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UniProtKB - Q13601 (KRR1_HUMAN)

Entry version 169 (12 Aug 2020)
Sequence version 4 (23 Jan 2007)
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Protein

KRR1 small subunit processome component homolog

Gene

KRR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13601

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6790901, rRNA modification in the nucleus and cytosol
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
KRR1 small subunit processome component homolog
Alternative name(s):
HIV-1 Rev-binding protein 2
KRR-R motif-containing protein 1
Rev-interacting protein 1
Short name:
Rip-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRR1
Synonyms:HRB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000111615.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:5176, KRR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612817, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13601

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		11103

Open Targets

More...OpenTargetsi		ENSG00000111615

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29450

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13601, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KRR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		50400303

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000501142 – 381KRR1 small subunit processome component homologAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei3PhosphoserineCombined sources1
Modified residuei5PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki340Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki369Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13601

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13601

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13601

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13601

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13601

PeptideAtlas

More...PeptideAtlasi		Q13601

PRoteomics IDEntifications database

More...PRIDEi		Q13601

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59591 [Q13601-1]
59592 [Q13601-2]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		Q13601

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13601

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13601

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q13601

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111615, Expressed in calcaneal tendon and 244 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13601, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111615, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ribosomal small subunit (SSU) processome (By similarity). Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116284, 113 interactors

Protein interaction database and analysis system

More...IntActi		Q13601, 44 interactors

Molecular INTeraction database

More...MINTi		Q13601

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000229214

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13601, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13601

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini154 – 206KHAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi247 – 381Lys-richAdd BLAST135

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRR1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2874, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018775

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_040185_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13601

KEGG Orthology (KO)

More...KOi		K06961

Identification of Orthologs from Complete Genome Data

More...OMAi		VHKKEKF

Database of Orthologous Groups

More...OrthoDBi		944899at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13601

TreeFam database of animal gene trees

More...TreeFami		TF105745

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1370.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041174, KH_8
IPR004087, KH_dom
IPR036612, KH_dom_type_1_sf
IPR024166, rRNA_assembly_KRR1

The PANTHER Classification System

More...PANTHERi		PTHR12581, PTHR12581, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17903, KH_8, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF006515, KRR1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00322, KH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54791, SSF54791, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13601-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPSLERPE KGAGKSEFRN QKPKPENQDE SELLTVPDGW KEPAFSKEDN 
        60         70         80         90        100
PRGLLEESSF ATLFPKYREA YLKECWPLVQ KALNEHHVNA TLDLIEGSMT 
       110        120        130        140        150
VCTTKKTFDP YIIIRARDLI KLLARSVSFE QAVRILQDDV ACDIIKIGSL 
       160        170        180        190        200
VRNKERFVKR RQRLIGPKGS TLKALELLTN CYIMVQGNTV SAIGPFSGLK 
       210        220        230        240        250
EVRKVVLDTM KNIHPIYNIK SLMIKRELAK DSELRSQSWE RFLPQFKHKN 
       260        270        280        290        300
VNKRKEPKKK TVKKEYTPFP PPQPESQIDK ELASGEYFLK ANQKKRQKME 
       310        320        330        340        350
AIKAKQAEAI SKRQEERNKA FIPPKEKPIV KPKEASTETK IDVASIKEKV 
       360        370        380 
KKAKNKKLGA LTAEEIALKM EADEKKKKKK K
Length:381
Mass (Da):43,665
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F242FCC36BF079B
GO
Isoform 2 (identifier: Q13601-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-277: Missing.

Show »
Length:324
Mass (Da):36,788
Checksum:iFE9A271F5ABBBB6F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB00557 differs from that shown. Reason: Frameshift.Curated
The sequence AAH05225 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13A → V in ABJ97679 (Ref. 1) Curated1
Sequence conflicti57E → K in BAG36436 (PubMed:14702039).Curated1
Sequence conflicti69E → G in AAH16778 (PubMed:15489334).Curated1
Sequence conflicti161R → G in ABJ97679 (Ref. 1) Curated1
Sequence conflicti165I → V in ABJ97679 (Ref. 1) Curated1
Sequence conflicti206V → A in AAH26107 (PubMed:15489334).Curated1
Sequence conflicti275E → G in AAH33887 (PubMed:15489334).Curated1
Sequence conflicti339T → A in ABJ97679 (Ref. 1) Curated1
Sequence conflicti339T → A in AAH33887 (PubMed:15489334).Curated1
Sequence conflicti353A → G in AAH05225 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049680134R → Q. Corresponds to variant dbSNP:rs11540407Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042223221 – 277Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EF010919 mRNA Translation: ABJ97679.1
AK313687 mRNA Translation: BAG36436.1
AC022507 Genomic DNA No translation available.
AC121761 Genomic DNA No translation available.
BC005225 mRNA Translation: AAH05225.1 Sequence problems.
BC016778 mRNA Translation: AAH16778.1
BC026107 mRNA Translation: AAH26107.1
BC033887 mRNA Translation: AAH33887.1
U55766 mRNA Translation: AAB00557.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9012.1 [Q13601-1]

Protein sequence database of the Protein Information Resource

More...PIRi		G02629

NCBI Reference Sequences

More...RefSeqi		NP_008974.5, NM_007043.6 [Q13601-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000229214; ENSP00000229214; ENSG00000111615 [Q13601-1]
ENST00000438169; ENSP00000411740; ENSG00000111615 [Q13601-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11103

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11103

UCSC genome browser

More...UCSCi		uc001sxt.4, human [Q13601-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF010919 mRNA Translation: ABJ97679.1
AK313687 mRNA Translation: BAG36436.1
AC022507 Genomic DNA No translation available.
AC121761 Genomic DNA No translation available.
BC005225 mRNA Translation: AAH05225.1 Sequence problems.
BC016778 mRNA Translation: AAH16778.1
BC026107 mRNA Translation: AAH26107.1
BC033887 mRNA Translation: AAH33887.1
U55766 mRNA Translation: AAB00557.1 Frameshift.
CCDSiCCDS9012.1 [Q13601-1]
PIRiG02629
RefSeqiNP_008974.5, NM_007043.6 [Q13601-1]

3D structure databases

SMRiQ13601
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116284, 113 interactors
IntActiQ13601, 44 interactors
MINTiQ13601
STRINGi9606.ENSP00000229214

PTM databases

iPTMnetiQ13601
PhosphoSitePlusiQ13601
SwissPalmiQ13601

Polymorphism and mutation databases

BioMutaiKRR1
DMDMi50400303

2D gel databases

SWISS-2DPAGEiQ13601

Proteomic databases

EPDiQ13601
jPOSTiQ13601
MassIVEiQ13601
MaxQBiQ13601
PaxDbiQ13601
PeptideAtlasiQ13601
PRIDEiQ13601
ProteomicsDBi59591 [Q13601-1]
59592 [Q13601-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29617, 172 antibodies

The DNASU plasmid repository

More...DNASUi		11103

Genome annotation databases

EnsembliENST00000229214; ENSP00000229214; ENSG00000111615 [Q13601-1]
ENST00000438169; ENSP00000411740; ENSG00000111615 [Q13601-2]
GeneIDi11103
KEGGihsa:11103
UCSCiuc001sxt.4, human [Q13601-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11103
DisGeNETi11103
EuPathDBiHostDB:ENSG00000111615.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		KRR1
HGNCiHGNC:5176, KRR1
HPAiENSG00000111615, Low tissue specificity
MIMi612817, gene
neXtProtiNX_Q13601
OpenTargetsiENSG00000111615
PharmGKBiPA29450

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2874, Eukaryota
GeneTreeiENSGT00390000018775
HOGENOMiCLU_040185_0_0_1
InParanoidiQ13601
KOiK06961
OMAiVHKKEKF
OrthoDBi944899at2759
PhylomeDBiQ13601
TreeFamiTF105745

Enzyme and pathway databases

PathwayCommonsiQ13601
ReactomeiR-HSA-6790901, rRNA modification in the nucleus and cytosol
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11103, 685 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KRR1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KRR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11103
PharosiQ13601, Tbio

Protein Ontology

More...PROi		PR:Q13601
RNActiQ13601, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111615, Expressed in calcaneal tendon and 244 other tissues
GenevisibleiQ13601, HS

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR041174, KH_8
IPR004087, KH_dom
IPR036612, KH_dom_type_1_sf
IPR024166, rRNA_assembly_KRR1
PANTHERiPTHR12581, PTHR12581, 1 hit
PfamiView protein in Pfam
PF17903, KH_8, 1 hit
PIRSFiPIRSF006515, KRR1, 1 hit
SMARTiView protein in SMART
SM00322, KH, 1 hit
SUPFAMiSSF54791, SSF54791, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13601
Secondary accession number(s): A0FIK6
, A0JLP0, B2R989, E7EUQ0, Q8NEA8, Q8TC37, Q96AT5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: August 12, 2020
This is version 169 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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