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Protein

Lysosomal-associated transmembrane protein 5

Gene

LAPTM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a special functional role during embryogenesis and in adult hematopoietic cells.1 Publication

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.74.1.4 the 4 tms multidrug endosomal transporter (met) family

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 5
Alternative name(s):
Lysosomal-associated multitransmembrane protein 5
Retinoic acid-inducible E3 protein
Gene namesi
Name:LAPTM5
Synonyms:KIAA0085
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162511.7
HGNCiHGNC:29612 LAPTM5
MIMi601476 gene
neXtProtiNX_Q13571

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7805
OpenTargetsiENSG00000162511
PharmGKBiPA134953439

Polymorphism and mutation databases

BioMutaiLAPTM5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843571 – 262Lysosomal-associated transmembrane protein 5Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei259PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13571
PaxDbiQ13571
PeptideAtlasiQ13571
PRIDEiQ13571
ProteomicsDBi59574

PTM databases

iPTMnetiQ13571
PhosphoSitePlusiQ13571
SwissPalmiQ13571

Expressioni

Tissue specificityi

Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues. Highly expressed in peripheral blood leukocytes, thymus, spleen and lung, followed by placenta, liver and kidney.1 Publication

Inductioni

By retinoic acid.

Gene expression databases

BgeeiENSG00000162511
CleanExiHS_LAPTM5
ExpressionAtlasiQ13571 baseline and differential
GenevisibleiQ13571 HS

Organism-specific databases

HPAiHPA051293

Interactioni

Subunit structurei

Binds to ubiquitin.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113580, 24 interactors
IntActiQ13571, 20 interactors
MINTiQ13571
STRINGi9606.ENSP00000294507

Structurei

3D structure databases

ProteinModelPortaliQ13571
SMRiQ13571
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi246 – 258Pro-richAdd BLAST13

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFZA Eukaryota
ENOG410YPPU LUCA
GeneTreeiENSGT00390000012862
HOGENOMiHOG000113282
HOVERGENiHBG052307
InParanoidiQ13571
KOiK12387
OMAiCVWRCYK
OrthoDBiEOG091G0JRF
PhylomeDBiQ13571
TreeFamiTF330843

Family and domain databases

InterProiView protein in InterPro
IPR004687 LAPTM4/5
IPR018396 LAPTM_4A/5
IPR018397 Lysosomal-assoc_TM_prot5
PANTHERiPTHR12479:SF2 PTHR12479:SF2, 3 hits
PfamiView protein in Pfam
PF03821 Mtp, 1 hit
TIGRFAMsiTIGR00799 mtp, 1 hit

Sequencei

Sequence statusi: Complete.

Q13571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC
60 70 80 90 100
KLSQMGYLRI ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI
110 120 130 140 150
MDYLLCLLTL LGSYIELPAY LKLASRSRAS SSKFPLMTLQ LLDFCLSILT
160 170 180 190 200
LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP HNQFIKMMII FSIAFITVLI
210 220 230 240 250
FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE EALSLPSKTP
260
EGGPAPPPYS EV
Length:262
Mass (Da):29,937
Last modified:November 1, 1996 - v1
Checksum:i64A9B3F09C14FCE7
GO

Sequence cautioni

The sequence BAA07643 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249T → D in AAA74018 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053653226R → K1 PublicationCorresponds to variant dbSNP:rs35351292Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51240 mRNA Translation: AAB08975.1
U30498 mRNA Translation: AAA74018.1
D42042 mRNA Translation: BAA07643.1 Different initiation.
BC106896 mRNA Translation: AAI06897.1
CCDSiCCDS337.1
PIRiG02476
RefSeqiNP_006753.1, NM_006762.2
UniGeneiHs.371021

Genome annotation databases

EnsembliENST00000294507; ENSP00000294507; ENSG00000162511
GeneIDi7805
KEGGihsa:7805

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLAPM5_HUMAN
AccessioniPrimary (citable) accession number: Q13571
Secondary accession number(s): Q13240, Q14698, Q3KP54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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