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UniProtKB - Q13574 (DGKZ_HUMAN)

Entry version 205 (07 Apr 2021)
Sequence version 4 (17 Jun 2020)
Previous versions | rss
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Protein

Diacylglycerol kinase zeta

Gene

DGKZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity).By similarity1 Publication8 Publications
Regulates RASGRP1 activity.1 Publication
Does not regulate RASGRP1 activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by 1,2-diacyl-sn-glycero-3-phosphate/phosphatidic acid irrespective of its acyl chain composition.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerolipid metabolism

This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri98 – 152Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST55
Zinc fingeri172 – 230Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST59

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.107, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13574

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114508, Effects of PIP2 hydrolysis

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13574

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00230

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000547
SLP:000000921 [Q13574-1]
SLP:000000922 [Q13574-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol kinase zeta1 Publication (EC:2.7.1.1077 Publications)
Short name:
DAG kinase zeta
Alternative name(s):
Diglyceride kinase zeta
Short name:
DGK-zeta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DGKZImported
Synonyms:DAGK6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2857, DGKZ

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601441, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13574

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000149091.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi926 – 927TA → NS: Loss of interaction with SNTG1. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		8525

Open Targets

More...OpenTargetsi		ENSG00000149091

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27318

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13574, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105942

Drug and drug target database

More...DrugBanki		DB14001, alpha-Tocopherol succinate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DGKZ

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274170

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002184681 – 928Diacylglycerol kinase zetaAdd BLAST928

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei705PhosphoserineCombined sources1
Modified residuei781PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13574

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13574

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13574

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13574

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13574

PeptideAtlas

More...PeptideAtlasi		Q13574

PRoteomics IDEntifications database

More...PRIDEi		Q13574

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		22840
32183
59578 [Q13574-1]
59579 [Q13574-2]
59580 [Q13574-3]
6789

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13574

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q13574

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13574

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas.1 Publication
Predominantly expressed in muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000149091, Expressed in right frontal lobe and 124 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13574, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13574, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000149091, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PDZ-binding motif) with the PDZ domain of the syntrophin SNTG1 and that of SNX27 (PubMed:11352924, PubMed:17351151).

Interacts with IRS1 in the absence of insulin; insulin stimulation decreases this interaction (By similarity).

Found in a ternary complex with IRS1 and PIP5K1A in the absence of insulin (By similarity).

Interacts with PIP5K1A (PubMed:15157668).

By similarity3 Publications

Forms a signaling complex with RASGRP1 and HRAS.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114095, 76 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q13574

Protein interaction database and analysis system

More...IntActi		Q13574, 16 interactors

Molecular INTeraction database

More...MINTi		Q13574

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000412178

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q13574

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13574, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1928
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13574

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini291 – 425DAGKcPROSITE-ProRule annotationAdd BLAST135
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati822 – 852ANK 1Sequence analysisAdd BLAST31
Repeati857 – 886ANK 2Sequence analysisAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni259 – 273MARCKS homologyAdd BLAST15
Regioni278 – 416Mediates interaction with RASGRP11 PublicationAdd BLAST139

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi361 – 369Nuclear export signalBy similarity9
Motifi924 – 928PDZ-binding2 Publications5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ-binding motif mediates interaction with PDZ domain-containing proteins like SNTG1 and SNX27.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri98 – 152Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST55
Zinc fingeri172 – 230Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0782, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156152

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13574

Identification of Orthologs from Complete Genome Data

More...OMAi		GEPCKLT

Database of Orthologous Groups

More...OrthoDBi		274339at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13574

TreeFam database of animal gene trees

More...TreeFami		TF312817

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029, C1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit
3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR017438, ATP-NAD_kinase_N
IPR037607, DGK
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd

The PANTHER Classification System

More...PANTHERi		PTHR11255, PTHR11255, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 1 hit
PF00130, C1_1, 1 hit
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 2 hits
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111331, SSF111331, 1 hit
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50146, DAGK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13574-2) [UniParc]FASTAAdd to basket
Also known as: Short

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRDGSPEA RSSDSESASA SSSGSERDAG PEPDKAPRRL NKRRFPGLRL 
        60         70         80         90        100
FGHRKAITKS GLQHLAPPPP TPGAPCSESE RQIRSTVDWS ESATYGEHIW 
       110        120        130        140        150
FETNVSGDFC YVGEQYCVAR MLKSVSRRKC AACKIVVHTP CIEQLEKINF 
       160        170        180        190        200
RCKPSFRESG SRNVREPTFV RHHWVHRRRQ DGKCRHCGKG FQQKFTFHSK 
       210        220        230        240        250
EIVAISCSWC KQAYHSKVSC FMLQQIEEPC SLGVHAAVVI PPTWILRARR 
       260        270        280        290        300
PQNTLKASKK KKRASFKRKS SKKGPEEGRW RPFIIRPTPS PLMKPLLVFV 
       310        320        330        340        350
NPKSGGNQGA KIIQSFLWYL NPRQVFDLSQ GGPKEALEMY RKVHNLRILA 
       360        370        380        390        400
CGGDGTVGWI LSTLDQLRLK PPPPVAILPL GTGNDLARTL NWGGGYTDEP 
       410        420        430        440        450
VSKILSHVEE GNVVQLDRWD LHAEPNPEAG PEDRDEGATD RLPLDVFNNY 
       460        470        480        490        500
FSLGFDAHVT LEFHESREAN PEKFNSRFRN KMFYAGTAFS DFLMGSSKDL 
       510        520        530        540        550
AKHIRVVCDG MDLTPKIQDL KPQCVVFLNI PRYCAGTMPW GHPGEHHDFE 
       560        570        580        590        600
PQRHDDGYLE VIGFTMTSLA ALQVGGHGER LTQCREVVLT TSKAIPVQVD 
       610        620        630        640        650
GEPCKLAASR IRIALRNQAT MVQKAKRRSA APLHSDQQPV PEQLRIQVSR 
       660        670        680        690        700
VSMHDYEALH YDKEQLKEAS VPLGTVVVPG DSDLELCRAH IERLQQEPDG 
       710        720        730        740        750
AGAKSPTCQK LSPKWCFLDA TTASRFYRID RAQEHLNYVT EIAQDEIYIL 
       760        770        780        790        800
DPELLGASAR PDLPTPTSPL PTSPCSPTPR SLQGDAAPPQ GEELIEAAKR 
       810        820        830        840        850
NDFCKLQELH RAGGDLMHRD EQSRTLLHHA VSTGSKDVVR YLLDHAPPEI 
       860        870        880        890        900
LDAVEENGET CLHQAAALGQ RTICHYIVEA GASLMKTDQQ GDTPRQRAEK 
       910        920 
AQDTELAAYL ENRQHYQMIQ REDQETAV
Note: Major isoform.Curated
Length:928
Mass (Da):103,981
Last modified:June 17, 2020 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7936A979CB3D35AA
GO
Isoform 2 (identifier: Q13574-1) [UniParc]FASTAAdd to basket
Also known as: Long, zeta2

The sequence of this isoform differs from the canonical sequence as follows:
     3-54: PRDGSPEARS...FPGLRLFGHR → TFFRRHFRGK...GPQAWSALLA

Note: Minor isoform.
Show »
Length:1,117
Mass (Da):124,128
Checksum:iF3A7C2382ECF549B
GO
Isoform 3 (identifier: Q13574-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MEPRDGSPEA...RFPGLRLFGH → MAEGQGGGGQ...QLHLRKQVSY

Show »
Length:945
Mass (Da):106,030
Checksum:i6EF612B9FE91F7E7
GO
Isoform 4 (identifier: Q13574-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-122: L → LQ

Show »
Length:929
Mass (Da):104,109
Checksum:i362346DD9046B323
GO
Isoform 5 (identifier: Q13574-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-122: L → LQ
     857-857: N → NPCSPS

Show »
Length:934
Mass (Da):104,581
Checksum:i3B9CEB5C58B865F7
GO
Isoform 6 (identifier: Q13574-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-122: L → LQ
     167-189: Missing.

Show »
Length:906
Mass (Da):101,230
Checksum:i99789AD08DCCB5BD
GO
Isoform 7 (identifier: Q13574-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: MEPRDGSPEA...FPGLRLFGHR → MSAPGAGHSA...QIPSEAPQTQ
     91-91: Missing.
     122-122: L → LQ

Show »
Length:933
Mass (Da):104,296
Checksum:i57D46241E25FC58C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNL8E9PNL8_HUMAN
Diacylglycerol kinase
DGKZ
707Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNZ3E9PNZ3_HUMAN
Diacylglycerol kinase zeta
DGKZ
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDN6H0YDN6_HUMAN
Diacylglycerol kinase zeta
DGKZ
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEG2H0YEG2_HUMAN
Diacylglycerol kinase zeta
DGKZ
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK94E9PK94_HUMAN
Diacylglycerol kinase zeta
DGKZ
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKT3E9PKT3_HUMAN
Diacylglycerol kinase zeta
DGKZ
16Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB60859 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti305G → W in BAH11915 (PubMed:14702039).Curated1
Sequence conflicti594A → S in BAH11915 (PubMed:14702039).Curated1
Isoform 2 (identifier: Q13574-1)
Sequence conflicti159L → V in AAB60859 (PubMed:9159104).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069059523Q → K1 PublicationCorresponds to variant dbSNP:rs17854149Ensembl.1
Isoform 2 (identifier: Q13574-1)
Natural variantiVAR_08355221Q → R1 PublicationCorresponds to variant dbSNP:rs1317826Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0605971 – 54MEPRD…LFGHR → MSAPGAGHSAGGSCNESSAL GPVEALGTEEGERPGSLRQM WRYRSWDVPQIPSEAPQTQ in isoform 7. Add BLAST54
Alternative sequenceiVSP_0605981 – 53MEPRD…RLFGH → MAEGQGGGGQRWDWAGGGRA AEEEVVRRRCRRGEEAQVAQ PWPEGSRGTAAGPPVEERFR QLHLRKQVSY in isoform 3. Add BLAST53
Alternative sequenceiVSP_0605993 – 54PRDGS…LFGHR → TFFRRHFRGKVPGPGEGQQR PSSVGLPTGKARRRSPAGQA SSSLAQRRRSSAQLQGCLLS CGVRAQGSSRRRSSTVPPSC NPRFIVDKVLTPQPTTVGAQ LLGAPLLLTGLVGMNEEEGV QEDVVAEASSAIQPGTKTPG PPPPRGAQPLLPLPRYLRRA SSHLLPADAVYDHALWGLHG YYRRLSQRRPSGQHPGPGGR RASGTTAGTMLPTRVRPLSR RRQVALRRKAAGPQAWSALL A in isoform 2. Add BLAST52
Alternative sequenceiVSP_06060091Missing in isoform 7. 1
Alternative sequenceiVSP_060601122L → LQ in isoform 6, isoform 7, isoform 5 and isoform 4. 1
Alternative sequenceiVSP_060602167 – 189Missing in isoform 6. Add BLAST23
Alternative sequenceiVSP_060603857N → NPCSPS in isoform 5. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U51477 mRNA Translation: AAC50478.1
U94905 mRNA Translation: AAB60859.1 Frameshift.
AK124594 mRNA Translation: BAC85894.1
AK294888 mRNA Translation: BAH11915.1
AK300577 mRNA Translation: BAH13309.1
AK225774 mRNA No translation available.
AC116021 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68008.1
BC041770 mRNA Translation: AAH41770.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41640.1 [Q13574-1]
CCDS44579.2 [Q13574-7]
CCDS44580.1 [Q13574-4]
CCDS55757.1 [Q13574-5]
CCDS55758.1 [Q13574-6]
CCDS55759.1 [Q13574-2]
CCDS7918.1 [Q13574-3]

NCBI Reference Sequences

More...RefSeqi		NP_001099010.1, NM_001105540.1 [Q13574-1]
NP_001186195.1, NM_001199266.1 [Q13574-5]
NP_001186196.1, NM_001199267.1 [Q13574-2]
NP_001186197.1, NM_001199268.1 [Q13574-6]
NP_003637.2, NM_003646.3 [Q13574-4]
NP_963290.1, NM_201532.2 [Q13574-3]
NP_963291.2, NM_201533.3 [Q13574-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000318201; ENSP00000320340; ENSG00000149091 [Q13574-6]
ENST00000343674; ENSP00000343065; ENSG00000149091 [Q13574-3]
ENST00000421244; ENSP00000391021; ENSG00000149091 [Q13574-4]
ENST00000454345; ENSP00000412178; ENSG00000149091 [Q13574-1]
ENST00000456247; ENSP00000395684; ENSG00000149091 [Q13574-2]
ENST00000527911; ENSP00000436291; ENSG00000149091 [Q13574-5]
ENST00000532868; ENSP00000436273; ENSG00000149091 [Q13574-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8525

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8525

UCSC genome browser

More...UCSCi		uc001nch.2, human [Q13574-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51477 mRNA Translation: AAC50478.1
U94905 mRNA Translation: AAB60859.1 Frameshift.
AK124594 mRNA Translation: BAC85894.1
AK294888 mRNA Translation: BAH11915.1
AK300577 mRNA Translation: BAH13309.1
AK225774 mRNA No translation available.
AC116021 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68008.1
BC041770 mRNA Translation: AAH41770.1
CCDSiCCDS41640.1 [Q13574-1]
CCDS44579.2 [Q13574-7]
CCDS44580.1 [Q13574-4]
CCDS55757.1 [Q13574-5]
CCDS55758.1 [Q13574-6]
CCDS55759.1 [Q13574-2]
CCDS7918.1 [Q13574-3]
RefSeqiNP_001099010.1, NM_001105540.1 [Q13574-1]
NP_001186195.1, NM_001199266.1 [Q13574-5]
NP_001186196.1, NM_001199267.1 [Q13574-2]
NP_001186197.1, NM_001199268.1 [Q13574-6]
NP_003637.2, NM_003646.3 [Q13574-4]
NP_963290.1, NM_201532.2 [Q13574-3]
NP_963291.2, NM_201533.3 [Q13574-7]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ELQX-ray1.10C/P921-928[»]
SMRiQ13574
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114095, 76 interactors
CORUMiQ13574
IntActiQ13574, 16 interactors
MINTiQ13574
STRINGi9606.ENSP00000412178

Chemistry databases

BindingDBiQ13574
ChEMBLiCHEMBL4105942
DrugBankiDB14001, alpha-Tocopherol succinate
SwissLipidsiSLP:000000547
SLP:000000921 [Q13574-1]
SLP:000000922 [Q13574-2]

PTM databases

iPTMnetiQ13574
MetOSiteiQ13574
PhosphoSitePlusiQ13574

Genetic variation databases

BioMutaiDGKZ
DMDMi215274170

Proteomic databases

EPDiQ13574
jPOSTiQ13574
MassIVEiQ13574
MaxQBiQ13574
PaxDbiQ13574
PeptideAtlasiQ13574
PRIDEiQ13574
ProteomicsDBi22840
32183
59578 [Q13574-1]
59579 [Q13574-2]
59580 [Q13574-3]
6789

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26268, 231 antibodies

Genome annotation databases

EnsembliENST00000318201; ENSP00000320340; ENSG00000149091 [Q13574-6]
ENST00000343674; ENSP00000343065; ENSG00000149091 [Q13574-3]
ENST00000421244; ENSP00000391021; ENSG00000149091 [Q13574-4]
ENST00000454345; ENSP00000412178; ENSG00000149091 [Q13574-1]
ENST00000456247; ENSP00000395684; ENSG00000149091 [Q13574-2]
ENST00000527911; ENSP00000436291; ENSG00000149091 [Q13574-5]
ENST00000532868; ENSP00000436273; ENSG00000149091 [Q13574-7]
GeneIDi8525
KEGGihsa:8525
UCSCiuc001nch.2, human [Q13574-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8525
DisGeNETi8525

GeneCards: human genes, protein and diseases

More...GeneCardsi		DGKZ
HGNCiHGNC:2857, DGKZ
HPAiENSG00000149091, Tissue enhanced (brain)
MIMi601441, gene
neXtProtiNX_Q13574
OpenTargetsiENSG00000149091
PharmGKBiPA27318
VEuPathDBiHostDB:ENSG00000149091.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0782, Eukaryota
GeneTreeiENSGT00940000156152
InParanoidiQ13574
OMAiGEPCKLT
OrthoDBi274339at2759
PhylomeDBiQ13574
TreeFamiTF312817

Enzyme and pathway databases

UniPathwayiUPA00230
BRENDAi2.7.1.107, 2681
PathwayCommonsiQ13574
ReactomeiR-HSA-114508, Effects of PIP2 hydrolysis
SIGNORiQ13574

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8525, 9 hits in 998 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DGKZ, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DGKZ

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8525
PharosiQ13574, Tbio

Protein Ontology

More...PROi		PR:Q13574
RNActiQ13574, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000149091, Expressed in right frontal lobe and 124 other tissues
ExpressionAtlasiQ13574, baseline and differential
GenevisibleiQ13574, HS

Family and domain databases

CDDicd00029, C1, 1 hit
Gene3Di1.25.40.20, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR017438, ATP-NAD_kinase_N
IPR037607, DGK
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd
PANTHERiPTHR11255, PTHR11255, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF00130, C1_1, 1 hit
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SUPFAMiSSF111331, SSF111331, 1 hit
SSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50146, DAGK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGKZ_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13574
Secondary accession number(s): B7Z2M9
, B7Z6M3, E9PPW4, F6UCU9, G3V0F6, J3KNJ6, O00542, Q6ZVG7, Q8IVW9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 17, 2020
Last modified: April 7, 2021
This is version 205 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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