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Protein

Calcium/calmodulin-dependent protein kinase type II subunit gamma

Gene

CAMK2G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca2+ transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by Ca2+/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca2+-independent activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei43ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi20 – 28ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.17 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5578775 Ion homeostasis
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-877300 Interferon gamma signaling
R-HSA-9022692 Regulation of MECP2 expression and activity
R-HSA-936837 Ion transport by P-type ATPases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q13555

SIGNOR Signaling Network Open Resource

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SIGNORi
Q13555

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type II subunit gamma (EC:2.7.11.17)
Short name:
CaM kinase II subunit gamma
Short name:
CaMK-II subunit gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAMK2G
Synonyms:CAMK, CAMK-II, CAMKG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000148660.20

Human Gene Nomenclature Database

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HGNCi
HGNC:1463 CAMK2G

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602123 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13555

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
818

Open Targets

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OpenTargetsi
ENSG00000148660

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA93

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3829

Drug and drug target database

More...
DrugBanki
DB06616 Bosutinib

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1557

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CAMK2G

Domain mapping of disease mutations (DMDM)

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DMDMi
62512173

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000861011 – 558Calcium/calmodulin-dependent protein kinase type II subunit gammaAdd BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei287Phosphothreonine; by autocatalysisCombined sources1 Publication1
Modified residuei306Phosphothreonine; by autocatalysisBy similarity1
Modified residuei307Phosphothreonine; by autocatalysisCurated1
Modified residuei311PhosphoserineCombined sources1
Modified residuei334PhosphoserineBy similarity1
Modified residuei349PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1
Modified residuei484PhosphoserineBy similarity1
Isoform 2 (identifier: Q13555-2)
Modified residuei325PhosphoserineCombined sources1
Isoform 3 (identifier: Q13555-3)
Modified residuei325PhosphoserineCombined sources1
Isoform 5 (identifier: Q13555-5)
Modified residuei325PhosphoserineCombined sources1
Isoform 6 (identifier: Q13555-6)
Modified residuei325PhosphoserineCombined sources1
Isoform 7 (identifier: Q13555-7)
Modified residuei325PhosphoserineCombined sources1
Isoform 8 (identifier: Q13555-8)
Modified residuei325PhosphoserineCombined sources1
Isoform 9 (identifier: Q13555-9)
Modified residuei325PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Isoform 10 (identifier: Q13555-10)
Modified residuei325PhosphoserineCombined sources1
Isoform 11 (identifier: Q13555-11)
Modified residuei325PhosphoserineCombined sources1
Modified residuei346PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylation of Thr-287 following activation by Ca2+/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13555

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13555

PeptideAtlas

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PeptideAtlasi
Q13555

PRoteomics IDEntifications database

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PRIDEi
Q13555

ProteomicsDB human proteome resource

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ProteomicsDBi
59538
59539 [Q13555-10]
59540 [Q13555-2]
59541 [Q13555-3]
59542 [Q13555-4]
59543 [Q13555-5]
59544 [Q13555-6]
59545 [Q13555-7]
59546 [Q13555-8]
59547 [Q13555-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13555

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13555

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Activity is induced in skeletal muscle during exercise.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148660 Expressed in 223 organ(s), highest expression level in lower esophagus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13555 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13555 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040656
HPA051783
HPA051785
HPA053973

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107268, 51 interactors

Database of interacting proteins

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DIPi
DIP-51315N

Protein interaction database and analysis system

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IntActi
Q13555, 43 interactors

Molecular INTeraction database

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MINTi
Q13555

STRING: functional protein association networks

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STRINGi
9606.ENSP00000319060

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q13555

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1558
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13555

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13555

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q13555

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 272Protein kinasePROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni283 – 292Autoinhibitory domain10
Regioni291 – 301Calmodulin-bindingBy similarityAdd BLAST11
Regioni294 – 316Calmodulin-bindingAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0033 Eukaryota
ENOG410XNRX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156481

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108055

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13555

KEGG Orthology (KO)

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KOi
K04515

Identification of Orthologs from Complete Genome Data

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OMAi
AQTTVVH

Database of Orthologous Groups

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OrthoDBi
EOG091G0SCS

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13555

TreeFam database of animal gene trees

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TreeFami
TF315229

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013543 Ca/CaM-dep_prot_kinase-assoc
IPR039071 CAMK2
IPR011009 Kinase-like_dom_sf
IPR032710 NTF2-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

The PANTHER Classification System

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PANTHERi
PTHR43940 PTHR43940, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08332 CaMKII_AD, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54427 SSF54427, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 11 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 11 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13555-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL
60 70 80 90 100
SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE
110 120 130 140 150
DIVAREYYSE ADASHCIHQI LESVNHIHQH DIVHRDLKPE NLLLASKCKG
160 170 180 190 200
AAVKLADFGL AIEVQGEQQA WFGFAGTPGY LSPEVLRKDP YGKPVDIWAC
210 220 230 240 250
GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN
260 270 280 290 300
QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL
310 320 330 340 350
KGAILTTMLV SRNFSAAKSL LNKKSDGGVK KRKSSSSVHL MPQSNNKNSL
360 370 380 390 400
VSPAQEPAPL QTAMEPQTTV VHNATDGIKG STESCNTTTE DEDLKGRVPE
410 420 430 440 450
GRSSRDRTAP SAGMQPQPSL CSSAMRKQEI IKITEQLIEA INNGDFEAYT
460 470 480 490 500
KICDPGLTSF EPEALGNLVE GMDFHKFYFE NLLSKNSKPI HTTILNPHVH
510 520 530 540 550
VIGEDAACIA YIRLTQYIDG QGRPRTSQSE ETRVWHRRDG KWLNVHYHCS

GAPAAPLQ
Length:558
Mass (Da):62,607
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D61AB799B8F8CEB
GO
Isoform 2 (identifier: Q13555-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-341: Missing.

Show »
Length:547
Mass (Da):61,366
Checksum:i5FAED70538A78AB7
GO
Isoform 3 (identifier: Q13555-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-364: Missing.

Show »
Length:524
Mass (Da):58,961
Checksum:i30545DE58E5598C6
GO
Isoform 4 (identifier: Q13555-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     396-425: GRVPEGRSSRDRTAPSAGMQPQPSLCSSAM → V

Show »
Length:529
Mass (Da):59,607
Checksum:iEE1D127BBA178544
GO
Isoform 5 (identifier: Q13555-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-315: S → SVGRQSSAPASPAASAAGLAGQ
     341-363: Missing.
     396-425: GRVPEGRSSRDRTAPSAGMQPQPSLCSSAM → V

Show »
Length:527
Mass (Da):59,038
Checksum:i58DBF1B72F64FA31
GO
Isoform 6 (identifier: Q13555-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-315: S → SVGRQSSAPASPAASAAGLAGQ
     397-398: RV → APLRTGNGSSV

Show »
Length:588
Mass (Da):65,228
Checksum:i6244199DF09FCF38
GO
Isoform 7 (identifier: Q13555-7) [UniParc]FASTAAdd to basket
Also known as: gamma F

The sequence of this isoform differs from the canonical sequence as follows:
     331-364: Missing.
     397-398: RV → APLRTGNGSSV

Show »
Length:533
Mass (Da):59,746
Checksum:iCF6A1A178AE5DF0D
GO
Isoform 8 (identifier: Q13555-8) [UniParc]FASTAAdd to basket
Also known as: gamma E

The sequence of this isoform differs from the canonical sequence as follows:
     331-341: Missing.
     397-398: RV → APLRTGNGSSV

Show »
Length:556
Mass (Da):62,151
Checksum:iF9CC1D21E815E575
GO
Isoform 9 (identifier: Q13555-9) [UniParc]FASTAAdd to basket
Also known as: gamma D

The sequence of this isoform differs from the canonical sequence as follows:
     331-341: Missing.
     351-364: Missing.
     397-398: RV → APLRTGNGSSV

Show »
Length:542
Mass (Da):60,729
Checksum:iD0DD900AB8D93A88
GO
Isoform 10 (identifier: Q13555-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-364: Missing.
     396-425: GRVPEGRSSRDRTAPSAGMQPQPSLCSSAM → V

Show »
Length:495
Mass (Da):55,961
Checksum:i168EA409723DF4C4
GO
Isoform 11 (identifier: Q13555-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: A → VGRQSSAPASPAASAAGLAGQA
     331-341: Missing.
     396-426: GRVPEGRSSRDRTAPSAGMQPQPSLCSSAMR → VR

Show »
Length:539
Mass (Da):60,201
Checksum:i24989285F7564529
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Q3DQE3A0A2Q3DQE3_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2G hCG_20541
556Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SWX3Q5SWX3_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2G hCG_20541
516Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6G2H0Y6G2_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2G
335Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8WU40Q8WU40_HUMAN
CAMK2G protein
CAMK2G
453Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB61379 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230A → T in AAB61379 (PubMed:8449910).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04243036S → P2 PublicationsCorresponds to variant dbSNP:rs17853266Ensembl.1
Natural variantiVAR_069390292R → P Found in a patient with severe mental retardation, myopia, strabismus; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs397514627EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032699315S → SVGRQSSAPASPAASAAGLA GQ in isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_059393316A → VGRQSSAPASPAASAAGLAG QA in isoform 11. 1
Alternative sequenceiVSP_013350331 – 364Missing in isoform 3, isoform 7 and isoform 10. 2 PublicationsAdd BLAST34
Alternative sequenceiVSP_013349331 – 341Missing in isoform 2, isoform 8, isoform 9 and isoform 11. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_032700341 – 363Missing in isoform 5. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_036027351 – 364Missing in isoform 9. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_059394396 – 426GRVPE…SSAMR → VR in isoform 11. Add BLAST31
Alternative sequenceiVSP_004778396 – 425GRVPE…CSSAM → V in isoform 4, isoform 5 and isoform 10. 3 PublicationsAdd BLAST30
Alternative sequenceiVSP_035456397 – 398RV → APLRTGNGSSV in isoform 6, isoform 7, isoform 8 and isoform 9. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC022400 Genomic DNA No translation available.
AL596247 Genomic DNA No translation available.
AL713896 Genomic DNA No translation available.
KF455257 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54527.1
CH471083 Genomic DNA Translation: EAW54532.1
CH471083 Genomic DNA Translation: EAW54536.1
BC034044 mRNA Translation: AAH34044.1
U66064 mRNA Translation: AAB80848.1
AH011636 Genomic DNA Translation: AAM33514.1
L07043 mRNA Translation: AAB61379.1 Different initiation.
U50359 mRNA Translation: AAB16864.1
U50360 mRNA Translation: AAB16865.1
U32472 mRNA Translation: AAA75201.1
U32473 mRNA Translation: AAA75202.1
U32509 mRNA Translation: AAA75203.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73153.1 [Q13555-11]
CCDS7336.1 [Q13555-10]
CCDS7337.1 [Q13555-5]
CCDS7338.1 [Q13555-8]

Protein sequence database of the Protein Information Resource

More...
PIRi
G01975
G01978

NCBI Reference Sequences

More...
RefSeqi
NP_001191421.1, NM_001204492.1 [Q13555-11]
NP_001213.2, NM_001222.3 [Q13555-10]
NP_001307827.1, NM_001320898.1
NP_751909.1, NM_172169.2 [Q13555-5]
NP_751913.1, NM_172173.2
XP_005270260.1, XM_005270203.1 [Q13555-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.523045
Hs.654811

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305762; ENSP00000307082; ENSG00000148660 [Q13555-4]
ENST00000322635; ENSP00000315599; ENSG00000148660 [Q13555-5]
ENST00000351293; ENSP00000277853; ENSG00000148660 [Q13555-10]
ENST00000394762; ENSP00000378243; ENSG00000148660 [Q13555-11]
ENST00000423381; ENSP00000410298; ENSG00000148660 [Q13555-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
818

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:818

UCSC genome browser

More...
UCSCi
uc001jvm.2 human [Q13555-1]
uc001jvs.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022400 Genomic DNA No translation available.
AL596247 Genomic DNA No translation available.
AL713896 Genomic DNA No translation available.
KF455257 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54527.1
CH471083 Genomic DNA Translation: EAW54532.1
CH471083 Genomic DNA Translation: EAW54536.1
BC034044 mRNA Translation: AAH34044.1
U66064 mRNA Translation: AAB80848.1
AH011636 Genomic DNA Translation: AAM33514.1
L07043 mRNA Translation: AAB61379.1 Different initiation.
U50359 mRNA Translation: AAB16864.1
U50360 mRNA Translation: AAB16865.1
U32472 mRNA Translation: AAA75201.1
U32473 mRNA Translation: AAA75202.1
U32509 mRNA Translation: AAA75203.1
CCDSiCCDS73153.1 [Q13555-11]
CCDS7336.1 [Q13555-10]
CCDS7337.1 [Q13555-5]
CCDS7338.1 [Q13555-8]
PIRiG01975
G01978
RefSeqiNP_001191421.1, NM_001204492.1 [Q13555-11]
NP_001213.2, NM_001222.3 [Q13555-10]
NP_001307827.1, NM_001320898.1
NP_751909.1, NM_172169.2 [Q13555-5]
NP_751913.1, NM_172173.2
XP_005270260.1, XM_005270203.1 [Q13555-4]
UniGeneiHs.523045
Hs.654811

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2UX0X-ray2.46A/B/C/D/E/F426-558[»]
2V7OX-ray2.25A5-315[»]
ProteinModelPortaliQ13555
SMRiQ13555
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107268, 51 interactors
DIPiDIP-51315N
IntActiQ13555, 43 interactors
MINTiQ13555
STRINGi9606.ENSP00000319060

Chemistry databases

BindingDBiQ13555
ChEMBLiCHEMBL3829
DrugBankiDB06616 Bosutinib
GuidetoPHARMACOLOGYi1557

PTM databases

iPTMnetiQ13555
PhosphoSitePlusiQ13555

Polymorphism and mutation databases

BioMutaiCAMK2G
DMDMi62512173

Proteomic databases

EPDiQ13555
PaxDbiQ13555
PeptideAtlasiQ13555
PRIDEiQ13555
ProteomicsDBi59538
59539 [Q13555-10]
59540 [Q13555-2]
59541 [Q13555-3]
59542 [Q13555-4]
59543 [Q13555-5]
59544 [Q13555-6]
59545 [Q13555-7]
59546 [Q13555-8]
59547 [Q13555-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
818
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305762; ENSP00000307082; ENSG00000148660 [Q13555-4]
ENST00000322635; ENSP00000315599; ENSG00000148660 [Q13555-5]
ENST00000351293; ENSP00000277853; ENSG00000148660 [Q13555-10]
ENST00000394762; ENSP00000378243; ENSG00000148660 [Q13555-11]
ENST00000423381; ENSP00000410298; ENSG00000148660 [Q13555-1]
GeneIDi818
KEGGihsa:818
UCSCiuc001jvm.2 human [Q13555-1]
uc001jvs.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
818
DisGeNETi818
EuPathDBiHostDB:ENSG00000148660.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CAMK2G
HGNCiHGNC:1463 CAMK2G
HPAiHPA040656
HPA051783
HPA051785
HPA053973
MIMi602123 gene
neXtProtiNX_Q13555
OpenTargetsiENSG00000148660
PharmGKBiPA93

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0033 Eukaryota
ENOG410XNRX LUCA
GeneTreeiENSGT00940000156481
HOVERGENiHBG108055
InParanoidiQ13555
KOiK04515
OMAiAQTTVVH
OrthoDBiEOG091G0SCS
PhylomeDBiQ13555
TreeFamiTF315229

Enzyme and pathway databases

BRENDAi2.7.11.17 2681
ReactomeiR-HSA-3371571 HSF1-dependent transactivation
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5578775 Ion homeostasis
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-877300 Interferon gamma signaling
R-HSA-9022692 Regulation of MECP2 expression and activity
R-HSA-936837 Ion transport by P-type ATPases
SignaLinkiQ13555
SIGNORiQ13555

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CAMK2G human
EvolutionaryTraceiQ13555

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CAMK2G

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
818

Protein Ontology

More...
PROi
PR:Q13555

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148660 Expressed in 223 organ(s), highest expression level in lower esophagus
ExpressionAtlasiQ13555 baseline and differential
GenevisibleiQ13555 HS

Family and domain databases

InterProiView protein in InterPro
IPR013543 Ca/CaM-dep_prot_kinase-assoc
IPR039071 CAMK2
IPR011009 Kinase-like_dom_sf
IPR032710 NTF2-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR43940 PTHR43940, 1 hit
PfamiView protein in Pfam
PF08332 CaMKII_AD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCC2G_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13555
Secondary accession number(s): A0A0A0MS52
, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 28, 2018
Last modified: December 5, 2018
This is version 191 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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