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UniProtKB - Q13568 (IRF5_HUMAN)

Entry version 182 (07 Apr 2021)
Sequence version 2 (16 Apr 2002)
Previous versions | rss
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Protein

Interferon regulatory factor 5

Gene

IRF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).By similarity6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Maintained as a monomer in an autoinhibited state (PubMed:25326418, PubMed:18836453, PubMed:22412986). Phosphorylation and activation follow the following steps: innate adapter protein TASL recruits IRF5, thereby licensing IRF5 for phosphorylation by IKBKB (PubMed:32433612). Phosphorylated IRF5 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs (PubMed:25326418, PubMed:32433612).4 Publications
(Microbial infection) Activated upon coronavirus SARS-CoV-2 infection.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi14 – 122IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST109

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processAntiviral defense, Immunity, Inflammatory response, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13568

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-877300, Interferon gamma signaling
R-HSA-909733, Interferon alpha/beta signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13568

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon regulatory factor 51 Publication
Short name:
IRF-51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRF51 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6120, IRF5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607218, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13568

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000128604.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Inflammatory bowel disease 14 (IBD14)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Related information in OMIM
Systemic lupus erythematosus 10 (SLEB10)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Related information in OMIM
Rheumatoid arthritis (RA)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionAn inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi446S → A: Abolished nuclear translocation. 1 Publication1

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

DisGeNET

More...DisGeNETi		3663

MalaCards human disease database

More...MalaCardsi		IRF5
MIMi180300, phenotype
612245, phenotype
612251, phenotype

Open Targets

More...OpenTargetsi		ENSG00000128604

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		220393, Diffuse cutaneous systemic sclerosis
220402, Limited cutaneous systemic sclerosis
206, NON RARE IN EUROPE: Crohn disease
771, NON RARE IN EUROPE: Ulcerative colitis
186, Primary biliary cholangitis
536, Systemic lupus erythematosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29919

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13568, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IRF5

Domain mapping of disease mutations (DMDM)

More...DMDMi		20178305

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001545581 – 498Interferon regulatory factor 5Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10Phosphothreonine1 Publication1
Modified residuei158Phosphoserine; by TBK11 Publication1
Modified residuei293Phosphoserine; by TBK11 Publication1
Modified residuei301Phosphoserine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki411Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei431PhosphoserineBy similarity1
Modified residuei435Phosphoserine2 Publications1
Modified residuei437Phosphoserine1 Publication1
Modified residuei440Phosphoserine1 Publication1
Modified residuei446Phosphoserine; by IKKB3 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of serine and threonine residues by IKBKB in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/EP300 and initiation of transcription.4 Publications
'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13568

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13568

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13568

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13568

PeptideAtlas

More...PeptideAtlasi		Q13568

PRoteomics IDEntifications database

More...PRIDEi		Q13568

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		18776
59569 [Q13568-1]
59570 [Q13568-2]
59571 [Q13568-3]
59572 [Q13568-4]
61205

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13568

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13568

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000128604, Expressed in monocyte and 184 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13568, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13568, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000128604, Tissue enhanced (ductus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, when phosphorylated (PubMed:25326418, PubMed:18836453).

Interacts with TASL (via pLxIS motif); interaction takes place downstream of TLR7, TLR8 or TLR9, leading to its activation (PubMed:32433612).

Interacts with MYD88 and TRAF6 (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109871, 36 interactors

Database of interacting proteins

More...DIPi		DIP-46348N

Protein interaction database and analysis system

More...IntActi		Q13568, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000349770

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13568, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1498
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13568

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13568

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi12 – 18Nuclear localization signal1 Publication7
Motifi150 – 160Nuclear export signal1 PublicationAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi142 – 149Poly-Glu8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSKM, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159926

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_031544_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13568

Identification of Orthologs from Complete Genome Data

More...OMAi		HHIWQAQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13568

TreeFam database of animal gene trees

More...TreeFami		TF328512

Family and domain databases

Conserved Domains Database

More...CDDi		cd00103, IRF, 1 hit

Database of protein disorder

More...DisProti		DP01907

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit
2.60.200.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00471

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019817, Interferon_reg_fac_CS
IPR001346, Interferon_reg_fact_DNA-bd_dom
IPR019471, Interferon_reg_factor-3
IPR029838, IRF5
IPR017855, SMAD-like_dom_sf
IPR008984, SMAD_FHA_dom_sf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR11949, PTHR11949, 1 hit
PTHR11949:SF10, PTHR11949:SF10, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00605, IRF, 1 hit
PF10401, IRF-3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00267, INTFRNREGFCT

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00348, IRF, 1 hit
SM01243, IRF-3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit
SSF49879, SSF49879, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00601, IRF_1, 1 hit
PS51507, IRF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13568-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA 
        60         70         80         90        100
TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF 
       110        120        130        140        150
RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL 
       160        170        180        190        200
QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ PPTLQPPVVL GPPAPDPSPL 
       210        220        230        240        250
APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL 
       260        270        280        290        300
EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP 
       310        320        330        340        350
SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC 
       360        370        380        390        400
ASAHDSCPNP IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG 
       410        420        430        440        450
EEWPDRKPRE KKLITVQVVP VAARLLLEMF SGELSWSADS IRLQISNPDL 
       460        470        480        490 
KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQ
Length:498
Mass (Da):56,044
Last modified:April 16, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01B2ED95C28384E8
GO
Isoform 2 (identifier: Q13568-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-160: T → TDAVQSGPHMTPYSLLK

Show »
Length:514
Mass (Da):57,770
Checksum:iD554D121D9E35893
GO
Isoform 3 (identifier: Q13568-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-175: EDVKWPPTLQPPTLR → DAVQSGPHMTPYSLLKEDVKW

Show »
Length:504
Mass (Da):56,669
Checksum:iA99FD4C058EC49C5
GO
Isoform 4 (identifier: Q13568-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-175: Missing.

Show »
Length:488
Mass (Da):54,943
Checksum:i4E43B54EE74A7E37
GO
Isoform 5 (identifier: Q13568-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-247: EDVKWPPTLQ...LLISPHMLPL → V

Show »
Length:412
Mass (Da):47,035
Checksum:i3519DC06A3230949
GO
Isoform 6 (identifier: Q13568-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-147: VCSNGPAPTDSQPPEDYSFGAGEEEEEE → TPSPLRITLLVQERRRKKRKSCRGCCQA
     148-498: Missing.

Show »
Length:147
Mass (Da):17,020
Checksum:iFEBD2F74E9F8AA38
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7M2C9J7M2_HUMAN
Interferon regulatory factor 5
IRF5
141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWA0A0A087WWA0_HUMAN
Interferon regulatory factor 5
IRF5
157Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYP7C9JYP7_HUMAN
Interferon regulatory factor 5
IRF5
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JB67C9JB67_HUMAN
Interferon regulatory factor 5
IRF5
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDH6F8WDH6_HUMAN
Interferon regulatory factor 5
IRF5
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2UM11A0A0G2UM11_HUMAN
Interferon regulatory factor 5
IRF5
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti253K → KK in AAU12880 (PubMed:15805103).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053330120 – 147VCSNG…EEEEE → TPSPLRITLLVQERRRKKRK SCRGCCQA in isoform 6. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_053331148 – 498Missing in isoform 6. 1 PublicationAdd BLAST351
Alternative sequenceiVSP_041375160T → TDAVQSGPHMTPYSLLK in isoform 2. 2 Publications1
Alternative sequenceiVSP_044822161 – 247EDVKW…HMLPL → V in isoform 5. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_043924161 – 175EDVKW…PPTLR → DAVQSGPHMTPYSLLKEDVK W in isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_043925166 – 175Missing in isoform 4. 3 Publications10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY504947 mRNA Translation: AAR90326.1
AY504946 mRNA Translation: AAR90325.1
AY693665 mRNA Translation: AAU12877.1
AY693666 mRNA Translation: AAU12878.1
AY693668 mRNA Translation: AAU12880.1
DQ277633 mRNA Translation: ABB88960.1
DQ277634 mRNA Translation: ABB88961.1
U51127 mRNA Translation: AAA96056.1
EF064718 Genomic DNA Translation: ABK41901.1
AC025594 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24107.1
CH236950 Genomic DNA Translation: EAL24108.1
CH471070 Genomic DNA Translation: EAW83703.1
CH471070 Genomic DNA Translation: EAW83705.1
BC004201 mRNA Translation: AAH04201.1
BC004139 mRNA Translation: AAH04139.1
DQ995495 Genomic DNA Translation: ABL96293.1
DQ995496 Genomic DNA Translation: ABL96294.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43645.1 [Q13568-2]
CCDS56512.1 [Q13568-5]
CCDS5808.1 [Q13568-1]

Protein sequence database of the Protein Information Resource

More...PIRi		G02474

NCBI Reference Sequences

More...RefSeqi		NP_001092097.2, NM_001098627.3 [Q13568-1]
NP_001092099.1, NM_001098629.2 [Q13568-2]
NP_001092100.1, NM_001098630.2 [Q13568-1]
NP_001229381.1, NM_001242452.2 [Q13568-5]
NP_001334857.1, NM_001347928.1 [Q13568-2]
NP_116032.1, NM_032643.4 [Q13568-1]
XP_005250374.1, XM_005250317.3
XP_006716037.1, XM_006715974.2 [Q13568-2]
XP_011514460.1, XM_011516158.2 [Q13568-2]
XP_011514461.1, XM_011516159.2 [Q13568-2]
XP_011514462.1, XM_011516160.1 [Q13568-2]
XP_011514463.1, XM_011516161.1
XP_011514464.1, XM_011516162.1
XP_011514465.1, XM_011516163.2
XP_011514466.1, XM_011516164.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000249375; ENSP00000249375; ENSG00000128604 [Q13568-1]
ENST00000357234; ENSP00000349770; ENSG00000128604 [Q13568-2]
ENST00000402030; ENSP00000385352; ENSG00000128604 [Q13568-1]
ENST00000465603; ENSP00000418534; ENSG00000128604 [Q13568-6]
ENST00000473745; ENSP00000419149; ENSG00000128604 [Q13568-1]
ENST00000477535; ENSP00000419950; ENSG00000128604 [Q13568-5]
ENST00000489702; ENSP00000418037; ENSG00000128604 [Q13568-2]
ENST00000619830; ENSP00000483292; ENSG00000128604 [Q13568-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3663

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3663

UCSC genome browser

More...UCSCi		uc003vog.4, human [Q13568-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY504947 mRNA Translation: AAR90326.1
AY504946 mRNA Translation: AAR90325.1
AY693665 mRNA Translation: AAU12877.1
AY693666 mRNA Translation: AAU12878.1
AY693668 mRNA Translation: AAU12880.1
DQ277633 mRNA Translation: ABB88960.1
DQ277634 mRNA Translation: ABB88961.1
U51127 mRNA Translation: AAA96056.1
EF064718 Genomic DNA Translation: ABK41901.1
AC025594 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24107.1
CH236950 Genomic DNA Translation: EAL24108.1
CH471070 Genomic DNA Translation: EAW83703.1
CH471070 Genomic DNA Translation: EAW83705.1
BC004201 mRNA Translation: AAH04201.1
BC004139 mRNA Translation: AAH04139.1
DQ995495 Genomic DNA Translation: ABL96293.1
DQ995496 Genomic DNA Translation: ABL96294.1
CCDSiCCDS43645.1 [Q13568-2]
CCDS56512.1 [Q13568-5]
CCDS5808.1 [Q13568-1]
PIRiG02474
RefSeqiNP_001092097.2, NM_001098627.3 [Q13568-1]
NP_001092099.1, NM_001098629.2 [Q13568-2]
NP_001092100.1, NM_001098630.2 [Q13568-1]
NP_001229381.1, NM_001242452.2 [Q13568-5]
NP_001334857.1, NM_001347928.1 [Q13568-2]
NP_116032.1, NM_032643.4 [Q13568-1]
XP_005250374.1, XM_005250317.3
XP_006716037.1, XM_006715974.2 [Q13568-2]
XP_011514460.1, XM_011516158.2 [Q13568-2]
XP_011514461.1, XM_011516159.2 [Q13568-2]
XP_011514462.1, XM_011516160.1 [Q13568-2]
XP_011514463.1, XM_011516161.1
XP_011514464.1, XM_011516162.1
XP_011514465.1, XM_011516163.2
XP_011514466.1, XM_011516164.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DSHX-ray2.00A232-477[»]
SMRiQ13568
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109871, 36 interactors
DIPiDIP-46348N
IntActiQ13568, 14 interactors
STRINGi9606.ENSP00000349770

PTM databases

iPTMnetiQ13568
PhosphoSitePlusiQ13568

Genetic variation databases

BioMutaiIRF5
DMDMi20178305

Proteomic databases

jPOSTiQ13568
MassIVEiQ13568
MaxQBiQ13568
PaxDbiQ13568
PeptideAtlasiQ13568
PRIDEiQ13568
ProteomicsDBi18776
59569 [Q13568-1]
59570 [Q13568-2]
59571 [Q13568-3]
59572 [Q13568-4]
61205

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17820, 601 antibodies

The DNASU plasmid repository

More...DNASUi		3663

Genome annotation databases

EnsembliENST00000249375; ENSP00000249375; ENSG00000128604 [Q13568-1]
ENST00000357234; ENSP00000349770; ENSG00000128604 [Q13568-2]
ENST00000402030; ENSP00000385352; ENSG00000128604 [Q13568-1]
ENST00000465603; ENSP00000418534; ENSG00000128604 [Q13568-6]
ENST00000473745; ENSP00000419149; ENSG00000128604 [Q13568-1]
ENST00000477535; ENSP00000419950; ENSG00000128604 [Q13568-5]
ENST00000489702; ENSP00000418037; ENSG00000128604 [Q13568-2]
ENST00000619830; ENSP00000483292; ENSG00000128604 [Q13568-6]
GeneIDi3663
KEGGihsa:3663
UCSCiuc003vog.4, human [Q13568-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3663
DisGeNETi3663

GeneCards: human genes, protein and diseases

More...GeneCardsi		IRF5
HGNCiHGNC:6120, IRF5
HPAiENSG00000128604, Tissue enhanced (ductus)
MalaCardsiIRF5
MIMi180300, phenotype
607218, gene
612245, phenotype
612251, phenotype
neXtProtiNX_Q13568
OpenTargetsiENSG00000128604
Orphaneti220393, Diffuse cutaneous systemic sclerosis
220402, Limited cutaneous systemic sclerosis
206, NON RARE IN EUROPE: Crohn disease
771, NON RARE IN EUROPE: Ulcerative colitis
186, Primary biliary cholangitis
536, Systemic lupus erythematosus
PharmGKBiPA29919
VEuPathDBiHostDB:ENSG00000128604.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSKM, Eukaryota
GeneTreeiENSGT00940000159926
HOGENOMiCLU_031544_0_1_1
InParanoidiQ13568
OMAiHHIWQAQ
PhylomeDBiQ13568
TreeFamiTF328512

Enzyme and pathway databases

PathwayCommonsiQ13568
ReactomeiR-HSA-877300, Interferon gamma signaling
R-HSA-909733, Interferon alpha/beta signaling
SIGNORiQ13568

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3663, 7 hits in 1010 CRISPR screens
EvolutionaryTraceiQ13568

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IRF5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3663
PharosiQ13568, Tbio

Protein Ontology

More...PROi		PR:Q13568
RNActiQ13568, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000128604, Expressed in monocyte and 184 other tissues
ExpressionAtlasiQ13568, baseline and differential
GenevisibleiQ13568, HS

Family and domain databases

CDDicd00103, IRF, 1 hit
DisProtiDP01907
Gene3Di1.10.10.10, 1 hit
2.60.200.10, 1 hit
IDEALiIID00471
InterProiView protein in InterPro
IPR019817, Interferon_reg_fac_CS
IPR001346, Interferon_reg_fact_DNA-bd_dom
IPR019471, Interferon_reg_factor-3
IPR029838, IRF5
IPR017855, SMAD-like_dom_sf
IPR008984, SMAD_FHA_dom_sf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PANTHERiPTHR11949, PTHR11949, 1 hit
PTHR11949:SF10, PTHR11949:SF10, 1 hit
PfamiView protein in Pfam
PF00605, IRF, 1 hit
PF10401, IRF-3, 1 hit
PRINTSiPR00267, INTFRNREGFCT
SMARTiView protein in SMART
SM00348, IRF, 1 hit
SM01243, IRF-3, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF49879, SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS00601, IRF_1, 1 hit
PS51507, IRF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRF5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13568
Secondary accession number(s): A4D1J8
, A8DUA8, A8DUA9, E7EQ16, E7EW54, Q1A7B4, Q64GA9, Q64GB1, Q64GB2, Q6RCM8, Q9BQF0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: April 7, 2021
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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