Calcium/calmodulin-dependent protein kinase type II subunit delta

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• calmodulin binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 20668654
• calmodulin-dependent protein kinase activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 22514276
  • 23283722
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • 20668654
  • 25416956
• ion channel binding Source: BHF-UCLInferred from physical interactionⁱ
  • 22514276
• protein homodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • 20668654
• protein serine/threonine kinase activity Source: BHF-UCLInferred from direct assayⁱ
  • 22514276
• Ras guanyl-nucleotide exchange factor activity Source: Reactome
• sodium channel inhibitor activity Source: BHF-UCLInferred from direct assayⁱ
  • 22514276
• titin binding Source: BHF-UCLInferred from physical interactionⁱ
  • 23283722

GO - Biological processⁱ

• cardiac muscle cell contraction Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • 12676814
• cellular response to calcium ion Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 23283722
• endoplasmic reticulum calcium ion homeostasis Source: BHF-UCL
• interferon-gamma-mediated signaling pathway Source: Reactome
• MAPK cascade Source: Reactome
• negative regulation of sodium ion transmembrane transport Source: BHF-UCLInferred from direct assayⁱ
  • 22514276
• negative regulation of sodium ion transmembrane transporter activity Source: BHF-UCLInferred from direct assayⁱ
  • 22514276
• peptidyl-serine phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • 22514276
  • 23283722
• peptidyl-threonine phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • 22514276
  • 23283722
• positive regulation of cardiac muscle cell apoptotic process Source: BHF-UCL
• positive regulation of cardiac muscle hypertrophy Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 17179159
• protein autophosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • 22514276
• protein complex oligomerization Source: BHF-UCLInferred from direct assayⁱ
  • 20668654
• protein phosphorylation Source: UniProtKBInferred from direct assayⁱ
  • 17179159
• regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: BHF-UCL
• regulation of cardiac muscle cell action potential Source: BHF-UCL
• regulation of cardiac muscle cell action potential involved in regulation of contraction Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • 12676813
• regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: UniProtKBTraceable author statementⁱ
  • 17157285
• regulation of cell communication by electrical coupling Source: BHF-UCL
• regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCLInferred by curatorⁱ
  • 12676813
• regulation of cell growth Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 9060999
• regulation of cellular localization Source: UniProtKBInferred from mutant phenotypeⁱ
  • 17179159
• regulation of heart contraction Source: UniProtKBTraceable author statementⁱ
  • 17157285
• regulation of heart rate by cardiac conduction Source: BHF-UCLInferred by curatorⁱ
  • 22514276
• regulation of histone deacetylase activity Source: BHF-UCLTraceable author statementⁱ
  • 23283722
• regulation of membrane depolarization Source: BHF-UCLInferred from direct assayⁱ
  • 22514276
• regulation of relaxation of cardiac muscle Source: BHF-UCLInferred from direct assayⁱ
  • 23283722
• regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
• regulation of ryanodine-sensitive calcium-release channel activity Source: UniProtKBTraceable author statementⁱ
  • 19482609
• regulation of the force of heart contraction Source: BHF-UCLTraceable author statementⁱ
  • 23283722
• regulation of transcription by RNA polymerase II Source: BHF-UCLTraceable author statementⁱ
  • 23283722
• relaxation of cardiac muscle Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • 12676814

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• calmodulin binding Source: BHF-UCLInferred from physical interactionⁱ
  • 20668654
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • 20668654
  • 25416956
• ion channel binding Source: BHF-UCLInferred from physical interactionⁱ
  • 22514276
• protein homodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • 20668654
• Ras guanyl-nucleotide exchange factor activity Source: Reactome
• titin binding Source: BHF-UCLInferred from physical interactionⁱ
  • 23283722

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 10 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL 
        60         70         80         90        100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE 
       110        120        130        140        150
DIVAREYYSE ADASHCIQQI LESVNHCHLN GIVHRDLKPE NLLLASKSKG 
       160        170        180        190        200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC 
       210        220        230        240        250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN 
       260        270        280        290        300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 
       310        320        330        340        350
KGAILTTMLA TRNFSAAKSL LKKPDGVKES TESSNTTIED EDVKARKQEI 
       360        370        380        390        400
IKVTEQLIEA INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE 
       410        420        430        440        450
NALSKSNKPI HTIILNPHVH LVGDDAACIA YIRLTQYMDG SGMPKTMQSE 
       460        470        480        490 
ETRVWHRRDG KWQNVHFHRS GSPTVPIKPP CIPNGKENFS GGTSLWQNI  

        10         20         30         40         50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL 
        60         70         80         90        100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE 
       110        120        130        140        150
DIVAREYYSE ADASHCIQQI LESVNHCHLN GIVHRDLKPE NLLLASKSKG 
       160        170        180        190        200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC 
       210        220        230        240        250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN 
       260        270        280        290        300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 
       310        320        330        340        350
KGAILTTMLA TRNFSAAKSL LKKPDGVKKR KSSSSVQMME STESSNTTIE 
       360        370        380        390        400
DEDVKARKQE IIKVTEQLIE AINNGDFEAY TKICDPGLTA FEPEALGNLV 
       410        420        430        440        450
EGMDFHRFYF ENALSKSNKP IHTIILNPHV HLVGDDAACI AYIRLTQYMD 
       460        470        480        490        500
GSGMPKTMQS EETRVWHRRD GKWQNVHFHR SGSPTVPIKP PCIPNGKENF 
       510
SGGTSLWQNI                                             

        10         20         30         40         50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL 
        60         70         80         90        100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE 
       110        120        130        140        150
DIVAREYYSE ADASHCIQQI LESVNHCHLN GIVHRDLKPE NLLLASKSKG 
       160        170        180        190        200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC 
       210        220        230        240        250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN 
       260        270        280        290        300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 
       310        320        330        340        350
KGAILTTMLA TRNFSAAKSL LKKPDGVKIN NKANVVTSPK ENIPTPALES 
       360        370        380        390        400
TESSNTTIED EDVKARKQEI IKVTEQLIEA INNGDFEAYT KICDPGLTAF 
       410        420        430        440        450
EPEALGNLVE GMDFHRFYFE NALSKSNKPI HTIILNPHVH LVGDDAACIA 
       460        470        480        490        500
YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS GSPTVPIKPP 
       510 
CIPNGKENFS GGTSLWQNI                                   

        10         20         30         40         50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL 
        60         70         80         90        100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE 
       110        120        130        140        150
DIVAREYYSE ADASHCIQQI LESVNHCHLN GIVHRDLKPE NLLLASKSKG 
       160        170        180        190        200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC 
       210        220        230        240        250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN 
       260        270        280        290        300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 
       310        320        330        340        350
KGAILTTMLA TRNFSAAKSL LKKPDGVKES TESSNTTIED EDVKARKQEI 
       360        370        380        390        400
IKVTEQLIEA INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE 
       410        420        430        440        450
NALSKSNKPI HTIILNPHVH LVGDDAACIA YIRLTQYMDG SGMPKTMQSE 
       460        470 
ETRVWHRRDG KWQNVHFHRS GSPTVPIK                         

        10         20         30         40         50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL 
        60         70         80         90        100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE 
       110        120        130        140        150
DIVAREYYSE ADASHCIQQI LESVNHCHLN GIVHRDLKPE NLLLASKSKG 
       160        170        180        190        200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC 
       210        220        230        240        250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN 
       260        270        280        290        300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 
       310        320        330        340        350
KGAILTTMLA TRNFSAAKSL LKKPDGVKKR KSSSSVQMME STESSNTTIE 
       360        370        380        390        400
DEDVKARKQE IIKVTEQLIE AINNGDFEAY TKICDPGLTA FEPEALGNLV 
       410        420        430        440        450
EGMDFHRFYF ENALSKSNKP IHTIILNPHV HLVGDDAACI AYIRLTQYMD 
       460        470        480 
GSGMPKTMQS EETRVWHRRD GKWQNVHFHR SGSPTVPIK             

        10         20         30         40         50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL 
        60         70         80         90        100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE 
       110        120        130        140        150
DIVAREYYSE ADASHCIQQI LESVNHCHLN GIVHRDLKPE NLLLASKSKG 
       160        170        180        190        200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC 
       210        220        230        240        250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN 
       260        270        280        290        300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 
       310        320        330        340        350
KGAILTTMLA TRNFSAAKSL LKKPDGVKIN NKANVVTSPK ENIPTPALES 
       360        370        380        390        400
TESSNTTIED EDVKARKQEI IKVTEQLIEA INNGDFEAYT KICDPGLTAF 
       410        420        430        440        450
EPEALGNLVE GMDFHRFYFE NALSKSNKPI HTIILNPHVH LVGDDAACIA 
       460        470        480        490 
YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS GSPTVPIK   

        10         20         30         40         50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL 
        60         70         80         90        100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE 
       110        120        130        140        150
DIVAREYYSE ADASHCIQQI LESVNHCHLN GIVHRDLKPE NLLLASKSKG 
       160        170        180        190        200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC 
       210        220        230        240        250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN 
       260        270        280        290        300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 
       310        320        330        340        350
KGAILTTMLA TRNFSAAKSL LKKPDGVKEP QTTVIHNPDG NKESTESSNT 
       360        370        380        390        400
TIEDEDVKAR KQEIIKVTEQ LIEAINNGDF EAYTKICDPG LTAFEPEALG 
       410        420        430        440        450
NLVEGMDFHR FYFENALSKS NKPIHTIILN PHVHLVGDDA ACIAYIRLTQ 
       460        470        480        490        500
YMDGSGMPKT MQSEETRVWH RRDGKWQNVH FHRSGSPTVP IKPPCIPNGK 
       510 
ENFSGGTSLW QNI                                         

        10         20         30         40         50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL 
        60         70         80         90        100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE 
       110        120        130        140        150
DIVAREYYSE ADASHCIQQI LESVNHCHLN GIVHRDLKPE NLLLASKSKG 
       160        170        180        190        200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC 
       210        220        230        240        250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN 
       260        270        280        290        300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 
       310        320        330        340        350
KGAILTTMLA TRNFSAAKSL LKKPDGVKEP QTTVIHNPDG NKESTESSNT 
       360        370        380        390        400
TIEDEDVKAR KQEIIKVTEQ LIEAINNGDF EAYTKICDPG LTAFEPEALG 
       410        420        430        440        450
NLVEGMDFHR FYFENALSKS NKPIHTIILN PHVHLVGDDA ACIAYIRLTQ 
       460        470        480        490 
YMDGSGMPKT MQSEETRVWH RRDGKWQNVH FHRSGSPTVP IK         

        10         20         30         40         50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL 
        60         70         80         90        100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE 
       110        120        130        140        150
DIVAREYYSE ADASHCIQQI LESVNHCHLN GIVHRDLKPE NLLLASKSKG 
       160        170        180        190        200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC 
       210        220        230        240        250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN 
       260        270        280        290        300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 
       310        320        330        340        350
KGAILTTMLA TRNFSAAKSL LKKPDGVKKR KSSSSVQMME PQTTVIHNPD 
       360        370        380        390        400
GNKESTESSN TTIEDEDVKA RKQEIIKVTE QLIEAINNGD FEAYTKICDP 
       410        420        430        440        450
GLTAFEPEAL GNLVEGMDFH RFYFENALSK SNKPIHTIIL NPHVHLVGDD 
       460        470        480        490        500
AACIAYIRLT QYMDGSGMPK TMQSEETRVW HRRDGKWQNV HFHRSGSPTV 
       510        520 
PIKPPCIPNG KENFSGGTSL WQNI                             

        10         20         30         40         50
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL 
        60         70         80         90        100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE 
       110        120        130        140        150
DIVAREYYSE ADASHCIQQI LESVNHCHLN GIVHRDLKPE NLLLASKSKG 
       160        170        180        190        200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKDP YGKPVDMWAC 
       210        220        230        240        250
GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN 
       260        270        280        290        300
KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 
       310        320        330        340        350
KGAILTTMLA TRNFSAAKSL LKKPDGVKES TESSNTTIED EDVKARKQEI 
       360        370        380        390        400
IKVTEQLIEA INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE 
       410        420        430        440        450
NALSKSNKPI HTIILNPHVH LVGDDAACIA YIRLTQYMDG SGMPKTMQSE 
       460        470 
ETRVWHRRDG KWQNVHFHRS GSPTVPIN                         

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases