DGKZ

Functionⁱ

Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity (PubMed:11257115). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Activates PIP5K1A activity via generation of phosphatidic acid (PubMed:15157668).By similarity2 Publications

Catalytic activityⁱ

a 1,2-diacyl-sn-glycerol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
a 1,2-diacyl-sn-glycero-3-phosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
EC:
2.7.1.107
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
a 1,2-diacyl-sn-glycerol
zoom
+
ATP
=
a 1,2-diacyl-sn-glycero-3-phosphate
zoom
+
ADP
+
H⁺

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	287 – 341	Phorbol-ester/DAG-type 1Add BLAST		55
Zinc fingerⁱ	361 – 419	Phorbol-ester/DAG-type 2Add BLAST		59

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Ligand	ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	2.7.1.107 2681
Reactomeⁱ	R-HSA-114508 Effects of PIP2 hydrolysis
SIGNORⁱ	Q13574

Chemistry databases

SwissLipidsⁱ	SLP:000000547 SLP:000000921 [Q13574-1] SLP:000000922 [Q13574-2]

SwissLipidsⁱ

SLP:000000547
SLP:000000921 [Q13574-1]
SLP:000000922 [Q13574-2]

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Diacylglycerol kinase zeta (EC:2.7.1.107) Short name: DAG kinase zeta Alternative name(s): Diglyceride kinase zeta Short name: DGK-zeta
Gene namesⁱ	Name:DGKZ Synonyms:DAGK6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149091.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2857 DGKZ
MIMⁱ	601441 gene
neXtProtⁱ	NX_Q13574

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	1115 – 1116	TA → NS: Loss of interaction with SNTG1. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8525
Open Targets More...OpenTargetsⁱ	ENSG00000149091
PharmGKBⁱ	PA27318

Miscellaneous databases

Pharosⁱ	Q13574 Tbio

Pharosⁱ

Q13574 Tbio

Chemistry databases

ChEMBLⁱ

CHEMBL4105942

Polymorphism and mutation databases

BioMutaⁱ	DGKZ
DMDMⁱ	215274170

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218468	1 – 1117	Diacylglycerol kinase zetaAdd BLAST		1117

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	894	PhosphoserineCombined sources		1
Modified residueⁱ	970	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q13574
jPOSTⁱ	Q13574
MassIVEⁱ	Q13574
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13574
PaxDbⁱ	Q13574
PeptideAtlas More...PeptideAtlasⁱ	Q13574
PRIDEⁱ	Q13574
ProteomicsDBⁱ	22840 32183 59578 [Q13574-1] 59579 [Q13574-2] 59580 [Q13574-3] 6789

PTM databases

iPTMnetⁱ	Q13574
PhosphoSitePlusⁱ	Q13574

Expressionⁱ

Tissue specificityⁱ

Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.

Gene expression databases

Bgeeⁱ	ENSG00000149091 Expressed in 102 organ(s), highest expression level in right frontal lobe
ExpressionAtlasⁱ	Q13574 baseline and differential
Genevisibleⁱ	Q13574 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051336

HPAⁱ

HPA051336

Interactionⁱ

Subunit structureⁱ

Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS (PubMed:11257115, PubMed:11352924, PubMed:17351151).

Interacts with IRS1 in the absence of insulin; insulin stimulation decreases this interaction (By similarity).

Found in a ternary complex with IRS1 and PIP5K1A in the absence of insulin (By similarity).

Interacts with PIP5K1A (PubMed:15157668).

By similarity4 Publications

Binary interactionsⁱ

Entry	#Exp.	IntAct
P06400	6	EBI-715527,EBI-491274
P28749	2	EBI-715527,EBI-971402
Q08999	2	EBI-715527,EBI-971439

Show more details

GO - Molecular functionⁱ

protein C-terminus binding
Source: UniProtKB
Inferred from direct assayⁱ
- "The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta."
  Los A.P., Vinke F.P., de Widt J., Topham M.K., van Blitterswijk W.J., Divecha N.
  J. Biol. Chem. 281:858-866(2006) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114095, 70 interactors
CORUMⁱ	Q13574
IntActⁱ	Q13574, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q13574
STRINGⁱ	9606.ENSP00000412178

Miscellaneous databases

RNActⁱ	Q13574 protein

RNActⁱ

Q13574 protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	1112 – 1116	Combined sources		5

Show more details

3D structure databases

SMRⁱ	Q13574
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	480 – 614	DAGKcPROSITE-ProRule annotationAdd BLAST	135
Repeatⁱ	1011 – 1041	ANK 1Add BLAST	31
Repeatⁱ	1046 – 1075	ANK 2Add BLAST	30

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	448 – 462	MARCKS homologyAdd BLAST		15
Regionⁱ	467 – 605	Mediates interaction with RASGRP1Add BLAST		139

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	550 – 558	Nuclear export signalBy similarity		9

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	256 – 261	Poly-Pro	6
Compositional biasⁱ	448 – 451	Poly-Lys	4
Compositional biasⁱ	560 – 563	Poly-Pro	4

Sequence similaritiesⁱ

Belongs to the eukaryotic diacylglycerol kinase family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	287 – 341	Phorbol-ester/DAG-type 1Add BLAST		55
Zinc fingerⁱ	361 – 419	Phorbol-ester/DAG-type 2Add BLAST		59

Keywords - Domainⁱ

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0782 Eukaryota ENOG410XSCB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156152
HOGENOMⁱ	HOG000231472
InParanoidⁱ	Q13574
KEGG Orthology (KO) More...KOⁱ	K00901
OMAⁱ	LQHMVAQ
Database of Orthologous Groups More...OrthoDBⁱ	274339at2759
PhylomeDBⁱ	Q13574
TreeFamⁱ	TF312817

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00029 C1, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit 3.40.50.10330, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR017438 ATP-NAD_kinase_N IPR037607 DGK IPR000756 Diacylglycerol_kin_accessory IPR001206 Diacylglycerol_kinase_cat_dom IPR016064 NAD/diacylglycerol_kinase_sf IPR002219 PE/DAG-bd
PANTHERⁱ	PTHR11255 PTHR11255, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF00130 C1_1, 1 hit PF00609 DAGK_acc, 1 hit PF00781 DAGK_cat, 1 hit
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits SM00109 C1, 2 hits SM00045 DAGKa, 1 hit SM00046 DAGKc, 1 hit
SUPFAMⁱ	SSF111331 SSF111331, 1 hit SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits PS50146 DAGK, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q13574-1) [UniParc]FASTA Add to basket

Also known as: Long, zeta2

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
METFFRRHFR GKVPGPGEGQ QRPSSVGLPT GKARRRSPAG QASSSLAQRR 
        60         70         80         90        100
RSSAQLQGCL LSCGVRAQGS SRRRSSTVPP SCNPRFIVDK VLTPQPTTVG 
       110        120        130        140        150
AQLLGAPLLL TGLVGMNEEE GVQEDVVAEA SSAIQPGTKT PGPPPPRGAQ 
       160        170        180        190        200
PLLPLPRYLR RASSHLLPAD AVYDHALWGL HGYYRRLSQR RPSGQHPGPG 
       210        220        230        240        250
GRRASGTTAG TMLPTRVRPL SRRRQVALRR KAAGPQAWSA LLAKAITKSG 
       260        270        280        290        300
LQHLAPPPPT PGAPCSESER QIRSTVDWSE SATYGEHIWF ETNVSGDFCY 
       310        320        330        340        350
VGEQYCVARM LKSVSRRKCA ACKIVVHTPC IEQLEKINFR CKPSFRESGS 
       360        370        380        390        400
RNVREPTFVR HHWVHRRRQD GKCRHCGKGF QQKFTFHSKE IVAISCSWCK 
       410        420        430        440        450
QAYHSKVSCF MLQQIEEPCS LGVHAAVVIP PTWILRARRP QNTLKASKKK 
       460        470        480        490        500
KRASFKRKSS KKGPEEGRWR PFIIRPTPSP LMKPLLVFVN PKSGGNQGAK 
       510        520        530        540        550
IIQSFLWYLN PRQVFDLSQG GPKEALEMYR KVHNLRILAC GGDGTVGWIL 
       560        570        580        590        600
STLDQLRLKP PPPVAILPLG TGNDLARTLN WGGGYTDEPV SKILSHVEEG 
       610        620        630        640        650
NVVQLDRWDL HAEPNPEAGP EDRDEGATDR LPLDVFNNYF SLGFDAHVTL 
       660        670        680        690        700
EFHESREANP EKFNSRFRNK MFYAGTAFSD FLMGSSKDLA KHIRVVCDGM 
       710        720        730        740        750
DLTPKIQDLK PQCVVFLNIP RYCAGTMPWG HPGEHHDFEP QRHDDGYLEV 
       760        770        780        790        800
IGFTMTSLAA LQVGGHGERL TQCREVVLTT SKAIPVQVDG EPCKLAASRI 
       810        820        830        840        850
RIALRNQATM VQKAKRRSAA PLHSDQQPVP EQLRIQVSRV SMHDYEALHY 
       860        870        880        890        900
DKEQLKEASV PLGTVVVPGD SDLELCRAHI ERLQQEPDGA GAKSPTCQKL 
       910        920        930        940        950
SPKWCFLDAT TASRFYRIDR AQEHLNYVTE IAQDEIYILD PELLGASARP 
       960        970        980        990       1000
DLPTPTSPLP TSPCSPTPRS LQGDAAPPQG EELIEAAKRN DFCKLQELHR 
      1010       1020       1030       1040       1050
AGGDLMHRDE QSRTLLHHAV STGSKDVVRY LLDHAPPEIL DAVEENGETC 
      1060       1070       1080       1090       1100
LHQAAALGQR TICHYIVEAG ASLMKTDQQG DTPRQRAEKA QDTELAAYLE 
      1110 
NRQHYQMIQR EDQETAV

Note: Minor isoform.

Length:1,117

Mass (Da):124,128

Last modified:November 25, 2008 - v3

Checksum:ⁱF3A7C2382ECF549B

GO

Isoform 2 (identifier: Q13574-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR

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        10         20         30         40         50
MEPRDGSPEA RSSDSESASA SSSGSERDAG PEPDKAPRRL NKRRFPGLRL 
        60         70         80         90        100
FGHRKAITKS GLQHLAPPPP TPGAPCSESE RQIRSTVDWS ESATYGEHIW 
       110        120        130        140        150
FETNVSGDFC YVGEQYCVAR MLKSVSRRKC AACKIVVHTP CIEQLEKINF 
       160        170        180        190        200
RCKPSFRESG SRNVREPTFV RHHWVHRRRQ DGKCRHCGKG FQQKFTFHSK 
       210        220        230        240        250
EIVAISCSWC KQAYHSKVSC FMLQQIEEPC SLGVHAAVVI PPTWILRARR 
       260        270        280        290        300
PQNTLKASKK KKRASFKRKS SKKGPEEGRW RPFIIRPTPS PLMKPLLVFV 
       310        320        330        340        350
NPKSGGNQGA KIIQSFLWYL NPRQVFDLSQ GGPKEALEMY RKVHNLRILA 
       360        370        380        390        400
CGGDGTVGWI LSTLDQLRLK PPPPVAILPL GTGNDLARTL NWGGGYTDEP 
       410        420        430        440        450
VSKILSHVEE GNVVQLDRWD LHAEPNPEAG PEDRDEGATD RLPLDVFNNY 
       460        470        480        490        500
FSLGFDAHVT LEFHESREAN PEKFNSRFRN KMFYAGTAFS DFLMGSSKDL 
       510        520        530        540        550
AKHIRVVCDG MDLTPKIQDL KPQCVVFLNI PRYCAGTMPW GHPGEHHDFE 
       560        570        580        590        600
PQRHDDGYLE VIGFTMTSLA ALQVGGHGER LTQCREVVLT TSKAIPVQVD 
       610        620        630        640        650
GEPCKLAASR IRIALRNQAT MVQKAKRRSA APLHSDQQPV PEQLRIQVSR 
       660        670        680        690        700
VSMHDYEALH YDKEQLKEAS VPLGTVVVPG DSDLELCRAH IERLQQEPDG 
       710        720        730        740        750
AGAKSPTCQK LSPKWCFLDA TTASRFYRID RAQEHLNYVT EIAQDEIYIL 
       760        770        780        790        800
DPELLGASAR PDLPTPTSPL PTSPCSPTPR SLQGDAAPPQ GEELIEAAKR 
       810        820        830        840        850
NDFCKLQELH RAGGDLMHRD EQSRTLLHHA VSTGSKDVVR YLLDHAPPEI 
       860        870        880        890        900
LDAVEENGET CLHQAAALGQ RTICHYIVEA GASLMKTDQQ GDTPRQRAEK 
       910        920 
AQDTELAAYL ENRQHYQMIQ REDQETAV

Note: Major isoform.Curated

Show »

Length:928

Mass (Da):103,981

Checksum:ⁱ7936A979CB3D35AA

GO

Isoform 3 (identifier: Q13574-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-71: METFFRRHFR...SCGVRAQGSS → MAEGQGGGGQ...LHLRKQVSYR
72-243: Missing.

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        10         20         30         40         50
MAEGQGGGGQ RWDWAGGGRA AEEEVVRRRC RRGEEAQVAQ PWPEGSRGTA 
        60         70         80         90        100
AGPPVEERFR QLHLRKQVSY RKAITKSGLQ HLAPPPPTPG APCSESERQI 
       110        120        130        140        150
RSTVDWSESA TYGEHIWFET NVSGDFCYVG EQYCVARMLK SVSRRKCAAC 
       160        170        180        190        200
KIVVHTPCIE QLEKINFRCK PSFRESGSRN VREPTFVRHH WVHRRRQDGK 
       210        220        230        240        250
CRHCGKGFQQ KFTFHSKEIV AISCSWCKQA YHSKVSCFML QQIEEPCSLG 
       260        270        280        290        300
VHAAVVIPPT WILRARRPQN TLKASKKKKR ASFKRKSSKK GPEEGRWRPF 
       310        320        330        340        350
IIRPTPSPLM KPLLVFVNPK SGGNQGAKII QSFLWYLNPR QVFDLSQGGP 
       360        370        380        390        400
KEALEMYRKV HNLRILACGG DGTVGWILST LDQLRLKPPP PVAILPLGTG 
       410        420        430        440        450
NDLARTLNWG GGYTDEPVSK ILSHVEEGNV VQLDRWDLHA EPNPEAGPED 
       460        470        480        490        500
RDEGATDRLP LDVFNNYFSL GFDAHVTLEF HESREANPEK FNSRFRNKMF 
       510        520        530        540        550
YAGTAFSDFL MGSSKDLAKH IRVVCDGMDL TPKIQDLKPQ CVVFLNIPRY 
       560        570        580        590        600
CAGTMPWGHP GEHHDFEPQR HDDGYLEVIG FTMTSLAALQ VGGHGERLTQ 
       610        620        630        640        650
CREVVLTTSK AIPVQVDGEP CKLAASRIRI ALRNQATMVQ KAKRRSAAPL 
       660        670        680        690        700
HSDQQPVPEQ LRIQVSRVSM HDYEALHYDK EQLKEASVPL GTVVVPGDSD 
       710        720        730        740        750
LELCRAHIER LQQEPDGAGA KSPTCQKLSP KWCFLDATTA SRFYRIDRAQ 
       760        770        780        790        800
EHLNYVTEIA QDEIYILDPE LLGASARPDL PTPTSPLPTS PCSPTPRSLQ 
       810        820        830        840        850
GDAAPPQGEE LIEAAKRNDF CKLQELHRAG GDLMHRDEQS RTLLHHAVST 
       860        870        880        890        900
GSKDVVRYLL DHAPPEILDA VEENGETCLH QAAALGQRTI CHYIVEAGAS 
       910        920        930        940 
LMKTDQQGDT PRQRAEKAQD TELAAYLENR QHYQMIQRED QETAV

Show »

Length:945

Mass (Da):106,030

Checksum:ⁱ6EF612B9FE91F7E7

GO

Isoform 4 (identifier: Q13574-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
311-311: L → LQ

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        10         20         30         40         50
MEPRDGSPEA RSSDSESASA SSSGSERDAG PEPDKAPRRL NKRRFPGLRL 
        60         70         80         90        100
FGHRKAITKS GLQHLAPPPP TPGAPCSESE RQIRSTVDWS ESATYGEHIW 
       110        120        130        140        150
FETNVSGDFC YVGEQYCVAR MLQKSVSRRK CAACKIVVHT PCIEQLEKIN 
       160        170        180        190        200
FRCKPSFRES GSRNVREPTF VRHHWVHRRR QDGKCRHCGK GFQQKFTFHS 
       210        220        230        240        250
KEIVAISCSW CKQAYHSKVS CFMLQQIEEP CSLGVHAAVV IPPTWILRAR 
       260        270        280        290        300
RPQNTLKASK KKKRASFKRK SSKKGPEEGR WRPFIIRPTP SPLMKPLLVF 
       310        320        330        340        350
VNPKSGGNQG AKIIQSFLWY LNPRQVFDLS QGGPKEALEM YRKVHNLRIL 
       360        370        380        390        400
ACGGDGTVGW ILSTLDQLRL KPPPPVAILP LGTGNDLART LNWGGGYTDE 
       410        420        430        440        450
PVSKILSHVE EGNVVQLDRW DLHAEPNPEA GPEDRDEGAT DRLPLDVFNN 
       460        470        480        490        500
YFSLGFDAHV TLEFHESREA NPEKFNSRFR NKMFYAGTAF SDFLMGSSKD 
       510        520        530        540        550
LAKHIRVVCD GMDLTPKIQD LKPQCVVFLN IPRYCAGTMP WGHPGEHHDF 
       560        570        580        590        600
EPQRHDDGYL EVIGFTMTSL AALQVGGHGE RLTQCREVVL TTSKAIPVQV 
       610        620        630        640        650
DGEPCKLAAS RIRIALRNQA TMVQKAKRRS AAPLHSDQQP VPEQLRIQVS 
       660        670        680        690        700
RVSMHDYEAL HYDKEQLKEA SVPLGTVVVP GDSDLELCRA HIERLQQEPD 
       710        720        730        740        750
GAGAKSPTCQ KLSPKWCFLD ATTASRFYRI DRAQEHLNYV TEIAQDEIYI 
       760        770        780        790        800
LDPELLGASA RPDLPTPTSP LPTSPCSPTP RSLQGDAAPP QGEELIEAAK 
       810        820        830        840        850
RNDFCKLQEL HRAGGDLMHR DEQSRTLLHH AVSTGSKDVV RYLLDHAPPE 
       860        870        880        890        900
ILDAVEENGE TCLHQAAALG QRTICHYIVE AGASLMKTDQ QGDTPRQRAE 
       910        920 
KAQDTELAAY LENRQHYQMI QREDQETAV

Show »

Length:929

Mass (Da):104,109

Checksum:ⁱ362346DD9046B323

GO

Isoform 5 (identifier: Q13574-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ
     1046-1046: N → NPCSPS

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        10         20         30         40         50
MEPRDGSPEA RSSDSESASA SSSGSERDAG PEPDKAPRRL NKRRFPGLRL 
        60         70         80         90        100
FGHRKAITKS GLQHLAPPPP TPGAPCSESE RQIRSTVDWS ESATYGEHIW 
       110        120        130        140        150
FETNVSGDFC YVGEQYCVAR MLQKSVSRRK CAACKIVVHT PCIEQLEKIN 
       160        170        180        190        200
FRCKPSFRES GSRNVREPTF VRHHWVHRRR QDGKCRHCGK GFQQKFTFHS 
       210        220        230        240        250
KEIVAISCSW CKQAYHSKVS CFMLQQIEEP CSLGVHAAVV IPPTWILRAR 
       260        270        280        290        300
RPQNTLKASK KKKRASFKRK SSKKGPEEGR WRPFIIRPTP SPLMKPLLVF 
       310        320        330        340        350
VNPKSGGNQG AKIIQSFLWY LNPRQVFDLS QGGPKEALEM YRKVHNLRIL 
       360        370        380        390        400
ACGGDGTVGW ILSTLDQLRL KPPPPVAILP LGTGNDLART LNWGGGYTDE 
       410        420        430        440        450
PVSKILSHVE EGNVVQLDRW DLHAEPNPEA GPEDRDEGAT DRLPLDVFNN 
       460        470        480        490        500
YFSLGFDAHV TLEFHESREA NPEKFNSRFR NKMFYAGTAF SDFLMGSSKD 
       510        520        530        540        550
LAKHIRVVCD GMDLTPKIQD LKPQCVVFLN IPRYCAGTMP WGHPGEHHDF 
       560        570        580        590        600
EPQRHDDGYL EVIGFTMTSL AALQVGGHGE RLTQCREVVL TTSKAIPVQV 
       610        620        630        640        650
DGEPCKLAAS RIRIALRNQA TMVQKAKRRS AAPLHSDQQP VPEQLRIQVS 
       660        670        680        690        700
RVSMHDYEAL HYDKEQLKEA SVPLGTVVVP GDSDLELCRA HIERLQQEPD 
       710        720        730        740        750
GAGAKSPTCQ KLSPKWCFLD ATTASRFYRI DRAQEHLNYV TEIAQDEIYI 
       760        770        780        790        800
LDPELLGASA RPDLPTPTSP LPTSPCSPTP RSLQGDAAPP QGEELIEAAK 
       810        820        830        840        850
RNDFCKLQEL HRAGGDLMHR DEQSRTLLHH AVSTGSKDVV RYLLDHAPPE 
       860        870        880        890        900
ILDAVEENPC SPSGETCLHQ AAALGQRTIC HYIVEAGASL MKTDQQGDTP 
       910        920        930 
RQRAEKAQDT ELAAYLENRQ HYQMIQREDQ ETAV

Show »

Length:934

Mass (Da):104,581

Checksum:ⁱ3B9CEB5C58B865F7

GO

Isoform 6 (identifier: Q13574-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ
     356-378: Missing.

« Hide

        10         20         30         40         50
MEPRDGSPEA RSSDSESASA SSSGSERDAG PEPDKAPRRL NKRRFPGLRL 
        60         70         80         90        100
FGHRKAITKS GLQHLAPPPP TPGAPCSESE RQIRSTVDWS ESATYGEHIW 
       110        120        130        140        150
FETNVSGDFC YVGEQYCVAR MLQKSVSRRK CAACKIVVHT PCIEQLEKIN 
       160        170        180        190        200
FRCKPSFRES GSRNVREGFQ QKFTFHSKEI VAISCSWCKQ AYHSKVSCFM 
       210        220        230        240        250
LQQIEEPCSL GVHAAVVIPP TWILRARRPQ NTLKASKKKK RASFKRKSSK 
       260        270        280        290        300
KGPEEGRWRP FIIRPTPSPL MKPLLVFVNP KSGGNQGAKI IQSFLWYLNP 
       310        320        330        340        350
RQVFDLSQGG PKEALEMYRK VHNLRILACG GDGTVGWILS TLDQLRLKPP 
       360        370        380        390        400
PPVAILPLGT GNDLARTLNW GGGYTDEPVS KILSHVEEGN VVQLDRWDLH 
       410        420        430        440        450
AEPNPEAGPE DRDEGATDRL PLDVFNNYFS LGFDAHVTLE FHESREANPE 
       460        470        480        490        500
KFNSRFRNKM FYAGTAFSDF LMGSSKDLAK HIRVVCDGMD LTPKIQDLKP 
       510        520        530        540        550
QCVVFLNIPR YCAGTMPWGH PGEHHDFEPQ RHDDGYLEVI GFTMTSLAAL 
       560        570        580        590        600
QVGGHGERLT QCREVVLTTS KAIPVQVDGE PCKLAASRIR IALRNQATMV 
       610        620        630        640        650
QKAKRRSAAP LHSDQQPVPE QLRIQVSRVS MHDYEALHYD KEQLKEASVP 
       660        670        680        690        700
LGTVVVPGDS DLELCRAHIE RLQQEPDGAG AKSPTCQKLS PKWCFLDATT 
       710        720        730        740        750
ASRFYRIDRA QEHLNYVTEI AQDEIYILDP ELLGASARPD LPTPTSPLPT 
       760        770        780        790        800
SPCSPTPRSL QGDAAPPQGE ELIEAAKRND FCKLQELHRA GGDLMHRDEQ 
       810        820        830        840        850
SRTLLHHAVS TGSKDVVRYL LDHAPPEILD AVEENGETCL HQAAALGQRT 
       860        870        880        890        900
ICHYIVEAGA SLMKTDQQGD TPRQRAEKAQ DTELAAYLEN RQHYQMIQRE 

DQETAV

Show »

Length:906

Mass (Da):101,230

Checksum:ⁱ99789AD08DCCB5BD

GO

Isoform 7 (identifier: Q13574-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MSAPGAGHSA...QIPSEAPQTQ
     280-280: Missing.
     311-311: L → LQ

« Hide

        10         20         30         40         50
MSAPGAGHSA GGSCNESSAL GPVEALGTEE GERPGSLRQM WRYRSWDVPQ 
        60         70         80         90        100
IPSEAPQTQK AITKSGLQHL APPPPTPGAP CSESERQIRS TVDWSSATYG 
       110        120        130        140        150
EHIWFETNVS GDFCYVGEQY CVARMLQKSV SRRKCAACKI VVHTPCIEQL 
       160        170        180        190        200
EKINFRCKPS FRESGSRNVR EPTFVRHHWV HRRRQDGKCR HCGKGFQQKF 
       210        220        230        240        250
TFHSKEIVAI SCSWCKQAYH SKVSCFMLQQ IEEPCSLGVH AAVVIPPTWI 
       260        270        280        290        300
LRARRPQNTL KASKKKKRAS FKRKSSKKGP EEGRWRPFII RPTPSPLMKP 
       310        320        330        340        350
LLVFVNPKSG GNQGAKIIQS FLWYLNPRQV FDLSQGGPKE ALEMYRKVHN 
       360        370        380        390        400
LRILACGGDG TVGWILSTLD QLRLKPPPPV AILPLGTGND LARTLNWGGG 
       410        420        430        440        450
YTDEPVSKIL SHVEEGNVVQ LDRWDLHAEP NPEAGPEDRD EGATDRLPLD 
       460        470        480        490        500
VFNNYFSLGF DAHVTLEFHE SREANPEKFN SRFRNKMFYA GTAFSDFLMG 
       510        520        530        540        550
SSKDLAKHIR VVCDGMDLTP KIQDLKPQCV VFLNIPRYCA GTMPWGHPGE 
       560        570        580        590        600
HHDFEPQRHD DGYLEVIGFT MTSLAALQVG GHGERLTQCR EVVLTTSKAI 
       610        620        630        640        650
PVQVDGEPCK LAASRIRIAL RNQATMVQKA KRRSAAPLHS DQQPVPEQLR 
       660        670        680        690        700
IQVSRVSMHD YEALHYDKEQ LKEASVPLGT VVVPGDSDLE LCRAHIERLQ 
       710        720        730        740        750
QEPDGAGAKS PTCQKLSPKW CFLDATTASR FYRIDRAQEH LNYVTEIAQD 
       760        770        780        790        800
EIYILDPELL GASARPDLPT PTSPLPTSPC SPTPRSLQGD AAPPQGEELI 
       810        820        830        840        850
EAAKRNDFCK LQELHRAGGD LMHRDEQSRT LLHHAVSTGS KDVVRYLLDH 
       860        870        880        890        900
APPEILDAVE ENGETCLHQA AALGQRTICH YIVEAGASLM KTDQQGDTPR 
       910        920        930 
QRAEKAQDTE LAAYLENRQH YQMIQREDQE TAV

Show »

Length:933

Mass (Da):104,296

Checksum:ⁱ57D46241E25FC58C

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PNL8	E9PNL8_HUMAN	Diacylglycerol kinase Diacylglycerol kinase, DAG kinase, EC 2.7.1.107	DGKZ	707	Annotation score:
E9PNZ3	E9PNZ3_HUMAN	Diacylglycerol kinase zeta Diacylglycerol kinase zeta	DGKZ	135	Annotation score:
E9PK94	E9PK94_HUMAN	Diacylglycerol kinase zeta Diacylglycerol kinase zeta	DGKZ	54	Annotation score:
H0YDN6	H0YDN6_HUMAN	Diacylglycerol kinase zeta Diacylglycerol kinase zeta	DGKZ	197	Annotation score:
H0YEG2	H0YEG2_HUMAN	Diacylglycerol kinase zeta Diacylglycerol kinase zeta	DGKZ	98	Annotation score:
E9PKT3	E9PKT3_HUMAN	Diacylglycerol kinase zeta Diacylglycerol kinase zeta	DGKZ	16	Annotation score:

Sequence cautionⁱ

The sequence AAB60859 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	159	L → V in AAB60859 (PubMed:9159104).Curated	1
Sequence conflictⁱ	494	G → W in BAH11915 (PubMed:14702039).Curated	1
Sequence conflictⁱ	783	A → S in BAH11915 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047371	21	Q → R1 PublicationCorresponds to variant dbSNP:rs1317826Ensembl.	1
Natural variantⁱVAR_061131	69	G → C. Corresponds to variant dbSNP:rs901998Ensembl.	1
Natural variantⁱVAR_069059	712	Q → K1 PublicationCorresponds to variant dbSNP:rs17854149Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_001268	1 – 243	METFF…SALLA → MEPRDGSPEARSSDSESASA SSSGSERDAGPEPDKAPRRL NKRRFPGLRLFGHR in isoform 2, isoform 4, isoform 5 and isoform 6. 4 PublicationsAdd BLAST	243
Alternative sequenceⁱVSP_055147	1 – 243	METFF…SALLA → MSAPGAGHSAGGSCNESSAL GPVEALGTEEGERPGSLRQM WRYRSWDVPQIPSEAPQTQ in isoform 7. CuratedAdd BLAST	243
Alternative sequenceⁱVSP_043163	1 – 71	METFF…AQGSS → MAEGQGGGGQRWDWAGGGRA AEEEVVRRRCRRGEEAQVAQ PWPEGSRGTAAGPPVEERFR QLHLRKQVSYR in isoform 3. 1 PublicationAdd BLAST	71
Alternative sequenceⁱVSP_043164	72 – 243	Missing in isoform 3. 1 PublicationAdd BLAST	172
Alternative sequenceⁱVSP_055148	280	Missing in isoform 7. Curated	1
Alternative sequenceⁱVSP_045628	311	L → LQ in isoform 4, isoform 5, isoform 6 and isoform 7. 3 Publications	1
Alternative sequenceⁱVSP_046919	356 – 378	Missing in isoform 6. 1 PublicationAdd BLAST	23
Alternative sequenceⁱVSP_046920	1046	N → NPCSPS in isoform 5. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U51477 mRNA Translation: AAC50478.1 U94905 mRNA Translation: AAB60859.1 Frameshift. AK124594 mRNA Translation: BAC85894.1 AK294888 mRNA Translation: BAH11915.1 AK300577 mRNA Translation: BAH13309.1 AK225774 mRNA No translation available. AC116021 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68008.1 BC041770 mRNA Translation: AAH41770.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41640.1 [Q13574-1] CCDS44579.2 [Q13574-7] CCDS44580.1 [Q13574-4] CCDS55757.1 [Q13574-5] CCDS55758.1 [Q13574-6] CCDS55759.1 [Q13574-2] CCDS7918.1 [Q13574-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001099010.1, NM_001105540.1 [Q13574-1] NP_001186195.1, NM_001199266.1 [Q13574-5] NP_001186196.1, NM_001199267.1 [Q13574-2] NP_001186197.1, NM_001199268.1 [Q13574-6] NP_003637.2, NM_003646.3 [Q13574-4] NP_963290.1, NM_201532.2 [Q13574-3] NP_963291.2, NM_201533.3 [Q13574-7]

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13574-7	Diacylglycerol kinase		PANPA		933	UniRef100_A0A2R9BXR0

Protein	Similar proteins		Species	Score	Length	Source
Q13574-2	Diacylglycerol kinase		PANTR		928	UniRef90_Q13574-2
Q13574-4	Diacylglycerol kinase		RHIBE		929	UniRef90_Q13574-4
Diacylglycerol kinase		RHIRO		929
Diacylglycerol kinase		PANTR		929
Diacylglycerol kinase		MACFA		929
Diacylglycerol kinase		MESAU		928
+5
Q13574-5	Diacylglycerol kinase		PANTR		934	UniRef90_Q13574-5
Q13574-6	Diacylglycerol kinase		PANTR		906	UniRef90_Q13574-6
Q13574-7	Diacylglycerol kinase		PANTR		933	UniRef90_A0A2I3RU01
Diacylglycerol kinase		PANPA		933

Protein	Similar proteins		Species	Score	Length	Source
Q13574	Diacylglycerol kinase zeta		RAT		929	UniRef50_Q13574
Diacylglycerol kinase		ICTTR		1154
Diacylglycerol kinase		MARMO		928
Diacylglycerol kinase		COLAP		925
Diacylglycerol kinase		PTEAL		1157
+624
Q13574-2	Isoform 3 of Diacylglycerol kinase zeta		HUMAN		945	UniRef50_Q13574-3
Diacylglycerol kinase zeta		MOUSE		929
Diacylglycerol kinase		DELLE		928
Diacylglycerol kinase		Agassiz's desert tortoise		865
Diacylglycerol kinase		PIG		910
+292
Q13574-6	Diacylglycerol kinase		PANTR		906	UniRef50_Q13574-6
Diacylglycerol kinase		PONAB		906
Diacylglycerol kinase		LATCA		948
Diacylglycerol kinase		ODORO		906
Diacylglycerol kinase		AOTNA		906
+25
Q13574-7	Diacylglycerol kinase		ANOCA		1031	UniRef50_G1KCV4
Diacylglycerol kinase		HORSE		934
Diacylglycerol kinase		URSMA		845
Diacylglycerol kinase		ODORO		945
Diacylglycerol kinase		Ursus arctos horribilis		929
+290

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U51477 mRNA Translation: AAC50478.1 U94905 mRNA Translation: AAB60859.1 Frameshift. AK124594 mRNA Translation: BAC85894.1 AK294888 mRNA Translation: BAH11915.1 AK300577 mRNA Translation: BAH13309.1 AK225774 mRNA No translation available. AC116021 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68008.1 BC041770 mRNA Translation: AAH41770.1
CCDSⁱ	CCDS41640.1 [Q13574-1] CCDS44579.2 [Q13574-7] CCDS44580.1 [Q13574-4] CCDS55757.1 [Q13574-5] CCDS55758.1 [Q13574-6] CCDS55759.1 [Q13574-2] CCDS7918.1 [Q13574-3]
RefSeqⁱ	NP_001099010.1, NM_001105540.1 [Q13574-1] NP_001186195.1, NM_001199266.1 [Q13574-5] NP_001186196.1, NM_001199267.1 [Q13574-2] NP_001186197.1, NM_001199268.1 [Q13574-6] NP_003637.2, NM_003646.3 [Q13574-4] NP_963290.1, NM_201532.2 [Q13574-3] NP_963291.2, NM_201533.3 [Q13574-7]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5ELQ	X-ray	1.10	C/P	1110-1117	[»]
SMRⁱ	Q13574
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114095, 70 interactors
CORUMⁱ	Q13574
IntActⁱ	Q13574, 16 interactors
MINTⁱ	Q13574
STRINGⁱ	9606.ENSP00000412178

Chemistry databases

ChEMBLⁱ	CHEMBL4105942
SwissLipidsⁱ	SLP:000000547 SLP:000000921 [Q13574-1] SLP:000000922 [Q13574-2]

PTM databases

iPTMnetⁱ	Q13574
PhosphoSitePlusⁱ	Q13574

Polymorphism and mutation databases

BioMutaⁱ	DGKZ
DMDMⁱ	215274170

Proteomic databases

EPDⁱ	Q13574
jPOSTⁱ	Q13574
MassIVEⁱ	Q13574
MaxQBⁱ	Q13574
PaxDbⁱ	Q13574
PeptideAtlasⁱ	Q13574
PRIDEⁱ	Q13574
ProteomicsDBⁱ	22840 32183 59578 [Q13574-1] 59579 [Q13574-2] 59580 [Q13574-3] 6789

Genome annotation databases

Ensemblⁱ	ENST00000318201; ENSP00000320340; ENSG00000149091 [Q13574-6] ENST00000343674; ENSP00000343065; ENSG00000149091 [Q13574-3] ENST00000421244; ENSP00000391021; ENSG00000149091 [Q13574-4] ENST00000454345; ENSP00000412178; ENSG00000149091 [Q13574-1] ENST00000456247; ENSP00000395684; ENSG00000149091 [Q13574-2] ENST00000527911; ENSP00000436291; ENSG00000149091 [Q13574-5] ENST00000532868; ENSP00000436273; ENSG00000149091 [Q13574-7]
GeneIDⁱ	8525
KEGGⁱ	hsa:8525
UCSCⁱ	uc001nch.2 human [Q13574-1]

Organism-specific databases

CTDⁱ	8525
DisGeNETⁱ	8525
EuPathDBⁱ	HostDB:ENSG00000149091.15
GeneCardsⁱ	DGKZ
HGNCⁱ	HGNC:2857 DGKZ
HPAⁱ	HPA051336
MIMⁱ	601441 gene
neXtProtⁱ	NX_Q13574
OpenTargetsⁱ	ENSG00000149091
PharmGKBⁱ	PA27318
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0782 Eukaryota ENOG410XSCB LUCA
GeneTreeⁱ	ENSGT00940000156152
HOGENOMⁱ	HOG000231472
InParanoidⁱ	Q13574
KOⁱ	K00901
OMAⁱ	LQHMVAQ
OrthoDBⁱ	274339at2759
PhylomeDBⁱ	Q13574
TreeFamⁱ	TF312817

Enzyme and pathway databases

BRENDAⁱ	2.7.1.107 2681
Reactomeⁱ	R-HSA-114508 Effects of PIP2 hydrolysis
SIGNORⁱ	Q13574

Miscellaneous databases

ChiTaRSⁱ	DGKZ human
GeneWikiⁱ	DGKZ
GenomeRNAiⁱ	8525
Pharosⁱ	Q13574 Tbio
Protein Ontology More...PROⁱ	PR:Q13574
RNActⁱ	Q13574 protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149091 Expressed in 102 organ(s), highest expression level in right frontal lobe
ExpressionAtlasⁱ	Q13574 baseline and differential
Genevisibleⁱ	Q13574 HS

Family and domain databases

CDDⁱ	cd00029 C1, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit 3.40.50.10330, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR017438 ATP-NAD_kinase_N IPR037607 DGK IPR000756 Diacylglycerol_kin_accessory IPR001206 Diacylglycerol_kinase_cat_dom IPR016064 NAD/diacylglycerol_kinase_sf IPR002219 PE/DAG-bd
PANTHERⁱ	PTHR11255 PTHR11255, 1 hit
Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF00130 C1_1, 1 hit PF00609 DAGK_acc, 1 hit PF00781 DAGK_cat, 1 hit
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits SM00109 C1, 2 hits SM00045 DAGKa, 1 hit SM00046 DAGKc, 1 hit
SUPFAMⁱ	SSF111331 SSF111331, 1 hit SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits PS50146 DAGK, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DGKZ_HUMAN
Accessionⁱ	Q13574Primary (citable) accession number: Q13574 Secondary accession number(s): B7Z2M9 Q8IVW9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 25, 2008
	Last modified:	December 11, 2019
	This is version 197 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - Q13574 (DGKZ_HUMAN)

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Diacylglycerol kinase zeta

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

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Nucleus

Plasma Membrane

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Organism-specific databases

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Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

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Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Polymorphism and mutation databases

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ