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Protein

Calcium/calmodulin-dependent protein kinase type II subunit beta

Gene

CAMK2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Activated by Ca2+/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca2+-independent activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43ATPPROSITE-ProRule annotation1
Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 28ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.17 2681
ReactomeiR-HSA-3371571 HSF1-dependent transactivation
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5578775 Ion homeostasis
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-877300 Interferon gamma signaling
R-HSA-936837 Ion transport by P-type ATPases
SignaLinkiQ13554
SIGNORiQ13554

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type II subunit beta (EC:2.7.11.17)
Short name:
CaM kinase II subunit beta
Short name:
CaMK-II subunit beta
Gene namesi
Name:CAMK2B
Synonyms:CAM2, CAMK2, CAMKB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000058404.19
HGNCiHGNC:1461 CAMK2B
MIMi607707 gene
neXtProtiNX_Q13554

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane, Sarcoplasmic reticulum, Synapse

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal dominant 54 (MRD54)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
See also OMIM:617799
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08058829 – 666Missing in MRD54. 1 PublicationAdd BLAST638
Natural variantiVAR_080589110E → K in MRD54; decreased protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080590139P → L in MRD54; decreased protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080591237E → K in MRD54; no effect on protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080592301K → E in MRD54; no effect on protein abundance; loss of autophosphorylation; changed function in neuronal migration. 1 Publication1

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNETi816
MalaCardsiCAMK2B
MIMi617799 phenotype
OpenTargetsiENSG00000058404
PharmGKBiPA91

Chemistry databases

ChEMBLiCHEMBL4121
DrugBankiDB07168 [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
GuidetoPHARMACOLOGYi1556

Polymorphism and mutation databases

BioMutaiCAMK2B
DMDMi334302890

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000860961 – 666Calcium/calmodulin-dependent protein kinase type II subunit betaAdd BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphotyrosineBy similarity1
Modified residuei287Phosphothreonine; by autocatalysis1 Publication1
Modified residuei306Phosphothreonine; by autocatalysisBy similarity1
Modified residuei307Phosphothreonine; by autocatalysisBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei394PhosphoserineBy similarity1
Modified residuei397PhosphoserineBy similarity1
Modified residuei400PhosphothreonineBy similarity1
Modified residuei401PhosphothreonineCombined sources1

Post-translational modificationi

Autophosphorylation of Thr-287 following activation by Ca2+/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13554
MaxQBiQ13554
PaxDbiQ13554
PeptideAtlasiQ13554
PRIDEiQ13554
ProteomicsDBi59530
59531 [Q13554-2]
59532 [Q13554-3]
59533 [Q13554-4]
59534 [Q13554-5]
59535 [Q13554-6]
59536 [Q13554-7]
59537 [Q13554-8]

PTM databases

iPTMnetiQ13554
PhosphoSitePlusiQ13554

Expressioni

Tissue specificityi

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.1 Publication

Inductioni

Activity is induced in skeletal muscle during exercise.1 Publication

Gene expression databases

BgeeiENSG00000058404 Expressed in 167 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ13554 baseline and differential
GenevisibleiQ13554 HS

Organism-specific databases

HPAiCAB006849
HPA026307
HPA051783
HPA051785
HPA053973

Interactioni

Subunit structurei

CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (PubMed:14722083, Ref. 19). Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ (PubMed:15312654). Interacts with FOXO3 (By similarity). Interacts (when in a kinase inactive state not associated with calmodulin) with ARC; leading to target ARC to inactive synapses (By similarity).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107266, 52 interactors
DIPiDIP-39770N
IntActiQ13554, 48 interactors
MINTiQ13554
STRINGi9606.ENSP00000379098

Chemistry databases

BindingDBiQ13554

Structurei

Secondary structure

1666
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13554
SMRiQ13554
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13554

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 272Protein kinasePROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni283 – 292Autoinhibitory domainBy similarity10
Regioni291 – 301Calmodulin-bindingAdd BLAST11

Domaini

The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0033 Eukaryota
ENOG410XNRX LUCA
GeneTreeiENSGT00760000118944
HOVERGENiHBG108055
InParanoidiQ13554
KOiK04515
OMAiNVHFHGS
OrthoDBiEOG091G0SCS
PhylomeDBiQ13554
TreeFamiTF315229

Family and domain databases

InterProiView protein in InterPro
IPR013543 Ca/CaM-dep_prot_kinase-assoc
IPR039071 CAMK2
IPR011009 Kinase-like_dom_sf
IPR032710 NTF2-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR43940 PTHR43940, 1 hit
PfamiView protein in Pfam
PF08332 CaMKII_AD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket
Note: The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms.

This entry has 8 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q13554-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL
60 70 80 90 100
SARDHQKLER EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE
110 120 130 140 150
DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKCKG
160 170 180 190 200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKEA YGKPVDIWAC
210 220 230 240 250
GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN
260 270 280 290 300
QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL
310 320 330 340 350
KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD
360 370 380 390 400
GVKPQTNSTK NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT
410 420 430 440 450
TIEDEDAKAP RVPDILSSVR RGSGAPEAEG PLPCPSPAPF SPLPAPSPRI
460 470 480 490 500
SDILNSVRRG SGTPEAEGPL SAGPPPCLSP ALLGPLSSPS PRISDILNSV
510 520 530 540 550
RRGSGTPEAE GPSPVGPPPC PSPTIPGPLP TPSRKQEIIK TTEQLIEAVN
560 570 580 590 600
NGDFEAYAKI CDPGLTSFEP EALGNLVEGM DFHRFYFENL LAKNSKPIHT
610 620 630 640 650
TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW
660
QNVHFHCSGA PVAPLQ
Length:666
Mass (Da):72,678
Last modified:May 31, 2011 - v3
Checksum:i8CACFC3E392C3857
GO
Isoform 1 (identifier: Q13554-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     410-533: Missing.

Show »
Length:542
Mass (Da):60,387
Checksum:i1F7AF874A78C9D26
GO
Isoform 2 (identifier: Q13554-3) [UniParc]FASTAAdd to basket
Also known as: Beta1, Beta'E

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     379-393: Missing.
     410-533: Missing.

Show »
Length:503
Mass (Da):56,379
Checksum:i4389A566D66A9FE1
GO
Isoform 3 (identifier: Q13554-4) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     354-392: Missing.
     410-533: Missing.

Show »
Length:479
Mass (Da):54,074
Checksum:iE8A4B57BD6AA98AC
GO
Isoform 5 (identifier: Q13554-5) [UniParc]FASTAAdd to basket
Also known as: Beta4, BetaE

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     410-533: Missing.

Show »
Length:518
Mass (Da):58,009
Checksum:i5853A731579E86D8
GO
Isoform 6 (identifier: Q13554-6) [UniParc]FASTAAdd to basket
Also known as: Beta6

The sequence of this isoform differs from the canonical sequence as follows:
     354-377: Missing.
     410-533: Missing.
     559-584: Missing.

Show »
Length:492
Mass (Da):55,223
Checksum:i1102B7F9B979E307
GO
Isoform 7 (identifier: Q13554-7) [UniParc]FASTAAdd to basket
Also known as: Beta7

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-533: Missing.

Show »
Length:449
Mass (Da):50,955
Checksum:i6EB6617646B54829
GO
Isoform 8 (identifier: Q13554-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-340: Missing.
     410-533: Missing.

Show »
Length:517
Mass (Da):57,938
Checksum:i1F4A8797FB7458A4
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXS4H7BXS4_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
362Annotation score:
E9PBE8E9PBE8_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
168Annotation score:
E7EQE4E7EQE4_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
173Annotation score:
E7ETC9E7ETC9_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
180Annotation score:
E7ERS6E7ERS6_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
112Annotation score:
H7C394H7C394_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
184Annotation score:
H7BZC6H7BZC6_HUMAN
Calcium/calmodulin-dependent protei...
CAMK2B
184Annotation score:

Sequence cautioni

The sequence AAC99802 differs from that shown. Reason: Frameshift at positions 426, 433, 511 and 516.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68L → V in AAD03744 (Ref. 3) Curated1
Sequence conflicti68L → V in AAD03743 (Ref. 3) Curated1
Sequence conflicti535K → N in AAB16863 (PubMed:9060999).Curated1
Isoform 2 (identifier: Q13554-3)
Sequence conflicti316A → V in AAD42036 (PubMed:10858498).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08058829 – 666Missing in MRD54. 1 PublicationAdd BLAST638
Natural variantiVAR_080589110E → K in MRD54; decreased protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080590139P → L in MRD54; decreased protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080591237E → K in MRD54; no effect on protein abundance; increased autophosphorylation; decreased neuronal migration. 1 Publication1
Natural variantiVAR_080592301K → E in MRD54; no effect on protein abundance; loss of autophosphorylation; changed function in neuronal migration. 1 Publication1
Natural variantiVAR_045581489P → L in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs555460132Ensembl.1
Natural variantiVAR_045582510E → K1 PublicationCorresponds to variant dbSNP:rs35452727Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041219316 – 340Missing in isoform 8. CuratedAdd BLAST25
Alternative sequenceiVSP_004770316V → A in isoform 2, isoform 3, isoform 5 and isoform 7. 6 Publications1
Alternative sequenceiVSP_004772317 – 533Missing in isoform 7. 1 PublicationAdd BLAST217
Alternative sequenceiVSP_004771317 – 340Missing in isoform 2, isoform 3 and isoform 5. 6 PublicationsAdd BLAST24
Alternative sequenceiVSP_004774354 – 392Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_004773354 – 377Missing in isoform 6. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_004775379 – 393Missing in isoform 2. 5 PublicationsAdd BLAST15
Alternative sequenceiVSP_004776410 – 533Missing in isoform 1, isoform 2, isoform 3, isoform 5, isoform 6 and isoform 8. 6 PublicationsAdd BLAST124
Alternative sequenceiVSP_004777559 – 584Missing in isoform 6. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078803 mRNA Translation: AAD42035.1
AF081572 mRNA Translation: AAD42036.1
AF081924 mRNA Translation: AAD42037.1
AF083419 mRNA Translation: AAD42038.1
AF140350 mRNA Translation: AAD42070.1
U23460 mRNA Translation: AAC99802.1 Frameshift.
AF112472 mRNA Translation: AAD03744.1
AF112471 mRNA Translation: AAD03743.1
AJ252236 mRNA Translation: CAB65120.1
AJ252237 mRNA Translation: CAB65121.1
AJ252238 mRNA Translation: CAB65122.1
AK290148 mRNA Translation: BAF82837.1
AK315663 mRNA Translation: BAG38029.1
CH236960 Genomic DNA Translation: EAL23756.1
CH236960 Genomic DNA Translation: EAL23757.1
CH236960 Genomic DNA Translation: EAL23758.1
CH236960 Genomic DNA Translation: EAL23759.1
CH236960 Genomic DNA Translation: EAL23760.1
CH236960 Genomic DNA Translation: EAL23761.1
CH236960 Genomic DNA Translation: EAL23762.1
BC019070 mRNA Translation: AAH19070.1
U50358 mRNA Translation: AAB16863.1
CCDSiCCDS43573.1 [Q13554-8]
CCDS5483.1 [Q13554-1]
CCDS5484.1 [Q13554-2]
CCDS5485.1 [Q13554-5]
CCDS5486.1 [Q13554-3]
CCDS5487.1 [Q13554-6]
CCDS5488.1 [Q13554-4]
CCDS5489.1 [Q13554-7]
RefSeqiNP_001211.3, NM_001220.4 [Q13554-1]
NP_001280099.1, NM_001293170.1 [Q13554-2]
NP_742075.1, NM_172078.2 [Q13554-2]
NP_742076.1, NM_172079.2 [Q13554-5]
NP_742077.1, NM_172080.2 [Q13554-8]
NP_742078.1, NM_172081.2 [Q13554-3]
NP_742079.1, NM_172082.2 [Q13554-6]
NP_742080.1, NM_172083.2 [Q13554-4]
NP_742081.1, NM_172084.2 [Q13554-7]
UniGeneiHs.351887

Genome annotation databases

EnsembliENST00000258682; ENSP00000258682; ENSG00000058404 [Q13554-8]
ENST00000346990; ENSP00000326518; ENSG00000058404 [Q13554-7]
ENST00000347193; ENSP00000326544; ENSG00000058404 [Q13554-6]
ENST00000350811; ENSP00000326375; ENSG00000058404 [Q13554-2]
ENST00000353625; ENSP00000326427; ENSG00000058404 [Q13554-4]
ENST00000358707; ENSP00000351542; ENSG00000058404 [Q13554-3]
ENST00000395747; ENSP00000379096; ENSG00000058404 [Q13554-5]
ENST00000395749; ENSP00000379098; ENSG00000058404 [Q13554-1]
ENST00000440254; ENSP00000397937; ENSG00000058404 [Q13554-2]
ENST00000457475; ENSP00000390292; ENSG00000058404 [Q13554-5]
GeneIDi816
KEGGihsa:816
UCSCiuc003tkp.3 human [Q13554-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078803 mRNA Translation: AAD42035.1
AF081572 mRNA Translation: AAD42036.1
AF081924 mRNA Translation: AAD42037.1
AF083419 mRNA Translation: AAD42038.1
AF140350 mRNA Translation: AAD42070.1
U23460 mRNA Translation: AAC99802.1 Frameshift.
AF112472 mRNA Translation: AAD03744.1
AF112471 mRNA Translation: AAD03743.1
AJ252236 mRNA Translation: CAB65120.1
AJ252237 mRNA Translation: CAB65121.1
AJ252238 mRNA Translation: CAB65122.1
AK290148 mRNA Translation: BAF82837.1
AK315663 mRNA Translation: BAG38029.1
CH236960 Genomic DNA Translation: EAL23756.1
CH236960 Genomic DNA Translation: EAL23757.1
CH236960 Genomic DNA Translation: EAL23758.1
CH236960 Genomic DNA Translation: EAL23759.1
CH236960 Genomic DNA Translation: EAL23760.1
CH236960 Genomic DNA Translation: EAL23761.1
CH236960 Genomic DNA Translation: EAL23762.1
BC019070 mRNA Translation: AAH19070.1
U50358 mRNA Translation: AAB16863.1
CCDSiCCDS43573.1 [Q13554-8]
CCDS5483.1 [Q13554-1]
CCDS5484.1 [Q13554-2]
CCDS5485.1 [Q13554-5]
CCDS5486.1 [Q13554-3]
CCDS5487.1 [Q13554-6]
CCDS5488.1 [Q13554-4]
CCDS5489.1 [Q13554-7]
RefSeqiNP_001211.3, NM_001220.4 [Q13554-1]
NP_001280099.1, NM_001293170.1 [Q13554-2]
NP_742075.1, NM_172078.2 [Q13554-2]
NP_742076.1, NM_172079.2 [Q13554-5]
NP_742077.1, NM_172080.2 [Q13554-8]
NP_742078.1, NM_172081.2 [Q13554-3]
NP_742079.1, NM_172082.2 [Q13554-6]
NP_742080.1, NM_172083.2 [Q13554-4]
NP_742081.1, NM_172084.2 [Q13554-7]
UniGeneiHs.351887

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BHHX-ray2.40A/B/C/D11-303[»]
ProteinModelPortaliQ13554
SMRiQ13554
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107266, 52 interactors
DIPiDIP-39770N
IntActiQ13554, 48 interactors
MINTiQ13554
STRINGi9606.ENSP00000379098

Chemistry databases

BindingDBiQ13554
ChEMBLiCHEMBL4121
DrugBankiDB07168 [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
GuidetoPHARMACOLOGYi1556

PTM databases

iPTMnetiQ13554
PhosphoSitePlusiQ13554

Polymorphism and mutation databases

BioMutaiCAMK2B
DMDMi334302890

Proteomic databases

EPDiQ13554
MaxQBiQ13554
PaxDbiQ13554
PeptideAtlasiQ13554
PRIDEiQ13554
ProteomicsDBi59530
59531 [Q13554-2]
59532 [Q13554-3]
59533 [Q13554-4]
59534 [Q13554-5]
59535 [Q13554-6]
59536 [Q13554-7]
59537 [Q13554-8]

Protocols and materials databases

DNASUi816
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258682; ENSP00000258682; ENSG00000058404 [Q13554-8]
ENST00000346990; ENSP00000326518; ENSG00000058404 [Q13554-7]
ENST00000347193; ENSP00000326544; ENSG00000058404 [Q13554-6]
ENST00000350811; ENSP00000326375; ENSG00000058404 [Q13554-2]
ENST00000353625; ENSP00000326427; ENSG00000058404 [Q13554-4]
ENST00000358707; ENSP00000351542; ENSG00000058404 [Q13554-3]
ENST00000395747; ENSP00000379096; ENSG00000058404 [Q13554-5]
ENST00000395749; ENSP00000379098; ENSG00000058404 [Q13554-1]
ENST00000440254; ENSP00000397937; ENSG00000058404 [Q13554-2]
ENST00000457475; ENSP00000390292; ENSG00000058404 [Q13554-5]
GeneIDi816
KEGGihsa:816
UCSCiuc003tkp.3 human [Q13554-1]

Organism-specific databases

CTDi816
DisGeNETi816
EuPathDBiHostDB:ENSG00000058404.19
GeneCardsiCAMK2B
HGNCiHGNC:1461 CAMK2B
HPAiCAB006849
HPA026307
HPA051783
HPA051785
HPA053973
MalaCardsiCAMK2B
MIMi607707 gene
617799 phenotype
neXtProtiNX_Q13554
OpenTargetsiENSG00000058404
PharmGKBiPA91
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0033 Eukaryota
ENOG410XNRX LUCA
GeneTreeiENSGT00760000118944
HOVERGENiHBG108055
InParanoidiQ13554
KOiK04515
OMAiNVHFHGS
OrthoDBiEOG091G0SCS
PhylomeDBiQ13554
TreeFamiTF315229

Enzyme and pathway databases

BRENDAi2.7.11.17 2681
ReactomeiR-HSA-3371571 HSF1-dependent transactivation
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5578775 Ion homeostasis
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-877300 Interferon gamma signaling
R-HSA-936837 Ion transport by P-type ATPases
SignaLinkiQ13554
SIGNORiQ13554

Miscellaneous databases

EvolutionaryTraceiQ13554
GeneWikiiCAMK2B
GenomeRNAii816
PROiPR:Q13554
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000058404 Expressed in 167 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ13554 baseline and differential
GenevisibleiQ13554 HS

Family and domain databases

InterProiView protein in InterPro
IPR013543 Ca/CaM-dep_prot_kinase-assoc
IPR039071 CAMK2
IPR011009 Kinase-like_dom_sf
IPR032710 NTF2-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR43940 PTHR43940, 1 hit
PfamiView protein in Pfam
PF08332 CaMKII_AD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCC2B_HUMAN
AccessioniPrimary (citable) accession number: Q13554
Secondary accession number(s): A4D2K0
, A4D2K1, A4D2K2, A4D2K3, A4D2K4, A4D2K5, A4D2K6, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 31, 2011
Last modified: October 10, 2018
This is version 193 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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