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Protein

Calcium/calmodulin-dependent protein kinase type II subunit beta

Gene

CAMK2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by Ca2+/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca2+-independent activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei43ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi20 – 28ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.17 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5578775 Ion homeostasis
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-877300 Interferon gamma signaling
R-HSA-9022692 Regulation of MECP2 expression and activity
R-HSA-936837 Ion transport by P-type ATPases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q13554

SIGNOR Signaling Network Open Resource

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SIGNORi
Q13554

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type II subunit beta (EC:2.7.11.17)
Short name:
CaM kinase II subunit beta
Short name:
CaMK-II subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAMK2B
Synonyms:CAM2, CAMK2, CAMKB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000058404.19

Human Gene Nomenclature Database

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HGNCi
HGNC:1461 CAMK2B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607707 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13554

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane, Sarcoplasmic reticulum, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal dominant 54 (MRD54)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
See also OMIM:617799
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08058829 – 666Missing in MRD54. 1 PublicationAdd BLAST638
Natural variantiVAR_080589110E → K in MRD54; decreased protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080590139P → L in MRD54; decreased protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080591237E → K in MRD54; no effect on protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080592301K → E in MRD54; no effect on protein abundance; loss of autophosphorylation; changed function in neuronal migration. 1 Publication1

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
816

MalaCards human disease database

More...
MalaCardsi
CAMK2B
MIMi617799 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000058404

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
178469 Autosomal dominant non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA91

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4121

Drug and drug target database

More...
DrugBanki
DB07168 [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1556

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CAMK2B

Domain mapping of disease mutations (DMDM)

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DMDMi
334302890

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000860961 – 666Calcium/calmodulin-dependent protein kinase type II subunit betaAdd BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphotyrosineBy similarity1
Modified residuei287Phosphothreonine; by autocatalysis1 Publication1
Modified residuei306Phosphothreonine; by autocatalysisBy similarity1
Modified residuei307Phosphothreonine; by autocatalysisBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei394PhosphoserineBy similarity1
Modified residuei397PhosphoserineBy similarity1
Modified residuei400PhosphothreonineBy similarity1
Modified residuei401PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylation of Thr-287 following activation by Ca2+/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13554

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13554

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13554

PeptideAtlas

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PeptideAtlasi
Q13554

PRoteomics IDEntifications database

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PRIDEi
Q13554

ProteomicsDB human proteome resource

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ProteomicsDBi
59530
59531 [Q13554-2]
59532 [Q13554-3]
59533 [Q13554-4]
59534 [Q13554-5]
59535 [Q13554-6]
59536 [Q13554-7]
59537 [Q13554-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13554

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13554

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Activity is induced in skeletal muscle during exercise.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000058404 Expressed in 167 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13554 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13554 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB006849
HPA026307
HPA051783
HPA051785
HPA053973

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (PubMed:14722083, Ref. 19). Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ (PubMed:15312654). Interacts with FOXO3 (By similarity). Interacts (when in a kinase inactive state not associated with calmodulin) with ARC; leading to target ARC to inactive synapses (By similarity).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107266, 52 interactors

Database of interacting proteins

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DIPi
DIP-39770N

Protein interaction database and analysis system

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IntActi
Q13554, 49 interactors

Molecular INTeraction database

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MINTi
Q13554

STRING: functional protein association networks

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STRINGi
9606.ENSP00000379098

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q13554

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1666
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13554

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13554

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q13554

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 272Protein kinasePROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni283 – 292Autoinhibitory domainBy similarity10
Regioni291 – 301Calmodulin-bindingAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0033 Eukaryota
ENOG410XNRX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158973

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108055

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13554

KEGG Orthology (KO)

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KOi
K04515

Identification of Orthologs from Complete Genome Data

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OMAi
NVHFHGS

Database of Orthologous Groups

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OrthoDBi
EOG091G0SCS

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13554

TreeFam database of animal gene trees

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TreeFami
TF315229

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013543 Ca/CaM-dep_prot_kinase-assoc
IPR039071 CAMK2
IPR011009 Kinase-like_dom_sf
IPR032710 NTF2-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

The PANTHER Classification System

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PANTHERi
PTHR43940 PTHR43940, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08332 CaMKII_AD, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54427 SSF54427, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms.

This entry has 8 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q13554-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL
60 70 80 90 100
SARDHQKLER EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE
110 120 130 140 150
DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKCKG
160 170 180 190 200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKEA YGKPVDIWAC
210 220 230 240 250
GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN
260 270 280 290 300
QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL
310 320 330 340 350
KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD
360 370 380 390 400
GVKPQTNSTK NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT
410 420 430 440 450
TIEDEDAKAP RVPDILSSVR RGSGAPEAEG PLPCPSPAPF SPLPAPSPRI
460 470 480 490 500
SDILNSVRRG SGTPEAEGPL SAGPPPCLSP ALLGPLSSPS PRISDILNSV
510 520 530 540 550
RRGSGTPEAE GPSPVGPPPC PSPTIPGPLP TPSRKQEIIK TTEQLIEAVN
560 570 580 590 600
NGDFEAYAKI CDPGLTSFEP EALGNLVEGM DFHRFYFENL LAKNSKPIHT
610 620 630 640 650
TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW
660
QNVHFHCSGA PVAPLQ
Length:666
Mass (Da):72,678
Last modified:May 31, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CACFC3E392C3857
GO
Isoform 1 (identifier: Q13554-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     410-533: Missing.

Show »
Length:542
Mass (Da):60,387
Checksum:i1F7AF874A78C9D26
GO
Isoform 2 (identifier: Q13554-3) [UniParc]FASTAAdd to basket
Also known as: Beta1, Beta'E

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     379-393: Missing.
     410-533: Missing.

Show »
Length:503
Mass (Da):56,379
Checksum:i4389A566D66A9FE1
GO
Isoform 3 (identifier: Q13554-4) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     354-392: Missing.
     410-533: Missing.

Show »
Length:479
Mass (Da):54,074
Checksum:iE8A4B57BD6AA98AC
GO
Isoform 5 (identifier: Q13554-5) [UniParc]FASTAAdd to basket
Also known as: Beta4, BetaE

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     410-533: Missing.

Show »
Length:518
Mass (Da):58,009
Checksum:i5853A731579E86D8
GO
Isoform 6 (identifier: Q13554-6) [UniParc]FASTAAdd to basket
Also known as: Beta6

The sequence of this isoform differs from the canonical sequence as follows:
     354-377: Missing.
     410-533: Missing.
     559-584: Missing.

Show »
Length:492
Mass (Da):55,223
Checksum:i1102B7F9B979E307
GO
Isoform 7 (identifier: Q13554-7) [UniParc]FASTAAdd to basket
Also known as: Beta7

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-533: Missing.

Show »
Length:449
Mass (Da):50,955
Checksum:i6EB6617646B54829
GO
Isoform 8 (identifier: Q13554-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-340: Missing.
     410-533: Missing.

Show »
Length:517
Mass (Da):57,938
Checksum:i1F4A8797FB7458A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXS4H7BXS4_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
362Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBE8E9PBE8_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETC9E7ETC9_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQE4E7EQE4_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERS6E7ERS6_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C394H7C394_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZC6H7BZC6_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC99802 differs from that shown. Reason: Frameshift at positions 426, 433, 511 and 516.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68L → V in AAD03744 (Ref. 3) Curated1
Sequence conflicti68L → V in AAD03743 (Ref. 3) Curated1
Sequence conflicti535K → N in AAB16863 (PubMed:9060999).Curated1
Isoform 2 (identifier: Q13554-3)
Sequence conflicti316A → V in AAD42036 (PubMed:10858498).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08058829 – 666Missing in MRD54. 1 PublicationAdd BLAST638
Natural variantiVAR_080589110E → K in MRD54; decreased protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080590139P → L in MRD54; decreased protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080591237E → K in MRD54; no effect on protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080592301K → E in MRD54; no effect on protein abundance; loss of autophosphorylation; changed function in neuronal migration. 1 Publication1
Natural variantiVAR_045581489P → L in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs555460132Ensembl.1
Natural variantiVAR_045582510E → K1 PublicationCorresponds to variant dbSNP:rs35452727Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041219316 – 340Missing in isoform 8. CuratedAdd BLAST25
Alternative sequenceiVSP_004770316V → A in isoform 2, isoform 3, isoform 5 and isoform 7. 6 Publications1
Alternative sequenceiVSP_004772317 – 533Missing in isoform 7. 1 PublicationAdd BLAST217
Alternative sequenceiVSP_004771317 – 340Missing in isoform 2, isoform 3 and isoform 5. 6 PublicationsAdd BLAST24
Alternative sequenceiVSP_004774354 – 392Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_004773354 – 377Missing in isoform 6. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_004775379 – 393Missing in isoform 2. 5 PublicationsAdd BLAST15
Alternative sequenceiVSP_004776410 – 533Missing in isoform 1, isoform 2, isoform 3, isoform 5, isoform 6 and isoform 8. 6 PublicationsAdd BLAST124
Alternative sequenceiVSP_004777559 – 584Missing in isoform 6. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF078803 mRNA Translation: AAD42035.1
AF081572 mRNA Translation: AAD42036.1
AF081924 mRNA Translation: AAD42037.1
AF083419 mRNA Translation: AAD42038.1
AF140350 mRNA Translation: AAD42070.1
U23460 mRNA Translation: AAC99802.1 Frameshift.
AF112472 mRNA Translation: AAD03744.1
AF112471 mRNA Translation: AAD03743.1
AJ252236 mRNA Translation: CAB65120.1
AJ252237 mRNA Translation: CAB65121.1
AJ252238 mRNA Translation: CAB65122.1
AK290148 mRNA Translation: BAF82837.1
AK315663 mRNA Translation: BAG38029.1
CH236960 Genomic DNA Translation: EAL23756.1
CH236960 Genomic DNA Translation: EAL23757.1
CH236960 Genomic DNA Translation: EAL23758.1
CH236960 Genomic DNA Translation: EAL23759.1
CH236960 Genomic DNA Translation: EAL23760.1
CH236960 Genomic DNA Translation: EAL23761.1
CH236960 Genomic DNA Translation: EAL23762.1
BC019070 mRNA Translation: AAH19070.1
U50358 mRNA Translation: AAB16863.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43573.1 [Q13554-8]
CCDS5483.1 [Q13554-1]
CCDS5484.1 [Q13554-2]
CCDS5485.1 [Q13554-5]
CCDS5486.1 [Q13554-3]
CCDS5487.1 [Q13554-6]
CCDS5488.1 [Q13554-4]
CCDS5489.1 [Q13554-7]

NCBI Reference Sequences

More...
RefSeqi
NP_001211.3, NM_001220.4 [Q13554-1]
NP_001280099.1, NM_001293170.1 [Q13554-2]
NP_742075.1, NM_172078.2 [Q13554-2]
NP_742076.1, NM_172079.2 [Q13554-5]
NP_742077.1, NM_172080.2 [Q13554-8]
NP_742078.1, NM_172081.2 [Q13554-3]
NP_742079.1, NM_172082.2 [Q13554-6]
NP_742080.1, NM_172083.2 [Q13554-4]
NP_742081.1, NM_172084.2 [Q13554-7]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.351887

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258682; ENSP00000258682; ENSG00000058404 [Q13554-8]
ENST00000346990; ENSP00000326518; ENSG00000058404 [Q13554-7]
ENST00000347193; ENSP00000326544; ENSG00000058404 [Q13554-6]
ENST00000350811; ENSP00000326375; ENSG00000058404 [Q13554-2]
ENST00000353625; ENSP00000326427; ENSG00000058404 [Q13554-4]
ENST00000358707; ENSP00000351542; ENSG00000058404 [Q13554-3]
ENST00000395747; ENSP00000379096; ENSG00000058404 [Q13554-5]
ENST00000395749; ENSP00000379098; ENSG00000058404 [Q13554-1]
ENST00000440254; ENSP00000397937; ENSG00000058404 [Q13554-2]
ENST00000457475; ENSP00000390292; ENSG00000058404 [Q13554-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
816

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:816

UCSC genome browser

More...
UCSCi
uc003tkp.3 human [Q13554-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078803 mRNA Translation: AAD42035.1
AF081572 mRNA Translation: AAD42036.1
AF081924 mRNA Translation: AAD42037.1
AF083419 mRNA Translation: AAD42038.1
AF140350 mRNA Translation: AAD42070.1
U23460 mRNA Translation: AAC99802.1 Frameshift.
AF112472 mRNA Translation: AAD03744.1
AF112471 mRNA Translation: AAD03743.1
AJ252236 mRNA Translation: CAB65120.1
AJ252237 mRNA Translation: CAB65121.1
AJ252238 mRNA Translation: CAB65122.1
AK290148 mRNA Translation: BAF82837.1
AK315663 mRNA Translation: BAG38029.1
CH236960 Genomic DNA Translation: EAL23756.1
CH236960 Genomic DNA Translation: EAL23757.1
CH236960 Genomic DNA Translation: EAL23758.1
CH236960 Genomic DNA Translation: EAL23759.1
CH236960 Genomic DNA Translation: EAL23760.1
CH236960 Genomic DNA Translation: EAL23761.1
CH236960 Genomic DNA Translation: EAL23762.1
BC019070 mRNA Translation: AAH19070.1
U50358 mRNA Translation: AAB16863.1
CCDSiCCDS43573.1 [Q13554-8]
CCDS5483.1 [Q13554-1]
CCDS5484.1 [Q13554-2]
CCDS5485.1 [Q13554-5]
CCDS5486.1 [Q13554-3]
CCDS5487.1 [Q13554-6]
CCDS5488.1 [Q13554-4]
CCDS5489.1 [Q13554-7]
RefSeqiNP_001211.3, NM_001220.4 [Q13554-1]
NP_001280099.1, NM_001293170.1 [Q13554-2]
NP_742075.1, NM_172078.2 [Q13554-2]
NP_742076.1, NM_172079.2 [Q13554-5]
NP_742077.1, NM_172080.2 [Q13554-8]
NP_742078.1, NM_172081.2 [Q13554-3]
NP_742079.1, NM_172082.2 [Q13554-6]
NP_742080.1, NM_172083.2 [Q13554-4]
NP_742081.1, NM_172084.2 [Q13554-7]
UniGeneiHs.351887

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BHHX-ray2.40A/B/C/D11-303[»]
ProteinModelPortaliQ13554
SMRiQ13554
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107266, 52 interactors
DIPiDIP-39770N
IntActiQ13554, 49 interactors
MINTiQ13554
STRINGi9606.ENSP00000379098

Chemistry databases

BindingDBiQ13554
ChEMBLiCHEMBL4121
DrugBankiDB07168 [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
GuidetoPHARMACOLOGYi1556

PTM databases

iPTMnetiQ13554
PhosphoSitePlusiQ13554

Polymorphism and mutation databases

BioMutaiCAMK2B
DMDMi334302890

Proteomic databases

EPDiQ13554
MaxQBiQ13554
PaxDbiQ13554
PeptideAtlasiQ13554
PRIDEiQ13554
ProteomicsDBi59530
59531 [Q13554-2]
59532 [Q13554-3]
59533 [Q13554-4]
59534 [Q13554-5]
59535 [Q13554-6]
59536 [Q13554-7]
59537 [Q13554-8]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
816
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258682; ENSP00000258682; ENSG00000058404 [Q13554-8]
ENST00000346990; ENSP00000326518; ENSG00000058404 [Q13554-7]
ENST00000347193; ENSP00000326544; ENSG00000058404 [Q13554-6]
ENST00000350811; ENSP00000326375; ENSG00000058404 [Q13554-2]
ENST00000353625; ENSP00000326427; ENSG00000058404 [Q13554-4]
ENST00000358707; ENSP00000351542; ENSG00000058404 [Q13554-3]
ENST00000395747; ENSP00000379096; ENSG00000058404 [Q13554-5]
ENST00000395749; ENSP00000379098; ENSG00000058404 [Q13554-1]
ENST00000440254; ENSP00000397937; ENSG00000058404 [Q13554-2]
ENST00000457475; ENSP00000390292; ENSG00000058404 [Q13554-5]
GeneIDi816
KEGGihsa:816
UCSCiuc003tkp.3 human [Q13554-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
816
DisGeNETi816
EuPathDBiHostDB:ENSG00000058404.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CAMK2B
HGNCiHGNC:1461 CAMK2B
HPAiCAB006849
HPA026307
HPA051783
HPA051785
HPA053973
MalaCardsiCAMK2B
MIMi607707 gene
617799 phenotype
neXtProtiNX_Q13554
OpenTargetsiENSG00000058404
Orphaneti178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBiPA91

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0033 Eukaryota
ENOG410XNRX LUCA
GeneTreeiENSGT00940000158973
HOVERGENiHBG108055
InParanoidiQ13554
KOiK04515
OMAiNVHFHGS
OrthoDBiEOG091G0SCS
PhylomeDBiQ13554
TreeFamiTF315229

Enzyme and pathway databases

BRENDAi2.7.11.17 2681
ReactomeiR-HSA-3371571 HSF1-dependent transactivation
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5578775 Ion homeostasis
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-877300 Interferon gamma signaling
R-HSA-9022692 Regulation of MECP2 expression and activity
R-HSA-936837 Ion transport by P-type ATPases
SignaLinkiQ13554
SIGNORiQ13554

Miscellaneous databases

EvolutionaryTraceiQ13554

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CAMK2B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
816

Protein Ontology

More...
PROi
PR:Q13554

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000058404 Expressed in 167 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ13554 baseline and differential
GenevisibleiQ13554 HS

Family and domain databases

InterProiView protein in InterPro
IPR013543 Ca/CaM-dep_prot_kinase-assoc
IPR039071 CAMK2
IPR011009 Kinase-like_dom_sf
IPR032710 NTF2-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR43940 PTHR43940, 1 hit
PfamiView protein in Pfam
PF08332 CaMKII_AD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCC2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13554
Secondary accession number(s): A4D2K0
, A4D2K1, A4D2K2, A4D2K3, A4D2K4, A4D2K5, A4D2K6, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 31, 2011
Last modified: December 5, 2018
This is version 195 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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