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Protein

Diacylglycerol kinase zeta

Gene

DGKZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity (PubMed:11257115). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Activates PIP5K1A activity via generation of phosphatidic acid (PubMed:15157668).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri287 – 341Phorbol-ester/DAG-type 1Add BLAST55
Zinc fingeri361 – 419Phorbol-ester/DAG-type 2Add BLAST59

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: ProtInc
  • diacylglycerol kinase activity Source: BHF-UCL
  • kinase activity Source: BHF-UCL
  • lipid kinase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • NAD+ kinase activity Source: InterPro
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.1.107 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-114508 Effects of PIP2 hydrolysis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13574

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000547
SLP:000000921 [Q13574-1]
SLP:000000922 [Q13574-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol kinase zeta (EC:2.7.1.107)
Short name:
DAG kinase zeta
Alternative name(s):
Diglyceride kinase zeta
Short name:
DGK-zeta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DGKZ
Synonyms:DAGK6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000149091.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2857 DGKZ

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601441 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13574

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1115 – 1116TA → NS: Loss of interaction with SNTG1. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
8525

Open Targets

More...
OpenTargetsi
ENSG00000149091

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27318

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DGKZ

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274170

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002184681 – 1117Diacylglycerol kinase zetaAdd BLAST1117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei894PhosphoserineCombined sources1
Modified residuei970PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13574

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13574

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13574

PeptideAtlas

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PeptideAtlasi
Q13574

PRoteomics IDEntifications database

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PRIDEi
Q13574

ProteomicsDB human proteome resource

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ProteomicsDBi
59578
59579 [Q13574-2]
59580 [Q13574-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13574

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13574

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149091 Expressed in 102 organ(s), highest expression level in right frontal lobe

CleanEx database of gene expression profiles

More...
CleanExi
HS_DGKZ

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13574 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13574 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA051336

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS (PubMed:11257115, PubMed:11352924, PubMed:17351151). Interacts with IRS1 in the absence of insulin; insulin stimulation decreases this interaction (By similarity). Found in a ternary complex with IRS1 and PIP5K1A in the absence of insulin (By similarity). Interacts with PIP5K1A (PubMed:15157668).By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114095, 69 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13574

Protein interaction database and analysis system

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IntActi
Q13574, 12 interactors

Molecular INTeraction database

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MINTi
Q13574

STRING: functional protein association networks

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STRINGi
9606.ENSP00000412178

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13574

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13574

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini480 – 614DAGKcPROSITE-ProRule annotationAdd BLAST135
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1011 – 1041ANK 1Add BLAST31
Repeati1046 – 1075ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni448 – 462MARCKS homologyAdd BLAST15
Regioni467 – 605Mediates interaction with RASGRP1Add BLAST139

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi550 – 558Nuclear export signalBy similarity9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi256 – 261Poly-Pro6
Compositional biasi448 – 451Poly-Lys4
Compositional biasi560 – 563Poly-Pro4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri287 – 341Phorbol-ester/DAG-type 1Add BLAST55
Zinc fingeri361 – 419Phorbol-ester/DAG-type 2Add BLAST59

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0782 Eukaryota
ENOG410XSCB LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156152

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231472

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG067303

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13574

KEGG Orthology (KO)

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KOi
K00901

Identification of Orthologs from Complete Genome Data

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OMAi
NPGEHHD

Database of Orthologous Groups

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OrthoDBi
EOG091G13Z8

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13574

TreeFam database of animal gene trees

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TreeFami
TF312817

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit
cd00029 C1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 1 hit
3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd

The PANTHER Classification System

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PANTHERi
PTHR11255 PTHR11255, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF00130 C1_1, 1 hit
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248 ANK, 2 hits
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF111331 SSF111331, 1 hit
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50146 DAGK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13574-1) [UniParc]FASTAAdd to basket
Also known as: Long, zeta2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METFFRRHFR GKVPGPGEGQ QRPSSVGLPT GKARRRSPAG QASSSLAQRR
60 70 80 90 100
RSSAQLQGCL LSCGVRAQGS SRRRSSTVPP SCNPRFIVDK VLTPQPTTVG
110 120 130 140 150
AQLLGAPLLL TGLVGMNEEE GVQEDVVAEA SSAIQPGTKT PGPPPPRGAQ
160 170 180 190 200
PLLPLPRYLR RASSHLLPAD AVYDHALWGL HGYYRRLSQR RPSGQHPGPG
210 220 230 240 250
GRRASGTTAG TMLPTRVRPL SRRRQVALRR KAAGPQAWSA LLAKAITKSG
260 270 280 290 300
LQHLAPPPPT PGAPCSESER QIRSTVDWSE SATYGEHIWF ETNVSGDFCY
310 320 330 340 350
VGEQYCVARM LKSVSRRKCA ACKIVVHTPC IEQLEKINFR CKPSFRESGS
360 370 380 390 400
RNVREPTFVR HHWVHRRRQD GKCRHCGKGF QQKFTFHSKE IVAISCSWCK
410 420 430 440 450
QAYHSKVSCF MLQQIEEPCS LGVHAAVVIP PTWILRARRP QNTLKASKKK
460 470 480 490 500
KRASFKRKSS KKGPEEGRWR PFIIRPTPSP LMKPLLVFVN PKSGGNQGAK
510 520 530 540 550
IIQSFLWYLN PRQVFDLSQG GPKEALEMYR KVHNLRILAC GGDGTVGWIL
560 570 580 590 600
STLDQLRLKP PPPVAILPLG TGNDLARTLN WGGGYTDEPV SKILSHVEEG
610 620 630 640 650
NVVQLDRWDL HAEPNPEAGP EDRDEGATDR LPLDVFNNYF SLGFDAHVTL
660 670 680 690 700
EFHESREANP EKFNSRFRNK MFYAGTAFSD FLMGSSKDLA KHIRVVCDGM
710 720 730 740 750
DLTPKIQDLK PQCVVFLNIP RYCAGTMPWG HPGEHHDFEP QRHDDGYLEV
760 770 780 790 800
IGFTMTSLAA LQVGGHGERL TQCREVVLTT SKAIPVQVDG EPCKLAASRI
810 820 830 840 850
RIALRNQATM VQKAKRRSAA PLHSDQQPVP EQLRIQVSRV SMHDYEALHY
860 870 880 890 900
DKEQLKEASV PLGTVVVPGD SDLELCRAHI ERLQQEPDGA GAKSPTCQKL
910 920 930 940 950
SPKWCFLDAT TASRFYRIDR AQEHLNYVTE IAQDEIYILD PELLGASARP
960 970 980 990 1000
DLPTPTSPLP TSPCSPTPRS LQGDAAPPQG EELIEAAKRN DFCKLQELHR
1010 1020 1030 1040 1050
AGGDLMHRDE QSRTLLHHAV STGSKDVVRY LLDHAPPEIL DAVEENGETC
1060 1070 1080 1090 1100
LHQAAALGQR TICHYIVEAG ASLMKTDQQG DTPRQRAEKA QDTELAAYLE
1110
NRQHYQMIQR EDQETAV
Note: Minor isoform.
Length:1,117
Mass (Da):124,128
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3A7C2382ECF549B
GO
Isoform 2 (identifier: Q13574-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR

Note: Major isoform.
Show »
Length:928
Mass (Da):103,981
Checksum:i7936A979CB3D35AA
GO
Isoform 3 (identifier: Q13574-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: METFFRRHFR...SCGVRAQGSS → MAEGQGGGGQ...LHLRKQVSYR
     72-243: Missing.

Note: No experimental confirmation available.
Show »
Length:945
Mass (Da):106,030
Checksum:i6EF612B9FE91F7E7
GO
Isoform 4 (identifier: Q13574-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ

Note: No experimental confirmation available.
Show »
Length:929
Mass (Da):104,109
Checksum:i362346DD9046B323
GO
Isoform 5 (identifier: Q13574-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ
     1046-1046: N → NPCSPS

Note: No experimental confirmation available.
Show »
Length:934
Mass (Da):104,581
Checksum:i3B9CEB5C58B865F7
GO
Isoform 6 (identifier: Q13574-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ
     356-378: Missing.

Note: No experimental confirmation available.
Show »
Length:906
Mass (Da):101,230
Checksum:i99789AD08DCCB5BD
GO
Isoform 7 (identifier: Q13574-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MSAPGAGHSA...QIPSEAPQTQ
     280-280: Missing.
     311-311: L → LQ

Note: No experimental confirmation available.
Show »
Length:933
Mass (Da):104,296
Checksum:i57D46241E25FC58C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNL8E9PNL8_HUMAN
Diacylglycerol kinase
DGKZ
707Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDN6H0YDN6_HUMAN
Diacylglycerol kinase zeta
DGKZ
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNZ3E9PNZ3_HUMAN
Diacylglycerol kinase zeta
DGKZ
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEG2H0YEG2_HUMAN
Diacylglycerol kinase zeta
DGKZ
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK94E9PK94_HUMAN
Diacylglycerol kinase zeta
DGKZ
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKT3E9PKT3_HUMAN
Diacylglycerol kinase zeta
DGKZ
16Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB60859 differs from that shown. Reason: Frameshift at positions 166 and 167.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159L → V in AAB60859 (PubMed:9159104).Curated1
Sequence conflicti494G → W in BAH11915 (PubMed:14702039).Curated1
Sequence conflicti783A → S in BAH11915 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04737121Q → R1 PublicationCorresponds to variant dbSNP:rs1317826Ensembl.1
Natural variantiVAR_06113169G → C. Corresponds to variant dbSNP:rs901998Ensembl.1
Natural variantiVAR_069059712Q → K1 PublicationCorresponds to variant dbSNP:rs17854149Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0012681 – 243METFF…SALLA → MEPRDGSPEARSSDSESASA SSSGSERDAGPEPDKAPRRL NKRRFPGLRLFGHR in isoform 2, isoform 4, isoform 5 and isoform 6. 4 PublicationsAdd BLAST243
Alternative sequenceiVSP_0551471 – 243METFF…SALLA → MSAPGAGHSAGGSCNESSAL GPVEALGTEEGERPGSLRQM WRYRSWDVPQIPSEAPQTQ in isoform 7. CuratedAdd BLAST243
Alternative sequenceiVSP_0431631 – 71METFF…AQGSS → MAEGQGGGGQRWDWAGGGRA AEEEVVRRRCRRGEEAQVAQ PWPEGSRGTAAGPPVEERFR QLHLRKQVSYR in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_04316472 – 243Missing in isoform 3. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_055148280Missing in isoform 7. Curated1
Alternative sequenceiVSP_045628311L → LQ in isoform 4, isoform 5, isoform 6 and isoform 7. 3 Publications1
Alternative sequenceiVSP_046919356 – 378Missing in isoform 6. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0469201046N → NPCSPS in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U51477 mRNA Translation: AAC50478.1
U94905 mRNA Translation: AAB60859.1 Frameshift.
AK124594 mRNA Translation: BAC85894.1
AK294888 mRNA Translation: BAH11915.1
AK300577 mRNA Translation: BAH13309.1
AK225774 mRNA No translation available.
AC116021 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68008.1
BC041770 mRNA Translation: AAH41770.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41640.1 [Q13574-1]
CCDS44579.2 [Q13574-7]
CCDS44580.1 [Q13574-4]
CCDS55757.1 [Q13574-5]
CCDS55758.1 [Q13574-6]
CCDS55759.1 [Q13574-2]
CCDS7918.1 [Q13574-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001099010.1, NM_001105540.1 [Q13574-1]
NP_001186195.1, NM_001199266.1 [Q13574-5]
NP_001186196.1, NM_001199267.1 [Q13574-2]
NP_001186197.1, NM_001199268.1 [Q13574-6]
NP_003637.2, NM_003646.3 [Q13574-4]
NP_963290.1, NM_201532.2 [Q13574-3]
NP_963291.2, NM_201533.3 [Q13574-7]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.502461

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000318201; ENSP00000320340; ENSG00000149091 [Q13574-6]
ENST00000343674; ENSP00000343065; ENSG00000149091 [Q13574-3]
ENST00000421244; ENSP00000391021; ENSG00000149091 [Q13574-4]
ENST00000454345; ENSP00000412178; ENSG00000149091 [Q13574-1]
ENST00000456247; ENSP00000395684; ENSG00000149091 [Q13574-2]
ENST00000527911; ENSP00000436291; ENSG00000149091 [Q13574-5]
ENST00000532868; ENSP00000436273; ENSG00000149091 [Q13574-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8525

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8525

UCSC genome browser

More...
UCSCi
uc001nch.2 human [Q13574-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51477 mRNA Translation: AAC50478.1
U94905 mRNA Translation: AAB60859.1 Frameshift.
AK124594 mRNA Translation: BAC85894.1
AK294888 mRNA Translation: BAH11915.1
AK300577 mRNA Translation: BAH13309.1
AK225774 mRNA No translation available.
AC116021 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68008.1
BC041770 mRNA Translation: AAH41770.1
CCDSiCCDS41640.1 [Q13574-1]
CCDS44579.2 [Q13574-7]
CCDS44580.1 [Q13574-4]
CCDS55757.1 [Q13574-5]
CCDS55758.1 [Q13574-6]
CCDS55759.1 [Q13574-2]
CCDS7918.1 [Q13574-3]
RefSeqiNP_001099010.1, NM_001105540.1 [Q13574-1]
NP_001186195.1, NM_001199266.1 [Q13574-5]
NP_001186196.1, NM_001199267.1 [Q13574-2]
NP_001186197.1, NM_001199268.1 [Q13574-6]
NP_003637.2, NM_003646.3 [Q13574-4]
NP_963290.1, NM_201532.2 [Q13574-3]
NP_963291.2, NM_201533.3 [Q13574-7]
UniGeneiHs.502461

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ELQX-ray1.10C/P1110-1117[»]
ProteinModelPortaliQ13574
SMRiQ13574
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114095, 69 interactors
CORUMiQ13574
IntActiQ13574, 12 interactors
MINTiQ13574
STRINGi9606.ENSP00000412178

Chemistry databases

SwissLipidsiSLP:000000547
SLP:000000921 [Q13574-1]
SLP:000000922 [Q13574-2]

PTM databases

iPTMnetiQ13574
PhosphoSitePlusiQ13574

Polymorphism and mutation databases

BioMutaiDGKZ
DMDMi215274170

Proteomic databases

EPDiQ13574
MaxQBiQ13574
PaxDbiQ13574
PeptideAtlasiQ13574
PRIDEiQ13574
ProteomicsDBi59578
59579 [Q13574-2]
59580 [Q13574-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318201; ENSP00000320340; ENSG00000149091 [Q13574-6]
ENST00000343674; ENSP00000343065; ENSG00000149091 [Q13574-3]
ENST00000421244; ENSP00000391021; ENSG00000149091 [Q13574-4]
ENST00000454345; ENSP00000412178; ENSG00000149091 [Q13574-1]
ENST00000456247; ENSP00000395684; ENSG00000149091 [Q13574-2]
ENST00000527911; ENSP00000436291; ENSG00000149091 [Q13574-5]
ENST00000532868; ENSP00000436273; ENSG00000149091 [Q13574-7]
GeneIDi8525
KEGGihsa:8525
UCSCiuc001nch.2 human [Q13574-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8525
DisGeNETi8525
EuPathDBiHostDB:ENSG00000149091.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DGKZ

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0009600
HIX0037561
HGNCiHGNC:2857 DGKZ
HPAiHPA051336
MIMi601441 gene
neXtProtiNX_Q13574
OpenTargetsiENSG00000149091
PharmGKBiPA27318

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0782 Eukaryota
ENOG410XSCB LUCA
GeneTreeiENSGT00940000156152
HOGENOMiHOG000231472
HOVERGENiHBG067303
InParanoidiQ13574
KOiK00901
OMAiNPGEHHD
OrthoDBiEOG091G13Z8
PhylomeDBiQ13574
TreeFamiTF312817

Enzyme and pathway databases

BRENDAi2.7.1.107 2681
ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis
SIGNORiQ13574

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DGKZ human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DGKZ

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8525

Protein Ontology

More...
PROi
PR:Q13574

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149091 Expressed in 102 organ(s), highest expression level in right frontal lobe
CleanExiHS_DGKZ
ExpressionAtlasiQ13574 baseline and differential
GenevisibleiQ13574 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
cd00029 C1, 1 hit
Gene3Di1.25.40.20, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00130 C1_1, 1 hit
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50146 DAGK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGKZ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13574
Secondary accession number(s): B7Z2M9
, B7Z6M3, E9PPW4, F6UCU9, G3V0F6, J3KNJ6, O00542, Q6ZVG7, Q8IVW9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: December 5, 2018
This is version 188 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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