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Protein

Semaphorin-5A

Gene

SEMA5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.By similarity4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-416700 Other semaphorin interactions
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-5A
Alternative name(s):
Semaphorin-F
Short name:
Sema F
Gene namesi
Name:SEMA5A
Synonyms:SEMAF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000112902.11
HGNCiHGNC:10736 SEMA5A
MIMi609297 gene
neXtProtiNX_Q13591

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 968ExtracellularSequence analysisAdd BLAST946
Transmembranei969 – 989HelicalSequence analysisAdd BLAST21
Topological domaini990 – 1074CytoplasmicSequence analysisAdd BLAST85

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9037
MalaCardsiSEMA5A
OpenTargetsiENSG00000112902
Orphaneti281 Monosomy 5p
PharmGKBiPA35658

Polymorphism and mutation databases

BioMutaiSEMA5A
DMDMi109939725

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003233523 – 1074Semaphorin-5AAdd BLAST1052

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi104 ↔ 114By similarity
Disulfide bondi131 ↔ 140By similarity
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi254 ↔ 357By similarity
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi278 ↔ 320By similarity
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi487 ↔ 504By similarity
Disulfide bondi496 ↔ 513By similarity
Glycosylationi536N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi591N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi607 ↔ 644By similarity
Disulfide bondi611 ↔ 650By similarity
Disulfide bondi622 ↔ 634By similarity
Disulfide bondi665 ↔ 696By similarity
Disulfide bondi669 ↔ 701By similarity
Disulfide bondi680 ↔ 686By similarity
Glycosylationi717N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi796 ↔ 833By similarity
Disulfide bondi800 ↔ 838By similarity
Disulfide bondi811 ↔ 823By similarity
Disulfide bondi853 ↔ 890By similarity
Disulfide bondi857 ↔ 895By similarity
Disulfide bondi868 ↔ 880By similarity
Glycosylationi933N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ13591
PaxDbiQ13591
PeptideAtlasiQ13591
PRIDEiQ13591
ProteomicsDBi59586

PTM databases

iPTMnetiQ13591
PhosphoSitePlusiQ13591

Expressioni

Gene expression databases

BgeeiENSG00000112902
CleanExiHS_SEMA5A
ExpressionAtlasiQ13591 baseline and differential
GenevisibleiQ13591 HS

Organism-specific databases

HPAiHPA004632

Interactioni

Subunit structurei

Binds PLXNB3.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ13591, 1 interactor
STRINGi9606.ENSP00000371936

Structurei

3D structure databases

ProteinModelPortaliQ13591
SMRiQ13591
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 484SemaPROSITE-ProRule annotationAdd BLAST450
Domaini540 – 593TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini595 – 651TSP type-1 2PROSITE-ProRule annotationAdd BLAST57
Domaini653 – 702TSP type-1 3PROSITE-ProRule annotationAdd BLAST50
Domaini707 – 765TSP type-1 4PROSITE-ProRule annotationAdd BLAST59
Domaini784 – 839TSP type-1 5PROSITE-ProRule annotationAdd BLAST56
Domaini841 – 896TSP type-1 6PROSITE-ProRule annotationAdd BLAST56
Domaini897 – 944TSP type-1 7PROSITE-ProRule annotationAdd BLAST48

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000119134
HOGENOMiHOG000047106
HOVERGENiHBG062356
InParanoidiQ13591
KOiK06841
OMAiYSNAYFT
OrthoDBiEOG091G01T5
PhylomeDBiQ13591
TreeFamiTF329951

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.20.100.10, 6 hits
InterProiView protein in InterPro
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 3 hits
PfamiView protein in Pfam
PF01403 Sema, 1 hit
PF00090 TSP_1, 5 hits
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SM00209 TSP1, 6 hits
SUPFAMiSSF101912 SSF101912, 1 hit
SSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
PS50092 TSP1, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGTCVIAWL FSSLGLWRLA HPEAQGTTQC QRTEHPVISY KEIGPWLREF
60 70 80 90 100
RAKNAVDFSQ LTFDPGQKEL VVGARNYLFR LQLEDLSLIQ AVEWECDEAT
110 120 130 140 150
KKACYSKGKS KEECQNYIRV LLVGGDRLFT CGTNAFTPVC TNRSLSNLTE
160 170 180 190 200
IHDQISGMAR CPYSPQHNST ALLTAGGELY AATAMDFPGR DPAIYRSLGI
210 220 230 240 250
LPPLRTAQYN SKWLNEPNFV SSYDIGNFTY FFFRENAVEH DCGKTVFSRA
260 270 280 290 300
ARVCKNDIGG RFLLEDTWTT FMKARLNCSR PGEVPFYYNE LQSTFFLPEL
310 320 330 340 350
DLIYGIFTTN VNSIAASAVC VFNLSAIAQA FSGPFKYQEN SRSAWLPYPN
360 370 380 390 400
PNPHFQCGTV DQGLYVNLTE RNLQDAQKFI LMHEVVQPVT TVPSFMEDNS
410 420 430 440 450
RFSHVAVDVV QGREALVHII YLATDYGTIK KVRVPLNQTS SSCLLEEIEL
460 470 480 490 500
FPERRREPIR SLQILHSQSV LFVGLREHVV KIPLKRCQFY RTRSTCIGAQ
510 520 530 540 550
DPYCGWDVVM KKCTSLEESL SMTQWEQSIS ACPTRNLTVD GHFGVWSPWT
560 570 580 590 600
PCTHTDGSAV GSCLCRTRSC DSPAPQCGGW QCEGPGMEIA NCSRNGGWTP
610 620 630 640 650
WTSWSPCSTT CGIGFQVRQR SCSNPTPRHG GRVCVGQNRE ERYCNEHLLC
660 670 680 690 700
PPHMFWTGWG PWERCTAQCG GGIQARRRIC ENGPDCAGCN VEYQSCNTNP
710 720 730 740 750
CPELKKTTPW TPWTPVNISD NGGHYEQRFR YTCKARLADP NLLEVGRQRI
760 770 780 790 800
EMRYCSSDGT SGCSTDGLSG DFLRAGRYSA HTVNGAWSAW TSWSQCSRDC
810 820 830 840 850
SRGIRNRKRV CNNPEPKYGG MPCLGPSLEY QECNILPCPV DGVWSCWSPW
860 870 880 890 900
TKCSATCGGG HYMRTRSCSN PAPAYGGDIC LGLHTEEALC NTQPCPESWS
910 920 930 940 950
EWSDWSECEA SGVQVRARQC ILLFPMGSQC SGNTTESRPC VFDSNFIPEV
960 970 980 990 1000
SVARSSSVEE KRCGEFNMFH MIAVGLSSSI LGCLLTLLVY TYCQRYQQQS
1010 1020 1030 1040 1050
HDATVIHPVS PAPLNTSITN HINKLDKYDS VEAIKAFNKN NLILEERNKY
1060 1070
FNPHLTGKTY SNAYFTDLNN YDEY
Length:1,074
Mass (Da):120,615
Last modified:May 30, 2006 - v3
Checksum:iAE073413AC974CCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56V → A in AAC09473 (PubMed:9464278).Curated1
Sequence conflicti149T → A in AAC09473 (PubMed:9464278).Curated1
Sequence conflicti382M → V in AAC09473 (PubMed:9464278).Curated1
Sequence conflicti494S → R in AAC14668 (PubMed:15372022).Curated1
Sequence conflicti723G → D in AAC09473 (PubMed:9464278).Curated1
Sequence conflicti835I → T in AAC09473 (PubMed:9464278).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078706196 – 1074Missing Probable disease-associated mutation found in a patient with autism spectrum disorder. 1 PublicationAdd BLAST879
Natural variantiVAR_030294246V → L. Corresponds to variant dbSNP:rs1806079Ensembl.1
Natural variantiVAR_030295792S → L. Corresponds to variant dbSNP:rs2290734Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52840 mRNA Translation: AAC09473.1
AC004615 Genomic DNA Translation: AAC14668.1
AC022446 Genomic DNA No translation available.
AC027336 Genomic DNA No translation available.
AC091906 Genomic DNA No translation available.
CH471102 Genomic DNA Translation: EAX08078.1
CH471102 Genomic DNA Translation: EAX08079.1
BC115696 mRNA Translation: AAI15697.1
CCDSiCCDS3875.1
PIRiJC5928
RefSeqiNP_003957.2, NM_003966.2
XP_006714569.1, XM_006714506.2
XP_006714570.1, XM_006714507.3
XP_011512457.1, XM_011514155.2
XP_011512458.1, XM_011514156.1
XP_011512459.1, XM_011514157.1
XP_011512460.1, XM_011514158.1
UniGeneiHs.27621

Genome annotation databases

EnsembliENST00000382496; ENSP00000371936; ENSG00000112902
GeneIDi9037
KEGGihsa:9037

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSEM5A_HUMAN
AccessioniPrimary (citable) accession number: Q13591
Secondary accession number(s): D3DTC6, O60408, Q1RLL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2006
Last modified: June 20, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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