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Entry version 181 (10 Apr 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Eukaryotic translation initiation factor 4E-binding protein 1

Gene

EIF4EBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtein synthesis inhibitor
Biological processTranslation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-166208 mTORC1-mediated signalling
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q13541

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13541

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E-binding protein 1
Short name:
4E-BP1
Short name:
eIF4E-binding protein 1
Alternative name(s):
Phosphorylated heat- and acid-stable protein regulated by insulin 1
Short name:
PHAS-I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187840.4

Human Gene Nomenclature Database

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HGNCi
HGNC:3288 EIF4EBP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602223 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13541

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi37T → A: Abolishes phosphorylation by MTOR and increased ubiquitination by the BCR(KLHL25) complex; when associated with A-46; A-65 and A-70. 1 Publication1
Mutagenesisi46T → A: Abolishes phosphorylation by MTOR and increased ubiquitination by the BCR(KLHL25) complex; when associated with A-37; A-65 and A-70. 1 Publication1
Mutagenesisi57K → R: Impaired ubiquitination by the BCR(KLHL25) complex. 1 Publication1
Mutagenesisi59 – 60LM → AA: Abolishes eIF4E-binding. Increased ubiquitination by the BCR(KLHL25) complex. 1 Publication2
Mutagenesisi65S → A: Abolishes phosphorylation by MTOR and increased ubiquitination by the BCR(KLHL25) complex; when associated with A-37; A-46 and A-70. 1 Publication1
Mutagenesisi69K → R: Does not affect ubiquitination by the BCR(KLHL25) complex. 1 Publication1
Mutagenesisi70T → A: Abolishes phosphorylation by MTOR and increased ubiquitination by the BCR(KLHL25) complex; when associated with A-37; A-46 and A-65. 1 Publication1
Mutagenesisi105K → R: Does not affect ubiquitination by the BCR(KLHL25) complex. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1978

Open Targets

More...
OpenTargetsi
ENSG00000187840

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27715

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3351214

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF4EBP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34921508

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001905132 – 118Eukaryotic translation initiation factor 4E-binding protein 1Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei37Phosphothreonine; by MTORCombined sources3 Publications1
Modified residuei41PhosphothreonineCombined sources1
Modified residuei44PhosphoserineBy similarity1
Modified residuei46Phosphothreonine; by MTORCombined sources3 Publications1
Modified residuei50PhosphothreonineCombined sources1
Modified residuei54PhosphotyrosineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei65Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTORCombined sources4 Publications1
Modified residuei70Phosphothreonine; by MTORCombined sources3 Publications1
Modified residuei77PhosphothreonineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei96PhosphoserineBy similarity1
Modified residuei101Phosphoserine; by DYRK2Combined sources1 Publication1
Modified residuei112PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.5 Publications
Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-37, Thr-46, Ser-65 and Thr-70) or associated with eIF4E.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13541

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13541

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13541

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13541

PeptideAtlas

More...
PeptideAtlasi
Q13541

PRoteomics IDEntifications database

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PRIDEi
Q13541

ProteomicsDB human proteome resource

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ProteomicsDBi
59525

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q13541

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13541

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13541

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q13541

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187840 Expressed in 207 organ(s), highest expression level in body of pancreas

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13541 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005032
CAB005039
HPA023501

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Hypophosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts (via TOS motif) with RPTOR; promoting phosphorylation by mTORC1 (PubMed:12747827).8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108293, 45 interactors

Database of interacting proteins

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DIPi
DIP-30944N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q13541

Protein interaction database and analysis system

More...
IntActi
Q13541, 25 interactors

Molecular INTeraction database

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MINTi
Q13541

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340691

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EJ4X-ray2.25B51-64[»]
1EJHX-ray2.20E/F/G/H54-66[»]
1WKWX-ray2.10B47-66[»]
2JGBX-ray1.70B51-67[»]
2JGCX-ray2.40B51-67[»]
2V8WX-ray2.30B/F51-64[»]
2V8XX-ray2.30B/F51-64[»]
2V8YX-ray2.10B/F51-64[»]
3HXGX-ray2.10C51-67[»]
3HXIX-ray1.80C51-67[»]
3M93X-ray2.90C51-67[»]
3M94X-ray2.05C51-67[»]
3U7XX-ray2.10C/D47-66[»]
4UEDX-ray1.75B50-83[»]
5BXVX-ray2.10B/D43-84[»]
5EKVX-ray3.61B/D51-64[»]
5NVNX-ray1.90B/D50-83[»]
5WBJX-ray3.00T99-118[»]
6BCUelectron microscopy3.43X/Z1-118[»]
6BCXelectron microscopy3.00X/Z1-118[»]

Database of protein disorder

More...
DisProti
DP00028

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13541

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13541

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13541

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi54 – 60YXXXXLphi motifBy similarity7
Motifi114 – 118TOS motif1 Publication5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eIF4E-binding protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J2Z0 Eukaryota
ENOG4112779 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159932

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231190

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050425

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13541

KEGG Orthology (KO)

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KOi
K07205

Identification of Orthologs from Complete Genome Data

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OMAi
PMMTRKI

Database of Orthologous Groups

More...
OrthoDBi
1597535at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13541

TreeFam database of animal gene trees

More...
TreeFami
TF101530

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008606 EIF4EBP
IPR037582 EIF4EBP1

The PANTHER Classification System

More...
PANTHERi
PTHR12669:SF14 PTHR12669:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05456 eIF_4EBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q13541-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGSSCSQT PSRAIPATRR VVLGDGVQLP PGDYSTTPGG TLFSTTPGGT
60 70 80 90 100
RIIYDRKFLM ECRNSPVTKT PPRDLPTIPG VTSPSSDEPP MEASQSHLRN
110
SPEDKRAGGE ESQFEMDI
Length:118
Mass (Da):12,580
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1682A6BA74132966
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L36055 mRNA Translation: AAA62269.1
AB044548 mRNA Translation: BAB18650.1
BT007162 mRNA Translation: AAP35826.1
CR456769 mRNA Translation: CAG33050.1
AK312011 mRNA Translation: BAG34949.1
CH471080 Genomic DNA Translation: EAW63341.1
CH471080 Genomic DNA Translation: EAW63342.1
BC004459 mRNA Translation: AAH04459.1
BC058073 mRNA Translation: AAH58073.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6100.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50866

NCBI Reference Sequences

More...
RefSeqi
NP_004086.1, NM_004095.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.411641

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338825; ENSP00000340691; ENSG00000187840

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1978

UCSC genome browser

More...
UCSCi
uc003xks.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36055 mRNA Translation: AAA62269.1
AB044548 mRNA Translation: BAB18650.1
BT007162 mRNA Translation: AAP35826.1
CR456769 mRNA Translation: CAG33050.1
AK312011 mRNA Translation: BAG34949.1
CH471080 Genomic DNA Translation: EAW63341.1
CH471080 Genomic DNA Translation: EAW63342.1
BC004459 mRNA Translation: AAH04459.1
BC058073 mRNA Translation: AAH58073.1
CCDSiCCDS6100.1
PIRiS50866
RefSeqiNP_004086.1, NM_004095.3
UniGeneiHs.411641

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EJ4X-ray2.25B51-64[»]
1EJHX-ray2.20E/F/G/H54-66[»]
1WKWX-ray2.10B47-66[»]
2JGBX-ray1.70B51-67[»]
2JGCX-ray2.40B51-67[»]
2V8WX-ray2.30B/F51-64[»]
2V8XX-ray2.30B/F51-64[»]
2V8YX-ray2.10B/F51-64[»]
3HXGX-ray2.10C51-67[»]
3HXIX-ray1.80C51-67[»]
3M93X-ray2.90C51-67[»]
3M94X-ray2.05C51-67[»]
3U7XX-ray2.10C/D47-66[»]
4UEDX-ray1.75B50-83[»]
5BXVX-ray2.10B/D43-84[»]
5EKVX-ray3.61B/D51-64[»]
5NVNX-ray1.90B/D50-83[»]
5WBJX-ray3.00T99-118[»]
6BCUelectron microscopy3.43X/Z1-118[»]
6BCXelectron microscopy3.00X/Z1-118[»]
DisProtiDP00028
ProteinModelPortaliQ13541
SMRiQ13541
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108293, 45 interactors
DIPiDIP-30944N
ELMiQ13541
IntActiQ13541, 25 interactors
MINTiQ13541
STRINGi9606.ENSP00000340691

Chemistry databases

ChEMBLiCHEMBL3351214

PTM databases

iPTMnetiQ13541
PhosphoSitePlusiQ13541

Polymorphism and mutation databases

BioMutaiEIF4EBP1
DMDMi34921508

Proteomic databases

EPDiQ13541
jPOSTiQ13541
MaxQBiQ13541
PaxDbiQ13541
PeptideAtlasiQ13541
PRIDEiQ13541
ProteomicsDBi59525
TopDownProteomicsiQ13541

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1978
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338825; ENSP00000340691; ENSG00000187840
GeneIDi1978
KEGGihsa:1978
UCSCiuc003xks.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1978
DisGeNETi1978
EuPathDBiHostDB:ENSG00000187840.4

GeneCards: human genes, protein and diseases

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GeneCardsi
EIF4EBP1
HGNCiHGNC:3288 EIF4EBP1
HPAiCAB005032
CAB005039
HPA023501
MIMi602223 gene
neXtProtiNX_Q13541
OpenTargetsiENSG00000187840
PharmGKBiPA27715

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J2Z0 Eukaryota
ENOG4112779 LUCA
GeneTreeiENSGT00940000159932
HOGENOMiHOG000231190
HOVERGENiHBG050425
InParanoidiQ13541
KOiK07205
OMAiPMMTRKI
OrthoDBi1597535at2759
PhylomeDBiQ13541
TreeFamiTF101530

Enzyme and pathway databases

ReactomeiR-HSA-166208 mTORC1-mediated signalling
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
SignaLinkiQ13541
SIGNORiQ13541

Miscellaneous databases

EvolutionaryTraceiQ13541

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EIF4EBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1978
PMAP-CutDBiQ13541

Protein Ontology

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PROi
PR:Q13541

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187840 Expressed in 207 organ(s), highest expression level in body of pancreas
GenevisibleiQ13541 HS

Family and domain databases

InterProiView protein in InterPro
IPR008606 EIF4EBP
IPR037582 EIF4EBP1
PANTHERiPTHR12669:SF14 PTHR12669:SF14, 1 hit
PfamiView protein in Pfam
PF05456 eIF_4EBP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei4EBP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13541
Secondary accession number(s): B2R502, D3DSW8, Q6IBN3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 23, 2007
Last modified: April 10, 2019
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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