UniProtKB - Q13601 (KRR1_HUMAN)
Protein
KRR1 small subunit processome component homolog
Gene
KRR1
Organism
Homo sapiens (Human)
Status
Functioni
Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).By similarity
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- rRNA processing Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | Ribosome biogenesis, rRNA processing |
Enzyme and pathway databases
PathwayCommonsi | Q13601 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: KRR1 small subunit processome component homologAlternative name(s): HIV-1 Rev-binding protein 2 KRR-R motif-containing protein 1 Rev-interacting protein 1 Short name: Rip-1 |
Gene namesi | Name:KRR1 Synonyms:HRB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000111615.12 |
HGNCi | HGNC:5176, KRR1 |
MIMi | 612817, gene |
neXtProti | NX_Q13601 |
Subcellular locationi
Extracellular region or secreted
- intercellular bridge Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 11103 |
OpenTargetsi | ENSG00000111615 |
PharmGKBi | PA29450 |
Miscellaneous databases
Pharosi | Q13601, Tbio |
Polymorphism and mutation databases
BioMutai | KRR1 |
DMDMi | 50400303 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000050114 | 2 – 381 | KRR1 small subunit processome component homologAdd BLAST | 380 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 3 | PhosphoserineCombined sources | 1 | |
Modified residuei | 5 | PhosphoserineCombined sources | 1 | |
Cross-linki | 24 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 340 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 369 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q13601 |
jPOSTi | Q13601 |
MassIVEi | Q13601 |
MaxQBi | Q13601 |
PaxDbi | Q13601 |
PeptideAtlasi | Q13601 |
PRIDEi | Q13601 |
ProteomicsDBi | 59591 [Q13601-1] 59592 [Q13601-2] |
2D gel databases
SWISS-2DPAGEi | Q13601 |
PTM databases
iPTMneti | Q13601 |
PhosphoSitePlusi | Q13601 |
SwissPalmi | Q13601 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111615, Expressed in calcaneal tendon and 244 other tissues |
Genevisiblei | Q13601, HS |
Organism-specific databases
HPAi | ENSG00000111615, Low tissue specificity |
Interactioni
Subunit structurei
Component of the ribosomal small subunit (SSU) processome (By similarity). Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR.
By similarity1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 116284, 115 interactors |
IntActi | Q13601, 44 interactors |
MINTi | Q13601 |
STRINGi | 9606.ENSP00000229214 |
Miscellaneous databases
RNActi | Q13601, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 154 – 206 | KHAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 247 – 381 | Lys-richAdd BLAST | 135 |
Sequence similaritiesi
Belongs to the KRR1 family.Curated
Phylogenomic databases
eggNOGi | KOG2874, Eukaryota |
GeneTreei | ENSGT00390000018775 |
HOGENOMi | CLU_040185_0_0_1 |
InParanoidi | Q13601 |
OMAi | VHKKEKF |
OrthoDBi | 944899at2759 |
PhylomeDBi | Q13601 |
TreeFami | TF105745 |
Family and domain databases
Gene3Di | 3.30.1370.10, 2 hits |
InterProi | View protein in InterPro IPR041174, KH_8 IPR004087, KH_dom IPR036612, KH_dom_type_1_sf IPR024166, rRNA_assembly_KRR1 |
PANTHERi | PTHR12581, PTHR12581, 1 hit |
Pfami | View protein in Pfam PF17903, KH_8, 1 hit |
PIRSFi | PIRSF006515, KRR1, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 1 hit |
SUPFAMi | SSF54791, SSF54791, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q13601-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASPSLERPE KGAGKSEFRN QKPKPENQDE SELLTVPDGW KEPAFSKEDN
60 70 80 90 100
PRGLLEESSF ATLFPKYREA YLKECWPLVQ KALNEHHVNA TLDLIEGSMT
110 120 130 140 150
VCTTKKTFDP YIIIRARDLI KLLARSVSFE QAVRILQDDV ACDIIKIGSL
160 170 180 190 200
VRNKERFVKR RQRLIGPKGS TLKALELLTN CYIMVQGNTV SAIGPFSGLK
210 220 230 240 250
EVRKVVLDTM KNIHPIYNIK SLMIKRELAK DSELRSQSWE RFLPQFKHKN
260 270 280 290 300
VNKRKEPKKK TVKKEYTPFP PPQPESQIDK ELASGEYFLK ANQKKRQKME
310 320 330 340 350
AIKAKQAEAI SKRQEERNKA FIPPKEKPIV KPKEASTETK IDVASIKEKV
360 370 380
KKAKNKKLGA LTAEEIALKM EADEKKKKKK K
Sequence cautioni
The sequence AAB00557 differs from that shown. Reason: Frameshift.Curated
The sequence AAH05225 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | A → V in ABJ97679 (Ref. 1) Curated | 1 | |
Sequence conflicti | 57 | E → K in BAG36436 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 69 | E → G in AAH16778 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 161 | R → G in ABJ97679 (Ref. 1) Curated | 1 | |
Sequence conflicti | 165 | I → V in ABJ97679 (Ref. 1) Curated | 1 | |
Sequence conflicti | 206 | V → A in AAH26107 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 275 | E → G in AAH33887 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 339 | T → A in ABJ97679 (Ref. 1) Curated | 1 | |
Sequence conflicti | 339 | T → A in AAH33887 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 353 | A → G in AAH05225 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049680 | 134 | R → Q. Corresponds to variant dbSNP:rs11540407Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042223 | 221 – 277 | Missing in isoform 2. 1 PublicationAdd BLAST | 57 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF010919 mRNA Translation: ABJ97679.1 AK313687 mRNA Translation: BAG36436.1 AC022507 Genomic DNA No translation available. AC121761 Genomic DNA No translation available. BC005225 mRNA Translation: AAH05225.1 Sequence problems. BC016778 mRNA Translation: AAH16778.1 BC026107 mRNA Translation: AAH26107.1 BC033887 mRNA Translation: AAH33887.1 U55766 mRNA Translation: AAB00557.1 Frameshift. |
CCDSi | CCDS9012.1 [Q13601-1] |
PIRi | G02629 |
RefSeqi | NP_008974.5, NM_007043.6 [Q13601-1] |
Genome annotation databases
Ensembli | ENST00000229214; ENSP00000229214; ENSG00000111615 [Q13601-1] ENST00000438169; ENSP00000411740; ENSG00000111615 [Q13601-2] |
GeneIDi | 11103 |
KEGGi | hsa:11103 |
UCSCi | uc001sxt.4, human [Q13601-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF010919 mRNA Translation: ABJ97679.1 AK313687 mRNA Translation: BAG36436.1 AC022507 Genomic DNA No translation available. AC121761 Genomic DNA No translation available. BC005225 mRNA Translation: AAH05225.1 Sequence problems. BC016778 mRNA Translation: AAH16778.1 BC026107 mRNA Translation: AAH26107.1 BC033887 mRNA Translation: AAH33887.1 U55766 mRNA Translation: AAB00557.1 Frameshift. |
CCDSi | CCDS9012.1 [Q13601-1] |
PIRi | G02629 |
RefSeqi | NP_008974.5, NM_007043.6 [Q13601-1] |
3D structure databases
SMRi | Q13601 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116284, 115 interactors |
IntActi | Q13601, 44 interactors |
MINTi | Q13601 |
STRINGi | 9606.ENSP00000229214 |
PTM databases
iPTMneti | Q13601 |
PhosphoSitePlusi | Q13601 |
SwissPalmi | Q13601 |
Polymorphism and mutation databases
BioMutai | KRR1 |
DMDMi | 50400303 |
2D gel databases
SWISS-2DPAGEi | Q13601 |
Proteomic databases
EPDi | Q13601 |
jPOSTi | Q13601 |
MassIVEi | Q13601 |
MaxQBi | Q13601 |
PaxDbi | Q13601 |
PeptideAtlasi | Q13601 |
PRIDEi | Q13601 |
ProteomicsDBi | 59591 [Q13601-1] 59592 [Q13601-2] |
Protocols and materials databases
Antibodypediai | 29617, 172 antibodies |
DNASUi | 11103 |
Genome annotation databases
Ensembli | ENST00000229214; ENSP00000229214; ENSG00000111615 [Q13601-1] ENST00000438169; ENSP00000411740; ENSG00000111615 [Q13601-2] |
GeneIDi | 11103 |
KEGGi | hsa:11103 |
UCSCi | uc001sxt.4, human [Q13601-1] |
Organism-specific databases
CTDi | 11103 |
DisGeNETi | 11103 |
EuPathDBi | HostDB:ENSG00000111615.12 |
GeneCardsi | KRR1 |
HGNCi | HGNC:5176, KRR1 |
HPAi | ENSG00000111615, Low tissue specificity |
MIMi | 612817, gene |
neXtProti | NX_Q13601 |
OpenTargetsi | ENSG00000111615 |
PharmGKBi | PA29450 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2874, Eukaryota |
GeneTreei | ENSGT00390000018775 |
HOGENOMi | CLU_040185_0_0_1 |
InParanoidi | Q13601 |
OMAi | VHKKEKF |
OrthoDBi | 944899at2759 |
PhylomeDBi | Q13601 |
TreeFami | TF105745 |
Enzyme and pathway databases
PathwayCommonsi | Q13601 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 11103, 685 hits in 848 CRISPR screens |
ChiTaRSi | KRR1, human |
GeneWikii | KRR1 |
GenomeRNAii | 11103 |
Pharosi | Q13601, Tbio |
PROi | PR:Q13601 |
RNActi | Q13601, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111615, Expressed in calcaneal tendon and 244 other tissues |
Genevisiblei | Q13601, HS |
Family and domain databases
Gene3Di | 3.30.1370.10, 2 hits |
InterProi | View protein in InterPro IPR041174, KH_8 IPR004087, KH_dom IPR036612, KH_dom_type_1_sf IPR024166, rRNA_assembly_KRR1 |
PANTHERi | PTHR12581, PTHR12581, 1 hit |
Pfami | View protein in Pfam PF17903, KH_8, 1 hit |
PIRSFi | PIRSF006515, KRR1, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 1 hit |
SUPFAMi | SSF54791, SSF54791, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KRR1_HUMAN | |
Accessioni | Q13601Primary (citable) accession number: Q13601 Secondary accession number(s): A0FIK6 Q96AT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations