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Protein

Melatonin-related receptor

Gene

GPR50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not bind melatonin.

GO - Molecular functioni

  • G protein-coupled receptor activity Source: ProtInc
  • identical protein binding Source: IntAct
  • melatonin receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin-related receptor
Alternative name(s):
G protein-coupled receptor 50
H9
Gene namesi
Name:GPR50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102195.8
HGNCiHGNC:4506 GPR50
MIMi300207 gene
neXtProtiNX_Q13585

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 64CytoplasmicSequence analysisAdd BLAST13
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 103ExtracellularSequence analysisAdd BLAST18
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 188ExtracellularSequence analysisAdd BLAST24
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini210 – 239CytoplasmicSequence analysisAdd BLAST30
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 273ExtracellularSequence analysisAdd BLAST13
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 617CytoplasmicSequence analysisAdd BLAST323

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9248
OpenTargetsiENSG00000102195
PharmGKBiPA28895

Chemistry databases

ChEMBLiCHEMBL3341577

Polymorphism and mutation databases

BioMutaiGPR50
DMDMi296439298

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698781 – 617Melatonin-related receptorAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi101 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ13585
MaxQBiQ13585
PaxDbiQ13585
PeptideAtlasiQ13585
PRIDEiQ13585
ProteomicsDBi59583

PTM databases

iPTMnetiQ13585
PhosphoSitePlusiQ13585

Expressioni

Tissue specificityi

Hypothalamus and pituitary.

Gene expression databases

BgeeiENSG00000102195 Expressed in 18 organ(s), highest expression level in adenohypophysis
CleanExiHS_GPR50
GenevisibleiQ13585 HS

Organism-specific databases

HPAiHPA049862
HPA054678

Interactioni

Subunit structurei

Homodimer, and heterodimer with MTNR1A and MTNR1B.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114674, 30 interactors
IntActiQ13585, 4 interactors
MINTiQ13585
STRINGi9606.ENSP00000218316

Structurei

3D structure databases

ProteinModelPortaliQ13585
SMRiQ13585
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi315 – 612Pro-richAdd BLAST298

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY Eukaryota
ENOG4111ZZV LUCA
GeneTreeiENSGT00440000033318
HOGENOMiHOG000133094
HOVERGENiHBG052529
InParanoidiQ13585
KOiK04287
OMAiQPDYPPA
OrthoDBiEOG091G0GO0
PhylomeDBiQ13585
TreeFamiTF331693

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002280 Mel_rcpt_1X
IPR000025 Melatonin_rcpt
PANTHERiPTHR45535 PTHR45535, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01151 MELATONIN1XR
PR00857 MELATONINR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q13585-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPTLAVPTP YGCIGCKLPQ PEYPPALIIF MFCAMVITIV VDLIGNSMVI
60 70 80 90 100
LAVTKNKKLR NSGNIFVVSL SVADMLVAIY PYPLMLHAMS IGGWDLSQLQ
110 120 130 140 150
CQMVGFITGL SVVGSIFNIV AIAINRYCYI CHSLQYERIF SVRNTCIYLV
160 170 180 190 200
ITWIMTVLAV LPNMYIGTIE YDPRTYTCIF NYLNNPVFTV TIVCIHFVLP
210 220 230 240 250
LLIVGFCYVR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF VIFLLFAVCW
260 270 280 290 300
CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN
310 320 330 340 350
FRREYWTIFH AMRHPIIFFS GLISDIREMQ EARTLARARA HARDQAREQD
360 370 380 390 400
RAHACPAVEE TPMNVRNVPL PGDAAAGHPD RASGHPKPHS RSSSAYRKSA
410 420 430 440 450
STHHKSVFSH SKAASGHLKP VSGHSKPASG HPKSATVYPK PASVHFKADS
460 470 480 490 500
VHFKGDSVHF KPDSVHFKPA SSNPKPITGH HVSAGSHSKS AFSAATSHPK
510 520 530 540 550
PTTGHIKPAT SHAEPTTADY PKPATTSHPK PTAADNPELS ASHCPEIPAI
560 570 580 590 600
AHPVSDDSDL PESASSPAAG PTKPAASQLE SDTIADLPDP TVVTTSTNDY
610
HDVVVIDVED DPDEMAV
Length:617
Mass (Da):67,369
Last modified:May 18, 2010 - v3
Checksum:iA0B73A7ACE1053BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti320S → P in AAC50614 (PubMed:8647286).Curated1
Sequence conflicti448A → G in AAC50614 (PubMed:8647286).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062254502 – 505Missing Lower fasting circulating triglyceride levels. 3 Publications4
Natural variantiVAR_062255532T → A Higher fasting circulating triglyceride levels. 3 PublicationsCorresponds to variant dbSNP:rs561077Ensembl.1
Natural variantiVAR_062256606I → V Higher fasting circulating triglyceride levels. 2 PublicationsCorresponds to variant dbSNP:rs13440581Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52219 mRNA Translation: AAC50614.1
EU432118 mRNA Translation: ABY87917.1
BC103696 mRNA Translation: AAI03697.1
BC105683 mRNA Translation: AAI05684.1
BC105684 mRNA Translation: AAI05685.1
CCDSiCCDS44012.1
PIRiS70520
RefSeqiNP_004215.2, NM_004224.3
UniGeneiHs.567390

Genome annotation databases

EnsembliENST00000218316; ENSP00000218316; ENSG00000102195
GeneIDi9248
KEGGihsa:9248
UCSCiuc010ntg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52219 mRNA Translation: AAC50614.1
EU432118 mRNA Translation: ABY87917.1
BC103696 mRNA Translation: AAI03697.1
BC105683 mRNA Translation: AAI05684.1
BC105684 mRNA Translation: AAI05685.1
CCDSiCCDS44012.1
PIRiS70520
RefSeqiNP_004215.2, NM_004224.3
UniGeneiHs.567390

3D structure databases

ProteinModelPortaliQ13585
SMRiQ13585
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114674, 30 interactors
IntActiQ13585, 4 interactors
MINTiQ13585
STRINGi9606.ENSP00000218316

Chemistry databases

ChEMBLiCHEMBL3341577

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ13585
PhosphoSitePlusiQ13585

Polymorphism and mutation databases

BioMutaiGPR50
DMDMi296439298

Proteomic databases

EPDiQ13585
MaxQBiQ13585
PaxDbiQ13585
PeptideAtlasiQ13585
PRIDEiQ13585
ProteomicsDBi59583

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218316; ENSP00000218316; ENSG00000102195
GeneIDi9248
KEGGihsa:9248
UCSCiuc010ntg.3 human

Organism-specific databases

CTDi9248
DisGeNETi9248
EuPathDBiHostDB:ENSG00000102195.8
GeneCardsiGPR50
H-InvDBiHIX0056463
HGNCiHGNC:4506 GPR50
HPAiHPA049862
HPA054678
MIMi300207 gene
neXtProtiNX_Q13585
OpenTargetsiENSG00000102195
PharmGKBiPA28895
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHFY Eukaryota
ENOG4111ZZV LUCA
GeneTreeiENSGT00440000033318
HOGENOMiHOG000133094
HOVERGENiHBG052529
InParanoidiQ13585
KOiK04287
OMAiQPDYPPA
OrthoDBiEOG091G0GO0
PhylomeDBiQ13585
TreeFamiTF331693

Miscellaneous databases

GeneWikiiGPR50
GenomeRNAii9248
PROiPR:Q13585
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102195 Expressed in 18 organ(s), highest expression level in adenohypophysis
CleanExiHS_GPR50
GenevisibleiQ13585 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002280 Mel_rcpt_1X
IPR000025 Melatonin_rcpt
PANTHERiPTHR45535 PTHR45535, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01151 MELATONIN1XR
PR00857 MELATONINR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTR1L_HUMAN
AccessioniPrimary (citable) accession number: Q13585
Secondary accession number(s): Q0VGG3, Q3ZAR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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