKL AEMEEPPLLP GENIKDMAKD VTYICPFTGA 
       110        120        130        140        150
VRGTLTVTNY RLYFKSMERD PPFVLDASLG VINRVEKIGG ASSRGENSYG 
       160        170        180        190        200
LETVCKDIRN LRFAHKPEGR TRRSIFENLM KYAFPVSNNL PLFAFEYKEV 
       210        220        230        240        250
FPENGWKLYD PLLEYRRQGI PNESWRITKI NERYELCDTY PALLVVPANI 
       260        270        280        290        300
PDEELKRVAS FRSRGRIPVL SWIHPESQAT ITRCSQPMVG VSGKRSKEDE 
       310        320        330        340        350
KYLQAIMDSN AQSHKIFIFD ARPSVNAVAN KAKGGGYESE DAYQNAELVF 
       360        370        380        390        400
LDIHNIHVMR ESLRKLKEIV YPNIEETHWL SNLESTHWLE HIKLILAGAL 
       410        420        430        440        450
RIADKVESGK TSVVVHCSDG WDRTAQLTSL AMLMLDGYYR TIRGFEVLVE 
       460        470        480        490        500
KEWLSFGHRF QLRVGHGDKN HADADRSPVF LQFIDCVWQM TRQFPTAFEF 
       510        520        530        540        550
NEYFLITILD HLYSCLFGTF LCNSEQQRGK ENLPKRTVSL WSYINSQLED 
       560        570        580        590        600
FTNPLYGSYS NHVLYPVASM RHLELWVGYY IRWNPRMKPQ EPIHNRYKEL 
       610        620        630        640 
LAKRAELQKK VEELQREISN RSTSSSERAS SPAQCVTPVQ TVV
Length:643
Mass (Da):73,381
Last modified:November 4, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10FD6508D0CDA719
GO
Isoform 2 (identifier: Q13614-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Show »
Length:571
Mass (Da):65,959
Checksum:iDBC304269CEFC843
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JEX3C9JEX3_HUMAN
Phosphatidylinositol-3,5-bisphospha...
MTMR2
556Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGS5A0A6Q8PGS5_HUMAN
Phosphatidylinositol-3,5-bisphospha...
MTMR2
540Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHL9A0A6Q8PHL9_HUMAN
Phosphatidylinositol-3,5-bisphospha...
MTMR2
581Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHS7A0A6Q8PHS7_HUMAN
Phosphatidylinositol-3,5-bisphospha...
MTMR2
527Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGV9A0A6Q8PGV9_HUMAN
Myotubularin-related protein 2
MTMR2
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PFL3A0A6Q8PFL3_HUMAN
Myotubularin-related protein 2
MTMR2
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PF46A0A6Q8PF46_HUMAN
Myotubularin-related protein 2
MTMR2
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PG25A0A6Q8PG25_HUMAN
Myotubularin-related protein 2
MTMR2
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGT1A0A6Q8PGT1_HUMAN
Myotubularin-related protein 2
MTMR2
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHC4A0A6Q8PHC4_HUMAN
Myotubularin-related protein 2
MTMR2
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83025 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0472553K → T2 PublicationsCorresponds to variant dbSNP:rs3824874EnsemblClinVar.1
Natural variantiVAR_047947283R → W in CMT4B1. 1 PublicationCorresponds to variant dbSNP:rs1590983932EnsemblClinVar.1
Natural variantiVAR_047256545N → S. Corresponds to variant dbSNP:rs558018EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0449331 – 72Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB028996 mRNA Translation: BAA83025.2 Different initiation.
AK302940 mRNA Translation: BAG64098.1
AP000870 Genomic DNA No translation available.
AP001877 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66971.1
BC052990 mRNA Translation: AAH52990.1
U58033 mRNA Translation: AAC79118.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8305.1 [Q13614-1]
CCDS8306.1 [Q13614-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T09497

NCBI Reference Sequences

More...RefSeqi		NP_001230500.1, NM_001243571.1 [Q13614-2]
NP_057240.3, NM_016156.5 [Q13614-1]
NP_958435.1, NM_201278.2 [Q13614-2]
NP_958438.1, NM_201281.2 [Q13614-2]
XP_005274431.1, XM_005274374.2 [Q13614-2]
XP_005274432.1, XM_005274375.2 [Q13614-2]
XP_006718997.1, XM_006718934.2
XP_006718998.1, XM_006718935.2
XP_006718999.1, XM_006718936.3
XP_016874006.1, XM_017018517.1
XP_016874007.1, XM_017018518.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000346299; ENSP00000345752; ENSG00000087053
ENST00000352297; ENSP00000343737; ENSG00000087053 [Q13614-2]
ENST00000393223; ENSP00000376915; ENSG00000087053 [Q13614-2]
ENST00000409459; ENSP00000386882; ENSG00000087053 [Q13614-2]
ENST00000444541; ENSP00000396020; ENSG00000087053 [Q13614-2]
ENST00000470293; ENSP00000502515; ENSG00000087053 [Q13614-2]
ENST00000481642; ENSP00000502505; ENSG00000087053 [Q13614-2]
ENST00000484818; ENSP00000501963; ENSG00000087053 [Q13614-2]
ENST00000495134; ENSP00000501894; ENSG00000087053 [Q13614-2]
ENST00000497683; ENSP00000501753; ENSG00000087053 [Q13614-2]
ENST00000674528; ENSP00000501567; ENSG00000087053 [Q13614-2]
ENST00000674610; ENSP00000501688; ENSG00000087053 [Q13614-2]
ENST00000674924; ENSP00000502433; ENSG00000087053 [Q13614-2]
ENST00000674968; ENSP00000502567; ENSG00000087053 [Q13614-2]
ENST00000674989; ENSP00000502829; ENSG00000087053 [Q13614-2]
ENST00000675174; ENSP00000502032; ENSG00000087053 [Q13614-2]
ENST00000675196; ENSP00000501867; ENSG00000087053 [Q13614-2]
ENST00000675362; ENSP00000501989; ENSG00000087053 [Q13614-2]
ENST00000675454; ENSP00000501781; ENSG00000087053 [Q13614-2]
ENST00000675477; ENSP00000501751; ENSG00000087053 [Q13614-2]
ENST00000675489; ENSP00000501702; ENSG00000087053 [Q13614-2]
ENST00000675636; ENSP00000501850; ENSG00000087053 [Q13614-2]
ENST00000675652; ENSP00000502694; ENSG00000087053 [Q13614-2]
ENST00000675933; ENSP00000502575; ENSG00000087053 [Q13614-2]
ENST00000675981; ENSP00000502204; ENSG00000087053 [Q13614-2]
ENST00000676166; ENSP00000501632; ENSG00000087053 [Q13614-2]
ENST00000676261; ENSP00000501675; ENSG00000087053 [Q13614-2]
ENST00000676272; ENSP00000501601; ENSG00000087053 [Q13614-2]
ENST00000676378; ENSP00000502736; ENSG00000087053 [Q13614-2]
ENST00000676440; ENSP00000501926; ENSG00000087053 [Q13614-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8898

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000346299.10; ENSP00000345752.6; NM_016156.6; NP_057240.3

UCSC genome browser

More...UCSCi		uc001pft.4, human [Q13614-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Inherited peripheral neuropathies mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028996 mRNA Translation: BAA83025.2 Different initiation.
AK302940 mRNA Translation: BAG64098.1
AP000870 Genomic DNA No translation available.
AP001877 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66971.1
BC052990 mRNA Translation: AAH52990.1
U58033 mRNA Translation: AAC79118.1
CCDSiCCDS8305.1 [Q13614-1]
CCDS8306.1 [Q13614-2]
PIRiT09497
RefSeqiNP_001230500.1, NM_001243571.1 [Q13614-2]
NP_057240.3, NM_016156.5 [Q13614-1]
NP_958435.1, NM_201278.2 [Q13614-2]
NP_958438.1, NM_201281.2 [Q13614-2]
XP_005274431.1, XM_005274374.2 [Q13614-2]
XP_005274432.1, XM_005274375.2 [Q13614-2]
XP_006718997.1, XM_006718934.2
XP_006718998.1, XM_006718935.2
XP_006718999.1, XM_006718936.3
XP_016874006.1, XM_017018517.1
XP_016874007.1, XM_017018518.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LW3X-ray2.30A1-643[»]
1M7RX-ray2.60A/B1-643[»]
1ZSQX-ray1.82A73-586[»]
1ZVRX-ray1.98A73-586[»]
5GNHX-ray2.60A/B73-643[»]
SMRiQ13614
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114415, 55 interactors
IntActiQ13614, 12 interactors
MINTiQ13614
STRINGi9606.ENSP00000345752

Chemistry databases

SwissLipidsiSLP:000001135

PTM databases

DEPODiMTMR2
GlyGeniQ13614, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ13614
MetOSiteiQ13614
PhosphoSitePlusiQ13614
SwissPalmiQ13614

Genetic variation databases

BioMutaiMTMR2
DMDMi212276520

Proteomic databases

EPDiQ13614
jPOSTiQ13614
MassIVEiQ13614
MaxQBiQ13614
PaxDbiQ13614
PeptideAtlasiQ13614
PRIDEiQ13614
ProteomicsDBi1592
59600 [Q13614-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31676, 254 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		8898

Genome annotation databases

EnsembliENST00000346299; ENSP00000345752; ENSG00000087053
ENST00000352297; ENSP00000343737; ENSG00000087053 [Q13614-2]
ENST00000393223; ENSP00000376915; ENSG00000087053 [Q13614-2]
ENST00000409459; ENSP00000386882; ENSG00000087053 [Q13614-2]
ENST00000444541; ENSP00000396020; ENSG00000087053 [Q13614-2]
ENST00000470293; ENSP00000502515; ENSG00000087053 [Q13614-2]
ENST00000481642; ENSP00000502505; ENSG00000087053 [Q13614-2]
ENST00000484818; ENSP00000501963; ENSG00000087053 [Q13614-2]
ENST00000495134; ENSP00000501894; ENSG00000087053 [Q13614-2]
ENST00000497683; ENSP00000501753; ENSG00000087053 [Q13614-2]
ENST00000674528; ENSP00000501567; ENSG00000087053 [Q13614-2]
ENST00000674610; ENSP00000501688; ENSG00000087053 [Q13614-2]
ENST00000674924; ENSP00000502433; ENSG00000087053 [Q13614-2]
ENST00000674968; ENSP00000502567; ENSG00000087053 [Q13614-2]
ENST00000674989; ENSP00000502829; ENSG00000087053 [Q13614-2]
ENST00000675174; ENSP00000502032; ENSG00000087053 [Q13614-2]
ENST00000675196; ENSP00000501867; ENSG00000087053 [Q13614-2]
ENST00000675362; ENSP00000501989; ENSG00000087053 [Q13614-2]
ENST00000675454; ENSP00000501781; ENSG00000087053 [Q13614-2]
ENST00000675477; ENSP00000501751; ENSG00000087053 [Q13614-2]
ENST00000675489; ENSP00000501702; ENSG00000087053 [Q13614-2]
ENST00000675636; ENSP00000501850; ENSG00000087053 [Q13614-2]
ENST00000675652; ENSP00000502694; ENSG00000087053 [Q13614-2]
ENST00000675933; ENSP00000502575; ENSG00000087053 [Q13614-2]
ENST00000675981; ENSP00000502204; ENSG00000087053 [Q13614-2]
ENST00000676166; ENSP00000501632; ENSG00000087053 [Q13614-2]
ENST00000676261; ENSP00000501675; ENSG00000087053 [Q13614-2]
ENST00000676272; ENSP00000501601; ENSG00000087053 [Q13614-2]
ENST00000676378; ENSP00000502736; ENSG00000087053 [Q13614-2]
ENST00000676440; ENSP00000501926; ENSG00000087053 [Q13614-2]
GeneIDi8898
KEGGihsa:8898
MANE-SelectiENST00000346299.10; ENSP00000345752.6; NM_016156.6; NP_057240.3
UCSCiuc001pft.4, human [Q13614-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8898
DisGeNETi8898

GeneCards: human genes, protein and diseases

More...GeneCardsi		MTMR2
GeneReviewsiMTMR2
HGNCiHGNC:7450, MTMR2
HPAiENSG00000087053, Low tissue specificity
MalaCardsiMTMR2
MIMi601382, phenotype
603557, gene
neXtProtiNX_Q13614
OpenTargetsiENSG00000087053
Orphaneti99955, Charcot-Marie-Tooth disease type 4B1
PharmGKBiPA31253
VEuPathDBiHostDB:ENSG00000087053

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4471, Eukaryota
GeneTreeiENSGT00940000153669
InParanoidiQ13614
OMAiESYAICD
OrthoDBi824298at2759
PhylomeDBiQ13614
TreeFamiTF315197

Enzyme and pathway databases

BRENDAi3.1.3.64, 2681
3.1.3.95, 2681
PathwayCommonsiQ13614
ReactomeiR-HSA-1483248, Synthesis of PIPs at the ER membrane
R-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-1660516, Synthesis of PIPs at the early endosome membrane
R-HSA-1660517, Synthesis of PIPs at the late endosome membrane
SignaLinkiQ13614

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8898, 11 hits in 1052 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MTMR2, human
EvolutionaryTraceiQ13614

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MTMR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8898
PharosiQ13614, Tbio

Protein Ontology

More...PROi		PR:Q13614
RNActiQ13614, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000087053, Expressed in testis and 237 other tissues
ExpressionAtlasiQ13614, baseline and differential
GenevisibleiQ13614, HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182, GRAM
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR011993, PH-like_dom_sf
IPR029021, Prot-tyrosine_phosphatase-like
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, Tyr_Pase_dom
PANTHERiPTHR10807, PTHR10807, 1 hit
PfamiView protein in Pfam
PF02893, GRAM, 1 hit
PF06602, Myotub-related, 1 hit
SMARTiView protein in SMART
SM00568, GRAM, 1 hit
SM00404, PTPc_motif, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339, PPASE_MYOTUBULARIN, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTMR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13614
Secondary accession number(s): A6NN98, Q9UPS9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 4, 2008
Last modified: February 23, 2022
This is version 210 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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