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Entry version 187 (16 Oct 2019)
Sequence version 4 (23 Mar 2010)
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Protein

Ras GTPase-activating-like protein IQGAP2

Gene

IQGAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras GTPase-activating-like protein IQGAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IQGAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6111 IQGAP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605401 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13576

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10788

Open Targets

More...
OpenTargetsi
ENSG00000145703

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29911

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13576

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IQGAP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
292495090

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000566501 – 1575Ras GTPase-activating-like protein IQGAP2Add BLAST1575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineCombined sources1
Modified residuei356PhosphothreonineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei716PhosphothreonineCombined sources1
Modified residuei782PhosphothreonineCombined sources1
Modified residuei881PhosphothreonineBy similarity1
Modified residuei1002PhosphothreonineCombined sources1
Modified residuei1269PhosphothreonineCombined sources1
Modified residuei1271PhosphoserineCombined sources1
Modified residuei1279PhosphoserineCombined sources1
Modified residuei1358PhosphoserineCombined sources1
Modified residuei1461PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13576

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13576

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13576

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13576

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13576

PeptideAtlas

More...
PeptideAtlasi
Q13576

PRoteomics IDEntifications database

More...
PRIDEi
Q13576

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59581 [Q13576-1]
59582 [Q13576-2]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
Q13576

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q13576

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13576

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13576

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 expression is enhanced in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145703 Expressed in 183 organ(s), highest expression level in metanephric glomerulus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13576 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13576 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004241
HPA037403
HPA037404

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116004, 36 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q13576

Database of interacting proteins

More...
DIPi
DIP-27542N

Protein interaction database and analysis system

More...
IntActi
Q13576, 28 interactors

Molecular INTeraction database

More...
MINTi
Q13576

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000274364

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13576

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13576

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 156Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST116
Domaini594 – 627WWPROSITE-ProRule annotationAdd BLAST34
Domaini690 – 719IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini720 – 749IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini750 – 779IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini917 – 1150Ras-GAPPROSITE-ProRule annotationAdd BLAST234

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi263 – 266Poly-Lys4

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2128 Eukaryota
COG5261 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183076

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000004842

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13576

KEGG Orthology (KO)

More...
KOi
K05767

Identification of Orthologs from Complete Genome Data

More...
OMAi
QFRHSDN

Database of Orthologous Groups

More...
OrthoDBi
674320at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13576

TreeFam database of animal gene trees

More...
TreeFami
TF313078

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR000048 IQ_motif_EF-hand-BS
IPR000593 RasGAP_C
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001202 WW_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF00612 IQ, 2 hits
PF00616 RasGAP, 1 hit
PF03836 RasGAP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00015 IQ, 3 hits
SM00323 RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS50096 IQ, 3 hits
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13576-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW
60 70 80 90 100
MEVCLVEELP PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY
110 120 130 140 150
KKSGLHFRHT DNTVQWLRAM ESIGLPKIFY PETTDVYDRK NIPRMIYCIH
160 170 180 190 200
ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS NMRKELEKYG IQMPSFSKIG
210 220 230 240 250
GILANELSVD EAALHAAVIA INEAVEKGIA EQTVVTLRNP NAVLTLVDDN
260 270 280 290 300
LAPEYQKELW DAKKKKEENA RLKNSCISEE ERDAYEELLT QAEIQGNINK
310 320 330 340 350
VNRQAAVDHI NAVIPEGDPE NTLLALKKPE AQLPAVYPFA AAMYQNELFN
360 370 380 390 400
LQKQNTMNYL AHEELLIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPAIG
410 420 430 440 450
LNNLDKAYVE RYANTLLSVK LEVLSQGQDN LSWNEIQNCI DMVNAQIQEE
460 470 480 490 500
NDRVVAVGYI NEAIDEGNPL RTLETLLLPT ANISDVDPAH AQHYQDVLYH
510 520 530 540 550
AKSQKLGDSE SVSKVLWLDE IQQAVDDANV DKDRAKQWVT LVVDVNQCLE
560 570 580 590 600
GKKSSDILSV LKSSTSNAND IIPECADKYY DALVKAKELK SERVSSDGSW
610 620 630 640 650
LKLNLHKKYD YYYNTDSKES SWVTPESCLY KESWLTGKEI EDIIEEVTVG
660 670 680 690 700
YIRENIWSAS EELLLRFQAT SSGPILREEF EARKSFLHEQ EENVVKIQAF
710 720 730 740 750
WKGYKQRKEY MHRRQTFIDN TDSIVKIQSW FRMATARKSY LSRLQYFRDH
760 770 780 790 800
NNEIVKIQSL LRANKARDDY KTLVGSENPP LTVIRKFVYL LDQSDLDFQE
810 820 830 840 850
ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEDVISHSK
860 870 880 890 900
KLNKKKGGEM EILNNTDNQG IKSLSKERRK TLETYQQLFY LLQTNPLYLA
910 920 930 940 950
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK
960 970 980 990 1000
VDQVQDIVTG NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIDDKSLII
1010 1020 1030 1040 1050
NTNPVEVYKA WVNQLETQTG EASKLPYDVT TEQALTYPEV KNKLEASIEN
1060 1070 1080 1090 1100
LRRVTDKVLN SIISSLDLLP YGLRYIAKVL KNSIHEKFPD ATEDELLKIV
1110 1120 1130 1140 1150
GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSDQRRNLGS VAKVLQHAAS
1160 1170 1180 1190 1200
NKLFEGENEH LSSMNNYLSE TYQEFRKYFK EACNVPEPEE KFNMDKYTDL
1210 1220 1230 1240 1250
VTVSKPVIYI SIEEIISTHS LLLEHQDAIA PEKNDLLSEL LGSLGEVPTV
1260 1270 1280 1290 1300
ESFLGEGAVD PNDPNKANTL SQLSKTEISL VLTSKYDIED GEAIDSRSLM
1310 1320 1330 1340 1350
IKTKKLIIDV IRNQPGNTLT EILETPATAQ QEVDHATDMV SRAMIDSRTP
1360 1370 1380 1390 1400
EEMKHSQSMI EDAQLPLEQK KRKIQRNLRT LEQTGHVSSE NKYQDILNEI
1410 1420 1430 1440 1450
AKDIRNQRIY RKLRKAELAK LQQTLNALNK KAAFYEEQIN YYDTYIKTCL
1460 1470 1480 1490 1500
DNLKRKNTRR SIKLDGKGEP KGAKRAKPVK YTAAKLHEKG VLLDIDDLQT
1510 1520 1530 1540 1550
NQFKNVTFDI IATEDVGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV
1560 1570
MKMFDKVKVN VNLLIYLLNK KFYGK
Length:1,575
Mass (Da):180,578
Last modified:March 23, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBCC8CED6645CB09B
GO
Isoform 2 (identifier: Q13576-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.
     448-453: QEENDR → MHSLPG
     642-698: Missing.

Show »
Length:1,071
Mass (Da):122,805
Checksum:i111C704267532C91
GO
Isoform 3 (identifier: Q13576-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.
     448-453: QEENDR → MGCFKG
     642-698: Missing.

Note: No experimental confirmation available.
Show »
Length:1,071
Mass (Da):122,806
Checksum:i1E59E4F49FB4D334
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWC2E7EWC2_HUMAN
Ras GTPase-activating-like protein ...
IQGAP2
1,402Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7S7F5H7S7_HUMAN
Ras GTPase-activating-like protein ...
IQGAP2
1,525Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PDT6E9PDT6_HUMAN
Ras GTPase-activating-like protein ...
IQGAP2
509Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA28H0YA28_HUMAN
Ras GTPase-activating-like protein ...
IQGAP2
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R939D6R939_HUMAN
Ras GTPase-activating-like protein ...
IQGAP2
824Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGC6D6RGC6_HUMAN
Ras GTPase-activating-like protein ...
IQGAP2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDK8D6RDK8_HUMAN
Ras GTPase-activating-like protein ...
IQGAP2
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R999D6R999_HUMAN
Ras GTPase-activating-like protein ...
IQGAP2
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti95V → E in BAF83755 (PubMed:14702039).Curated1
Sequence conflicti778N → S in BAF83755 (PubMed:14702039).Curated1
Sequence conflicti1101G → R in BAF83755 (PubMed:14702039).Curated1
Sequence conflicti1333V → L in BAH13890 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055823455V → A. Corresponds to variant dbSNP:rs7722711Ensembl.1
Natural variantiVAR_055824479P → R. Corresponds to variant dbSNP:rs3822530Ensembl.1
Natural variantiVAR_062958527D → E3 PublicationsCorresponds to variant dbSNP:rs2431352Ensembl.1
Natural variantiVAR_059292532K → E3 PublicationsCorresponds to variant dbSNP:rs2909888Ensembl.1
Natural variantiVAR_062959629L → FCombined sources2 PublicationsCorresponds to variant dbSNP:rs2455230Ensembl.1
Natural variantiVAR_055825714R → W. Corresponds to variant dbSNP:rs35366349Ensembl.1
Natural variantiVAR_062960724I → V2 PublicationsCorresponds to variant dbSNP:rs2431363Ensembl.1
Natural variantiVAR_055826894T → I. Corresponds to variant dbSNP:rs34950321Ensembl.1
Natural variantiVAR_0558271052R → I. Corresponds to variant dbSNP:rs2287932Ensembl.1
Natural variantiVAR_0558281184N → S. Corresponds to variant dbSNP:rs10454915Ensembl.1
Natural variantiVAR_0558291379R → W. Corresponds to variant dbSNP:rs17681908Ensembl.1
Natural variantiVAR_0694341445Y → C1 PublicationCorresponds to variant dbSNP:rs369078465Ensembl.1
Natural variantiVAR_0694351530M → I1 PublicationCorresponds to variant dbSNP:rs150409607Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0106291 – 447Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST447
Alternative sequenceiVSP_010630448 – 453QEENDR → MHSLPG in isoform 2. 1 Publication6
Alternative sequenceiVSP_055149448 – 453QEENDR → MGCFKG in isoform 3. 1 Publication6
Alternative sequenceiVSP_010631642 – 698Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U51903 mRNA Translation: AAB37765.1
AY351902 mRNA Translation: AAQ81291.1
AK291066 mRNA Translation: BAF83755.1
AK303054 mRNA Translation: BAH13890.1
AC025188 Genomic DNA No translation available.
AC026706 Genomic DNA No translation available.
AC026725 Genomic DNA No translation available.
AC093251 Genomic DNA No translation available.
AC112173 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34188.1 [Q13576-1]
CCDS68897.1 [Q13576-2]
CCDS68898.1 [Q13576-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001272389.1, NM_001285460.1
NP_001272390.1, NM_001285461.1
NP_001272391.1, NM_001285462.1
NP_006624.2, NM_006633.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000274364; ENSP00000274364; ENSG00000145703 [Q13576-1]
ENST00000396234; ENSP00000379535; ENSG00000145703 [Q13576-2]
ENST00000502745; ENSP00000426027; ENSG00000145703 [Q13576-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10788

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10788

UCSC genome browser

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UCSCi
uc003kek.5 human [Q13576-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51903 mRNA Translation: AAB37765.1
AY351902 mRNA Translation: AAQ81291.1
AK291066 mRNA Translation: BAF83755.1
AK303054 mRNA Translation: BAH13890.1
AC025188 Genomic DNA No translation available.
AC026706 Genomic DNA No translation available.
AC026725 Genomic DNA No translation available.
AC093251 Genomic DNA No translation available.
AC112173 Genomic DNA No translation available.
CCDSiCCDS34188.1 [Q13576-1]
CCDS68897.1 [Q13576-2]
CCDS68898.1 [Q13576-3]
RefSeqiNP_001272389.1, NM_001285460.1
NP_001272390.1, NM_001285461.1
NP_001272391.1, NM_001285462.1
NP_006624.2, NM_006633.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IEZX-ray1.50A/B1476-1571[»]
4EZAX-ray1.50A/B1476-1571[»]
5CJPX-ray2.60E/F875-1258[»]
SMRiQ13576
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116004, 36 interactors
CORUMiQ13576
DIPiDIP-27542N
IntActiQ13576, 28 interactors
MINTiQ13576
STRINGi9606.ENSP00000274364

PTM databases

CarbonylDBiQ13576
iPTMnetiQ13576
PhosphoSitePlusiQ13576

Polymorphism and mutation databases

BioMutaiIQGAP2
DMDMi292495090

2D gel databases

OGPiQ13576

Proteomic databases

EPDiQ13576
jPOSTiQ13576
MassIVEiQ13576
MaxQBiQ13576
PaxDbiQ13576
PeptideAtlasiQ13576
PRIDEiQ13576
ProteomicsDBi59581 [Q13576-1]
59582 [Q13576-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10788

Genome annotation databases

EnsembliENST00000274364; ENSP00000274364; ENSG00000145703 [Q13576-1]
ENST00000396234; ENSP00000379535; ENSG00000145703 [Q13576-2]
ENST00000502745; ENSP00000426027; ENSG00000145703 [Q13576-3]
GeneIDi10788
KEGGihsa:10788
UCSCiuc003kek.5 human [Q13576-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10788
DisGeNETi10788

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IQGAP2
HGNCiHGNC:6111 IQGAP2
HPAiCAB004241
HPA037403
HPA037404
MIMi605401 gene
neXtProtiNX_Q13576
OpenTargetsiENSG00000145703
PharmGKBiPA29911

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2128 Eukaryota
COG5261 LUCA
GeneTreeiENSGT00950000183076
HOGENOMiHOG000004842
InParanoidiQ13576
KOiK05767
OMAiQFRHSDN
OrthoDBi674320at2759
PhylomeDBiQ13576
TreeFamiTF313078

Enzyme and pathway databases

ReactomeiR-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IQGAP2 human
EvolutionaryTraceiQ13576

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IQGAP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10788
PharosiQ13576

Protein Ontology

More...
PROi
PR:Q13576

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145703 Expressed in 183 organ(s), highest expression level in metanephric glomerulus
ExpressionAtlasiQ13576 baseline and differential
GenevisibleiQ13576 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR000048 IQ_motif_EF-hand-BS
IPR000593 RasGAP_C
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001202 WW_dom
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00612 IQ, 2 hits
PF00616 RasGAP, 1 hit
PF03836 RasGAP_C, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00015 IQ, 3 hits
SM00323 RasGAP, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS50096 IQ, 3 hits
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIQGA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13576
Secondary accession number(s): A8K4V1, B7Z8A4, J3KR91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 23, 2010
Last modified: October 16, 2019
This is version 187 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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