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Protein

Interferon regulatory factor 5

Gene

IRF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi14 – 122IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST109

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processAntiviral defense, Immunity, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
SIGNORiQ13568

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 5
Short name:
IRF-5
Gene namesi
Name:IRF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128604.18
HGNCiHGNC:6120 IRF5
MIMi607218 gene
neXtProtiNX_Q13568

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Inflammatory bowel disease 14 (IBD14)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
See also OMIM:612245
Systemic lupus erythematosus 10 (SLEB10)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
See also OMIM:612251
Rheumatoid arthritis (RA)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAn inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
See also OMIM:180300

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

DisGeNETi3663
MalaCardsiIRF5
MIMi180300 phenotype
612245 phenotype
612251 phenotype
OpenTargetsiENSG00000128604
Orphaneti220393 Diffuse cutaneous systemic sclerosis
220402 Limited cutaneous systemic sclerosis
206 NON RARE IN EUROPE: Crohn disease
536 NON RARE IN EUROPE: Systemic lupus erythematosus
771 NON RARE IN EUROPE: Ulcerative colitis
186 Primary biliary cholangitis
PharmGKBiPA29919

Polymorphism and mutation databases

BioMutaiIRF5
DMDMi20178305

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545581 – 498Interferon regulatory factor 5Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Phosphothreonine1 Publication1
Modified residuei158Phosphoserine; by TBK11 Publication1
Modified residuei293Phosphoserine; by TBK11 Publication1
Modified residuei301Phosphoserine1 Publication1
Cross-linki411Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei435Phosphoserine2 Publications1
Modified residuei437Phosphoserine1 Publication1
Modified residuei440Phosphoserine1 Publication1
Modified residuei446Phosphoserine2 Publications1

Post-translational modificationi

Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.2 Publications
'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ13568
PaxDbiQ13568
PeptideAtlasiQ13568
PRIDEiQ13568
ProteomicsDBi59569
59570 [Q13568-2]
59571 [Q13568-3]
59572 [Q13568-4]

PTM databases

iPTMnetiQ13568
PhosphoSitePlusiQ13568

Expressioni

Gene expression databases

BgeeiENSG00000128604 Expressed in 168 organ(s), highest expression level in cortex of kidney
CleanExiHS_IRF5
ExpressionAtlasiQ13568 baseline and differential
GenevisibleiQ13568 HS

Organism-specific databases

HPAiHPA046700

Interactioni

Subunit structurei

Homodimer, when phosphorylated.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109871, 34 interactors
DIPiDIP-46348N
IntActiQ13568, 13 interactors
STRINGi9606.ENSP00000349770

Structurei

Secondary structure

1498
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13568
SMRiQ13568
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13568

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 18Nuclear localization signal1 Publication7
Motifi150 – 160Nuclear export signalAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 149Poly-Glu8

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFCV Eukaryota
ENOG410XRXT LUCA
GeneTreeiENSGT00760000119093
HOGENOMiHOG000037433
HOVERGENiHBG105715
InParanoidiQ13568
KOiK09446
OMAiSHPNPIQ
PhylomeDBiQ13568
TreeFamiTF328512

Family and domain databases

CDDicd00103 IRF, 1 hit
Gene3Di1.10.10.10, 1 hit
2.60.200.10, 1 hit
InterProiView protein in InterPro
IPR019817 Interferon_reg_fac_CS
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR019471 Interferon_reg_factor-3
IPR029838 IRF5
IPR017855 SMAD-like_dom_sf
IPR008984 SMAD_FHA_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PTHR11949:SF10 PTHR11949:SF10, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PF10401 IRF-3, 1 hit
PRINTSiPR00267 INTFRNREGFCT
SMARTiView protein in SMART
SM00348 IRF, 1 hit
SM01243 IRF-3, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS00601 IRF_1, 1 hit
PS51507 IRF_2, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13568-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA
60 70 80 90 100
TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF
110 120 130 140 150
RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL
160 170 180 190 200
QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ PPTLQPPVVL GPPAPDPSPL
210 220 230 240 250
APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL
260 270 280 290 300
EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP
310 320 330 340 350
SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC
360 370 380 390 400
ASAHDSCPNP IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG
410 420 430 440 450
EEWPDRKPRE KKLITVQVVP VAARLLLEMF SGELSWSADS IRLQISNPDL
460 470 480 490
KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQ
Length:498
Mass (Da):56,044
Last modified:April 16, 2002 - v2
Checksum:i01B2ED95C28384E8
GO
Isoform 2 (identifier: Q13568-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-160: T → TDAVQSGPHMTPYSLLK

Show »
Length:514
Mass (Da):57,770
Checksum:iD554D121D9E35893
GO
Isoform 3 (identifier: Q13568-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-175: EDVKWPPTLQPPTLR → DAVQSGPHMTPYSLLKEDVKW

Show »
Length:504
Mass (Da):56,669
Checksum:iA99FD4C058EC49C5
GO
Isoform 4 (identifier: Q13568-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-175: Missing.

Show »
Length:488
Mass (Da):54,943
Checksum:i4E43B54EE74A7E37
GO
Isoform 5 (identifier: Q13568-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-247: EDVKWPPTLQ...LLISPHMLPL → V

Show »
Length:412
Mass (Da):47,035
Checksum:i3519DC06A3230949
GO
Isoform 6 (identifier: Q13568-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-147: VCSNGPAPTDSQPPEDYSFGAGEEEEEE → TPSPLRITLLVQERRRKKRKSCRGCCQA
     148-498: Missing.

Show »
Length:147
Mass (Da):17,020
Checksum:iFEBD2F74E9F8AA38
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAU6C9JAU6_HUMAN
Interferon regulatory factor 5
IRF5 hCG_40517
514Annotation score:
C9J7M2C9J7M2_HUMAN
Interferon regulatory factor 5
IRF5
141Annotation score:
C9JYP7C9JYP7_HUMAN
Interferon regulatory factor 5
IRF5
106Annotation score:
A0A087WWA0A0A087WWA0_HUMAN
Interferon regulatory factor 5
IRF5
157Annotation score:
F8WDH6F8WDH6_HUMAN
Interferon regulatory factor 5
IRF5
104Annotation score:
C9JB67C9JB67_HUMAN
Interferon regulatory factor 5
IRF5
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253K → KK in AAU12880 (PubMed:15805103).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053330120 – 147VCSNG…EEEEE → TPSPLRITLLVQERRRKKRK SCRGCCQA in isoform 6. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_053331148 – 498Missing in isoform 6. 1 PublicationAdd BLAST351
Alternative sequenceiVSP_041375160T → TDAVQSGPHMTPYSLLK in isoform 2. 2 Publications1
Alternative sequenceiVSP_044822161 – 247EDVKW…HMLPL → V in isoform 5. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_043924161 – 175EDVKW…PPTLR → DAVQSGPHMTPYSLLKEDVK W in isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_043925166 – 175Missing in isoform 4. 3 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY504947 mRNA Translation: AAR90326.1
AY504946 mRNA Translation: AAR90325.1
AY693665 mRNA Translation: AAU12877.1
AY693666 mRNA Translation: AAU12878.1
AY693668 mRNA Translation: AAU12880.1
DQ277633 mRNA Translation: ABB88960.1
DQ277634 mRNA Translation: ABB88961.1
U51127 mRNA Translation: AAA96056.1
EF064718 Genomic DNA Translation: ABK41901.1
AC025594 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24107.1
CH236950 Genomic DNA Translation: EAL24108.1
CH471070 Genomic DNA Translation: EAW83703.1
CH471070 Genomic DNA Translation: EAW83705.1
BC004201 mRNA Translation: AAH04201.1
BC004139 mRNA Translation: AAH04139.1
DQ995495 Genomic DNA Translation: ABL96293.1
DQ995496 Genomic DNA Translation: ABL96294.1
CCDSiCCDS43645.1 [Q13568-2]
CCDS56512.1 [Q13568-5]
CCDS5808.1 [Q13568-1]
PIRiG02474
RefSeqiNP_001092097.2, NM_001098627.3 [Q13568-1]
NP_001092099.1, NM_001098629.2 [Q13568-2]
NP_001092100.1, NM_001098630.2 [Q13568-1]
NP_001229381.1, NM_001242452.2 [Q13568-5]
NP_001334857.1, NM_001347928.1 [Q13568-2]
NP_116032.1, NM_032643.4 [Q13568-1]
XP_005250374.1, XM_005250317.3
XP_006716037.1, XM_006715974.2 [Q13568-2]
XP_011514460.1, XM_011516158.2 [Q13568-2]
XP_011514461.1, XM_011516159.2 [Q13568-2]
XP_011514462.1, XM_011516160.1 [Q13568-2]
XP_011514463.1, XM_011516161.1
XP_011514464.1, XM_011516162.1
XP_011514465.1, XM_011516163.2
XP_011514466.1, XM_011516164.1
UniGeneiHs.521181

Genome annotation databases

EnsembliENST00000249375; ENSP00000249375; ENSG00000128604 [Q13568-1]
ENST00000357234; ENSP00000349770; ENSG00000128604 [Q13568-2]
ENST00000402030; ENSP00000385352; ENSG00000128604 [Q13568-1]
ENST00000465603; ENSP00000418534; ENSG00000128604 [Q13568-6]
ENST00000473745; ENSP00000419149; ENSG00000128604 [Q13568-1]
ENST00000477535; ENSP00000419950; ENSG00000128604 [Q13568-5]
ENST00000489702; ENSP00000418037; ENSG00000128604 [Q13568-2]
ENST00000619830; ENSP00000483292; ENSG00000128604 [Q13568-6]
GeneIDi3663
KEGGihsa:3663
UCSCiuc003vog.4 human [Q13568-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY504947 mRNA Translation: AAR90326.1
AY504946 mRNA Translation: AAR90325.1
AY693665 mRNA Translation: AAU12877.1
AY693666 mRNA Translation: AAU12878.1
AY693668 mRNA Translation: AAU12880.1
DQ277633 mRNA Translation: ABB88960.1
DQ277634 mRNA Translation: ABB88961.1
U51127 mRNA Translation: AAA96056.1
EF064718 Genomic DNA Translation: ABK41901.1
AC025594 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24107.1
CH236950 Genomic DNA Translation: EAL24108.1
CH471070 Genomic DNA Translation: EAW83703.1
CH471070 Genomic DNA Translation: EAW83705.1
BC004201 mRNA Translation: AAH04201.1
BC004139 mRNA Translation: AAH04139.1
DQ995495 Genomic DNA Translation: ABL96293.1
DQ995496 Genomic DNA Translation: ABL96294.1
CCDSiCCDS43645.1 [Q13568-2]
CCDS56512.1 [Q13568-5]
CCDS5808.1 [Q13568-1]
PIRiG02474
RefSeqiNP_001092097.2, NM_001098627.3 [Q13568-1]
NP_001092099.1, NM_001098629.2 [Q13568-2]
NP_001092100.1, NM_001098630.2 [Q13568-1]
NP_001229381.1, NM_001242452.2 [Q13568-5]
NP_001334857.1, NM_001347928.1 [Q13568-2]
NP_116032.1, NM_032643.4 [Q13568-1]
XP_005250374.1, XM_005250317.3
XP_006716037.1, XM_006715974.2 [Q13568-2]
XP_011514460.1, XM_011516158.2 [Q13568-2]
XP_011514461.1, XM_011516159.2 [Q13568-2]
XP_011514462.1, XM_011516160.1 [Q13568-2]
XP_011514463.1, XM_011516161.1
XP_011514464.1, XM_011516162.1
XP_011514465.1, XM_011516163.2
XP_011514466.1, XM_011516164.1
UniGeneiHs.521181

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DSHX-ray2.00A232-477[»]
ProteinModelPortaliQ13568
SMRiQ13568
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109871, 34 interactors
DIPiDIP-46348N
IntActiQ13568, 13 interactors
STRINGi9606.ENSP00000349770

PTM databases

iPTMnetiQ13568
PhosphoSitePlusiQ13568

Polymorphism and mutation databases

BioMutaiIRF5
DMDMi20178305

Proteomic databases

MaxQBiQ13568
PaxDbiQ13568
PeptideAtlasiQ13568
PRIDEiQ13568
ProteomicsDBi59569
59570 [Q13568-2]
59571 [Q13568-3]
59572 [Q13568-4]

Protocols and materials databases

DNASUi3663
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249375; ENSP00000249375; ENSG00000128604 [Q13568-1]
ENST00000357234; ENSP00000349770; ENSG00000128604 [Q13568-2]
ENST00000402030; ENSP00000385352; ENSG00000128604 [Q13568-1]
ENST00000465603; ENSP00000418534; ENSG00000128604 [Q13568-6]
ENST00000473745; ENSP00000419149; ENSG00000128604 [Q13568-1]
ENST00000477535; ENSP00000419950; ENSG00000128604 [Q13568-5]
ENST00000489702; ENSP00000418037; ENSG00000128604 [Q13568-2]
ENST00000619830; ENSP00000483292; ENSG00000128604 [Q13568-6]
GeneIDi3663
KEGGihsa:3663
UCSCiuc003vog.4 human [Q13568-1]

Organism-specific databases

CTDi3663
DisGeNETi3663
EuPathDBiHostDB:ENSG00000128604.18
GeneCardsiIRF5
HGNCiHGNC:6120 IRF5
HPAiHPA046700
MalaCardsiIRF5
MIMi180300 phenotype
607218 gene
612245 phenotype
612251 phenotype
neXtProtiNX_Q13568
OpenTargetsiENSG00000128604
Orphaneti220393 Diffuse cutaneous systemic sclerosis
220402 Limited cutaneous systemic sclerosis
206 NON RARE IN EUROPE: Crohn disease
536 NON RARE IN EUROPE: Systemic lupus erythematosus
771 NON RARE IN EUROPE: Ulcerative colitis
186 Primary biliary cholangitis
PharmGKBiPA29919
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFCV Eukaryota
ENOG410XRXT LUCA
GeneTreeiENSGT00760000119093
HOGENOMiHOG000037433
HOVERGENiHBG105715
InParanoidiQ13568
KOiK09446
OMAiSHPNPIQ
PhylomeDBiQ13568
TreeFamiTF328512

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
SIGNORiQ13568

Miscellaneous databases

EvolutionaryTraceiQ13568
GeneWikiiIRF5
GenomeRNAii3663
PROiPR:Q13568
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128604 Expressed in 168 organ(s), highest expression level in cortex of kidney
CleanExiHS_IRF5
ExpressionAtlasiQ13568 baseline and differential
GenevisibleiQ13568 HS

Family and domain databases

CDDicd00103 IRF, 1 hit
Gene3Di1.10.10.10, 1 hit
2.60.200.10, 1 hit
InterProiView protein in InterPro
IPR019817 Interferon_reg_fac_CS
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR019471 Interferon_reg_factor-3
IPR029838 IRF5
IPR017855 SMAD-like_dom_sf
IPR008984 SMAD_FHA_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PTHR11949:SF10 PTHR11949:SF10, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PF10401 IRF-3, 1 hit
PRINTSiPR00267 INTFRNREGFCT
SMARTiView protein in SMART
SM00348 IRF, 1 hit
SM01243 IRF-3, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS00601 IRF_1, 1 hit
PS51507 IRF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIRF5_HUMAN
AccessioniPrimary (citable) accession number: Q13568
Secondary accession number(s): A4D1J8
, A8DUA8, A8DUA9, E7EQ16, E7EW54, Q1A7B4, Q64GA9, Q64GB1, Q64GB2, Q6RCM8, Q9BQF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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