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Protein

KRR1 small subunit processome component homolog

Gene

KRR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
KRR1 small subunit processome component homolog
Alternative name(s):
HIV-1 Rev-binding protein 2
KRR-R motif-containing protein 1
Rev-interacting protein 1
Short name:
Rip-1
Gene namesi
Name:KRR1
Synonyms:HRB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111615.12
HGNCiHGNC:5176 KRR1
MIMi612817 gene
neXtProtiNX_Q13601

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11103
OpenTargetsiENSG00000111615
PharmGKBiPA29450

Polymorphism and mutation databases

BioMutaiKRR1
DMDMi50400303

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000501142 – 381KRR1 small subunit processome component homologAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei3PhosphoserineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki340Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki369Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13601
MaxQBiQ13601
PaxDbiQ13601
PeptideAtlasiQ13601
PRIDEiQ13601
ProteomicsDBi59591
59592 [Q13601-2]

2D gel databases

SWISS-2DPAGEiQ13601

PTM databases

iPTMnetiQ13601
PhosphoSitePlusiQ13601
SwissPalmiQ13601

Miscellaneous databases

PMAP-CutDBiQ13601

Expressioni

Gene expression databases

BgeeiENSG00000111615 Expressed in 233 organ(s), highest expression level in oocyte
CleanExiHS_KRR1
GenevisibleiQ13601 HS

Organism-specific databases

HPAiHPA043433
HPA051690

Interactioni

Subunit structurei

Component of the ribosomal small subunit (SSU) processome (By similarity). Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZBP1Q9H1713EBI-744525,EBI-6264672

Protein-protein interaction databases

BioGridi116284, 82 interactors
IntActiQ13601, 24 interactors
MINTiQ13601
STRINGi9606.ENSP00000229214

Structurei

3D structure databases

ProteinModelPortaliQ13601
SMRiQ13601
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 206KHAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi247 – 381Lys-richAdd BLAST135

Sequence similaritiesi

Belongs to the KRR1 family.Curated

Phylogenomic databases

eggNOGiKOG2874 Eukaryota
COG1094 LUCA
GeneTreeiENSGT00390000018775
HOGENOMiHOG000116208
HOVERGENiHBG051924
InParanoidiQ13601
KOiK06961
OMAiVSVMGPY
OrthoDBiEOG091G0BTX
PhylomeDBiQ13601
TreeFamiTF105745

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR036612 KH_dom_type_1_sf
IPR024166 rRNA_assembly_KRR1
PANTHERiPTHR12581 PTHR12581, 1 hit
PIRSFiPIRSF006515 KRR1, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13601-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPSLERPE KGAGKSEFRN QKPKPENQDE SELLTVPDGW KEPAFSKEDN
60 70 80 90 100
PRGLLEESSF ATLFPKYREA YLKECWPLVQ KALNEHHVNA TLDLIEGSMT
110 120 130 140 150
VCTTKKTFDP YIIIRARDLI KLLARSVSFE QAVRILQDDV ACDIIKIGSL
160 170 180 190 200
VRNKERFVKR RQRLIGPKGS TLKALELLTN CYIMVQGNTV SAIGPFSGLK
210 220 230 240 250
EVRKVVLDTM KNIHPIYNIK SLMIKRELAK DSELRSQSWE RFLPQFKHKN
260 270 280 290 300
VNKRKEPKKK TVKKEYTPFP PPQPESQIDK ELASGEYFLK ANQKKRQKME
310 320 330 340 350
AIKAKQAEAI SKRQEERNKA FIPPKEKPIV KPKEASTETK IDVASIKEKV
360 370 380
KKAKNKKLGA LTAEEIALKM EADEKKKKKK K
Length:381
Mass (Da):43,665
Last modified:January 23, 2007 - v4
Checksum:i8F242FCC36BF079B
GO
Isoform 2 (identifier: Q13601-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-277: Missing.

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):36,788
Checksum:iFE9A271F5ABBBB6F
GO

Sequence cautioni

The sequence AAB00557 differs from that shown. Reason: Frameshift at positions 265 and 300.Curated
The sequence AAH05225 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13A → V in ABJ97679 (Ref. 1) Curated1
Sequence conflicti57E → K in BAG36436 (PubMed:14702039).Curated1
Sequence conflicti69E → G in AAH16778 (PubMed:15489334).Curated1
Sequence conflicti161R → G in ABJ97679 (Ref. 1) Curated1
Sequence conflicti165I → V in ABJ97679 (Ref. 1) Curated1
Sequence conflicti206V → A in AAH26107 (PubMed:15489334).Curated1
Sequence conflicti275E → G in AAH33887 (PubMed:15489334).Curated1
Sequence conflicti339T → A in ABJ97679 (Ref. 1) Curated1
Sequence conflicti339T → A in AAH33887 (PubMed:15489334).Curated1
Sequence conflicti353A → G in AAH05225 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049680134R → Q. Corresponds to variant dbSNP:rs11540407Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042223221 – 277Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF010919 mRNA Translation: ABJ97679.1
AK313687 mRNA Translation: BAG36436.1
AC022507 Genomic DNA No translation available.
AC121761 Genomic DNA No translation available.
BC005225 mRNA Translation: AAH05225.1 Sequence problems.
BC016778 mRNA Translation: AAH16778.1
BC026107 mRNA Translation: AAH26107.1
BC033887 mRNA Translation: AAH33887.1
U55766 mRNA Translation: AAB00557.1 Frameshift.
CCDSiCCDS9012.1 [Q13601-1]
PIRiG02629
RefSeqiNP_008974.5, NM_007043.6 [Q13601-1]
UniGeneiHs.645517

Genome annotation databases

EnsembliENST00000229214; ENSP00000229214; ENSG00000111615 [Q13601-1]
ENST00000438169; ENSP00000411740; ENSG00000111615 [Q13601-2]
GeneIDi11103
KEGGihsa:11103
UCSCiuc001sxt.4 human [Q13601-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF010919 mRNA Translation: ABJ97679.1
AK313687 mRNA Translation: BAG36436.1
AC022507 Genomic DNA No translation available.
AC121761 Genomic DNA No translation available.
BC005225 mRNA Translation: AAH05225.1 Sequence problems.
BC016778 mRNA Translation: AAH16778.1
BC026107 mRNA Translation: AAH26107.1
BC033887 mRNA Translation: AAH33887.1
U55766 mRNA Translation: AAB00557.1 Frameshift.
CCDSiCCDS9012.1 [Q13601-1]
PIRiG02629
RefSeqiNP_008974.5, NM_007043.6 [Q13601-1]
UniGeneiHs.645517

3D structure databases

ProteinModelPortaliQ13601
SMRiQ13601
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116284, 82 interactors
IntActiQ13601, 24 interactors
MINTiQ13601
STRINGi9606.ENSP00000229214

PTM databases

iPTMnetiQ13601
PhosphoSitePlusiQ13601
SwissPalmiQ13601

Polymorphism and mutation databases

BioMutaiKRR1
DMDMi50400303

2D gel databases

SWISS-2DPAGEiQ13601

Proteomic databases

EPDiQ13601
MaxQBiQ13601
PaxDbiQ13601
PeptideAtlasiQ13601
PRIDEiQ13601
ProteomicsDBi59591
59592 [Q13601-2]

Protocols and materials databases

DNASUi11103
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229214; ENSP00000229214; ENSG00000111615 [Q13601-1]
ENST00000438169; ENSP00000411740; ENSG00000111615 [Q13601-2]
GeneIDi11103
KEGGihsa:11103
UCSCiuc001sxt.4 human [Q13601-1]

Organism-specific databases

CTDi11103
DisGeNETi11103
EuPathDBiHostDB:ENSG00000111615.12
GeneCardsiKRR1
H-InvDBiHIX0010835
HGNCiHGNC:5176 KRR1
HPAiHPA043433
HPA051690
MIMi612817 gene
neXtProtiNX_Q13601
OpenTargetsiENSG00000111615
PharmGKBiPA29450
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2874 Eukaryota
COG1094 LUCA
GeneTreeiENSGT00390000018775
HOGENOMiHOG000116208
HOVERGENiHBG051924
InParanoidiQ13601
KOiK06961
OMAiVSVMGPY
OrthoDBiEOG091G0BTX
PhylomeDBiQ13601
TreeFamiTF105745

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiKRR1 human
GeneWikiiKRR1
GenomeRNAii11103
PMAP-CutDBiQ13601
PROiPR:Q13601
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111615 Expressed in 233 organ(s), highest expression level in oocyte
CleanExiHS_KRR1
GenevisibleiQ13601 HS

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR036612 KH_dom_type_1_sf
IPR024166 rRNA_assembly_KRR1
PANTHERiPTHR12581 PTHR12581, 1 hit
PIRSFiPIRSF006515 KRR1, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKRR1_HUMAN
AccessioniPrimary (citable) accession number: Q13601
Secondary accession number(s): A0FIK6
, A0JLP0, B2R989, E7EUQ0, Q8NEA8, Q8TC37, Q96AT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 155 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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