UniProtKB - Q13557 (KCC2D_HUMAN)
Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK2D
Functioni
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca2+ release via direct phosphorylation of RYR2 Ca2+ channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca2+ influx to myocytes by binding and phosphorylating the L-type Ca2+ channel subunit beta-2 CACNB2. In addition to Ca2+ channels, can target and regulate the cardiac sarcolemmal Na+ channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca2+ uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca2+ transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
2 PublicationsMiscellaneous
Catalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 136 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 20 – 28 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: BHF-UCL
- calmodulin-dependent protein kinase activity Source: BHF-UCL
- identical protein binding Source: IntAct
- protein homodimerization activity Source: BHF-UCL
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: BHF-UCL
- protein serine kinase activity Source: RHEA
- sodium channel inhibitor activity Source: BHF-UCL
- titin binding Source: BHF-UCL
- transmembrane transporter binding Source: BHF-UCL
GO - Biological processi
- cardiac muscle cell contraction Source: BHF-UCL
- cellular response to calcium ion Source: BHF-UCL
- endoplasmic reticulum calcium ion homeostasis Source: BHF-UCL
- negative regulation of sodium ion transmembrane transport Source: BHF-UCL
- negative regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
- peptidyl-serine phosphorylation Source: BHF-UCL
- peptidyl-threonine phosphorylation Source: BHF-UCL
- positive regulation of cardiac muscle cell apoptotic process Source: BHF-UCL
- positive regulation of cardiac muscle hypertrophy Source: UniProtKB
- protein autophosphorylation Source: BHF-UCL
- protein phosphorylation Source: UniProtKB
- regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: BHF-UCL
- regulation of cardiac muscle cell action potential Source: BHF-UCL
- regulation of cardiac muscle cell action potential involved in regulation of contraction Source: BHF-UCL
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: UniProtKB
- regulation of cell communication by electrical coupling Source: BHF-UCL
- regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
- regulation of cell growth Source: UniProtKB
- regulation of cellular localization Source: UniProtKB
- regulation of heart contraction Source: UniProtKB
- regulation of heart rate by cardiac conduction Source: BHF-UCL
- regulation of histone deacetylase activity Source: BHF-UCL
- regulation of membrane depolarization Source: BHF-UCL
- regulation of relaxation of cardiac muscle Source: BHF-UCL
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
- regulation of ryanodine-sensitive calcium-release channel activity Source: UniProtKB
- regulation of the force of heart contraction Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: BHF-UCL
- relaxation of cardiac muscle Source: BHF-UCL
Keywordsi
Molecular function | Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.17, 2681 |
PathwayCommonsi | Q13557 |
Reactomei | R-HSA-111932, CaMK IV-mediated phosphorylation of CREB R-HSA-3371571, HSF1-dependent transactivation R-HSA-399719, Trafficking of AMPA receptors R-HSA-438066, Unblocking of NMDA receptors, glutamate binding and activation R-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor R-HSA-5576892, Phase 0 - rapid depolarisation R-HSA-5578775, Ion homeostasis R-HSA-5673000, RAF activation R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-877300, Interferon gamma signaling R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-936837, Ion transport by P-type ATPases R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors R-HSA-9617324, Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9620244, Long-term potentiation R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SignaLinki | Q13557 |
SIGNORi | Q13557 |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium/calmodulin-dependent protein kinase type II subunit delta (EC:2.7.11.17)Short name: CaM kinase II subunit delta Short name: CaMK-II subunit delta |
Gene namesi | Name:CAMK2D Synonyms:CAMKD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1462, CAMK2D |
MIMi | 607708, gene |
neXtProti | NX_Q13557 |
VEuPathDBi | HostDB:ENSG00000145349 |
Subcellular locationi
Plasma membrane
- sarcolemma Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated
Other locations
- Sarcoplasmic reticulum membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: BHF-UCL
Plasma Membrane
- sarcolemma Source: UniProtKB-SubCell
Other locations
- calcium- and calmodulin-dependent protein kinase complex Source: BHF-UCL
- cytoplasm Source: BHF-UCL
- endocytic vesicle membrane Source: Reactome
- membrane Source: UniProtKB
- neuron projection Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Membrane, Sarcoplasmic reticulumPathology & Biotechi
Organism-specific databases
DisGeNETi | 817 |
OpenTargetsi | ENSG00000145349 |
PharmGKBi | PA92 |
Miscellaneous databases
Pharosi | Q13557, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2801 |
DrugBanki | DB08039, (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE DB07853, 2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile DB12010, Fostamatinib |
DrugCentrali | Q13557 |
GuidetoPHARMACOLOGYi | 1558 |
Genetic variation databases
BioMutai | CAMK2D |
DMDMi | 116242602 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000086099 | 2 – 499 | Calcium/calmodulin-dependent protein kinase type II subunit deltaAdd BLAST | 498 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 287 | Phosphothreonine; by autocatalysis1 Publication | 1 | |
Modified residuei | 306 | Phosphothreonine; by autocatalysisCurated | 1 | |
Modified residuei | 307 | Phosphothreonine; by autocatalysisCurated | 1 | |
Modified residuei | 315 | PhosphoserineCombined sources | 1 | |
Modified residuei | 318 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 319 | PhosphoserineCombined sources | 1 | |
Modified residuei | 330 | PhosphoserineCombined sources | 1 | |
Modified residuei | 331 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 333 | PhosphoserineBy similarity | 1 | |
Modified residuei | 336 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 337 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 404 | PhosphoserineCombined sources | 1 | |
Modified residuei | 490 | PhosphoserineCombined sources | 1 | |
Modified residuei | 494 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q13557 |
jPOSTi | Q13557 |
MassIVEi | Q13557 |
MaxQBi | Q13557 |
PaxDbi | Q13557 |
PeptideAtlasi | Q13557 |
PRIDEi | Q13557 |
ProteomicsDBi | 59548 [Q13557-1] 59549 [Q13557-10] 59550 [Q13557-11] 59551 [Q13557-12] 59552 [Q13557-3] 59553 [Q13557-4] 59554 [Q13557-5] 59555 [Q13557-6] 59556 [Q13557-8] 59557 [Q13557-9] |
PTM databases
iPTMneti | Q13557 |
MetOSitei | Q13557 |
PhosphoSitePlusi | Q13557 |
SwissPalmi | Q13557 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000145349, Expressed in middle temporal gyrus and 213 other tissues |
ExpressionAtlasi | Q13557, baseline and differential |
Genevisiblei | Q13557, HS |
Organism-specific databases
HPAi | ENSG00000145349, Tissue enhanced (heart) |
Interactioni
Subunit structurei
CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (PubMed:14722083).
Interacts with RRAD and CACNB2 (By similarity).
By similarity1 PublicationBinary interactionsi
Q13557
Isoform Delta 6 [Q13557-8]
GO - Molecular functioni
- calmodulin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- protein homodimerization activity Source: BHF-UCL
- titin binding Source: BHF-UCL
- transmembrane transporter binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107267, 138 interactors |
CORUMi | Q13557 |
DIPi | DIP-33129N |
IntActi | Q13557, 150 interactors |
MINTi | Q13557 |
STRINGi | 9606.ENSP00000339740 |
Chemistry databases
BindingDBi | Q13557 |
Miscellaneous databases
RNActi | Q13557, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13557 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13557 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 272 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 283 – 292 | Autoinhibitory domainBy similarity | 10 | |
Regioni | 291 – 301 | Calmodulin-bindingBy similarityAdd BLAST | 11 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0033, Eukaryota |
GeneTreei | ENSGT00940000155150 |
HOGENOMi | CLU_000288_71_0_1 |
InParanoidi | Q13557 |
PhylomeDBi | Q13557 |
TreeFami | TF315229 |
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR032710, NTF2-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54427, SSF54427, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (10+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 10 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 10 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL
60 70 80 90 100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE
110 120 130 140 150
DIVAREYYSE ADASHCIQQI LESVNHCHLN GIVHRDLKPE NLLLASKSKG
160 170 180 190 200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC
210 220 230 240 250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN
260 270 280 290 300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL
310 320 330 340 350
KGAILTTMLA TRNFSAAKSL LKKPDGVKES TESSNTTIED EDVKARKQEI
360 370 380 390 400
IKVTEQLIEA INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE
410 420 430 440 450
NALSKSNKPI HTIILNPHVH LVGDDAACIA YIRLTQYMDG SGMPKTMQSE
460 470 480 490
ETRVWHRRDG KWQNVHFHRS GSPTVPIKPP CIPNGKENFS GGTSLWQNI
The sequence of this isoform differs from the canonical sequence as follows:
328-328: K → KKRKSSSSVQMM
The sequence of this isoform differs from the canonical sequence as follows:
328-328: K → KINNKANVVTSPKENIPTPAL
The sequence of this isoform differs from the canonical sequence as follows:
479-499: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
328-328: K → KKRKSSSSVQMM
479-499: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
328-328: K → KINNKANVVTSPKENIPTPAL
479-499: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
329-329: E → EPQTTVIHNPDGNKE
The sequence of this isoform differs from the canonical sequence as follows:
329-329: E → EPQTTVIHNPDGNKE
479-499: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
328-328: K → KKRKSSSSVQMMEPQTTVIHNPDGNK
The sequence of this isoform differs from the canonical sequence as follows:
478-478: K → N
479-499: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PF82 | E9PF82_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2D | 533 | Annotation score: | ||
E9PBG7 | E9PBG7_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2D | 512 | Annotation score: | ||
D6R938 | D6R938_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2D hCG_22679 | 498 | Annotation score: | ||
H0Y9C2 | H0Y9C2_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2D | 194 | Annotation score: | ||
H0Y9J2 | H0Y9J2_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2D | 182 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 39 | E → G in AAD20442 (PubMed:10189359).Curated | 1 | |
Sequence conflicti | 272 | I → T in AAX88806 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040602 | 167 | D → E1 PublicationCorresponds to variant dbSNP:rs35367671EnsemblClinVar. | 1 | |
Natural variantiVAR_028196 | 463 | Q → E. Corresponds to variant dbSNP:rs1053668Ensembl. | 1 | |
Natural variantiVAR_040603 | 493 | T → I1 PublicationCorresponds to variant dbSNP:rs35765784Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023095 | 328 | K → KKRKSSSSVQMMEPQTTVIH NPDGNK in isoform Delta 11. Curated | 1 | |
Alternative sequenceiVSP_023096 | 328 | K → KKRKSSSSVQMM in isoform Delta 3 and isoform Delta 7. 1 Publication | 1 | |
Alternative sequenceiVSP_023097 | 328 | K → KINNKANVVTSPKENIPTPA L in isoform Delta 4 and isoform Delta 8. Curated | 1 | |
Alternative sequenceiVSP_023098 | 329 | E → EPQTTVIHNPDGNKE in isoform Delta 9 and isoform Delta 10. 1 Publication | 1 | |
Alternative sequenceiVSP_041820 | 478 | K → N in isoform Delta 12. 1 Publication | 1 | |
Alternative sequenceiVSP_023099 | 479 – 499 | Missing in isoform Delta 6, isoform Delta 7, isoform Delta 8, isoform Delta 10 and isoform Delta 12. 4 PublicationsAdd BLAST | 21 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VN9 | X-ray | 2.30 | A/B | 11-309 | [»] | |
2W2C | X-ray | 2.70 | A/B/C/D/E/F/G/H/I/J/K/L/M/N | 334-475 | [»] | |
2WEL | X-ray | 1.90 | A | 11-335 | [»] | |
3GP2 | X-ray | 1.46 | B | 294-311 | [»] | |
5VLO | X-ray | 2.05 | A/B | 3-301 | [»] | |
6AYW | X-ray | 2.05 | A/B | 3-301 | [»] | |
SMRi | Q13557 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107267, 138 interactors |
CORUMi | Q13557 |
DIPi | DIP-33129N |
IntActi | Q13557, 150 interactors |
MINTi | Q13557 |
STRINGi | 9606.ENSP00000339740 |
Chemistry databases
BindingDBi | Q13557 |
ChEMBLi | CHEMBL2801 |
DrugBanki | DB08039, (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE DB07853, 2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile DB12010, Fostamatinib |
DrugCentrali | Q13557 |
GuidetoPHARMACOLOGYi | 1558 |
PTM databases
iPTMneti | Q13557 |
MetOSitei | Q13557 |
PhosphoSitePlusi | Q13557 |
SwissPalmi | Q13557 |
Genetic variation databases
BioMutai | CAMK2D |
DMDMi | 116242602 |
Proteomic databases
EPDi | Q13557 |
jPOSTi | Q13557 |
MassIVEi | Q13557 |
MaxQBi | Q13557 |
PaxDbi | Q13557 |
PeptideAtlasi | Q13557 |
PRIDEi | Q13557 |
ProteomicsDBi | 59548 [Q13557-1] 59549 [Q13557-10] 59550 [Q13557-11] 59551 [Q13557-12] 59552 [Q13557-3] 59553 [Q13557-4] 59554 [Q13557-5] 59555 [Q13557-6] 59556 [Q13557-8] 59557 [Q13557-9] |
Protocols and materials databases
Antibodypediai | 15593, 341 antibodies from 35 providers |
DNASUi | 817 |
Genome annotation databases
Organism-specific databases
CTDi | 817 |
DisGeNETi | 817 |
GeneCardsi | CAMK2D |
HGNCi | HGNC:1462, CAMK2D |
HPAi | ENSG00000145349, Tissue enhanced (heart) |
MIMi | 607708, gene |
neXtProti | NX_Q13557 |
OpenTargetsi | ENSG00000145349 |
PharmGKBi | PA92 |
VEuPathDBi | HostDB:ENSG00000145349 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0033, Eukaryota |
GeneTreei | ENSGT00940000155150 |
HOGENOMi | CLU_000288_71_0_1 |
InParanoidi | Q13557 |
PhylomeDBi | Q13557 |
TreeFami | TF315229 |
Enzyme and pathway databases
BRENDAi | 2.7.11.17, 2681 |
PathwayCommonsi | Q13557 |
Reactomei | R-HSA-111932, CaMK IV-mediated phosphorylation of CREB R-HSA-3371571, HSF1-dependent transactivation R-HSA-399719, Trafficking of AMPA receptors R-HSA-438066, Unblocking of NMDA receptors, glutamate binding and activation R-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor R-HSA-5576892, Phase 0 - rapid depolarisation R-HSA-5578775, Ion homeostasis R-HSA-5673000, RAF activation R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-877300, Interferon gamma signaling R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-936837, Ion transport by P-type ATPases R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors R-HSA-9617324, Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9620244, Long-term potentiation R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SignaLinki | Q13557 |
SIGNORi | Q13557 |
Miscellaneous databases
BioGRID-ORCSi | 817, 9 hits in 1071 CRISPR screens |
ChiTaRSi | CAMK2D, human |
EvolutionaryTracei | Q13557 |
GeneWikii | CAMK2D |
GenomeRNAii | 817 |
Pharosi | Q13557, Tchem |
PROi | PR:Q13557 |
RNActi | Q13557, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145349, Expressed in middle temporal gyrus and 213 other tissues |
ExpressionAtlasi | Q13557, baseline and differential |
Genevisiblei | Q13557, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR032710, NTF2-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54427, SSF54427, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KCC2D_HUMAN | |
Accessioni | Q13557Primary (citable) accession number: Q13557 Secondary accession number(s): A8MVS8 Q9UQE9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 23, 2022 | |
This is version 221 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families