UniProtKB - Q13574 (DGKZ_HUMAN)
Diacylglycerol kinase zeta
DGKZ
Functioni
Catalytic activityi
- EC:2.7.1.1078 PublicationsThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- 1,2-ditetradecanoyl-sn-glycerol + ATP = 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H+2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H+6 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+8 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H+2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
Activity regulationi
: glycerolipid metabolism Pathwayi
This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 98 – 152 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 55 | |
Zinc fingeri | 172 – 230 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 59 |
GO - Molecular functioni
- ATP binding Source: ProtInc
- diacylglycerol kinase activity Source: UniProtKB
- kinase activity Source: BHF-UCL
- lipid kinase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- NAD+ kinase activity Source: InterPro
- protein C-terminus binding Source: UniProtKB
GO - Biological processi
- cell migration Source: UniProtKB
- diacylglycerol metabolic process Source: UniProtKB
- glycerolipid metabolic process Source: BHF-UCL
- intracellular signal transduction Source: GO_Central
- lipid phosphorylation Source: UniProtKB
- mitotic G1 DNA damage checkpoint Source: UniProtKB
- negative regulation of mitotic cell cycle Source: UniProtKB
- negative regulation of T cell receptor signaling pathway Source: UniProtKB
- phosphatidic acid biosynthetic process Source: UniProtKB
- platelet activation Source: Reactome
- positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
- regulation of synaptic transmission, glutamatergic Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.1.107, 2681 |
PathwayCommonsi | Q13574 |
Reactomei | R-HSA-114508, Effects of PIP2 hydrolysis |
SIGNORi | Q13574 |
UniPathwayi | UPA00230 |
Chemistry databases
SwissLipidsi | SLP:000000547 SLP:000000921 [Q13574-1] SLP:000000922 [Q13574-2] |
Names & Taxonomyi
Protein namesi | Recommended name: Diacylglycerol kinase zeta1 Publication (EC:2.7.1.1077 Publications)Short name: DAG kinase zeta Alternative name(s): Diglyceride kinase zeta Short name: DGK-zeta |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2857, DGKZ |
MIMi | 601441, gene |
neXtProti | NX_Q13574 |
VEuPathDBi | HostDB:ENSG00000149091.15 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Nucleus
- Nucleus 4 Publications
Cytoplasm and Cytosol
- cytosol 2 Publications
Other locations
- lamellipodium 1 Publication
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nuclear speck Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: BHF-UCL
- glutamatergic synapse Source: Ensembl
- lamellipodium Source: UniProtKB
- postsynaptic density Source: Ensembl
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 926 – 927 | TA → NS: Loss of interaction with SNTG1. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 8525 |
OpenTargetsi | ENSG00000149091 |
PharmGKBi | PA27318 |
Miscellaneous databases
Pharosi | Q13574, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105942 |
DrugBanki | DB14001, alpha-Tocopherol succinate |
Genetic variation databases
BioMutai | DGKZ |
DMDMi | 215274170 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218468 | 1 – 928 | Diacylglycerol kinase zetaAdd BLAST | 928 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 705 | PhosphoserineCombined sources | 1 | |
Modified residuei | 781 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q13574 |
jPOSTi | Q13574 |
MassIVEi | Q13574 |
MaxQBi | Q13574 |
PaxDbi | Q13574 |
PeptideAtlasi | Q13574 |
PRIDEi | Q13574 |
ProteomicsDBi | 22840 32183 59578 [Q13574-1] 59579 [Q13574-2] 59580 [Q13574-3] 6789 |
PTM databases
iPTMneti | Q13574 |
MetOSitei | Q13574 |
PhosphoSitePlusi | Q13574 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000149091, Expressed in right frontal lobe and 124 other tissues |
ExpressionAtlasi | Q13574, baseline and differential |
Genevisiblei | Q13574, HS |
Organism-specific databases
HPAi | ENSG00000149091, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts (via PDZ-binding motif) with the PDZ domain of the syntrophin SNTG1 and that of SNX27 (PubMed:11352924, PubMed:17351151).
Interacts with IRS1 in the absence of insulin; insulin stimulation decreases this interaction (By similarity).
Found in a ternary complex with IRS1 and PIP5K1A in the absence of insulin (By similarity).
Interacts with PIP5K1A (PubMed:15157668).
By similarity3 PublicationsBinary interactionsi
Hide detailsIsoform 1 [Q13574-2]
With | #Exp. | IntAct |
---|---|---|
RB1 [P06400] | 6 | EBI-715527,EBI-491274 |
RBL1 [P28749] | 2 | EBI-715527,EBI-971402 |
RBL2 [Q08999] | 2 | EBI-715527,EBI-971439 |
GO - Molecular functioni
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114095, 76 interactors |
CORUMi | Q13574 |
IntActi | Q13574, 16 interactors |
MINTi | Q13574 |
STRINGi | 9606.ENSP00000412178 |
Chemistry databases
BindingDBi | Q13574 |
Miscellaneous databases
RNActi | Q13574, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13574 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 291 – 425 | DAGKcPROSITE-ProRule annotationAdd BLAST | 135 | |
Repeati | 822 – 852 | ANK 1Sequence analysisAdd BLAST | 31 | |
Repeati | 857 – 886 | ANK 2Sequence analysisAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 259 – 273 | MARCKS homologyAdd BLAST | 15 | |
Regioni | 278 – 416 | Mediates interaction with RASGRP11 PublicationAdd BLAST | 139 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 361 – 369 | Nuclear export signalBy similarity | 9 | |
Motifi | 924 – 928 | PDZ-binding2 Publications | 5 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 98 – 152 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 55 | |
Zinc fingeri | 172 – 230 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 59 |
Keywords - Domaini
ANK repeat, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0782, Eukaryota |
GeneTreei | ENSGT00940000156152 |
InParanoidi | Q13574 |
OMAi | GEPCKLT |
OrthoDBi | 274339at2759 |
PhylomeDBi | Q13574 |
TreeFami | TF312817 |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 1.25.40.20, 1 hit 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR017438, ATP-NAD_kinase_N IPR037607, DGK IPR000756, Diacylglycerol_kin_accessory IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf IPR002219, PE/DAG-bd |
PANTHERi | PTHR11255, PTHR11255, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00130, C1_1, 1 hit PF00609, DAGK_acc, 1 hit PF00781, DAGK_cat, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00109, C1, 2 hits SM00045, DAGKa, 1 hit SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits PS50146, DAGK, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPRDGSPEA RSSDSESASA SSSGSERDAG PEPDKAPRRL NKRRFPGLRL
60 70 80 90 100
FGHRKAITKS GLQHLAPPPP TPGAPCSESE RQIRSTVDWS ESATYGEHIW
110 120 130 140 150
FETNVSGDFC YVGEQYCVAR MLKSVSRRKC AACKIVVHTP CIEQLEKINF
160 170 180 190 200
RCKPSFRESG SRNVREPTFV RHHWVHRRRQ DGKCRHCGKG FQQKFTFHSK
210 220 230 240 250
EIVAISCSWC KQAYHSKVSC FMLQQIEEPC SLGVHAAVVI PPTWILRARR
260 270 280 290 300
PQNTLKASKK KKRASFKRKS SKKGPEEGRW RPFIIRPTPS PLMKPLLVFV
310 320 330 340 350
NPKSGGNQGA KIIQSFLWYL NPRQVFDLSQ GGPKEALEMY RKVHNLRILA
360 370 380 390 400
CGGDGTVGWI LSTLDQLRLK PPPPVAILPL GTGNDLARTL NWGGGYTDEP
410 420 430 440 450
VSKILSHVEE GNVVQLDRWD LHAEPNPEAG PEDRDEGATD RLPLDVFNNY
460 470 480 490 500
FSLGFDAHVT LEFHESREAN PEKFNSRFRN KMFYAGTAFS DFLMGSSKDL
510 520 530 540 550
AKHIRVVCDG MDLTPKIQDL KPQCVVFLNI PRYCAGTMPW GHPGEHHDFE
560 570 580 590 600
PQRHDDGYLE VIGFTMTSLA ALQVGGHGER LTQCREVVLT TSKAIPVQVD
610 620 630 640 650
GEPCKLAASR IRIALRNQAT MVQKAKRRSA APLHSDQQPV PEQLRIQVSR
660 670 680 690 700
VSMHDYEALH YDKEQLKEAS VPLGTVVVPG DSDLELCRAH IERLQQEPDG
710 720 730 740 750
AGAKSPTCQK LSPKWCFLDA TTASRFYRID RAQEHLNYVT EIAQDEIYIL
760 770 780 790 800
DPELLGASAR PDLPTPTSPL PTSPCSPTPR SLQGDAAPPQ GEELIEAAKR
810 820 830 840 850
NDFCKLQELH RAGGDLMHRD EQSRTLLHHA VSTGSKDVVR YLLDHAPPEI
860 870 880 890 900
LDAVEENGET CLHQAAALGQ RTICHYIVEA GASLMKTDQQ GDTPRQRAEK
910 920
AQDTELAAYL ENRQHYQMIQ REDQETAV
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PNL8 | E9PNL8_HUMAN | Diacylglycerol kinase | DGKZ | 707 | Annotation score: | ||
E9PNZ3 | E9PNZ3_HUMAN | Diacylglycerol kinase zeta | DGKZ | 135 | Annotation score: | ||
H0YDN6 | H0YDN6_HUMAN | Diacylglycerol kinase zeta | DGKZ | 197 | Annotation score: | ||
H0YEG2 | H0YEG2_HUMAN | Diacylglycerol kinase zeta | DGKZ | 98 | Annotation score: | ||
E9PK94 | E9PK94_HUMAN | Diacylglycerol kinase zeta | DGKZ | 54 | Annotation score: | ||
E9PKT3 | E9PKT3_HUMAN | Diacylglycerol kinase zeta | DGKZ | 16 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 305 | G → W in BAH11915 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 594 | A → S in BAH11915 (PubMed:14702039).Curated | 1 | ||
Isoform 2 (identifier: Q13574-1) | |||||
Sequence conflicti | 159 | L → V in AAB60859 (PubMed:9159104).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_069059 | 523 | Q → K1 PublicationCorresponds to variant dbSNP:rs17854149Ensembl. | 1 | ||
Isoform 2 (identifier: Q13574-1) | |||||
Natural variantiVAR_083552 | 21 | Q → R1 PublicationCorresponds to variant dbSNP:rs1317826Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060597 | 1 – 54 | MEPRD…LFGHR → MSAPGAGHSAGGSCNESSAL GPVEALGTEEGERPGSLRQM WRYRSWDVPQIPSEAPQTQ in isoform 7. Add BLAST | 54 | |
Alternative sequenceiVSP_060598 | 1 – 53 | MEPRD…RLFGH → MAEGQGGGGQRWDWAGGGRA AEEEVVRRRCRRGEEAQVAQ PWPEGSRGTAAGPPVEERFR QLHLRKQVSY in isoform 3. Add BLAST | 53 | |
Alternative sequenceiVSP_060599 | 3 – 54 | PRDGS…LFGHR → TFFRRHFRGKVPGPGEGQQR PSSVGLPTGKARRRSPAGQA SSSLAQRRRSSAQLQGCLLS CGVRAQGSSRRRSSTVPPSC NPRFIVDKVLTPQPTTVGAQ LLGAPLLLTGLVGMNEEEGV QEDVVAEASSAIQPGTKTPG PPPPRGAQPLLPLPRYLRRA SSHLLPADAVYDHALWGLHG YYRRLSQRRPSGQHPGPGGR RASGTTAGTMLPTRVRPLSR RRQVALRRKAAGPQAWSALL A in isoform 2. Add BLAST | 52 | |
Alternative sequenceiVSP_060600 | 91 | Missing in isoform 7. | 1 | |
Alternative sequenceiVSP_060601 | 122 | L → LQ in isoform 6, isoform 7, isoform 5 and isoform 4. | 1 | |
Alternative sequenceiVSP_060602 | 167 – 189 | Missing in isoform 6. Add BLAST | 23 | |
Alternative sequenceiVSP_060603 | 857 | N → NPCSPS in isoform 5. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51477 mRNA Translation: AAC50478.1 U94905 mRNA Translation: AAB60859.1 Frameshift. AK124594 mRNA Translation: BAC85894.1 AK294888 mRNA Translation: BAH11915.1 AK300577 mRNA Translation: BAH13309.1 AK225774 mRNA No translation available. AC116021 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68008.1 BC041770 mRNA Translation: AAH41770.1 |
CCDSi | CCDS41640.1 [Q13574-1] CCDS44579.2 [Q13574-7] CCDS44580.1 [Q13574-4] CCDS55757.1 [Q13574-5] CCDS55758.1 [Q13574-6] CCDS55759.1 [Q13574-2] CCDS7918.1 [Q13574-3] |
RefSeqi | NP_001099010.1, NM_001105540.1 [Q13574-1] NP_001186195.1, NM_001199266.1 [Q13574-5] NP_001186196.1, NM_001199267.1 [Q13574-2] NP_001186197.1, NM_001199268.1 [Q13574-6] NP_003637.2, NM_003646.3 [Q13574-4] NP_963290.1, NM_201532.2 [Q13574-3] NP_963291.2, NM_201533.3 [Q13574-7] |
Genome annotation databases
Ensembli | ENST00000318201; ENSP00000320340; ENSG00000149091 [Q13574-6] ENST00000343674; ENSP00000343065; ENSG00000149091 [Q13574-3] ENST00000421244; ENSP00000391021; ENSG00000149091 [Q13574-4] ENST00000454345; ENSP00000412178; ENSG00000149091 [Q13574-1] ENST00000456247; ENSP00000395684; ENSG00000149091 [Q13574-2] ENST00000527911; ENSP00000436291; ENSG00000149091 [Q13574-5] ENST00000532868; ENSP00000436273; ENSG00000149091 [Q13574-7] |
GeneIDi | 8525 |
KEGGi | hsa:8525 |
UCSCi | uc001nch.2, human [Q13574-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51477 mRNA Translation: AAC50478.1 U94905 mRNA Translation: AAB60859.1 Frameshift. AK124594 mRNA Translation: BAC85894.1 AK294888 mRNA Translation: BAH11915.1 AK300577 mRNA Translation: BAH13309.1 AK225774 mRNA No translation available. AC116021 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68008.1 BC041770 mRNA Translation: AAH41770.1 |
CCDSi | CCDS41640.1 [Q13574-1] CCDS44579.2 [Q13574-7] CCDS44580.1 [Q13574-4] CCDS55757.1 [Q13574-5] CCDS55758.1 [Q13574-6] CCDS55759.1 [Q13574-2] CCDS7918.1 [Q13574-3] |
RefSeqi | NP_001099010.1, NM_001105540.1 [Q13574-1] NP_001186195.1, NM_001199266.1 [Q13574-5] NP_001186196.1, NM_001199267.1 [Q13574-2] NP_001186197.1, NM_001199268.1 [Q13574-6] NP_003637.2, NM_003646.3 [Q13574-4] NP_963290.1, NM_201532.2 [Q13574-3] NP_963291.2, NM_201533.3 [Q13574-7] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5ELQ | X-ray | 1.10 | C/P | 921-928 | [»] | |
SMRi | Q13574 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114095, 76 interactors |
CORUMi | Q13574 |
IntActi | Q13574, 16 interactors |
MINTi | Q13574 |
STRINGi | 9606.ENSP00000412178 |
Chemistry databases
BindingDBi | Q13574 |
ChEMBLi | CHEMBL4105942 |
DrugBanki | DB14001, alpha-Tocopherol succinate |
SwissLipidsi | SLP:000000547 SLP:000000921 [Q13574-1] SLP:000000922 [Q13574-2] |
PTM databases
iPTMneti | Q13574 |
MetOSitei | Q13574 |
PhosphoSitePlusi | Q13574 |
Genetic variation databases
BioMutai | DGKZ |
DMDMi | 215274170 |
Proteomic databases
EPDi | Q13574 |
jPOSTi | Q13574 |
MassIVEi | Q13574 |
MaxQBi | Q13574 |
PaxDbi | Q13574 |
PeptideAtlasi | Q13574 |
PRIDEi | Q13574 |
ProteomicsDBi | 22840 32183 59578 [Q13574-1] 59579 [Q13574-2] 59580 [Q13574-3] 6789 |
Protocols and materials databases
Antibodypediai | 26268, 231 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 8525 |
DisGeNETi | 8525 |
GeneCardsi | DGKZ |
HGNCi | HGNC:2857, DGKZ |
HPAi | ENSG00000149091, Tissue enhanced (brain) |
MIMi | 601441, gene |
neXtProti | NX_Q13574 |
OpenTargetsi | ENSG00000149091 |
PharmGKBi | PA27318 |
VEuPathDBi | HostDB:ENSG00000149091.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0782, Eukaryota |
GeneTreei | ENSGT00940000156152 |
InParanoidi | Q13574 |
OMAi | GEPCKLT |
OrthoDBi | 274339at2759 |
PhylomeDBi | Q13574 |
TreeFami | TF312817 |
Enzyme and pathway databases
UniPathwayi | UPA00230 |
BRENDAi | 2.7.1.107, 2681 |
PathwayCommonsi | Q13574 |
Reactomei | R-HSA-114508, Effects of PIP2 hydrolysis |
SIGNORi | Q13574 |
Miscellaneous databases
BioGRID-ORCSi | 8525, 9 hits in 998 CRISPR screens |
ChiTaRSi | DGKZ, human |
GeneWikii | DGKZ |
GenomeRNAii | 8525 |
Pharosi | Q13574, Tbio |
PROi | PR:Q13574 |
RNActi | Q13574, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149091, Expressed in right frontal lobe and 124 other tissues |
ExpressionAtlasi | Q13574, baseline and differential |
Genevisiblei | Q13574, HS |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 1.25.40.20, 1 hit 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR017438, ATP-NAD_kinase_N IPR037607, DGK IPR000756, Diacylglycerol_kin_accessory IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf IPR002219, PE/DAG-bd |
PANTHERi | PTHR11255, PTHR11255, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00130, C1_1, 1 hit PF00609, DAGK_acc, 1 hit PF00781, DAGK_cat, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00109, C1, 2 hits SM00045, DAGKa, 1 hit SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits PS50146, DAGK, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DGKZ_HUMAN | |
Accessioni | Q13574Primary (citable) accession number: Q13574 Secondary accession number(s): B7Z2M9 Q8IVW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | June 17, 2020 | |
Last modified: | April 7, 2021 | |
This is version 205 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families