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Protein

Transformer-2 protein homolog alpha

Gene

TRA2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.1 Publication

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Transformer-2 protein homolog alpha
Short name:
TRA-2 alpha
Short name:
TRA2-alpha
Alternative name(s):
Transformer-2 protein homolog A
Gene namesi
Name:TRA2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164548.10
HGNCiHGNC:16645 TRA2A
MIMi602718 gene
neXtProtiNX_Q13595

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29896
OpenTargetsiENSG00000164548
PharmGKBiPA164726707

Polymorphism and mutation databases

DMDMi4033480

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000819812 – 282Transformer-2 protein homolog alphaAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei24PhosphothreonineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei88PhosphothreonineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei202PhosphothreonineCombined sources1
Modified residuei204PhosphothreonineCombined sources1
Modified residuei232Omega-N-methylarginineBy similarity1
Modified residuei236PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in the RS domains.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13595
PaxDbiQ13595
PeptideAtlasiQ13595
PRIDEiQ13595
ProteomicsDBi59587
59588 [Q13595-2]

PTM databases

iPTMnetiQ13595
PhosphoSitePlusiQ13595
SwissPalmiQ13595

Expressioni

Gene expression databases

BgeeiENSG00000164548
ExpressionAtlasiQ13595 baseline and differential
GenevisibleiQ13595 HS

Organism-specific databases

HPAiHPA054018

Interactioni

Subunit structurei

Binds to A3 enhancer proteins SRp75, SRp55, SRp40 and SRp30.

Protein-protein interaction databases

BioGridi118948, 219 interactors
IntActiQ13595, 34 interactors
MINTiQ13595
STRINGi9606.ENSP00000297071

Structurei

3D structure databases

ProteinModelPortaliQ13595
SMRiQ13595
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 197RRMPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 225LinkerAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 112Arg/Ser-rich (RS1 domain)Add BLAST83
Compositional biasi226 – 282Arg/Ser-rich (RS2 domain)Add BLAST57

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Phylogenomic databases

eggNOGiENOG410IQWZ Eukaryota
ENOG4111HSX LUCA
GeneTreeiENSGT00710000106295
HOGENOMiHOG000276232
HOVERGENiHBG102125
InParanoidiQ13595
KOiK12897
OMAiDRYEEYD
OrthoDBiEOG091G0Y02
PhylomeDBiQ13595
TreeFamiTF106265

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q13595-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDVEENNFE GRESRSQSKS PTGTPARVKS ESRSGSRSPS RVSKHSESHS
60 70 80 90 100
RSRSKSRSRS RRHSHRRYTR SRSHSHSHRR RSRSRSYTPE YRRRRSRSHS
110 120 130 140 150
PMSNRRRHTG SRANPDPNTC LGVFGLSLYT TERDLREVFS RYGPLSGVNV
160 170 180 190 200
VYDQRTGRSR GFAFVYFERI DDSKEAMERA NGMELDGRRI RVDYSITKRA
210 220 230 240 250
HTPTPGIYMG RPTHSGGGGG GGGGGGGGGG GRRRDSYYDR GYDRGYDRYE
260 270 280
DYDYRYRRRS PSPYYSRYRS RSRSRSYSPR RY
Length:282
Mass (Da):32,689
Last modified:November 1, 1996 - v1
Checksum:iEDB5ABE7BEA023FD
GO
Isoform Short (identifier: Q13595-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     214-214: H → Q
     215-282: Missing.

Show »
Length:113
Mass (Da):12,952
Checksum:iD7E4DDF02E52CEA0
GO
Isoform 3 (identifier: Q13595-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):20,746
Checksum:i440524DD6FEC3910
GO
Isoform 4 (identifier: Q13595-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     257-257: Missing.

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):20,590
Checksum:i792DF54BE964E333
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0058931 – 101Missing in isoform Short, isoform 3 and isoform 4. 2 PublicationsAdd BLAST101
Alternative sequenceiVSP_005894214H → Q in isoform Short. 1 Publication1
Alternative sequenceiVSP_005895215 – 282Missing in isoform Short. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_057405257Missing in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53209 mRNA Translation: AAC50658.1
AK298815 mRNA Translation: BAG60948.1
AK300565 mRNA Translation: BAG62271.1
AK300741 mRNA Translation: BAG62410.1
AC023105 Genomic DNA No translation available.
BC017094 mRNA Translation: AAH17094.1
CCDSiCCDS5383.1 [Q13595-1]
CCDS64609.1 [Q13595-3]
CCDS75569.1 [Q13595-4]
RefSeqiNP_001269686.1, NM_001282757.1 [Q13595-3]
NP_001269687.1, NM_001282758.1 [Q13595-3]
NP_001269688.1, NM_001282759.1 [Q13595-4]
NP_037425.1, NM_013293.4 [Q13595-1]
XP_005249782.1, XM_005249725.1 [Q13595-3]
XP_016867578.1, XM_017012089.1 [Q13595-3]
XP_016867579.1, XM_017012090.1 [Q13595-3]
UniGeneiHs.445652

Genome annotation databases

EnsembliENST00000297071; ENSP00000297071; ENSG00000164548 [Q13595-1]
ENST00000392502; ENSP00000376290; ENSG00000164548 [Q13595-4]
ENST00000538367; ENSP00000441116; ENSG00000164548 [Q13595-3]
ENST00000621813; ENSP00000480822; ENSG00000164548 [Q13595-3]
GeneIDi29896
KEGGihsa:29896
UCSCiuc011jzb.4 human
uc011jzc.5 human [Q13595-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRA2A_HUMAN
AccessioniPrimary (citable) accession number: Q13595
Secondary accession number(s): B4DQI6, B4DUA9, E9PD75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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