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Protein

Stromal interaction molecule 1

Gene

STIM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928). Acts as Ca2+ sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca2+ depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679).17 Publications

Miscellaneous

Transfection of STIM1 into cells derived from a rhabdoid tumor and from a rhabdomyosarcoma that do not express detectable levels of STIM1 can induce cell death, suggesting a possible role in the control of rhabdomyosarcomas and rhabdoid tumors.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi76 – 87Add BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-5578775 Ion homeostasis
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SIGNOR Signaling Network Open Resource

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SIGNORi
Q13586

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.52.1.1 the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stromal interaction molecule 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STIM1
Synonyms:GOK1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000167323.9

Human Gene Nomenclature Database

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HGNCi
HGNC:11386 STIM1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605921 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13586

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 213ExtracellularSequence analysisAdd BLAST191
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 685CytoplasmicSequence analysisAdd BLAST451

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Microtubule, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 10 (IMD10)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn immune disorder characterized by recurrent infections, impaired activation and proliferative response of T-cells, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.
See also OMIM:612783
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069896429R → C in IMD10. 1 PublicationCorresponds to variant dbSNP:rs397514671EnsemblClinVar.1
Myopathy, tubular aggregate, 1 (TAM1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital myopathy characterized by regular arrays of membrane tubules on muscle biopsies without additional histopathological hallmarks. Tubular aggregates in muscle are structures of variable appearance consisting of an outer tubule containing either one or more microtubule-like structures or amorphous material. They may occur in a variety of circumstances, including inherited myopathies, alcohol- and drug-induced myopathies, exercise-induced cramps or muscle weakness.
See also OMIM:160565
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06989272H → Q in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 PublicationCorresponds to variant dbSNP:rs397515436EnsemblClinVar.1
Natural variantiVAR_07561980N → T in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 PublicationCorresponds to variant dbSNP:rs748277951EnsemblClinVar.1
Natural variantiVAR_07562081G → D in TAM1; increases store-operated Ca(2+) influx. 1 Publication1
Natural variantiVAR_06989384D → G in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 PublicationCorresponds to variant dbSNP:rs397514675EnsemblClinVar.1
Natural variantiVAR_07562196L → V in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 Publication1
Natural variantiVAR_075622108F → I in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 Publication1
Natural variantiVAR_075623108F → L in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 Publication1
Natural variantiVAR_069894109H → N in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 2 PublicationsCorresponds to variant dbSNP:rs397514676EnsemblClinVar.1
Natural variantiVAR_069895109H → R in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 2 PublicationsCorresponds to variant dbSNP:rs397514677EnsemblClinVar.1
Natural variantiVAR_074037115I → F in STRMK and TAM1. 2 PublicationsCorresponds to variant dbSNP:rs527236030EnsemblClinVar.1
Stormorken syndrome (STRMK)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal dominant disease characterized by mild bleeding tendency, thrombocytopathy, thrombocytopenia, mild anemia, asplenia, tubular aggregate myopathy, miosis, headache, and ichthyosis.
See also OMIM:185070
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074037115I → F in STRMK and TAM1. 2 PublicationsCorresponds to variant dbSNP:rs527236030EnsemblClinVar.1
Natural variantiVAR_071476304R → W in STRMK; autosomal dominant; promotes constitutive activation of the Ca(2+) release-activated Ca(2+) (CRAC) channel. 3 PublicationsCorresponds to variant dbSNP:rs483352867EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi76D → A or N: Increases Ca(2+) influx even when Ca(2+) stores are not depleted. Promotes constitutive activation of the Ca2+ release-activated Ca2+ (CRAC) channel. 4 Publications1
Mutagenesisi78D → N: Increases Ca(2+) influx even when Ca(2+) stores are not depleted. 1 Publication1
Mutagenesisi87E → A or Q: Increases Ca(2+) influx through activation of CRAC channels, even when Ca(2+) stores are not depleted. 3 Publications1
Mutagenesisi108F → D: Constitutive localization in punctae at the cell membrane and constitutive activation of CRAC channels; when associated with D-110. 1 Publication1
Mutagenesisi110G → D: Constitutive localization in punctae at the cell membrane and constitutive activation of CRAC channels; when associated with D-108. 1 Publication1
Mutagenesisi195L → R: Constitutive localization in punctae at the cell membrane and constitutive activation of CRAC channels. 1 Publication1
Mutagenesisi258L → G: Promotes constitutive activation of the Ca2+ release-activated Ca2+ (CRAC) channel. 1 Publication1
Mutagenesisi318 – 322EEELE → QQQLQ: Constitutive activation of CRAC channels. 1 Publication5
Mutagenesisi324V → P: Reduces activation of CRAC channels. 1 Publication1
Mutagenesisi347L → R: Abolishes colocalization with ORAI1 and activation of CRAC channels. 1 Publication1
Mutagenesisi351L → R: Abolishes colocalization with ORAI1 and activation of CRAC channels. 1 Publication1
Mutagenesisi361 – 362YY → KK: Abolishes activation of CRAC channels. 1 Publication2
Mutagenesisi380A → R: Constitutive activation of CRAC channels. 1 Publication1
Mutagenesisi382 – 386KIKKK → EIEEE: Abolishes activation of CRAC channels. 1 Publication5
Mutagenesisi383I → R: Abolishes activation of CRAC channels. 1
Mutagenesisi644 – 645IP → NN: Loss of interaction with MAPRE1 and association with the growing microtubule plus ends. 1 Publication2

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
6786

MalaCards human disease database

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MalaCardsi
STIM1
MIMi160565 phenotype
185070 phenotype
612783 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000167323

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
317430 Combined immunodeficiency due to STIM1 deficiency
3204 Stormorken-Sjaastad-Langslet syndrome
2593 Tubular aggregate myopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36195

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3832644

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
STIM1

Domain mapping of disease mutations (DMDM)

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DMDMi
209572721

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003332623 – 685Stromal interaction molecule 1Add BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi131N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi171N-linked (GlcNAc...) asparagine4 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei257PhosphoserineCombined sources1
Modified residuei504PhosphothreonineBy similarity1
Modified residuei512PhosphoserineCombined sources1
Modified residuei517PhosphothreonineCombined sources1
Modified residuei519PhosphoserineCombined sources1
Modified residuei521PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei524PhosphoserineBy similarity1
Modified residuei567PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei618PhosphoserineCombined sources1
Modified residuei621PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Modified residuei665PhosphothreonineCombined sources1
Modified residuei668PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylation is required for cell surface expression.5 Publications
Phosphorylated predominantly on Ser residues.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13586

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13586

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13586

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13586

PeptideAtlas

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PeptideAtlasi
Q13586

PRoteomics IDEntifications database

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PRIDEi
Q13586

ProteomicsDB human proteome resource

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ProteomicsDBi
59584

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1771

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13586

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13586

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed in various human primary cells and tumor cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000167323 Expressed in 192 organ(s), highest expression level in gastrocnemius

CleanEx database of gene expression profiles

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CleanExi
HS_STIM1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13586 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13586 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB037128
CAB037288
HPA011088
HPA012123

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer in the presence of Ca2+; it oligomerizes in absence of Ca2+ (PubMed:18854159). Forms homooligomers and heterooligomers with STIM2 (PubMed:11463338, PubMed:11983428, PubMed:18854159, PubMed:22451904, PubMed:24351972, PubMed:24069340). Interacts (via the transmembrane region and the SOAR/CAD domain) with SPPL3; the interaction promotes the binding of STIM1 to ORAI1 (PubMed:25384971). Interacts with ORAI1 (PubMed:17905723, PubMed:19249086, PubMed:27185316, PubMed:24351972, PubMed:28219928). Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends (PubMed:19632184). Interacts with CRACR2A/EFCAB4B; the interaction is direct and takes place in absence of Ca2+ (PubMed:20418871). Forms a complex with CRACR2A/EFCAB4B and ORAI1 at low concentration of Ca2+, the complex dissociates at elevated Ca2+ concentrations (PubMed:20418871). Interacts with SARAF, promoting a slow inactivation of STIM1-dependent SOCE activity, possibly by facilitating the deoligomerization of STIM1 (PubMed:22464749). Interacts with ASPH (isoform 8) (PubMed:22586105). Interacts with SLC35G1; intracellular Ca2+-dependent. May interact with ATP1A1, ATP2A2, ATP2B1, ATP2B4, KPNB1 and XPO1; through SLC35G1 (PubMed:22084111). Interacts with TMEM203 (PubMed:25996873). Interacts with STIMATE, promoting STIM1 conformational switch (PubMed:26322679). Interacts with TMEM178A (By similarity). Interacts with CASQ1 (via C-terminal end and preferentially with the monomeric form); this interaction increases in response to a depletion of intracellular calcium, decreases both STIM1 aggregation and clustering, interaction of STIM1 with ORAI1 and store-operated Ca2+ entry (SOCE) activity (PubMed:27185316). Interacts with ADCY8 (PubMed:22494970).By similarity19 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112662, 29 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13586

Database of interacting proteins

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DIPi
DIP-31121N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q13586

Protein interaction database and analysis system

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IntActi
Q13586, 37 interactors

Molecular INTeraction database

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MINTi
Q13586

STRING: functional protein association networks

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STRINGi
9606.ENSP00000300737

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1685
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K60NMR-A58-201[»]
2MAJNMR-A/C312-387[»]
2MAKNMR-A/C312-387[»]
3TEQX-ray1.90A/B/C/D344-444[»]
4O9BX-ray2.60A/B/C/D237-340[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13586

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13586

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q13586

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 98EF-handAdd BLAST36
Domaini132 – 200SAMPROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni334 – 444SOAR/CADAdd BLAST111

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili248 – 4423 PublicationsAdd BLAST195

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi642 – 645Microtubule tip localization signal4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi270 – 336Glu-richAdd BLAST67
Compositional biasi600 – 629Pro/Ser-richAdd BLAST30
Compositional biasi672 – 685Lys-richAdd BLAST14

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.1 Publication
The STIM1 Orai1-activating region/CRAC-activating domain (SOAR/CAD) mediates interaction with ORAI1 to activate the channel.1 Publication

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4403 Eukaryota
ENOG410XRM6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261647

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054652

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13586

KEGG Orthology (KO)

More...
KOi
K16059

Database of Orthologous Groups

More...
OrthoDBi
1203627at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13586

TreeFam database of animal gene trees

More...
TreeFami
TF313487

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09573 SAM_STIM1, 1 hit
cd11722 SOAR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR032393 SOAR
IPR037608 STIM
IPR037609 STIM1_SAM
IPR030463 STM1

The PANTHER Classification System

More...
PANTHERi
PTHR15136 PTHR15136, 1 hit
PTHR15136:SF9 PTHR15136:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07647 SAM_2, 1 hit
PF16533 SOAR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13586-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVCVRLALW LLWGLLLHQG QSLSHSHSEK ATGTSSGANS EESTAAEFCR
60 70 80 90 100
IDKPLCHSED EKLSFEAVRN IHKLMDDDAN GDVDVEESDE FLREDLNYHD
110 120 130 140 150
PTVKHSTFHG EDKLISVEDL WKAWKSSEVY NWTVDEVVQW LITYVELPQY
160 170 180 190 200
EETFRKLQLS GHAMPRLAVT NTTMTGTVLK MTDRSHRQKL QLKALDTVLF
210 220 230 240 250
GPPLLTRHNH LKDFMLVVSI VIGVGGCWFA YIQNRYSKEH MKKMMKDLEG
260 270 280 290 300
LHRAEQSLHD LQERLHKAQE EHRTVEVEKV HLEKKLRDEI NLAKQEAQRL
310 320 330 340 350
KELREGTENE RSRQKYAEEE LEQVREALRK AEKELESHSS WYAPEALQKW
360 370 380 390 400
LQLTHEVEVQ YYNIKKQNAE KQLLVAKEGA EKIKKKRNTL FGTFHVAHSS
410 420 430 440 450
SLDDVDHKIL TAKQALSEVT AALRERLHRW QQIEILCGFQ IVNNPGIHSL
460 470 480 490 500
VAALNIDPSW MGSTRPNPAH FIMTDDVDDM DEEIVSPLSM QSPSLQSSVR
510 520 530 540 550
QRLTEPQHGL GSQRDLTHSD SESSLHMSDR QRVAPKPPQM SRAADEALNA
560 570 580 590 600
MTSNGSHRLI EGVHPGSLVE KLPDSPALAK KALLALNHGL DKAHSLMELS
610 620 630 640 650
PSAPPGGSPH LDSSRSHSPS SPDPDTPSPV GDSRALQASR NTRIPHLAGK
660 670 680
KAVAEEDNGS IGEETDSSPG RKKFPLKIFK KPLKK
Length:685
Mass (Da):77,423
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFB5E7CB3D68A7A6
GO
Isoform 2 (identifier: Q13586-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-540: DLTHSDSESSLHMSDRQRVAPKPPQM → GSSLKANRLSSKGFDPFRFGVLPPHE
     541-685: Missing.

Note: No experimental confirmation available.
Show »
Length:540
Mass (Da):62,133
Checksum:i2470E8D059BFF6FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G0XQ39G0XQ39_HUMAN
STIM1L
STIM1
791Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNJ4E9PNJ4_HUMAN
Stromal interaction molecule 1
STIM1
512Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDB2H0YDB2_HUMAN
Stromal interaction molecule 1
STIM1
405Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIQ8E9PIQ8_HUMAN
Stromal interaction molecule 1
STIM1
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN27E9PN27_HUMAN
Stromal interaction molecule 1
STIM1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRZ7E9PRZ7_HUMAN
Stromal interaction molecule 1
STIM1
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR09E9PR09_HUMAN
Stromal interaction molecule 1
STIM1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ19E9PJ19_HUMAN
Stromal interaction molecule 1
STIM1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMB4E9PMB4_HUMAN
Stromal interaction molecule 1
STIM1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR07E9PR07_HUMAN
Stromal interaction molecule 1
STIM1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti505E → G in AK314928 (PubMed:14702039).Curated1
Sequence conflicti556S → R in AAC51627 (PubMed:8921403).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06989272H → Q in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 PublicationCorresponds to variant dbSNP:rs397515436EnsemblClinVar.1
Natural variantiVAR_07561980N → T in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 PublicationCorresponds to variant dbSNP:rs748277951EnsemblClinVar.1
Natural variantiVAR_07562081G → D in TAM1; increases store-operated Ca(2+) influx. 1 Publication1
Natural variantiVAR_06989384D → G in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 PublicationCorresponds to variant dbSNP:rs397514675EnsemblClinVar.1
Natural variantiVAR_07562196L → V in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 Publication1
Natural variantiVAR_075622108F → I in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 Publication1
Natural variantiVAR_075623108F → L in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 1 Publication1
Natural variantiVAR_069894109H → N in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 2 PublicationsCorresponds to variant dbSNP:rs397514676EnsemblClinVar.1
Natural variantiVAR_069895109H → R in TAM1; myoblasts with the mutation have significantly increased clustering of STIM1, regardless of calcium levels, indicating that calcium sensing in the sarcoplasmic reticulum is impaired. 2 PublicationsCorresponds to variant dbSNP:rs397514677EnsemblClinVar.1
Natural variantiVAR_074037115I → F in STRMK and TAM1. 2 PublicationsCorresponds to variant dbSNP:rs527236030EnsemblClinVar.1
Natural variantiVAR_071476304R → W in STRMK; autosomal dominant; promotes constitutive activation of the Ca(2+) release-activated Ca(2+) (CRAC) channel. 3 PublicationsCorresponds to variant dbSNP:rs483352867EnsemblClinVar.1
Natural variantiVAR_071477426R → C Probable disease-associated mutation found in a patient with autosomal recessive hypomaturation enamel malformations, nail dysplasia and frequent throat infections. 1 PublicationCorresponds to variant dbSNP:rs1057519505Ensembl.1
Natural variantiVAR_069896429R → C in IMD10. 1 PublicationCorresponds to variant dbSNP:rs397514671EnsemblClinVar.1
Natural variantiVAR_061878538P → S. Corresponds to variant dbSNP:rs35960304EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055150515 – 540DLTHS…KPPQM → GSSLKANRLSSKGFDPFRFG VLPPHE in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_055151541 – 685Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U52426 mRNA Translation: AAC51627.1
AK314928 mRNA No translation available.
AC015689 Genomic DNA No translation available.
AC087441 Genomic DNA No translation available.
AC090587 Genomic DNA No translation available.
AC090804 Genomic DNA No translation available.
AC107970 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02581.1
BC021300 mRNA Translation: AAH21300.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS60706.1 [Q13586-2]
CCDS7749.1 [Q13586-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001264891.1, NM_001277962.1 [Q13586-2]
NP_003147.2, NM_003156.3 [Q13586-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.501735
Hs.657794

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300737; ENSP00000300737; ENSG00000167323 [Q13586-1]
ENST00000527651; ENSP00000436208; ENSG00000167323 [Q13586-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6786

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6786

UCSC genome browser

More...
UCSCi
uc001lyv.3 human [Q13586-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52426 mRNA Translation: AAC51627.1
AK314928 mRNA No translation available.
AC015689 Genomic DNA No translation available.
AC087441 Genomic DNA No translation available.
AC090587 Genomic DNA No translation available.
AC090804 Genomic DNA No translation available.
AC107970 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02581.1
BC021300 mRNA Translation: AAH21300.1
CCDSiCCDS60706.1 [Q13586-2]
CCDS7749.1 [Q13586-1]
RefSeqiNP_001264891.1, NM_001277962.1 [Q13586-2]
NP_003147.2, NM_003156.3 [Q13586-1]
UniGeneiHs.501735
Hs.657794

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K60NMR-A58-201[»]
2MAJNMR-A/C312-387[»]
2MAKNMR-A/C312-387[»]
3TEQX-ray1.90A/B/C/D344-444[»]
4O9BX-ray2.60A/B/C/D237-340[»]
ProteinModelPortaliQ13586
SMRiQ13586
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112662, 29 interactors
CORUMiQ13586
DIPiDIP-31121N
ELMiQ13586
IntActiQ13586, 37 interactors
MINTiQ13586
STRINGi9606.ENSP00000300737

Chemistry databases

ChEMBLiCHEMBL3832644

Protein family/group databases

TCDBi1.A.52.1.1 the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family

PTM databases

GlyConnecti1771
iPTMnetiQ13586
PhosphoSitePlusiQ13586

Polymorphism and mutation databases

BioMutaiSTIM1
DMDMi209572721

Proteomic databases

EPDiQ13586
jPOSTiQ13586
MaxQBiQ13586
PaxDbiQ13586
PeptideAtlasiQ13586
PRIDEiQ13586
ProteomicsDBi59584

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6786
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300737; ENSP00000300737; ENSG00000167323 [Q13586-1]
ENST00000527651; ENSP00000436208; ENSG00000167323 [Q13586-2]
GeneIDi6786
KEGGihsa:6786
UCSCiuc001lyv.3 human [Q13586-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6786
DisGeNETi6786
EuPathDBiHostDB:ENSG00000167323.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
STIM1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0009379
HGNCiHGNC:11386 STIM1
HPAiCAB037128
CAB037288
HPA011088
HPA012123
MalaCardsiSTIM1
MIMi160565 phenotype
185070 phenotype
605921 gene
612783 phenotype
neXtProtiNX_Q13586
OpenTargetsiENSG00000167323
Orphaneti317430 Combined immunodeficiency due to STIM1 deficiency
3204 Stormorken-Sjaastad-Langslet syndrome
2593 Tubular aggregate myopathy
PharmGKBiPA36195

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4403 Eukaryota
ENOG410XRM6 LUCA
GeneTreeiENSGT00390000000214
HOGENOMiHOG000261647
HOVERGENiHBG054652
InParanoidiQ13586
KOiK16059
OrthoDBi1203627at2759
PhylomeDBiQ13586
TreeFamiTF313487

Enzyme and pathway databases

ReactomeiR-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-5578775 Ion homeostasis
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SIGNORiQ13586

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
STIM1 human
EvolutionaryTraceiQ13586

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
STIM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6786

Protein Ontology

More...
PROi
PR:Q13586

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167323 Expressed in 192 organ(s), highest expression level in gastrocnemius
CleanExiHS_STIM1
ExpressionAtlasiQ13586 baseline and differential
GenevisibleiQ13586 HS

Family and domain databases

CDDicd09573 SAM_STIM1, 1 hit
cd11722 SOAR, 1 hit
InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR032393 SOAR
IPR037608 STIM
IPR037609 STIM1_SAM
IPR030463 STM1
PANTHERiPTHR15136 PTHR15136, 1 hit
PTHR15136:SF9 PTHR15136:SF9, 1 hit
PfamiView protein in Pfam
PF07647 SAM_2, 1 hit
PF16533 SOAR, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTIM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13586
Secondary accession number(s): E9PQJ4, Q8N382
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 14, 2008
Last modified: January 16, 2019
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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