TDG

Functionⁱ

DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.7 Publications

Catalytic activityⁱ

Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.

GO - Molecular functionⁱ

ATP binding
Source: CAFA
Inferred from direct assayⁱ
- 11889051
chloride ion binding
Source: CAFA
Inferred from direct assayⁱ
- 15959518
damaged DNA binding
Source: ProtInc
Traceable author statementⁱ
- 9489705
DNA binding Source: UniProtKB
DNA N-glycosylase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21862836
- 22327402
double-stranded DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22327402
G/U mismatch-specific uracil-DNA glycosylase activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 18512959
magnesium ion binding
Source: CAFA
Inferred from direct assayⁱ
- 15959518
mismatched DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22573813
protein domain specific binding Source: Ensembl
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22327402
protein kinase C binding Source: Ensembl
protein self-association
Source: CAFA
Inferred from direct assayⁱ
- 18512959
pyrimidine-specific mismatch base pair DNA N-glycosylase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22573813
- 8662714
sodium ion binding
Source: CAFA
Inferred from direct assayⁱ
- 15959518
SUMO binding
Source: CAFA
Inferred from physical interactionⁱ
transcription coregulator activity Source: Ensembl
transcription factor binding Source: Ensembl
uracil DNA N-glycosylase activity
Source: CAFA
Inferred from direct assayⁱ
- 11889051

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

base-excision repair
Source: UniProtKB
Inferred from direct assayⁱ
- 21862836
- 22327402
base-excision repair, AP site formation
Source: CAFA
Inferred from direct assayⁱ
- 11889051
chromatin organization Source: UniProtKB-KW
depyrimidination Source: Reactome
DNA demethylation Source: UniProtKB
mismatch repair
Source: UniProtKB
Inferred from direct assayⁱ
- 22573813
negative regulation of chromatin binding Source: Ensembl
negative regulation of protein binding Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
oxidative DNA demethylation Source: Reactome
regulation of DNA N-glycosylase activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 18512959
regulation of embryonic development Source: UniProtKB
regulation of gene expression, epigenetic Source: UniProtKB
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Chromatin regulator, Hydrolase
Biological process	DNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

BRENDAⁱ	3.2.2.29 2681
Reactomeⁱ	R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110329 Cleavage of the damaged pyrimidine R-HSA-110357 Displacement of DNA glycosylase by APEX1 R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-5221030 TET1,2,3 and TDG demethylate DNA

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G/T mismatch-specific thymine DNA glycosylase (EC:3.2.2.29) Alternative name(s): Thymine-DNA glycosylase Short name: hTDG
Gene namesⁱ	Name:TDG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139372.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11700 TDG
MIMⁱ	601423 gene
neXtProtⁱ	NX_Q13569

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	140	N → A: Loss of DNA glycosylase activity but still able to bind DNA. 1 Publication	1
Mutagenesisⁱ	145	A → G: Increased DNA glycosylase activity on G/T mispairs. 1 Publication	1
Mutagenesisⁱ	151	H → A or Q: Increased DNA glycosylase activity on G/T mispairs. 1 Publication	1
Mutagenesisⁱ	191	N → A: Reduced DNA glycosylase activity on G/T and G/U mispairs. 1 Publication	1
Mutagenesisⁱ	197	T → A: Reduced DNA glycosylase activity on G/T mispairs. 1 Publication	1
Mutagenesisⁱ	281	R → A: Restores the DNA-binding ability of the sumoylated form. 1 Publication	1
Mutagenesisⁱ	310	E → Q: Restores the DNA-binding ability of the sumoylated form. 2 Publications	1
Mutagenesisⁱ	315	F → A: Restores the DNA-binding ability of the sumoylated form. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6996
Open Targets More...OpenTargetsⁱ	ENSG00000139372
PharmGKBⁱ	PA36419

Polymorphism and mutation databases

BioMutaⁱ	TDG
DMDMⁱ	46397791

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000185777	1 – 410	G/T mismatch-specific thymine DNA glycosylaseAdd BLAST		410

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Cross-linkⁱ	103	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	248	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	330	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linkⁱ	330	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Post-translational modificationⁱ

Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q13569
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13569
PaxDbⁱ	Q13569
PeptideAtlas More...PeptideAtlasⁱ	Q13569
PRIDEⁱ	Q13569
ProteomicsDBⁱ	59573

PTM databases

iPTMnetⁱ	Q13569
PhosphoSitePlusⁱ	Q13569

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000139372 Expressed in 233 organ(s), highest expression level in forebrain
CleanExⁱ	HS_TDG
ExpressionAtlasⁱ	Q13569 baseline and differential
Genevisibleⁱ	Q13569 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052263

HPAⁱ

HPA052263

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with AICDA and GADD45A.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AICDA	Q9GZX7	5	EBI-348333,EBI-3834328
GADD45A	P24522	3	EBI-348333,EBI-448167
Rnf4	O88846	2	EBI-348333,EBI-7258907	From Rattus norvegicus.

GO - Molecular functionⁱ

protein domain specific binding Source: Ensembl
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22327402
protein kinase C binding Source: Ensembl
protein self-association
Source: CAFA
Inferred from direct assayⁱ
- 18512959
SUMO binding
Source: CAFA
Inferred from physical interactionⁱ
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112855, 40 interactors
Database of interacting proteins More...DIPⁱ	DIP-32709N
ELMⁱ	Q13569
IntActⁱ	Q13569, 14 interactors
Molecular INTeraction database More...MINTⁱ	Q13569
STRINGⁱ	9606.ENSP00000376611

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	111 – 113	Combined sources	3
Helixⁱ	116 – 119	Combined sources	4
Beta strandⁱ	133 – 139	Combined sources	7
Helixⁱ	143 – 148	Combined sources	6
Beta strandⁱ	150 – 152	Combined sources	3
Beta strandⁱ	154 – 157	Combined sources	4
Helixⁱ	159 – 165	Combined sources	7
Beta strandⁱ	168 – 171	Combined sources	4
Helixⁱ	175 – 180	Combined sources	6
Helixⁱ	181 – 185	Combined sources	5
Beta strandⁱ	186 – 192	Combined sources	7
Helixⁱ	200 – 202	Combined sources	3
Helixⁱ	205 – 222	Combined sources	18
Beta strandⁱ	225 – 231	Combined sources	7
Helixⁱ	232 – 243	Combined sources	12
Beta strandⁱ	252 – 254	Combined sources	3
Beta strandⁱ	265 – 269	Combined sources	5
Beta strandⁱ	272 – 274	Combined sources	3
Beta strandⁱ	277 – 279	Combined sources	3
Helixⁱ	282 – 304	Combined sources	23
Beta strandⁱ	308 – 314	Combined sources	7
Helixⁱ	317 – 329	Combined sources	13

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00719
ProteinModelPortalⁱ	Q13569
SMRⁱ	Q13569
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13569

EvolutionaryTraceⁱ

Q13569

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4120 Eukaryota COG3663 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000987
HOGENOMⁱ	HOG000220820
HOVERGENⁱ	HBG003685
InParanoidⁱ	Q13569
KEGG Orthology (KO) More...KOⁱ	K20813
OMAⁱ	FPFQQMM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N58
PhylomeDBⁱ	Q13569
TreeFamⁱ	TF328764

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10028 UDG_F2_MUG, 1 hit
Gene3Dⁱ	3.40.470.10, 1 hit
InterProⁱ	View protein in InterPro IPR015637 MUG/TDG IPR003310 TDG IPR005122 Uracil-DNA_glycosylase-like IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERⁱ	PTHR12159 PTHR12159, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03167 UDG, 1 hit
SUPFAMⁱ	SSF52141 SSF52141, 1 hit
TIGRFAMsⁱ	TIGR00584 mug, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q13569-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEAENAGSYS LQQAQAFYTF PFQQLMAEAP NMAVVNEQQM PEEVPAPAPA 
        60         70         80         90        100
QEPVQEAPKG RKRKPRTTEP KQPVEPKKPV ESKKSGKSAK SKEKQEKITD 
       110        120        130        140        150
TFKVKRKVDR FNGVSEAELL TKTLPDILTF NLDIVIIGIN PGLMAAYKGH 
       160        170        180        190        200
HYPGPGNHFW KCLFMSGLSE VQLNHMDDHT LPGKYGIGFT NMVERTTPGS 
       210        220        230        240        250
KDLSSKEFRE GGRILVQKLQ KYQPRIAVFN GKCIYEIFSK EVFGVKVKNL 
       260        270        280        290        300
EFGLQPHKIP DTETLCYVMP SSSARCAQFP RAQDKVHYYI KLKDLRDQLK 
       310        320        330        340        350
GIERNMDVQE VQYTFDLQLA QEDAKKMAVK EEKYDPGYEA AYGGAYGENP 
       360        370        380        390        400
CSSEPCGFSS NGLIESVELR GESAFSGIPN GQWMTQSFTD QIPSFSNHCG 
       410
TQEQEEESHA

Length:410

Mass (Da):46,053

Last modified:April 13, 2004 - v2

Checksum:ⁱ33752B26EBC789AE

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B4E127	B4E127_HUMAN	G/T mismatch-specific thymine DNA g... G/T mismatch-specific thymine DNA glycosylase (cDNA FLJ50939, highly similar to G/T mismatch-specific thymine DNA glycosylase)	TDG	267	Annotation score:
G8JL98	G8JL98_HUMAN	G/T mismatch-specific thymine DNA g... G/T mismatch-specific thymine DNA glycosylase	TDG	406	Annotation score:
F5H0I7	F5H0I7_HUMAN	G/T mismatch-specific thymine DNA g... G/T mismatch-specific thymine DNA glycosylase	TDG	257	Annotation score:
H0YH18	H0YH18_HUMAN	G/T mismatch-specific thymine DNA g... G/T mismatch-specific thymine DNA glycosylase	TDG	111	Annotation score:
F5H539	F5H539_HUMAN	G/T mismatch-specific thymine DNA g... G/T mismatch-specific thymine DNA glycosylase	TDG	138	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	91	S → P in AAC50540 (PubMed:8662714).Curated		1
Sequence conflictⁱ	268	V → G in AAH37557 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018892	199	G → S1 PublicationCorresponds to variant dbSNP:rs4135113Ensembl.	1
Natural variantⁱVAR_059450	367	V → L. Corresponds to variant dbSNP:rs2888805Ensembl.	1
Natural variantⁱVAR_018893	367	V → M1 PublicationCorresponds to variant dbSNP:rs2888805Ensembl.	1
Natural variantⁱVAR_050140	381	G → E. Corresponds to variant dbSNP:rs3953597Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U51166 mRNA Translation: AAC50540.1 AF545435 Genomic DNA Translation: AAN16399.1 AC078819 Genomic DNA No translation available. BC037557 mRNA Translation: AAH37557.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9095.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003202.3, NM_003211.4
UniGeneⁱ	Hs.584809

Genome annotation databases

Ensemblⁱ	ENST00000392872; ENSP00000376611; ENSG00000139372
GeneIDⁱ	6996
KEGGⁱ	hsa:6996
UCSC genome browser More...UCSCⁱ	uc001tkg.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q13569	G/T mismatch-specific thymine DNA glycosylase (Fragment)		HUMAN		138	UniRef100_Q13569
G/T mismatch-specific thymine DNA glycosylase		HUMAN		267
UPI0008521CA0		HUMAN		227

Protein	Similar proteins		Species	Score	Length	Source
Q13569	G/T mismatch-specific thymine DNA glycosylase (Fragment)		HUMAN		138	UniRef90_Q13569
Uncharacterized protein		COLAP		410
Uncharacterized protein		PAPAN		410
G/T mismatch-specific thymine DNA glycosylase		CALJA		410
Thymine DNA glycosylase		GORGO		410
+105

Protein	Similar proteins		Species	Score	Length	Source
Q13569	G/T mismatch-specific thymine DNA glycosylase		MOUSE		421	UniRef50_Q13569
G/T mismatch-specific thymine DNA glycosylase (Fragment)		HUMAN		138
Uncharacterized protein		Cebus capucinus imitator		410
Uncharacterized protein		CERAT		410
G/T mismatch-specific thymine DNA glycosylase		CALJA		410
+458

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U51166 mRNA Translation: AAC50540.1 AF545435 Genomic DNA Translation: AAN16399.1 AC078819 Genomic DNA No translation available. BC037557 mRNA Translation: AAH37557.1
CCDSⁱ	CCDS9095.1
RefSeqⁱ	NP_003202.3, NM_003211.4
UniGeneⁱ	Hs.584809

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WYW	X-ray	2.10	A	112-339	[»]
	2D07	X-ray	2.10	A	112-339	[»]
	2RBA	X-ray	2.79	A/B	111-308	[»]
	3UFJ	X-ray	2.97	A/B	111-308	[»]
	3UO7	X-ray	3.00	A/B	111-308	[»]
	3UOB	X-ray	3.01	A/B	111-308	[»]
	4FNC	X-ray	2.49	A	111-308	[»]
	4JGC	X-ray	2.58	A	111-308	[»]
	4XEG	X-ray	1.72	A	111-308	[»]
	4Z3A	X-ray	1.72	A	111-308	[»]
	4Z47	X-ray	1.45	A	111-308	[»]
	4Z7B	X-ray	2.02	A	111-308	[»]
	4Z7Z	X-ray	1.83	A	111-308	[»]
	5CYS	X-ray	2.45	A	111-308	[»]
	5FF8	X-ray	1.70	A	82-308	[»]
	5HF7	X-ray	1.54	A	82-308	[»]
	5JXY	X-ray	1.71	A	111-308	[»]
	5T2W	X-ray	2.20	A	82-308	[»]
DisProtⁱ	DP00719
ProteinModelPortalⁱ	Q13569
SMRⁱ	Q13569
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112855, 40 interactors
DIPⁱ	DIP-32709N
ELMⁱ	Q13569
IntActⁱ	Q13569, 14 interactors
MINTⁱ	Q13569
STRINGⁱ	9606.ENSP00000376611

PTM databases

iPTMnetⁱ	Q13569
PhosphoSitePlusⁱ	Q13569

Polymorphism and mutation databases

BioMutaⁱ	TDG
DMDMⁱ	46397791

Proteomic databases

EPDⁱ	Q13569
MaxQBⁱ	Q13569
PaxDbⁱ	Q13569
PeptideAtlasⁱ	Q13569
PRIDEⁱ	Q13569
ProteomicsDBⁱ	59573

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000392872; ENSP00000376611; ENSG00000139372
GeneIDⁱ	6996
KEGGⁱ	hsa:6996
UCSCⁱ	uc001tkg.4 human

Organism-specific databases

CTDⁱ	6996
DisGeNETⁱ	6996
EuPathDBⁱ	HostDB:ENSG00000139372.14
GeneCardsⁱ	TDG
H-InvDBⁱ	HIX0026376
HGNCⁱ	HGNC:11700 TDG
HPAⁱ	HPA052263
MIMⁱ	601423 gene
neXtProtⁱ	NX_Q13569
OpenTargetsⁱ	ENSG00000139372
PharmGKBⁱ	PA36419
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4120 Eukaryota COG3663 LUCA
GeneTreeⁱ	ENSGT00390000000987
HOGENOMⁱ	HOG000220820
HOVERGENⁱ	HBG003685
InParanoidⁱ	Q13569
KOⁱ	K20813
OMAⁱ	FPFQQMM
OrthoDBⁱ	EOG091G0N58
PhylomeDBⁱ	Q13569
TreeFamⁱ	TF328764

Enzyme and pathway databases

BRENDAⁱ	3.2.2.29 2681
Reactomeⁱ	R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110329 Cleavage of the damaged pyrimidine R-HSA-110357 Displacement of DNA glycosylase by APEX1 R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-5221030 TET1,2,3 and TDG demethylate DNA

Miscellaneous databases

ChiTaRSⁱ	TDG human
EvolutionaryTraceⁱ	Q13569
GeneWikiⁱ	Thymine-DNA_glycosylase
GenomeRNAiⁱ	6996
Protein Ontology More...PROⁱ	PR:Q13569
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139372 Expressed in 233 organ(s), highest expression level in forebrain
CleanExⁱ	HS_TDG
ExpressionAtlasⁱ	Q13569 baseline and differential
Genevisibleⁱ	Q13569 HS

Family and domain databases

CDDⁱ	cd10028 UDG_F2_MUG, 1 hit
Gene3Dⁱ	3.40.470.10, 1 hit
InterProⁱ	View protein in InterPro IPR015637 MUG/TDG IPR003310 TDG IPR005122 Uracil-DNA_glycosylase-like IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERⁱ	PTHR12159 PTHR12159, 1 hit
Pfamⁱ	View protein in Pfam PF03167 UDG, 1 hit
SUPFAMⁱ	SSF52141 SSF52141, 1 hit
TIGRFAMsⁱ	TIGR00584 mug, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TDG_HUMAN
Accessionⁱ	Q13569Primary (citable) accession number: Q13569 Secondary accession number(s): Q8IUZ6, Q8IZM3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	April 13, 2004
	Last modified:	September 12, 2018
	This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q13569 (TDG_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

G/T mismatch-specific thymine DNA glycosylase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ