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Protein

Diacylglycerol kinase zeta

Gene

DGKZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity (PubMed:11257115). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Activates PIP5K1A activity via generation of phosphatidic acid (PubMed:15157668).By similarity2 Publications

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri287 – 341Phorbol-ester/DAG-type 1Add BLAST55
Zinc fingeri361 – 419Phorbol-ester/DAG-type 2Add BLAST59

GO - Molecular functioni

  • ATP binding Source: ProtInc
  • diacylglycerol kinase activity Source: BHF-UCL
  • kinase activity Source: BHF-UCL
  • lipid kinase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • NAD+ kinase activity Source: InterPro
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.1.107 2681
ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis
SIGNORiQ13574

Chemistry databases

SwissLipidsiSLP:000000547
SLP:000000921 [Q13574-1]
SLP:000000922 [Q13574-2]

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase zeta (EC:2.7.1.107)
Short name:
DAG kinase zeta
Alternative name(s):
Diglyceride kinase zeta
Short name:
DGK-zeta
Gene namesi
Name:DGKZ
Synonyms:DAGK6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149091.15
HGNCiHGNC:2857 DGKZ
MIMi601441 gene
neXtProtiNX_Q13574

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1115 – 1116TA → NS: Loss of interaction with SNTG1. 1 Publication2

Organism-specific databases

DisGeNETi8525
OpenTargetsiENSG00000149091
PharmGKBiPA27318

Polymorphism and mutation databases

BioMutaiDGKZ
DMDMi215274170

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002184681 – 1117Diacylglycerol kinase zetaAdd BLAST1117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei894PhosphoserineCombined sources1
Modified residuei970PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13574
MaxQBiQ13574
PaxDbiQ13574
PeptideAtlasiQ13574
PRIDEiQ13574
ProteomicsDBi59578
59579 [Q13574-2]
59580 [Q13574-3]

PTM databases

iPTMnetiQ13574
PhosphoSitePlusiQ13574

Expressioni

Tissue specificityi

Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.

Gene expression databases

BgeeiENSG00000149091 Expressed in 102 organ(s), highest expression level in right frontal lobe
CleanExiHS_DGKZ
ExpressionAtlasiQ13574 baseline and differential
GenevisibleiQ13574 HS

Organism-specific databases

HPAiHPA051336

Interactioni

Subunit structurei

Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS (PubMed:11257115, PubMed:11352924, PubMed:17351151). Interacts with IRS1 in the absence of insulin; insulin stimulation decreases this interaction (By similarity). Found in a ternary complex with IRS1 and PIP5K1A in the absence of insulin (By similarity). Interacts with PIP5K1A (PubMed:15157668).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114095, 69 interactors
CORUMiQ13574
IntActiQ13574, 12 interactors
MINTiQ13574
STRINGi9606.ENSP00000412178

Structurei

Secondary structure

11117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13574
SMRiQ13574
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini480 – 614DAGKcPROSITE-ProRule annotationAdd BLAST135
Repeati1011 – 1041ANK 1Add BLAST31
Repeati1046 – 1075ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni448 – 462MARCKS homologyAdd BLAST15
Regioni467 – 605Mediates interaction with RASGRP1Add BLAST139

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi550 – 558Nuclear export signalBy similarity9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi256 – 261Poly-Pro6
Compositional biasi448 – 451Poly-Lys4
Compositional biasi560 – 563Poly-Pro4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri287 – 341Phorbol-ester/DAG-type 1Add BLAST55
Zinc fingeri361 – 419Phorbol-ester/DAG-type 2Add BLAST59

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0782 Eukaryota
ENOG410XSCB LUCA
GeneTreeiENSGT00760000119050
HOGENOMiHOG000231472
HOVERGENiHBG067303
InParanoidiQ13574
KOiK00901
OMAiNPGEHHD
OrthoDBiEOG091G13Z8
PhylomeDBiQ13574
TreeFamiTF312817

Family and domain databases

CDDicd00204 ANK, 1 hit
cd00029 C1, 1 hit
Gene3Di1.25.40.20, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00130 C1_1, 1 hit
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50146 DAGK, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13574-1) [UniParc]FASTAAdd to basket
Also known as: Long, zeta2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METFFRRHFR GKVPGPGEGQ QRPSSVGLPT GKARRRSPAG QASSSLAQRR
60 70 80 90 100
RSSAQLQGCL LSCGVRAQGS SRRRSSTVPP SCNPRFIVDK VLTPQPTTVG
110 120 130 140 150
AQLLGAPLLL TGLVGMNEEE GVQEDVVAEA SSAIQPGTKT PGPPPPRGAQ
160 170 180 190 200
PLLPLPRYLR RASSHLLPAD AVYDHALWGL HGYYRRLSQR RPSGQHPGPG
210 220 230 240 250
GRRASGTTAG TMLPTRVRPL SRRRQVALRR KAAGPQAWSA LLAKAITKSG
260 270 280 290 300
LQHLAPPPPT PGAPCSESER QIRSTVDWSE SATYGEHIWF ETNVSGDFCY
310 320 330 340 350
VGEQYCVARM LKSVSRRKCA ACKIVVHTPC IEQLEKINFR CKPSFRESGS
360 370 380 390 400
RNVREPTFVR HHWVHRRRQD GKCRHCGKGF QQKFTFHSKE IVAISCSWCK
410 420 430 440 450
QAYHSKVSCF MLQQIEEPCS LGVHAAVVIP PTWILRARRP QNTLKASKKK
460 470 480 490 500
KRASFKRKSS KKGPEEGRWR PFIIRPTPSP LMKPLLVFVN PKSGGNQGAK
510 520 530 540 550
IIQSFLWYLN PRQVFDLSQG GPKEALEMYR KVHNLRILAC GGDGTVGWIL
560 570 580 590 600
STLDQLRLKP PPPVAILPLG TGNDLARTLN WGGGYTDEPV SKILSHVEEG
610 620 630 640 650
NVVQLDRWDL HAEPNPEAGP EDRDEGATDR LPLDVFNNYF SLGFDAHVTL
660 670 680 690 700
EFHESREANP EKFNSRFRNK MFYAGTAFSD FLMGSSKDLA KHIRVVCDGM
710 720 730 740 750
DLTPKIQDLK PQCVVFLNIP RYCAGTMPWG HPGEHHDFEP QRHDDGYLEV
760 770 780 790 800
IGFTMTSLAA LQVGGHGERL TQCREVVLTT SKAIPVQVDG EPCKLAASRI
810 820 830 840 850
RIALRNQATM VQKAKRRSAA PLHSDQQPVP EQLRIQVSRV SMHDYEALHY
860 870 880 890 900
DKEQLKEASV PLGTVVVPGD SDLELCRAHI ERLQQEPDGA GAKSPTCQKL
910 920 930 940 950
SPKWCFLDAT TASRFYRIDR AQEHLNYVTE IAQDEIYILD PELLGASARP
960 970 980 990 1000
DLPTPTSPLP TSPCSPTPRS LQGDAAPPQG EELIEAAKRN DFCKLQELHR
1010 1020 1030 1040 1050
AGGDLMHRDE QSRTLLHHAV STGSKDVVRY LLDHAPPEIL DAVEENGETC
1060 1070 1080 1090 1100
LHQAAALGQR TICHYIVEAG ASLMKTDQQG DTPRQRAEKA QDTELAAYLE
1110
NRQHYQMIQR EDQETAV
Note: Minor isoform.
Length:1,117
Mass (Da):124,128
Last modified:November 25, 2008 - v3
Checksum:iF3A7C2382ECF549B
GO
Isoform 2 (identifier: Q13574-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR

Note: Major isoform.
Show »
Length:928
Mass (Da):103,981
Checksum:i7936A979CB3D35AA
GO
Isoform 3 (identifier: Q13574-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: METFFRRHFR...SCGVRAQGSS → MAEGQGGGGQ...LHLRKQVSYR
     72-243: Missing.

Note: No experimental confirmation available.
Show »
Length:945
Mass (Da):106,030
Checksum:i6EF612B9FE91F7E7
GO
Isoform 4 (identifier: Q13574-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ

Note: No experimental confirmation available.
Show »
Length:929
Mass (Da):104,109
Checksum:i362346DD9046B323
GO
Isoform 5 (identifier: Q13574-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ
     1046-1046: N → NPCSPS

Note: No experimental confirmation available.
Show »
Length:934
Mass (Da):104,581
Checksum:i3B9CEB5C58B865F7
GO
Isoform 6 (identifier: Q13574-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ
     356-378: Missing.

Note: No experimental confirmation available.
Show »
Length:906
Mass (Da):101,230
Checksum:i99789AD08DCCB5BD
GO
Isoform 7 (identifier: Q13574-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MSAPGAGHSA...QIPSEAPQTQ
     280-280: Missing.
     311-311: L → LQ

Note: No experimental confirmation available.
Show »
Length:933
Mass (Da):104,296
Checksum:i57D46241E25FC58C
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNL8E9PNL8_HUMAN
Diacylglycerol kinase
DGKZ
707Annotation score:
H0YEG2H0YEG2_HUMAN
Diacylglycerol kinase zeta
DGKZ
98Annotation score:
H0YDN6H0YDN6_HUMAN
Diacylglycerol kinase zeta
DGKZ
197Annotation score:
E9PNZ3E9PNZ3_HUMAN
Diacylglycerol kinase zeta
DGKZ
135Annotation score:
E9PK94E9PK94_HUMAN
Diacylglycerol kinase zeta
DGKZ
54Annotation score:
E9PKT3E9PKT3_HUMAN
Diacylglycerol kinase zeta
DGKZ
16Annotation score:

Sequence cautioni

The sequence AAB60859 differs from that shown. Reason: Frameshift at positions 166 and 167.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159L → V in AAB60859 (PubMed:9159104).Curated1
Sequence conflicti494G → W in BAH11915 (PubMed:14702039).Curated1
Sequence conflicti783A → S in BAH11915 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04737121Q → R1 PublicationCorresponds to variant dbSNP:rs1317826Ensembl.1
Natural variantiVAR_06113169G → C. Corresponds to variant dbSNP:rs901998Ensembl.1
Natural variantiVAR_069059712Q → K1 PublicationCorresponds to variant dbSNP:rs17854149Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0012681 – 243METFF…SALLA → MEPRDGSPEARSSDSESASA SSSGSERDAGPEPDKAPRRL NKRRFPGLRLFGHR in isoform 2, isoform 4, isoform 5 and isoform 6. 4 PublicationsAdd BLAST243
Alternative sequenceiVSP_0551471 – 243METFF…SALLA → MSAPGAGHSAGGSCNESSAL GPVEALGTEEGERPGSLRQM WRYRSWDVPQIPSEAPQTQ in isoform 7. CuratedAdd BLAST243
Alternative sequenceiVSP_0431631 – 71METFF…AQGSS → MAEGQGGGGQRWDWAGGGRA AEEEVVRRRCRRGEEAQVAQ PWPEGSRGTAAGPPVEERFR QLHLRKQVSYR in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_04316472 – 243Missing in isoform 3. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_055148280Missing in isoform 7. Curated1
Alternative sequenceiVSP_045628311L → LQ in isoform 4, isoform 5, isoform 6 and isoform 7. 3 Publications1
Alternative sequenceiVSP_046919356 – 378Missing in isoform 6. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0469201046N → NPCSPS in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51477 mRNA Translation: AAC50478.1
U94905 mRNA Translation: AAB60859.1 Frameshift.
AK124594 mRNA Translation: BAC85894.1
AK294888 mRNA Translation: BAH11915.1
AK300577 mRNA Translation: BAH13309.1
AK225774 mRNA No translation available.
AC116021 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68008.1
BC041770 mRNA Translation: AAH41770.1
CCDSiCCDS41640.1 [Q13574-1]
CCDS44579.2 [Q13574-7]
CCDS44580.1 [Q13574-4]
CCDS55757.1 [Q13574-5]
CCDS55758.1 [Q13574-6]
CCDS55759.1 [Q13574-2]
CCDS7918.1 [Q13574-3]
RefSeqiNP_001099010.1, NM_001105540.1 [Q13574-1]
NP_001186195.1, NM_001199266.1 [Q13574-5]
NP_001186196.1, NM_001199267.1 [Q13574-2]
NP_001186197.1, NM_001199268.1 [Q13574-6]
NP_003637.2, NM_003646.3 [Q13574-4]
NP_963290.1, NM_201532.2 [Q13574-3]
NP_963291.2, NM_201533.3 [Q13574-7]
UniGeneiHs.502461

Genome annotation databases

EnsembliENST00000318201; ENSP00000320340; ENSG00000149091 [Q13574-6]
ENST00000343674; ENSP00000343065; ENSG00000149091 [Q13574-3]
ENST00000421244; ENSP00000391021; ENSG00000149091 [Q13574-4]
ENST00000454345; ENSP00000412178; ENSG00000149091 [Q13574-1]
ENST00000456247; ENSP00000395684; ENSG00000149091 [Q13574-2]
ENST00000527911; ENSP00000436291; ENSG00000149091 [Q13574-5]
ENST00000532868; ENSP00000436273; ENSG00000149091 [Q13574-7]
GeneIDi8525
KEGGihsa:8525
UCSCiuc001nch.2 human [Q13574-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51477 mRNA Translation: AAC50478.1
U94905 mRNA Translation: AAB60859.1 Frameshift.
AK124594 mRNA Translation: BAC85894.1
AK294888 mRNA Translation: BAH11915.1
AK300577 mRNA Translation: BAH13309.1
AK225774 mRNA No translation available.
AC116021 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68008.1
BC041770 mRNA Translation: AAH41770.1
CCDSiCCDS41640.1 [Q13574-1]
CCDS44579.2 [Q13574-7]
CCDS44580.1 [Q13574-4]
CCDS55757.1 [Q13574-5]
CCDS55758.1 [Q13574-6]
CCDS55759.1 [Q13574-2]
CCDS7918.1 [Q13574-3]
RefSeqiNP_001099010.1, NM_001105540.1 [Q13574-1]
NP_001186195.1, NM_001199266.1 [Q13574-5]
NP_001186196.1, NM_001199267.1 [Q13574-2]
NP_001186197.1, NM_001199268.1 [Q13574-6]
NP_003637.2, NM_003646.3 [Q13574-4]
NP_963290.1, NM_201532.2 [Q13574-3]
NP_963291.2, NM_201533.3 [Q13574-7]
UniGeneiHs.502461

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ELQX-ray1.10C/P1110-1117[»]
ProteinModelPortaliQ13574
SMRiQ13574
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114095, 69 interactors
CORUMiQ13574
IntActiQ13574, 12 interactors
MINTiQ13574
STRINGi9606.ENSP00000412178

Chemistry databases

SwissLipidsiSLP:000000547
SLP:000000921 [Q13574-1]
SLP:000000922 [Q13574-2]

PTM databases

iPTMnetiQ13574
PhosphoSitePlusiQ13574

Polymorphism and mutation databases

BioMutaiDGKZ
DMDMi215274170

Proteomic databases

EPDiQ13574
MaxQBiQ13574
PaxDbiQ13574
PeptideAtlasiQ13574
PRIDEiQ13574
ProteomicsDBi59578
59579 [Q13574-2]
59580 [Q13574-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318201; ENSP00000320340; ENSG00000149091 [Q13574-6]
ENST00000343674; ENSP00000343065; ENSG00000149091 [Q13574-3]
ENST00000421244; ENSP00000391021; ENSG00000149091 [Q13574-4]
ENST00000454345; ENSP00000412178; ENSG00000149091 [Q13574-1]
ENST00000456247; ENSP00000395684; ENSG00000149091 [Q13574-2]
ENST00000527911; ENSP00000436291; ENSG00000149091 [Q13574-5]
ENST00000532868; ENSP00000436273; ENSG00000149091 [Q13574-7]
GeneIDi8525
KEGGihsa:8525
UCSCiuc001nch.2 human [Q13574-1]

Organism-specific databases

CTDi8525
DisGeNETi8525
EuPathDBiHostDB:ENSG00000149091.15
GeneCardsiDGKZ
H-InvDBiHIX0009600
HIX0037561
HGNCiHGNC:2857 DGKZ
HPAiHPA051336
MIMi601441 gene
neXtProtiNX_Q13574
OpenTargetsiENSG00000149091
PharmGKBiPA27318
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0782 Eukaryota
ENOG410XSCB LUCA
GeneTreeiENSGT00760000119050
HOGENOMiHOG000231472
HOVERGENiHBG067303
InParanoidiQ13574
KOiK00901
OMAiNPGEHHD
OrthoDBiEOG091G13Z8
PhylomeDBiQ13574
TreeFamiTF312817

Enzyme and pathway databases

BRENDAi2.7.1.107 2681
ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis
SIGNORiQ13574

Miscellaneous databases

ChiTaRSiDGKZ human
GeneWikiiDGKZ
GenomeRNAii8525
PROiPR:Q13574
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149091 Expressed in 102 organ(s), highest expression level in right frontal lobe
CleanExiHS_DGKZ
ExpressionAtlasiQ13574 baseline and differential
GenevisibleiQ13574 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
cd00029 C1, 1 hit
Gene3Di1.25.40.20, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00130 C1_1, 1 hit
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50146 DAGK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDGKZ_HUMAN
AccessioniPrimary (citable) accession number: Q13574
Secondary accession number(s): B7Z2M9
, B7Z6M3, E9PPW4, F6UCU9, G3V0F6, J3KNJ6, O00542, Q6ZVG7, Q8IVW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 187 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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